1811-28-5 | Proflavine hemisulfate hydrate

Packsize	Purity	Availability	Price	Discounted Price
1g	>97%(N)	in stock	$31.00	$22.00
5g	>97.0%(N)	in stock	$47.00	$33.00
25g	>97.0%(N)	in stock	$126.00	$88.00
100g	≥ 99% (Assay on anhydrous basis)	in stock	$349.00	$244.00
250g	≥ 99% (Assay on anhydrous basis)	in stock	$644.00	$451.00

Description

• Catalog Number: AA96594
• Chemical Name: Proflavine hemisulfate hydrate
• CAS Number: 1811-28-5
• Molecular Formula: C26H24N6O4S
• Molecular Weight: 516.5716
• MDL Number: MFCD00149650
• SMILES: OS(=O)(=O)O.Nc1ccc2c(c1)nc1c(c2)ccc(c1)N.Nc1ccc2c(c1)nc1c(c2)ccc(c1)N

Computed Properties

• Complexity: 313
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 37
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 6

Literature

• Molecular mechanism of direct proflavine-DNA intercalation: evidence for drug-induced minimum base-stacking penalty pathway.

  The journal of physical chemistry. B 20121011

• Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancer.

  Annals of surgical oncology 20121001

• Intermolecular hydrogen bonds in hetero-complexes of biologically active aromatic molecules probed by the methods of vibrational spectroscopy.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

• Visible light-driven NADH regeneration sensitized by proflavine for biocatalysis.

  Chembiochem : a European journal of chemical biology 20120618

• Vital-dye enhanced fluorescence imaging of GI mucosa: metaplasia, neoplasia, inflammation.

  Gastrointestinal endoscopy 20120401

• A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection.

  Molecular bioSystems 20120301

• Existence of a new emitting singlet state of proflavine: femtosecond dynamics of the excited state processes and quantum chemical studies in different solvents.

  The journal of physical chemistry. A 20120112

• [Studies by means of 1H NMR spectroscopy of complex formation of aromatic biologically active compounds with antibiotic topotecan].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101

• Large-scale symmetry-adapted perturbation theory computations via density fitting and Laplace transformation techniques: investigating the fundamental forces of DNA-intercalator interactions.

  The Journal of chemical physics 20111107

• Fluorimetric study on the interaction between Norfloxacin and Proflavine hemisulphate.

  Journal of fluorescence 20110701

• c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators.

  Chemical communications (Cambridge, England) 20110428

• Proflavine derivatives as fluorescent imaging agents of amyloid deposits.

  Bioorganic & medicinal chemistry letters 20110415

• DNA binding of a proflavine derivative bearing a platinum hanging residue.

  Journal of inorganic biochemistry 20110401

• [Energetics of complex formation of the DNA hairpin structure d(GCGAAGC) with aromatic ligands].

  Biofizika 20110101

• [Comparative sensitivity of liver monoamine oxidases of frog and whitefish to some tricyclic compounds].

  Zhurnal evoliutsionnoi biokhimii i fiziologii 20110101

• Magnetic field effect corroborated with docking study to explore photoinduced electron transfer in drug-protein interaction.

  The journal of physical chemistry. A 20101230

• Synthesis, characterization and cytotoxicity studies of palladium(II)-proflavine complexes.

  Journal of inorganic biochemistry 20101101

• Change of the binding mode of the DNA/proflavine system induced by ethanol.

  The journal of physical chemistry. B 20100701

• The nature of the force-induced conformation transition of dsDNA studied by using single molecule force spectroscopy.

  Langmuir : the ACS journal of surfaces and colloids 20100615

• Triple dye plus rubbing alcohol versus triple dye alone for umbilical cord care.

  Clinical pediatrics 20100101

• 1H and 13C NMR signal assignments of some new N,N'-diacyl proflavine derivatives.

  Magnetic resonance in chemistry : MRC 20090801

• Photo-inducible cytotoxic and clastogenic activities of 3,6-di-substituted acridines obtained by acylation of proflavine.

  European journal of medicinal chemistry 20090601

• Solution structure and thermodynamics of 2',5' RNA intercalation.

  Journal of the American Chemical Society 20090429

• Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures.

  DNA and cell biology 20090401

• [Features of binding of proflavine to DNA at different DNA-ligand concentration ratios].

  Biofizika 20090101

• [Experimental study of proflavine acetate phototransformation processes].

  Gigiena i sanitariia 20090101

• Fluorophore labeling to monitor tRNA dynamics.

  Methods in enzymology 20090101

• Electroanalytical study of proflavine intercalation in 5-methyl or inosine-containing amplicons.

  Analytical and bioanalytical chemistry 20081001

• Role of the third strand in the binding of proflavine and pt-proflavine to poly(rA).2poly(rU): a thermodynamic and kinetic study.

  The journal of physical chemistry. B 20080612

• Cytotoxic activity of proflavine diureas: synthesis, antitumor, evaluation and DNA binding properties of 1',1''-(acridin-3,6-diyl)-3',3''-dialkyldiureas.

  Bioorganic & medicinal chemistry 20080401

• DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• A randomised controlled trial of a double layer of Allevyn compared to Jellonet and proflavin as a tie-over dressing for small skin grafts.

  Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20080101

• Skipjack tuna (Katsuwonus pelamis) liver monoamine oxidase: substrate-inhibitor analysis.

  Doklady. Biochemistry and biophysics 20080101

• Protonation linked equilibria and apparent affinity constants: the thermodynamic profile of the alpha-chymotrypsin-proflavin interaction.

  European biophysics journal : EBJ 20071201

• Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay.

  FEBS letters 20071016

• Quantifying RNA-peptide interaction by single-quantum dot-based nanosensor: an approach for drug screening.

  Analytical chemistry 20071015

• Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine.

  European journal of medicinal chemistry 20071001

• Characterization of the multidrug efflux regulator AcrR from Escherichia coli.

  Biochemical and biophysical research communications 20070914

• On the origin of the decrease in stability of the DNA hairpin d(GCGAAGC) on complexation with aromatic drugs.

  Biophysical chemistry 20070801

• Synthesis, DNA interaction, and cytotoxic activity of a novel proflavine-dithiazolidinone pharmacophore.

  Bioconjugate chemistry 20070101

• A rare cause of breast mass that mimics carcinoma: Foreign body reaction to amorphous surgical material.

  Wiener klinische Wochenschrift 20070101

• Catalytic properties of monoamine oxidase from mink (Mustela vison) liver.

  Doklady. Biochemistry and biophysics 20070101

• [Comparative toxicity of photosensitizers in varying destruction].

  Gigiena i sanitariia 20070101

• Ethidium and proflavine binding to a 2',5'-linked RNA duplex.

  Journal of the American Chemical Society 20061206

• Determination of the DNA-binding characteristics of ethidium bromide, proflavine, and cisplatin by flow injection analysis: usefulness in studies on antitumor drugs.

  Analytical biochemistry 20060815

• Dye-induced aggregation of single stranded RNA: a mechanistic approach.

  Archives of biochemistry and biophysics 20060815

• Physical nature of ethidium and proflavine interactions with nucleic acid bases in the intercalation plane.

  The journal of physical chemistry. B 20060518

• Electrochemical and spectroscopic studies of the interaction of proflavine with DNA.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060301

• Inhibiting protein-amyloid interactions with small molecules: a surface chemistry approach.

  Bioorganic & medicinal chemistry letters 20060215

• Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.

  Research in microbiology 20060101

• Catalytic properties of monoamine oxidase from the lamprey Lampetrafluviatilis liver.

  Doklady. Biochemistry and biophysics 20060101

• Fluorescence of acridinic dyes in anionic surfactant solution.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001

• A randomized study of 3 umbilical cord care regimens at home in thai neonates: comparison of time to umbilical cord separation, parental satisfaction and bacterial colonization.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20050701

• Relaxation kinetics of the interaction between RNA and metal-intercalators: the Poly(A).Poly(U)/platinum-proflavine system.

  Archives of biochemistry and biophysics 20050515

• Dendrimers with both polar and apolar nanocontainer characteristics.

  Journal of the American Chemical Society 20041208

• Changes in newborn bathing practices may increase the risk for omphalitis.

  Clinical pediatrics 20041001

• Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein.

  The EMBO journal 20040804

• Management of ventral hernia after giant exomphalos with external pressure compression using helmet device.

  Journal of pediatric surgery 20040801

• Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding.

  Journal of the American Chemical Society 20040721

• Enzymatic behavior by intercalating molecules in a template-directed ligation reaction.

  Angewandte Chemie (International ed. in English) 20040402

• Equilibria and kinetics of the intercalation of Pt-proflavine and proflavine into calf thymus DNA.

  Archives of biochemistry and biophysics 20031001

• Proflavine acts as a Rev inhibitor by targeting the high-affinity Rev binding site of the Rev responsive element of HIV-1.

  Biochemistry 20030708

• A biochemical logic gate using an enzyme and its inhibitor. Part II: The logic gate.

  Bio Systems 20030601

• To dye or not to dye: a randomized, clinical trial of a triple dye/alcohol regime versus dry cord care.

  Pediatrics 20030101

• Post-surgery vaginal packs.

  Journal of wound care 20021001

• Synthesis and DNA interaction of a mixed proflavine-phenanthroline Tröger base.

  European journal of medicinal chemistry 20020401

• Randomized trial of alcohol versus triple dye for umbilical cord care.

  Clinical pediatrics 20020101

• [NMR study of complex formation of aromatic ligands with heptadeoxynucleotide 5'-d(GCGAAGC) forming stable hairpin structure in aqueous solution].

  Molekuliarnaia biologiia 20020101

• Dialysis cells for controlled DNA: drug binding studies.

  The Analyst 20010601

• Contact dermatitis complicating pinnaplasty.

  British journal of plastic surgery 20010401

• Proflavine-mediated inactivation of Salmonella dublin exposed to visible sunlight in natural fresh water.

  Microbios 20010101

• Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity.

  Biochemistry 19940726

• Kinetics of alpha-chymotrypsin dimerization.

  The Journal of biological chemistry 19760125