19210-12-9 | Harpagoside

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$23.00	$16.00
5mg	99%	in stock	$48.00	$33.00

Description

• Catalog Number: AD32257
• Chemical Name: Harpagoside
• CAS Number: 19210-12-9
• Molecular Formula: C24H30O11
• Molecular Weight: 494.4884
• MDL Number: MFCD00017415
• SMILES: OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@@]3([C@H]2[C@@](C)(OC(=O)/C=C/c2ccccc2)C[C@H]3O)O)[C@@H]([C@H]([C@@H]1O)O)O

Computed Properties

• Complexity: 811
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 10
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 7
• XLogP3: -0.6

Literature

• Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography.

  Journal of separation science 20121001

• Effect of silymarin and harpagoside on inflammation reaction of BEAS-2B cells, on ciliary beat frequency (CBF) of trachea explants and on mucociliary clearance (MCC).

  Planta medica 20120501

• Antiinflammatory activities of Hungarian Stachys species and their iridoids.

  Phytotherapy research : PTR 20120401

• Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor.

  Journal of neurochemistry 20120301

• Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics.

  Phytochemistry 20111101

• [Determination of harpagide and harpagoside in Scrophulariae Radix by HPLC-UV].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001

• Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.

  Bioorganic & medicinal chemistry 20110815

• Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl.

  Journal of agricultural and food chemistry 20110309

• [Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

• The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations.

  The Journal of pharmacy and pharmacology 20110301

• Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay.

  Phytotherapy research : PTR 20100901

• Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages.

  Journal of natural medicines 20100401

• Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw).

  Phytotherapy research : PTR 20100301

• Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201

• Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.

  Journal of natural products 20091201

• An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090315

• [Study on preparation and quantity determination of Scrophularia ningpoensis dispensing granules].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090101

• Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis.

  Natural product research 20090101

• Validated HPTLC methods for the determination of salicin in Salix sp. and of harpagoside in Harpagophytum [corrected] procumbens.

  Journal of pharmaceutical and biomedical analysis 20081104

• Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.

  European journal of pharmacology 20080624

• Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro.

  Journal of natural products 20080501

• Optimization of solid-phase extraction for the liquid chromatography-mass spectrometry analysis of harpagoside, 8-para-coumaroyl harpagide, and harpagide in equine plasma and urine.

  Journal of chromatographic science 20080201

• Simultaneous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies.

  Biomedical chromatography : BMC 20080101

• Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study.

  Analytical and bioanalytical chemistry 20071201

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.

  Journal of ethnopharmacology 20060308

• High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens.

  Phytochemical analysis : PCA 20060101

• Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma.

  Rapid communications in mass spectrometry : RCM 20060101

• Preparative isolation and purification of harpagoside from Scrophularia ningpoensis hemsley by high-speed counter-current chromatography.

  Phytochemical analysis : PCA 20060101

• Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (devil's claw) root.

  Journal of agricultural and food chemistry 20050504

• Comparison between HPLC and HPTLC-densitometry for the determination of harpagoside from Harpagophytum procumbens CO(2)-extracts.

  Journal of pharmaceutical and biomedical analysis 20050401

• Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy.

  Biopolymers 20050101

• A 1-year follow-up after a pilot study with Doloteffin for low back pain.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20050101

• Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20041101

• Effectiveness of Harpagophytum extracts and clinical efficacy.

  Phytotherapy research : PTR 20040201

• Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review.

  BMC complementary and alternative medicine 20040101

• Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity.

  Biological & pharmaceutical bulletin 20030401

• Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.

  Journal of natural products 20021101

• De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC.

  Biological & pharmaceutical bulletin 20011101

• Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo.

  Clinical pharmacology and therapeutics 20010501

• Reports of equivalence trials should not mask negative or mediocre results.

  Joint, bone, spine : revue du rhumatisme 20010301