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The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells.
Biochimie 20121201
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Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy.
Journal of cancer research and clinical oncology 20120801
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Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities.
Blood 20120315
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Influence of the active compounds of Perilla frutescens leaves on lipid membranes.
Journal of natural products 20120224
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Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles.
International journal of nanomedicine 20120101
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Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium.
Natural product communications 20111201
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Nonmelanoma skin cancer chemoprevention.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20111101
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Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization.
Journal of industrial microbiology & biotechnology 20110901
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Evaluation of the antioxidant and antiproliferative potential of bioflavors.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110701
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An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.
Chembiochem : a European journal of chemical biology 20110614
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Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma.
Journal of cancer research and clinical oncology 20110201
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Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production.
Toxicology 20110111
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Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol.
Journal of proteome research 20110107
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The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor.
Molecular and cellular biochemistry 20101201
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Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol.
Journal of proteomics 20100310
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A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.
Cancer prevention research (Philadelphia, Pa.) 20100201
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The promise of natural products for blocking early events in skin carcinogenesis.
Cancer prevention research (Philadelphia, Pa.) 20100201
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Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin.
Anti-cancer drugs 20100101
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Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol.
Investigational new drugs 20091201
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Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system.
Biotechnology letters 20090901
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Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis.
Chemico-biological interactions 20090515
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Components of lemon essential oil attenuate dementia induced by scopolamine.
Nutritional neuroscience 20090401
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Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma.
Nutrition and cancer 20090101
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High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats.
Journal of pharmaceutical and biomedical analysis 20081201
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Fragrance material review on p-mentha-1,8-dien-7-ol.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081101
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Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol.
Cancer research 20080915
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Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas.
Surgical neurology 20080901
-
Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol.
Archivum immunologiae et therapiae experimentalis 20080801
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Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells.
Bioorganic & medicinal chemistry letters 20080715
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Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis.
Molecular cancer therapeutics 20080701
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A pilot study of perillyl alcohol in pancreatic cancer.
The Journal of surgical research 20080615
-
Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer.
Cancer chemotherapy and pharmacology 20080601
-
Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan.
Rejuvenation research 20080401
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Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer.
Nutrition and cancer 20080101
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Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol.
Journal of experimental therapeutics & oncology 20080101
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Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells.
Cancer letters 20071118
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Modifications of the chemical structure of terpenes in antiplasmodial and antifungal drug research.
Bioorganic & medicinal chemistry letters 20071115
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Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.
Archives of biochemistry and biophysics 20070901
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Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.
The Journal of pharmacology and experimental therapeutics 20070301
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Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review.
Surgical neurology 20061201
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Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells.
Toxicology and applied pharmacology 20060601
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Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells.
Cancer letters 20060518
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol.
Surgical neurology 20060101
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Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.
Oncology 20060101
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Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis.
Nutrition and cancer 20060101
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In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression.
Chemotherapy 20060101
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Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549.
Journal of experimental therapeutics & oncology 20060101
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Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway.
Cancer research 20050915
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Effect of D-limonene on immune response in BALB/c mice with lymphoma.
International immunopharmacology 20050501
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Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells.
Oncology reports 20050501
-
CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells.
Plant molecular biology 20050401
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An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation.
Journal of pharmaceutical and biomedical analysis 20050309
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Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo.
Journal of biomedical science 20050101
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A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 20041115
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Perillyl alcohol is an angiogenesis inhibitor.
The Journal of pharmacology and experimental therapeutics 20041101
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A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days.
Cancer chemotherapy and pharmacology 20041001
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Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo.
Breast cancer research and treatment 20040401
-
Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects.
Toxicology and applied pharmacology 20040301
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Development of a perillyl alcohol topical cream formulation.
International journal of pharmaceutics 20040128
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Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101
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Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro.
Anticancer research 20040101
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Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries.
European journal of pharmacology 20031114
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Phase I trial of perillyl alcohol administered four times daily continuously.
Cancer chemotherapy and pharmacology 20031101
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Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia.
International journal of radiation oncology, biology, physics 20031101
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Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro.
Life sciences 20031017
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Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells.
European journal of cancer (Oxford, England : 1990) 20031001
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Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
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Perillyl alcohol as a radio-/chemosensitizer in malignant glioma.
The Journal of biological chemistry 20030919
-
Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells.
The Prostate 20030915
-
Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer.
Investigational new drugs 20030801
-
Monoterpene regulation of Ras and Ras-related protein expression.
Journal of lipid research 20030601
-
A phase I trial of perillyl alcohol in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology 20030601
-
Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis.
Cancer research 20030515
-
Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model.
International journal of molecular medicine 20021201
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Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression.
Cancer letters 20020726
-
Effects of perillyl alcohol on melanoma in the TPras mouse model.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020601
-
A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group Study E2E96.
Gynecologic oncology 20020601
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Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 20020501
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Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest.
Leukemia 20020201
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Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol.
Carcinogenesis 20020101
-
Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome p450 enzymes in rat liver microsomes.
Chemical research in toxicology 20020101
-
Phase I study of perillyl alcohol in patients with refractory malignancies.
Cancer biology & therapy 20020101
-
Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention.
Anticancer research 20020101
-
Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer.
International journal of gastrointestinal cancer 20020101
