1892-57-5 | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$47.00	$33.00
25g	95%	in stock	$108.00	$76.00

Description

• Catalog Number: AB50388
• Chemical Name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
• CAS Number: 1892-57-5
• Molecular Formula: C8H17N3
• Molecular Weight: 155.2407
• MDL Number: MFCD00044916
• SMILES: CCN=C=NCCCN(C)C

Computed Properties

• Complexity: 134
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 1.9

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• Covalent immobilization of proteins on carbon nanotubes using the cross-linker 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide--a critical assessment.

  Bioconjugate chemistry 20081001

• ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.

  Proceedings of the National Academy of Sciences of the United States of America 20080923

• TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.

  The Journal of biological chemistry 20080919

• Immobilization of NaIO4-treated heparin on PEG-modified 316L SS surface for high anti-thrombin-III binding.

  Journal of biomedical materials research. Part A 20080901

• Tissue-engineered recombinant human collagen-based corneal substitutes for implantation: performance of type I versus type III collagen.

  Investigative ophthalmology & visual science 20080901

• Synthesis and antibacterial activity of a new series of 2,3,5,7-substituted-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives.

  Chemical & pharmaceutical bulletin 20080901

• Surface chemical functionalization of cylindrical nanopores derived from a polystyrene-poly(methylmethacrylate) diblock copolymer via amidation.

  Langmuir : the ACS journal of surfaces and colloids 20080819

• Topographical and functional characterization of the ssDNA probe layer generated through EDC-mediated covalent attachment to nanocrystalline diamond using fluorescence microscopy.

  Langmuir : the ACS journal of surfaces and colloids 20080819

• Radioprotection of tendon tissue via crosslinking and free radical scavenging.

  Clinical orthopaedics and related research 20080801

• Immobilization of cytochrome c on cysteamine-modified gold electrodes with EDC as coupling agent.

  Talanta 20080715

• Development of an automated digestion and droplet deposition microfluidic chip for MALDI-TOF MS.

  Journal of the American Society for Mass Spectrometry 20080701

• Synthesis and anti-melanogenic effects of lipoic acid-polyethylene glycol ester.

  The Journal of pharmacy and pharmacology 20080701

• Plasma-assisted immobilization of heparin onto low-density polyethylene surface.

  Chemical & pharmaceutical bulletin 20080701

• Investigation on clotting and hemolysis characteristics of heparin-immobilized polyether sulfones biomembrane.

  Journal of biomedical materials research. Part A 20080601

• Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement.

  International journal of nanomedicine 20080601

• Key labeling technologies to tackle sizeable problems in RNA structural biology.

  International journal of molecular sciences 20080601

• NHS-mediated QDs-peptide/protein conjugation and its application for cell labeling.

  Talanta 20080530

• Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products.

  Journal of immunological methods 20080520

• A polysaccharide of Alloiococcus otitidis, a new pathogen of otitis media: chemical structure and synthesis of a neoglycoconjugate thereof.

  Carbohydrate research 20080505

• Biomechanical properties of carbodiimide crosslinked collagen: influence of the formation of ester crosslinks.

  Journal of biomedical materials research. Part A 20080501

• Nanoaggregate of thermosensitive chitosan-Pluronic for sustained release of hydrophobic drug.

  Colloids and surfaces. B, Biointerfaces 20080501

• Vascular endothelial growth factor immobilized in collagen scaffold promotes penetration and proliferation of endothelial cells.

  Acta biomaterialia 20080501

• [Synthesis and identification of penicillic-acid antigens from Penicillium cyclopium].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20080501

• Analysis of flurbiprofen, ketoprofen and etodolac enantiomers by pre-column derivatization RP-HPLC and application to drug-protein binding in human plasma.

  Journal of pharmaceutical and biomedical analysis 20080414

• Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.

  The Journal of biological chemistry 20080404

• Spectrophotometric determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow injection analysis.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080401

• Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule.

  Journal of molecular biology 20080321

• Evaluation of the release rate of bioactive recombinant human epidermal growth factor from crosslinking collagen sponges.

  Journal of materials science. Materials in medicine 20080301

• Discovery and characterization of a putrescine oxidase from Rhodococcus erythropolis NCIMB 11540.

  Applied microbiology and biotechnology 20080301

• Simultaneous processing of fibril formation and cross-linking improves mechanical properties of collagen.

  Biomacromolecules 20080301

• Analysis of primary aromatic amines using precolumn derivatization by HPLC fluorescence detection and online MS identification.

  Journal of separation science 20080301

• [Fabrication of a novel cartilage acellular matrix scaffold for cartilage tissue engineering].

  Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20080301

• Attachment of functionalized single-walled carbon nanotubes (SWNTs) to silicon surfaces.

  Journal of nanoscience and nanotechnology 20080301

• Nano-vectors for efficient liver specific gene transfer.

  International journal of nanomedicine 20080301

• Proximity-activated nanoparticles: in vitro performance of specific structural modification by enzymatic cleavage.

  International journal of nanomedicine 20080301

• Modifying the surface charge of single track-etched conical nanopores in polyimide.

  Nanotechnology 20080227

• Molecular model of an alpha-helical prion protein dimer and its monomeric subunits as derived from chemical cross-linking and molecular modeling calculations.

  Journal of molecular biology 20080215

• In situ electrodeposited nanoparticles for facilitating electron transfer across self-assembled monolayers in biosensor design.

  Talanta 20080215

• Ionic interaction of myosin loop 2 with residues located beyond the N-terminal part of actin probed by chemical cross-linking.

  Biochimica et biophysica acta 20080201

• EDC/NHS-crosslinked type II collagen-chondroitin sulfate scaffold: characterization and in vitro evaluation.

  Journal of materials science. Materials in medicine 20080201

• Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg372.

  British journal of haematology 20080201

• Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer.

  Biomacromolecules 20080201

• Folate-conjugated polymer micelles for active targeting to cancer cells: preparation, in vitro evaluation of targeting ability and cytotoxicity.

  Nanotechnology 20080130

• A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.

  The Journal of biological chemistry 20080118

• Synthesis and redox behavior of flavin mononucleotide-functionalized single-walled carbon nanotubes.

  Journal of the American Chemical Society 20080116

• Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ.

  The EMBO journal 20080109

• Effect of hyaluronic acid molecular weight on the morphology of quantum dot-hyaluronic acid conjugates.

  International journal of biological macromolecules 20080101

• Monitoring single-molecule reactivity on a carbon nanotube.

  Nano letters 20080101

• Carbodiimide cross-linked hyaluronic acid hydrogels as cell sheet delivery vehicles: characterization and interaction with corneal endothelial cells.

  Journal of biomaterials science. Polymer edition 20080101

• Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water.

  Bioinorganic chemistry and applications 20080101

• Killing cancer cells by targeted drug-carrying phage nanomedicines.

  BMC biotechnology 20080101

• A high sensitivity assay for the inflammatory marker C-Reactive protein employing acoustic biosensing.

  Journal of nanobiotechnology 20080101

• Synthesis and bio-imaging application of highly luminescent mercaptosuccinic acid-coated CdTe nanocrystals.

  PloS one 20080101

• Improved northern blot method for enhanced detection of small RNA.

  Nature protocols 20080101

• Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis.

  Arthritis research & therapy 20080101

• YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules.

  BMC biochemistry 20080101

• Label-free detection of biomolecular interactions in real time with a nano-porous silicon-based detection method.

  Proteome science 20080101

• [Conjugation of chondroitin sulfates with amines].

  Bioorganicheskaia khimiia 20080101

• Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.

  BMC developmental biology 20080101

• Intra-molecular cross-linking of acidic residues for protein structure studies.

  European journal of mass spectrometry (Chichester, England) 20080101

• Measurement of interaction forces between fibrinogen coated probes and mica surface with the atomic force microscope: The pH and ionic strength effect.

  Biointerphases 20080101

• The effect of cross-linking time on a porous freeze-dried collagen scaffold using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide as a cross-linker.

  Journal of applied biomaterials & biomechanics : JABB 20080101

• Bioconjugate recognition molecules to quantum dots as tumor probes.

  Journal of biomedical materials research. Part A 20071215

• Accelerated direct electrochemistry of hemoglobin based on hemoglobin-carbon nanotube (Hb-CNT) assembly.

  Journal of colloid and interface science 20071215

• Proteins combination on PHBV microsphere scaffold to regulate Hep3B cells activity and functionality: a model of liver tissue engineering system.

  Journal of biomedical materials research. Part A 20071201

• Ferrocenylnaphthalene diimide-based electrochemical ribonuclease assay.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20071201

• Biomimetic and bioactive nanofibrous scaffolds from electrospun composite nanofibers.

  International journal of nanomedicine 20071201

• PEGylation of nanoparticles improves their cytoplasmic transport.

  International journal of nanomedicine 20071201

• Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts.

  Biomedical materials (Bristol, England) 20071201

• Gelatin microspheres cross-linked with EDC as a drug delivery system for doxycyline: development and characterization.

  Journal of microencapsulation 20071101

• Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.

  Nature chemical biology 20071101

• Analysis of dideoxyadenosine triphosphate by CE with fluorescence detection. I. Derivatization through the phosphate group.

  Electrophoresis 20071101

• 6-oxy-(acetyl piperazine) fluorescein as a new fluorescent labeling reagent for free fatty acids in serum using high-performance liquid chromatography.

  Journal of chromatography. A 20071026

• Magnetic Fe2O3-polystyrene/PPy core/shell particles: bioreactivity and self-assembly.

  Langmuir : the ACS journal of surfaces and colloids 20071023

• Cross-linkage of hydroxyapatite/gelatin nanocomposite using imide-based zero-length cross-linker.

  Journal of materials science. Materials in medicine 20071001

• Rapid liposomal agglutination card test for the detection of antigens in patients with active tuberculosis.

  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20071001

• The interplay of processivity, substrate inhibition and a secondary substrate binding site of an insect exo-beta-1,3-glucanase.

  Biochimica et biophysica acta 20070901

• Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats.

  International journal of nanomedicine 20070901

• Enantioselective separation of racemic juvenile hormone III by normal-phase high-performance liquid chromatography and preparation of [(2)H(3)]juvenile hormone III as an internal standard for liquid chromatography-mass spectrometry quantification.

  Journal of chromatography. A 20070817

• Evaluation and biological characterization of bilayer gelatin/chondroitin-6-sulphate/hyaluronic acid membrane.

  Journal of biomedical materials research. Part B, Applied biomaterials 20070801

• In vitro growth and differentiated activities of human periodontal ligament fibroblasts cultured on salmon collagen gel.

  Journal of biomedical materials research. Part A 20070801

• Determination of highly soluble L-carnitine in biological samples by reverse phase high performance liquid chromatography with fluorescent derivatization.

  Archives of pharmacal research 20070801

• Quantitative analysis of EDC-condensed DNA on vertically aligned carbon nanofiber gene delivery arrays.

  Biotechnology and bioengineering 20070701

• Covalent immobilization of redox enzyme on electrospun nonwoven poly(acrylonitrile-co-acrylic acid) nanofiber mesh filled with carbon nanotubes: a comprehensive study.

  Biotechnology and bioengineering 20070701

• Novel elastic material from collagen for tissue engineering.

  Journal of materials science. Materials in medicine 20070701

• Physical and biological properties of collagen-phospholipid polymer hybrid gels.

  Biomaterials 20070701

• Cross-linking electrospun type II collagen tissue engineering scaffolds with carbodiimide in ethanol.

  Tissue engineering 20070701

• Transferrin-conjugated solid lipid nanoparticles for enhanced delivery of quinine dihydrochloride to the brain.

  The Journal of pharmacy and pharmacology 20070701

• Immobilization of simulated reducing agent at the surface of SiO2 fillers in dental composite resins.

  Dental materials journal 20070701

• Thermal denaturation and aggregation properties of Atlantic salmon myofibrils and myosin from white and red muscles.

  Journal of agricultural and food chemistry 20070613

• Amperometric determination of hydrogen peroxide by functionalized carbon nanotubes through EDC/NHS coupling chemistry.

  Journal of nanoscience and nanotechnology 20070601

• RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DO3A) conjugate for detecting angiogenesis biomarker alpha(v) beta3 integrin with MRT, mapping.

  International journal of nanomedicine 20070601

• Measurement of triclosan in water using a magnetic particle enzyme immunoassay.

  Journal of agricultural and food chemistry 20070516

• Conjugation of enzyme on superparamagnetic nanogels covered with carboxyl groups.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

• EDC/NHS-mediated heparinization of small intestinal submucosa for recombinant adeno-associated virus serotype 2 binding and transduction.

  Biomaterials 20070501

• Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide.

  Magnetic resonance in chemistry : MRC 20070501

• Enhanced resistance of polyelectrolyte multilayer microcapsules to pepsin erosion and release properties of encapsulated indomethacin.

  Biomacromolecules 20070501

• The importance of human FcgammaRI in mediating protection to malaria.

  PLoS pathogens 20070501

• Molecular basis of guanine nucleotide dissociation inhibitor activity of human neuroglobin by chemical cross-linking and mass spectrometry.

  Journal of molecular biology 20070420

• Cholesterol biosensor based on N-(2-aminoethyl)-3-aminopropyl-trimethoxysilane self-assembled monolayer.

  Analytical biochemistry 20070415

• In vivo evaluation of a biodegradable EDC/NHS-cross-linked gelatin peripheral nerve guide conduit material.

  Macromolecular bioscience 20070410

• Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events.

  Analytical biochemistry 20070401

• Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.

  PLoS medicine 20070401

• Aqueous in situ derivatization of carboxylic acids by an ionic carbodiimide and 2,2,2-trifluoroethylamine for electron-capture detection.

  Journal of chromatography. A 20070323

• Application of thiolated gold nanoparticles for the enhancement of glucose oxidase activity.

  Langmuir : the ACS journal of surfaces and colloids 20070313

• Comparison of the effects of acylation and amidation on the antimicrobial and antiviral properties of lactoferrin.

  Letters in applied microbiology 20070301

• Neurite outgrowths of neurons with neurotrophin-coated carbon nanotubes.

  Journal of bioscience and bioengineering 20070301

• Synthesis and characterization of nanoscale dendritic RGD clusters for potential applications in tissue engineering and drug delivery.

  International journal of nanomedicine 20070301

• Stabilization of alpha-chymotrypsin by covalent immobilization on amine-functionalized superparamagnetic nanogel.

  Journal of biotechnology 20070220

• Wound closure with EDC cross-linked cultured skin substitutes grafted to athymic mice.

  Biomaterials 20070201

• Functionalization of single-walled carbon nanotube by the covalent modification with polymer chains.

  Journal of colloid and interface science 20070201

• Chemical modification results in hyperactivation and thermostabilization of Fusarium solani glucoamylase.

  Canadian journal of microbiology 20070201

• Mechanism of formation of actomyosin interface.

  Journal of molecular biology 20070119

• Studies of novel hyaluronic acid-collagen sponge materials composed of two different species of type I collagen.

  Journal of biomaterials applications 20070101

• Effect of aniline coupling on kinetic and thermodynamic properties of Fusarium solani glucoamylase.

  Applied microbiology and biotechnology 20070101

• Synthesis and characterization of pH-sensitive thiol-containing chitosan beads for controlled drug delivery applications.

  Drug delivery 20070101

• Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine.

  Rapid communications in mass spectrometry : RCM 20070101

• A conventional new procedure for N-acylation of unprotected amino acids.

  Chemical & pharmaceutical bulletin 20070101

• Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells.

  Journal of nanobiotechnology 20070101

• Synthesis of Poly[APMA]-DOTA-64Cu conjugates for interventional radionuclide therapy of prostate cancer: assessment of intratumoral retention by micro-positron emission tomography.

  Molecular imaging 20070101

• Turnip yellow mosaic virus as a chemoaddressable bionanoparticle.

  Bioconjugate chemistry 20070101

• Enhancing the strength of the tendon-suture interface using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and cyanoacrylate.

  The Journal of hand surgery 20070101

• Structure of the dimeric N-glycosylated form of fungal beta-N-acetylhexosaminidase revealed by computer modeling, vibrational spectroscopy, and biochemical studies.

  BMC structural biology 20070101

• The effect of carbodiimide-derivatized hyaluronic acid and gelatin surface modification on peroneus longus tendon graft in a short-term canine model in vivo.

  The Journal of hand surgery 20070101

• One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX.

  BMC biotechnology 20070101

• Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant.

  PloS one 20070101

• Nanopore-based kinetics analysis of individual antibody-channel and antibody-antigen interactions.

  BMC bioinformatics 20070101

• The alpha-hemolysin nanopore transduction detector - single-molecule binding studies and immunological screening of antibodies and aptamers.

  BMC bioinformatics 20070101

• Role of reaction kinetics and mass transport in glucose sensing with nanopillar array electrodes.

  Journal of biological engineering 20070101

• Fluorescence intensity and intermittency as tools for following dopamine bioconjugate processing in living cells.

  Journal of biomedicine & biotechnology 20070101

• Imaging GABAc receptors with ligand-conjugated quantum dots.

  Journal of biomedicine & biotechnology 20070101

• Bio-nanopatterning of Surfaces.

  Nanoscale research letters 20070101

• Characterisation of membrane mimetics on a dual polarisation interferometer.

  Biosensors & bioelectronics 20061215

• Influence of modified extracellular matrices on TI6AL4V implants on binding and release of VEGF.

  Journal of biomedical materials research. Part A 20061215

• Effect of curing time and concentration for a chemical treatment that improves surface gliding for extrasynovial tendon grafts in vitro.

  Journal of biomedical materials research. Part A 20061201

• EDC cross-linking improves skin substitute strength and stability.

  Biomaterials 20061201

• A novel hydrogel crosslinked hyaluronan with glycol chitosan.

  Journal of materials science. Materials in medicine 20061201

• Enhanced dermal regeneration using modified collagen scaffolds: experimental porcine study.

  The International journal of artificial organs 20061201

• Optimization of the conjugation method for a serogroup B/C meningococcal vaccine.

  Biotechnology and applied biochemistry 20061101

• Antibody-conjugated soybean oil-filled calcium phosphate nanoshells for targetted delivery of hydrophobic molecules.

  Journal of microencapsulation 20061101

• Synthesis and characterization of Pseudomonas aeruginosa alginate-tetanus toxoid conjugate.

  Journal of medical microbiology 20061001

• Surface treatment of flexor tendon autografts with carbodiimide-derivatized hyaluronic Acid. An in vivo canine model.

  The Journal of bone and joint surgery. American volume 20061001

• Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions.

  Biomaterials 20060901

• Directed type IV collagen self-assembly on hydroxylated PTFE.

  Journal of biomedical materials research. Part A 20060901

• Chondroitin sulfate-based anti-inflammatory macromolecular prodrugs.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060901

• Bioassay labels based on apoferritin nanovehicles.

  Chembiochem : a European journal of chemical biology 20060901

• Surface plasmon resonance immunosensor for histamine based on an indirect competitive immunoreaction.

  Analytica chimica acta 20060818

• EDC-mediated DNA attachment to nanocrystalline CVD diamond films.

  Biosensors & bioelectronics 20060815

• Molecular contacts for chlorosome envelope proteins revealed by cross-linking studies with chlorosomes from Chlorobium tepidum.

  Biochemistry 20060801

• Identification of catalytic amino acids of cyclodextran glucanotransferase from Bacillus circulans T-3040.

  Bioscience, biotechnology, and biochemistry 20060801

• Identification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis.

  The Journal of biological chemistry 20060721

• Optimization of surface modifications of extrasynovial tendon to improve its gliding ability in a canine model in vitro.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060701

• Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel.

  Colloids and surfaces. B, Biointerfaces 20060701

• Quantum dot-mediated detection of gamma-aminobutyric acid binding sites on the surface of living pollen protoplasts in tobacco.

  Chemistry & biology 20060701

• A novel chitosan oligosaccharide-stearic acid micelles for gene delivery: properties and in vitro transfection studies.

  International journal of pharmaceutics 20060606

• Development of immunoassays for the detection of kanamycin in veterinary fields.

  Journal of veterinary science 20060601

• TGF-beta1 immobilized tri-co-polymer for articular cartilage tissue engineering.

  Journal of biomedical materials research. Part B, Applied biomaterials 20060501

• Influence of paraformaldehyde and EDAC fixation on the demonstrability of hormones (histamine, endorphin, triiodothyronine) in rat immune cells: an immunocytochemical comparative analysis.

  Cell biology international 20060501

• A simple, cross-linked collagen tissue substitute for corneal implantation.

  Investigative ophthalmology & visual science 20060501

• Identification of the binding region of the [2Fe-2S] ferredoxin in stearoyl-acyl carrier protein desaturase: insight into the catalytic complex and mechanism of action.

  Biochemistry 20060418

• Grafting of poly(ethylene glycol) onto poly(acrylic acid)-coated glass for a protein-resistant surface.

  Analytical chemistry 20060415

• Physical characterization of vascular grafts cultured in a bioreactor.

  Biomaterials 20060401

• Structural and functional analysis of the coupling subunit F in solution and topological arrangement of the stalk domains of the methanogenic A1AO ATP synthase.

  Journal of bioenergetics and biomembranes 20060401

• Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel.

  Journal of controlled release : official journal of the Controlled Release Society 20060310

• Long-term and zero-order release of basic fibroblast growth factor from heparin-conjugated poly(L-lactide-co-glycolide) nanospheres and fibrin gel.

  Biomaterials 20060301

• A carboxylic residue at the high-affinity, Mn-binding site participates in the binding of iron cations that block the site.

  Biochimica et biophysica acta 20060301

• Novel self-aggregates of chitosan oligosaccharide grafted stearic acid: preparation, characterization and protein association.

  Die Pharmazie 20060301

• Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents.

  International journal of nanomedicine 20060301

• Electrospinning of collagen and elastin for tissue engineering applications.

  Biomaterials 20060201

• Effect of nucleotide on interaction of the 567-578 segment of myosin heavy chain with actin.

  Biochimica et biophysica acta 20060201

• Rotations of a few cross-bridges in muscle by confocal total internal reflection microscopy.

  Biochimica et biophysica acta 20060201

• Immobilization of horseradish peroxidase on multi-wall carbon nanotubes and its electrochemical properties.

  Biotechnology letters 20060101

• Cytotoxic activity of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide is underlain by DNA interchain cross-linking.

  Cellular and molecular life sciences : CMLS 20060101

• Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein.

  BMC cancer 20060101

• [Structure and functional properties of temperature-sensitive derivatives of immobilized proteins].

  Prikladnaia biokhimiia i mikrobiologiia 20060101

• [Conjugation and immunogenic evaluation of complete immunogen for the small molecular environmental pollutants 2,4-D].

  Huan jing ke xue= Huanjing kexue 20060101

• A method for high-throughput gene expression signature analysis.

  Genome biology 20060101

• A nanoparticle-based immobilization assay for prion-kinetics study.

  Journal of nanobiotechnology 20060101

• Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline.

  Respiratory research 20060101

• [Chemical modification of heparin].

  Bioorganicheskaia khimiia 20060101

• Quantum dot optical encoded polystyrene beads for DNA detection.

  Journal of biomedical optics 20060101

• Carbodiimide-based benzimidazole library method.

  Journal of combinatorial chemistry 20060101

• Optimization of the modification of carrier proteins with aminated haptens.

  Journal of immunological methods 20051220

• Development of an HPLC-fluorescence determination method for carboxylic acids related to the tricarboxylic acid cycle as a metabolome tool.

  Biomedical chromatography : BMC 20051201

• Crosslinking of collagen with dendrimers.

  Journal of biomedical materials research. Part A 20051201

• Differential light chain assembly influences outer arm dynein motor function.

  Molecular biology of the cell 20051201

• Effects of modified collagen matrices on human umbilical vein endothelial cells.

  The International journal of artificial organs 20051201

• [Determination of 2,4-D using disposable amperometric immunosensor].

  Huan jing ke xue= Huanjing kexue 20051101

• Hydroxypropyl chitosan bearing beta-cyclodextrin cavities: synthesis and slow release of its inclusion complex with a model hydrophobic drug.

  Macromolecular bioscience 20051020

• Synthesis of poly(Pro-Hyp-Gly)(n) by direct poly-condensation of (Pro-Hyp-Gly)(n), where n=1, 5, and 10, and stability of the triple-helical structure.

  Biopolymers 20051015

• Towards a label-free optical porous silicon DNA sensor.

  Biosensors & bioelectronics 20051015

• Development of tumor targeting bioprobes ((111)In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

• Development and potential of a biomimetic chitosan/type II collagen scaffold for cartilage tissue engineering.

  Chinese medical journal 20050905

• Direct interaction between prion protein and tubulin.

  Biochemical and biophysical research communications 20050826

• Preparation of porcine small intestinal submucosa sponge and their application as a wound dressing in full-thickness skin defect of rat.

  International journal of biological macromolecules 20050701

• Changes in mechanical properties and cellularity during long-term culture of collagen fiber ACL reconstruction scaffolds.

  Journal of biomedical materials research. Part A 20050615

• A new anti-adhesion film synthesized from polygalacturonic acid with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide crosslinker.

  Biomaterials 20050601

• Electrochemical detection of enzyme labeled DNA based on disposable pencil graphite electrode.

  Journal of pharmaceutical and biomedical analysis 20050601

• Covalent cross-links between the gamma subunit (FXYD2) and alpha and beta subunits of Na,K-ATPase: modeling the alpha-gamma interaction.

  The Journal of biological chemistry 20050506

• [The epitope analysis of beta Netrin and preparation and characterization of its antibodies].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20050501

• Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil.

  Journal of drug targeting 20050501

• Determination of psilocybin in hallucinogenic mushrooms by reversed-phase liquid chromatography with fluorescence detection.

  Talanta 20050430

• The N. gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism.

  PLoS biology 20050401

• Synthesis, characterization of dihydrolipoic acid capped gold nanoparticles, and functionalization by the electroluminescent luminol.

  Langmuir : the ACS journal of surfaces and colloids 20050315

• Improved stabilization of chemically aminated enzymes via multipoint covalent attachment on glyoxyl supports.

  Journal of biotechnology 20050302

• Carbodiimide treatment dramatically potentiates the anticalcific effect of alpha-amino oleic acid on glutaraldehyde-fixed aortic wall tissue.

  The Annals of thoracic surgery 20050301

• Chemical cross-linking and high-performance Fourier transform ion cyclotron resonance mass spectrometry for protein interaction analysis: application to a calmodulin/target peptide complex.

  Analytical chemistry 20050115

• Synthesis of fluorescent label, DBD-beta-proline, and the resolution efficiency for chiral amines by reversed-phase chromatography.

  Biomedical chromatography : BMC 20050101

• 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide interference with Lowry method.

  Analytical biochemistry 20050101

• Conjugation of DOTA using isolated phenolic active esters: the labeling and biodistribution of albumin as blood pool marker.

  Bioconjugate chemistry 20050101

• [Modification of hyaluronic acid with aromatic amino acids].

  Bioorganicheskaia khimiia 20050101

• Characteristics of chemically cross-linked myosin gels.

  Journal of biomaterials science. Polymer edition 20050101

• Build-up of collagen and hyaluronic acid polyelectrolyte multilayers.

  Biomacromolecules 20050101

• Proteomic profiling of erythrocyte proteins by proteolytic digestion chip and identification using two-dimensional electrospray ionization tandem mass spectrometry.

  Journal of proteome research 20050101

• Modification of porcine pancreatic lipase with Z-proline.

  Preparative biochemistry & biotechnology 20050101

• Antigen-decorated shell cross-linked nanoparticles: synthesis, characterization, and antibody interactions.

  Bioconjugate chemistry 20050101

• Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection.

  Respiratory research 20050101

• Mapping protein interfaces by chemical cross-linking and Fourier transform ion cyclotron resonance mass spectrometry: application to a calmodulin / adenylyl cyclase 8 peptide complex.

  European journal of mass spectrometry (Chichester, England) 20050101

• Quantification of residual EDU (N-ethyl-N'-(dimethylaminopropyl) carbodiimide (EDC) hydrolyzed urea derivative) and other residual by LC-MS/MS.

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• Formation, characterization, and chemistry of undecanoic acid-terminated silicon surfaces: patterning and immobilization of DNA.

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  European journal of biochemistry 20041101

• A chitosan-arginine conjugate as a novel anticoagulation biomaterial.

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• Proteomic profiling of platelet proteins by trypsin immobilized self-assembled monolayers digestion chip and protein identification using electrospray ionization tandem mass spectrometry.

  Journal of biomedical materials research. Part A 20041001

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  Langmuir : the ACS journal of surfaces and colloids 20040928

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  The Journal of biological chemistry 20040917

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  International journal of pharmaceutics 20040708

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  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20040601

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  Yao xue xue bao = Acta pharmaceutica Sinica 20040601

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  The Journal of biological chemistry 20040521

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  Langmuir : the ACS journal of surfaces and colloids 20040511

• Cross-linking phosphatidylinositol-specific phospholipase C traps two activating phosphatidylcholine molecules on the enzyme.

  The Journal of biological chemistry 20040507

• Mapping the topology and determination of a low-resolution three-dimensional structure of the calmodulin-melittin complex by chemical cross-linking and high-resolution FTICRMS: direct demonstration of multiple binding modes.

  Biochemistry 20040427

• Enzyme-linked immunosorbent assay development for the beta-adrenergic agonist zilpaterol.

  Journal of agricultural and food chemistry 20040421

• Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain.

  The Journal of biological chemistry 20040416

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  Langmuir : the ACS journal of surfaces and colloids 20040413

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  Journal of biomedical materials research. Part A 20040401

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  PLoS biology 20040401

• Subunit proximity in the H+-translocating NADH-quinone oxidoreductase probed by zero-length cross-linking.

  Biochemistry 20040330

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  Journal of chromatography. A 20040326

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  Journal of colloid and interface science 20040315

• Electrochemical control of protein monolayers at indium tin oxide surfaces for the reagentless optical biosensing of nitric oxide.

  Langmuir : the ACS journal of surfaces and colloids 20040302

• Development of a direct-binding chloramphenicol sensor based on thiol or sulfide mediated self-assembled antibody monolayers.

  Biosensors & bioelectronics 20040215

• Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development.

  Journal of microbiological methods 20040201

• Purification and characterization of ascorbic acid 2-kinase from Flavobacterium devorans ATCC 10829.

  Biochimie 20040201

• Improvement of stability and cell adhesion properties of polyelectrolyte multilayer films by chemical cross-linking.

  Biomacromolecules 20040101

• Biocompatibility and biodegradation of cross-linked gelatin/hyaluronic acid sponge in rat subcutaneous tissue.

  Journal of biomaterials science. Polymer edition 20040101

• Solid-supported solution-phase synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones.

  Journal of combinatorial chemistry 20040101

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  Journal of biomaterials science. Polymer edition 20040101

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  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101

• Electron beam-induced graft polymerization of acrylic acid and immobilization of arginine-glycine-aspartic acid-containing peptide onto nanopatterned polycaprolactone.

  Biomacromolecules 20040101

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  Acta veterinaria Scandinavica 20040101

• Modulation of angiogenic potential of collagen matrices by covalent incorporation of heparin and loading with vascular endothelial growth factor.

  Tissue engineering 20040101

• Application of cross-linked salmon atelocollagen to the scaffold of human periodontal ligament cells.

  Journal of bioscience and bioengineering 20040101

• Novel biomaterial from reinforced salmon collagen gel prepared by fibril formation and cross-linking.

  Journal of bioscience and bioengineering 20040101

• Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry.

  Biochemistry 20031216

• Endosomal proteolysis of glucagon at neutral pH generates the bioactive degradation product miniglucagon-(19-29).

  Endocrinology 20031201

• The study of the sterilization effect of gamma ray irradiation of immobilized collagen polypropylene nonwoven fabric surfaces.

  Journal of biomedical materials research. Part A 20031201

• Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein.

  Chemical & pharmaceutical bulletin 20031201

• Glycosynthase activity of Bacillus licheniformis 1,3-1,4-beta-glucanase mutants: specificity, kinetics, and mechanism.

  Biochemistry 20031118

• Electrogenerated chemiluminescence. 72. Determination of immobilized DNA and C-reactive protein on Au(111) electrodes using tris(2,2'-bipyridyl)ruthenium(II) labels.

  Analytical chemistry 20031101

• Covalent immobilization of chitosan and heparin on PLGA surface.

  International journal of biological macromolecules 20031101

• Biomimetic surface modification of poly (L-lactic acid) with gelatin and its effects on articular chondrocytes in vitro.

  Journal of biomedical materials research. Part A 20030915

• Biomimetic surface modification of poly(L-lactic acid) with chitosan and its effects on articular chondrocytes in vitro.

  Biomaterials 20030901

• Surface functionalization and grafting of heparin and/or RGD by an aqueous-based process to a poly(carbonate-urea)urethane cardiovascular graft for cellular engineering applications.

  Journal of biomedical materials research. Part A 20030901

• Alloantigen presentation by ethylcarbodiimide-treated dendritic cells induces T cell hyporesponsiveness, and prolongs organ graft survival.

  Clinical immunology (Orlando, Fla.) 20030901

• Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies.

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  International journal of pharmaceutics 20030709

• Horseradish peroxidase immobilized through its carboxylic groups onto a polyacrylonitrile membrane: comparison of enzyme performances with inorganic beaded supports.

  Applied biochemistry and biotechnology 20030701

• Immunosensor for detection of Legionella pneumophila using surface plasmon resonance.

  Biosensors & bioelectronics 20030501

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  European journal of biochemistry 20030301

• Carboxylate groups on the manganese-stabilizing protein are required for efficient binding of the 24 kDa extrinsic protein to photosystem II.

  Biochemistry 20030225

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  Analytical biochemistry 20030201

• Functional stabilization of trypsin by conjugation with beta-cyclodextrin-modified carboxymethylcellulose.

  Preparative biochemistry & biotechnology 20030201

• The influence of glycosaminoglycans and crosslinking agents on the phenotype of hepatocytes cultured on collagen gels.

  Human & experimental toxicology 20030201

• Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery.

  International journal of pharmaceutics 20030102

• Galactose-substituted alginate: preliminary characterization and study of gelling properties.

  Biomacromolecules 20030101

• New cationized LDL-DNA complexes: their targeted delivery to fibroblasts in culture.

  Drug delivery 20030101

• Enhancement effect of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and cationic surfactant on the chemiluminescence of poly(3, 4, 5-trihydroxybenzoate ester)dendrimers.

  Luminescence : the journal of biological and chemical luminescence 20030101

• Polyacetal-doxorubicin conjugates designed for pH-dependent degradation.

  Bioconjugate chemistry 20030101

• Identification of functionally important acidic residues in transducin by group-specific labeling.

  Biological research 20030101

• Biochemical and structural characterization of the cross-linked complex of nitrogenase: comparison to the ADP-AlF4(-)-stabilized structure.

  Biochemistry 20021231

• Surface modification of polycaprolactone with poly(methacrylic acid) and gelatin covalent immobilization for promoting its cytocompatibility.

  Biomaterials 20021201

• Polymerized degradable hyaluronan--a platform for stent coating with inherent inhibitory effects on neointimal formation in a porcine coronary model.

  The International journal of artificial organs 20021201

• Further stabilization of earthworm serine protease by chemical modification and immobilization.

  Bioscience, biotechnology, and biochemistry 20021201

• Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity.

  The Journal of biological chemistry 20021122

• Evidence that phosphate release is the rate-limiting step on the overall ATPase of psoas myofibrils prevented from shortening by chemical cross-linking.

  Biochemistry 20021105

• Kinetic studies on the rate of hydrolysis of N-ethyl-N'-(dimethylaminopropyl)carbodiimide in aqueous solutions using mass spectrometry and capillary electrophoresis.

  Analytical biochemistry 20021101

• Characterization of three regulatory states of the striated muscle thin filament.

  Journal of molecular biology 20021025

• Ultrathin layered myoglobin-polyion films functional and stable at acidic pH values.

  Journal of the American Chemical Society 20021023

• Analysis of aminofluorescein-fatty acid derivatives by capillary electrophoresis with laser-induced fluorescence detection at the attomole level: application to mycobacterial fatty acids.

  Journal of chromatography. A 20021011

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• Sequential robust design methodology and X-ray photoelectron spectroscopy to analyze the grafting of hyaluronic acid to glass substrates.

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• Preparation and characterization of immunogens for antibody production against metanephrine and normetanephrine.

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• Synthesis and characterization of oligomaltose-grafted lipids with application to liposomes.

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  Biochemistry 20020730

• Self-contained microelectrochemical immunoassay for small volumes using mouse IgG as a model system.

  Analytical chemistry 20020715

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  Artificial cells, blood substitutes, and immobilization biotechnology 20020701

• A novel ultraviolet assay for testing side reactions of carbodiimides.

  Analytical biochemistry 20020615

• Development of 7-(N,N-dimethylaminosulfonyl)-5-N-(4-N-aminoethyl)piperazino-2,1,3-benzoxadiazole as a water-soluble fluorogenic reagent for the sensitive liquid chromatographic determination of saturated carboxylic acids.

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• A cross-linked profilin-actin heterodimer interferes with elongation at the fast-growing end of F-actin.

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• Investigation of the electron-transfer mechanism by cross-linking between Zn-substituted myoglobin and cytochrome b(5).

  Journal of the American Chemical Society 20020417

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• Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linking.

  Biomaterials 20020201

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  Biomaterials 20020101

• Novel functional biodegradable polymer: synthesis and anticoagulant activity of poly(gamma-glutamic acid)sulfonate (gamma-PGA-sulfonate).

  Bioconjugate chemistry 20020101

• A mid-IR flow-through sensor for direct monitoring of enzyme catalysed reactions. Case study: Measurement of carbohydrates in beer.

  The Analyst 20020101

• Cytotoxicity evaluation of gelatin sponges prepared with different cross-linking agents.

  Journal of biomaterials science. Polymer edition 20020101

• The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis.

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• Enzymatic properties of sialic acid binding lectin from Rana catesbeiana modified with a water-soluble carbodiimide in the presence of various nucleophiles.

  Biological & pharmaceutical bulletin 20011201

• Conjugation of monoclonal antibodies with TETA using activated esters: biological comparison of 64Cu-TETA-1A3 with 64Cu-BAT-2IT-1A3.

  Cancer biotherapy & radiopharmaceuticals 20011201

• Direct DNA hybridization detection based on the oligonucleotide-functionalized conductive polymer.

  Analytical chemistry 20011115

• Self-assembled monolayers as the coating in a quartz piezoelectric crystal immunosensor to detect Salmonella in aqueous solution.

  Analytical chemistry 20011101

• Thiolation of polycarbophil enhances its inhibition of intestinal brush border membrane bound aminopeptidase N.

  Journal of pharmaceutical sciences 20011101

• Development of affinity microparticles for extracorporeal blood purification based on crystalline bacterial cell surface proteins.

  Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis 20011001

• New antibody purification procedure using a thermally responsive poly(N-isopropylacrylamide)-dextran derivative conjugate.

  Journal of chromatography. B, Biomedical sciences and applications 20010925

• Allophycocyanin 1 as a near-infrared fluorescent tracer: isolation, characterization, chemical modification, and use in a homogeneous fluorescence resonance energy transfer system.

  Analytical biochemistry 20010915

• The influence of crosslinking agents and diamines on the pore size, morphology and the biological stability of collagen sponges and their effect on cell penetration through the sponge matrix.

  Journal of materials science. Materials in medicine 20010901

• Relation between cell density and the secretion of von Willebrand factor and prostacyclin by human umbilical vein endothelial cells.

  Biomaterials 20010801

• Binding and release of basic fibroblast growth factor from heparinized collagen matrices.

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• Functional dissection of trigger factor and DnaK: interactions with nascent polypeptides and thermally denatured proteins.

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• Mapping protein interfaces with a fluorogenic cross-linker and mass spectrometry: application to nebulin-calmodulin complexes.

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• Effects of carbodiimide crosslinking conditions on the physical properties of laminated intestinal submucosa.

  Journal of biomedical materials research 20010701

• ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.

  American journal of physiology. Cell physiology 20010701

• Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups.

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  Journal of biomedical materials research 20010605

• Cross-linking by 1-ethyl-3- (3-dimethylaminopropyl)-carbodiimide (EDC) of a collagen/elastin membrane meant to be used as a dermal substitute: effects on physical, biochemical and biological features in vitro.

  Journal of materials science. Materials in medicine 20010501

• Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology.

  Analytical biochemistry 20010415

• Insights into the reaction mechanism of the diisopropyl fluorophosphatase from Loligo vulgaris by means of kinetic studies, chemical modification and site-directed mutagenesis.

  Biochimica et biophysica acta 20010407

• Interaction of the N-terminal part of the A1 essential light chain with the myosin heavy chain.

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• Functional role of the C-terminal domain of smooth muscle myosin light chain kinase on the phosphorylation of smooth muscle myosin.

  Journal of biochemistry 20010301

• Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system.

  European journal of biochemistry 20010301

• Cooperativity and substrate specificity of an alkaline amylase and neopullulanase complex of Micrococcus halobius OR-1.

  Applied biochemistry and biotechnology 20010301

• Optimizing the immobilization of single-stranded DNA onto glass beads.

  Journal of biochemical and biophysical methods 20010226

• Determination of alcohols by high-performance liquid chromatography with fluorimetric detection after pre-column derivatisation with carbazole-9-N-acetic acid and chromatographic behaviour of alcoholic derivatives.

  Journal of chromatography. A 20010216

• In vivo and in vitro measurement of apoptosis in breast cancer cells using 99mTc-EC-annexin V.

  Cancer biotherapy & radiopharmaceuticals 20010201

• X-ray diffraction evidence for the lack of stereospecific protein interactions in highly activated actomyosin complex.

  Journal of molecular biology 20010126

• Synthesis of novel ganglioside GM4 analogues containing N-deacetylated and lactamized sialic acid: probes for searching new ligand structures for human L-selectin.

  Carbohydrate research 20010115

• Immobilization of heparin to EDC/NHS-crosslinked collagen. Characterization and in vitro evaluation.

  Biomaterials 20010101

• The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates.

  Journal of experimental botany 20010101

• Electrochemical detection of sequence-specific DNA using a DNA probe labeled with aminoferrocene and chitosan modified electrode immobilized with ssDNA.

  The Analyst 20010101

• Formulation and release characteristics of poly(lactic-co-glycolic acid) microspheres containing chemically modified protein.

  The Journal of pharmacy and pharmacology 20010101

• Control of pH alters the type of cross-linking produced by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) treatment of acellular matrix vascular grafts.

  Journal of biomedical materials research 20010101