19545-26-7 | KY 12420

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$57.00	$40.00
5mg	98%	in stock	$120.00	$84.00
10mg	98%	in stock	$208.00	$146.00
20mg	>98.0%(HPLC)	in stock	$231.00	$162.00

Description

• Catalog Number: AI43997
• Chemical Name: KY 12420
• CAS Number: 19545-26-7
• Molecular Formula: C23H24O8
• Molecular Weight: 428.4319
• MDL Number: MFCD00133927
• SMILES: COC[C@H]1OC(=O)c2c3[C@@]1(C)C1=C(C(=O)c3oc2)[C@H]2[C@@](C[C@H]1OC(=O)C)(C)C(=O)CC2

Computed Properties

• Complexity: 921
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 5
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• XLogP3: 1.2

Literature

• Raffinose from Costus speciosus attenuates lipid synthesis through modulation of PPARs/SREBP1c and improves insulin sensitivity through PI3K/AKT.

  Chemico-biological interactions 20180325

• Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways.

  Toxicology in vitro : an international journal published in association with BIBRA 20170401

• Progesterone Protects Against Bisphenol A-Induced Arrhythmias in Female Rat Cardiac Myocytes via Rapid Signaling.

  Endocrinology 20170401

• Activation of G protein-coupled receptor 30 by thiodiphenol promotes proliferation of estrogen receptor α-positive breast cancer cells.

  Chemosphere 20170201

• Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells.

  The Journal of toxicological sciences 20170101

• G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.

  PloS one 20170101

• Nonylphenol induced apoptosis and autophagy involving the Akt/mTOR pathway in prepubertal Sprague-Dawley male rats in vivo and in vitro.

  Toxicology 20161212

• Mono(2-ethylhexyl)phthalate accumulation disturbs energy metabolism of fat cells.

  Archives of toxicology 20160301

• Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20160301

• Erk-Creb pathway suppresses glutathione-S-transferase pi expression under basal and oxidative stress conditions in zebrafish embryos.

  Toxicology letters 20160105

• Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.

  Scientific reports 20160101

• Cadmium promotes the proliferation of triple-negative breast cancer cells through EGFR-mediated cell cycle regulation.

  Toxicology and applied pharmacology 20151115

• Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Pathways.

  The Journal of biological chemistry 20150821

• Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells.

  Archives of toxicology 20150801

• Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.

  The Journal of biological chemistry 20150619

• Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

  Toxicological sciences : an official journal of the Society of Toxicology 20150601

• Filamin A phosphorylation by Akt promotes cell migration in response to arsenic.

  Oncotarget 20150520

• (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases.

  Chemical research in toxicology 20150518

• Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice.

  The Journal of biological chemistry 20150501

• Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.

  Toxicological sciences : an official journal of the Society of Toxicology 20150401

• FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells.

  Oncology letters 20150301

• Resveratrol induces cell apoptosis in adipocytes via AMPK activation.

  Biochemical and biophysical research communications 20150220

• Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver.

  PloS one 20150101

• Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus.

  Reproductive toxicology (Elmsford, N.Y.) 20141201

• Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity.

  Nucleic acids research 20141110

• Atrazine enhances progesterone production through activation of multiple signaling pathways in FSH-stimulated rat granulosa cells: evidence for premature luteinization.

  Biology of reproduction 20141101

• Dibutyltin promotes oxidative stress and increases inflammatory mediators in BV-2 microglia cells.

  Toxicology letters 20141015

• Coactivation of the PI3K/Akt and ERK signaling pathways in PCB153-induced NF-κB activation and caspase inhibition.

  Toxicology and applied pharmacology 20140615

• Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation.

  Cancer letters 20140501

• Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor models.

  Molecular cancer therapeutics 20140501

• Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na.

  Molecular cancer therapeutics 20140501

• Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20140401

• Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product.

  Toxicology and applied pharmacology 20140301

• Nicotine decreases the activity of glutamate transporter type 3.

  Toxicology letters 20140210

• AKT signaling is involved in fucoidan-induced inhibition of growth and migration of human bladder cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140201

• Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt.

  Frontiers in microbiology 20140101

• Oxidative stress parameters induced by exposure to either cadmium or 17β-estradiol on Mytilus galloprovincialis hemocytes. The role of signaling molecules.

  Aquatic toxicology (Amsterdam, Netherlands) 20140101

• Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium.

  Archives of toxicology 20131201

• Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II.

  Toxicology letters 20131125

• A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

  Toxicological sciences : an official journal of the Society of Toxicology 20131101

• The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard.

  Toxicology and applied pharmacology 20131015

• Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells.

  Toxicology letters 20131009

• Progesterone increases the activity of glutamate transporter type 3 expressed in Xenopus oocytes.

  European journal of pharmacology 20130905

• Role of AMP-activated protein kinase in ferritin H gene expression by resveratrol in human T cells.

  Biochemistry 20130730

• Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells.

  Chemico-biological interactions 20130705

• Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.

  Archives of toxicology 20130501

• Direct effects of Bisphenol A on lipid homeostasis in rat hepatoma cells.

  Chemosphere 20130501

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling.

  British journal of pharmacology 20130401

• ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation.

  Biochemical pharmacology 20130401

• Caffeine-induced inhibition of the activity of glutamate transporter type 3 expressed in Xenopus oocytes.

  Toxicology letters 20130227

• Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20130201

• Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum.

  Eukaryotic cell 20130201

• Aspidin PB, a phloroglucinol derivative, induces apoptosis in human hepatocarcinoma HepG2 cells by modulating PI3K/Akt/GSK3β pathway.

  Chemico-biological interactions 20130125

• Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20130101

• A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.

  PloS one 20130101

• The role of autophagy dysregulation in manganese-induced dopaminergic neurodegeneration.

  Neurotoxicity research 20130101

• An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism.

  PloS one 20130101

• Arsenite-induced stress signaling: modulation of the phosphoinositide 3'-kinase/Akt/FoxO signaling cascade.

  Redox biology 20130101

• Association of SIRT1 expression with shear stress induced endothelial progenitor cell differentiation.

  Journal of cellular biochemistry 20121201

• A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation.

  Biochimica et biophysica acta 20121201

• Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.

  Molecular & cellular proteomics : MCP 20121201

• Restoration of alveolar type II cell function contributes to simvastatin-induced attenuation of lung ischemia-reperfusion injury.

  International journal of molecular medicine 20121201

• Viridin analogs derived from steroidal building blocks.

  Bioorganic & medicinal chemistry letters 20121115

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes.

  The Journal of biological chemistry 20121102

• Akt or phosphoinositide-3-kinase inhibition reverses cardio-protection in Toll-like receptor 2 deficient mice.

  Resuscitation 20121101

• Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway.

  Journal of pineal research 20121101

• IL-6 augmented motility of airway epithelial cell BEAS-2B via Akt/GSK-3β signaling pathway.

  Journal of cellular biochemistry 20121101

• Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways.

  The international journal of biochemistry & cell biology 20121101

• Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.

  The international journal of biochemistry & cell biology 20121101

• Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor.

  The American journal of pathology 20121101

• The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling.

  Circulation research 20121026

• PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.

  Journal of medicinal chemistry 20121025

• Uptake of fluorescent nano beads into BY2-cells involves clathrin-dependent and clathrin-independent endocytosis.

  FEBS letters 20121019

• Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca(2+) influx.

  Biochemical pharmacology 20121015

• Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca(2+) current.

  Biochemical pharmacology 20121015

• Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus.

  American journal of physiology. Regulatory, integrative and comparative physiology 20121015

• Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line.

  Toxicology and applied pharmacology 20121015

• Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.

  Journal of immunology (Baltimore, Md. : 1950) 20121015

• A procyanidin trimer, C1, promotes NO production in rat aortic endothelial cells via both hyperpolarization and PI3K/Akt pathways.

  European journal of pharmacology 20121005

• Previous ischemia and reperfusion injury results in resistance of the kidney against subsequent ischemia and reperfusion insult in mice; a role for the Akt signal pathway.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20121001

• Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases.

  American journal of respiratory cell and molecular biology 20121001

• 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway.

  European journal of nutrition 20121001

• Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.

  Toxicon : official journal of the International Society on Toxinology 20121001

• Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis.

  Apoptosis : an international journal on programmed cell death 20121001

• Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.

  Behavioural brain research 20121001

• Pretreatment with intrathecal or intravenous morphine attenuates hepatic ischaemia-reperfusion injury in normal and cirrhotic rat liver.

  British journal of anaesthesia 20121001

• Glycogen synthase kinase-3β regulates anti-inflammatory property of fluoxetine.

  International immunopharmacology 20121001

• Losartan, an angiotensin II type 1 receptor blocker, ameliorates cerebral ischemia-reperfusion injury via PI3K/Akt-mediated eNOS phosphorylation.

  Brain research bulletin 20121001

• A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.

  The Biochemical journal 20121001

• Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola.

  Fitoterapia 20121001

• A method for the establishment of a cell line with stable expression of the GFP-LC3 reporter protein.

  Molecular medicine reports 20121001

• Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.

  Toxicology and applied pharmacology 20121001

• Inhibition of phosphoinositide-3 kinase pathway down regulates ABCG2 function and sensitizes malignant pleural mesothelioma to chemotherapy.

  Lung cancer (Amsterdam, Netherlands) 20121001

• Involvement of ROS in the inhibitory effect of thermotherapy combined with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt pathway.

  Oncology reports 20121001

• Thymosin β4 and cardiac protection: implication in inflammation and fibrosis.

  Annals of the New York Academy of Sciences 20121001

• [Effects of PI3K/AKT inhibitor wortmannin on proliferation and apoptosis of primary porcine preadipocytes].

  Yi chuan = Hereditas 20121001

• Hydrogen sulfide regulates cardiac sarcoplasmic reticulum Ca(2+) uptake via K(ATP) channel and PI3K/Akt pathway.

  Life sciences 20120917

• Endothelin-1 stimulates suppressor of cytokine signaling-3 gene expression in adipocytes.

  General and comparative endocrinology 20120915

• Preconditioning with periodic acceleration (pGz) provides second window of cardioprotection.

  Life sciences 20120904

• Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression.

  The Journal of nutritional biochemistry 20120901

• Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α.

  The Journal of nutritional biochemistry 20120901

• Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats.

  Clinical science (London, England : 1979) 20120901

• Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.

  Hypertension research : official journal of the Japanese Society of Hypertension 20120901

• Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation.

  Basic research in cardiology 20120901

• Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

  Bioorganic & medicinal chemistry letters 20120901

• The proliferative effects of ghrelin on human gastric cancer AGS cells.

  Journal of digestive diseases 20120901

• Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury.

  Journal of veterinary science 20120901

• Translational regulation of the serum- and glucocorticoid-inducible kinase-1 (SGK1) in platelets.

  Biochemical and biophysical research communications 20120817

• Cyclic mechanical strain maintains Nanog expression through PI3K/Akt signaling in mouse embryonic stem cells.

  Experimental cell research 20120815

• The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice.

  European journal of pharmacology 20120815

• Regulation of cyclin T1 expression and function by an alternative splice variant that skips exon 7 and contains a premature termination codon.

  Gene 20120815

• TG-interacting factor-induced superoxide production from NADPH oxidase contributes to the migration/invasion of urothelial carcinoma.

  Free radical biology & medicine 20120815

• Globular adiponectin activates Akt in cultured myocytes.

  Biochemical and biophysical research communications 20120810

• Gemfibrozil, a lipid-lowering drug, induces suppressor of cytokine signaling 3 in glial cells: implications for neurodegenerative disorders.

  The Journal of biological chemistry 20120803

• Effects of C-reactive protein on adipokines genes expression in 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20120803

• The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3.

  The international journal of neuropsychopharmacology 20120801

• Induction of autophagy by amino acid starvation in fish cells.

  Marine biotechnology (New York, N.Y.) 20120801

• Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A) receptor-operated native TRPC channels in rabbit coronary artery myocytes.

  British journal of pharmacology 20120801

• A role of autophagy in Trypanosoma brucei cell death.

  Cellular microbiology 20120801

• Effects of pregabalin on the activity of glutamate transporter type 3.

  British journal of anaesthesia 20120801

• Ischemic postconditioning mediates cardioprotection via PI3K/GSK-3β/β-catenin signaling pathway in ischemic rat myocardium.

  Shock (Augusta, Ga.) 20120801

• Picroside II protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by activating the PI3K/Akt and CREB pathways.

  International journal of molecular medicine 20120801

• Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.

  Cytokine 20120801

• Differential effects of arsenic on calcium signaling in primary keratinocytes and malignant (HSC-1) cells.

  Cell calcium 20120801

• PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt.

  Canadian journal of physiology and pharmacology 20120801

• Irreversible protein kinase inhibitors: balancing the benefits and risks.

  Journal of medicinal chemistry 20120726

• Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120725

• Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway.

  Molecular and cellular endocrinology 20120706

• Role of Akt-dependent pathway in resveratrol-mediated cardioprotection after trauma-hemorrhage.

  The Journal of surgical research 20120701

• Vacuolar degradation of two integral plasma membrane proteins, AtLRR84A and OsSCAMP1, is cargo ubiquitination-independent and prevacuolar compartment-mediated in plant cells.

  Traffic (Copenhagen, Denmark) 20120701

• Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation.

  International journal of molecular medicine 20120701

• Estrogen potentiates prostaglandin E₂-stimulated duodenal mucosal HCO₃⁻ secretion in mice.

  American journal of physiology. Endocrinology and metabolism 20120701

• Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway.

  Medical hypotheses 20120701

• Tropisetron attenuates cardiac injury in a rat trauma-hemorrhage model.

  Shock (Augusta, Ga.) 20120701

• Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway.

  American journal of physiology. Lung cellular and molecular physiology 20120701

• PKC signaling is involved in the regulation of progranulin (acrogranin/PC-cell-derived growth factor/granulin-epithelin precursor) protein expression in human ovarian cancer cell lines.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120701

• Postconditioning with glucagon like peptide-2 reduces ischemia/reperfusion injury in isolated rat hearts: role of survival kinases and mitochondrial KATP channels.

  Basic research in cardiology 20120701

• Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways.

  Acta pharmacologica Sinica 20120701

• A priming role of local estrogen on exogenous estrogen-mediated synaptic plasticity and neuroprotection.

  Experimental & molecular medicine 20120630

• Involvement of phosphatidylinositol 3-kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells.

  Brain research 20120629

• Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia.

  Brain research 20120629

• Quantitative retinal protein analysis after optic nerve transection reveals a neuroprotective role for hepatoma-derived growth factor on injured retinal ganglion cells.

  Investigative ophthalmology & visual science 20120626

• Vasodilatory effects of ethanol extract of Radix Paeoniae Rubra and its mechanism of action in the rat aorta.

  Journal of ethnopharmacology 20120626

• PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice.

  Toxicology 20120614

• Hyaluronan-modified and regular multilamellar liposomes provide sub-cellular targeting to macrophages, without eliciting a pro-inflammatory response.

  Journal of controlled release : official journal of the Controlled Release Society 20120610

• Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.

  The Journal of biological chemistry 20120608

• ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling.

  The Journal of biological chemistry 20120608

• Prolactin regulates tuberoinfundibular dopamine neuron discharge pattern: novel feedback control mechanisms in the lactotrophic axis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120606

• The biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome.

  Medical oncology (Northwood, London, England) 20120601

• Adenosine-5'-triphosphate up-regulates proliferation of human cardiac fibroblasts.

  British journal of pharmacology 20120601

• Downregulation of ErbB3 by Wnt3a contributes to wnt-induced osteoblast differentiation in mesenchymal cells.

  Journal of cellular biochemistry 20120601

• Cadherin switch from E- to N-cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail.

  The British journal of dermatology 20120601

• Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.

  Journal of cell science 20120601

• Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection.

  Cardiovascular drugs and therapy 20120601

• On-chip microelectrophoresis for the study of in vitro nonhomologous end-joining DNA double-strand break repair.

  Analytical biochemistry 20120601

• Ischemic postconditioning through percutaneous transluminal coronary angioplasty in pigs: roles of PI3K activation.

  Coronary artery disease 20120601

• The PI3K/Akt inhibitor LY294002 reverses BCRP-mediated drug resistance without affecting BCRP translocation.

  Oncology reports 20120601

• EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway.

  Carcinogenesis 20120601

• Excitation-contraction coupling in ventricular myocytes is enhanced by paracrine signaling from mesenchymal stem cells.

  Journal of molecular and cellular cardiology 20120601

• Biphasic regulation of P-glycoprotein function and expression by NO donors in Caco-2 cells.

  Acta pharmacologica Sinica 20120601

• E-cadherin promotes proliferation of human ovarian cancer cells in vitro via activating MEK/ERK pathway.

  Acta pharmacologica Sinica 20120601

• Dual role of IGF-II in oocyte maturation in southern flounder Paralichthys lethostigma: up-regulation of mPRα and resumption of meiosis.

  General and comparative endocrinology 20120601

• Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway.

  International journal of cardiology 20120531

• Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells.

  The Journal of biological chemistry 20120518

• Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway.

  Neuroscience 20120517

• Site-specific regulation of ion transport by prolactin in rat colon epithelium.

  American journal of physiology. Gastrointestinal and liver physiology 20120515

• Serotonin inhibits low-threshold spike interneurons in the striatum.

  The Journal of physiology 20120515

• Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats.

  World journal of gastroenterology 20120514

• The gastrointestinal peptide obestatin induces vascular relaxation via specific activation of endothelium-dependent NO signalling.

  British journal of pharmacology 20120501

• Puerarin protects differentiated PC12 cells from H₂O₂-induced apoptosis through the PI3K/Akt signalling pathway.

  Cell biology international 20120501

• 17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl(-) current in rabbit articular chondrocytes.

  British journal of pharmacology 20120501

• Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1).

  Molecular human reproduction 20120501

• Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores.

  Cellular signalling 20120501

• Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.

  Pharmacology, biochemistry, and behavior 20120501

• Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury.

  Kidney international 20120501

• P2X4 receptor channels form large noncytolytic pores in resting and activated microglia.

  Glia 20120501

• Evidence for phosphatidylinositol-3-OH-kinase (PI3-kinase) involvement in Cd-mediated oxidative effects on hemocytes of mussels.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120501

• 17β-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K/Akt in female rat anterior pituitary cell culture.

  American journal of physiology. Endocrinology and metabolism 20120501

• Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.

  Biochimica et biophysica acta 20120501

• Lipopolysaccharide-induced stem cell factor messenger RNA expression and production in odontoblast-like cells.

  Journal of endodontics 20120501

• Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation.

  PLoS biology 20120501

• Role of keratinocytes in the development of vitiligo.

  Annals of dermatology 20120501

• Induction of melanogenesis by rapamycin in human MNT-1 melanoma cells.

  Annals of dermatology 20120501

• Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.

  PLoS pathogens 20120501

• cAMP and EPAC are key players in the regulation of the signal transduction pathway involved in the α-hemolysin autophagic response.

  PLoS pathogens 20120501

• Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration.

  The Journal of biological chemistry 20120427

• Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.

  The Journal of biological chemistry 20120420

• PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter.

  Biochemical and biophysical research communications 20120420

• γH2AX, pChk1, and Wip1 as potential markers of persistent DNA damage derived from dibenzo[a,l]pyrene and PAH-containing extracts from contaminated soils.

  Chemical research in toxicology 20120416

• Hydrogen peroxide enhances the expression of Giα proteins in aortic vascular smooth cells: role of growth factor receptor transactivation.

  American journal of physiology. Heart and circulatory physiology 20120415

• Signal transduction pathways in FSH regulation of rat Sertoli cell proliferation.

  American journal of physiology. Endocrinology and metabolism 20120415

• Antigen-presenting cell marker expression and phagocytotic activity in periodontal ligament cells.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120401

• The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling.

  Biological psychiatry 20120401

• Investigating the signal transduction pathways underlying remote ischemic conditioning in the porcine heart.

  Cardiovascular drugs and therapy 20120401

• Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity.

  Journal of pineal research 20120401

• TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori.

  Insect biochemistry and molecular biology 20120401

• The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways.

  Diabetologia 20120401

• The role of CD147 in the invasiveness of follicular thyroid carcinoma cells.

  Thyroid : official journal of the American Thyroid Association 20120401

• Cell type influences the molecular mechanisms involved in hormonal regulation of ERG K+ channels.

  Pflugers Archiv : European journal of physiology 20120401

• Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.

  Autophagy 20120401

• Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.

  PLoS pathogens 20120401

• Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis.

  PLoS pathogens 20120401

• Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase.

  Experimental & molecular medicine 20120331

• p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest.

  Experimental & molecular medicine 20120331

• LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism.

  FEBS letters 20120323

• Reconstitution of the cellular response to DNA damage in vitro using damage-activated extracts from mammalian cells.

  Experimental cell research 20120310

• Regulatory mechanisms of interleukin-8 production induced by tumour necrosis factor-α in human hepatocellular carcinoma cells.

  Journal of cellular and molecular medicine 20120301

• Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes.

  Glia 20120301

• EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.

  American journal of physiology. Gastrointestinal and liver physiology 20120301

• α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage.

  Stroke 20120301

• Natural products as kinase inhibitors.

  Natural product reports 20120301

• Differential effects of LY294002 and wortmannin on inducible nitric oxide synthase expression in glomerular mesangial cells.

  International immunopharmacology 20120301

• Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.

  Epilepsia 20120301

• Arabidopsis type-III phosphatidylinositol 4-kinases β1 and β2 are upstream of the phospholipase C pathway triggered by cold exposure.

  Plant & cell physiology 20120301

• Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival?

  Experimental neurobiology 20120301

• Targeted therapy for hepatocellular carcinoma: novel agents on the horizon.

  Oncotarget 20120301

• DNA damage responses in cells exposed to sulphur mustard.

  Toxicology letters 20120225

• Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.

  The Journal of biological chemistry 20120224

• An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120222

• Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo.

  The Biochemical journal 20120215

• 17β-Estradiol attenuates the activity of the glutamate transporter type 3 expressed in Xenopus oocytes.

  European journal of pharmacology 20120215

• Surface plasmon resonance-biosensor detects the diversity of responses against epidermal growth factor in various carcinoma cell lines.

  Biosensors & bioelectronics 20120215

• Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes.

  Biochemical and biophysical research communications 20120210

• The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling.

  Chemico-biological interactions 20120205

• PI3-kinase regulates eosinophil and neutrophil degranulation in patients with allergic rhinitis and allergic asthma irrespective of allergen challenge model.

  Inflammation 20120201

• Progesterone enhances vascular endothelial cell migration via activation of focal adhesion kinase.

  Journal of cellular and molecular medicine 20120201

• mTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection.

  Medical microbiology and immunology 20120201

• Cardioprotective effect of therapeutic hypothermia at 34°C against ischaemia/reperfusion injury mediated by PI3K and nitric oxide in a rat isolated heart model.

  Resuscitation 20120201

• Mitigation of H2O2-induced autophagic cell death by propofol in H9c2 cardiomyocytes.

  Cell biology and toxicology 20120201

• Simultaneously targeting bcl-2 and Akt pathways sensitizes nasopharyngeal carcinoma to tumor necrosis factor-related apoptosis-inducing ligand.

  Cancer biotherapy & radiopharmaceuticals 20120201

• Restriction of trophic factors and nutrients induces PARKIN expression.

  Neurogenetics 20120201

• Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage.

  Toxicology in vitro : an international journal published in association with BIBRA 20120201

• Diabetes is associated with impairment of uterine contractility and high Caesarean section rate.

  Diabetologia 20120201

• Gonadotropin-releasing hormone-I or -II interacts with IGF-I/Akt but not connexin 43 in human granulosa cell apoptosis.

  The Journal of clinical endocrinology and metabolism 20120201

• Storage globulins pass through the Golgi apparatus and multivesicular bodies in the absence of dense vesicle formation during early stages of cotyledon development in mung bean.

  Journal of experimental botany 20120201

• Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway.

  Biochimica et biophysica acta 20120201

• Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.

  Autophagy 20120201

• PI3K-like kinases restrain Pim gene expression in endothelial cells.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20120201

• Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of α- and β-adrenergic signalling.

  Experimental biology and medicine (Maywood, N.J.) 20120201

• Novel targeted therapies for mantle cell lymphoma.

  Oncotarget 20120201

• The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats.

  Experimental & molecular medicine 20120131

• Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.

  Journal of the American Chemical Society 20120118

• Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway.

  Free radical biology & medicine 20120115

• Serine-threonine kinase 38 is regulated by glycogen synthase kinase-3 and modulates oxidative stress-induced cell death.

  Free radical biology & medicine 20120115

• A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

  Toxicology and applied pharmacology 20120115

• Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.

  The Biochemical journal 20120115

• PI 3-kinase and PKCζ mediate insulin-induced potentiation of NMDA receptor currents in Xenopus oocytes.

  Brain research 20120113

• G-CSF downregulates natural killer cell-mediated cytotoxicity in donors for hematopoietic SCT.

  Bone marrow transplantation 20120101

• Comparison of cellular damage response to low-dose-rate 125I seed irradiation and high-dose-rate gamma irradiation in human lung cancer cells.

  Brachytherapy 20120101

• Thymus-expressed chemokine promotes survival of PC12 cells via PI3K pathway.

  Neurochemistry international 20120101

• The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas.

  Advances in hematology 20120101

• Phosphatidylinositol 3-kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats.

  Molecular and cellular biochemistry 20120101

• The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-β2 in human retinal pigment epithelial cells.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20120101

• Tamoxifen promotes superoxide production in platelets by activation of PI3-kinase and NADPH oxidase pathways.

  Thrombosis research 20120101

• Dynamic behavior of clathrin in Arabidopsis thaliana unveiled by live imaging.

  The Plant journal : for cell and molecular biology 20120101

• Regulation of cellular growth, apoptosis, and Akt activity in human U251 glioma cells by a combination of cisplatin with CRM197.

  Anti-cancer drugs 20120101

• Differential modulation of brainstem phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55,212-2 centrally mediated pressor response in conscious rats.

  The Journal of pharmacology and experimental therapeutics 20120101

• Akt activation is responsible for enhanced migratory and invasive behavior of arsenic-transformed human bronchial epithelial cells.

  Environmental health perspectives 20120101

• Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin.

  American journal of physiology. Cell physiology 20120101

• Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells.

  Cellular signalling 20120101

• Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ.

  Journal of neurophysiology 20120101

• Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.

  American journal of physiology. Heart and circulatory physiology 20120101

• Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.

  Clinical and experimental pharmacology & physiology 20120101

• The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism.

  Biochemical pharmacology 20120101

• Glucotoxicity and α cell dysfunction: involvement of the PI3K/Akt pathway in glucose-induced insulin resistance in rat islets and clonal αTC1-6 cells.

  Endocrine research 20120101

• Autophagy as a therapeutic target in diabetic nephropathy.

  Experimental diabetes research 20120101

• Notch-induced hIL-6 production facilitates the maintenance of self-renewal of hCD34+ cord blood cells through the activation of Jak-PI3K-STAT3 pathway.

  The American journal of pathology 20120101

• Erythropoietin induces positive inotropic and lusitropic effects in murine and human myocardium.

  Journal of molecular and cellular cardiology 20120101

• Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes.

  International immunopharmacology 20120101

• Caffeine-induced synaptic potentiation in hippocampal CA2 neurons.

  Nature neuroscience 20120101

• Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells.

  The Journal of pharmacy and pharmacology 20120101

• Chitin, chitinase responses, and invasive fungal infections.

  International journal of microbiology 20120101

• Targeting the Cellular Signaling: BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma.

  Dermatology research and practice 20120101

• A searchable cross-platform gene expression database reveals connections between drug treatments and disease.

  BMC genomics 20120101

• LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling.

  Journal of inflammation (London, England) 20120101

• GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

  PloS one 20120101

• HGF-induced PKCζ activation increases functional CXCR4 expression in human breast cancer cells.

  PloS one 20120101

• Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury.

  PloS one 20120101

• Leptin: a novel therapeutic target in Alzheimer's disease?

  International journal of Alzheimer's disease 20120101

• Cardiac-specific expression of the tetracycline transactivator confers increased heart function and survival following ischemia reperfusion injury.

  PloS one 20120101

• Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line.

  PloS one 20120101

• Aristolochic acid I induced autophagy extenuates cell apoptosis via ERK 1/2 pathway in renal tubular epithelial cells.

  PloS one 20120101

• Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy.

  Journal of biomedical science 20120101

• Forms, crosstalks, and the role of phospholipid biosynthesis in autophagy.

  International journal of cell biology 20120101

• Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells.

  PloS one 20120101

• Insulin induces internalization of the plasma membrane 5-hydroxytryptamine2A (5-HT2A) receptor in the isolated human endothelium-denuded saphenous vein via the phosphatidylinositol 3-kinase pathway.

  Journal of pharmacological sciences 20120101

• Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles.

  Journal of nanobiotechnology 20120101

• Mulberry leaf extract stimulates glucose uptake and GLUT4 translocation in rat adipocytes.

  The American journal of Chinese medicine 20120101

• The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils.

  PloS one 20120101

• Injection of Pseudomonas aeruginosa Exo toxins into host cells can be modulated by host factors at the level of translocon assembly and/or activity.

  PloS one 20120101

• Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

  PloS one 20120101

• Nutraceutical approach for preventing obesity-related colorectal and liver carcinogenesis.

  International journal of molecular sciences 20120101

• Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway.

  Molecular pain 20120101

• Kaposi's Sarcoma Associated Herpesvirus Entry into Target Cells.

  Frontiers in microbiology 20120101

• Endogenous urotensin II selectively modulates erectile function through eNOS.

  PloS one 20120101

• An emerging role for the Mammalian target of rapamycin in 'pathological' protein translation: relevance to cocaine addiction.

  Frontiers in pharmacology 20120101

• TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activation.

  PloS one 20120101

• Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy.

  Neuropsychiatric disease and treatment 20120101

• Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells.

  PloS one 20120101

• HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway.

  Scientific reports 20120101

• (+)-Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice.

  PloS one 20120101

• JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction.

  PloS one 20120101

• The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system.

  Journal of neuroinflammation 20120101

• Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth.

  Cancer genomics & proteomics 20120101

• Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival.

  Theranostics 20120101

• Migration of Th1 lymphocytes is regulated by CD152 (CTLA-4)-mediated signaling via PI3 kinase-dependent Akt activation.

  PloS one 20120101

• Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes.

  PloS one 20120101

• Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD.

  PloS one 20120101

• Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.

  PloS one 20120101

• Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats.

  PloS one 20120101

• Increased migration of monocytes in essential hypertension is associated with increased transient receptor potential channel canonical type 3 channels.

  PloS one 20120101

• Phosphatidylinositol 3-kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity.

  PloS one 20120101

• Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica.

  Scientific reports 20120101

• Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury.

  Respiratory research 20120101

• Challenging New Targets for CNS-HIV Infection.

  Frontiers in neurology 20120101

• Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng.

  Mediators of inflammation 20120101

• Hybrid cells derived from breast epithelial cell/breast cancer cell fusion events show a differential RAF-AKT crosstalk.

  Cell communication and signaling : CCS 20120101

• Three-Axis Model for Atg Recruitment in Autophagy against Salmonella.

  International journal of cell biology 20120101

• PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis.

  Advances in hematology 20120101

• Novel therapies in glioblastoma.

  Neurology research international 20120101

• Current trends in targeted therapies for glioblastoma multiforme.

  Neurology research international 20120101

• Alternative macroautophagic pathways.

  International journal of cell biology 20120101

• Natural product extract of Dicksonia sellowiana induces endothelium-dependent relaxations by a redox-sensitive Src- and Akt-dependent activation of eNOS in porcine coronary arteries.

  Journal of vascular research 20120101

• Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin.

  PloS one 20120101

• Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells.

  PloS one 20120101

• Implications of therapy-induced selective autophagy on tumor metabolism and survival.

  International journal of cell biology 20120101

• Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface.

  PloS one 20120101

• CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.

  PloS one 20120101

• Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation.

  PloS one 20120101

• The role of phosphoinositide 3-kinase signaling in intestinal inflammation.

  Journal of signal transduction 20120101

• Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases.

  Mediators of inflammation 20120101

• Flavonoids inhibit the respiratory burst of neutrophils in mammals.

  Oxidative medicine and cellular longevity 20120101

• Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies.

  PloS one 20120101

• Perifosine as a potential novel anti-cancer agent inhibits EGFR/MET-AKT axis in malignant pleural mesothelioma.

  PloS one 20120101

• Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion.

  PloS one 20120101

• Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

  PloS one 20120101

• Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Mesangial medium from IgA nephropathy patients induces podocyte epithelial-to-mesenchymal transition through activation of the phosphatidyl inositol-3-kinase/Akt signaling pathway.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespan.

  PloS one 20120101

• CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.

  PloS one 20120101

• Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion.

  PloS one 20120101

• Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.

  PloS one 20120101

• A role for phosphoinositides in regulating plant nuclear functions.

  Frontiers in plant science 20120101

• Integrating body and organ size in Drosophila: recent advances and outstanding problems.

  Frontiers in endocrinology 20120101

• Metabolic Effects of Insulin and IGFs on Gilthead Sea Bream (Sparus aurata) Muscle Cells.

  Frontiers in endocrinology 20120101

• AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades.

  Neural plasticity 20120101

• Berbamine protects the heart from ischemia/reperfusion injury by maintaining cytosolic Ca(2+) homeostasis and preventing calpain activation.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Visualizing sweetness: increasingly diverse applications for fluorescent-tagged glucose bioprobes and their recent structural modifications.

  Sensors (Basel, Switzerland) 20120101

• Autophagy: more than a nonselective pathway.

  International journal of cell biology 20120101

• Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice.

  PloS one 20120101

• Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes.

  BioFactors (Oxford, England) 20120101

• New approach to beta cell function screening by nitric oxide assessment of obese individuals at the population level.

  International journal of general medicine 20120101

• GSK-3β: A Bifunctional Role in Cell Death Pathways.

  International journal of cell biology 20120101

• Cirsium japonicum flavones enhance adipocyte differentiation and glucose uptake in 3T3-L1 cells.

  Biological & pharmaceutical bulletin 20120101

• Hydra, a versatile model to study the homeostatic and developmental functions of cell death.

  The International journal of developmental biology 20120101

• Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods.

  PloS one 20120101

• Analyzing gene expression profile in K562 cells exposed to sodium valproate using microarray combined with the connectivity map database.

  Journal of biomedicine & biotechnology 20120101

• Think small: zebrafish as a model system of human pathology.

  Journal of biomedicine & biotechnology 20120101

• Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.

  International journal of biological sciences 20120101

• Regulation of organic cation transport in isolated mouse proximal tubules involves complex changes in protein trafficking and substrate affinity.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney.

  PloS one 20120101

• PI3K contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs.

  PloS one 20120101

• Wortmannin reduces metastasis and angiogenesis of human breast cancer cells via nuclear factor-κB-dependent matrix metalloproteinase-9 and interleukin-8 pathways.

  The Journal of international medical research 20120101

• Copper oxide nanoparticles induce autophagic cell death in A549 cells.

  PloS one 20120101

• Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells.

  PloS one 20120101

• Interferon gamma induces steroid sulfatase expression in human keratinocytes.

  Biological & pharmaceutical bulletin 20120101

• Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Persistent amplification of DNA damage signal involved in replicative senescence of normal human diploid fibroblasts.

  Oxidative medicine and cellular longevity 20120101

• Regulation of NF-κB activation through a novel PI-3K-independent and PKA/Akt-dependent pathway in human umbilical vein endothelial cells.

  PloS one 20120101

• Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice.

  PloS one 20120101

• α6 Integrin and CD44 enrich for a primary keratinocyte population that displays resistance to UV-induced apoptosis.

  PloS one 20120101

• Integrin αIIb-mediated PI3K/Akt activation in platelets.

  PloS one 20120101

• Wortmannin inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells.

  European journal of gynaecological oncology 20120101

• Targeting activation of specific NF-κB subunits prevents stress-dependent atherothrombotic gene expression.

  Molecular medicine (Cambridge, Mass.) 20120101

• Involvement of phosphatidylinositol 3-kinase/Akt pathway in gemcitabine-induced apoptosis-like cell death in insulinoma cell line INS-1.

  Biological & pharmaceutical bulletin 20120101

• Thimerosal-induced apoptosis in mouse C2C12 myoblast cells occurs through suppression of the PI3K/Akt/survivin pathway.

  PloS one 20120101

• Calbindin-D28K inhibits apoptosis in dopaminergic neurons by activation of the PI3-kinase-Akt signaling pathway.

  Neuroscience 20111229

• Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation.

  The Journal of biological chemistry 20111209

• p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis.

  Biochemical and biophysical research communications 20111209

• Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status.

  Investigational new drugs 20111201

• The novel function of advanced glycation end products in regulation of MMP-9 production.

  The Journal of surgical research 20111201

• Role of laminin-111 in neurotrophin-3 production of canine adipose-derived stem cells: involvement of Akt, mTOR, and p70S6K.

  Journal of cellular physiology 20111201

• CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway.

  Journal of cellular physiology 20111201

• Permissive effect of EGFR-activated pathways on RVI and their anti-apoptotic effect in hypertonicity-exposed mIMCD3 cells.

  Bioscience reports 20111201

• Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection.

  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20111201

• Transcriptional up-regulation of cell surface Na V 1.7 sodium channels by insulin-like growth factor-1 via inhibition of glycogen synthase kinase-3β in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion.

  Neuropharmacology 20111201

• Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.

  Neurobiology of aging 20111201

• Regulation of arterial blood pressure by Akt1-dependent vascular relaxation.

  Journal of molecular medicine (Berlin, Germany) 20111201

• mTHPC-based photodynamic therapy induction of autophagy and apoptosis in cultured cells in relation to mitochondria and endoplasmic reticulum stress.

  International journal of oncology 20111201

• Overexpression of Arabidopsis thaliana PTEN caused accumulation of autophagic bodies in pollen tubes by disrupting phosphatidylinositol 3-phosphate dynamics.

  The Plant journal : for cell and molecular biology 20111201

• α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats.

  Stroke 20111201

• Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy.

  Journal of molecular cell biology 20111201

• Visualization of parameter space for image analysis.

  IEEE transactions on visualization and computer graphics 20111201

• The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function.

  Acta pharmacologica Sinica 20111201

• Chemotactic effect of odorants and tastants on the ciliate Tetrahymena pyriformis.

  Journal of receptor and signal transduction research 20111201

• Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation.

  Autophagy 20111201

• Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide.

  Journal of endodontics 20111201

• Butyrate regulates leptin expression through different signaling pathways in adipocytes.

  Journal of veterinary science 20111201

• Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites.

  PLoS pathogens 20111201

• Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma.

  Cell death & disease 20111201

• [Biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome].

  Zhongguo shi yan xue ye xue za zhi 20111201

• DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death.

  Oncotarget 20111201

• Differential effects of CXCR4 antagonists on the survival and proliferation of myeloid leukemia cells in vitro.

  The Korean journal of hematology 20111201

• Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells.

  Chinese medical journal 20111201

• Induction of steroid sulfatase expression by tumor necrosis factor-α through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells.

  Experimental & molecular medicine 20111130

• Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol-3-kinase-independent manner.

  European journal of pharmacology 20111116

• Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells.

  Chemico-biological interactions 20111115

• Insulin resistance in equine digital vessel rings: an in vitro model to study vascular dysfunction in equine laminitis.

  Equine veterinary journal 20111101

• Thymoquinone-induced platelet apoptosis.

  Journal of cellular biochemistry 20111101

• Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells.

  Cytokine 20111101

• Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling.

  Journal of cellular biochemistry 20111101

• FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C₂C₁₂ muscle cells.

  American journal of physiology. Endocrinology and metabolism 20111101

• HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia.

  Cardiovascular research 20111101

• Motilin stimulates preadipocyte proliferation and differentiation and adipocyte lipid storage.

  American journal of physiology. Endocrinology and metabolism 20111101

• Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate.

  Autophagy 20111101

• Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111101

• Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells.

  Asian journal of andrology 20111101

• RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning.

  Basic research in cardiology 20111101

• Src kinase integrates PI3K/Akt and MAPK/ERK1/2 pathways in T3-induced Na-K-ATPase activity in adult rat alveolar cells.

  American journal of physiology. Lung cellular and molecular physiology 20111101

• U50,488H inhibits neutrophil accumulation and TNF-α induction induced by ischemia-reperfusion in rat heart.

  Cytokine 20111101

• Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes.

  Journal of dermatological science 20111101

• Transcriptional profiling of angiogenesis activities of calycosin in zebrafish.

  Molecular bioSystems 20111101

• Thymosin β4 activates integrin-linked kinase and decreases endothelial progenitor cells apoptosis under serum deprivation.

  Journal of cellular physiology 20111101

• Movement based artifacts may contaminate extracellular electrical recordings from GI muscles.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111101

• Modeling tumor invasion and metastasis in Drosophila.

  Disease models & mechanisms 20111101

• Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis.

  The Journal of infectious diseases 20111101

• Studies on the expression of fibroblast growth factor-2 from odontoblast-like cells.

  Journal of endodontics 20111101

• In situ quantitative imaging of cellular lipids using molecular sensors.

  Nature chemistry 20111101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.

  Oncotarget 20111101

• The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes.

  PLoS pathogens 20111101

• Computational modeling and analysis of insulin induced eukaryotic translation initiation.

  PLoS computational biology 20111101

• Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling.

  Biochemistry. Biokhimiia 20111101

• The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.

  Open biology 20111101

• Wnt5a potentiates U46619-induced platelet aggregation via the PI3K/Akt pathway.

  Molecules and cells 20111031

• Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.

  Nature chemical biology 20111023

• Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism.

  The Journal of biological chemistry 20111021

• In vitro and in vivo anti-melanoma action of metformin.

  European journal of pharmacology 20111015

• Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone: calcium inflow and electrophysiological changes.

  Life sciences 20111010

• Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.

  Nature neuroscience 20111009

• Protective effect of ginsenoside Rb1 against myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats.

  Molecular biology reports 20111001

• Salidroside protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via PI3K-Akt dependent pathway.

  DNA and cell biology 20111001

• Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21(cip).

  International journal of molecular medicine 20111001

• The functional role of PI3K in maintenance of blood pressure and baroreflex suppression in (mRen2)27 and mRen2.Lewis rat.

  Journal of cardiovascular pharmacology 20111001

• A homogeneous and nonisotopic assay for phosphatidylinositol 4-kinases.

  Analytical biochemistry 20111001

• QUASIMODO 3 (QUA3) is a putative homogalacturonan methyltransferase regulating cell wall biosynthesis in Arabidopsis suspension-cultured cells.

  Journal of experimental botany 20111001

• Nitric oxide production by a murine macrophage cell line (RAW264.7 cells) stimulated with Aggregatibacter actinomycetemcomitans surface-associated material.

  Anaerobe 20111001

• Efficient non-viral gene delivery mediated by nanostructured calcium carbonate in solution-based transfection and solid-phase transfection.

  Molecular bioSystems 20111001

• Inactivation of PTEN is responsible for the survival of Hep G2 cells in response to etoposide-induced damage.

  Mutation research 20111001

• Intermittent hypobaric hypoxia improves postischemic recovery of myocardial contractile function via redox signaling during early reperfusion.

  American journal of physiology. Heart and circulatory physiology 20111001

• Streptococcus sanguinis-induced cytokine release from platelets.

  Journal of thrombosis and haemostasis : JTH 20111001

• Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma.

  Molecular oncology 20111001

• Overexpression of CREG attenuates atherosclerotic endothelium apoptosis via VEGF/PI3K/AKT pathway.

  Atherosclerosis 20111001

• Vitellogenin mediates phagocytosis through interaction with FcγR.

  Molecular immunology 20111001

• Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.

  Nature medicine 20111001

• [Protection from pulmonary apoptosis: a new therapeutic choice for septic acute lung injury].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20111001

• [Regulatory effect of glucagon-like peptide-1 on cell proliferation of skeletal myoblast strain L6 and its possible signal mechanism].

  Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20111001

• Carboxymethylated chitosan stimulates proliferation of Schwann cells in vitro via the activation of the ERK and Akt signaling pathways.

  European journal of pharmacology 20110930

• Insulin growth factor promotes human corneal fibroblast network formation in vitro.

  Investigative ophthalmology & visual science 20110929

• Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt pathway.

  Biochemical and biophysical research communications 20110923

• AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors.

  Biological psychiatry 20110915

• LC, a novel estrone-rhein hybrid compound, promotes proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells.

  Molecular and cellular endocrinology 20110915

• The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110914

• Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells.

  Toxicology letters 20110910

• Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt.

  Biochemical and biophysical research communications 20110909

• Study on glucose transport in muscle cells by extracts from Mitragyna speciosa (Korth) and mitragynine.

  Natural product research 20110901

• Insulin and chromium picolinate induce translocation of CD36 to the plasma membrane through different signaling pathways in 3T3-L1 adipocytes, and with a differential functionality of the CD36.

  Biological trace element research 20110901

• Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons.

  Hippocampus 20110901

• GSK-3β is essential for physiological electric field-directed Golgi polarization and optimal electrotaxis.

  Cellular and molecular life sciences : CMLS 20110901

• Lipoteichoic acid promotes nuclear accumulation of β-catenin via AKT in human gingival fibroblasts.

  International immunopharmacology 20110901

• Low dose methamphetamine mediates neuroprotection through a PI3K-AKT pathway.

  Neuropharmacology 20110901

• Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells.

  The Biochemical journal 20110901

• Differential effects of amisulpride and haloperidol on dopamine D2 receptor-mediated signaling in SH-SY5Y cells.

  Neuropharmacology 20110901

• Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C.

  Journal of neurochemistry 20110901

• Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on phosphatidylinositol-3-kinase/Akt signaling.

  The Journal of surgical research 20110901

• Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.

  Journal of muscle research and cell motility 20110901

• Novel approach for interleukin-23 up-regulation in human dendritic cells and the impact on T helper type 17 generation.

  Immunology 20110901

• Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells.

  Thrombosis and haemostasis 20110901

• Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose-polymerase-mediated apoptosis under high-glucose stimulation.

  Acta biochimica et biophysica Sinica 20110901

• Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport.

  PLoS pathogens 20110901

• Microparticles from apoptotic platelets promote resident macrophage differentiation.

  Cell death & disease 20110901

• Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation.

  PLoS pathogens 20110901

• Inhibition of endocytic processes by photodynamic therapy.

  Lasers in surgery and medicine 20110901

• Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture.

  The EMBO journal 20110831

• SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.

  The Journal of biological chemistry 20110826

• A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.

  The Biochemical journal 20110815

• PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110815

• Both darbepoetin alfa and carbamylated erythropoietin prevent kidney graft dysfunction due to ischemia/reperfusion in rats.

  Transplantation 20110815

• Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway.

  The Journal of biological chemistry 20110812

• Astrocytes and pericytes cooperatively maintain a capillary-like structure composed of endothelial cells on gel matrix.

  Brain research 20110811

• Role of serum- and glucocorticoid-inducible kinase-1 in regulating torsion-induced apoptosis in rats.

  International journal of andrology 20110801

• Glucagon-like peptide-1 and candesartan additively improve glucolipotoxicity in pancreatic β-cells.

  Metabolism: clinical and experimental 20110801

• CTGF inhibits cell motility and COX-2 expression in oral cancer cells.

  International immunopharmacology 20110801

• Signalling pathways underlying structural plasticity of dendritic spines.

  British journal of pharmacology 20110801

• Ethanol enhances susceptibility to apoptotic cell death via down-regulation of autophagy-related proteins.

  Alcoholism, clinical and experimental research 20110801

• PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110801

• Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes.

  Cellular and molecular life sciences : CMLS 20110801

• Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis.

  European journal of immunology 20110801

• Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX.

  Leukemia 20110801

• Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts.

  International journal of oncology 20110801

• Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism.

  Hepatology (Baltimore, Md.) 20110801

• Inhibition of Francisella tularensis LVS infection of macrophages results in a reduced inflammatory response: evaluation of a therapeutic strategy for intracellular bacteria.

  FEMS immunology and medical microbiology 20110801

• AKT down-regulates insulin-like growth factor-1 receptor as a negative feedback.

  Journal of biochemistry 20110801

• Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes.

  Journal of lipid research 20110801

• Differential involvement of phosphoinositide 3-kinase in gonadotrophin-releasing hormone actions in gonadotrophs and somatotrophs of goldfish, Carassius auratus.

  Journal of neuroendocrinology 20110801

• Insulin targets the Na(+)/K(+) ATPase in enterocytes via PI3K, PKC, and MAPKS.

  Journal of receptor and signal transduction research 20110801

• Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.

  Nature immunology 20110801

• Resveratrol inhibits migration and Rac1 activation in EGF- but not PDGF-activated vascular smooth muscle cells.

  Molecular nutrition & food research 20110801

• Aristolochic acid induces apoptosis of human umbilical vein endothelial cells in vitro by suppressing PI3K/Akt signaling pathway.

  Acta pharmacologica Sinica 20110801

• Integrating signals from the T-cell receptor and the interleukin-2 receptor.

  PLoS computational biology 20110801

• The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.

  PLoS neglected tropical diseases 20110801

• Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20110801

• IGF-I Exerts an Anti-inflammatory Effect on Skeletal Muscle Cells through Down-regulation of TLR4 Signaling.

  Immune network 20110801

• Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions.

  Journal of agricultural and food chemistry 20110727

• Ginsenoside Rb1 prevents homocysteine-induced endothelial dysfunction via PI3K/Akt activation and PKC inhibition.

  Biochemical pharmacology 20110715

• Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.

  The Biochemical journal 20110715

• Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution.

  The Biochemical journal 20110715

• L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways.

  The Journal of biological chemistry 20110708

• Complex inhibitory effects of nitric oxide on autophagy.

  Molecular cell 20110708

• Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis.

  Injury 20110701

• PI3Kinase signaling in glioblastoma.

  Journal of neuro-oncology 20110701

• Orientin-induced cardioprotection against reperfusion is associated with attenuation of mitochondrial permeability transition.

  Planta medica 20110701

• Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart.

  Cardiovascular research 20110701

• Endocytosis of cationized ferritin in marginal cells of the stria vascularis is regulated by protein kinase, protein phosphatase, and MEK/ERK and PI3-K signaling pathways.

  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20110701

• A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin.

  British journal of pharmacology 20110701

• Enhanced contractility and myosin phosphorylation induced by Ca(2+)-independent MLCK activity in hypertensive rats.

  Cardiovascular research 20110701

• Role of G(i/o)-Src kinase-PI3K/Akt pathway and caveolin-1 in β₂-adrenoceptor coupling to endothelial NO synthase in mouse pulmonary artery.

  Cellular signalling 20110701

• Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO₃⁻ secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH.

  American journal of physiology. Cell physiology 20110701

• Attenuation of nitric oxide bioavailability in porcine aortic endothelial cells by classical swine fever virus.

  Archives of virology 20110701

• β-Catenin mediates cyclic strain-stimulated cardiomyogenesis in mouse embryonic stem cells through ROS-dependent and integrin-mediated PI3K/Akt pathways.

  Journal of cellular biochemistry 20110701

• The PI3K/Akt pathway is involved in early infection of some exogenous avian leukosis viruses.

  The Journal of general virology 20110701

• Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes.

  Molecular and cellular biochemistry 20110701

• A group IIA-secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways.

  Journal of leukocyte biology 20110701

• Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1.

  Apoptosis : an international journal on programmed cell death 20110701

• Urothelial cancer cell response to combination therapy of gemcitabine and TRAIL.

  International journal of oncology 20110701

• The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.

  Nature immunology 20110701

• ERK5: a novel IKKα-kinase in rat hippocampal neurons.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110701

• Involvement of reperfusion injury salvage kinases in preconditioning depends critically on the preconditioning stimulus.

  Experimental biology and medicine (Maywood, N.J.) 20110701

• Multiple signaling pathways involved in stimulation of osteoblast differentiation by N-methyl-D-aspartate receptors activation in vitro.

  Acta pharmacologica Sinica 20110701

• Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation.

  Neuroscience 20110630

• Coronary response to diadenosine tetraphosphate after ischemia-reperfusion in the isolated rat heart.

  European journal of pharmacology 20110625

• The semi-synthetic kaurane ent-16α-methoxykauran-19-oic acid induces vascular relaxation and hypotension in rats.

  European journal of pharmacology 20110625

• Receptor mediated endocytosis 8 is a novel PI(3)P binding protein regulated by myotubularin-related 2.

  FEBS letters 20110623

• Preventing H₂O₂-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone.

  Brain research 20110607

• A key role for KCl cotransport in cell volume regulation in human erythroleukemia cells.

  Life sciences 20110606

• Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells.

  Molecular and cellular endocrinology 20110606

• cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway.

  The Journal of biological chemistry 20110603

• Effects induced by inhibitors of the phosphatidylinositol 3-kinase/Akt and nitric oxide synthase/guanylyl cyclase pathways on the isometric contraction in rat aorta: a comparative study.

  Fundamental & clinical pharmacology 20110601

• Mild stretch activates cPLA2 in alveolar type II epithelial cells independently through the MEK/ERK and PI3K pathways.

  Biochimica et biophysica acta 20110601

• δ-Opioid receptors stimulate GLUT1-mediated glucose uptake through Src- and IGF-1 receptor-dependent activation of PI3-kinase signalling in CHO cells.

  British journal of pharmacology 20110601

• Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells.

  DNA and cell biology 20110601

• The molecular mechanism of acylation stimulating protein regulation of adipophilin and perilipin expression: involvement of phosphoinositide 3-kinase and phospholipase C.

  Journal of cellular biochemistry 20110601

• Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition.

  Anesthesiology 20110601

• Biologic activity of a dinuclear Pd(II)-spermine complex toward human breast cancer.

  Chemical biology & drug design 20110601

• PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.

  Biochimica et biophysica acta 20110601

• Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.

  Biochimica et biophysica acta 20110601

• Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma.

  Journal of gastroenterology 20110601

• Antiproliferative effect of estrogen in vascular smooth muscle cells is mediated by Kruppel-like factor-4 and manganese superoxide dismutase.

  Basic research in cardiology 20110601

• An ethanolic extract of Lindera obtusiloba stems causes NO-mediated endothelium-dependent relaxations in rat aortic rings and prevents angiotensin II-induced hypertension and endothelial dysfunction in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20110601

• VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.

  Journal of cell science 20110601

• Alpha-lipoic acid inhibits endoplasmic reticulum stress-induced cell death through PI3K/Akt signaling pathway in FRTL5 thyroid cells.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110601

• No role for early IGF-1 signalling in stimulating acute 'muscle building' responses.

  The Journal of physiology 20110601

• Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors.

  Current medicinal chemistry 20110601

• DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.

  PLoS genetics 20110601

• Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans.

  PLoS pathogens 20110601

• Productive parvovirus B19 infection of primary human erythroid progenitor cells at hypoxia is regulated by STAT5A and MEK signaling but not HIFα.

  PLoS pathogens 20110601

• The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

  PLoS biology 20110601

• Major role of the PI3K/Akt pathway in ischemic tolerance induced by sublethal oxygen-glucose deprivation in cortical neurons in vitro.

  Archives of pharmacal research 20110601

• Ribosomal Protein L19 and L22 Modulate TLR3 Signaling.

  Immune network 20110601

• Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling.

  Journal of the American College of Cardiology 20110531

• Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway.

  Brain research bulletin 20110530

• NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.

  Behavioural brain research 20110516

• Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat.

  Neuroscience letters 20110516

• Mitophagy selectively degrades individual damaged mitochondria after photoirradiation.

  Antioxidants & redox signaling 20110515

• Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway.

  European journal of pharmacology 20110511

• Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells.

  Cancer chemotherapy and pharmacology 20110501

• The role of the dopamine transporter in dopamine-induced DNA damage.

  Brain pathology (Zurich, Switzerland) 20110501

• Comparison of intracellular signalling by insulin and the hypermitogenic AspB10 analogue in MCF-7 breast adenocarcinoma cells.

  Journal of applied toxicology : JAT 20110501

• Effects of endosomal photodamage on membrane recycling and endocytosis.

  Photochemistry and photobiology 20110501

• Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.

  Current drug targets 20110501

• Glycogen synthase kinase-3 negatively regulates tissue factor expression in monocytes interacting with activated platelets.

  Journal of thrombosis and haemostasis : JTH 20110501

• Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity.

  Basic research in cardiology 20110501

• Adiponectin inhibits lipolysis in mouse adipocytes.

  Diabetes 20110501

• Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.

  Diabetes 20110501

• Hepatocyte growth factor inhibits anoikis of pancreatic carcinoma cells through phosphatidylinositol 3-kinase pathway.

  Pancreas 20110501

• [Effects of PI3K/Akt signaling pathway on learning and memory abilities in neonatal rats with hypoxic-ischemic brain damage].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110501

• A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling.

  Cell death & disease 20110501

• Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.

  Cell death & disease 20110501

• Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts.

  Korean journal of anesthesiology 20110501

• Effects of photodynamic therapy on the endocytic pathway.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110430

• Effects of retinol binding protein-4 on vascular endothelial cells.

  Biochemical and biophysical research communications 20110429

• Effects of erythropoietin on intracellular calcium concentration of rat primary cortical neurons.

  Brain research 20110428

• Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways.

  Experimental cell research 20110415

• Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway.

  Life sciences 20110411

• Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures.

  Brain research 20110406

• KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro.

  Journal of cellular physiology 20110401

• Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes.

  Biochimica et biophysica acta 20110401

• Melatonin protects against apoptotic and autophagic cell death in C2C12 murine myoblast cells.

  Journal of pineal research 20110401

• Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice.

  Pharmacology, biochemistry, and behavior 20110401

• Internalization of Sambucus nigra agglutinins I and II in insect midgut CF-203 cells.

  Archives of insect biochemistry and physiology 20110401

• Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.

  Immunology 20110401

• A screen for novel phosphoinositide 3-kinase effector proteins.

  Molecular & cellular proteomics : MCP 20110401

• Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways: implications for leptin as a regulator of short term satiety.

  The Journal of biological chemistry 20110401

• Stimulation of bursting in pre-Bötzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels.

  Journal of neurochemistry 20110401

• Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade.

  The Journal of clinical endocrinology and metabolism 20110401

• Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling.

  The Journal of physiology 20110401

• Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway.

  Glia 20110401

• The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway.

  Toxicology and applied pharmacology 20110401

• The identification of raptor as a substrate for p44/42 MAPK.

  Endocrinology 20110401

• Ceruloplasmin expression in rat liver cells is attenuated by insulin: role of FoxO transcription factors.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110401

• The KEEP ON GOING protein of Arabidopsis recruits the ENHANCED DISEASE RESISTANCE1 protein to trans-Golgi network/early endosome vesicles.

  Plant physiology 20110401

• Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20110401

• Mycobacterial Heparin-binding Hemagglutinin Antigen Activates Inflammatory Responses through PI3-K/Akt, NF-κB, and MAPK Pathways.

  Immune network 20110401

• Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.

  Cancer research 20110315

• Fungal recognition enhances mannose receptor shedding through dectin-1 engagement.

  The Journal of biological chemistry 20110311

• Regulation of mesenchymal stem cell activity by endothelial cells.

  Stem cells and development 20110301

• An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro.

  Phytotherapy research : PTR 20110301

• Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3K/AKT signaling and CD44/hyaluronan interaction.

  Journal of cellular physiology 20110301

• In vitro activation of murine peritoneal macrophages by recombinant YopJ: production of nitric oxide, proinflammatory cytokines and chemokines.

  Immunobiology 20110301

• L-arginine promotes DNA repair in cultured bronchial epithelial cells exposed to ozone: involvement of the ATM pathway.

  Cell biology international 20110301

• C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.

  Journal of biochemistry 20110301

• The mitogenic effect of testosterone and 17β-estradiol on airway smooth muscle cells.

  Steroids 20110301

• Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.

  Free radical biology & medicine 20110301

• Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori.

  Insect biochemistry and molecular biology 20110301

• Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle.

  Diabetes 20110301

• Ionizing radiation-induced TAp63α phosphorylation at C-terminal S/TQ motifs requires the N-terminal transactivation (TA) domain.

  Cell cycle (Georgetown, Tex.) 20110301

• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.

  Oncotarget 20110301

• Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.

  Aging 20110301

• Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway.

  PLoS pathogens 20110301

• PI-3K/AKT signal pathway modulates vascular smooth muscle cells migration under cyclic mechanical strain.

  VASA. Zeitschrift fur Gefasskrankheiten 20110301

• The cytoskeleton in papillomavirus infection.

  Viruses 20110301

• Targeted in vivo O-GlcNAc sensors reveal discrete compartment-specific dynamics during signal transduction.

  The Journal of biological chemistry 20110225

• High boron-induced ubiquitination regulates vacuolar sorting of the BOR1 borate transporter in Arabidopsis thaliana.

  The Journal of biological chemistry 20110225

• A novel role of thrombopoietin as a physiological modulator of coronary flow.

  Regulatory peptides 20110225

• Macrophage-induced preadipocyte survival depends on signaling through Akt, ERK1/2, and reactive oxygen species.

  Experimental cell research 20110215

• Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.

  Cell cycle (Georgetown, Tex.) 20110215

• Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.

  The Journal of biological chemistry 20110211

• IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways.

  Brain research 20110210

• Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110209

• Neuroprotective effects of KR-62980, a new PPARγ agonist, against chemical ischemia-reperfusion in SK-N-SH cells.

  Brain research 20110204

• Activation of Akt protects alveoli from neonatal oxygen-induced lung injury.

  American journal of respiratory cell and molecular biology 20110201

• Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis.

  Digestive diseases and sciences 20110201

• Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK-mediated MLC phosphorylation.

  Journal of cellular physiology 20110201

• In vitro evaluation of IgE-mediated hypersensitivity reactions to quinolones.

  Allergy 20110201

• Cardioprotective effect of zinc requires ErbB2 and Akt during hypoxia/reoxygenation.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20110201

• Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.

  Toxicology in vitro : an international journal published in association with BIBRA 20110201

• Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors.

  International journal of radiation oncology, biology, physics 20110201

• Anti-apoptotic PI3K/Akt signaling by sodium/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia.

  Laboratory investigation; a journal of technical methods and pathology 20110201

• Time-resolved release of calcium from an epithelial cell monolayer during mucin secretion.

  European biophysics journal : EBJ 20110201

• Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

  Diabetes 20110201

• Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.

  British journal of pharmacology 20110201

• Hepatocyte growth factor and keratinocyte growth factor enhance IL-1-induced IL-8 secretion through different mechanisms in Caco-2 epithelial cells.

  In vitro cellular & developmental biology. Animal 20110201

• In vitro leptin treatment of rainbow trout hypothalamus and hindbrain affects glucosensing and gene expression of neuropeptides involved in food intake regulation.

  Peptides 20110201

• Chemotaxis of MDCK-F cells toward fibroblast growth factor-2 depends on transient receptor potential canonical channel 1.

  Pflugers Archiv : European journal of physiology 20110201

• Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt.

  International journal of molecular medicine 20110201

• Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.

  Endocrinology 20110201

• Integrin {alpha}3, but not {beta}1, regulates islet cell survival and function via PI3K/Akt signaling pathways.

  Endocrinology 20110201

• Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway.

  Stroke 20110201

• C3b-induced eosinophil degranulation involves PI3-kinases and is inhibited by protein kinase C activity.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20110201

• The role of β-adrenergic receptors in the cardioprotective effects of beta-preconditioning (βPC).

  Cardiovascular drugs and therapy 20110201

• Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes.

  Journal of cellular biochemistry 20110201

• Positive regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by mammalian target of rapamycin (mTOR) in RINm5F cells.

  Journal of cellular biochemistry 20110201

• The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism.

  The Plant cell 20110201

• PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.

  BMB reports 20110201

• Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis.

  PLoS pathogens 20110201

• Staphylococcus aureus α-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets.

  Toxins 20110201

• Ethanol extract of seeds of Oenothera odorata induces vasorelaxation via endothelium-dependent NO-cGMP signaling through activation of Akt-eNOS-sGC pathway.

  Journal of ethnopharmacology 20110127

• Genistein stimulates duodenal HCO(3)(-) secretion through PI3K pathway in mice.

  European journal of pharmacology 20110125

• Up-regulation of Ca(v)1.2 subunit via facilitating trafficking induced by Vps34 on morphine-induced place preference in mice.

  European journal of pharmacology 20110125

• Diabetogenic glucose and insulin concentrations modulate transcriptome and protein levels involved in tumour cell migration, adhesion and proliferation.

  British journal of cancer 20110118

• Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.

  Archives of biochemistry and biophysics 20110115

• Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening.

  Bioorganic & medicinal chemistry letters 20110115

• Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.

  Oncogene 20110113

• Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways.

  European journal of pharmacology 20110110

• PTEN inhibitors cause a negative inotropic and chronotropic effect in mice.

  European journal of pharmacology 20110110

• α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways.

  British journal of cancer 20110104

• Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling.

  British journal of cancer 20110104

• U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion.

  Life sciences 20110103

• 8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• 3,4-Di-O-Caffeoylquinic Acid Inhibits Angiotensin-II-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating the JNK and PI3K/Akt Signaling Pathways.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Inhibitors of phosphatidylinositol 3-kinase and mTOR but not Akt enhance replication of bovine ephemeral fever virus.

  Veterinary journal (London, England : 1997) 20110101

• Stimulation of retinoic acid-induced functional sodium iodide symporter (NIS) expression and cytotoxicity of ¹³¹I by carbamazepine in breast cancer cells.

  Breast cancer research and treatment 20110101

• SDF-1α inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways.

  Molecular biology reports 20110101

• Chorionic gonadotrophin regulates CXCR4 expression in human endometrium via E-series prostanoid receptor 2 signalling to PI3K-ERK1/2: implications for fetal-maternal crosstalk for embryo implantation.

  Molecular human reproduction 20110101

• Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells.

  Acta biomaterialia 20110101

• Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism.

  Cardiovascular research 20110101

• Human SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer PANC-1 cells.

  Pancreas 20110101

• Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo.

  Molecular pharmacology 20110101

• Sustained ligand-activated preconditioning via δ-opioid receptors.

  The Journal of pharmacology and experimental therapeutics 20110101

• Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.

  Diabetes 20110101

• Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110101

• Andrographolide-induced pi class of glutathione S-transferase gene expression via PI3K/Akt pathway in rat primary hepatocytes.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110101

• UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110101

• Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion.

  Basic research in cardiology 20110101

• Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

  Bioorganic & medicinal chemistry 20110101

• Akt-mediated mechanotransduction in murine fibroblasts during hypertrophic scar formation.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20110101

• Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats: activation of eNOS via the PI3K/Akt pathway.

  Journal of biomedicine & biotechnology 20110101

• Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value.

  International journal of Alzheimer's disease 20110101

• Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma.

  Journal of skin cancer 20110101

• Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways.

  Biological & pharmaceutical bulletin 20110101

• α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73.

  Breast cancer research : BCR 20110101

• Sorafenib inhibits the hepatocyte growth factor-mediated epithelial mesenchymal transition in hepatocellular carcinoma.

  Molecular cancer therapeutics 20110101

• Single-cell analysis of phosphoinositide 3-kinase and phosphatase and tensin homolog activation.

  Faraday discussions 20110101

• Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity.

  Journal of neuroinflammation 20110101

• Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway.

  Breast cancer research : BCR 20110101

• SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.

  Molecular vision 20110101

• Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma.

  PloS one 20110101

• Liposarcoma: molecular genetics and therapeutics.

  Sarcoma 20110101

• PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

  PloS one 20110101

• Nucleosome resection at a double-strand break during Non-Homologous Ends Joining in mammalian cells - implications from repressive chromatin organization and the role of ARTEMIS.

  BMC research notes 20110101

• Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms.

  Journal of signal transduction 20110101

• Antidepressants modulate intracellular amyloid peptide species in N2a neuroblastoma cells.

  Journal of Alzheimer's disease : JAD 20110101

• Dynamics of macrophage trogocytosis of rituximab-coated B cells.

  PloS one 20110101

• Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current.

  PloS one 20110101

• Effects of non-thermal plasma on mammalian cells.

  PloS one 20110101

• Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters.

  BMC cancer 20110101

• Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.

  PloS one 20110101

• Sildenafil reduces insulin-resistance in human endothelial cells.

  PloS one 20110101

• BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance.

  Journal of hematology & oncology 20110101

• Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping.

  PloS one 20110101

• Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components.

  Chinese medicine 20110101

• Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression.

  BMC cancer 20110101

• Drosophila S2 cells are non-permissive for vaccinia virus DNA replication following entry via low pH-dependent endocytosis and early transcription.

  PloS one 20110101

• Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages.

  PloS one 20110101

• Tissue inhibitor of metalloproteinase-1 counteracts glucolipotoxicity in the pancreatic β-cell line INS-1.

  Chinese medical journal 20110101

• Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants.

  PloS one 20110101

• Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.

  PloS one 20110101

• Metabolic syndrome, chronic kidney, and cardiovascular diseases: role of adipokines.

  Cardiology research and practice 20110101

• Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas.

  PloS one 20110101

• The Burkholderia pseudomallei type III secretion system and BopA are required for evasion of LC3-associated phagocytosis.

  PloS one 20110101

• Upregulation of AKT attenuates amyloid-β-induced cell apoptosis.

  Journal of Alzheimer's disease : JAD 20110101

• An integrative approach to identifying cancer chemoresistance-associated pathways.

  BMC medical genomics 20110101

• Alternative splicing and nonsense-mediated RNA decay contribute to the regulation of SHOX expression.

  PloS one 20110101

• Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells.

  Molecular medicine reports 20110101

• An invertebrate hyperglycemic model for the identification of anti-diabetic drugs.

  PloS one 20110101

• PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast.

  Journal of lipids 20110101

• Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer.

  Journal of translational medicine 20110101

• Staphylococcus aureus keratinocyte invasion is dependent upon multiple high-affinity fibronectin-binding repeats within FnBPA.

  PloS one 20110101

• IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition.

  Cell communication and signaling : CCS 20110101

• CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion.

  World journal of surgical oncology 20110101

• Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.

  Journal of oncology 20110101

• Tumor necrosis factor-α enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells.

  Journal of biomedical science 20110101

• Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis.

  PloS one 20110101

• Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer.

  PloS one 20110101

• Anti-bacterial effects of poly-N-acetyl-glucosamine nanofibers in cutaneous wound healing: requirement for Akt1.

  PloS one 20110101

• Aggregatibacter actinomycetemcomitans Omp29 is associated with bacterial entry to gingival epithelial cells by F-actin rearrangement.

  PloS one 20110101

• Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits.

  Journal of translational medicine 20110101

• The biomedical discourse relation bank.

  BMC bioinformatics 20110101

• LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cells.

  Cell communication and signaling : CCS 20110101

• Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein.

  Molecular cancer 20110101

• Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy.

  PloS one 20110101

• Targeting the DNA double strand break repair machinery in prostate cancer.

  PloS one 20110101

• Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy.

  BMC biology 20110101

• Integrin signaling in oligodendrocytes and its importance in CNS myelination.

  Journal of signal transduction 20110101

• Transport processes of radiopharmaceuticals and -modulators.

  Radiation oncology (London, England) 20110101

• Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest.

  PloS one 20110101

• Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum.

  PloS one 20110101

• Mechanisms of cellular uptake of cell-penetrating peptides.

  Journal of biophysics (Hindawi Publishing Corporation : Online) 20110101

• Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.

  PloS one 20110101

• Identification of genes regulating gene targeting by a high-throughput screening approach.

  Journal of nucleic acids 20110101

• Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.

  PloS one 20110101

• Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer.

  PloS one 20110101

• Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract.

  PloS one 20110101

• Control of host cell phosphorylation by legionella pneumophila.

  Frontiers in microbiology 20110101

• The mechanosensory role of primary cilia in vascular hypertension.

  International journal of vascular medicine 20110101

• Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway.

  International journal of biological sciences 20110101

• Role of SNX16 in the dynamics of tubulo-cisternal membrane domains of late endosomes.

  PloS one 20110101

• Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.

  PloS one 20110101

• β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins.

  Journal of signal transduction 20110101

• Modeling signal transduction in classical conditioning with network motifs.

  Frontiers in molecular neuroscience 20110101

• Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive.

  PloS one 20110101

• Caspase-3, myogenic transcription factors and cell cycle inhibitors are regulated by leukemia inhibitory factor to mediate inhibition of myogenic differentiation.

  Skeletal muscle 20110101

• Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.

  BMC immunology 20110101

• Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway.

  Journal of biomedical science 20110101

• The Role of BDNF/TrkB Signaling in Acute Amphetamine-Induced Locomotor Activity and Opioid Peptide Gene Expression in the Rat Dorsal Striatum.

  Frontiers in systems neuroscience 20110101

• 17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.

  PloS one 20110101

• Expression and functional roles of angiopoietin-2 in skeletal muscles.

  PloS one 20110101

• Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity.

  PloS one 20110101

• CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.

  PloS one 20110101

• Anchors for effectors: subversion of phosphoinositide lipids by legionella.

  Frontiers in microbiology 20110101

• Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer.

  Journal of translational medicine 20110101

• Transcriptional regulation by nonclassical action of thyroid hormone.

  Thyroid research 20110101

• SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition.

  PloS one 20110101

• Prevention of the wortmannin-induced inhibition of phosphoinositide 3-kinase by sulfhydryl reducing agents.

  Pharmacological reports : PR 20110101

• Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells.

  Journal of neuroinflammation 20110101

• Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.

  Enzyme research 20110101

• Fibrinolytic activation promoted by the cyclopentapeptide malformin: involvement of cytoskeletal reorganization.

  Biological & pharmaceutical bulletin 20110101

• Critical role of PI3K/Akt/GSK3β in motoneuron specification from human neural stem cells in response to FGF2 and EGF.

  PloS one 20110101

• Conversion of commensal Escherichia coli K-12 to an invasive form via expression of a mutant histone-like protein.

  mBio 20110101

• Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet.

  Nutrition & metabolism 20110101

• Serratia marcescens is able to survive and proliferate in autophagic-like vacuoles inside non-phagocytic cells.

  PloS one 20110101

• Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.

  PloS one 20110101

• Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells.

  PloS one 20110101

• Ghrelin o-acyl transferase: bridging ghrelin and energy homeostasis.

  International journal of peptides 20110101

• Proteopedia entry: phosphoinositide 3-kinase.

  Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 20110101

• Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation.

  PloS one 20110101

• Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo.

  BMC biology 20110101

• Erk1 positively regulates osteoclast differentiation and bone resorptive activity.

  PloS one 20110101

• Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.

  BMC cancer 20110101

• Formulation of diblock polymeric nanoparticles through nanoprecipitation technique.

  Journal of visualized experiments : JoVE 20110101

• Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.

  PloS one 20110101

• A regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the control of cell proliferation.

  PloS one 20110101

• Mechanism of cellular uptake and impact of ferucarbotran on macrophage physiology.

  PloS one 20110101

• Neuroprotective actions of ghrelin and growth hormone secretagogues.

  Frontiers in molecular neuroscience 20110101

• Coordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability.

  PloS one 20110101

• Atg14: a key player in orchestrating autophagy.

  International journal of cell biology 20110101

• Cucurbitacins-type triterpene with potent activity on mouse embryonic fibroblast from Cucumis prophetarum, cucurbitaceae.

  Pharmacognosy research 20110101

• Mechanism of salutary effects of astringinin on rodent hepatic injury following trauma-hemorrhage: Akt-dependent hemeoxygenase-1 signaling pathways.

  PloS one 20110101

• Arabidopsis R-SNARE proteins VAMP721 and VAMP722 are required for cell plate formation.

  PloS one 20110101

• Magnetic resonance spectroscopy detectable metabolomic fingerprint of response to antineoplastic treatment.

  PloS one 20110101

• Curcumin attenuates insulin resistance in hepatocytes by inducing Nrf2 nuclear translocation.

  Hepato-gastroenterology 20110101

• The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages.

  PloS one 20110101

• GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells.

  PloS one 20110101

• Ischemic postconditioning attenuates liver warm ischemia-reperfusion injury through Akt-eNOS-NO-HIF pathway.

  Journal of biomedical science 20110101

• Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages.

  PloS one 20110101

• Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr.

  Radiation oncology (London, England) 20110101

• Inductive specification and axonal orientation of spinal neurons mediated by divergent bone morphogenetic protein signaling pathways.

  Neural development 20110101

• Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.

  Molecular biology international 20110101

• Innovative Therapies against Human Glioblastoma Multiforme.

  ISRN oncology 20110101

• Insulin augments tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells.

  Journal of inflammation (London, England) 20110101

• Autophagy in human embryonic stem cells.

  PloS one 20110101

• S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer.

  PloS one 20110101

• Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.

  Molecular cancer 20110101

• Modeling the basal dynamics of p53 system.

  PloS one 20110101

• Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.

  PloS one 20110101

• Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy.

  Journal of ophthalmology 20110101

• Golgi apparatus-localized synaptotagmin 2 is required for unconventional secretion in Arabidopsis.

  PloS one 20110101

• NADPH oxidase-2 derived ROS dictates murine DC cytokine-mediated cell fate decisions during CD4 T helper-cell commitment.

  PloS one 20110101

• Phosphorylation of AIB1 at mitosis is regulated by CDK1/CYCLIN B.

  PloS one 20110101

• Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles.

  Journal of carcinogenesis 20110101

• IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.

  PloS one 20110101

• Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat.

  PloS one 20110101

• Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.

  PloS one 20110101

• Spatial regulation of exocytic site and vesicle mobilization by the actin cytoskeleton.

  PloS one 20110101

• LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.

  PloS one 20110101

• The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.

  Cell communication and signaling : CCS 20110101

• The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase.

  PloS one 20110101

• Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells.

  PloS one 20110101

• [Activation of the phosphatidylinositol-3'-kinase pathway with lectin-induced signal through sialo-containing glycoproteins of leukocyte membranes under type 1 diabetes mellitus].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20110101

• Signal protein-derived peptides as functional probes and regulators of intracellular signaling.

  Journal of amino acids 20110101

• Role of Charged Residues in the Catalytic Sites of Escherichia coli ATP Synthase.

  Journal of amino acids 20110101

• Grand challenge: viewing transporter function in a pointillist landscape.

  Frontiers in plant science 20110101

• Membrane traffic and fusion at post-Golgi compartments.

  Frontiers in plant science 20110101

• PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction.

  Frontiers in endocrinology 20110101

• Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages.

  The Journal of biological chemistry 20101217

• Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling.

  The Biochemical journal 20101215

• Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.

  Journal of immunology (Baltimore, Md. : 1950) 20101215

• Corticosterone decreases the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes.

  Steroids 20101212

• CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.

  The Journal of biological chemistry 20101210

• Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells.

  Experimental cell research 20101210

• Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.

  Journal of proteome research 20101203

• Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20101201

• Neuregulin-1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes.

  Cardiovascular research 20101201

• Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.

  Biochimie 20101201

• Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• Cardioprotective PKG-independent NO signaling at reperfusion.

  American journal of physiology. Heart and circulatory physiology 20101201

• PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1).

  Journal of molecular medicine (Berlin, Germany) 20101201

• Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells.

  Neuropeptides 20101201

• Erythropoietin enhances hydrogen peroxide-mediated dilatation of canine coronary collateral arterioles during myocardial ischemia in dogs in vivo.

  American journal of physiology. Heart and circulatory physiology 20101201

• Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy.

  Diabetologia 20101201

• The Sir Hans Krebs Lecture. How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden.

  The FEBS journal 20101201

• MDM2-related responses in 3T3-L1 adipocytes exposed to cooling and subsequent rewarming.

  Cryobiology 20101201

• Activation of phosphatidylinositol 3-kinase/Akt and impairment of nuclear factor-kappaB: molecular mechanisms behind the arrested maturation/activation state of Leishmania infantum-infected dendritic cells.

  The American journal of pathology 20101201

• Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation.

  Oncology reports 20101201

• Phosphoinositide 3-kinase induced activation and cytoskeletal translocation of protein kinase CK2 in protease activated receptor 1-stimulated platelets.

  Thrombosis research 20101201

• Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.

  Cancer research 20101201

• Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes.

  Acta pharmacologica Sinica 20101201

• Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster.

  PLoS genetics 20101201

• Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling.

  PLoS pathogens 20101201

• Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis.

  Cell death & disease 20101201

• Involvement of Src family tyrosine kinase in apoptosis of human neutrophils induced by protozoan parasite Entamoeba histolytica.

  The Korean journal of parasitology 20101201

• Mechanisms and prospects of ischemic tolerance induced by cerebral preconditioning.

  International neurourology journal 20101201

• Demonstration of a visual cell-based assay for screening glucose transporter 4 translocation modulators in real time.

  Journal of biosciences 20101201

• Increased levels of p53 and PARP-1 in EL-4 cells probably related with the immune adaptive response induced by low dose ionizing radiation in vitro.

  Biomedical and environmental sciences : BES 20101201

• Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

  Cell death & disease 20101201

• [Effect of laminar shear stress on the expression of matrix metalloproteinases-9 in rat bone marrow-derived mesenchymal stem cells].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20101201

• Jaagsiekte sheep retrovirus biology and oncogenesis.

  Viruses 20101201

• Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA₁₋₆₄) in the rat heart.

  Regulatory peptides 20101130

• Activation of phosphatidylinositol 3-kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered rilmenidine.

  European journal of pharmacology 20101125

• STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.

  Immunity 20101124

• Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis.

  The EMBO journal 20101117

• Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs.

  Journal of medicinal chemistry 20101111

• NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.

  The Journal of biological chemistry 20101105

• CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide.

  International journal of cancer 20101101

• Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways.

  Journal of cellular physiology 20101101

• Dependence of resolvin-induced increases in corneal epithelial cell migration on EGF receptor transactivation.

  Investigative ophthalmology & visual science 20101101

• Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase.

  Journal of molecular and cellular cardiology 20101101

• Vasoactive intestinal polypeptide relaxes isolated rat pulmonary artery rings through two distinct mechanisms.

  The journal of physiological sciences : JPS 20101101

• Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.

  Experimental hematology 20101101

• Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signaling pathway in ovarian clear cell carcinoma cells.

  Gynecologic oncology 20101101

• Different effects of erythropoietin in cisplatin- and docetaxel-induced neurotoxicity: an in vitro study.

  Journal of neuroscience research 20101101

• Insulin reciprocally regulates glucagon secretion in humans.

  Diabetes 20101101

• Phosphoinositide 3-kinase-dependent regulation of Na+/H+ exchanger in dendritic cells.

  Pflugers Archiv : European journal of physiology 20101101

• Ethylene suppression of sugar-induced anthocyanin pigmentation in Arabidopsis.

  Plant physiology 20101101

• Replication-dependent γ-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells.

  Oncology reports 20101101

• Enhanced Ca2+-dependent activation of phosphoinositide 3-kinase class IIα isoform-Rho axis in blood vessels of spontaneously hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20101101

• Rimonabant inhibits TNF-α-induced endothelial IL-6 secretion via CB1 receptor and cAMP-dependent protein kinase pathway.

  Acta pharmacologica Sinica 20101101

• 17beta-estradiol augments 18F-FDG uptake and glycolysis of T47D breast cancer cells via membrane-initiated rapid PI3K-Akt activation.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20101101

• Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs.

  Oncotarget 20101101

• Tea catechins modulate the glucose transport system in 3T3-L1 adipocytes.

  Food & function 20101101

• IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species.

  Experimental & molecular medicine 20101031

• Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion.

  The Journal of biological chemistry 20101029

• Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1α in MSCs.

  Biochemical and biophysical research communications 20101029

• Vascular relaxation by ethanol extract of Xanthoceras sorbifolia via Akt- and SOCE-eNOS-cGMP pathways.

  Journal of ethnopharmacology 20101028

• Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors.

  The Journal of biological chemistry 20101022

• Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathway.

  Brain research 20101021

• Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.

  Toxicology and applied pharmacology 20101015

• Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.

  Journal of medicinal chemistry 20101014

• Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.

  Blood 20101007

• Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection.

  Journal of cellular and molecular medicine 20101001

• Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20101001

• Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway.

  Cancer letters 20101001

• Opposite expression of securin and γ-H2AX regulates baicalein-induced cancer cell death.

  Journal of cellular biochemistry 20101001

• Downregulation of manganese superoxide dismutase by angiotensin II in cardiac fibroblasts of rats: Association with oxidative stress in myocardium.

  American journal of hypertension 20101001

• p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

  Cellular signalling 20101001

• Postprocedure administration of insulin in canine autologous vein grafting: a potential strategy to attenuate intimal hyperplasia.

  Journal of cardiovascular pharmacology 20101001

• Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation.

  Journal of neuroscience research 20101001

• Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects against cerebral infarction: Involvement of the phosphatidylinositol-3 kinase/Akt pathway.

  Experimental neurology 20101001

• Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels.

  American journal of physiology. Heart and circulatory physiology 20101001

• Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C.

  Hepatology (Baltimore, Md.) 20101001

• Myofibroblasts protect myoblasts from intrinsic apoptosis associated with differentiation via β1 integrin-PI3K/Akt pathway.

  Development, growth & differentiation 20101001

• Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption.

  British journal of pharmacology 20101001

• The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation.

  British journal of pharmacology 20101001

• Effect of ghrelin on angiotensin II induced human umbilicus vein endothelial cell oxidative stress and endothelial cell injury.

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20101001

• ICAM-1 cytoplasmic tail regulates endothelial glutathione synthesis through a NOX4/PI3-kinase-dependent pathway.

  Free radical biology & medicine 20100915

• Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.

  The EMBO journal 20100915

• Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway.

  European journal of pharmacology 20100910

• A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.

  The Journal of biological chemistry 20100903

• The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector.

  Cellular microbiology 20100901

• TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism.

  Cardiovascular research 20100901

• Na+/K+-ATPase inhibition by ouabain induces CaMKII-dependent apoptosis in adult rat cardiac myocytes.

  Journal of molecular and cellular cardiology 20100901

• PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells.

  Cellular signalling 20100901

• Nitric oxide synthesis is reduced in subjects with type 2 diabetes and nephropathy.

  Diabetes 20100901

• WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant.

  The Journal of pharmacology and experimental therapeutics 20100901

• Cellular depletion of atypical PKC{lambda} is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells.

  American journal of physiology. Endocrinology and metabolism 20100901

• Is leptin involved in phagocytic NADPH oxidase overactivity in obesity? Potential clinical implications.

  Journal of hypertension 20100901

• Homomeric interaction of AtVSR1 is essential for its function as a vacuolar sorting receptor.

  Plant physiology 20100901

• Sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins.

  Journal of Zhejiang University. Science. B 20100901

• Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells.

  Diabetes 20100901

• Interleukin-8 induction due to diffusely adherent Escherichia coli possessing Afa/Dr genes depends on flagella and epithelial Toll-like receptor 5.

  Microbiology and immunology 20100901

• Literature mining for the discovery of hidden connections between drugs, genes and diseases.

  PLoS computational biology 20100901

• Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner.

  PLoS pathogens 20100901

• [Chemotherapy resistance induced by interleukin-6 in ovarian cancer cells and its signal transduction pathways].

  Zhonghua fu chan ke za zhi 20100901

• PI3Kα inhibitors that inhibit metastasis.

  Oncotarget 20100901

• Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease.

  Current neuropharmacology 20100901

• Antiinflammatory activity of melatonin in central nervous system.

  Current neuropharmacology 20100901

• MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress.

  Biochemical and biophysical research communications 20100827

• Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair.

  The Journal of biological chemistry 20100820

• Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells.

  Progress in neuro-psychopharmacology & biological psychiatry 20100816

• Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins.

  Autophagy 20100816

• The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells.

  The Journal of biological chemistry 20100813

• Down-regulation of c-Met expression inhibits human HCC cells growth and invasion by RNA interference.

  The Journal of surgical research 20100801

• Role of growth factor receptor transactivation in high glucose-induced increased levels of Gq/11alpha and signaling in vascular smooth muscle cells.

  Journal of molecular and cellular cardiology 20100801

• Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation.

  Cancer letters 20100801

• Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.

  Journal of lipid research 20100801

• Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament.

  Biochimica et biophysica acta 20100801

• Characterization of the migration of lung and blood T cells in response CXCL12 in a three-dimensional matrix.

  Immunology 20100801

• EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes.

  Journal of cellular physiology 20100801

• Involvement of receptor tyrosine phosphatase DEP-1 mediated PI3K-cofilin signaling pathway in sorafenib-induced cytoskeletal rearrangement in hepatoma cells.

  Journal of cellular physiology 20100801

• Peptidoglycan enhances proinflammatory cytokine expression through the TLR2 receptor, MyD88, phosphatidylinositol 3-kinase/AKT and NF-kappaB pathways in BV-2 microglia.

  International immunopharmacology 20100801

• Insulin-like growth factor-1 induces phosphorylation of PI3K-Akt/PKB to potentiate proliferation of smooth muscle cells in human saphenous vein.

  Experimental and molecular pathology 20100801

• Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs.

  American journal of physiology. Heart and circulatory physiology 20100801

• Screening cellular feature measurements for image-based assay development.

  Journal of biomolecular screening 20100801

• Disruption of gap junctions attenuates aminoglycoside-elicited renal tubular cell injury.

  British journal of pharmacology 20100801

• Effect of pycnogenol on glucose transport in mature 3T3-L1 adipocytes.

  Phytotherapy research : PTR 20100801

• ERK 1/2 and PI-3 kinase pathways as a potential mechanism of ghrelin action on cell proliferation and apoptosis in the porcine ovarian follicular cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100801

• Rationale for targeting pepsin in the treatment of reflux disease.

  The Annals of otology, rhinology, and laryngology 20100801

• Mechanism of cardioprotective effect of erythropoietin-induced preconditioning in rat heart.

  Indian journal of pharmacology 20100801

• 17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

  Journal of immunology (Baltimore, Md. : 1950) 20100715

• The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain.

  The Journal of biological chemistry 20100702

• Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain.

  Acta anaesthesiologica Scandinavica 20100701

• Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

  Cellular microbiology 20100701

• Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage.

  Surgery 20100701

• GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.

  Journal of lipid research 20100701

• The role of mast cells in parathyroid bone disease.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100701

• The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism.

  Cellular signalling 20100701

• Antiangiogenic effects and transcriptional regulation of pigment epithelium-derived factor in diabetic retinopathy.

  Microvascular research 20100701

• Insulin and insulin-like growth factor I signaling pathways in rainbow trout (Oncorhynchus mykiss) during adipogenesis and their implication in glucose uptake.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100701

• LPLI inhibits apoptosis upstream of Bax translocation via a GSK-3beta-inactivation mechanism.

  Journal of cellular physiology 20100701

• Long-term protection and mechanism of pacing-induced postconditioning in the heart.

  Basic research in cardiology 20100701

• Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.

  Diabetologia 20100701

• Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers.

  American journal of physiology. Gastrointestinal and liver physiology 20100701

• An integrated imaging approach to the study of oxidative stress generation by mitochondrial dysfunction in living cells.

  Environmental health perspectives 20100701

• Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation.

  Endocrinology 20100701

• Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor.

  Endocrinology 20100701

• Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway.

  Stroke 20100701

• The Akt-endothelial nitric oxide synthase pathway in lipopolysaccharide preconditioning-induced hypoxic-ischemic tolerance in the neonatal rat brain.

  Stroke 20100701

• Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells.

  Oncology reports 20100701

• Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation.

  Acta pharmacologica Sinica 20100701

• Thrombin stimulates RPE cell motility by PKC-zeta- and NF-kappaB-dependent gene expression of MCP-1 and CINC-1/GRO chemokines.

  Journal of cellular biochemistry 20100701

• Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vessels.

  British journal of pharmacology 20100701

• HIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway.

  PLoS pathogens 20100701

• FgTep1p is linked to the phosphatidylinositol-3 kinase signalling pathway and plays a role in the virulence of Fusarium graminearum on wheat.

  Molecular plant pathology 20100701

• The chemical constituents of endophytic fungus Trichoderma sp. MFF-1.

  Chemistry & biodiversity 20100701

• Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement.

  British journal of cancer 20100629

• Characterization of the cell-penetrating properties of the Epstein-Barr virus ZEBRA trans-activator.

  The Journal of biological chemistry 20100625

• MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand.

  The Journal of biological chemistry 20100625

• Probing the probes: fitness factors for small molecule tools.

  Chemistry & biology 20100625

• Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes.

  Clinical science (London, England : 1979) 20100622

• Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis.

  Blood 20100617

• Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells.

  Toxicon : official journal of the International Society on Toxinology 20100615

• Selective blockade of protein kinase B protects the rat and human myocardium against ischaemic injury.

  The Journal of physiology 20100615

• Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females.

  Circulation research 20100611

• Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.

  Life sciences 20100605

• Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells.

  FEBS letters 20100603

• BCR/ABL downregulates DNA-PK(CS)-dependent and upregulates backup non-homologous end joining in leukemic cells.

  Molecular biology reports 20100601

• Role of dephosphorylation of FOXO1 on apoptosis induced by wortmannin for non-Hodgkin's lymphoma cells.

  Molecular biology reports 20100601

• Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior.

  Physiology & behavior 20100601

• Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line.

  Pathology oncology research : POR 20100601

• Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3beta, and apoptosis.

  Molecular and cellular biochemistry 20100601

• Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100601

• Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.

  Cellular signalling 20100601

• Membrane-impermeable estrogen is involved in regulation of calbindin-D9k expression via non-genomic pathways in a rat pituitary cell line, GH3 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

  Biochemical pharmacology 20100601

• Simulated microgravity perturbs actin polymerization to promote nitric oxide-associated migration in human immortalized Eahy926 cells.

  Protoplasma 20100601

• Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Platelet tissue factor synthesis in type 2 diabetic patients is resistant to inhibition by insulin.

  Diabetes 20100601

• JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20100601

• PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.

  Experimental eye research 20100601

• Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus.

  Journal of neuroendocrinology 20100601

• TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.

  Diabetes 20100601

• Effect of pressure overload on cardioprotection via PI3K-Akt: comparison of postconditioning, insulin, and pressure unloading.

  American journal of hypertension 20100601

• EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway.

  Molecular pharmacology 20100601

• A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts.

  Journal of periodontal research 20100601

• Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinase.

  Endocrinology 20100601

• Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits.

  Journal of cardiovascular pharmacology 20100601

• Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit.

  Journal of neurochemistry 20100601

• Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro.

  Hypertension (Dallas, Tex. : 1979) 20100601

• Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation.

  American journal of physiology. Cell physiology 20100601

• The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.

  EMBO reports 20100601

• Role of ERK1/2 in platelet lysate-driven endothelial cell repair.

  Journal of cellular biochemistry 20100601

• BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro.

  Molecular cancer therapeutics 20100601

• Ginsenoside Rb1 protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening.

  Acta pharmacologica Sinica 20100601

• A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.

  PLoS pathogens 20100601

• Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA.

  PLoS pathogens 20100601

• The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.

  Oncotarget 20100601

• Water extract of Zanthoxylum piperitum induces vascular relaxation via endothelium-dependent NO-cGMP signaling.

  Journal of ethnopharmacology 20100527

• Protein kinase C inhibits autophagy and phosphorylates LC3.

  Biochemical and biophysical research communications 20100514

• The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.

  Brain research 20100512

• FAK activation is required for TNF-alpha-induced IL-6 production in myoblasts.

  Journal of cellular physiology 20100501

• Aerobic exercise acutely improves insulin- and insulin-like growth factor-1-mediated vasorelaxation in hypertensive rats.

  Experimental physiology 20100501

• Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia.

  American journal of physiology. Heart and circulatory physiology 20100501

• Lysimachia clethroides extract promote vascular relaxation via endothelium-dependent mechanism.

  Journal of cardiovascular pharmacology 20100501

• Phosphatidylinositol 3-kinase mediates pain behaviors induced by activation of peripheral ephrinBs/EphBs signaling in mice.

  Pharmacology, biochemistry, and behavior 20100501

• Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation.

  Arteriosclerosis, thrombosis, and vascular biology 20100501

• Cyclic AMP stimulates Mrp2 translocation by activating p38{alpha} MAPK in hepatic cells.

  American journal of physiology. Gastrointestinal and liver physiology 20100501

• Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis.

  American journal of physiology. Gastrointestinal and liver physiology 20100501

• Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes.

  The Journal of physiology 20100501

• Vasostatin 1 activates eNOS in endothelial cells through a proteoglycan-dependent mechanism.

  Journal of cellular biochemistry 20100501

• Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein.

  Molecular nutrition & food research 20100501

• Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation.

  International journal of oncology 20100501

• Bradykinin-induced cell migration and COX-2 production mediated by the bradykinin B1 receptor in glioma cells.

  Journal of cellular biochemistry 20100501

• Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.

  The FEBS journal 20100501

• Ouabain attenuates cardiotoxicity induced by other cardiac steroids.

  British journal of pharmacology 20100501

• Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation.

  PLoS pathogens 20100501

• Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications.

  Current genomics 20100501

• Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.

  Journal of neuroimmunology 20100415

• Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.

  The Journal of biological chemistry 20100402

• Partitioning of casein kinase 1-like 6 to late endosome-like vesicles.

  Protoplasma 20100401

• Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway.

  Cardiovascular research 20100401

• Leukemia inhibitory factor-dependent increase in myoblast cell number is associated with phosphotidylinositol 3-kinase-mediated inhibition of apoptosis and not mitosis.

  Experimental cell research 20100401

• Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition.

  Toxicology in vitro : an international journal published in association with BIBRA 20100401

• Extracellular ubiquitin inhibits beta-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3beta and mitochondrial pathways.

  Cardiovascular research 20100401

• Angiotensin II regulates endothelial cell migration through calcium influx via T-type calcium channel in human umbilical vein endothelial cells.

  Acta physiologica (Oxford, England) 20100401

• T-cadherin modulates endothelial barrier function.

  Journal of cellular physiology 20100401

• 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.

  American journal of physiology. Lung cellular and molecular physiology 20100401

• Agonist monoclonal antibodies against HGF receptor protect cardiac muscle cells from apoptosis.

  American journal of physiology. Heart and circulatory physiology 20100401

• Obesity and pancreatic cancer: possible role of the PI3K/Akt pathway.

  Surgery 20100401

• Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress.

  American journal of physiology. Endocrinology and metabolism 20100401

• Encystation process of Giardia lamblia: morphological and regulatory aspects.

  Archives of microbiology 20100401

• Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia.

  Autophagy 20100401

• Interdependence of endomembrane trafficking and actin dynamics during polarized growth of Arabidopsis pollen tubes.

  Plant physiology 20100401

• Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR.

  Molecular oncology 20100401

• Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.

  Journal of immunology (Baltimore, Md. : 1950) 20100401

• Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway.

  Endocrinology 20100401

• Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation.

  International journal of oncology 20100401

• Involvement of Akt in synergistic effects of thermo-chemotherapy on human small cell lung cancer H446 cell apoptosis.

  Chinese journal of cancer 20100401

• Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.

  Diabetes, obesity & metabolism 20100401

• Analysis of FcgammaRIIA cytoplasmic tail requirements in signaling for serotonin secretion: evidence for an ITAM-dependent, PI3K-dependent pathway.

  Scandinavian journal of immunology 20100401

• A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells.

  PLoS pathogens 20100401

• Protective effect of autophagy in laser-induced glioma cell death in vitro.

  Lasers in surgery and medicine 20100401

• Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells.

  Journal of periodontal research 20100401

• Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.

  The Journal of biological chemistry 20100326

• PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking.

  Blood 20100325

• [Expression and significance of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway in severe acute pancreatitis-associated lung injury].

  Zhonghua yi xue za zhi 20100323

• Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling.

  Antioxidants & redox signaling 20100315

• SHIP is required for dendritic cell maturation.

  Journal of immunology (Baltimore, Md. : 1950) 20100315

• Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

  Cancer research 20100315

• Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation.

  The Journal of biological chemistry 20100305

• Chrysanthemum morifolium Ramat. reduces the oxidized LDL-induced expression of intercellular adhesion molecule-1 and E-selectin in human umbilical vein endothelial cells.

  Journal of ethnopharmacology 20100302

• Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways.

  Haematologica 20100301

• Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition.

  Basic research in cardiology 20100301

• Hyaluronan oligosaccharide treatment of chondrocytes stimulates expression of both HAS-2 and MMP-3, but by different signaling pathways.

  Osteoarthritis and cartilage 20100301

• Autophagy is involved in starvation response and cell death in Blastocystis.

  Microbiology (Reading, England) 20100301

• Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors.

  The Journal of pharmacology and experimental therapeutics 20100301

• Akt downregulation by flavin oxidase-induced ROS generation mediates dose-dependent endothelial cell damage elicited by natural antioxidants.

  Toxicological sciences : an official journal of the Society of Toxicology 20100301

• Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells.

  Carcinogenesis 20100301

• Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia.

  Journal of neurochemistry 20100301

• Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100301

• High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.

  American journal of physiology. Heart and circulatory physiology 20100301

• B-type natriuretic peptide protects cardiomyocytes at reperfusion via mitochondrial calcium uniporter.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100301

• Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts.

  European journal of heart failure 20100301

• Protection from rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling.

  Cancer research 20100301

• CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway.

  BMB reports 20100301

• Influence of ischemia/reperfusion and modulation of PI3K/Akt kinase pathway on matrix metalloproteinase-2 in rat hearts.

  General physiology and biophysics 20100301

• [PI3-kinase mediates thrombin-induced platelet aggregation through mDia1 pathway.].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20100301

• Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax.

  European journal of pharmacology 20100225

• Dissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt.

  The Journal of biological chemistry 20100219

• 2-(3,4-Dihydro-2H-pyrrolium-1-yl)-3oxoindan-1-olate (DHPO), a novel, synthetic small molecule that alleviates insulin resistance and lipid abnormalities.

  Biochemical pharmacology 20100215

• Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia.

  The Journal of physiology 20100215

• Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.

  The Journal of biological chemistry 20100212

• Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle.

  Molecular and cellular endocrinology 20100205

• Stoichiometric quantification of Akt phosphorylation using LC-MS/MS.

  Journal of proteome research 20100205

• Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells.

  FEBS letters 20100205

• Genomic and non-genomic actions of estrogen on synaptic plasticity in SH-SY5Y cells.

  Neuroscience letters 20100205

• Rosiglitazone-induced myocardial protection against ischaemia-reperfusion injury is mediated via a phosphatidylinositol 3-kinase/Akt-dependent pathway.

  Clinical and experimental pharmacology & physiology 20100201

• Inhibition of autophagy induced by overexpression of mda-7/interleukin-24 strongly augments the antileukemia activity in vitro and in vivo.

  Cancer gene therapy 20100201

• Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species.

  Free radical research 20100201

• Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.

  Journal of cellular physiology 20100201

• Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

  American journal of physiology. Cell physiology 20100201

• Effects of insulin-like growth factor-I, insulin, and leucine on protein turnover and ubiquitin ligase expression in rainbow trout primary myocytes.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100201

• Oxytocin increases glucose uptake in neonatal rat cardiomyocytes.

  Endocrinology 20100201

• Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK.

  Prostaglandins & other lipid mediators 20100201

• Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment.

  Autophagy 20100201

• Incretin concepts.

  Diabetes care 20100201

• Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells.

  Autophagy 20100201

• Stem cell therapy: pieces of the puzzle.

  Journal of cardiovascular translational research 20100201

• Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells.

  British journal of pharmacology 20100201

• Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.

  PLoS pathogens 20100201

• Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion.

  PLoS computational biology 20100201

• ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9.

  Archives of pharmacal research 20100201

• Leptin and the Regulation of Renal Sodium Handling and Renal Na-Transporting ATPases: Role in the Pathogenesis of Arterial Hypertension.

  Current cardiology reviews 20100201

• Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning.

  Cell death & disease 20100201

• Resolvin E1 receptor activation signals phosphorylation and phagocytosis.

  The Journal of biological chemistry 20100129

• Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis.

  The Biochemical journal 20100127

• Leptin excites proopiomelanocortin neurons via activation of TRPC channels.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100127

• Cell context-dependent involvement of ATR in early stages of retroviral replication.

  Virology 20100120

• Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes.

  The Journal of biological chemistry 20100115

• Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates.

  Journal of medicinal chemistry 20100114

• [Effect of anti-cancer drugs on the expression of BIC/miR-155 in human pancreatic cancer PANC-1 cells].

  Zhonghua yi xue za zhi 20100112

• Revised role of glycosaminoglycans in TAT protein transduction domain-mediated cellular transduction.

  The Journal of biological chemistry 20100108

• Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.

  The Journal of biological chemistry 20100108

• The suppressive effect of Rho kinase inhibitor, Y-27632, on oncogenic Ras/RhoA induced invasion/migration of human bladder cancer TSGH cells.

  Chemico-biological interactions 20100105

• Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy.

  British journal of cancer 20100105

• A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.

  British journal of cancer 20100105

• High glucose attenuates insulin-induced VEGF expression in bovine retinal microvascular endothelial cells.

  Eye (London, England) 20100101

• Role of phosphatidylinositol-3-kinase (PI3K), extracellular signal-regulated kinase (ERK) and nuclear transcription factor kappa beta (NF-k beta) on neutrophil phagocytic process of Candida albicans.

  Molecular and cellular biochemistry 20100101

• Attenuation of infarction in cynomolgus monkeys: preconditioning and postconditioning.

  Basic research in cardiology 20100101

• Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes.

  Muscle & nerve 20100101

• The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin.

  Pharmacology, biochemistry, and behavior 20100101

• High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.

  Diabetes 20100101

• Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury.

  Journal of cardiovascular pharmacology 20100101

• Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry.

  The Biochemical journal 20100101

• Chronic hyperleptinemia induces resistance to acute natriuretic and NO-mimetic effects of leptin.

  Peptides 20100101

• Angiogenic activity of sesamin through the activation of multiple signal pathways.

  Biochemical and biophysical research communications 20100101

• PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions.

  Channels (Austin, Tex.) 20100101

• Hypoxia switches glucose depletion-induced necrosis to phosphoinositide 3-kinase/Akt-dependent apoptosis in A549 lung adenocarcinoma cells.

  International journal of oncology 20100101

• A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart.

  Glycobiology 20100101

• Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.

  Rejuvenation research 20100101

• Plasma membrane trafficking in alveolar type II cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70.

  PloS one 20100101

• F-Prostaglandin receptor regulates endothelial cell function via fibroblast growth factor-2.

  BMC cell biology 20100101

• Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida.

  Reproductive biology and endocrinology : RB&E 20100101

• DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development.

  PloS one 20100101

• Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages.

  PloS one 20100101

• Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma.

  Molecular cancer 20100101

• Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.

  PloS one 20100101

• Ceramide and ceramide 1-phosphate in health and disease.

  Lipids in health and disease 20100101

• Neurofilament heavy polypeptide regulates the Akt-beta-catenin pathway in human esophageal squamous cell carcinoma.

  PloS one 20100101

• Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro.

  BMC neuroscience 20100101

• Signaling pathways involved in LPS induced TNFalpha production in human adipocytes.

  Journal of inflammation (London, England) 20100101

• Cellular processes of v-Src transformation revealed by gene profiling of primary cells--implications for human cancer.

  BMC cancer 20100101

• Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae.

  PloS one 20100101

• AMPK exerts dual regulatory effects on the PI3K pathway.

  Journal of molecular signaling 20100101

• Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles.

  Veterinary research 20100101

• Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8.

  BMC cancer 20100101

• Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.

  PloS one 20100101

• Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils.

  Journal of inflammation (London, England) 20100101

• Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.

  PloS one 20100101

• Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage.

  Arthritis research & therapy 20100101

• Sodium nitroprusside induces autophagic cell death in glutathione-depleted osteoblasts.

  Journal of biochemical and molecular toxicology 20100101

• DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.

  BMC molecular biology 20100101

• Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines.

  Journal of oncology 20100101

• The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation.

  Disease models & mechanisms 20100101

• Overstressed mechanical stretching activates survival and apoptotic signals in fibroblasts.

  Cells, tissues, organs 20100101

• Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium.

  BMC research notes 20100101

• Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts.

  Breast cancer research : BCR 20100101

• PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells.

  Molecular cancer 20100101

• Polarization of migrating monocytic cells is independent of PI 3-kinase activity.

  PloS one 20100101

• [The roles of PI3K/Akt pathway in proliferation of Schwann cells promoted by pyrroloquinoline quinone].

  Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20100101

• [The effect of angiotensin II on phosphoinositide-3 kinase/Akt cascade in cultured fibroblasts derived from patients with hypertrophic scars].

  Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20100101

• Pathogenesis of insulin resistance in skeletal muscle.

  Journal of biomedicine & biotechnology 20100101

• Radiation-induced XRCC4 association with chromatin DNA analyzed by biochemical fractionation.

  Journal of radiation research 20100101

• Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1-mediated ICAM-1 expression in breast cancer cells.

  Molecular cancer 20100101

• Regulatory effect of cinnamaldehyde on monocyte/macrophage-mediated inflammatory responses.

  Mediators of inflammation 20100101

• Small molecule inhibitors of the PI3-kinase family.

  Current topics in microbiology and immunology 20100101

• Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice.

  Arthritis research & therapy 20100101

• Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells.

  BMC cell biology 20100101

• PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis.

  International archives of allergy and immunology 20100101

• Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis.

  PloS one 20100101

• The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability.

  Molecular cancer 20100101

• [The involvement of tyrosine kinases and phosphatidylinositol kinases in the effect of oxidized glutathione and glutoxim on Na+ transport in frog skin].

  Tsitologiia 20100101

• Progesterone reverses the mesenchymal phenotypes of basal phenotype breast cancer cells via a membrane progesterone receptor mediated pathway.

  Breast cancer research : BCR 20100101

• Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations.

  BMC cancer 20100101

• New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).

  Current topics in microbiology and immunology 20100101

• Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon.

  PloS one 20100101

• CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion.

  Journal of ovarian research 20100101

• Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.

  Breast cancer research : BCR 20100101

• Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation.

  BMC cell biology 20100101

• An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival.

  BMC cell biology 20100101

• Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.

  PloS one 20100101

• Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation.

  PloS one 20100101

• Ghrelin modulates insulin sensitivity and tau phosphorylation in high glucose-induced hippocampal neurons.

  Biological & pharmaceutical bulletin 20100101

• Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1.

  Journal of experimental & clinical cancer research : CR 20100101

• Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes.

  PloS one 20100101

• Glycogen Synthase Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric cancer cells.

  Journal of molecular signaling 20100101

• Bacillus anthracis spore entry into epithelial cells is an actin-dependent process requiring c-Src and PI3K.

  PloS one 20100101

• Mesenchymal migration as a therapeutic target in glioblastoma.

  Journal of oncology 20100101

• DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism.

  PloS one 20100101

• Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization.

  Molecular brain 20100101

• A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise.

  PloS one 20100101

• Endocytosis of MPO in marginal cells is regulated by PKC, protein phosphatase, ERK and PI3-K signaling cascades, but not by PKA and MEK signaling cascades.

  ORL; journal for oto-rhino-laryngology and its related specialties 20100101

• R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair.

  Molecular cancer 20100101

• Eicosanoids in the innate immune response: TLR and non-TLR routes.

  Mediators of inflammation 20100101

• An acidic pH and activation of phosphoinositide 3-kinase stimulate differentiation of pancreatic progenitors into insulin-producing cells.

  Transplantation proceedings 20100101

• Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.

  PloS one 20100101

• Ghrelin in diabetes and metabolic syndrome.

  International journal of peptides 20100101

• Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications.

  International journal of peptides 20100101

• Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo.

  Radiation oncology (London, England) 20100101

• Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice.

  PloS one 20100101

• Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining.

  Journal of nucleic acids 20100101

• Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways.

  Oxidative medicine and cellular longevity 20100101

• Tumour suppressor function of MDA-7/IL-24 in human breast cancer.

  Cancer cell international 20100101

• Multidrug resistance protein transporter and Ins(1,4,5)P₃-sensitive Ca²+-signaling involved in adenosine triphosphate export via Gq protein-coupled NK₂-receptor stimulation with neurokinin A.

  Journal of pharmacological sciences 20100101

• TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.

  PloS one 20100101

• Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination.

  PloS one 20100101

• HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.

  PloS one 20100101

• Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.

  PloS one 20100101

• Augmentation of neovascularization in murine hindlimb ischemia by combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells transplantation.

  Journal of biomedical science 20100101

• Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical targets.

  Clinical and molecular allergy : CMA 20100101

• Nano rare-earth oxides induced size-dependent vacuolization: an independent pathway from autophagy.

  International journal of nanomedicine 20100101

• Dynamic changes to survivin subcellular localization are initiated by DNA damage.

  OncoTargets and therapy 20100101

• MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes.

  PloS one 20100101

• BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation.

  PloS one 20100101

• Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression.

  Respiratory research 20100101

• eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.

  PloS one 20100101

• BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress.

  Journal of nucleic acids 20100101

• Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection.

  BMC immunology 20100101

• The p110α and p110β isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells.

  Mediators of inflammation 20100101

• JAB1/CSN5: a new player in cell cycle control and cancer.

  Cell division 20100101

• The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release.

  Molecular immunology 20100101

• Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.

  PloS one 20100101

• PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes.

  BMC immunology 20100101

• Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.

  Breast cancer research : BCR 20100101

• Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells.

  PloS one 20100101

• Characterization of human platelet binding of recombinant T cell receptor ligand.

  Journal of neuroinflammation 20100101

• Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.

  PloS one 20100101

• Versican G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing EGF receptor signaling.

  PloS one 20100101

• Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.

  Breast cancer research : BCR 20100101

• Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase.

  Stem cell research & therapy 20100101

• Erythropoietin improves the survival of fat tissue after its transplantation in nude mice.

  PloS one 20100101

• Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation.

  Molecular cancer 20100101

• Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase.

  Molecular cancer 20100101

• Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.

  PloS one 20100101

• Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.

  BMC systems biology 20100101

• Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt.

  Journal of molecular signaling 20100101

• A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.

  PloS one 20100101

• A mutant of SWAP-70, a phosphatidylinositoltrisphosphate binding protein, transforms mouse embryo fibroblasts, which is inhibited by sanguinarine.

  PloS one 20100101

• Involvement of signaling molecules on na/h exchanger-1 activity in human monocytes.

  The open cardiovascular medicine journal 20100101

• Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway.

  BMC complementary and alternative medicine 20100101

• Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.

  PloS one 20100101

• Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells.

  BMC biology 20100101

• A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.

  PloS one 20100101

• The effect of DNA-dependent protein kinase on adeno-associated virus replication.

  PloS one 20100101

• mTORC1-S6K activation by endotoxin contributes to cytokine up-regulation and early lethality in animals.

  PloS one 20100101

• An intact centrosome is required for the maintenance of polarization during directional cell migration.

  PloS one 20100101

• Translational up-regulation and high-level protein expression from plasmid vectors by mTOR activation via different pathways in PC3 and 293T cells.

  PloS one 20100101

• The transcriptional response in human umbilical vein endothelial cells exposed to insulin: a dynamic gene expression approach.

  PloS one 20100101

• The phospholipase D1 pathway modulates macroautophagy.

  Nature communications 20100101

• Effects of neurosteroids on the human corticotropin-releasing hormone gene.

  Pharmacological reports : PR 20100101

• Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?

  F1000 biology reports 20100101

• Mechanisms underlying the endothelium-dependent vasodilatory effect of an aqueous extract of Elaeis Guineensis Jacq. (Arecaceae) in porcine coronary artery rings.

  African journal of traditional, complementary, and alternative medicines : AJTCAM 20100101

• Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.

  Oxidative medicine and cellular longevity 20100101

• Pertussis toxin nullifies the depolarization of the membrane potential and the stimulation of the rapid phase of Ca entry through L-type calcium channels that are produced by follicle stimulating hormone in 10- to 12-day-old rat Sertoli cells.

  Frontiers in physiology 20100101

• [Pharmacological PI 3-kinase inhibitors induce radioprotective effect in Drosophila melanogaster imago].

  Radiatsionnaia biologiia, radioecologiia 20100101

• Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation.

  Frontiers in microbiology 20100101

• Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update.

  Sensors (Basel, Switzerland) 20100101

• Wortmannin potentiates roscovitine-induced growth inhibition in human solid tumor cells by repressing PI3K/Akt pathway.

  Cancer letters 20091228

• Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells.

  The Journal of biological chemistry 20091218

• The TryPIKinome of five human pathogenic trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum--new tools for designing specific inhibitors.

  Biochemical and biophysical research communications 20091218

• Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha.

  ACS chemical biology 20091218

• Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.

  Bioscience reports 20091215

• Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway.

  Experimental cell research 20091210

• Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.

  American journal of respiratory cell and molecular biology 20091201

• Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis.

  Cardiovascular research 20091201

• Oleate protects against palmitate-induced insulin resistance in L6 myotubes.

  The British journal of nutrition 20091201

• Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells.

  Fertility and sterility 20091201

• AMP-activated protein kinase facilitates avian reovirus to induce mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 3/6 signalling that is beneficial for virus replication.

  The Journal of general virology 20091201

• Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway.

  Journal of leukocyte biology 20091201

• Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

  Journal of cellular physiology 20091201

• PKCalpha-MAPK/ERK-phospholipase A2 signaling is required for human melanoma-enhanced brain endothelial cell proliferation and motility.

  Microvascular research 20091201

• Metallothionein-III provides neuronal protection through activation of nuclear factor-kappaB via the TrkA/phosphatidylinositol-3 kinase/Akt signaling pathway.

  Toxicological sciences : an official journal of the Society of Toxicology 20091201

• Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons.

  Molecular pharmacology 20091201

• Naringin inhibits matrix metalloproteinase-9 expression and AKT phosphorylation in tumor necrosis factor-alpha-induced vascular smooth muscle cells.

  Molecular nutrition & food research 20091201

• Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibalpha shedding.

  American journal of physiology. Heart and circulatory physiology 20091201

• Excitation of locus coeruleus noradrenergic neurons by thyrotropin-releasing hormone.

  The Journal of physiology 20091201

• Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1alpha and phosphoinositide 3-kinase/Akt activation.

  Annals of surgery 20091201

• Insulin induced translocation of Na+/K+ -ATPase is decreased in the heart of streptozotocin diabetic rats.

  Acta pharmacologica Sinica 20091201

• CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.

  PLoS pathogens 20091201

• Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.

  Canadian journal of physiology and pharmacology 20091201

• [PI3-kinase mediates activity of RhoA and interaction of RhoA with mDia1 in thrombin-induced platelet aggregation].

  Zhongguo shi yan xue ye xue za zhi 20091201

• Differential regulation of Akt phosphorylation in endometriosis.

  Reproductive biomedicine online 20091201

• Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells.

  Osaka city medical journal 20091201

• Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling.

  Immune network 20091201

• Interferon response and viral evasion by members of the family rhabdoviridae.

  Viruses 20091201

• Insulin-like growth factor-I-induced androgen receptor activation is mediated by the PI3K/Akt pathway in C2C12 skeletal muscle cells.

  Molecules and cells 20091130

• Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.

  The Journal of biological chemistry 20091127

• ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase.

  The Journal of biological chemistry 20091120

• Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes.

  The Journal of physiology 20091115

• Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion.

  Cancer research 20091115

• The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats.

  Brain research 20091110

• Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation.

  Biochemical and biophysical research communications 20091106

• Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.

  Cell metabolism 20091104

• Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha.

  Breast cancer research and treatment 20091101

• Insulin activates the PI3K-Akt survival pathway in vulnerable neurons following global brain ischemia.

  Neurological research 20091101

• Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect.

  Neurochemical research 20091101

• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons.

  Journal of neuroscience research 20091101

• Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells.

  Biology of reproduction 20091101

• Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3beta/mTOR signaling pathway.

  Basic research in cardiology 20091101

• Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling.

  Bone 20091101

• Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling.

  Molecular & cellular proteomics : MCP 20091101

• Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity.

  Journal of molecular and cellular cardiology 20091101

• Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation.

  Experimental neurology 20091101

• Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.

  Cardiovascular research 20091101

• Early effects of lasonolide a on pancreatic cancer cells.

  The Journal of pharmacology and experimental therapeutics 20091101

• Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1.

  The Journal of pharmacology and experimental therapeutics 20091101

• Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats.

  American journal of physiology. Heart and circulatory physiology 20091101

• Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism.

  Journal of virology 20091101

• A wortmannin-cetuximab as a double drug.

  Bioconjugate chemistry 20091101

• In vitro enhancement effect of humic acid on the progression of lung cancer cells.

  Chemico-biological interactions 20091030

• Leptin 'gates' thermogenic action of thyrotropin-releasing hormone in the hindbrain.

  Brain research 20091027

• Involvement of PI3 kinase and MAP kinase in IGF-I- and insulin-induced oocyte maturation in Cyprinus carpio.

  Molecular and cellular endocrinology 20091015

• Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1.

  The Biochemical journal 20091015

• The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling.

  Human molecular genetics 20091015

• IL-4R(alpha), a new member that associates with Syk kinase: implication in IL-4-induced human neutrophil functions.

  Journal of immunology (Baltimore, Md. : 1950) 20091015

• Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells.

  Chemico-biological interactions 20091007

• Resistance to acute NO-mimetic and EDHF-mimetic effects of leptin in the metabolic syndrome.

  Life sciences 20091007

• Mechanisms of uterine contractility in laying hens.

  Animal reproduction science 20091001

• Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.

  The Biochemical journal 20091001

• The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production.

  Molecular endocrinology (Baltimore, Md.) 20091001

• Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate.

  American journal of physiology. Cell physiology 20091001

• Mechanism involved in phagocytosis and killing of Listeria monocytogenes by Acanthamoeba polyphaga.

  Parasitology research 20091001

• IGF-I activates the mouse type IIb myosin heavy chain gene.

  American journal of physiology. Cell physiology 20091001

• A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

  American journal of physiology. Cell physiology 20091001

• Inhibitory effect of ETB receptor on Na(+)-K(+) ATPase activity by extracellular Ca(2+) entry and Ca(2+) release from the endoplasmic reticulum in renal proximal tubule cells.

  Hypertension research : official journal of the Japanese Society of Hypertension 20091001

• Angiotensin II maintains cerebral vascular relaxation via EGF receptor transactivation and ERK1/2.

  American journal of physiology. Heart and circulatory physiology 20091001

• Green tea polyphenols inhibit plasminogen activator inhibitor-1 expression and secretion in endothelial cells.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Enamel matrix derivative protein stimulated wound healing via phosphoinositide 3-kinase.

  Journal of periodontology 20091001

• Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.

  Journal of medicinal food 20091001

• Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms.

  The Journal of biological chemistry 20090925

• Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.

  FEBS letters 20090917

• Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages.

  The Biochemical journal 20090914

• Signaling pathway involved in hypoxia-inducible factor-1alpha regulation in hypoxic-ischemic cortical neurons in vitro.

  Neuroscience letters 20090911

• Changes in expression and activity of the secretory pathway Ca2+ ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells cultured at different glucose concentrations.

  Bioscience reports 20090902

• Induction of copper/zinc-superoxide dismutase by CCL5/CCR5 activation causes tumour necrosis factor-alpha and reactive oxygen species production in macrophages.

  Immunology 20090901

• Azithromycin has an antiproliferative and autophagic effect on airway smooth muscle cells.

  The European respiratory journal 20090901

• Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.

  Pflugers Archiv : European journal of physiology 20090901

• Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells.

  Molecular endocrinology (Baltimore, Md.) 20090901

• Generation of dopamine neurons with improved cell survival and phenotype maintenance using a degradation-resistant nurr1 mutant.

  Stem cells (Dayton, Ohio) 20090901

• Involvement of phosphatidylinositol 3-kinase in cAMP- and cGMP-induced duodenal epithelial CFTR activation in mice.

  American journal of physiology. Cell physiology 20090901

• Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.

  Diabetes 20090901

• Scratch wound closure of C2C12 mouse myoblasts is enhanced by human platelet lysate.

  Cell biology international 20090901

• Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function.

  Apoptosis : an international journal on programmed cell death 20090901

• Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.

  Respirology (Carlton, Vic.) 20090901

• CD137 ligand-mediated reverse signals increase cell viability and cytokine expression in murine myeloid cells: involvement of mTOR/p70S6 kinase and Akt.

  European journal of immunology 20090901

• Carbamylated erythropoietin protects the myocardium from acute ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism.

  Surgery 20090901

• Prostate-derived factor--a novel inhibitor of drug-induced cell death in colon cancer cells.

  Molecular cancer therapeutics 20090901

• Modeling glioma growth and invasion in Drosophila melanogaster.

  Neoplasia (New York, N.Y.) 20090901

• Macropinocytosis contributes to the macrophage foam cell formation in RAW264.7 cells.

  Acta biochimica et biophysica Sinica 20090901

• PI-3 kinase pathway can mediate the effect of TGF-beta1 in inducing the expression of SHARP-2 in LLC-PK1 cells.

  Journal of Zhejiang University. Science. B 20090901

• AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells.

  Journal of cellular and molecular medicine 20090901

• Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation.

  Biology of the cell 20090825

• Clathrin-mediated endocytosis of quantum dot-peptide conjugates in living cells.

  ACS nano 20090825

• Immediate neuronal preconditioning by NS1619.

  Brain research 20090818

• Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.

  International journal of cancer 20090815

• Hepatocyte growth factor protects hepatocytes against oxidative injury induced by ethanol metabolism.

  Free radical biology & medicine 20090815

• Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2).

  The Biochemical journal 20090815

• Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20090815

• Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha.

  Cancer research 20090815

• Pentacyclic furanosteroids: the synthesis of potential kinase inhibitors related to viridin and wortmannolone.

  The Journal of organic chemistry 20090807

• Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.

  Bioscience reports 20090801

• Breast cancer cells expressing stem cell markers CD44+ CD24 lo are eliminated by Numb-1 peptide-activated T cells.

  Cancer immunology, immunotherapy : CII 20090801

• P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.

  Glia 20090801

• Platelet lysate promotes in vitro wound scratch closure of human dermal fibroblasts: different roles of cell calcium, P38, ERK and PI3K/AKT.

  Journal of cellular and molecular medicine 20090801

• Angiopoietin-1 induces neurite outgrowth of PC12 cells in a Tie2-independent, beta1-integrin-dependent manner.

  Neuroscience research 20090801

• Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway.

  International immunopharmacology 20090801

• Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.

  Journal of cellular biochemistry 20090801

• Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime.

  The Journal of general virology 20090801

• (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of phosphatidylinositol 3-kinase/Akt signaling and anti-inflammatory action in vivo.

  The Journal of pharmacology and experimental therapeutics 20090801

• Sevoflurane- and desflurane-induced human myocardial post-conditioning through Phosphatidylinositol-3-kinase/Akt signalling.

  Acta anaesthesiologica Scandinavica 20090801

• Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.

  The Journal of physiology 20090801

• The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5.

  Journal of neurochemistry 20090801

• A stabilized demethoxyviridin derivative inhibits PI3 kinase.

  Bioorganic & medicinal chemistry letters 20090801

• Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.

  Critical care medicine 20090801

• Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways.

  Nephron. Experimental nephrology 20090801

• Investigating GABA and its function in platelets as compared to neurons.

  Platelets 20090801

• Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.

  Arthritis and rheumatism 20090801

• LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells.

  Anticancer research 20090801

• Wortmannin inhibits K562 leukemic cells by regulating PI3k/Akt channel in vitro.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090801

• Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells.

  Molecular cancer research : MCR 20090801

• Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.

  PLoS pathogens 20090801

• Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis.

  PLoS pathogens 20090801

• Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.

  Annals of the New York Academy of Sciences 20090801

• Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20090801

• Toll-like receptors and myocardial ischemia/reperfusion, inflammation, and injury.

  Current cardiology reviews 20090801

• Basic fibroblast growth factor increases intracellular magnesium concentration through the specific signaling pathways.

  Molecules and cells 20090731

• delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation.

  Experimental cell research 20090715

• Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelium injury.

  Free radical biology & medicine 20090715

• Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.

  Cardiovascular research 20090715

• Function and regulation of phospholipid signalling in plants.

  The Biochemical journal 20090715

• Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells.

  The EMBO journal 20090708

• Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090708

• Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells.

  Gastroenterology 20090701

• A selective estrogen receptor modulator inhibits TNF-alpha-induced apoptosis by activating ERK1/2 signaling pathway in vascular endothelial cells.

  Vascular pharmacology 20090701

• Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules.

  Journal of cellular physiology 20090701

• Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys.

  Diabetes 20090701

• Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity.

  Molecular and cellular neurosciences 20090701

• Insulin increases D5 dopamine receptor expression and function in renal proximal tubule cells from Wistar-Kyoto rats.

  American journal of hypertension 20090701

• Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle.

  Biochimie 20090701

• Facilitation of myocardial PI3K/Akt/nNOS signaling contributes to ethanol-evoked hypotension in female rats.

  Alcoholism, clinical and experimental research 20090701

• Inhibitory effects of leptin on pancreatic alpha-cell function.

  Diabetes 20090701

• Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).

  The Biochemical journal 20090701

• Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase.

  The Journal of physiology 20090701

• Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells.

  FEMS immunology and medical microbiology 20090701

• Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injury.

  American journal of physiology. Heart and circulatory physiology 20090701

• Wortmannin induces homotypic fusion of plant prevacuolar compartments.

  Journal of experimental botany 20090701

• Identification of the large-conductance background K+ channel in mouse B cells as TREK-2.

  American journal of physiology. Cell physiology 20090701

• Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity.

  Molecular immunology 20090701

• An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons.

  Apoptosis : an international journal on programmed cell death 20090701

• Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.

  Cancer research 20090701

• Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.

  PLoS pathogens 20090701

• PIKfyve regulation of endosome-linked pathways.

  Traffic (Copenhagen, Denmark) 20090701

• Rosiglitazone inhibits high glucose-induced apoptosis in human umbilical vein endothelial cells through the PI3K/Akt/eNOS pathway.

  Canadian journal of physiology and pharmacology 20090701

• TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation.

  Blood 20090625

• Anaplastic lymphoma kinase: signalling in development and disease.

  The Biochemical journal 20090615

• H-Ras and PI3K are required for the formation of circular dorsal ruffles induced by low-power laser irradiation.

  Journal of cellular physiology 20090601

• Low-power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway.

  Journal of cellular physiology 20090601

• Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090601

• The effect of TGF-beta2 on MMP-2 production and activity in highly metastatic human bladder carcinoma cell line 5637.

  Cancer investigation 20090601

• Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses.

  Journal of leukocyte biology 20090601

• Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.

  Journal of biochemistry 20090601

• Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.

  Molecular pharmacology 20090601

• Exogenous insulin stimulates glycogen accumulation in Rhipicephalus (Boophilus) microplus embryo cell line BME26 via PI3K/AKT pathway.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20090601

• Serum albumin protects from cytokine-induced pancreatic beta cell death by a phosphoinositide 3-kinase-dependent mechanism.

  Endocrine 20090601

• IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation.

  Microvascular research 20090601

• Low-amplitude pulses to the circulation through periodic acceleration induces endothelial-dependent vasodilatation.

  Journal of applied physiology (Bethesda, Md. : 1985) 20090601

• Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels.

  Journal of molecular and cellular cardiology 20090601

• Vasculogenic mimicry of acute leukemic bone marrow stromal cells.

  Leukemia 20090601

• Transient receptor potential canonical type 3 channels and blood pressure in humans.

  Journal of hypertension 20090601

• IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways.

  Journal of neurochemistry 20090601

• The mechanism by which ischemic postconditioning reduces reperfusion arrhythmias in rats remains elusive.

  Journal of cardiovascular pharmacology and therapeutics 20090601

• Apelin protects heart against ischemia/reperfusion injury in rat.

  Peptides 20090601

• Overexpression of thymosin beta4 increases pseudopodia formation in LNCaP prostate cancer cells.

  Biological & pharmaceutical bulletin 20090601

• The antiproliferative cytostatic effects of a self-activating viridin prodrug.

  Molecular cancer therapeutics 20090601

• [Role of phosphatidylinositol 3-kinase and myosin light chain kinase during the activation of thrombin receptors].

  Zhongguo shi yan xue ye xue za zhi 20090601

• PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis.

  Cellular & molecular immunology 20090601

• Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.

  The EMBO journal 20090520

• Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.

  International journal of cardiology 20090515

• Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake.

  Chemico-biological interactions 20090515

• Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression.

  Journal of immunology (Baltimore, Md. : 1950) 20090515

• Proteasome regulation of ULBP1 transcription.

  Journal of immunology (Baltimore, Md. : 1950) 20090515

• Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism.

  Molecular and cellular endocrinology 20090506

• Influence of progesterone on endometrial nitric oxide synthase expression.

  Fertility and sterility 20090501

• Modulation of rat neutrophil function in vitro by cis- and trans-MUFA.

  The British journal of nutrition 20090501

• Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin-dependent manner.

  Journal of cellular physiology 20090501

• Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells.

  Autophagy 20090501

• Stathmin, a microtubule regulatory protein, is associated with hypoxia-inducible factor-1alpha levels in human endometrial and endothelial cells.

  Endocrinology 20090501

• Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression.

  Diabetes 20090501

• Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS-AS160 in rat skeletal muscle.

  Diabetes 20090501

• Beta-hydroxy-beta-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways.

  Biochimica et biophysica acta 20090501

• Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress.

  Journal of neurochemistry 20090501

• Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose.

  American journal of physiology. Endocrinology and metabolism 20090501

• PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.

  Journal of molecular and cellular cardiology 20090501

• Hyperthermia-induced cardioprotection is potentiated by ischemic postconditioning in rats.

  Experimental biology and medicine (Maywood, N.J.) 20090501

• Study of the insulin signaling pathways in the regulation of ACAT1 expression in cultured macrophages.

  Cell biology international 20090501

• Autophagy protects neuron from Abeta-induced cytotoxicity.

  Autophagy 20090501

• PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells.

  Cancer biology & therapy 20090501

• Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.

  American journal of physiology. Heart and circulatory physiology 20090501

• Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage.

  Molecular biology of the cell 20090501

• HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism.

  Journal of immunology (Baltimore, Md. : 1950) 20090501

• Bacteria-induced uroplakin signaling mediates bladder response to infection.

  PLoS pathogens 20090501

• Disruption of glucose homeostasis and induction of insulin resistance by elevated free fatty acids in human L02 hepatocytes.

  Journal of endocrinological investigation 20090501

• Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells.

  Toxicology 20090428

• [Mechanism of granulocyte colony-stimulating factor for promoting cell viability of bone marrow mesenchymal stem cells.].

  Sheng li xue bao : [Acta physiologica Sinica] 20090425

• Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts.

  British journal of cancer 20090421

• Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

  Biochemical and biophysical research communications 20090417

• Epigallocatechin-3-gallate relaxes the isolated bovine ophthalmic artery: involvement of phosphoinositide 3-kinase-Akt-nitric oxide/cGMP signalling pathway.

  European journal of pharmacology 20090417

• Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization.

  Experimental cell research 20090415

• Transcriptional activation of the mixed lineage leukemia-p27Kip1 pathway by a somatostatin analogue.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090415

• Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis.

  Cancer research 20090415

• Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway.

  FEBS letters 20090402

• Apoptotic endothelial cells demonstrate increased adhesiveness for human mesenchymal stem cells.

  Journal of cellular physiology 20090401

• S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.

  Journal of cellular physiology 20090401

• Autophagy is involved in influenza A virus replication.

  Autophagy 20090401

• Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20090401

• Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells.

  The Journal of pharmacology and experimental therapeutics 20090401

• IKKbeta and the anti-adipogenic effect of platelet-derived growth factor in human abdominal subcutaneous preadipocytes.

  The Journal of endocrinology 20090401

• Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation.

  Autophagy 20090401

• TGF-beta effects on airway smooth muscle cell proliferation, VEGF release and signal transduction pathways.

  Respirology (Carlton, Vic.) 20090401

• Schlafen 3, a novel gene, regulates colonic mucosal growth during aging.

  American journal of physiology. Gastrointestinal and liver physiology 20090401

• Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival.

  Journal of cellular biochemistry 20090401

• Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis.

  Cytokine 20090401

• Naphthoimidazoles promote different death phenotypes in Trypanosoma cruzi.

  Parasitology 20090401

• Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases.

  Journal of veterinary pharmacology and therapeutics 20090401

• Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation.

  Journal of immunology (Baltimore, Md. : 1950) 20090401

• Anti-hypoxic effect of ginsenoside Rbl on neonatal rat cardiomyocytes is mediated through the specific activation of glucose transporter-4 ex vivo.

  Acta pharmacologica Sinica 20090401

• Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes.

  European journal of pharmacology 20090401

• Pancreatic differentiation from pluripotent stem cells: tweaking the system.

  Cell research 20090401

• Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils.

  PLoS pathogens 20090401

• A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20090401

• DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.

  Molecular cancer research : MCR 20090401

• Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity.

  Radiation research 20090401

• Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3.

  Annals of the New York Academy of Sciences 20090401

• Relaxin activates multiple cAMP signaling pathway profiles in different target cells.

  Annals of the New York Academy of Sciences 20090401

• Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo.

  Cancer science 20090401

• The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease.

  Aging 20090401

• DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide.

  Toxicology 20090329

• Effect of preischemic beta-adrenoceptor stimulation on postischemic contractile dysfunction.

  Life sciences 20090327

• Angiotensin II induces MMP 2 activity via FAK/JNK pathway in human endothelial cells.

  Biochemical and biophysical research communications 20090320

• Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.

  Circulation research 20090313

• Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation.

  Circulation research 20090313

• Phosphatidylinositol-and related-kinases: a genome-wide survey of classes and subtypes in the Schistosoma mansoni genome for designing subtype-specific inhibitors.

  Biochemical and biophysical research communications 20090313

• Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways.

  Purinergic signalling 20090301

• Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice.

  The Journal of investigative dermatology 20090301

• Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells.

  The international journal of biochemistry & cell biology 20090301

• Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090301

• Zinc chloride stimulates DNA synthesis of mouse embryonic stem cells: involvement of PI3K/Akt, MAPKs, and mTOR.

  Journal of cellular physiology 20090301

• The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging.

  Molecular immunology 20090301

• Insulin stimulates ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori.

  Insect biochemistry and molecular biology 20090301

• The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning.

  Experimental eye research 20090301

• Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway.

  Journal of biochemistry 20090301

• Identification of extracellular delta-catenin accumulation for prostate cancer detection.

  The Prostate 20090301

• Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway.

  Molecular immunology 20090301

• Antifolate/folate-activated HGF/c-Met signalling pathways in mouse kidneys-the putative role of their downstream effectors in cross-talk with androgen receptor.

  Archives of biochemistry and biophysics 20090301

• 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20090301

• PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.

  American journal of physiology. Heart and circulatory physiology 20090301

• Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.

  The Journal of allergy and clinical immunology 20090301

• Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090301

• Xenon preconditioning: the role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats.

  Anesthesia and analgesia 20090301

• Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.

  Molecular cancer therapeutics 20090301

• Thymosin beta4 induces endothelial progenitor cell migration via PI3K/Akt/eNOS signal transduction pathway.

  Journal of cardiovascular pharmacology 20090301

• Telmisartan increases the permeability of endothelial cells through zonula occludens-1.

  Biological & pharmaceutical bulletin 20090301

• Fibroin-derived peptides stimulate glucose transport in normal and insulin-resistant 3T3-L1 adipocytes.

  Biological & pharmaceutical bulletin 20090301

• Reduced volume-regulated outwardly rectifying anion channel activity in ventricular myocyte of type 1 diabetic mice.

  The journal of physiological sciences : JPS 20090301

• Post-conditioning restores pre-ischaemic receptor coupling in rat isolated hearts.

  British journal of pharmacology 20090301

• Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord.

  Neuroscience 20090218

• Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells.

  The Journal of biological chemistry 20090206

• Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling.

  Biochemical and biophysical research communications 20090206

• ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.

  Bioorganic & medicinal chemistry 20090201

• Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation.

  Amino acids 20090201

• Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways.

  The Journal of nutritional biochemistry 20090201

• Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway.

  Diabetes, obesity & metabolism 20090201

• Ellipticine-induced apoptosis depends on Akt translocation and signaling in lung epithelial cancer cells.

  Lung cancer (Amsterdam, Netherlands) 20090201

• PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.

  Leukemia research 20090201

• Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels.

  Pflugers Archiv : European journal of physiology 20090201

• Fluvastatin reduces pulmonary vein spontaneous activity through nitric oxide pathway.

  Journal of cardiovascular electrophysiology 20090201

• Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein.

  Journal of cellular and molecular medicine 20090201

• Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway.

  Experimental brain research 20090201

• Evidence for a novel chemotactic C1q domain-containing factor in the leech nerve cord.

  Molecular immunology 20090201

• GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner.

  Cellular signalling 20090201

• Autophagy in hypoxia-ischemia induced brain injury: evidence and speculations.

  Autophagy 20090201

• Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts.

  American journal of hypertension 20090201

• Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes.

  The Journal of physiology 20090201

• BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner.

  American journal of physiology. Cell physiology 20090201

• Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cells.

  Cell biology international 20090201

• Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB/c but not C57BL/6 macrophages.

  Microbes and infection 20090201

• Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum.

  Bioorganic & medicinal chemistry 20090201

• Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat.

  Journal of neurochemistry 20090201

• Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

  PLoS biology 20090201

• Wortmannin inhibits the increase in myofilament Ca(2+) sensitivity induced by cross-talk of endothelin-1 with norepinephrine in canine ventricular myocardium.

  Journal of pharmacological sciences 20090201

• Recombinant adeno-associated virus-based gene transfer of cathelicidin induces therapeutic neovascularization preferentially via potent collateral growth.

  Human gene therapy 20090201

• [VEGF165-induced angiogenesis by regulating intracellular free Mg2+ in HUVECs].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090201

• Whey protein ingestion activates mTOR-dependent signalling after resistance exercise in young men: a double-blinded randomized controlled trial.

  Nutrients 20090201

• Morphine enhances microglial migration through modulation of P2X4 receptor signaling.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

• Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production.

  The Journal of biological chemistry 20090116

• Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells.

  The Biochemical journal 20090115

• Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.

  The Journal of physiology 20090115

• Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways.

  Regulatory peptides 20090108

• Alphaxalone, a neurosteroid anaesthetic, increases the activity of the glutamate transporter type 3 expressed in Xenopus oocytes.

  European journal of pharmacology 20090105

• Ischemic postconditioning in pigs: no causal role for RISK activation.

  Circulation research 20090102

• An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.

  Circulation research 20090102

• IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways.

  Osteoarthritis and cartilage 20090101

• Up-regulation of placental leptin by human chorionic gonadotropin.

  Endocrinology 20090101

• Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes and the role of the PI3-K/PKB pathway.

  Molecular and cellular biochemistry 20090101

• The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I.

  Endocrinology 20090101

• Uniaxial cyclic stretch increases glucose uptake into C2C12 myotubes through a signaling pathway independent of insulin-like growth factor I.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090101

• EGF and HGF levels are increased during active HBV infection and enhance survival signaling through extracellular matrix interactions in primary human hepatocytes.

  International journal of cancer 20090101

• YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells.

  Molecular pharmacology 20090101

• Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization.

  Medical oncology (Northwood, London, England) 20090101

• Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.

  Traffic (Copenhagen, Denmark) 20090101

• WAVE2 is regulated by multiple phosphorylation events within its VCA domain.

  Cell motility and the cytoskeleton 20090101

• High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene.

  Autophagy 20090101

• Coenzyme Q deficiency triggers mitochondria degradation by mitophagy.

  Autophagy 20090101

• Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

• Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.

  Journal of pharmacological sciences 20090101

• Phosphoinositide 3-kinase targeting by the beta galactoside binding protein cytokine negates akt gene expression and leads aggressive breast cancer cells to apoptotic death.

  Breast cancer research : BCR 20090101

• Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel.

  British journal of pharmacology 20090101

• Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats.

  Nutrition & metabolism 20090101

• eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries.

  Journal of vascular research 20090101

• Phosphoinositide (PI) 3-kinase assays.

  Methods in molecular biology (Clifton, N.J.) 20090101

• Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation.

  BMC immunology 20090101

• Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-induced activation of PI3K/Akt and NF-kB signaling pathways regulates expression of CXCL10 in epithelial cells.

  Cellular immunology 20090101

• Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells.

  Fibrogenesis & tissue repair 20090101

• Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II.

  PloS one 20090101

• Signal transduction in the footsteps of goethe and schiller.

  Cell communication and signaling : CCS 20090101

• Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells.

  Immunobiology 20090101

• PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk.

  Molecular systems biology 20090101

• Urocortin II induces nitric oxide production through cAMP and Ca2+ related pathways in endothelial cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

• Proliferative effects of bovine and porcine thyroglobulins on thyroid epithelial cells.

  Endocrine journal 20090101

• c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.

  PloS one 20090101

• Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.

  PloS one 20090101

• Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the 'basal' breast cancer subgroup.

  PloS one 20090101

• Molecular mechanisms of cell proliferation induced by low power laser irradiation.

  Journal of biomedical science 20090101

• Characterization of dengue virus entry into HepG2 cells.

  Journal of biomedical science 20090101

• Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells.

  Molecular vision 20090101

• The protein Nalpha-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells.

  BMC research notes 20090101

• The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events.

  Molecular neurodegeneration 20090101

• S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton.

  PloS one 20090101

• Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.

  Autonomic & autacoid pharmacology 20090101

• Androgen deprivation modulates the inflammatory response induced by irradiation.

  BMC cancer 20090101

• Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins.

  BMC cancer 20090101

• VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway.

  PloS one 20090101

• Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells.

  BMC physiology 20090101

• All-you-can-eat: autophagy in neurodegeneration and neuroprotection.

  Molecular neurodegeneration 20090101

• Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

  Molecular systems biology 20090101

• Modulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanine.

  Immunity & ageing : I & A 20090101

• Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation.

  PloS one 20090101

• Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation.

  BMC immunology 20090101

• Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?

  Critical care (London, England) 20090101

• Vascular effects of rapid-acting insulin analogs in the diabetic patient: a review.

  Vascular health and risk management 20090101

• Interferon-alpha-induced mTOR activation is an anti-hepatitis C virus signal via the phosphatidylinositol 3-kinase-Akt-independent pathway.

  Journal of gastroenterology 20090101

• A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.

  BMC immunology 20090101

• In vivo reorganization of the actin cytoskeleton in leaves of Nicotiana tabacum L. transformed with plastin-GFP. Correlation with light-activated chloroplast responses.

  BMC plant biology 20090101

• The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-kinase signaling pathway.

  Lipids in health and disease 20090101

• Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20090101

• PI3Kgamma differentially regulates FcepsilonRI-mediated degranulation and migration of mast cells by and toward antigen.

  International archives of allergy and immunology 20090101

• Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K/Akt pathway.

  Cytotherapy 20090101

• Gbetagamma-copurified lipid kinase impurity from Sf9 cells.

  Protein and peptide letters 20090101

• PI(3,4,5)P3 potentiates phospholipase C-beta activity.

  Journal of receptor and signal transduction research 20090101

• Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols.

  Vascular pharmacology 20090101

• SNX4 in complex with clathrin and dynein: implications for endosome movement.

  PloS one 20090101

• Histidine-rich glycoprotein and concanavalin A synergistically stimulate the phosphatidylinositol 3-kinase-independent signaling pathway in leukocytes leading to increased cell adhesion and changes in cell morphology.

  Cellular immunology 20090101

• Young environment reverses the declined activity of aged rat-derived endothelial progenitor cells: involvement of the phosphatidylinositol 3-kinase/Akt signaling pathway.

  Annals of vascular surgery 20090101

• Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.

  PloS one 20090101

• A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation.

  PloS one 20090101

• Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer.

  BMC cancer 20090101

• Essential roles of mTOR/Akt pathway in Aurora-A cell transformation.

  International journal of biological sciences 20090101

• Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells.

  BMC cell biology 20090101

• A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases.

  Molecular brain 20090101

• Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

  PloS one 20090101

• Bone marrow mesenchymal stem cells undergo nemosis and induce keratinocyte wound healing utilizing the HGF/c-Met/PI3K pathway.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20090101

• Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response.

  PloS one 20090101

• Reduced susceptibility to ischemia-induced arrhythmias in the preconditioned rat heart is independent of PI3-kinase/Akt.

  Physiological research 20090101

• PEDF inhibits VEGF- and EPO- induced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation.

  Angiogenesis 20090101

• Major signaling pathways in migrating neuroblasts.

  Frontiers in molecular neuroscience 20090101

• Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors.

  Molecular pain 20090101

• TIS11 family proteins and their roles in posttranscriptional gene regulation.

  Journal of biomedicine & biotechnology 20090101

• Urinary trypsin inhibitors afford cardioprotective effects through activation of PI3K-Akt and ERK signal transduction and inhibition of p38 MAPK and JNK.

  Cardiology 20090101

• Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells.

  Molecular vision 20090101

• Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage.

  BMC neuroscience 20090101

• Fibronectin increases survival of rat hepatic stellate cells--a novel profibrogenic mechanism of fibronectin.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

• A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling.

  PloS one 20090101

• Techniques to study autophagy in plants.

  International journal of plant genomics 20090101

• Anti-proliferative activity of silver nanoparticles.

  BMC cell biology 20090101

• Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study.

  BMC cell biology 20090101

• The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells.

  BMC cancer 20090101

• Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding.

  Nutrition & metabolism 20090101

• Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.

  PloS one 20090101

• Membrane protein location-dependent regulation by PI3K (III) and rabenosyn-5 in Drosophila wing cells.

  PloS one 20090101

• Rac inhibition reverses the phenotype of fibrotic fibroblasts.

  PloS one 20090101

• Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells.

  Radiation oncology (London, England) 20090101

• Dynamic changes of neuroskeletal proteins in DRGs underlie impaired axonal maturation and progressive axonal degeneration in type 1 diabetes.

  Experimental diabetes research 20090101

• Key signalling nodes in mammary gland development and cancer: Myc.

  Breast cancer research : BCR 20090101

• Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.

  Molecular cancer 20090101

• Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists.

  PloS one 20090101

• Luteinizing hormone-induced Akt phosphorylation and androgen production are modulated by MAP Kinase in bovine theca cells.

  Journal of ovarian research 20090101

• Pleiotropic vasoprotective effects of statins: the chicken or the egg?

  Drug design, development and therapy 20090101

• Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.

  PloS one 20090101

• Involvement of phosphatidylinositol kinases in the effect of oxidized glutathione and drug glutoxim on Na+ transport in frog skin.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101

• Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity.

  PloS one 20090101

• Intein-mediated site-specific conjugation of Quantum Dots to proteins in vivo.

  Journal of nanobiotechnology 20090101

• N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling.

  PloS one 20090101

• A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.

  PloS one 20090101

• ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis.

  PloS one 20090101

• Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization.

  BMC developmental biology 20090101

• TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.

  BMC molecular biology 20090101

• Chemogenomic profiling predicts antifungal synergies.

  Molecular systems biology 20090101

• Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during in vitro maturation of porcine COCs.

  Journal of ovarian research 20090101

• Hypercholesterolaemic serum increases the permeability of endothelial cells through zonula occludens-1 with phosphatidylinositol 3-kinase signaling pathway.

  Journal of biomedicine & biotechnology 20090101

• The N-terminal domain of y-box binding protein-1 induces cell cycle arrest in g2/m phase by binding to cyclin d1.

  International journal of cell biology 20090101

• The roles, mechanisms, and controversies of autophagy in mammalian biology.

  F1000 biology reports 20090101

• Ent-pimara-8(14), 15-dien-19-oic acid isolated from the roots of Aralia cordata inhibits induction of inflammatory mediators by blocking NF-kappaB activation and mitogen-activated protein kinase pathways.

  European journal of pharmacology 20081228

• Control of motoneuron survival by angiogenin.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081224

• Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase.

  The Biochemical journal 20081215

• Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.

  Analytical biochemistry 20081215

• Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20081215

• Up-regulation of IAPs by PI-3K: a cell survival signal-mediated anti-apoptotic mechanism.

  Biochemical and biophysical research communications 20081212

• LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway.

  Biochemical and biophysical research communications 20081205

• Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle.

  Biochemical and biophysical research communications 20081205

• Bradykinin stimulates glutamate uptake via both B1R and B2R activation in a human retinal pigment epithelial cells.

  Life sciences 20081205

• Pretreatment with granulocyte colony-stimulating factor attenuated renal ischaemia and reperfusion injury via activation of PI3/Akt signal pathway.

  Nephrology (Carlton, Vic.) 20081201

• TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes.

  Experimental dermatology 20081201

• Insulin enhancement of cytokine-induced coagulation/inflammation-related gene transcription in hepatocytes.

  Endocrine journal 20081201

• Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation.

  Prostaglandins & other lipid mediators 20081201

• Antilipolytic effect of calcium-sensing receptor in human adipocytes.

  Molecular and cellular biochemistry 20081201

• Nitric oxide and MCP-1 regulation in LPS activated rat Kupffer cells.

  Molecular and cellular biochemistry 20081201

• Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3-kinase signal transduction.

  Cardiovascular drugs and therapy 20081201

• The vacuolar transport of aleurain-GFP and 2S albumin-GFP fusions is mediated by the same pre-vacuolar compartments in tobacco BY-2 and Arabidopsis suspension cultured cells.

  The Plant journal : for cell and molecular biology 20081201

• Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase.

  Journal of neuroscience research 20081201

• Rapid activation by 3,5,3'-L-triiodothyronine of adenosine 5'-monophosphate-activated protein kinase/acetyl-coenzyme a carboxylase and akt/protein kinase B signaling pathways: relation to changes in fuel metabolism and myosin heavy-chain protein content in rat gastrocnemius muscle in vivo.

  Endocrinology 20081201

• Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose.

  Endocrinology 20081201

• Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury.

  Neurobiology of disease 20081201

• Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways.

  International journal of cancer 20081201

• Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells.

  Cellular signalling 20081201

• Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling.

  Diabetes 20081201

• UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation.

  Purinergic signalling 20081201

• The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3.

  Cellular signalling 20081201

• Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle.

  Diabetes 20081201

• Applying surface plasmon resonance to monitor the IgE-mediated activation of human basophils.

  Allergology international : official journal of the Japanese Society of Allergology 20081201

• Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade.

  Journal of neurochemistry 20081201

• ERK and p38 pathways regulate amino acid signalling.

  Biochimica et biophysica acta 20081201

• High glucose activates PKC-zeta and NADPH oxidase through autocrine TGF-beta1 signaling in mesangial cells.

  American journal of physiology. Renal physiology 20081201

• Gyrating clathrin: highly dynamic clathrin structures involved in rapid receptor recycling.

  Traffic (Copenhagen, Denmark) 20081201

• Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles.

  American journal of physiology. Heart and circulatory physiology 20081201

• o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways.

  Toxicology and applied pharmacology 20081201

• Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2alpha on neurosecretory vesicles.

  Molecular biology of the cell 20081201

• Infectious adenovirus type 2 transport through early but not late endosomes.

  Traffic (Copenhagen, Denmark) 20081201

• The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.

  Journal of immunology (Baltimore, Md. : 1950) 20081201

• Expression and purification of PI3 kinase alpha and development of an ATP depletion and an alphascreen PI3 kinase activity assay.

  Journal of biomolecular screening 20081201

• ICAM-1 has a critical role in the regulation of metastatic melanoma tumor susceptibility to CTL lysis by interfering with PI3K/AKT pathway.

  Cancer research 20081201

• The genomic analysis of lactic acidosis and acidosis response in human cancers.

  PLoS genetics 20081201

• G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.

  Environmental health perspectives 20081201

• Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells.

  FEBS letters 20081126

• Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081126

• Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.

  Circulation research 20081121

• Chronic restraint stress promotes immune suppression through toll-like receptor 4-mediated phosphoinositide 3-kinase signaling.

  Journal of neuroimmunology 20081115

• Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes.

  Experimental cell research 20081115

• Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells.

  Biochemical and biophysical research communications 20081114

• A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis.

  The Journal of biological chemistry 20081114

• Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells.

  Mutation research 20081110

• Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3'-kinase.

  Life sciences 20081107

• Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning.

  Circulation 20081104

• Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression.

  Cancer immunology, immunotherapy : CII 20081101

• SDF-1alpha/CXCR4 decreases endothelial progenitor cells apoptosis under serum deprivation by PI3K/Akt/eNOS pathway.

  Atherosclerosis 20081101

• Group B streptococcus exploits lipid rafts and phosphoinositide 3-kinase/Akt signaling pathway to invade human endometrial cells.

  American journal of obstetrics and gynecology 20081101

• Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes.

  Pflugers Archiv : European journal of physiology 20081101

• ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP.

  Pflugers Archiv : European journal of physiology 20081101

• Characterization of the transduction pathway involved in c-fos and c-jun expression induced by Aggregatibacter actinomycetemcomitans lipopolysaccharides in human gingival fibroblasts.

  International immunopharmacology 20081101

• Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism.

  Endocrinology 20081101

• Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.

  Journal of neurochemistry 20081101

• KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.

  Cellular signalling 20081101

• Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation.

  Peptides 20081101

• Role of adrenomedullin system in lipid metabolism and its signaling mechanism in cultured adipocytes.

  American journal of physiology. Regulatory, integrative and comparative physiology 20081101

• Differential signaling pathways in angiotensin II- and epidermal growth factor-stimulated hepatic C9 cells.

  Molecular pharmacology 20081101

• Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.

  Blood 20081101

• Enhanced induction of apoptosis in a radio-resistant bladder tumor cell line by combined treatments with X-rays and wortmannin.

  Radiation and environmental biophysics 20081101

• Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices.

  American journal of physiology. Heart and circulatory physiology 20081101

• Autophagy protects against hypoxic injury in C. elegans.

  Autophagy 20081101

• Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.

  Nature chemical biology 20081101

• Induction of autophagic cell death by a novel molecule is increased by hypoxia.

  Autophagy 20081101

• Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model.

  Anesthesiology 20081101

• Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade.

  International journal of molecular sciences 20081101

• Compartmentalization of phosphatidylinositol 4,5-bisphosphate signaling evidenced using targeted phosphatases.

  The Journal of biological chemistry 20081031

• Insulin-stimulated fusion of GLUT4 vesicles to plasma membrane is dependent on wortmannin-sensitive insulin signaling pathway in 3T3-L1 adipocytes.

  The Kobe journal of medical sciences 20081030

• Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion.

  The Journal of biological chemistry 20081024

• Strawberry extract caused endothelium-dependent relaxation through the activation of PI3 kinase/Akt.

  Journal of agricultural and food chemistry 20081022

• PI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.

  Blood 20081015

• Miyabenol A inhibits LPS-induced NO production via IKK/IkappaB inactivation in RAW 264.7 macrophages: possible involvement of the p38 and PI3K pathways.

  Journal of agricultural and food chemistry 20081008

• Insulin-like growth factor-I inhibits rat arterial K(ATP) channels through pI 3-kinase.

  Biochemical and biophysical research communications 20081003

• Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators.

  Pflugers Archiv : European journal of physiology 20081001

• Activation of autophagy in retinal ganglion cells.

  Journal of neuroscience research 20081001

• Rho-GDP dissociation inhibitor alpha downregulated by low shear stress promotes vascular smooth muscle cell migration and apoptosis: a proteomic analysis.

  Cardiovascular research 20081001

• Raloxifene protects endothelial cell function against oxidative stress.

  British journal of pharmacology 20081001

• Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice.

  Diabetes 20081001

• Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase.

  Diabetes 20081001

• Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.

  Biochimica et biophysica acta 20081001

• Renal activity of Akt kinase in obese Zucker rats.

  Experimental biology and medicine (Maywood, N.J.) 20081001

• Insulin-like growth factor-1 delays Fas-mediated apoptosis in human neutrophils through the phosphatidylinositol-3 kinase pathway.

  The Journal of endocrinology 20081001

• LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism.

  Toxicology and applied pharmacology 20081001

• GAS6-induced signaling in human endothelial cells is mediated by FOXO1a.

  Journal of thrombosis and haemostasis : JTH 20081001

• Caspase-3 activation as a key factor for HBx-transformed cell death.

  Cell proliferation 20081001

• TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.

  American journal of physiology. Cell physiology 20081001

• Phosphatidylinositol 3-kinase activity and asymmetrical accumulation of F-actin are necessary for establishment of cell polarity in the early development of monospores from the marine red alga Porphyra yezoensis.

  Journal of experimental botany 20081001

• Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor.

  American journal of physiology. Gastrointestinal and liver physiology 20081001

• Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway.

  Cytokine 20081001

• Premature chromosome condensation reveals DNA-PK independent pathways of chromosome break repair.

  International journal of oncology 20081001

• Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion.

  Pancreas 20081001

• Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex.

  Learning & memory (Cold Spring Harbor, N.Y.) 20081001

• Angiogenic factor thymidine phosphorylase increases cancer cell invasion activity in patients with gastric adenocarcinoma.

  Molecular cancer research : MCR 20081001

• Inhibition of superoxide generation and myeloperoxidase release by carvedilol after receptor and nonreceptor stimulation of human neutrophils.

  Neuro endocrinology letters 20081001

• Genes up- and down-regulated by dermcidin in breast cancer: a microarray analysis.

  Genetics and molecular research : GMR 20080930

• Nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb.

  The Journal of biological chemistry 20080926

• Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.

  The Journal of biological chemistry 20080926

• Vagal stimulation suppresses ischemia-induced myocardial interstitial myoglobin release.

  Life sciences 20080926

• Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening.

  Chembiochem : a European journal of chemical biology 20080922

• Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1.

  The Journal of biological chemistry 20080919

• Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway.

  Archives of biochemistry and biophysics 20080915

• Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning.

  Circulation research 20080912

• Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration.

  Experimental cell research 20080910

• Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.

  Cell 20080905

• Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.

  The Journal of clinical investigation 20080902

• Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts.

  Basic research in cardiology 20080901

• Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate.

  Molecular pharmacology 20080901

• Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells.

  The Journal of endocrinology 20080901

• Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes.

  The Journal of endocrinology 20080901

• The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells.

  Cell death and differentiation 20080901

• Triiodothyronine utilizes phosphatidylinositol 3-kinase pathway to activate anti-apoptotic myeloid cell leukemia-1.

  Journal of molecular endocrinology 20080901

• Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.

  Diabetes 20080901

• Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks.

  DNA repair 20080901

• Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy.

  Cancer science 20080901

• Platelet lysate stimulates wound repair of HaCaT keratinocytes.

  The British journal of dermatology 20080901

• Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes.

  Journal of neurochemistry 20080901

• Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation.

  Nature chemical biology 20080901

• Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3.

  Journal of neurochemistry 20080901

• Adriamycin induces H2AX phosphorylation in human spermatozoa.

  Asian journal of andrology 20080901

• Insulin and leptin enhance human sperm motility, acrosome reaction and nitric oxide production.

  Asian journal of andrology 20080901

• Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport.

  American journal of physiology. Renal physiology 20080901

• Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C.

  American journal of physiology. Heart and circulatory physiology 20080901

• Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways.

  Cellular and molecular life sciences : CMLS 20080901

• Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.

  Acta crystallographica. Section D, Biological crystallography 20080901

• Increased but error-prone nonhomologous end joining in immortalized lymphoblastoid cell extracts from adult cancer patients with late radionecrosis.

  International journal of radiation oncology, biology, physics 20080901

• Involvement of insulin in early development of mouse one-cell stage embryos.

  Science in China. Series C, Life sciences 20080901

• Involvement of phosphatidylinositol 4,5-bisphosphate in the desensitization of canonical transient receptor potential 5.

  Biological & pharmaceutical bulletin 20080901

• Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.

  PLoS biology 20080901

• Thrombin-stimulated proliferation of cultured human synovial fibroblasts through proteolytic activation of proteinase-activated receptor-1.

  Journal of pharmacological sciences 20080901

• Effect of chemotherapeutic stress on induction of vascular endothelial growth factor family members and receptors in human colorectal cancer cells.

  Molecular cancer therapeutics 20080901

• Regulation of cell survival and death signals induced by oxidative stress.

  Journal of clinical biochemistry and nutrition 20080901

• [Phosphoinositide 3-kinase/Akt pathway involved in regulation of hypoxia inducible factor 1alpha in hypoxia ischemia brain damage of neonatal rats].

  Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20080901

• The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion.

  Annals of the New York Academy of Sciences 20080901

• Modulation by testosterone of an endogenous hERG potassium channel current.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

• Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

• Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action.

  Biologics : targets & therapy 20080901

• The inhibition of insulin-stimulated proliferation of vascular smooth muscle cells by rosiglitazone is mediated by the Akt-mTOR-P70S6K pathway.

  Yonsei medical journal 20080830

• Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway.

  Brain research 20080828

• The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.

  Brain research 20080828

• Slow self-activation enhances the potency of viridin prodrugs.

  Journal of medicinal chemistry 20080814

• In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.

  Digestive diseases and sciences 20080801

• Microfluidic switching system for analyzing chemotaxis responses of wortmannin-inhibited HL-60 cells.

  Biomedical microdevices 20080801

• Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway.

  Journal of cellular physiology 20080801

• Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart.

  Journal of cellular and molecular medicine 20080801

• Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.

  The Journal of investigative dermatology 20080801

• Loss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C epsilon phosphorylation.

  Cardiovascular research 20080801

• The novel adipocytokine visfatin exerts direct cardioprotective effects.

  Journal of cellular and molecular medicine 20080801

• Chemotaxis of Entamoeba histolytica towards the pro-inflammatory cytokine TNF is based on PI3K signalling, cytoskeleton reorganization and the Galactose/N-acetylgalactosamine lectin activity.

  Cellular microbiology 20080801

• Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.

  Cell death and differentiation 20080801

• The effect of cationic charge on release of eosinophil mediators.

  The Journal of allergy and clinical immunology 20080801

• Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation.

  Neurochemical research 20080801

• Phosphatidylinositol 3-kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 muscle cells: involvement of atypical protein kinase C-zeta in LCFA uptake but not oxidation.

  The Journal of endocrinology 20080801

• Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation.

  Blood 20080801

• Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines.

  Autophagy 20080801

• Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.

  Diabetes 20080801

• Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts.

  Cellular signalling 20080801

• Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death.

  The Journal of biological chemistry 20080801

• Localization and trafficking of aquaporin 2 in the kidney.

  Histochemistry and cell biology 20080801

• Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway.

  Electrophoresis 20080801

• Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells.

  Molecular cancer therapeutics 20080801

• Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity.

  Current neurovascular research 20080801

• Up-regulation of gonadotropin alpha-subunit gene by phosphatidylinositol 3-kinase inhibitors in clonal gonadotroph cells.

  Neuro endocrinology letters 20080801

• Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways.

  PLoS computational biology 20080801

• Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.

  Biochemical and biophysical research communications 20080718

• Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.

  Cancer research 20080715

• Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition.

  Chemico-biological interactions 20080710

• Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase.

  European journal of pharmacology 20080707

• Hyperbaric oxygen induces placental growth factor expression in bone marrow-derived mesenchymal stem cells.

  Life sciences 20080704

• hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.

  Oncogene 20080703

• Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.

  Oncogene 20080703

• Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701

• Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning.

  Cardiovascular research 20080701

• Adenosine induces hemeoxygenase-1 expression in microglia through the activation of phosphatidylinositol 3-kinase and nuclear factor E2-related factor 2.

  Glia 20080701

• Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.

  Domestic animal endocrinology 20080701

• Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways.

  Diabetes 20080701

• Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore.

  The Journal of pharmacology and experimental therapeutics 20080701

• Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice.

  The Journal of pharmacology and experimental therapeutics 20080701

• Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes.

  The Journal of physiology 20080701

• In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.

  British journal of pharmacology 20080701

• The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanisms.

  Molecular immunology 20080701

• Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism.

  Experimental cell research 20080701

• Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells.

  Hepatology (Baltimore, Md.) 20080701

• Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase B alpha/Akt1.

  Hypertension (Dallas, Tex. : 1979) 20080701

• Inhibition of the activity of excitatory amino acid transporter 4 expressed in Xenopus oocytes after chronic exposure to ethanol.

  Alcoholism, clinical and experimental research 20080701

• Angiotensin II promotes NO production, inhibits apoptosis and enhances adhesion potential of bone marrow-derived endothelial progenitor cells.

  Cell research 20080701

• Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing.

  Investigative ophthalmology & visual science 20080701

• Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.

  Biological & pharmaceutical bulletin 20080701

• Proteomic characterization of cytoskeletal and mitochondrial class III beta-tubulin.

  Molecular cancer therapeutics 20080701

• RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication.

  PLoS pathogens 20080701

• [Adenovirus-mediated stromal cell-derived factor-1 alpha gene transfer promotes mesenchymal stem cell migration].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080701

• Possible involvement of phosphatidylinositol 3-kinase, but not protein kinase B or glycogen synthase kinase 3beta, in progesterone-induced oocyte maturation in the Japanese brown frog, Rana japonica.

  Zoological science 20080701

• [Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080701

• Suppression of zinc-induced p53 phosphorylation and p21 expression by wortmannin in A549 human pulmonary epithelial cells.

  Environmental toxicology and pharmacology 20080701

• Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase.

  The Journal of biological chemistry 20080620

• Involvement of cyclin D1/CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb2+ -induced neuronal death in cultured hippocampal neurons.

  Toxicology and applied pharmacology 20080615

• Insulin effects on cardiac Na+/Ca2+ exchanger activity: role of the cytoplasmic regulatory loop.

  The Journal of biological chemistry 20080613

• Advantages of a selective beta-isoform phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat.

  European journal of pharmacology 20080610

• The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons.

  Naunyn-Schmiedeberg's archives of pharmacology 20080601

• Protective effect of the natural product, chaetoglobosin K, on lindane- and dieldrin-induced changes in astroglia: identification of activated signaling pathways.

  Pharmaceutical research 20080601

• Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and beta-adrenoceptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20080601

• Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation.

  Journal of cellular physiology 20080601

• Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells.

  Angiogenesis 20080601

• ROS-independent preconditioning in neurons via activation of mitoK(ATP) channels by BMS-191095.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080601

• 17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.

  Journal of neural transmission (Vienna, Austria : 1996) 20080601

• Phosphatidylinositol kinases as regulators of GA-stimulated alpha-amylase secretion in barley (Hordeum vulgare).

  Physiologia plantarum 20080601

• Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601

• Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB.

  Neuropeptides 20080601

• Posttranslational activation of endothelial nitric oxide synthase attenuates carbon tetrachloride-induced hepatotoxicity in newborn rats.

  Pediatric research 20080601

• PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy.

  American journal of physiology. Gastrointestinal and liver physiology 20080601

• Reduction of phosphorylated histone H3 serine 10 and serine 28 cell cycle marker intensities after DNA damage.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20080601

• Resveratrol inhibits migration and invasion of human breast-cancer cells.

  Molecular nutrition & food research 20080601

• Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates collagen phagocytosis by human gingival fibroblasts.

  Oral microbiology and immunology 20080601

• Selective expansion of memory CD4(+) T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells.

  European journal of immunology 20080601

• Arabidopsis thaliana leaves with altered chloroplast numbers and chloroplast movement exhibit impaired adjustments to both low and high light.

  Journal of experimental botany 20080601

• Mechanisms of the lysophosphatidic acid-induced increase in [Ca(2+)](i) in skeletal muscle cells.

  Journal of cellular and molecular medicine 20080601

• Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and the PI3-kinase/AKT pathways in multiple myeloma.

  The Journal of steroid biochemistry and molecular biology 20080601

• Neuropeptide Y promotes TGF-beta1 production in RAW264.7 cells by activating PI3K pathway via Y1 receptor.

  Neuroscience bulletin 20080601

• Metabolic and mitogenic effects of IGF-II in rainbow trout (Oncorhynchus mykiss) myocytes in culture and the role of IGF-II in the PI3K/Akt and MAPK signalling pathways.

  General and comparative endocrinology 20080601

• Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells.

  General and comparative endocrinology 20080601

• Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells.

  Bioscience, biotechnology, and biochemistry 20080601

• Clearing the brain's cobwebs: the role of autophagy in neuroprotection.

  Current neuropharmacology 20080601

• Recent developments in peptide-based nucleic acid delivery.

  International journal of molecular sciences 20080601

• Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels.

  The Journal of biological chemistry 20080530

• MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation.

  Toxicology 20080521

• Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia.

  Journal of neuroscience research 20080515

• TrkA pathway(s) is involved in regulation of TRPM7 expression in hippocampal neurons subjected to ischemic-reperfusion and oxygen-glucose deprivation.

  Brain research bulletin 20080515

• Clusterin activates survival through the phosphatidylinositol 3-kinase/Akt pathway.

  The Journal of biological chemistry 20080509

• TMEM74, a lysosome and autophagosome protein, regulates autophagy.

  Biochemical and biophysical research communications 20080502

• Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation.

  The Journal of biological chemistry 20080502

• Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol.

  European journal of pain (London, England) 20080501

• Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells.

  Journal of cellular physiology 20080501

• Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt.

  Cell biology international 20080501

• Reactive oxygen species produced up- or downstream of calcium influx regulate proinflammatory mediator release from mast cells: role of NADPH oxidase and mitochondria.

  Biochimica et biophysica acta 20080501

• Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism.

  Molecular pharmacology 20080501

• Nitric oxide protects mast cells from activation-induced cell death: the role of the phosphatidylinositol-3 kinase-Akt-endothelial nitric oxide synthase pathway.

  Journal of leukocyte biology 20080501

• Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway.

  American journal of physiology. Endocrinology and metabolism 20080501

• Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide.

  Molecular immunology 20080501

• Implication of NAG-1 in synergistic induction of apoptosis by combined treatment of sodium salicylate and PI3K/MEK1/2 inhibitors in A549 human lung adenocarcinoma cells.

  Biochemical pharmacology 20080501

• Tetraspanin CD9 regulates beta 1 integrin activation and enhances cell motility to fibronectin via a PI-3 kinase-dependent pathway.

  Experimental cell research 20080501

• B cell activation regulates exosomal HLA production.

  European journal of immunology 20080501

• Insulin inhibits tumor necrosis factor-alpha induction in myocardial ischemia/reperfusion: role of Akt and endothelial nitric oxide synthase phosphorylation.

  Critical care medicine 20080501

• Repair of radiation-induced heat-labile sites is independent of DNA-PKcs, XRCC1 and PARP.

  Radiation research 20080501

• Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080501

• Inhibition of PI3K improves contractility in alpha1-adrenergically stimulated myocardium.

  Frontiers in bioscience : a journal and virtual library 20080501

• [Effects of PI3K signaling pathway on pathogenesis of ulcerative colitis].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080501

• Enhancement of vascular function mediated by insulin and insulin-like growth factor-1 following single exercise session.

  The Chinese journal of physiology 20080430

• Epigallocatechin-3-O-gallate inhibits TNFalpha-induced monocyte chemotactic protein-1 production from vascular endothelial cells.

  Life sciences 20080423

• Specific LPA receptor subtype mediation of LPA-induced hypertrophy of cardiac myocytes and involvement of Akt and NFkappaB signal pathways.

  Journal of cellular biochemistry 20080415

• Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells.

  Journal of cellular biochemistry 20080415

• Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.

  Toxicology and applied pharmacology 20080415

• Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.

  European journal of pharmacology 20080414

• Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection.

  The Journal of biological chemistry 20080411

• Decreased islet sensitivity to insulin in hamsters with dietary-induced insulin resistance.

  Life sciences 20080409

• Retinol decreases phosphatidylinositol 3-kinase activity in colon cancer cells.

  Molecular carcinogenesis 20080401

• High glucose suppresses expression of equilibrative nucleoside transporter 1 (ENT1) in rat cardiac fibroblasts through a mechanism dependent on PKC-zeta and MAP kinases.

  Journal of cellular physiology 20080401

• Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells.

  American journal of respiratory cell and molecular biology 20080401

• Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin.

  DNA and cell biology 20080401

• High glucose increases phosphocofilin via phosphorylation of LIM kinase due to Rho/Rho kinase activation in cultured pig proximal tubular epithelial cells.

  Diabetes research and clinical practice 20080401

• Dopamine inhibits basal prolactin release in pituitary lactotrophs through pertussis toxin-sensitive and -insensitive signaling pathways.

  Endocrinology 20080401

• Short-Term culture of in vitro produced bovine preimplantation embryos with insulin-like growth factor-i prevents heat shock-induced apoptosis through activation of the Phosphatidylinositol 3-Kinase/Akt pathway.

  Molecular reproduction and development 20080401

• Rac and PI3 kinase mediate endothelial cell-reactive oxygen species generation during normoxic lung ischemia.

  Antioxidants & redox signaling 20080401

• Purinergic receptor signaling regulates N-cadherin expression in primary astrocyte cultures.

  Journal of neurochemistry 20080401

• Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.

  Blood 20080401

• The high-affinity immunoglobulin E receptor (FcepsilonRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcepsilonRIbeta chain immunoreceptor tyrosine-based activation motif.

  Biochemical pharmacology 20080401

• Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells.

  American journal of physiology. Renal physiology 20080401

• High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway.

  Arteriosclerosis, thrombosis, and vascular biology 20080401

• Long-term effects of rapamycin treatment on insulin mediated phosphorylation of Akt/PKB and glycogen synthase activity.

  Experimental cell research 20080401

• UVB induces a biphasic response of HIF-1alpha in cultured human keratinocytes.

  Experimental dermatology 20080401

• PI3K is a negative regulator of IgE production.

  International immunology 20080401

• Autophagy-physiology and pathophysiology.

  Histochemistry and cell biology 20080401

• Leptin protection of salivary gland acinar cells against ethanol cytotoxicity involves Src kinase-mediated parallel activation of prostaglandin and constitutive nitric oxide synthase pathways.

  Inflammopharmacology 20080401

• Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase.

  The Journal of experimental biology 20080401

• Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis.

  Journal of immunology (Baltimore, Md. : 1950) 20080401

• Verapamil toxicity dysregulates the phosphatidylinositol 3-kinase pathway.

  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20080401

• Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE.

  Investigative ophthalmology & visual science 20080401

• Localization of Fas/CD95 into the lipid rafts on down-modulation of the phosphatidylinositol 3-kinase signaling pathway.

  Molecular cancer research : MCR 20080401

• Regulation of inhibitors of differentiation family proteins by thyroid-stimulating hormone in FRTL-5 thyroid cells.

  Journal of Korean medical science 20080401

• Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia.

  Cardiovascular journal of Africa 20080401

• Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20080401

• High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells.

  Mutation research 20080329

• Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080326

• VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis.

  Biochemistry 20080318

• Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation.

  Toxicology and applied pharmacology 20080315

• Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production.

  Journal of immunology (Baltimore, Md. : 1950) 20080315

• Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.

  Journal of medicinal chemistry 20080313

• Laminin-332 promotes the invasion of oesophageal squamous cell carcinoma via PI3K activation.

  British journal of cancer 20080311

• The involvement of phosphoinositid 3-kinase/Akt pathway in the activation of hypoxia-inducible factor-1alpha in the developing rat brain after hypoxia-ischemia.

  Brain research 20080304

• Dual mode of HMG-CoA reductase inhibition on dendritic cell invasion.

  Atherosclerosis 20080301

• Insulin signaling stimulates insulin transport by bovine aortic endothelial cells.

  Diabetes 20080301

• GM1-induced activation of phosphatidylinositol 3-kinase: involvement of Trk receptors.

  Journal of neurochemistry 20080301

• Mitogen-stimulated and rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells.

  Endocrinology 20080301

• Modulation of the expression of the pi class of glutathione S-transferase by Andrographis paniculata extracts and andrographolide.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301

• Phosphatidylinositol 3- and 4-phosphate modulate actin filament reorganization in guard cells of day flower.

  Plant, cell & environment 20080301

• Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via Rac1/c-Jun NH2-terminal kinase activation in human melanoma cells.

  The Journal of pharmacology and experimental therapeutics 20080301

• The effects of cyclooxygenase-2 expression in prostate cancer cells: modulation of response to cytotoxic agents.

  The Journal of pharmacology and experimental therapeutics 20080301

• Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis.

  Apoptosis : an international journal on programmed cell death 20080301

• Prolactin-induced production of cytokines in macrophages in vitro involves JAK/STAT and JNK MAPK pathways.

  International immunology 20080301

• ATM mediates repression of DNA end-degradation in an ATP-dependent manner.

  DNA repair 20080301

• Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells.

  Cell cycle (Georgetown, Tex.) 20080301

• Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide.

  Journal of immunology (Baltimore, Md. : 1950) 20080301

• Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells.

  Acta pharmacologica Sinica 20080301

• Activation of phosphatidylinositol-3 kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration.

  Pancreas 20080301

• Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.

  PLoS pathogens 20080301

• BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells.

  Oncogene 20080227

• Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3beta signaling in endothelial cells.

  Life sciences 20080227

• PI3K signaling effects in hypothalamic neurons mediated by estrogen.

  The Journal of comparative neurology 20080220

• Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells.

  Neuroscience letters 20080220

• Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells.

  Biochemical pharmacology 20080215

• Characterization of Rab21-positive tubular endosomes induced by PI3K inhibitors.

  Experimental cell research 20080215

• The involvement of phosphatidylinositol 3-kinase in gonadotropin-releasing hormone-induced gonadotropin alpha- and FSHbeta-subunit genes expression in clonal gonadotroph LbetaT2 cells.

  Molecular and cellular endocrinology 20080213

• Effects of tanshinone VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts.

  European journal of pharmacology 20080212

• Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling.

  Biochemistry 20080212

• Apelin reduces myocardial reperfusion injury independently of PI3K/Akt and P70S6 kinase.

  Regulatory peptides 20080207

• Sub-plasmalemmal [Ca2+]i upstroke in myocytes of the guinea-pig small intestine evoked by muscarinic stimulation: IP3R-mediated Ca2+ release induced by voltage-gated Ca2+ entry.

  Cell calcium 20080201

• TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos.

  Cell death and differentiation 20080201

• Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.

  Clinical science (London, England : 1979) 20080201

• Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK.

  Journal of neurochemistry 20080201

• Protective effect of 17beta-estradiol on ischemic acute renal failure through the PI3K/Akt/eNOS pathway.

  Kidney international 20080201

• Migration of mesenchymal cell fated to blastema is necessary for fish fin regeneration.

  Development, growth & differentiation 20080201

• Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha.

  Molecular biology of the cell 20080201

• TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K.

  Cytokine 20080201

• A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.

  EMBO reports 20080201

• Tuberin-heterozygous cell line TSC2ang1 as a model for tuberous sclerosis-associated skin lesions.

  International journal of molecular medicine 20080201

• Ethanol increases the activity of rat excitatory amino acid transporter type 4 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase.

  Alcoholism, clinical and experimental research 20080201

• Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism.

  The Journal of endocrinology 20080201

• Complex formation of p65/RelA with nuclear Akt1 for enhanced transcriptional activation of NF-kappaB.

  Biochemical and biophysical research communications 20080125

• Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.

  The Journal of biological chemistry 20080118

• Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death.

  International journal of cancer 20080115

• Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells.

  Toxicology and applied pharmacology 20080115

• Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.

  The Journal of biological chemistry 20080104

• A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells.

  Cellular and molecular neurobiology 20080101

• Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation.

  Diabetes 20080101

• The flavonoid quercetin regulates growth and gene expression in rat FRTL-5 thyroid cells.

  Endocrinology 20080101

• The GRV2/RME-8 protein of Arabidopsis functions in the late endocytic pathway and is required for vacuolar membrane flow.

  The Plant journal : for cell and molecular biology 20080101

• Effects of wortmannin on phosphorylation of PDK1, GSK3-beta, PTEN and expression of Skp2 mRNA after ischemia/reperfusion injury in the mouse kidney.

  International urology and nephrology 20080101

• Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37.

  Frontiers in bioscience : a journal and virtual library 20080101

• Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt.

  American journal of physiology. Heart and circulatory physiology 20080101

• Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons.

  Journal of neurochemistry 20080101

• Fate of a bioactive fluorescent wortmannin derivative in cells.

  Bioconjugate chemistry 20080101

• DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

  Molecular and cellular biology 20080101

• The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells.

  Neurochemistry international 20080101

• Regulation of swelling-activated Cl(-) current by angiotensin II signalling and NADPH oxidase in rabbit ventricle.

  Cardiovascular research 20080101

• Acute effectors of GLUT1 glucose transporter subcellular targeting in CIT3 mouse mammary epithelial cells.

  Pediatric research 20080101

• Pot1 and cell cycle progression cooperate in telomere length regulation.

  Nature structural & molecular biology 20080101

• Insulin activates ATP-sensitive potassium channels via phosphatidylinositol 3-kinase in cultured vascular smooth muscle cells.

  Journal of vascular research 20080101

• The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.

  European journal of heart failure 20080101

• DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.

  Cancer research 20080101

• Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.

  Molecular cancer therapeutics 20080101

• Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt.

  Journal of neuroinflammation 20080101

• Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.

  BMC molecular biology 20080101

• Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors.

  BMC cell biology 20080101

• Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

  Retrovirology 20080101

• Hitting HIV where it hides.

  Retrovirology 20080101

• Epidermal growth factor mediates spermatogonial proliferation in newt testis.

  Reproductive biology and endocrinology : RB&E 20080101

• Acquisition of cell polarity during cell cycle and oral replacement in Tetrahymena.

  The International journal of developmental biology 20080101

• Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.

  PloS one 20080101

• Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments.

  Genome biology 20080101

• Granule formation in NGF-cultured mast cells is associated with expressions of pyruvate kinase type M2 and annexin I proteins.

  International archives of allergy and immunology 20080101

• [Induction of insulin resistance induced by PI-3K inhibitor in porcine granulosa cells].

  Zhonghua fu chan ke za zhi 20080101

• Intracellular signalling by C-peptide.

  Experimental diabetes research 20080101

• Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome.

  Molecular cancer 20080101

• Mycobacterium bovis Bacillus Calmette-Guérin (BCG) stimulates IL-10 production via the PI3K/Akt and p38 MAPK pathways in human lung epithelial cells.

  Cellular immunology 20080101

• Infection of cultured human endothelial cells by Legionella pneumophila.

  PloS one 20080101

• Insulin inhibits caspase-3 activity in human renal tubular epithelial cells via the PI3-kinase/Akt pathway.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides.

  PloS one 20080101

• Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.

  PloS one 20080101

• Pancreatic insulin content regulation by the estrogen receptor ER alpha.

  PloS one 20080101

• An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles.

  BMC cell biology 20080101

• Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion.

  PloS one 20080101

• Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20080101

• Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer.

  BMC cancer 20080101

• Induction of Akt by endogenous neurosteroids and calcium sequestration in P19 derived neurons.

  Neurotoxicity research 20080101

• Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma.

  BMC cancer 20080101

• Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion.

  BMC cancer 20080101

• Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells.

  PloS one 20080101

• Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity.

  BMC cancer 20080101

• Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.

  PloS one 20080101

• Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways.

  PloS one 20080101

• Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells.

  Cancer cell international 20080101

• ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages.

  BMC immunology 20080101

• The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.

  BMC biochemistry 20080101

• Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer.

  BMC genomics 20080101

• EHDS are serine phosphoproteins: EHD1 phosphorylation is enhanced by serum stimulation.

  Cellular & molecular biology letters 20080101

• Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton.

  PloS one 20080101

• Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK.

  BMC immunology 20080101

• Molecular targeted therapies for breast cancer treatment.

  Breast cancer research : BCR 20080101

• Deficiency in lysosomal enzyme secretion is associated with upregulation of phosphatidylinositol 4-phosphate in tetrahymena.

  The Journal of eukaryotic microbiology 20080101

• K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis.

  PloS one 20080101

• Signaling pathways required for macrophage scavenger receptor-mediated phagocytosis: analysis by scanning cytometry.

  Respiratory research 20080101

• Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity.

  Vascular pharmacology 20080101

• Phosphatidylinositol-3-kinase regulates mast cell ion channel activity.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cells.

  BMC cell biology 20080101

• Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome.

  Molecular cancer 20080101

• Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineage.

  BMC research notes 20080101

• Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase.

  PloS one 20080101

• TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells.

  BMC cancer 20080101

• Soluble bacterial constituents down-regulate secretion of IL-12 in response to intact Gram-positive bacteria.

  Microbes and infection 20080101

• Protein kinase C- and reactive oxygen species-dependent stimulation of intracellular cAMP in human eosinophils. The role of extracellular signal-regulated protein kinases.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

• Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.

  PloS one 20080101

• Genes of the most conserved WOX clade in plants affect root and flower development in Arabidopsis.

  BMC evolutionary biology 20080101

• Anti-EGFR antibody efficiently and specifically inhibits human TSC2-/- smooth muscle cell proliferation. Possible treatment options for TSC and LAM.

  PloS one 20080101

• Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5.

  BMC cancer 20080101

• Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

  PloS one 20080101

• Possible involvement of phosphatidylinositol kinases in the effect of the oxidized glutathione and glutoxim on the intracellular Ca2+ concentration in macrophages.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20080101

• Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.

  PloS one 20080101

• SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload.

  PloS one 20080101

• [The role of phosphoinositide-3-kinase in controlling the shape and directional movement in Physarum polycephalum plasmodium].

  Biofizika 20080101

• Suppressive effect of hydroquinone, a benzene metabolite, on in vitro inflammatory responses mediated by macrophages, monocytes, and lymphocytes.

  Mediators of inflammation 20080101

• Methods to investigate autophagy during starvation and regeneration in hydra.

  Methods in enzymology 20080101

• Simvastatin attenuates cerebral vasospasm and improves outcomes by upregulation of PI3K/Akt pathway in a rat model of subarachnoid hemorrhage.

  Acta neurochirurgica. Supplement 20080101

• Cellular Ser/Thr-kinase assays using generic peptide substrates.

  Current chemical genomics 20080101

• Synergistic induction of CX3CL1 by TNF alpha and IFN gamma in osteoblasts from rheumatoid arthritis: involvement of NF-kappa B and STAT-1 signaling pathways.

  Journal of inflammation research 20080101

• Apoptosis and autophagy as mechanisms of dinoflagellate symbiont release during cnidarian bleaching: every which way you lose.

  Proceedings. Biological sciences 20071222

• Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform.

  Blood 20071215

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro.

  Biochemical pharmacology 20071215

• Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

  Bioorganic & medicinal chemistry 20071215

• A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments.

  Biochemical and biophysical research communications 20071207

• Vasoactive intestinal peptide (VIP) increases vascular endothelial growth factor (VEGF) expression and secretion in human breast cancer cells.

  Regulatory peptides 20071204

• Insulin attenuates apoptosis and exerts anti-inflammatory effects in endotoxemic human macrophages.

  The Journal of surgical research 20071201

• Serotonin stimulates mouse skeletal muscle 6-phosphofructo-1-kinase through tyrosine-phosphorylation of the enzyme altering its intracellular localization.

  Molecular genetics and metabolism 20071201

• The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms.

  The Journal of clinical endocrinology and metabolism 20071201

• Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal.

  Cellular signalling 20071201

• Effect of dehydroepiandrosterone on insulin sensitivity in Otsuka Long-Evans Tokushima-fatty rats.

  Acta diabetologica 20071201

• Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

  Cellular signalling 20071201

• Serum and forskolin cooperate to promote G1 progression in Schwann cells by differentially regulating cyclin D1, cyclin E1, and p27Kip expression.

  Glia 20071201

• Modulation of dendritic cell differentiation by colony-stimulating factor-1: role of phosphatidylinositol 3'-kinase and delayed caspase activation.

  Journal of leukocyte biology 20071201

• HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.

  American journal of physiology. Endocrinology and metabolism 20071201

• Endothelial PI 3-kinase activity regulates lymphocyte diapedesis.

  American journal of physiology. Heart and circulatory physiology 20071201

• Cell cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during aging.

  American journal of physiology. Gastrointestinal and liver physiology 20071201

• Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells.

  Journal of molecular and cellular cardiology 20071201

• Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population.

  Oncology reports 20071201

• Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol 3-kinase (PI3K) pathway.

  Biological chemistry 20071201

• TNF-alpha is secreted by monocytes in transit to become macrophages, but not by peripheral blood monocytes, following OK-432 (lyophilized S. pyogenes) stimulation.

  Scandinavian journal of immunology 20071201

• Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo.

  Journal of immunology (Baltimore, Md. : 1950) 20071201

• Neuroprotection by sodium ferulate against glutamate-induced apoptosis is mediated by ERK and PI3 kinase pathways.

  Acta pharmacologica Sinica 20071201

• Effects of chronic exercise on endothelial dysfunction and insulin signaling of cutaneous microvascular in streptozotocin-induced diabetic rats.

  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20071201

• Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin.

  Growth factors (Chur, Switzerland) 20071201

• NBD-conjugated biosurfactant (MEL-A) shows a new pathway for transfection.

  Journal of controlled release : official journal of the Controlled Release Society 20071120

• Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation.

  Experimental cell research 20071115

• PTEN down-regulates IL-17 expression in a murine model of toluene diisocyanate-induced airway disease.

  Journal of immunology (Baltimore, Md. : 1950) 20071115

• Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20071107

• Complement receptor type 3 (CR3)- and Fc receptor (FcR)-mediated matrix metalloproteinase 9 (MMP-9) secretion and their intracellular signalling of bovine neutrophils.

  Veterinary research communications 20071101

• Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport.

  Atherosclerosis 20071101

• Low levels of DNA ligases III and IV sufficient for effective NHEJ.

  Journal of cellular physiology 20071101

• Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes.

  The Journal of investigative dermatology 20071101

• Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.

  Biology of reproduction 20071101

• Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.

  Blood 20071101

• Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue.

  The Journal of clinical endocrinology and metabolism 20071101

• The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat.

  Arteriosclerosis, thrombosis, and vascular biology 20071101

• Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases.

  Molecular and cellular neurosciences 20071101

• Signaling molecules involved in production and regulation of IL-1beta by murine peritoneal macrophages in vitro on treatment with concanavalin A.

  International immunopharmacology 20071101

• PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways.

  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20071101

• Chronic high blood flow potentiates shear stress-induced release of NO in arteries of aged rats.

  American journal of physiology. Heart and circulatory physiology 20071101

• Activation of telomerase by ionizing radiation: differential response to the inhibition of DNA double-strand break repair by abrogation of poly (ADP-ribosyl)ation, by LY294002, or by Wortmannin.

  International journal of radiation oncology, biology, physics 20071101

• Resistin, an adipocytokine, offers protection against acute myocardial infarction.

  Journal of molecular and cellular cardiology 20071101

• Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors.

  International journal of oncology 20071101

• The metabolism of serotonin in neuronal cells in culture and platelets.

  Experimental brain research 20071101

• Leptin stimulates alpha1(I) collagen expression in human hepatic stellate cells via the phosphatidylinositol 3-kinase/Akt signalling pathway.

  Liver international : official journal of the International Association for the Study of the Liver 20071101

• Rac2 GTPase activation by angiotensin II is modulated by Ca2+/calcineurin and mitogen-activated protein kinases in human neutrophils.

  Journal of molecular endocrinology 20071101

• Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes.

  Biological & pharmaceutical bulletin 20071101

• Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT.

  Molecular cancer therapeutics 20071101

• Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation.

  European journal of pharmacology 20071031

• Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes.

  Life sciences 20071027

• Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.

  The Journal of biological chemistry 20071012

• Mixed polymeric micelles for combination cancer chemotherapy through the concurrent delivery of multiple chemotherapeutic agents.

  Journal of controlled release : official journal of the Controlled Release Society 20071008

• Trifluoperazine stimulates ionizing radiation induced cell killing through inhibition of DNA repair.

  Mutation research 20071004

• Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro.

  Journal of cellular biochemistry 20071001

• PIP(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP(2) depletion by Gq-coupled receptors in single living neurons.

  Pflugers Archiv : European journal of physiology 20071001

• Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells.

  Journal of cellular physiology 20071001

• Regulation of interleukin-8 expression in human prostate cancer cells by insulin-like growth factor-I and inflammatory cytokines.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20071001

• Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis.

  Molecular and cellular biochemistry 20071001

• Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C.

  Pflugers Archiv : European journal of physiology 20071001

• The Akt/GSK-3beta axis as a new signaling pathway of the histamine H(3) receptor.

  Journal of neurochemistry 20071001

• The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation.

  Cardiovascular research 20071001

• Activation of calcium-dependent kinases and epidermal growth factor receptor regulate muscarinic acetylcholine receptor-mediated MAPK/ERK activation in thyroid epithelial cells.

  Cellular signalling 20071001

• Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis.

  Traffic (Copenhagen, Denmark) 20071001

• Human sperm express a functional androgen receptor: effects on PI3K/AKT pathway.

  Human reproduction (Oxford, England) 20071001

• Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.

  Journal of leukocyte biology 20071001

• Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1{alpha} and airway responsiveness to ACh.

  American journal of physiology. Lung cellular and molecular physiology 20071001

• EV71 induces VCAM-1 expression via PDGF receptor, PI3-K/Akt, p38 MAPK, JNK and NF-kappaB in vascular smooth muscle cells.

  Cellular signalling 20071001

• Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli.

  European journal of immunology 20071001

• Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20071001

• Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn.

  American journal of reproductive immunology (New York, N.Y. : 1989) 20071001

• Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.

  Nature cell biology 20071001

• Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models.

  Pancreas 20071001

• Photodynamic therapy induces caspase-dependent apoptosis in rat CNV model.

  Investigative ophthalmology & visual science 20071001

• Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.

  PLoS medicine 20071001

• Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations.

  Radiation medicine 20071001

• Neuronal chemokines: versatile messengers in central nervous system cell interaction.

  Molecular neurobiology 20071001

• Suppression of phosphoenolpyruvate carboxykinase gene expression by reduced endogenous glutathione level.

  Biochimica et biophysica acta 20071001

• Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics.

  PLoS medicine 20071001

• The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation.

  Vascular health and risk management 20071001

• Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k-Akt signaling pathway.

  Cancer letters 20070918

• Resveratrol is a class IA phosphoinositide 3-kinase inhibitor.

  The Biochemical journal 20070915

• Insulin inhibition of apolipoprotein B mRNA translation is mediated via the PI-3 kinase/mTOR signaling cascade but does not involve internal ribosomal entry site (IRES) initiation.

  Archives of biochemistry and biophysics 20070915

• Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia.

  Journal of immunology (Baltimore, Md. : 1950) 20070915

• Dual inhibition of PI3K/Akt signaling and the DNA damage checkpoint in p53-deficient cells with strong survival signaling: implications for cancer therapy.

  Cell cycle (Georgetown, Tex.) 20070915

• Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.

  Journal of medicinal chemistry 20070906

• Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines.

  Journal of cellular biochemistry 20070901

• Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes.

  Molecular and cellular biochemistry 20070901

• Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism.

  Apoptosis : an international journal on programmed cell death 20070901

• Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK.

  American journal of physiology. Endocrinology and metabolism 20070901

• IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.

  Journal of cellular physiology 20070901

• Cyclic pressure stimulates DNA synthesis through the PI3K/Akt signaling pathway in rat bladder smooth muscle cells.

  Annals of biomedical engineering 20070901

• Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells.

  American journal of physiology. Endocrinology and metabolism 20070901

• Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione.

  American journal of respiratory cell and molecular biology 20070901

• R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1.

  American journal of physiology. Endocrinology and metabolism 20070901

• Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase C.

  American journal of physiology. Renal physiology 20070901

• Modulatory role of phosphoinositide 3-kinase in gastric acid secretion.

  American journal of physiology. Gastrointestinal and liver physiology 20070901

• Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

  Molecular endocrinology (Baltimore, Md.) 20070901

• Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway.

  Journal of leukocyte biology 20070901

• Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293 cells.

  British journal of pharmacology 20070901

• Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells.

  Diabetologia 20070901

• Protein kinase C-dependent antilipolysis by insulin in rat adipocytes.

  Biochimica et biophysica acta 20070901

• Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.

  Anesthesia and analgesia 20070901

• A platelet biomarker for assessing phosphoinositide 3-kinase inhibition during cancer chemotherapy.

  Molecular cancer therapeutics 20070901

• The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.

  Molecular cancer therapeutics 20070901

• Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells.

  Biological & pharmaceutical bulletin 20070901

• Signal transduction mechanisms of CD137 ligand in human monocytes.

  Cellular signalling 20070901

• Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway.

  Journal of cardiovascular pharmacology 20070901

• Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.

  Journal of pharmacological sciences 20070901

• Potentiating effect of an endocrine disruptor, paranonylphenol, on the generation of reactive oxygen species (ROS) in human venous blood -- association with the activation of signal transduction pathway.

  Journal of UOEH 20070901

• Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.

  PLoS pathogens 20070901

• The molecular genetics of breast cancer and targeted therapy.

  Biologics : targets & therapy 20070901

• Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.

  Biochemistry 20070821

• Identification of S6K2 as a centrosome-located kinase.

  FEBS letters 20070821

• Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.

  Oncogene 20070816

• Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

  Oncogene 20070816

• Furanosteroid studies. Stereoselective synthesis of the A,B,E-ring core of wortmannin.

  Organic letters 20070816

• Different signaling pathways utilized by insulin to regulate the expression of ENT2, CNT1, CNT2 nucleoside transporters in rat cardiac fibroblasts.

  Archives of biochemistry and biophysics 20070815

• Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance.

  Experimental cell research 20070815

• IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway.

  Glia 20070815

• Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.

  Molecular and cellular endocrinology 20070815

• Improved poststorage cardiac function by poly (ADP-ribose) polymerase inhibition: role of phosphatidylinositol 3-kinase Akt pathway.

  Transplantation 20070815

• Upregulation of amyloid precursor protein by platelet-derived growth factor in hippocampal precursor cells.

  Neuroreport 20070806

• Phosphatidylinositol 3-kinase pathway regulates sperm viability but not capacitation on boar spermatozoa.

  Molecular reproduction and development 20070801

• Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes.

  Cellular signalling 20070801

• Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells.

  Pharmaceutical research 20070801

• Regulation of M(Kv7.2/7.3) channels in neurons by PIP(2) and products of PIP(2) hydrolysis: significance for receptor-mediated inhibition.

  The Journal of physiology 20070801

• Possible roles of neuropeptide Y Y3-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction.

  American journal of physiology. Heart and circulatory physiology 20070801

• Down-regulation of GRK2 after oxygen and glucose deprivation in rat hippocampal slices: role of the PI3-kinase pathway.

  Journal of neurochemistry 20070801

• NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin.

  Cellular signalling 20070801

• Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain.

  Journal of neurochemistry 20070801

• Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20070801

• Role of PI3-kinase and PI4-kinase in actin polymerization during bovine sperm capacitation.

  Biology of reproduction 20070801

• Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.

  American journal of physiology. Heart and circulatory physiology 20070801

• Homocysteine-induced biochemical stress predisposes to cytoskeletal remodeling in stretched endothelial cells.

  Molecular and cellular biochemistry 20070801

• Localization of intracellular compartments that exchange Na,K-ATPase molecules with the plasma membrane in a hormone-dependent manner.

  British journal of pharmacology 20070801

• Dual control of cardiac Na+ Ca2+ exchange by PIP(2): analysis of the surface membrane fraction by extracellular cysteine PEGylation.

  The Journal of physiology 20070801

• Dual control of cardiac Na+ Ca2+ exchange by PIP(2): electrophysiological analysis of direct and indirect mechanisms.

  The Journal of physiology 20070801

• Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors.

  Human reproduction (Oxford, England) 20070801

• Dimethyl sulphoxide relaxes rabbit detrusor muscle by decreasing the Ca2+ sensitivity of the contractile apparatus.

  British journal of pharmacology 20070801

• Interferon-gamma attenuates the survival activity of G-CSF through PI3K/Akt signaling pathway in mouse multipotent progenitor cells.

  Annals of hematology 20070801

• Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow.

  American journal of physiology. Gastrointestinal and liver physiology 20070801

• 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition.

  International journal of oncology 20070801

• Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.

  International journal of oncology 20070801

• Leptin promotes rapid dynamic changes in hippocampal dendritic morphology.

  Molecular and cellular neurosciences 20070801

• Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats.

  Experimental neurology 20070801

• Plasminogen gene expression is regulated by nerve growth factor.

  Journal of thrombosis and haemostasis : JTH 20070801

• A logical model provides insights into T cell receptor signaling.

  PLoS computational biology 20070801

• The phytoestrogen ginsensoside Re activates potassium channels of vascular smooth muscle cells through PI3K/Akt and nitric oxide pathways.

  The journal of medical investigation : JMI 20070801

• The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.

  Current genomics 20070801

• Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy.

  FEBS letters 20070724

• Calcium ionophore-induced egress of Toxoplasma gondii shortly after host cell invasion.

  Veterinary parasitology 20070720

• The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells.

  Biochemical pharmacology 20070715

• Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors.

  Experimental cell research 20070715

• Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia.

  Journal of immunology (Baltimore, Md. : 1950) 20070715

• Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.

  The Journal of biological chemistry 20070713

• Persistent Cdk2 inactivation drives growth arrest of BCR-ABL-expressing cells in response to dual inhibitor of SRC and ABL kinases SKI606.

  Leukemia research 20070701

• Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway.

  Journal of neurochemistry 20070701

• Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells.

  Cellular signalling 20070701

• Nongenomic, endothelium-independent effects of estrogen on human coronary smooth muscle are mediated by type I (neuronal) NOS and PI3-kinase-Akt signaling.

  American journal of physiology. Heart and circulatory physiology 20070701

• PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1.

  Journal of cellular biochemistry 20070701

• The acute phase protein alpha2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1,2 and PI3-kinase/Akt pathways.

  Cardiovascular research 20070701

• Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity.

  Endocrinology 20070701

• Thrombin potently enhances swelling-sensitive glutamate efflux from cultured astrocytes.

  Glia 20070701

• GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion.

  Basic research in cardiology 20070701

• SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts.

  Basic research in cardiology 20070701

• Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway.

  British journal of pharmacology 20070701

• Prolactin-stimulated transepithelial calcium transport in duodenum and Caco-2 monolayer are mediated by the phosphoinositide 3-kinase pathway.

  American journal of physiology. Endocrinology and metabolism 20070701

• Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• Phosphatidylinositol 4-kinase activation is an early response to salicylic acid in Arabidopsis suspension cells.

  Plant physiology 20070701

• Peptide degradation is a critical determinant for cell-penetrating peptide uptake.

  Biochimica et biophysica acta 20070701

• Induction of phosphatidylinositol 3-kinase-mediated endocytosis by salt stress leads to intracellular production of reactive oxygen species and salt tolerance.

  The Plant journal : for cell and molecular biology 20070701

• Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells.

  The FEBS journal 20070701

• Mechanisms of kringle fragment of urokinase-induced vascular smooth muscle cell migration.

  The Journal of surgical research 20070701

• Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc gamma receptor ligation in murine macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20070701

• IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.

  The Journal of endocrinology 20070701

• Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt.

  Arthritis and rheumatism 20070701

• 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells.

  Biological & pharmaceutical bulletin 20070701

• Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.

  PLoS pathogens 20070701

• [The advantages for Snail expression to promote cell migration and induce actin reorganization and to protect against the serum-deprivation-triggered apoptosis of bone marrow stem cells].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20070701

• SNX1 and SNX2 mediate retrograde transport of Shiga toxin.

  Biochemical and biophysical research communications 20070629

• Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.

  Journal of agricultural and food chemistry 20070627

• [Local shRNA modulation of phosphatidylinositol 3-kinase signaling pathway reduces intimal hyperplasia in vein grafts: experiment with rats].

  Zhonghua yi xue za zhi 20070626

• Calyculin A stimulates the expression of TNF-alpha mRNA via phosphorylation of Akt in mouse osteoblastic MC3T3-E1 cells.

  Molecular and cellular endocrinology 20070615

• Age-related nonhomologous end joining activity in rat neurons.

  Brain research bulletin 20070615

• YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.

  Oncogene 20070607

• Akt up- and down-regulation in response to endoplasmic reticulum stress.

  Brain research 20070604

• Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events.

  Molecular and cellular biochemistry 20070601

• Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

  American journal of physiology. Heart and circulatory physiology 20070601

• The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.

  American journal of physiology. Endocrinology and metabolism 20070601

• Endothelium-derived nitric oxide mediates the antiadrenergic effect of human vasostatin-1 in rat ventricular myocardium.

  American journal of physiology. Heart and circulatory physiology 20070601

• Translocation of enteropathogenic Escherichia coli across an in vitro M cell model is regulated by its type III secretion system.

  Cellular microbiology 20070601

• Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells.

  Journal of cellular physiology 20070601

• FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070601

• Pancreatic glucokinase is activated by insulin-like growth factor-I.

  Endocrinology 20070601

• Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB.

  The Biochemical journal 20070601

• Phosphatase and tensin homolog deleted on chromosome 10 suppression is an important process in peroxisome proliferator-activated receptor-gamma signaling in adipocytes and myotubes.

  Molecular pharmacology 20070601

• Plasma membrane delivery, endocytosis and turnover of transcobalamin receptor in polarized human intestinal epithelial cells.

  The Journal of physiology 20070601

• Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling.

  Molecular & cellular proteomics : MCP 20070601

• Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment.

  The British journal of dermatology 20070601

• Regulation of scavenger receptor class BI gene expression by angiotensin II in vascular endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20070601

• Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.

  Neuropharmacology 20070601

• DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation.

  Cancer science 20070601

• Acute regulation of the epithelial Na+ channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells.

  Journal of the American Society of Nephrology : JASN 20070601

• Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin.

  Biochimica et biophysica acta 20070601

• Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3.

  Journal of immunology (Baltimore, Md. : 1950) 20070601

• Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism.

  Journal of immunology (Baltimore, Md. : 1950) 20070601

• Wear particles generated from studded tires and pavement induces inflammatory reactions in mouse macrophage cells.

  Chemical research in toxicology 20070601

• The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage.

  Annals of surgery 20070601

• Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes.

  The American journal of pathology 20070601

• [Effect of wortmannin on rejoining of telomeric DNA strand breaks].

  Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20070601

• Induction of neurite outgrowth in PC12 cells by the medium-chain fatty acid octanoic acid.

  Neuroscience 20070525

• Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070516

• Curcumin-induced GADD153 upregulation: modulation by glutathione.

  Journal of cellular biochemistry 20070515

• Exploring the specificity of the PI3K family inhibitor LY294002.

  The Biochemical journal 20070515

• Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms.

  Biochemical pharmacology 20070515

• Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.

  The Journal of biological chemistry 20070511

• Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells.

  Biochemical and biophysical research communications 20070511

• Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1.

  Cancer letters 20070508

• Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.

  The Journal of biological chemistry 20070504

• Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.

  Biochemical and biophysical research communications 20070504

• Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin.

  Regulatory peptides 20070503

• The PPAR-gamma agonist pioglitazone increases neoangiogenesis and prevents apoptosis of endothelial progenitor cells.

  Atherosclerosis 20070501

• Hydrogen peroxide production is an early event during bicarbonate induced stomatal closure in abaxial epidermis of Arabidopsis.

  Planta 20070501

• Activation of the S phase DNA damage checkpoint by mitomycin C.

  Journal of cellular physiology 20070501

• P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells.

  Cellular signalling 20070501

• Chronic preconditioning: a novel approach for cardiac protection.

  American journal of physiology. Heart and circulatory physiology 20070501

• Cyclooxygenase-2-derived prostaglandin e2 protects mouse embryonic stem cells from apoptosis.

  Stem cells (Dayton, Ohio) 20070501

• Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway.

  Endocrinology 20070501

• Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.

  Gynecologic oncology 20070501

• Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes.

  The Biochemical journal 20070501

• Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells.

  Biochemical pharmacology 20070501

• Nongenomic estrogen effects on nitric oxide synthase activity in rat adipocytes.

  Endocrinology 20070501

• Insulin increases the potency of glycine at ionotropic glycine receptors.

  Molecular pharmacology 20070501

• Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling.

  Biochimie 20070501

• PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors.

  Molecular human reproduction 20070501

• Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival.

  Cancer biology & therapy 20070501

• Enhanced susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in oral squamous cell carcinoma cells treated with phosphatidylinositol 3-kinase inhibitors.

  International journal of oncology 20070501

• Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver.

  Liver international : official journal of the International Association for the Study of the Liver 20070501

• Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development.

  The Journal of pathology 20070501

• Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus.

  Steroids 20070501

• Enhancement of tumor radioresponse by wortmannin in C3H/HeJ hepatocarcinoma.

  Journal of radiation research 20070501

• Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation.

  Allergy 20070501

• The role of cargo proteins in GGA recruitment.

  Traffic (Copenhagen, Denmark) 20070501

• Progesterone reduces the migration of mast cells toward the chemokine stromal cell-derived factor-1/CXCL12 with an accompanying decrease in CXCR4 receptors.

  American journal of physiology. Endocrinology and metabolism 20070501

• Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070501

• Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells.

  Molecules and cells 20070430

• Hydroquinone, a reactive metabolite of benzene, reduces macrophage-mediated immune responses.

  Molecules and cells 20070430

• Activation of LFA-1 by ionomycin is independent of calpain-mediated talin cleavage.

  Biochemical and biophysical research communications 20070427

• Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/ligase IV.

  The Journal of biological chemistry 20070420

• Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus.

  The Journal of physiology 20070415

• Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis.

  Glia 20070415

• A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity.

  Journal of immunology (Baltimore, Md. : 1950) 20070415

• CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway.

  Biochemical and biophysical research communications 20070413

• Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells.

  European journal of pharmacology 20070410

• A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells.

  Life sciences 20070410

• Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats.

  Life sciences 20070410

• Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor.

  Life sciences 20070410

• AKT mediates the pro-survival effects of KIT in ovarian cancer cells and is a determinant of sensitivity to imatinib mesylate.

  Gynecologic oncology 20070401

• Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070401

• Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20070401

• Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms.

  Journal of cellular physiology 20070401

• Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin.

  Endocrinology 20070401

• IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.

  American journal of physiology. Gastrointestinal and liver physiology 20070401

• Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation.

  Journal of leukocyte biology 20070401

• A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling.

  The Biochemical journal 20070401

• Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKCalpha and the MAPK/ERK cascade.

  Journal of lipid research 20070401

• Ezrin/moesin in motile Walker 256 carcinosarcoma cells: signal-dependent relocalization and role in migration.

  Experimental cell research 20070401

• Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways.

  Journal of molecular and cellular cardiology 20070401

• Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway.

  Toxicology and applied pharmacology 20070401

• CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment.

  International immunology 20070401

• Insulinomimetic Zn complex (Zn(opt)2) enhances insulin signaling pathway in 3T3-L1 adipocytes.

  Journal of inorganic biochemistry 20070401

• In vitro actions of insulin-like growth factor-I on ovarian follicle maturation in white perch (Morone americana).

  General and comparative endocrinology 20070401

• Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts.

  Biochimica et biophysica acta 20070401

• Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1.

  Molecular and cellular neurosciences 20070401

• Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells.

  International journal of oncology 20070401

• Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

  Nature chemical biology 20070401

• Upregulation of IGF-I in the goldfish retinal ganglion cells during the early stage of optic nerve regeneration.

  Neurochemistry international 20070401

• The role of class I phosphoinositide 3-kinase in T-cell function and autoimmunity.

  Biochemical Society transactions 20070401

• Role of class II phosphoinositide 3-kinase in cell signalling.

  Biochemical Society transactions 20070401

• Glucose transporter expression on the plasma membrane of resting and activated white blood cells.

  European journal of clinical investigation 20070401

• Calpain inhibition impairs glycogen syntheses in HepG2 hepatoma cells without altering insulin signaling.

  The Journal of endocrinology 20070401

• Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.

  Journal of pharmacological sciences 20070401

• Glucose transport in human peripheral blood lymphocytes influenced by type 2 diabetes mellitus.

  Archivum immunologiae et therapiae experimentalis 20070401

• Bradykinin induced sustained anti-adrenergic actions in guinea pig heart muscle involves PKC.

  Scandinavian cardiovascular journal : SCJ 20070401

• Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells.

  Biochimica et biophysica acta 20070401

• Participation of phosphatidyl inositol 3-kinase/protein kinase B and ERK1/2 pathways in interleukin-1beta stimulation of lactate production in Sertoli cells.

  Reproduction (Cambridge, England) 20070401

• IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.

  Molecular and cellular endocrinology 20070330

• Insulin induces a transcriptional activation of epiregulin, HB-EGF and amphiregulin, by a PI3K-dependent mechanism: identification of a specific insulin-responsive promoter element.

  Biochemical and biophysical research communications 20070323

• Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells.

  Biochemical and biophysical research communications 20070323

• AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.

  Biochemical and biophysical research communications 20070323

• Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.

  Molecular and cellular endocrinology 20070315

• Hepatocyte growth factor (HGF) enhances cardiac commitment of differentiating embryonic stem cells by activating PI3 kinase.

  Experimental cell research 20070310

• AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.

  The Journal of biological chemistry 20070309

• Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells.

  Circulation research 20070302

• Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53.

  Cell death and differentiation 20070301

• Functional characterization of AATF transcriptome in human leukemic cells.

  Molecular and cellular biochemistry 20070301

• PI3-kinase-dependent electrogenic intestinal transport of glucose and amino acids.

  Pflugers Archiv : European journal of physiology 20070301

• Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells.

  American journal of physiology. Endocrinology and metabolism 20070301

• Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo.

  American journal of physiology. Endocrinology and metabolism 20070301

• Cofilin plays a critical role in IL-8-dependent chemotaxis of neutrophilic HL-60 cells through changes in phosphorylation.

  Journal of leukocyte biology 20070301

• Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells.

  American journal of physiology. Gastrointestinal and liver physiology 20070301

• TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20070301

• Increased insulin-stimulated expression of arterial angiotensinogen and angiotensin type 1 receptor in patients with type 2 diabetes mellitus and atheroma.

  Arteriosclerosis, thrombosis, and vascular biology 20070301

• Phosphatidylinositol 3'-kinase is a critical mediator of interferon-gamma-induced increases in enteric epithelial permeability.

  The Journal of pharmacology and experimental therapeutics 20070301

• Melanocortin-3 receptor activates MAP kinase via PI3 kinase.

  Regulatory peptides 20070301

• Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.

  Leukemia 20070301

• Insulin augments matrix metalloproteinase-9 expression in monocytes.

  Cardiovascular research 20070301

• Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex.

  Human molecular genetics 20070301

• De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1.

  International journal of molecular medicine 20070301

• Berberine stimulates glucose transport through a mechanism distinct from insulin.

  Metabolism: clinical and experimental 20070301

• Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins.

  Journal of molecular and cellular cardiology 20070301

• Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.

  Traffic (Copenhagen, Denmark) 20070301

• Mechanism of Na+/Ca2+ exchanger activation by hydrogen peroxide in guinea-pig ventricular myocytes.

  Journal of pharmacological sciences 20070301

• IGF-I-induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK, and Src-like tyrosine kinases.

  Journal of neurochemistry 20070301

• Structural and functional diversity of the microbial kinome.

  PLoS biology 20070301

• Covalent reactions of wortmannin under physiological conditions.

  Chemistry & biology 20070301

• The protective effect of interleukin-11 on the cell death induced by X-ray irradiation in cultured intestinal epithelial cell.

  Journal of radiation research 20070301

• [Protein kinase B inhibitor enhance sensitivity of gastric cancer cell to etoposide].

  Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20070301

• Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301

• Insulin enhances nitric oxide production in trabecular meshwork cells via de novo pathway for tetrahydrobiopterin synthesis.

  Korean journal of ophthalmology : KJO 20070301

• Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells.

  Journal of controlled release : official journal of the Controlled Release Society 20070226

• Nitric oxide stimulates insulin gene transcription in pancreatic beta-cells.

  Biochemical and biophysical research communications 20070223

• Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor.

  Biochemical and biophysical research communications 20070216

• Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20070215

• Mechanisms of co-modified liver-targeting liposomes as gene delivery carriers based on cellular uptake and antigens inhibition effect.

  Journal of controlled release : official journal of the Controlled Release Society 20070212

• Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor.

  Cancer letters 20070208

• [Expression of phosphatidylinositol 3-kinase and effects of wortmannin on the expression of tumor necrosis factor-alpha in ulcerative colitis].

  Zhonghua yi xue za zhi 20070206

• Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells.

  European journal of pharmacology 20070205

• Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurity.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20070201

• Phosphatidylinositol 3-kinase-mediated regulation of IL-10 and IL-12 production in macrophages stimulated with CpG oligodeoxynucleotide.

  Molecular immunology 20070201

• Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin.

  American journal of physiology. Renal physiology 20070201

• ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart.

  American journal of physiology. Heart and circulatory physiology 20070201

• Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells.

  Bone 20070201

• Crucial role of cytoskeleton reorganization in the negative inotropic effect of chromogranin A-derived peptides in eel and frog hearts.

  Regulatory peptides 20070201

• Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells.

  Gynecologic oncology 20070201

• Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways.

  Journal of lipid research 20070201

• Vasopressin stimulates Na-dependent phosphate transport and calcification in rat aortic smooth muscle cells.

  Endocrine journal 20070201

• Intermittent hypoxia-induced delayed cardioprotection is mediated by PKC and triggered by p38 MAP kinase and Erk1/2.

  Journal of molecular and cellular cardiology 20070201

• Role of PI3-K/Akt pathway and its effect on glial cell line-derived neurotrophic factor in midbrain dopamine cells.

  Acta pharmacologica Sinica 20070201

• Pathway-specific effect of caffeine on protection against UV irradiation-induced apoptosis in corneal epithelial cells.

  Investigative ophthalmology & visual science 20070201

• Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFbeta1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells.

  The Journal of endocrinology 20070201

• [Internalizing to control , or how endocytosis regulates auxin flux in plants].

  Medecine sciences : M/S 20070201

• Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells.

  Molecular cancer therapeutics 20070201

• Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20070201

• MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling.

  The Journal of biological chemistry 20070126

• Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects.

  The Journal of biological chemistry 20070126

• The involvement of phosphatidylinositol 3-kinase /Akt signaling in high glucose-induced downregulation of GLUT-1 expression in ARPE cells.

  Life sciences 20070123

• Involvement of phosphatidylinositol-3-kinase and ERK pathways in the production of TGF-beta1 by macrophages treated with liposomes composed of phosphatidylserine.

  FEBS letters 20070123

• Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS.

  Cardiovascular research 20070115

• Inhibition of myosin light-chain phosphorylation inverts the birefringence response of porcine airway smooth muscle.

  The Journal of physiology 20070115

• Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.

  Toxicology and applied pharmacology 20070115

• The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase.

  Journal of immunology (Baltimore, Md. : 1950) 20070115

• H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A.

  Life sciences 20070109

• Activation of protein kinase B/Akt in the periphery contributes to pain behavior induced by capsaicin in rats.

  Neuroscience 20070105

• Nitric oxide-dependent vasodilatation by ethanolic extract of Hancornia speciosa via phosphatidyl-inositol 3-kinase.

  Journal of ethnopharmacology 20070103

• Altered insulin-mediated and insulin-like growth factor-1-mediated vasorelaxation in aortas of obese Zucker rats.

  International journal of obesity (2005) 20070101

• Specific inhibitors of mitogen-activated protein kinase and PI3-K pathways impair immune responses by hemocytes of trematode intermediate host snails.

  Developmental and comparative immunology 20070101

• GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3.

  Cellular signalling 20070101

• Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20070101

• Regulation of human cone cyclic nucleotide-gated channels by endogenous phospholipids and exogenously applied phosphatidylinositol 3,4,5-trisphosphate.

  Molecular pharmacology 20070101

• Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.

  Endocrinology 20070101

• The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism.

  Endocrinology 20070101

• Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes.

  The Journal of pharmacology and experimental therapeutics 20070101

• Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate.

  Journal of neurochemistry 20070101

• Proteomics exploration reveals that actin is a signaling target of the kinase Akt.

  Molecular & cellular proteomics : MCP 20070101

• Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways.

  Hypertension (Dallas, Tex. : 1979) 20070101

• Beta(2)-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP.

  Diabetologia 20070101

• Reperfusion kinase phosphorylation is essential but not sufficient in the mediation of pharmacological preconditioning: Characterisation in the bi-phasic profile of early and late protection.

  Cardiovascular research 20070101

• Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells.

  Cardiovascular research 20070101

• Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines.

  Frontiers in bioscience : a journal and virtual library 20070101

• Inhibition of cell death by a novel 16.2 kD heat shock protein predominantly via Hsp90 mediated lipid rafts stabilization and Akt activation pathway.

  Apoptosis : an international journal on programmed cell death 20070101

• In vitro effect of carvedilol on professional phagocytes.

  Pharmacology 20070101

• Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1.

  Microbial pathogenesis 20070101

• Proteomic identification of 14-3-3zeta as an adapter for IGF-1 and Akt/GSK-3beta signaling and survival of renal mesangial cells.

  International journal of biological sciences 20070101

• Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells.

  Radiation oncology (London, England) 20070101

• Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.

  Chemotherapy 20070101

• Rice SCAMP1 defines clathrin-coated, trans-golgi-located tubular-vesicular structures as an early endosome in tobacco BY-2 cells.

  The Plant cell 20070101

• Nerve growth factor prevents the apoptosis-associated increase in acetylcholinesterase activity after hydrogen peroxide treatment by activating Akt.

  Acta biochimica et biophysica Sinica 20070101

• A novel type of autophagy occurs together with vacuole genesis in miniprotoplasts prepared from tobacco culture cells.

  Autophagy 20070101

• P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling.

  BMC cancer 20070101

• The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80.

  Molecular cancer therapeutics 20070101

• Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells.

  Molecular cancer research : MCR 20070101

• Distinct signalling pathways for induction of MAP kinase activities by cadmium and copper in rice roots.

  Journal of experimental botany 20070101

• Cell cycle-dependent association of Rad51 with the nuclear matrix.

  DNA and cell biology 20070101

• Selective loss of TGFbeta Smad-dependent signalling prevents cell cycle arrest and promotes invasion in oesophageal adenocarcinoma cell lines.

  PloS one 20070101

• Transcriptional analysis of three major putative phosphatidylinositol kinase genes in a parasitic protozoan, Giardia lamblia.

  The Journal of eukaryotic microbiology 20070101

• Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.

  Molecular cancer 20070101

• Control of ion transport in mouse proximal and distal colon by prolactin.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Extracellular localization of galectin-3 has a deleterious role in joint tissues.

  Arthritis research & therapy 20070101

• Chemical combination effects predict connectivity in biological systems.

  Molecular systems biology 20070101

• Modulation of erythrocyte hemorheological properties by band 3 phosphorylation and dephosphorylation.

  Clinical hemorheology and microcirculation 20070101

• Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila.

  BMC biology 20070101

• Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells.

  Annals of the New York Academy of Sciences 20070101

• The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention.

  Molecular cancer 20070101

• The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 kinase, but is independent of radical scavenging or bound lipid.

  Journal of vascular research 20070101

• Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves phosphatidylinositol-3-OH kinase-Akt and a mitochondrial permeability transition pore during early reperfusion.

  Journal of anesthesia 20070101

• Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells.

  Pharmacology 20070101

• Life and death in bovine monocytes: the fate of Mycobacterium avium subsp. paratuberculosis.

  Microbial pathogenesis 20070101

• SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence.

  Proteome science 20070101

• Role of phosphoinositide 3-kinase in ischemic postconditioning-induced attenuation of cerebral ischemia-evoked behavioral deficits in mice.

  Pharmacological reports : PR 20070101

• Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation.

  Pharmacological reports : PR 20070101

• NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth.

  Neurochemistry international 20070101

• Uterine smooth muscle cells increase invasive ability of endometrial carcinoma cells through tumor-stromal interaction.

  Clinical & experimental metastasis 20070101

• Repression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but not its receptors during oral cancer progression.

  BMC cancer 20070101

• Interleukin-3 promotes the expression of E-NPP3/CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy.

  International journal of immunopathology and pharmacology 20070101

• Uniaxial cyclic stretch-stimulated glucose transport is mediated by a ca-dependent mechanism in cultured skeletal muscle cells.

  Pathobiology : journal of immunopathology, molecular and cellular biology 20070101

• Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling.

  BMC cell biology 20070101

• Cell signaling and cancer.

  Genome biology 20070101

• Effect of protein kinase inhibitors on protein phosphorylation and germination of aerial spores from Streptomyces coelicolor.

  Folia microbiologica 20070101

• The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I.

  Molecular membrane biology 20070101

• PI3 kinase dependent stimulation of gastric acid secretion by dexamethasone.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Efficacy of barriers and hypoxia-inducible factor inhibitors to prevent CO(2) pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model.

  Journal of minimally invasive gynecology 20070101

• Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-kappaB in immortalized and malignant oral keratinocytes.

  BMC cancer 20070101

• Telmisartan-enhanced hypercholesterolaemic serum-induced vascular endothelial growth factor expression in immortalized human umbilical vascular endothelial cells.

  Scandinavian journal of clinical and laboratory investigation 20070101

• The death of human cancer cells following photodynamic therapy: apoptosis competence is necessary for Bcl-2 protection but not for induction of autophagy.

  Photochemistry and photobiology 20070101

• Flagellin signalling in plant immunity.

  Advances in experimental medicine and biology 20070101

• PI3 K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell lines.

  Journal of molecular signaling 20070101

• Inhibitory effects of 1,25-dihydroxyvitamin D3 and its low-calcemic analogues on staurosporine-induced apoptosis.

  Pharmacological reports : PR 20070101

• Bench-to-bedside review: High-mobility group box 1 and critical illness.

  Critical care (London, England) 20070101

• Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase.

  BMC molecular biology 20070101

• Platelet-derived growth factor-BB amplifies PGF2alpha-stimulated VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase.

  Prostaglandins, leukotrienes, and essential fatty acids 20070101

• Phosphoinositide 3-kinase dependent regulation of Kv channels in dendritic cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival.

  PloS one 20070101

• Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses.

  Molecular systems biology 20070101

• Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes.

  Genome biology 20070101

• Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response.

  Molecular systems biology 20070101

• Evidence that a wortmannin-sensitive signal transduction pathway regulates aflatoxin biosynthesis.

  Mycologia 20070101

• [The effect of phosphatidylinositol kinase inhibitors on store-dependent Ca2(+)-transport in macrophages].

  Tsitologiia 20070101

• Transcriptome of angiopoietin 1-activated human umbilical vein endothelial cells.

  Endothelium : journal of endothelial cell research 20070101

• Neuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/Akt-dependent pathway: potential implications for schizophrenia and cancer.

  PloS one 20070101

• Differentiation of murine B cells induced by chondroitin sulfate B.

  Cellular immunology 20070101

• Polyphasic taxonomy of Aspergillus section Fumigati and its teleomorph Neosartorya.

  Studies in mycology 20070101

• Insulin sensitizing pharmacology of thiazolidinediones correlates with mitochondrial gene expression rather than activation of PPAR gamma.

  Gene regulation and systems biology 20070101

• Annual scientific meeting, edmonton, september 27-30, 2007.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

• Pacemaking by HCN channels requires interaction with phosphoinositides.

  Neuron 20061221

• Phosphatidylinositol 3-kinase/Akt auto-regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts.

  Journal of cellular biochemistry 20061215

• Phosphatidylinositol 4-phosphate is required for translation initiation in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20061215

• Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20061213

• Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.

  Molecular cell 20061208

• Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells.

  Cell death and differentiation 20061201

• Cell invasion by Trypanosoma cruzi amastigotes of distinct infectivities: studies on signaling pathways.

  Parasitology research 20061201

• Ouabain induces cell proliferation through calcium-dependent phosphorylation of Akt (protein kinase B) in opossum kidney proximal tubule cells.

  American journal of physiology. Cell physiology 20061201

• Differing mechanisms of cAMP- versus seawater-induced oocyte maturation in marine nemertean worms I. The roles of serine/threonine kinases and phosphatases.

  Molecular reproduction and development 20061201

• ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways.

  Stem cells (Dayton, Ohio) 20061201

• Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways.

  American journal of physiology. Heart and circulatory physiology 20061201

• Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.

  Journal of leukocyte biology 20061201

• DNA damage-induced RPA focalization is independent of gamma-H2AX and RPA hyper-phosphorylation.

  Journal of cellular biochemistry 20061201

• Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes.

  Molecular and cellular biochemistry 20061201

• Unphosphorylated MARCKS is involved in neurite initiation induced by insulin-like growth factor-I in SH-SY5Y cells.

  Journal of cellular physiology 20061201

• Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts.

  Bone 20061201

• Ultraviolet B-induced matrix metalloproteinase-1 and -3 secretions are mediated via PTEN/Akt pathway in human dermal fibroblasts.

  Journal of cellular physiology 20061201

• Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones.

  Molecular pharmacology 20061201

• Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy.

  The Journal of pharmacology and experimental therapeutics 20061201

• Intracellular peptides of natriuretic peptide receptor-C inhibit vascular hypertrophy via Gqalpha/MAP kinase signaling pathways.

  Cardiovascular research 20061201

• Acute activation of glucose uptake by glucose deprivation in L929 fibroblast cells.

  Biochimie 20061201

• Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction.

  Diabetologia 20061201

• Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factor-stimulated proliferation in Brown Norway rat airway smooth muscle cells.

  Pediatric research 20061201

• Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes.

  Journal of gastroenterology and hepatology 20061201

• Leptin modulates the detrimental effect of Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation on salivary mucin synthesis via ERK-signal transduction.

  Inflammopharmacology 20061201

• Regulation of phosphorylation of tau by protein kinases in rat brain.

  Neurochemical research 20061201

• Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits.

  Anesthesia and analgesia 20061201

• Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.

  Diabetes 20061201

• Effect of carvedilol on reactive oxygen species and enzymes linking innate and adaptive immunity.

  Neuro endocrinology letters 20061201

• Time-dependent transition from H(2)O(2)-extracellular signal-regulated kinase- to O(2)-nitric oxide-dependent mechanisms in the stimulatory effect of leptin on renal Na+/K+/-ATPase in the rat.

  Clinical and experimental pharmacology & physiology 20061201

• Benidipine, a dihydropyridine-Ca2+ channel blocker, increases the endothelial differentiation of endothelial progenitor cells in vitro.

  Hypertension research : official journal of the Japanese Society of Hypertension 20061201

• Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi.

  The Journal of biological chemistry 20061124

• Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion.

  The Journal of biological chemistry 20061117

• Oxidative stress induces H2AX phosphorylation in human spermatozoa.

  FEBS letters 20061113

• Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.

  The Journal of biological chemistry 20061110

• Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway.

  Oncogene 20061109

• Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20061108

• Dexamethasone blocks astroglial differentiation from neural precursor cells.

  Neuroreport 20061106

• Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling.

  The Journal of nutritional biochemistry 20061101

• The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils.

  Cellular signalling 20061101

• Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles.

  Molecular endocrinology (Baltimore, Md.) 20061101

• Filopodia formation via a specific Eph family member and PI3K in immortalized cholangiocytes.

  American journal of physiology. Gastrointestinal and liver physiology 20061101

• Neuregulin-dependent protein synthesis in C2C12 myotubes and rat diaphragm muscle.

  American journal of physiology. Cell physiology 20061101

• Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia.

  Neurochemistry international 20061101

• Augmentation of insulin-stimulated ANP release through tyrosine kinase and PI 3-kinase in diabetic rats.

  Peptides 20061101

• 50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro.

  Biology of reproduction 20061101

• Retinal ganglion cell survival in development: mechanisms of retinal growth hormone action.

  Experimental eye research 20061101

• Enhanced neutrophil motility by granulocyte colony-stimulating factor: the role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

  Immunology 20061101

• Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579.

  Cellular signalling 20061101

• HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways.

  The Journal of surgical research 20061101

• Localization of green fluorescent protein fusions with the seven Arabidopsis vacuolar sorting receptors to prevacuolar compartments in tobacco BY-2 cells.

  Plant physiology 20061101

• IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis.

  The Journal of surgical research 20061101

• Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor.

  Hypertension (Dallas, Tex. : 1979) 20061101

• RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75.

  British journal of pharmacology 20061101

• TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells.

  The Journal of surgical research 20061101

• Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells.

  International journal of oncology 20061101

• Calcineurin and Erk1/2-signaling pathways are involved in the antiapoptotic effect of cyclosporin A on astrocytes exposed to simulated ischemia in vitro.

  Naunyn-Schmiedeberg's archives of pharmacology 20061101

• Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.

  Biochimica et biophysica acta 20061101

• Leptin increases proliferation of human steosarcoma cells through activation of PI(3)-K and MAPK pathways.

  Medical science monitor : international medical journal of experimental and clinical research 20061101

• Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2.

  The Journal of general physiology 20061101

• Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway.

  Journal of pharmacological sciences 20061101

• Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.

  Cytokine 20061101

• [Transfection and anti-HBV effect mediated by the hepatocytes-targeting cationic liposomes co-modified with beta-sitosterol-beta-D-glucoside and Brij 35].

  Yao xue xue bao = Acta pharmaceutica Sinica 20061101

• Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A₃ adenosine receptor.

  Purinergic signalling 20061101

• Signaling pathway of insulin-like growth factor-II as a target of molecular therapy for hepatoblastoma.

  World journal of gastroenterology 20061028

• Gab1 signaling is regulated by EGF receptor sorting in early endosomes.

  Oncogene 20061026

• A role for adrenomedullin as a pain-related peptide in the rat.

  Proceedings of the National Academy of Sciences of the United States of America 20061024

• Exercise training improves insulin-induced and insulin-like growth factor-1-induced vasorelaxation in rat aortas.

  Life sciences 20061019

• Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions.

  Archives of biochemistry and biophysics 20061015

• A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay.

  Biochemical and biophysical research communications 20061013

• Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells.

  The Journal of biological chemistry 20061006

• PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation.

  The EMBO journal 20061004

• Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro.

  Atherosclerosis 20061001

• Preconditioning by 17beta-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS.

  American journal of physiology. Heart and circulatory physiology 20061001

• Overexpression of RGPR-p117 enhances regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells: involvement of TTGGC motif.

  Journal of cellular biochemistry 20061001

• Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes.

  American journal of physiology. Endocrinology and metabolism 20061001

• Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation.

  American journal of physiology. Lung cellular and molecular physiology 20061001

• Role of small bioorganic molecules in stem cell differentiation to insulin-producing cells.

  Bioorganic & medicinal chemistry 20061001

• Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells.

  Molecular pharmacology 20061001

• Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides.

  The Journal of physiology 20061001

• The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway.

  Journal of molecular medicine (Berlin, Germany) 20061001

• Circulating ghrelin concentrations are lowered by intracerebroventricular insulin.

  Diabetologia 20061001

• Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells.

  International journal of oncology 20061001

• UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway.

  International journal of molecular medicine 20061001

• Ciprofloxacin inhibits cytokine-induced nitric oxide production in human colonic epithelium.

  European journal of clinical investigation 20061001

• Activation of cyclic AMP pathway prevents CD34(+) cell apoptosis.

  Experimental hematology 20061001

• Role of phosphatidylinositol-3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand.

  Cancer science 20061001

• Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress.

  Diabetes 20061001

• Distinct mechanisms of nonhomologous end joining in the repair of site-directed chromosomal breaks with noncomplementary and complementary ends.

  Radiation research 20061001

• Differential activation of glucose transport in cultured muscle cells by polyphenolic compounds from Canna indica L. Root.

  Biological & pharmaceutical bulletin 20061001

• Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.

  Cancer research 20061001

• Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases.

  The Journal of endocrinology 20061001

• Regulation of protein L-isoaspartyl methyltransferase by cell-matrix interactions: involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20061001

• Wortmannin delays transfer of human rhinovirus serotype 2 to late endocytic compartments.

  Biochemical and biophysical research communications 20060922

• N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis.

  Biochemical and biophysical research communications 20060922

• FRET analysis reveals a critical conformational change within the Na,K-ATPase alpha1 subunit N-terminus during GPCR-dependent endocytosis.

  FEBS letters 20060918

• Adherent and invasive Escherichia coli are associated with persistent bovine mastitis.

  Veterinary microbiology 20060910

• Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin.

  Biochemical and biophysical research communications 20060908

• AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis.

  Nature 20060907

• Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.

  International journal of cancer 20060901

• Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.

  Journal of cellular biochemistry 20060901

• Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20060901

• Role of mTOR signaling in intestinal cell migration.

  American journal of physiology. Gastrointestinal and liver physiology 20060901

• Effects of hyposmotic stress on exocytosis in isolated turbot, Scophthalmus maximus, hepatocytes.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060901

• Phosphatidylinositol-3-kinase regulates scavenger receptor class B type I subcellular localization and selective lipid uptake in hepatocytes.

  Arteriosclerosis, thrombosis, and vascular biology 20060901

• PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice.

  American journal of physiology. Gastrointestinal and liver physiology 20060901

• Mechanism of beta-bungarotoxin in facilitating spontaneous transmitter release at neuromuscular synapse.

  Neuropharmacology 20060901

• Visualization of PtdIns3P dynamics in living plant cells.

  The Plant journal : for cell and molecular biology 20060901

• The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis.

  Microcirculation (New York, N.Y. : 1994) 20060901

• Sodium orthovanadate induced tyrosine phosphorylation of platelet nitric oxide synthase negatively regulates enzyme activity.

  Biochimica et biophysica acta 20060901

• Heparin binding EGF is necessary for vasospastic response to endothelin.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060901

• Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK.

  Free radical biology & medicine 20060901

• IgE-receptor activation induces survival and Bfl-1 expression in human mast cells but not basophils.

  Allergy 20060901

• Defensins HNP1 and HBD2 stimulation of wound-associated responses in human conjunctival fibroblasts.

  Investigative ophthalmology & visual science 20060901

• Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.

  Cancer research 20060901

• Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060901

• Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks.

  Purinergic signalling 20060901

• Vascular endothelial growth factor increases the intracellular magnesium.

  Biochemical and biophysical research communications 20060825

• Anti-apoptotic effect of hepatocyte growth factor from actinomycin D in hepatocyte-derived HL7702 cells is associated with activation of PI3K/Akt signaling.

  Toxicology letters 20060820

• The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation.

  The Journal of biological chemistry 20060818

• Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia.

  Biochemical and biophysical research communications 20060818

• Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.

  Circulation research 20060818

• Ginsenoside Rg1 inhibits tumor necrosis factor-alpha (TNF-alpha)-induced human arterial smooth muscle cells (HASMCs) proliferation.

  Journal of cellular biochemistry 20060815

• Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels.

  The Journal of physiology 20060815

• Inhibition of the spinal phosphoinositide 3-kinase exacerbates morphine withdrawal response.

  Neuroscience letters 20060814

• Sennidin stimulates glucose incorporation in rat adipocytes.

  Life sciences 20060808

• Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.

  European journal of pharmacology 20060807

• Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kappaB pathways.

  Cellular signalling 20060801

• Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein.

  Toxicology and applied pharmacology 20060801

• Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.

  Journal of cellular biochemistry 20060801

• Enhancement of susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells by phosphatidylinositol 3-kinase inhibitor.

  Oral oncology 20060801

• Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta.

  American journal of physiology. Heart and circulatory physiology 20060801

• Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature.

  American journal of physiology. Heart and circulatory physiology 20060801

• Oleic acid enhances vascular smooth muscle cell proliferation via phosphatidylinositol 3-kinase/Akt signaling pathway.

  Pharmacological research 20060801

• Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion.

  The Journal of pharmacology and experimental therapeutics 20060801

• Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• Regulatory effect of exogenous regucalcin on cell function in osteoblastic MC3T3-E1 cells: involvement of intracellular signaling factor.

  International journal of molecular medicine 20060801

• A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder.

  Naunyn-Schmiedeberg's archives of pharmacology 20060801

• Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells.

  Molecular nutrition & food research 20060801

• 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis.

  Genes to cells : devoted to molecular & cellular mechanisms 20060801

• Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling.

  Diabetes 20060801

• In vitro studies on the signal transduction of thyroidal uptake of 18F-FDG and 131I-Iodide.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20060801

• Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells.

  The Journal of endocrinology 20060801

• Radiation-induced bystander effects and adaptive response in murine lymphocytes.

  International journal of radiation biology 20060801

• Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation interferes with salivary mucin synthesis via platelet activating factor generation.

  Inflammopharmacology 20060801

• Induction of apoptosis by L-NMMA, via FKHRL1/ROCK pathway in human gastric cancer cells.

  Biomedical and environmental sciences : BES 20060801

• [Ischemic postconditioning attenuates ischemia/reperfusion injury in isolated hypertrophied rat heart].

  Zhonghua xin xue guan bing za zhi 20060801

• Gene delivery by dendrimers operates via different pathways in different cells, but is enhanced by the presence of caveolin.

  Journal of immunological methods 20060731

• Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways.

  The Journal of biological chemistry 20060728

• Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-alpha in human monocytes.

  Immunology letters 20060715

• Contribution of PI 3-kinase isoforms to angiotensin II- and alpha-adrenoceptor-mediated signalling pathways in cardiomyocytes.

  Cardiovascular research 20060715

• Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells.

  Biochemical and biophysical research communications 20060714

• Regulation of Fas-mediated apoptosis in neutrophils after surgery-induced acute inflammation.

  The Journal of surgical research 20060701

• Serine 1179 phosphorylation of endothelial nitric oxide synthase caused by 2,4,6-trinitrotoluene through PI3K/Akt signaling in endothelial cells.

  Toxicology and applied pharmacology 20060701

• Vanadium and insulin increase adiponectin production in 3T3-L1 adipocytes.

  Pharmacological research 20060701

• Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells.

  Blood 20060701

• Volatile anesthetic preconditioning attenuates myocardial apoptosis in rabbits after regional ischemia and reperfusion via Akt signaling and modulation of Bcl-2 family proteins.

  The Journal of pharmacology and experimental therapeutics 20060701

• Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.

  Molecular pharmacology 20060701

• Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts.

  Basic research in cardiology 20060701

• N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta.

  The Journal of pharmacology and experimental therapeutics 20060701

• Membrane trafficking factors are involved in the hypotonic activation of the taurine channel in the little skate (Raja erinacea) red blood cell.

  Journal of experimental zoology. Part A, Comparative experimental biology 20060701

• Estrogens cross-talk to alpha1b-adrenergic receptors.

  Molecular pharmacology 20060701

• Induction of human neutrophil chemotaxis by Candida albicans-derived beta-1,6-long glycoside side-chain-branched beta-glucan.

  Journal of leukocyte biology 20060701

• Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1.

  Breast cancer research and treatment 20060701

• Lipid rafts mediate H2O2 prosurvival effects in cultured endothelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701

• The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide.

  Shock (Augusta, Ga.) 20060701

• Plasmacytoid dendritic cell activation by foot-and-mouth disease virus requires immune complexes.

  European journal of immunology 20060701

• Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.

  Diabetes 20060701

• Augmentation of oridonin-induced apoptosis observed with reduced autophagy.

  Journal of pharmacological sciences 20060701

• Angiotensin II-induced delayed stimulation of phospholipase C gamma1 requires activation of both phosphatidylinositol 3-kinase gamma and tyrosine kinase in vascular myocytes.

  Journal of cellular and molecular medicine 20060701

• Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.

  Journal of medicinal chemistry 20060629

• Paradoxical effects of the phage display-derived peptide antagonist IGF-F1-1 on insulin-like growth factor-1 receptor signaling.

  Biochemical pharmacology 20060628

• Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars.

  Life sciences 20060627

• C-reactive protein increases cytokine responses to Streptococcus pneumoniae through interactions with Fc gamma receptors.

  Journal of immunology (Baltimore, Md. : 1950) 20060615

• Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells.

  Biochemical pharmacology 20060614

• Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs.

  Life sciences 20060613

• Involvement of p44/p42 MAP kinase in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblast-like-MC3T3-E1 cells.

  Molecular and cellular endocrinology 20060607

• Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1.

  European journal of pharmacology 20060606

• Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells.

  Cellular signalling 20060601

• Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060601

• Diesel exhaust enhances virus- and poly(I:C)-induced Toll-like receptor 3 expression and signaling in respiratory epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20060601

• Rapamycin antagonizes NF-kappaB nuclear translocation activated by TNF-alpha in primary vascular smooth muscle cells and enhances apoptosis.

  American journal of physiology. Heart and circulatory physiology 20060601

• Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.

  Bone 20060601

• Src oncogene activates MMP-2 expression via the ERK/Sp1 pathway.

  Journal of cellular physiology 20060601

• Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways.

  Biology of reproduction 20060601

• A robust screen for inhibitors and enhancers of phosphoinositide-3 kinase (PI3K) activities by ratiometric fluorescence superquenching.

  Journal of biomolecular screening 20060601

• Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells.

  Endocrinology 20060601

• Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells.

  Journal of cellular physiology 20060601

• Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis.

  Endocrinology 20060601

• Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation.

  Molecular pharmacology 20060601

• Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts.

  Molecular pharmacology 20060601

• Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour.

  The Journal of physiology 20060601

• Initiation of apoptosis and autophagy by photodynamic therapy.

  Lasers in surgery and medicine 20060601

• Steady state analysis and experimental validation of a model for hepatic high-density lipoprotein transport.

  Traffic (Copenhagen, Denmark) 20060601

• The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060601

• Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.

  American journal of physiology. Heart and circulatory physiology 20060601

• Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells.

  Journal of immunology (Baltimore, Md. : 1950) 20060601

• Targeting of the plant vacuolar sorting receptor BP80 is dependent on multiple sorting signals in the cytosolic tail.

  The Plant cell 20060601

• Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells.

  American journal of hypertension 20060601

• Role of PI3-kinase/Akt signalling pathway in renal function and cell proliferation after renal ischaemia/reperfusion injury in mice.

  Nephrology (Carlton, Vic.) 20060601

• Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via phosphatidylinositol-3-kinase/Akt pathway in canine hearts.

  Cardiovascular drugs and therapy 20060601

• Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: a comparison with leukocytes.

  Molecular cancer research : MCR 20060601

• Structure-activity relationship study of the cell-penetrating peptide pVEC.

  Biochimica et biophysica acta 20060601

• 3,5,3' Triiodo-L-thyronine stimulates 2-deoxy-D-glucose transport into L6 muscle cells through the phosphorylation of insulin receptor beta and the activation of PI-3k.

  Thyroid : official journal of the American Thyroid Association 20060601

• Inhibitory effect of antipsychotic drugs on the Con A- and LPS-induced proliferative activity of mouse splenocytes: a possible mechanism of action.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060601

• High-density lipoprotein is a potential growth factor for adrenocortical cells.

  Biochemical and biophysical research communications 20060526

• DNA ligase I is an in vivo substrate of DNA-dependent protein kinase and is activated by phosphorylation in response to DNA double-strand breaks.

  Biochemistry 20060523

• Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060517

• PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells.

  The Prostate 20060515

• Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration.

  Experimental cell research 20060515

• Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis.

  Journal of cell science 20060515

• TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression.

  Journal of immunology (Baltimore, Md. : 1950) 20060515

• PI3K-dependent lysosome exocytosis in nitric oxide-preconditioned hepatocytes.

  Free radical biology & medicine 20060515

• The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy.

  Cancer research 20060515

• Possible mode of action for insulinomimetic activity of vanadyl(IV) compounds in adipocytes.

  Life sciences 20060508

• CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines.

  Cancer chemotherapy and pharmacology 20060501

• Norepinephrine-induced oxidative stress causes PC-12 cell apoptosis by both endoplasmic reticulum stress and mitochondrial intrinsic pathway: inhibition of phosphatidylinositol 3-kinase survival pathway.

  American journal of physiology. Cell physiology 20060501

• Cardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells.

  American journal of physiology. Renal physiology 20060501

• Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.

  Molecular endocrinology (Baltimore, Md.) 20060501

• PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation.

  European journal of cell biology 20060501

• Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells.

  Journal of cellular physiology 20060501

• Amadori-modified glycated albumin predominantly induces E-selectin expression on human umbilical vein endothelial cells through NADPH oxidase activation.

  Clinica chimica acta; international journal of clinical chemistry 20060501

• Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.

  Endocrinology 20060501

• Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins.

  Endocrinology 20060501

• Pregnancy-enhanced endothelial nitric oxide synthase (eNOS) activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple levels of cell signaling.

  Endocrinology 20060501

• Hyaluronan oligosaccharides induce cell death through PI3-K/Akt pathway independently of NF-kappaB transcription factor.

  Glycobiology 20060501

• Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase.

  Bioorganic & medicinal chemistry letters 20060501

• Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-{kappa}B by phosphoinositide 3-kinase.

  Molecular pharmacology 20060501

• Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells.

  Molecular pharmacology 20060501

• Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20060501

• Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism.

  Endocrinology 20060501

• Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20060501

• Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3beta.

  Journal of molecular and cellular cardiology 20060501

• Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20060501

• In vitro effects of insulin-like growth factors and insulin on oocyte maturation and maturation-inducing steroid production in ovarian follicles of common carp, Cyprinus carpio.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20060501

• Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.

  Cardiovascular research 20060501

• Stimulation of interferon-beta gene expression by human cytomegalovirus via nuclear factor kappa B and phosphatidylinositol 3-kinase pathway.

  Virus research 20060501

• Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes.

  Diabetologia 20060501

• Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors.

  The Plant cell 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Multiple vacuolar sorting determinants exist in soybean 11S globulin.

  The Plant cell 20060501

• Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing.

  European journal of immunology 20060501

• Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival.

  Journal of immunology (Baltimore, Md. : 1950) 20060501

• Activation of Akt by mechanical stretching in human epidermal keratinocytes.

  Experimental dermatology 20060501

• Stromal cell derived factor-1 acutely promotes neural progenitor cell proliferation in vitro by a mechanism involving the ERK1/2 and PI-3K signal pathways.

  Cell biology international 20060501

• Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo.

  Anesthesia and analgesia 20060501

• CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils.

  European journal of clinical investigation 20060501

• The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization.

  Investigative ophthalmology & visual science 20060501

• Phosphatidylinositol 3-kinase-dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced diabetic heart.

  Diabetes 20060501

• Regulators for blood glucose level affect gene expression of aquaporin 3.

  Biological & pharmaceutical bulletin 20060501

• Arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidence.

  Environmental health perspectives 20060501

• Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole.

  PLoS pathogens 20060501

• Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.

  Molecular cancer therapeutics 20060501

• Are class II phosphoinositide 3-kinases potential targets for anticancer therapies?

  Bulletin du cancer 20060501

• Dinuclear alkylamine platinum(II) complexes of [1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II): influence of endocytosis and copper and organic cation transport systems on cellular uptake.

  ChemMedChem 20060501

• CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.

  The Journal of biological chemistry 20060421

• Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.

  Journal of the National Cancer Institute 20060419

• Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle.

  Journal of cellular biochemistry 20060415

• Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells.

  The Biochemical journal 20060415

• IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma.

  Biochemical and biophysical research communications 20060414

• Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.

  DNA repair 20060408

• The anti-apoptotic effect of leukotriene B4 in neutrophils: a role for phosphatidylinositol 3-kinase, extracellular signal-regulated kinase and Mcl-1.

  Cellular signalling 20060401

• Inhibition of phosphatidylinositol 3-kinase stimulates activity of the small-conductance K channel in the CCD.

  American journal of physiology. Renal physiology 20060401

• Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401

• Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt.

  American journal of physiology. Gastrointestinal and liver physiology 20060401

• Glycogen synthase kinase-3 phosphorylation, T-cell factor signaling activation, and cell morphology change following stimulation of thromboxane receptor alpha.

  The Journal of pharmacology and experimental therapeutics 20060401

• Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both.

  Glia 20060401

• Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling.

  The Journal of pharmacology and experimental therapeutics 20060401

• Entamoeba histolytica: FYVE-finger domains, phosphatidylinositol 3-phosphate biosensors, associate with phagosomes but not fluid filled endosomes.

  Experimental parasitology 20060401

• Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells.

  Carcinogenesis 20060401

• Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models.

  Endocrinology 20060401

• Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells.

  Endocrinology 20060401

• An important pool of sucrose linked to starch biosynthesis is taken up by endocytosis in heterotrophic cells.

  Plant & cell physiology 20060401

• Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines.

  Experimental cell research 20060401

• Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells.

  Vascular pharmacology 20060401

• Control of neurite outgrowth and growth cone motility by phosphatidylinositol-3-kinase.

  Cell motility and the cytoskeleton 20060401

• Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.

  Arteriosclerosis, thrombosis, and vascular biology 20060401

• Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure.

  Diabetologia 20060401

• The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells.

  Journal of neurochemistry 20060401

• PTEN sensitizes epidermal growth factor-mediated proliferation in endometrial carcinoma cells.

  Oncology reports 20060401

• Contribution of Src-FAK signaling to the induction of connective tissue growth factor in renal fibroblasts.

  Kidney international 20060401

• Structural reorganizations of the endoplasmic reticulum during egg maturation and fertilization.

  Seminars in cell & developmental biology 20060401

• Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.

  Autonomic & autacoid pharmacology 20060401

• beta 2-Adrenergic stimulation is involved in the contractile dysfunction of the stunned heart.

  Naunyn-Schmiedeberg's archives of pharmacology 20060401

• Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway.

  Molecular cancer therapeutics 20060401

• Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis.

  IUBMB life 20060401

• Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3-kinase inhibition in the human cervical cancer cell-line.

  Cancer research and treatment : official journal of Korean Cancer Association 20060401

• Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways.

  Chemico-biological interactions 20060325

• Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.

  Biochemical and biophysical research communications 20060324

• Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.

  The Biochemical journal 20060315

• Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation.

  Free radical biology & medicine 20060315

• Tumours and tremors: how PTEN regulation underlies both.

  British journal of cancer 20060313

• Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.

  Biochemical and biophysical research communications 20060310

• Neuroprotective effect of the stearic acid against oxidative stress via phosphatidylinositol 3-kinase pathway.

  Chemico-biological interactions 20060310

• Green tea polyphenol epigallocatechin-3-gallate protects cells against peroxynitrite-induced cytotoxicity: modulatory effect of cellular G6PD status.

  Journal of agricultural and food chemistry 20060308

• Feed forward cycle of hypotonic stress-induced ATP release, purinergic receptor activation, and growth stimulation of prostate cancer cells.

  The Journal of biological chemistry 20060303

• High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.

  Cellular signalling 20060301

• Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide.

  Archives of toxicology 20060301

• The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20060301

• Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors.

  Journal of cellular physiology 20060301

• Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection.

  The international journal of biochemistry & cell biology 20060301

• Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway.

  Basic research in cardiology 20060301

• Mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K) pathways differently regulate retinal pigment epithelial cell-mediated collagen gel contraction.

  Experimental eye research 20060301

• Identification of the insulin signaling cascade in the regulation of alpha-class glutathione S-transferase expression in primary cultured rat hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20060301

• Targeting the signaling pathway of acylation stimulating protein.

  Journal of lipid research 20060301

• Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols.

  Molecular pharmacology 20060301

• Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein kinase C signaling pathways.

  The Journal of investigative dermatology 20060301

• The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• Signal transduction events involved in human epithelial cell invasion by Campylobacter jejuni 81-176.

  Microbial pathogenesis 20060301

• Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function.

  Diabetologia 20060301

• Protein kinase CK2 subunits are positive regulators of AKT kinase.

  International journal of oncology 20060301

• Vascular endothelial growth factor-induced signaling pathways in endothelial cells that mediate overexpression of the chemokine IFN-gamma-inducible protein of 10 kDa in vitro and in vivo.

  Journal of immunology (Baltimore, Md. : 1950) 20060301

• Effects of protein kinase and phosphatidylinositol-3 kinase inhibitors on growth and ultrastructure of Trypanosoma cruzi.

  FEMS microbiology letters 20060301

• Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.

  The Journal of endocrinology 20060301

• Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.

  Molecular cancer therapeutics 20060301

• N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum.

  Journal of natural products 20060301

• Akt in the pathogenesis of COPD.

  International journal of chronic obstructive pulmonary disease 20060301

• Shear stress stimulates phosphorylation of protein kinase A substrate proteins including endothelial nitric oxide synthase in endothelial cells.

  Experimental & molecular medicine 20060227

• Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.

  The Journal of biological chemistry 20060224

• Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape.

  The Journal of biological chemistry 20060224

• Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.

  Journal of medicinal chemistry 20060223

• PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation.

  World journal of gastroenterology 20060221

• Zinc as an insulin replacement in hybridoma cultures.

  Biotechnology and bioengineering 20060220

• Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.

  International journal of cancer 20060215

• Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells.

  Experimental cell research 20060215

• Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway.

  Cancer research 20060215

• Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion.

  Biochemical pharmacology 20060214

• Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells.

  The Journal of biological chemistry 20060210

• Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia.

  FEBS letters 20060206

• Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.

  Cell death and differentiation 20060201

• Tryptase activates phosphatidylinositol 3-kinases proteolytically independently from proteinase-activated receptor-2 in cultured dog airway smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20060201

• Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

  Journal of cellular biochemistry 20060201

• Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1.

  American journal of respiratory cell and molecular biology 20060201

• Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum.

  The Journal of pharmacology and experimental therapeutics 20060201

• delta opioid receptors stimulate Akt-dependent phosphorylation of c-jun in T cells.

  The Journal of pharmacology and experimental therapeutics 20060201

• Involvement of multiple phosphatidylinositol 3-kinase-dependent pathways in the persistence of late-phase long term potentiation expression.

  Neuroscience 20060201

• Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism.

  American journal of physiology. Cell physiology 20060201

• Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells.

  Traffic (Copenhagen, Denmark) 20060201

• Autophagy: a forty-year search for a missing membrane source.

  PLoS biology 20060201

• AKT pathway is activated by 1, 25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells.

  Cell cycle (Georgetown, Tex.) 20060201

• Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells.

  Biochimica et biophysica acta 20060201

• Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.

  Molecular cancer therapeutics 20060201

• Nitric oxide stimulates vascular endothelial growth factor production in cardiomyocytes involved in angiogenesis.

  The journal of physiological sciences : JPS 20060201

• Protein kinase B inhibits endostatin-induced apoptosis in HUVECs.

  Journal of biochemistry and molecular biology 20060131

• Wortmannin-C20 conjugates generate wortmannin.

  Journal of medicinal chemistry 20060126

• Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration.

  FEBS letters 20060123

• Signaling transduction pathways involved in basophil adhesion and histamine release.

  Chinese medical journal 20060120

• Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis.

  Organic letters 20060119

• Adrenomedullin and tumour angiogenesis.

  British journal of cancer 20060116

• The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states.

  Blood 20060115

• P2X7 receptor-dependent ATP-induced shedding of CD27 in mouse lymphocytes.

  Immunology letters 20060115

• Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.

  The Journal of physiology 20060115

• Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways.

  Journal of immunology (Baltimore, Md. : 1950) 20060115

• Role of Per1-interacting protein of the suprachiasmatic nucleus in NGF mediated neuronal survival.

  Biochemical and biophysical research communications 20060113

• Cholecystokinin stimulates the recruitment of the Src-RhoA-phosphoinositide 3-kinase pathway by Vav-2 downstream of G(alpha13) in pancreatic acini.

  Biochemical and biophysical research communications 20060106

• Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway.

  Oncogene 20060105

• Methylene blue stimulates 2-deoxyglucose uptake in L929 fibroblast cells.

  Life sciences 20060102

• Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.

  Journal of cellular physiology 20060101

• Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture.

  Journal of neural transmission (Vienna, Austria : 1996) 20060101

• Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation.

  Stem cells (Dayton, Ohio) 20060101

• Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging.

  American journal of physiology. Gastrointestinal and liver physiology 20060101

• Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor.

  Blood 20060101

• Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt.

  American journal of physiology. Heart and circulatory physiology 20060101

• Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS.

  American journal of physiology. Heart and circulatory physiology 20060101

• Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.

  The Journal of surgical research 20060101

• PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning.

  Cardiovascular research 20060101

• IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.

  Cardiovascular research 20060101

• Mitochondria play a critical role in shaping the exocytotic response of rat pancreatic acinar cells.

  Cell calcium 20060101

• Integrin stimulation induces calcium signalling in rat cardiomyocytes by a NO-dependent mechanism.

  Pflugers Archiv : European journal of physiology 20060101

• Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and survivin expression in rat ischemic preconditioned myocardium.

  Journal of molecular and cellular cardiology 20060101

• Signaling mechanism of thrombin-induced gingival fibroblast-populated collagen gel contraction.

  British journal of pharmacology 20060101

• Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack.

  Journal of neuroscience research 20060101

• Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells.

  International journal of molecular medicine 20060101

• Anaesthetic sensitivity of fMLP-induced cell signalling in Xenopus oocytes.

  International immunopharmacology 20060101

• Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin.

  Pain 20060101

• Differential regulation of interleukin-12 and tumour necrosis factor-alpha by phosphatidylinositol 3-kinase and ERK 1/2 pathways during Mycobacterium tuberculosis infection.

  Clinical and experimental immunology 20060101

• Analyzing the mechanism of Rap1 activation in platelets: Rap1 activation is related to the release reaction mediated through the collagen receptor GPVI.

  Thrombosis research 20060101

• Inhibitors of phosphatidylinositol 3-kinase activity prevent cell cycle progression and induce apoptosis at the M/G1 transition in CHO cells.

  Cellular and molecular life sciences : CMLS 20060101

• Activation of nitric oxide modulator effect by isometric contraction in rat resistance arteries.

  Journal of cardiovascular pharmacology 20060101

• Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells.

  Molecular cancer therapeutics 20060101

• Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates.

  Cell communication and signaling : CCS 20060101

• Intracellular assembly and budding of the Murine Leukemia Virus in infected cells.

  Retrovirology 20060101

• TC10 and insulin-stimulated glucose transport.

  Methods in enzymology 20060101

• Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals.

  BMC cell biology 20060101

• The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis.

  Arthritis research & therapy 20060101

• Epithelial cells secrete interleukin-8 in response to adhesion and invasion of diffusely adhering Escherichia coli lacking Afa/Dr genes.

  Microbiology and immunology 20060101

• CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation.

  Respiratory research 20060101

• Albumin stimulation of eosinophil migration involves PI3-kinases and is associated with diminished eosinophil CD49d and CD49f expression.

  International archives of allergy and immunology 20060101

• The role of phosphatidylinositol-3-kinase in the formation of oxygen radicals by phagocytes in whole blood samples from patients with coronary heart disease.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20060101

• Pharmacological evidence for activation of phospholipid and small GTP binding protein signalling cascades by Nod factors.

  Plant physiology and biochemistry : PPB 20060101

• Melatonin in Alzheimer's disease and other neurodegenerative disorders.

  Behavioral and brain functions : BBF 20060101

• Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages.

  Journal of inflammation (London, England) 20060101

• Evidence from bioinformatics, expression and inhibition studies of phosphoinositide-3 kinase signalling in Giardia intestinalis.

  BMC microbiology 20060101

• Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation.

  Radiation oncology (London, England) 20060101

• Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1.

  Retrovirology 20060101

• Influence of wortmannin on the inotropic effect of insulin in papillary muscles of Siberian ground squirrel heart.

  Doklady. Biochemistry and biophysics 20060101

• Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells.

  BMC neuroscience 20060101

• Shear stress protects against endothelial regulation of vascular smooth muscle cell migration in a coculture system.

  Endothelium : journal of endothelial cell research 20060101

• Activation of phosphoinositide 3-kinase C2 beta in the nuclear matrix during compensatory liver growth.

  Advances in enzyme regulation 20060101

• Thyroid hormone mediated changes in gene expression can be initiated by cytosolic action of the thyroid hormone receptor beta through the phosphatidylinositol 3-kinase pathway.

  Nuclear receptor signaling 20060101

• Autophagy: a highway for Porphyromonas gingivalis in endothelial cells.

  Autophagy 20060101

• Autophagy can be a killer even in apoptosis-competent cells.

  Autophagy 20060101

• Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes.

  Autophagy 20060101

• Fluvastatin prevents oxidized low-density lipoprotein-induced injury of renal tubular epithelial cells by inhibiting the phosphatidylinositol 3-kinase/Akt-signaling pathway.

  Journal of nephrology 20060101

• 'Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells'.

  Cancer cell international 20060101

• P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels.

  BMC cell biology 20060101

• EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation.

  BMC cell biology 20060101

• IGF regulation of neutral amino acid transport in the BeWo choriocarcinoma cell line (b30 clone): evidence for MAP kinase-dependent and MAP kinase-independent mechanisms.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20060101

• CellProfiler: image analysis software for identifying and quantifying cell phenotypes.

  Genome biology 20060101

• [PI3-kinase inhibitors LY294002 and wortmannin have different effects on proliferation of murine embryonic stem cells].

  Tsitologiia 20060101

• Membrane trafficking and osmotically induced volume changes in guard cells.

  Journal of experimental botany 20060101

• Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets.

  Biological research 20060101

• Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter.

  BMC molecular biology 20060101

• Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells.

  Cell structure and function 20060101

• Nectin-2-mediated entry of a syncytial strain of herpes simplex virus via pH-independent fusion with the plasma membrane of Chinese hamster ovary cells.

  Virology journal 20060101

• Involvement of PI3-K in neuroprotective effects of the 1,25-dihydroxyvitamin D3 analogue - PRI-2191.

  Pharmacological reports : PR 20060101

• Theoretical and experimental investigation of calcium-contraction coupling in airway smooth muscle.

  Cell biochemistry and biophysics 20060101

• Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.

  The Journal of biological chemistry 20051230

• Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes.

  The Journal of biological chemistry 20051223

• Arguments raised by the recent discovery that insulin and leptin are expressed in and secreted by human ejaculated spermatozoa.

  Molecular and cellular endocrinology 20051221

• NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.

  The EMBO journal 20051221

• Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.

  International journal of cancer 20051220

• Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase).

  Circulation 20051220

• Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle.

  The Biochemical journal 20051215

• Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K.

  Journal of immunology (Baltimore, Md. : 1950) 20051215

• mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.

  The Journal of biological chemistry 20051209

• PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning.

  Circulation research 20051209

• Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome.

  DNA repair 20051208

• Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF.

  Cytokine 20051207

• Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.

  Cellular signalling 20051201

• Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.

  Peptides 20051201

• Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway.

  Cardiovascular research 20051201

• Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling.

  The Journal of pharmacology and experimental therapeutics 20051201

• The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration.

  Cellular signalling 20051201

• Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.

  Molecular carcinogenesis 20051201

• Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis.

  Laboratory investigation; a journal of technical methods and pathology 20051201

• Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051201

• PI3-kinase is essential for ADP-stimulated integrin alpha(IIb)beta3-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin alpha(IIb)beta3-initiated signaling cross-talks.

  Journal of biomedical science 20051201

• The vanadyl (VO2+) chelate bis(acetylacetonato)oxovanadium(IV) potentiates tyrosine phosphorylation of the insulin receptor.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20051201

• Evidence that insulin-like growth factor-1 requires protein kinase C-epsilon, PI3-kinase and mitogen-activated protein kinase pathways to protect human vascular smooth muscle cells from apoptosis.

  Immunology and cell biology 20051201

• The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides.

  Journal of neurochemistry 20051201

• Isoflurane-induced myocardial preconditioning is dependent on phosphatidylinositol-3-kinase/Akt signalling.

  British journal of anaesthesia 20051201

• Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20051201

• Effect of nitric oxide on gamma-ray-induced micronucleus frequency in RAW264.7 cells.

  Radiation research 20051201

• Binding of PLCdelta1PH-GFP to PtdIns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of PtdIns(4,5)P2 by neomycin.

  Acta pharmacologica Sinica 20051201

• Complement regulatory protein Crry/p65-mediated signaling in T lymphocytes: role of its cytoplasmic domain and partitioning into lipid rafts.

  Journal of leukocyte biology 20051201

• Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPK.

  Journal of cardiovascular pharmacology 20051201

• Inhibition of the phosphatidylinositol 3'-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes.

  Metabolism: clinical and experimental 20051201

• Differential expression of IGF-binding protein-3 in normal and malignant colon and its influence on apoptosis.

  Endocrine-related cancer 20051201

• Bone morphogenetic protein-2-induced transformation involves the activation of mammalian target of rapamycin.

  Molecular cancer research : MCR 20051201

• LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II.

  Purinergic signalling 20051201

• Genome concatenation contributes to the late gene expression defect of an adenovirus E4 mutant.

  Virology 20051125

• Okadaic acid increases the phosphorylation state of alpha1A-adrenoceptors and induces receptor desensitization.

  European journal of pharmacology 20051121

• Downregulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells.

  International journal of cancer 20051120

• Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.

  The Journal of biological chemistry 20051118

• PI3-kinase activation by GM-CSF in endothelium is upstream of Jak/Stat pathway: role of alphaGMR.

  Biochemical and biophysical research communications 20051118

• Protein kinase C shifts the voltage dependence of KCNQ/M channels expressed in Xenopus oocytes.

  The Journal of physiology 20051115

• Rab5 and Rab7, but not ARF6, govern the early events of HIV-1 infection in polarized human placental cells.

  Journal of immunology (Baltimore, Md. : 1950) 20051115

• Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane.

  Biology of the cell 20051101

• Atypical PKC-zeta and PKC-iota mediate opposing effects on MCF-7 Na+/K+ATPase activity.

  Journal of cellular physiology 20051101

• Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules.

  American journal of physiology. Renal physiology 20051101

• Abeta25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20051101

• p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.

  American journal of physiology. Lung cellular and molecular physiology 20051101

• Steroid-induced oocyte maturation in Atlantic croaker (Micropogonias undulatus) is dependent on activation of the phosphatidylinositol 3-kinase/Akt signal transduction pathway.

  Biology of reproduction 20051101

• 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells.

  Molecular pharmacology 20051101

• Cellular dynamics and modulation of WRN protein is DNA damage specific.

  Mechanisms of ageing and development 20051101

• Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells.

  Endocrinology 20051101

• Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases.

  Bioorganic & medicinal chemistry letters 20051101

• Hydrophilic bile salt ursodeoxycholic acid protects myocardium against reperfusion injury in a PI3K/Akt dependent pathway.

  Journal of molecular and cellular cardiology 20051101

• Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20051101

• Enhancement of susceptibility to Fas-mediated apoptosis in HL-60 cells through down-regulation of cellular FLICE-inhibitory protein by phosphatidylinositol 3-kinase inhibitors.

  Oncology reports 20051101

• Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway.

  Cancer biology & therapy 20051101

• Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism.

  Platelets 20051101

• Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase.

  Toxicology and applied pharmacology 20051101

• Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation.

  Journal of thrombosis and haemostasis : JTH 20051101

• Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line.

  Journal of neurochemistry 20051101

• Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression.

  Anesthesiology 20051101

• Elevated glucose activates protein synthesis in cultured cardiac myocytes.

  Metabolism: clinical and experimental 20051101

• Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2.

  Vascular pharmacology 20051101

• Induction of proinflammatory cytokines and C-reactive protein in human macrophage cell line U937 exposed to air pollution particulates.

  Environmental health perspectives 20051101

• Insulin signaling in adipocytes differentiated from mouse stromal MC3T3-G2/PA6 cells.

  Biological & pharmaceutical bulletin 20051101

• Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression.

  Molecular and cellular biochemistry 20051101

• Chronic ethanol exposure stimulates endothelial cell nitric oxide production through PI-3 kinase-and hsp90-dependent mechanisms.

  Alcoholism, clinical and experimental research 20051101

• Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026.

  British journal of cancer 20051031

• Insulin cannot activate extracellular-signal-related kinase due to inability to generate reactive oxygen species in SK-N-BE(2) human neuroblastoma cells.

  Molecules and cells 20051031

• Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner.

  Blood 20051015

• A rapid, nongenomic pathway facilitates the synaptic transmission induced by retinoic acid at the developing synapse.

  Journal of cell science 20051015

• Phosphatidylinositol 3-kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide.

  Cellular and molecular biology (Noisy-le-Grand, France) 20051003

• Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells.

  Blood 20051001

• Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics.

  American journal of physiology. Cell physiology 20051001

• Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes.

  American journal of physiology. Endocrinology and metabolism 20051001

• Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20051001

• Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis.

  Molecular pharmacology 20051001

• Monomeric and oligomeric flavanols are agonists of membrane androgen receptors.

  Experimental cell research 20051001

• Role of HER-2/neu signaling in sensitivity to tumor necrosis factor-related apoptosis-inducing ligand: enhancement of TRAIL-mediated apoptosis by amiloride.

  Journal of cellular biochemistry 20051001

• HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

  Journal of leukocyte biology 20051001

• T-cadherin protects endothelial cells from oxidative stress-induced apoptosis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051001

• Signaling through interleukin-1 type 1 receptor diminishes Haemophilus somnus lipooligosaccharide-mediated apoptosis of endothelial cells.

  Microbial pathogenesis 20051001

• Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells.

  Cell cycle (Georgetown, Tex.) 20051001

• Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells.

  International journal of molecular medicine 20051001

• Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.

  Acta pharmacologica Sinica 20051001

• Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits.

  Anesthesia and analgesia 20051001

• A role for PKCzeta in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin.

  Molecular cancer therapeutics 20051001

• Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

  Molecular cancer therapeutics 20051001

• Role of chemokine signaling pathways in pancreatic islet rejection during allo- and xenotransplantation.

  Transplantation proceedings 20051001

• Chronic erythropoietin treatment limits infarct-size in the myocardium in vitro.

  Cardiovascular drugs and therapy 20051001

• Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein beta.

  The Journal of biological chemistry 20050930

• D-3 phosphoinositides of the ciliate Tetrahymena: characterization and study of their regulatory role in lysosomal enzyme secretion.

  Biochimica et biophysica acta 20050930

• LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways.

  Biochemical and biophysical research communications 20050930

• Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.

  The Journal of biological chemistry 20050923

• Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity.

  The Journal of biological chemistry 20050923

• Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.

  European journal of pharmacology 20050905

• Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.

  Biochemical and biophysical research communications 20050902

• Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP.

  American journal of physiology. Renal physiology 20050901

• PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells.

  American journal of physiology. Cell physiology 20050901

• Mechanism of the vascular angiotensin II/alpha2-adrenoceptor interaction.

  The Journal of pharmacology and experimental therapeutics 20050901

• Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells.

  Cardiovascular research 20050901

• Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo.

  Basic research in cardiology 20050901

• Phosphatidylinositol 3-kinase and ERK1/2 are not involved in adenosine A1, A2A or A3 receptor-mediated preconditioning in rat ventricle strips.

  Experimental physiology 20050901

• The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway.

  British journal of pharmacology 20050901

• Adenosine triggers preconditioning through MEK/ERK1/2 signalling pathway during hypoxia/reoxygenation in neonatal rat cardiomyocytes.

  Journal of molecular and cellular cardiology 20050901

• Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K).

  Allergy 20050901

• The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells.

  International journal of oncology 20050901

• Psoriasin (S100A7) and calgranulin-B (S100A9) induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants.

  Cancer biology & therapy 20050901

• Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity.

  Journal of hypertension 20050901

• PilT is required for PI(3,4,5)P3-mediated crosstalk between Neisseria gonorrhoeae and epithelial cells.

  Cellular microbiology 20050901

• Pacemaker activity in urethral interstitial cells is not dependent on capacitative calcium entry.

  American journal of physiology. Cell physiology 20050901

• Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts.

  Journal of neurochemistry 20050901

• Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes.

  European journal of immunology 20050901

• G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK.

  Journal of immunology (Baltimore, Md. : 1950) 20050901

• Acute activation of Erk1/Erk2 and protein kinase B/akt proceed by independent pathways in multiple cell types.

  The FEBS journal 20050901

• Galectin-3 inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by activating Akt in human bladder carcinoma cells.

  Cancer research 20050901

• Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.

  Cancer research 20050901

• L-selectin expression on neutrophils from allergic patients.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050901

• Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.

  Endocrine-related cancer 20050901

• Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism.

  The European journal of neuroscience 20050901

• Endothelial nitric oxide production stimulated by the bioflavonoid chrysin in rat isolated aorta.

  Planta medica 20050901

• Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt.

  Thrombosis and haemostasis 20050901

• Identification and preliminary SAR studies of (+)-Geodin as a glucose uptake stimulator for rat adipocytes.

  The Journal of antibiotics 20050901

• Sesamol induces nitric oxide release from human umbilical vein endothelial cells.

  Lipids 20050901

• Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of phosphatidylinositol 3-kinase/AKT kinase.

  Circulation 20050830

• Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells.

  Biochemical and biophysical research communications 20050819

• The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells.

  Oncogene 20050818

• Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells.

  Blood 20050815

• Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinase.

  Journal of neuroscience research 20050815

• Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes.

  Journal of cellular biochemistry 20050815

• Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.

  Journal of neuroscience research 20050815

• The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo.

  Developmental biology 20050815

• PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone.

  Journal of cell science 20050815

• 15(S)-hydroxyeicosatetraenoic acid induces angiogenesis via activation of PI3K-Akt-mTOR-S6K1 signaling.

  Cancer research 20050815

• A cell-permeable, activity-based probe for protein and lipid kinases.

  The Journal of biological chemistry 20050812

• Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis.

  International journal of cancer 20050810

• Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides.

  The Journal of biological chemistry 20050805

• Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway.

  Circulation 20050802

• Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells.

  Journal of cellular physiology 20050801

• Leptin-induced nitric oxide production in white adipocytes is mediated through PKA and MAP kinase activation.

  American journal of physiology. Cell physiology 20050801

• Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems.

  American journal of physiology. Cell physiology 20050801

• Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.

  American journal of physiology. Heart and circulatory physiology 20050801

• IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

  The Biochemical journal 20050801

• Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697.

  The Biochemical journal 20050801

• Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation.

  Molecular endocrinology (Baltimore, Md.) 20050801

• Phosphoinositide 3-kinase is required for human adipocyte differentiation in culture.

  International journal of obesity (2005) 20050801

• Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line.

  Molecular & cellular proteomics : MCP 20050801

• Signaling through CD16b in human neutrophils involves the Tec family of tyrosine kinases.

  Journal of leukocyte biology 20050801

• Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801

• A possible signal transduction pathway for cyclin D2 expression by a pectic polysaccharide from the roots of bupleurum falcatum L. in murine B cell.

  International immunopharmacology 20050801

• Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.

  Journal of the American Society of Nephrology : JASN 20050801

• Inhibitory effect of imipramine on the human corticotropin-releasing-hormone gene promoter activity operates through a PI3-K/AKT mediated pathway.

  Neuropharmacology 20050801

• Interactions of the integrin subunit beta1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20050801

• PMA-enhanced neutrophil [18F]FDG uptake is independent of integrin occupancy but requires PI3K activity.

  Nuclear medicine and biology 20050801

• Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.

  Journal of pharmacological sciences 20050801

• Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis.

  Gastroenterology 20050801

• Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats.

  Journal of molecular endocrinology 20050801

• Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.

  Nature cell biology 20050801

• The immunostimulatory peptide WKYMVm-NH activates bone marrow mouse neutrophils via multiple signal transduction pathways.

  Scandinavian journal of immunology 20050801

• Role of leptin in modulation of Porphyromonas gingivalis lipopolysaccharide-induced up-regulation of endothelin-1 in salivary gland acinar cells.

  IUBMB life 20050801

• Alteration in the expression of signaling parameters following carbon ion irradiation.

  Molecular and cellular biochemistry 20050801

• Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity.

  Apoptosis : an international journal on programmed cell death 20050801

• The effect of wortmannin on radiation-induced chromosome aberration formation in the radioresistant tumor cell line WiDr.

  Radiation research 20050801

• Signaling pathway in nerve growth factor induced histamine release from rat mast cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050801

• The PPAR-gamma activator, Rosiglitazone, inhibits actin polymerisation in monocytes: involvement of Akt and intracellular calcium.

  Biochemical and biophysical research communications 20050729

• Histamine induces tissue factor expression: implications for acute coronary syndromes.

  Circulation 20050719

• Host cell signaling and Trypanosoma cruzi invasion: do all roads lead to lysosomes?

  Science's STKE : signal transduction knowledge environment 20050719

• The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling.

  The Journal of biological chemistry 20050715

• Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.

  The Journal of biological chemistry 20050715

• T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho.

  Biochemical and biophysical research communications 20050715

• PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells.

  Life sciences 20050715

• Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53.

  Cancer research 20050715

• LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway.

  Cancer research 20050715

• Biocompatible polymer enhances the in vitro and in vivo transfection efficiency of HVJ envelope vector.

  The journal of gene medicine 20050701

• Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers.

  American journal of physiology. Gastrointestinal and liver physiology 20050701

• Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha/NF-kappaB pathway.

  Journal of leukocyte biology 20050701

• Protein breakdown in muscle from burned rats is blocked by insulin-like growth factor i and glycogen synthase kinase-3beta inhibitors.

  Endocrinology 20050701

• Regulation of interleukin-5-induced beta2-integrin adhesion of human eosinophils by phosphoinositide 3-kinase.

  American journal of respiratory cell and molecular biology 20050701

• PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis.

  Molecular reproduction and development 20050701

• Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori.

  Journal of leukocyte biology 20050701

• Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis.

  Journal of leukocyte biology 20050701

• Morphogenetic plasticity of adult human pancreatic islets of Langerhans.

  Cell death and differentiation 20050701

• The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain.

  The international journal of biochemistry & cell biology 20050701

• Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway.

  Journal of the American Society of Nephrology : JASN 20050701

• Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.

  Drug metabolism and disposition: the biological fate of chemicals 20050701

• Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.

  Molecular pharmacology 20050701

• The antidepressant imipramine inhibits M current by activating a phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent pathway in rat sympathetic neurones.

  British journal of pharmacology 20050701

• Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

  Molecular pharmacology 20050701

• Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes.

  Arteriosclerosis, thrombosis, and vascular biology 20050701

• Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation.

  The Journal of biological chemistry 20050701

• Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide.

  The Journal of biological chemistry 20050701

• Plasmin induces smooth muscle cell proliferation.

  The Journal of surgical research 20050701

• Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases.

  The Journal of biological chemistry 20050701

• Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase.

  The Journal of biological chemistry 20050701

• c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1.

  Experimental cell research 20050701

• Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.

  European journal of immunology 20050701

• Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages.

  Immunology 20050701

• Subset-dependent modulation of dendritic cell activity by circovirus type 2.

  Immunology 20050701

• Phosphorylation of p42/44 MAP kinase is required for rF1-induced activation of murine peritoneal macrophages.

  Molecular immunology 20050701

• Urokinase-induced smooth muscle cell migration requires PI3-K and Akt activation.

  The Journal of surgical research 20050701

• Intracellular signal transduction pathways induced by leptin in C2C12 cells.

  Cell biology international 20050701

• Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus.

  Journal of neurophysiology 20050701

• Differential display analysis reveals the expression of glutathione S-transferase omega and novel genes through an ITAM-containing receptor in ascidian immunocytes.

  Immunogenetics 20050701

• Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism.

  Gastroenterology 20050701

• Characterization of the cloned full-length and a truncated human target of rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay.

  Biochemical and biophysical research communications 20050624

• Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.

  The Journal of biological chemistry 20050617

• Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism.

  Blood 20050615

• Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.

  Blood 20050615

• LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase.

  Immunology letters 20050615

• Protein kinase C-independent pathway for NADPH oxidase activation in guinea pig peritoneal polymorphonuclear leukocytes by cytochalasin D.

  Archives of biochemistry and biophysics 20050615

• Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.

  Toxicology and applied pharmacology 20050615

• Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation.

  The Journal of biological chemistry 20050610

• Characterization of heparin affin regulatory peptide signaling in human endothelial cells.

  The Journal of biological chemistry 20050610

• Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells.

  The Journal of biological chemistry 20050610

• Chemistry and biology of wortmannin.

  Organic & biomolecular chemistry 20050607

• Characterization of the protective effects of cardiotrophin-1 against non-ischemic death stimuli in adult cardiomyocytes.

  Cytokine 20050607

• Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.

  The Journal of biological chemistry 20050603

• Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway.

  Biochemical and biophysical research communications 20050603

• Extending the cardioprotective window using a novel delta-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway.

  American journal of physiology. Heart and circulatory physiology 20050601

• Endothelin-1 induces lipolysis in 3T3-L1 adipocytes.

  American journal of physiology. Endocrinology and metabolism 20050601

• Fructose-induced increases in neonatal rat intestinal fructose transport involve the PI3-kinase/Akt signaling pathway.

  American journal of physiology. Gastrointestinal and liver physiology 20050601

• Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin.

  American journal of physiology. Heart and circulatory physiology 20050601

• Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.

  The Biochemical journal 20050601

• Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells.

  Carcinogenesis 20050601

• Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression.

  Endocrinology 20050601

• Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension.

  The Journal of pharmacology and experimental therapeutics 20050601

• Renal cyclooxygenase-2 in obese Zucker (fatty) rats.

  Kidney international 20050601

• PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of beta1-adrenergic preconditioning.

  Cardiovascular research 20050601

• Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway.

  British journal of haematology 20050601

• Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell.

  Acta pharmacologica Sinica 20050601

• Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.

  Diabetes 20050601

• Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050601

• Hyposmolarity-induced ErbB4 phosphorylation and its influence on the non-receptor tyrosine kinase network response in cultured cerebellar granule neurons.

  Journal of neurochemistry 20050601

• Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050601

• Wortmannin elevates tumor necrosis factor-related apoptosis-inducing ligand sensitivity in LNCaP cells through down-regulation of IAP-2 protein.

  Experimental oncology 20050601

• The effect of epidermal growth factor on production of vascular endothelial growth factor by amnion-derived (WISH) cells.

  Growth factors (Chur, Switzerland) 20050601

• Actin-based motility of endosomes is linked to the polar tip growth of root hairs.

  European journal of cell biology 20050601

• Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase.

  Biochemical and biophysical research communications 20050527

• Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium.

  Circulation 20050524

• The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.

  British journal of cancer 20050523

• Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder.

  British journal of cancer 20050523

• Ras couples phosphoinositide 3-OH kinase to the epithelial Na+ channel.

  Biochimica et biophysica acta 20050520

• The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formation.

  Journal of the American College of Cardiology 20050517

• Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells.

  Blood 20050515

• Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking.

  Experimental cell research 20050515

• Role of lipoteichoic acid in the phagocyte response to group B streptococcus.

  Journal of immunology (Baltimore, Md. : 1950) 20050515

• Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8.

  The Journal of biological chemistry 20050513

• Quantitative aspects of endocytic activity in lipid-mediated transfections.

  FEBS letters 20050509

• A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.

  The Journal of biological chemistry 20050506

• Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway.

  The Journal of biological chemistry 20050506

• The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro.

  Biochemical and biophysical research communications 20050506

• Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells.

  Life sciences 20050506

• Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes.

  Oncogene 20050505

• Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction.

  Mutation research 20050502

• Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways.

  Basic research in cardiology 20050501

• Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils.

  American journal of physiology. Lung cellular and molecular physiology 20050501

• Activation of PI3-kinase/PKB contributes to delay in neutrophil apoptosis after thermal injury.

  American journal of physiology. Cell physiology 20050501

• Insulin-like growth factor-I induces oocyte maturational competence but not meiotic resumption in white bass (Morone chrysops) follicles in vitro: evidence for rapid evolution of insulin-like growth factor action.

  Biology of reproduction 20050501

• Cobalt chloride-induced estrogen receptor alpha down-regulation involves hypoxia-inducible factor-1alpha in MCF-7 human breast cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20050501

• Regulation of the muscarinic K+ channel by extracellular ATP through membrane phosphatidylinositol 4,5-bisphosphate in guinea-pig atrial myocytes.

  British journal of pharmacology 20050501

• Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.

  The Journal of biological chemistry 20050501

• Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor.

  Journal of the American Society of Nephrology : JASN 20050501

• Inhibition of protein-tyrosine phosphatases stimulates insulin secretion in pancreatic islets of diabetic Goto-Kakizaki rats.

  Pancreas 20050501

• Effects of melatonin on wortmannin-induced tau hyperphosphorylation.

  Acta pharmacologica Sinica 20050501

• Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells.

  Experimental hematology 20050501

• 5-HT receptors couple to activation of Akt, but not extracellular-regulated kinase (ERK), in cultured hippocampal neurons.

  Journal of neurochemistry 20050501

• Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation.

  Journal of leukocyte biology 20050501

• The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation.

  Cancer research 20050501

• Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells.

  Acta biochimica et biophysica Sinica 20050501

• Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.

  Gastroenterology 20050501

• Sustained Akt/PKB activation and transient attenuation of c-jun N-terminal kinase in the inhibition of apoptosis by IGF-1 in vascular smooth muscle cells.

  Apoptosis : an international journal on programmed cell death 20050501

• Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation.

  Cell research 20050501

• Clozapine prevents apoptosis and enhances receptor-dependent respiratory burst in human neutrophils.

  Die Pharmazie 20050501

• Angiotensin II stimulates hypoxia-inducible factor 1alpha accumulation in glomerular mesangial cells.

  Annals of the New York Academy of Sciences 20050501

• Possible involvement of phosphatidylinositol 3-kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050501

• Participation of protein kinases in the stimulant action of GLP-1 on 2-deoxy-D-glucose uptake by normal rat skeletal muscle.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050501

• Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid.

  Neurochemical research 20050501

• Phosphorylation of grb10 regulates its interaction with 14-3-3.

  The Journal of biological chemistry 20050429

• Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cells.

  Biochemical and biophysical research communications 20050429

• Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils.

  The Journal of biological chemistry 20050415

• Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha.

  FEBS letters 20050411

• Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important.

  The Journal of biological chemistry 20050408

• The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells.

  The Journal of biological chemistry 20050408

• Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.

  The Journal of biological chemistry 20050408

• The epidermal growth factor-pathway is not involved in down-regulation of Ca(2+)-induced Cl- secretion in rat distal colon.

  European journal of pharmacology 20050404

• Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K.

  The Prostate 20050401

• Novel and quantitative DNA dot-blotting method for assessment of in vivo proliferation.

  American journal of physiology. Gastrointestinal and liver physiology 20050401

• Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway.

  American journal of physiology. Heart and circulatory physiology 20050401

• 1,25-dihydroxyvitamin D(3) stimulated protein kinase C phosphorylation of type VI adenylyl cyclase inhibits parathyroid hormone signal transduction in rat osteoblastic UMR 106-01 cells.

  Journal of cellular biochemistry 20050401

• Relaxin stimulates protein kinase C zeta translocation: requirement for cyclic adenosine 3',5'-monophosphate production.

  Molecular endocrinology (Baltimore, Md.) 20050401

• Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury.

  The Journal of pharmacology and experimental therapeutics 20050401

• Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons.

  Molecular pharmacology 20050401

• Mechanisms of interleukin-4 effects on calcium signaling in airway smooth muscle cells.

  The Journal of pharmacology and experimental therapeutics 20050401

• PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.

  The Journal of physiology 20050401

• Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo.

  Circulation research 20050401

• Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.

  European journal of immunology 20050401

• Astrocyte growth effects of vascular endothelial growth factor (VEGF) application to perinatal neocortical explants: receptor mediation and signal transduction pathways.

  Experimental neurology 20050401

• Multiple pathways of apolipoprotein E signaling in primary neurons.

  Journal of neurochemistry 20050401

• Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1.

  Journal of immunology (Baltimore, Md. : 1950) 20050401

• Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line.

  Gynecologic oncology 20050401

• Nuclear factor-kappaB activation correlates with better prognosis and Akt activation in human gastric cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

• Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor.

  Haematologica 20050401

• Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death.

  Journal of pharmacological sciences 20050401

• Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution.

  Gastroenterology 20050401

• Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1alpha/CXCR4-mediated migration of epitheloid carcinoma cells.

  Molecular cancer research : MCR 20050401

• Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway.

  Placenta 20050401

• Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons.

  The European journal of neuroscience 20050401

• Urokinase-induced smooth muscle cell responses require distinct signaling pathways: a role for the epidermal growth factor receptor.

  Journal of vascular surgery 20050401

• Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth.

  Molecular and cellular biochemistry 20050401

• [Effect of wortmannin on endothelial cell proliferation and migration induced by high glucose Müller cell conditioned medium].

  Zhonghua bing li xue za zhi = Chinese journal of pathology 20050401

• Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide.

  Inflammation 20050401

• Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.

  Regulatory peptides 20050330

• Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050330

• Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines.

  British journal of cancer 20050328

• Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.

  European journal of pharmacology 20050328

• Regulation of CHK2 by DNA-dependent protein kinase.

  The Journal of biological chemistry 20050325

• Apoptosis of mink lung epithelial cells by co-treatment of low-dose staurosporine and transforming growth factor-beta1 depends on the enhanced TGF-beta signaling and requires the decreased phosphorylation of PKB/Akt.

  Biochemical and biophysical research communications 20050325

• Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases.

  The Journal of biological chemistry 20050318

• Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.

  European journal of pharmacology 20050314

• Inhibition of Src-like kinases reveals Akt-dependent and -independent pathways in insulin-like growth factor I-mediated oligodendrocyte progenitor survival.

  The Journal of biological chemistry 20050311

• Insulin-like growth factor-1 inhibits adult supraoptic neurons via complementary modulation of mechanoreceptors and glycine receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302

• Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML.

  Blood 20050301

• Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.

  Endocrinology 20050301

• The nongenotropic synthetic ligand 4-estren-3alpha17beta-diol is a high-affinity genotropic androgen receptor agonist.

  Molecular pharmacology 20050301

• Transfected beta3- but not beta2-adrenergic receptors regulate cystic fibrosis transmembrane conductance regulator activity via a new pathway involving the mitogen-activated protein kinases extracellular signal-regulated kinases.

  Molecular pharmacology 20050301

• Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity.

  Cellular signalling 20050301

• Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways.

  Molecular pharmacology 20050301

• Dose-dependent insulin regulation of insulin-like growth factor binding protein-1 in human endometrial stromal cells is mediated by distinct signaling pathways.

  The Journal of clinical endocrinology and metabolism 20050301

• Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylation.

  The international journal of biochemistry & cell biology 20050301

• HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301

• Interferon alpha 2a down-regulates VEGF expression through PI3 kinase and MAP kinase signaling pathways.

  Journal of cancer research and clinical oncology 20050301

• Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress.

  Free radical biology & medicine 20050301

• Sucrose-inducible endocytosis as a mechanism for nutrient uptake in heterotrophic plant cells.

  Plant & cell physiology 20050301

• Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells.

  International journal of molecular medicine 20050301

• Differential regulation by protein kinases of activity and cell surface expression of glutamate transporters in neuron-enriched cultures.

  Neurochemistry international 20050301

• Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.

  Journal of neurochemistry 20050301

• Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes.

  Cardiovascular research 20050301

• Atorvastatin and myocardial reperfusion injury: new pleiotropic effect implicating multiple prosurvival signaling.

  Journal of cardiovascular pharmacology 20050301

• Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK.

  Journal of immunology (Baltimore, Md. : 1950) 20050301

• Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13.

  Investigative ophthalmology & visual science 20050301

• Oxidized low-density lipoprotein-induced apoptosis is attenuated by insulin-activated phosphatidylinositol 3-kinase/Akt through p38 mitogen-activated protein kinase.

  Clinical and experimental pharmacology & physiology 20050301

• Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.

  The American journal of pathology 20050301

• Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

  PLoS biology 20050301

• Functional proteins involved in regulation of intracellular Ca(2+) for drug development: role of calcium/calmodulin-dependent protein kinases in ischemic neuronal death.

  Journal of pharmacological sciences 20050301

• The role of acidic organelles in the development of schistosomula of Schistosoma mansoni and their response to signalling molecules.

  Parasitology 20050301

• Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation.

  Journal of vascular surgery 20050301

• Fenofibrate induces apoptotic injury in cultured human hepatocytes by inhibiting phosphorylation of Akt.

  Apoptosis : an international journal on programmed cell death 20050301

• Effects of FSH and 17beta-estradiol on the transactivation of estrogen-regulated promoters and cell proliferation in L cells.

  The Journal of steroid biochemistry and molecular biology 20050301

• PI3K/AKT is involved in mediating survival signals that rescue Ewing tumour cells from fibroblast growth factor 2-induced cell death.

  British journal of cancer 20050227

• Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells.

  Biochemical and biophysical research communications 20050225

• Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

• Effect of Wortmannin on the repair profiles of DNA double-strand breaks in the whole genome and in interstitial telomeric sequences of Chinese hamster cells.

  Mutation research 20050215

• In vivo effects of protein kinase and phosphatase inhibitors on CYP2B induction in rat liver.

  Toxicology 20050214

• Auxin-induced reactive oxygen species production requires the activation of phosphatidylinositol 3-kinase.

  FEBS letters 20050214

• Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes.

  The Journal of biological chemistry 20050211

• Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.

  The Journal of biological chemistry 20050211

• Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes.

  The Journal of biological chemistry 20050211

• A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.

  The Journal of biological chemistry 20050211

• Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy.

  Oncogene 20050210

• Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells.

  Journal of cellular physiology 20050201

• Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.

  Journal of cellular physiology 20050201

• Abrogation of apoptosis through PDGF-BB-induced sulfated glycosaminoglycan synthesis and secretion.

  American journal of physiology. Lung cellular and molecular physiology 20050201

• Sustained diacylglycerol accumulation resulting from prolonged G protein-coupled receptor agonist-induced phosphoinositide breakdown in hepatocytes.

  Journal of cellular biochemistry 20050201

• The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols.

  Carcinogenesis 20050201

• Autocrine regulation of insulin secretion in human ejaculated spermatozoa.

  Endocrinology 20050201

• Low proliferation and high apoptosis of osteoblastic cells on hydrophobic surface are associated with defective Ras signaling.

  Experimental cell research 20050201

• Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection.

  Cell death and differentiation 20050201

• Differential effect of insulin and elevated glucose level on adenosine transport in rat B lymphocytes.

  International immunology 20050201

• Insulin enhanced thrombin-activable fibrinolysis inhibitor expression through PI3 kinase/Akt pathway.

  International journal of molecular medicine 20050201

• Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production.

  British journal of pharmacology 20050201

• Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats.

  Journal of hypertension 20050201

• Rosiglitazone treatment in Zucker diabetic Fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury.

  Diabetes 20050201

• Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization.

  The Journal of clinical investigation 20050201

• PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung.

  Tissue & cell 20050201

• Nitric oxide stimulates 18F-FDG uptake in human endothelial cells through increased hexokinase activity and GLUT1 expression.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050201

• Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1.

  Cancer research 20050201

• Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.

  The Journal of biological chemistry 20050128

• Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

  Journal of medicinal chemistry 20050127

• Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner.

  The Journal of biological chemistry 20050121

• Calcium-pH crosstalks in rat mast cells: modulation by transduction signals show non-essential role for calcium in alkaline-induced exocytosis.

  Biochemical pharmacology 20050115

• Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

  Chemico-biological interactions 20050115

• Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050115

• Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors.

  The Journal of biological chemistry 20050114

• Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

  The Journal of biological chemistry 20050114

• Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112

• Wortmannin inhibits the myofilament Ca2+ sensitization induced by endothelin-1.

  European journal of pharmacology 20050110

• Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria.

  Blood 20050101

• Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex.

  Molecular endocrinology (Baltimore, Md.) 20050101

• Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects.

  Molecular pharmacology 20050101

• Peroxynitrite activates glucose uptake in 3T3-L1 adipocytes through a PI3-K-dependent mechanism.

  Frontiers in bioscience : a journal and virtual library 20050101

• Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells.

  International journal of oncology 20050101

• Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling.

  Molecular and cellular neurosciences 20050101

• Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation.

  Basic research in cardiology 20050101

• Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity.

  Diabetes 20050101

• Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits.

  Anesthesiology 20050101

• Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium.

  Cardiovascular research 20050101

• Regulation of taurocholate transport in freshly isolated proximal tubular cells of the rat kidney by protein kinases.

  Nephron. Physiology 20050101

• Receptor salvage from the prevacuolar compartment is essential for efficient vacuolar protein targeting.

  The Plant cell 20050101

• Protective effects of insulin during ischemia-reperfusion injury in hamster cheek pouch microcirculation.

  Journal of vascular research 20050101

• Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.

  Arthritis research & therapy 20050101

• Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

  Chemistry & biology 20050101

• TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101

• Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin.

  Journal of vascular surgery 20050101

• Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.

  Arthritis research & therapy 20050101

• Burkholderia pseudomallei invasion and activation of epithelial cells requires activation of p38 mitogen-activated protein kinase.

  Microbial pathogenesis 20050101

• Effects of the tyrosine kinase inhibitor imatinib on neuroendocrine tumor cell growth.

  Digestion 20050101

• Contribution of the PI 3-kinase/Akt survival pathway toward osmotic preconditioning.

  Molecular and cellular biochemistry 20050101

• Effect of prostaglandin E2 on PMA-induced macrophage differentiation.

  Prostaglandins & other lipid mediators 20050101

• Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells.

  BMC gastroenterology 20050101

• Blockage of cyclin cdk's, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: evidence for interactive effects of flavopiridol, LY 294002, roscovitine,wortmannin and UCN-01.

  Anticancer research 20050101

• Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells.

  Neuroscience 20050101

• Sensitization and translocation of TRPV1 by insulin and IGF-I.

  Molecular pain 20050101

• Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts.

  Cardiovascular drugs and therapy 20050101

• CD40-dependent activation of phosphatidylinositol 3-kinase/AKT pathway inhibits apoptosis of human cultured mesangial cells induced by oxidized LDL.

  International journal of immunopathology and pharmacology 20050101

• Synthesis and activity of C11-modified wortmannin probes for PI3 kinase.

  Bioconjugate chemistry 20050101

• Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1.

  Arthritis research & therapy 20050101

• Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils.

  Journal of biomedical science 20050101

• Calcium oscillation and phosphatidylinositol 3-kinase positively regulate integrin alpha(IIb)beta3-mediated outside-in signaling.

  Journal of biomedical science 20050101

• Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala.

  Neuroscience 20050101

• PI3K and PKC contribute to membrane depolarization mediated by alpha2-adrenoceptors in the canine isolated mesenteric vein.

  BMC physiology 20050101

• A sentence sliding window approach to extract protein annotations from biomedical articles.

  BMC bioinformatics 20050101

• H2O2-induced phosphorylation of ERK1/2 and PKB requires tyrosine kinase activity of insulin receptor and c-Src.

  Antioxidants & redox signaling 20050101

• The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism.

  BMC cancer 20050101

• Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets.

  Platelets 20050101

• Effects of pulsatile shear stress on signaling mechanisms controlling nitric oxide production, endothelial nitric oxide synthase phosphorylation, and expression in ovine fetoplacental artery endothelial cells.

  Endothelium : journal of endothelial cell research 20050101

• Pharmacologic profiling of transcriptional targets deciphers promoter logic.

  The pharmacogenomics journal 20050101

• Ras initiates phosphatidyl-inositol-3-kinase (PI3K)/PKB mediated signalling pathways in untransformed human peripheral blood T lymphocytes.

  Advances in enzyme regulation 20050101

• Endothelial cell injury by high glucose and heparanase is prevented by insulin, heparin and basic fibroblast growth factor.

  Cardiovascular diabetology 20050101

• Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.

  Journal of biomedical science 20050101

• Carbamazepine enhances the activity of glutamate transporter type 3 via phosphatidylinositol 3-kinase.

  Epilepsy research 20050101

• The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks.

  BMC molecular biology 20050101

• Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL.

  Immunobiology 20050101

• Se-methylselenocysteine inhibits phosphatidylinositol 3-kinase activity of mouse mammary epithelial tumor cells in vitro.

  Breast cancer research : BCR 20050101

• Understanding endocrine resistance: the critical need for sequential samples from clinical breast cancer and novel in vitro models.

  Breast cancer research : BCR 20050101

• Inward relocation of exogenous phosphatidylserine triggered by IGF-1 in non-apoptotic C2C12 cells is concentration dependent.

  Cell biochemistry and function 20050101

• Effect of GSK-3 overactivation on neurofilament phosphorylation.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

• Systems biology approaches in cell signaling research.

  Genome biology 20050101

• BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through PI3K/Akt-mediated NF-kappaB activation.

  Journal of bone and mineral metabolism 20050101

• Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.

  Respiratory research 20050101

• Angiopoietin-1 reduces iopromide-induced endothelial cell apoptosis through activation of phosphatidylinositol 3'-kinase/p70 S6 kinase.

  International journal of tissue reactions 20050101

• Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle.

  Cell structure and function 20050101

• Effects of small molecules on chaperone-mediated autophagy.

  Autophagy 20050101

• Vascular endothelial cell growth factor attenuates actions of transforming growth factor-beta in human endothelial cells.

  The Journal of biological chemistry 20041231

• On the mechanism for neomycin reversal of wortmannin inhibition of insulin stimulation of glucose uptake.

  The Journal of biological chemistry 20041231

• A positive role of the PI3-K/Akt signaling pathway in PC12 cell differentiation.

  Molecules and cells 20041231

• Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.

  The Journal of biological chemistry 20041217

• WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.

  Oncogene 20041216

• Role of cell signalling involved in induction of apoptosis by benzo[a]pyrene and cyclopenta[c,d]pyrene in Hepa1c1c7 cells.

  Journal of cellular biochemistry 20041215

• Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.

  The Biochemical journal 20041215

• Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation.

  Journal of cell science 20041215

• Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor.

  The Journal of biological chemistry 20041210

• Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity.

  Biochemical and biophysical research communications 20041210

• Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

  Circulation research 20041210

• Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041208

• Regulation of cardiac IKs potassium current by membrane phosphatidylinositol 4,5-bisphosphate.

  The Journal of biological chemistry 20041203

• Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase.

  American journal of physiology. Gastrointestinal and liver physiology 20041201

• Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP.

  American journal of physiology. Heart and circulatory physiology 20041201

• Membrane retrieval in neutrophils during phagocytosis: inhibition by M protein-expressing S. pyogenes bacteria.

  Journal of leukocyte biology 20041201

• Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Insulin-like growth factor-i regulation of hepatic scavenger receptor class BI.

  Endocrinology 20041201

• Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells.

  Endocrinology 20041201

• Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201

• Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201

• Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma.

  Laboratory investigation; a journal of technical methods and pathology 20041201

• Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells.

  Biochemical pharmacology 20041201

• Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model.

  Hypertension (Dallas, Tex. : 1979) 20041201

• Inhibition of myosin light chain kinase provides prolonged attenuation of radial artery vasospasm.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20041201

• Pathophysiological concentrations of amyloid beta proteins directly inhibit rat brain and recombinant human type II phosphatidylinositol 4-kinase activity.

  Journal of neurochemistry 20041201

• Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways.

  Journal of neurochemistry 20041201

• Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells.

  European journal of cancer (Oxford, England : 1990) 20041201

• Possible role of phosphatidylinositol 4,5 bisphosphate in luteinizing hormone releasing hormone-mediated M-current inhibition in bullfrog sympathetic neurons.

  The European journal of neuroscience 20041201

• Prostaglandin E2 mediates phosphorylation and down-regulation of the tuberous sclerosis-2 tumor suppressor (tuberin) in human endometrial adenocarcinoma cells via the Akt signaling pathway.

  The Journal of clinical endocrinology and metabolism 20041201

• c-Myc protein is stabilized by fibroblast growth factor 2 and destabilized by ACTH to control cell cycle in mouse Y1 adrenocortical cells.

  Journal of molecular endocrinology 20041201

• Activation of c-kit by stem cell factor induces radioresistance to apoptosis through ERK-dependent expression of survivin in HL60 cells.

  Journal of radiation research 20041201

• Activation of human neutrophils by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha: role of phosphatidylinositol 3-kinase.

  International journal of hematology 20041201

• Exogenous tissue inhibitor of metalloproteinase-1 promotes endothelial cell survival through activation of the phosphatidylinositol 3-kinase/Akt pathway.

  Annals of the New York Academy of Sciences 20041201

• Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20041201

• Induction of genes involved in cell cycle progression by interleukin-4.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20041201

• Ligand-independent activation of peroxisome proliferator-activated receptor-gamma by insulin and C-peptide in kidney proximal tubular cells: dependent on phosphatidylinositol 3-kinase activity.

  The Journal of biological chemistry 20041126

• Inhibition of wortmannin activities by amino compounds.

  Biochemical and biophysical research communications 20041126

• Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells.

  Biochemical and biophysical research communications 20041119

• Overexpression of transglutaminase 2 accelerates the erythroid differentiation of human chronic myelogenous leukemia K562 cell line through PI3K/Akt signaling pathway.

  FEBS letters 20041119

• Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways.

  FEBS letters 20041119

• Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.

  Journal of cellular biochemistry 20041115

• Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041115

• 3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent.

  The Journal of biological chemistry 20041112

• Aspects of the early moments of interaction between tachyzoites of Toxoplasma gondii with neutrophils.

  Veterinary parasitology 20041110

• Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium.

  American journal of physiology. Heart and circulatory physiology 20041101

• The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.

  The Journal of pharmacology and experimental therapeutics 20041101

• LY-294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects calcium signaling in airway smooth muscle cells independently of phosphoinositide 3-kinase inhibition.

  The Journal of pharmacology and experimental therapeutics 20041101

• Primary granule release from human neutrophils is potentiated by soluble fibrinogen through a mechanism depending on multiple intracellular signaling pathways.

  American journal of physiology. Cell physiology 20041101

• Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism.

  American journal of respiratory cell and molecular biology 20041101

• Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines.

  Endocrinology 20041101

• Leptin inhibits lysophosphatidic acid-induced intracellular calcium rise by a protein kinase C-dependent mechanism.

  Journal of cellular physiology 20041101

• PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.

  European journal of immunology 20041101

• Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks.

  Experimental cell research 20041101

• Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes.

  The Journal of investigative dermatology 20041101

• HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway.

  Journal of neurochemistry 20041101

• BCR activation of PI3K is Vav-independent in murine B cells.

  Biochemical Society transactions 20041101

• Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes.

  Journal of molecular and cellular cardiology 20041101

• Comparative effects of amino acids and glucose on insulin secretion from isolated rat or mouse islets.

  The Journal of endocrinology 20041101

• Phosphatidylinositol-3-kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to beta1-integrins in human CD34+ cells.

  Experimental hematology 20041101

• Transforming growth factor-beta 1-induced apoptosis is blocked by beta 1-integrin-mediated mitogen-activated protein kinase activation in human hepatoma cells.

  Cancer science 20041101

• [Effects of basic fibroblast growth factor on protein kinase B activity and c-fos expression in CNE- I nasopharyngeal carcinoma cell line].

  Zhonghua er bi yan hou ke za zhi 20041101

• Signal transduction of ET-1 in contraction of cerebral arteries.

  Journal of cardiovascular pharmacology 20041101

• Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.

  The Journal of biological chemistry 20041029

• DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation.

  Biochemical and biophysical research communications 20041022

• Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer.

  British journal of cancer 20041018

• Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.

  Journal of cellular biochemistry 20041015

• Insulin feedback actions: complex effects involving isoforms of islet nitric oxide synthase.

  Regulatory peptides 20041015

• Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line.

  Journal of cell science 20041015

• The magnitude of Akt/phosphatidylinositol 3'-kinase proliferating signaling is related to CD45 expression in human myeloma cells.

  Journal of immunology (Baltimore, Md. : 1950) 20041015

• Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase.

  Cancer research 20041015

• Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase.

  Circulation 20041012

• Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells.

  Journal of applied physiology (Bethesda, Md. : 1985) 20041001

• Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation.

  American journal of physiology. Heart and circulatory physiology 20041001

• Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes.

  The Journal of pharmacology and experimental therapeutics 20041001

• Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets.

  Endocrinology 20041001

• The effect of phosphoinositide 3-kinase inhibitors on programmed nuclear degradation in Tetrahymena and fate of surviving nuclei.

  Cell death and differentiation 20041001

• Oestradiol rapidly inhibits Ca2+ signals in ciliary neurons through classical oestrogen receptors in cytoplasm.

  Pflugers Archiv : European journal of physiology 20041001

• Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells.

  The Journal of physiology 20041001

• Carbon monoxide protects against cardiac ischemia--reperfusion injury in vivo via MAPK and Akt--eNOS pathways.

  Arteriosclerosis, thrombosis, and vascular biology 20041001

• C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages.

  International immunopharmacology 20041001

• Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

  Arteriosclerosis, thrombosis, and vascular biology 20041001

• PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.

  Arteriosclerosis, thrombosis, and vascular biology 20041001

• The effect of insulin-like growth factor-I on production of vascular endothelial growth factor by amnion-derived (WISH) cells.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20041001

• 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling.

  Circulation research 20041001

• Nitric oxide-dependent beta2-adrenergic dilatation of rat aorta is mediated through activation of both protein kinase A and Akt.

  British journal of pharmacology 20041001

• Basal prostate epithelial cells stimulate the migration of prostate cancer cells.

  Molecular carcinogenesis 20041001

• HGF protects corneal epithelial cells from apoptosis by the PI-3K/Akt-1/Bad- but not the ERK1/2-mediated signaling pathway.

  Investigative ophthalmology & visual science 20041001

• Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival.

  Investigative ophthalmology & visual science 20041001

• A beta-tubulin mutation selectively uncouples nuclear division and cytokinesis in Tetrahymena thermophila.

  Eukaryotic cell 20041001

• Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance.

  European journal of clinical investigation 20041001

• Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis.

  Gastroenterology 20041001

• Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation.

  Journal of pharmacological sciences 20041001

• The effect of anionic amphiphiles on the recruitment of Rac in neutrophils.

  Journal of biochemistry 20041001

• Role of phosphatidylinositol-3-kinase and protein kinase C zeta in the adenylate cyclase signal mechanism of action of relaxin in muscle tissues of rats and mollusks.

  Bulletin of experimental biology and medicine 20041001

• Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

  The EMBO journal 20040929

• Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040922

• Mechanisms of hydroxyl radical-induced contraction of rat aorta.

  European journal of pharmacology 20040919

• Regulation of Gene33 expression by insulin requires MEK-ERK activation.

  Biochimica et biophysica acta 20040917

• Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.

  The Biochemical journal 20040915

• Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.

  European journal of pharmacology 20040913

• ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.

  Biochemical and biophysical research communications 20040910

• Insulin induces alpha1B-adrenergic receptor phosphorylation and desensitization.

  Life sciences 20040903

• In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent.

  Biology of reproduction 20040901

• Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20040901

• Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning.

  American journal of physiology. Heart and circulatory physiology 20040901

• Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and phosphatidylinositol 3-kinase-dependent pathway.

  Endocrinology 20040901

• V-type ATPase is involved in biogenesis of GLUT4 vesicles.

  American journal of physiology. Endocrinology and metabolism 20040901

• A novel function of insulin in rat dermis.

  The Journal of physiology 20040901

• Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration.

  Molecular human reproduction 20040901

• Beryllium-specific immune response in primary cells from healthy individuals.

  Toxicology 20040901

• Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.

  Cardiovascular research 20040901

• p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes.

  Basic research in cardiology 20040901

• The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.

  Journal of neurochemistry 20040901

• Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion.

  Apoptosis : an international journal on programmed cell death 20040901

• Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition.

  Apoptosis : an international journal on programmed cell death 20040901

• ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells.

  American journal of physiology. Heart and circulatory physiology 20040901

• YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells.

  Molecular pharmacology 20040901

• The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.

  PLoS biology 20040901

• The small GTPase Rac is involved in clustering of hippocampal neurons and fasciculation of their neurites.

  Naunyn-Schmiedeberg's archives of pharmacology 20040901

• Pneumolysin potentiates oxidative inactivation of alpha-1-proteinase inhibitor by activated human neutrophils.

  Respiratory medicine 20040901

• Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1.

  Acta pharmacologica Sinica 20040901

• Effects of muscarinic acetylcholine receptor activation on membrane currents and intracellular messengers in medium spiny neurones of the rat striatum.

  The European journal of neuroscience 20040901

• Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin.

  The Journal of clinical investigation 20040901

• Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.

  Bioorganic & medicinal chemistry 20040901

• Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.

  Gastroenterology 20040901

• Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901

• Influence of hypotonic shock on glutamate and GABA uptake in rat brain synaptosomes.

  Neurochemical research 20040901

• Estrogen induced changes in Akt-dependent activation of endothelial nitric oxide synthase and vasodilation.

  Steroids 20040901

• Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway.

  Journal of cardiovascular pharmacology 20040901

• Hypergravity induces phosphorylation of p53 at serine 15, but not an expression of p53-downstream genes.

  Journal of radiation research 20040901

• Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.

  Circulation 20040831

• Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor.

  Biochemical and biophysical research communications 20040827

• Antiapoptotic effect of ouabain on human umbilical vein endothelial cells.

  Biochemical and biophysical research communications 20040827

• Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation.

  The Journal of biological chemistry 20040820

• Signaling pathways required for matrix metalloproteinase-9 induction by betacellulin in head-and-neck squamous carcinoma cells.

  International journal of cancer 20040820

• Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.

  Circulation research 20040820

• Activation of MAP kinase by MC4-R through PI3 kinase.

  Regulatory peptides 20040815

• Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.

  Regulatory peptides 20040815

• Muscarinic modulation of erg potassium current.

  The Journal of physiology 20040815

• Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain.

  Journal of cell science 20040815

• Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.

  Journal of immunology (Baltimore, Md. : 1950) 20040815

• Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.

  The Journal of biological chemistry 20040813

• Facilitated detection of chromosome break and repair at low levels of ionizing radiation by addition of wortmannin to G1-type PCC fusion incubation.

  Mutation research 20040808

• Postconditioning: a form of 'modified reperfusion' protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway.

  Circulation research 20040806

• Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5-trisphosphate.

  Circulation research 20040806

• Rapid up-regulation of endothelial nitric-oxide synthase in a mouse model of Escherichia coli lipopolysaccharide-induced bladder inflammation.

  The Journal of pharmacology and experimental therapeutics 20040801

• Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors.

  American journal of physiology. Heart and circulatory physiology 20040801

• Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90.

  American journal of physiology. Renal physiology 20040801

• Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils.

  Journal of leukocyte biology 20040801

• Endothelin stimulates endothelial nitric oxide synthase expression in the thick ascending limb.

  American journal of physiology. Renal physiology 20040801

• Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments.

  Arteriosclerosis, thrombosis, and vascular biology 20040801

• The interleukin-6/soluble interleukin-6 receptor system induces parathyroid hormone-related protein in human osteoblastic cells.

  Calcified tissue international 20040801

• Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epithelium.

  Laboratory investigation; a journal of technical methods and pathology 20040801

• PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation.

  Journal of cellular physiology 20040801

• Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas.

  Laboratory investigation; a journal of technical methods and pathology 20040801

• Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines.

  Cancer biology & therapy 20040801

• The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801

• Prosaposin: a new player in cell death prevention of U937 monocytic cells.

  Experimental cell research 20040801

• Insulin reduces apoptosis and increases DNA synthesis and cell size via distinct signalling pathways in Drosophila Kc cells.

  Cell proliferation 20040801

• Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathway.

  British journal of pharmacology 20040801

• Rapid vesicular translocation and insertion of TRP channels.

  Nature cell biology 20040801

• Macrophage colony-stimulating factor-, granulocyte-macrophage colony-stimulating factor-, or IL-3-dependent survival of macrophages, but not proliferation, requires the expression of p21(Waf1) through the phosphatidylinositol 3-kinase/Akt pathway.

  European journal of immunology 20040801

• Continuous phosphatidylinositol metabolism is required for cleavage of crane fly spermatocytes.

  Journal of cell science 20040801

• Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK.

  American journal of physiology. Heart and circulatory physiology 20040801

• Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity.

  European journal of biochemistry 20040801

• Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway.

  European journal of endocrinology 20040801

• Inhibition of alpha5 integrin decreases PI3K activation and cell adhesion of human colon cancers.

  Surgery 20040801

• The regulation of integrin-linked kinase in human platelets: evidence for involvement in the regulation of integrin alpha 2 beta 1.

  Journal of thrombosis and haemostasis : JTH 20040801

• Insulin regulates the expression of the enhancer of split- and hairy-related protein-2 gene via different pathways in 3T3-L1 adipocytes and L6 myotubes.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040801

• Pharmacological inhibition of DNA repair enzymes differentially modulates telomerase activity and apoptosis in two human leukaemia cell lines.

  International journal of radiation biology 20040801

• [Effect of IGF-1 on PI3K/PTEN signal pathway in vascular smooth muscle cell].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20040801

• Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway.

  The Journal of biological chemistry 20040730

• Roles of cyclin-dependent kinase 4 and p53 in neuronal cell death induced by doxorubicin on cerebellar granule neurons in mouse.

  Neuroscience letters 20040729

• Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.

  The Journal of biological chemistry 20040723

• Characterization of H2O2-induced acute apoptosis in cultured neural stem/progenitor cells.

  FEBS letters 20040716

• Effects of phosphoinositide 3-kinase on endothelin-1-induced activation of voltage-independent Ca2+ channels and vasoconstriction.

  Biochemical pharmacology 20040715

• Performance in long-term memory tasks is augmented by a phosphorylated growth factor receptor fragment.

  Journal of neuroscience research 20040715

• Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.

  Experimental cell research 20040715

• Taurine prevents streptozotocin impairment of hormone-stimulated glucose uptake in rat adipocytes.

  European journal of pharmacology 20040714

• Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040714

• Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin.

  Organic & biomolecular chemistry 20040707

• Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.

  DNA repair 20040702

• Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle.

  Journal of applied physiology (Bethesda, Md. : 1985) 20040701

• Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death.

  American journal of physiology. Lung cellular and molecular physiology 20040701

• Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils.

  Cellular signalling 20040701

• Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040701

• HER2 signaling enhances 5'UTR-mediated translation of c-Myc mRNA.

  Journal of cellular physiology 20040701

• ATP priming of macrophage-derived chemokine responses in CHO cells expressing the CCR4 receptor.

  Naunyn-Schmiedeberg's archives of pharmacology 20040701

• Modulations of shear stress-induced contractile responses and agonist-induced vasodilation in hypercholesterolemic rats.

  Atherosclerosis 20040701

• Glucose activates H(+)-ATPase in kidney epithelial cells.

  American journal of physiology. Cell physiology 20040701

• Intracellular signalling and cytoskeletal rearrangement involved in Yersinia pestis plasminogen activator (Pla) mediated HeLa cell invasion.

  Microbial pathogenesis 20040701

• Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells.

  Experimental cell research 20040701

• Backup pathways of NHEJ are suppressed by DNA-PK.

  Journal of cellular biochemistry 20040701

• Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-kappaB activation and cyclooxygenase-2 expression in mesangial cells.

  Molecular pharmacology 20040701

• Manganese-induced integrin affinity maturation promotes recruitment of alpha V beta 3 integrin to focal adhesions in endothelial cells: evidence for a role of phosphatidylinositol 3-kinase and Src.

  Thrombosis and haemostasis 20040701

• ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

  Journal of cell science 20040701

• Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants.

  Biophysical journal 20040701

• Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling.

  Molecular cancer therapeutics 20040701

• Erk1/2 and Akt kinases are involved in the protective effect of aniracetam in astrocytes subjected to simulated ischemia in vitro.

  European journal of pharmacology 20040628

• Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis.

  Circulation research 20040625

• The action mechanism of zinc(II) complexes with insulinomimetic activity in rat adipocytes.

  Life sciences 20040625

• Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB.

  Biochemical and biophysical research communications 20040625

• eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.

  Biochemical and biophysical research communications 20040625

• Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis.

  Journal of immunology (Baltimore, Md. : 1950) 20040615

• ERK1/2 mediates insulin stimulation of Na(+),K(+)-ATPase by phosphorylation of the alpha-subunit in human skeletal muscle cells.

  The Journal of biological chemistry 20040611

• Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38.

  Brain research 20040611

• Intracellular trafficking and degradation of unassociated proalpha2 chains of collagen type I.

  Experimental cell research 20040610

• Signal transduction pathways that contribute to CDK1/cyclin B activation during the first mitotic division in sea urchin embryos.

  Experimental cell research 20040610

• Experimental evidence for the limiting role of enzymatic reactions in chemoattractant-induced pseudopod extension in human neutrophils.

  The Journal of biological chemistry 20040604

• Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.

  The Journal of biological chemistry 20040604

• Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction.

  Journal of leukocyte biology 20040601

• Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer.

  Endocrinology 20040601

• Constitutively activated phosphatidylinositol 3-kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation.

  Leukemia 20040601

• Na+/Mg2+ exchange is functionally coupled to the insulin receptor.

  Journal of cellular physiology 20040601

• Ang II attenuates IGF-1-stimulated Na+, K(+)-ATPase activity via PI3K/Akt pathway in vascular smooth muscle cells.

  International journal of molecular medicine 20040601

• Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process.

  Molecular pharmacology 20040601

• Regulation of granulocyte apoptosis by phosphatidylinositol 3-kinase.

  Biochemical Society transactions 20040601

• The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents.

  Cardiovascular research 20040601

• Basic fibroblast growth factor inhibits radiation-induced apoptosis of HUVECs. I. The PI3K/AKT pathway and induction of phosphorylation of BAD.

  Radiation research 20040601

• Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells.

  Diabetologia 20040601

• Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: role of phosphatidylinositol 3-kinase/Akt pathway.

  Journal of cardiovascular pharmacology 20040601

• Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells.

  Experimental hematology 20040601

• Orthovanadate stimulates cAMP phosphodiesterase 3 activity in isolated rat hepatocytes through mitogen-activated protein kinase activation dependent on cAMP-dependent protein kinase.

  Biological & pharmaceutical bulletin 20040601

• The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons.

  Neurochemistry international 20040601

• Leptin decreases renal medullary Na(+), K(+)-ATPase activity through phosphatidylinositol 3-kinase dependent mechanism.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040601

• Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.

  Metabolic brain disease 20040601

• Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells.

  Molecular cancer research : MCR 20040601

• Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat.

  Molecular and cellular biochemistry 20040601

• Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes.

  Molecular and cellular biochemistry 20040601

• Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway.

  The Journal of biological chemistry 20040528

• Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity.

  The Journal of biological chemistry 20040521

• Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.

  Biochemical and biophysical research communications 20040521

• Effects of wortmannin and latrunculin A on slow endocytosis at the frog neuromuscular junction.

  The Journal of physiology 20040515

• Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex.

  The Journal of biological chemistry 20040514

• Membrane-delimited regulation of novel background K+ channels by MgATP in murine immature B cells.

  The Journal of biological chemistry 20040514

• Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes.

  The Journal of biological chemistry 20040514

• A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells.

  Oncogene 20040513

• Brain-derived neurotrophic factor signalling in adult pig retinal ganglion cell neurite regeneration in vitro.

  Brain research 20040508

• Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.

  The Journal of biological chemistry 20040507

• Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK.

  The Journal of biological chemistry 20040507

• Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury.

  Circulation 20040504

• Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration.

  Neurochemistry international 20040501

• Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock.

  Journal of cellular physiology 20040501

• Lipoteichoic acid-stimulated p42/p44 MAPK activation via Toll-like receptor 2 in tracheal smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20040501

• Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.

  International journal of oncology 20040501

• IGF-I increases IGFBP-5 and collagen alpha1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells.

  American journal of physiology. Gastrointestinal and liver physiology 20040501

• Acid-base effects on intestinal Cl- absorption and vesicular trafficking.

  American journal of physiology. Cell physiology 20040501

• Brain-derived neurotrophic factor-, epidermal growth factor-, or A-Raf-induced growth of HaCaT keratinocytes requires extracellular signal-regulated kinase.

  American journal of physiology. Cell physiology 20040501

• Augmentation of lipolysis in adipocytes from fed rats, but not from starved rats, by inhibition of rolipram-sensitive phosphodiesterase 4.

  Archives of biochemistry and biophysics 20040501

• Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling.

  Journal of neurochemistry 20040501

• Role of ERK and Rho kinase pathways in central pressor action of urotensin II.

  Journal of hypertension 20040501

• In vitro metabolism of the phosphatidylinositol 3-kinase inhibitor, wortmannin, by carbonyl reductase.

  Drug metabolism and disposition: the biological fate of chemicals 20040501

• Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease.

  Annals of neurology 20040501

• Characterization of Tollip protein upon Lipopolysaccharide challenge.

  Molecular immunology 20040501

• Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells.

  British journal of haematology 20040501

• Hydrogen peroxide in the Burkitt's lymphoma cell line Raji provides protection against arsenic trioxide-induced apoptosis via the phosphoinositide-3 kinase signalling pathway.

  British journal of haematology 20040501

• The potential signalling pathways which regulate surface changes induced by phytohormones in the potato cyst nematode (Globodera rostochiensis).

  Parasitology 20040501

• Initial stages of low-temperature induction of cabbage cold shock protein gene csp5.

  Biochemistry. Biokhimiia 20040501

• Stem cell factor/c-kit signaling promotes the survival, migration, and capillary tube formation of human umbilical vein endothelial cells.

  The Journal of biological chemistry 20040430

• Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta.

  The Journal of biological chemistry 20040430

• G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning.

  Circulation research 20040430

• Hemangiopoietin inhibits apoptosis of MO7e leukemia cells through phosphatidylinositol 3-kinase-AKT pathway.

  Biochemical and biophysical research communications 20040423

• Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts.

  Circulation research 20040416

• Reconstituted high-density lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3-kinase but not Akt/endothelial nitric oxide synthase.

  Circulation research 20040416

• Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition.

  Biochemical and biophysical research communications 20040416

• TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis.

  Journal of cellular biochemistry 20040415

• Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis.

  Blood 20040415

• Ca2+ and phosphatidylinositol 4,5-bisphosphate stabilize a Gbeta gamma-sensitive state of Ca V2 Ca 2+ channels.

  The Journal of biological chemistry 20040409

• DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.

  The Journal of biological chemistry 20040409

• Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.

  Biochemical and biophysical research communications 20040409

• 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN.

  Biochemical and biophysical research communications 20040409

• Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1.

  European journal of pharmacology 20040405

• PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

  The Journal of biological chemistry 20040402

• TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes.

  Biochemical and biophysical research communications 20040402

• Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK.

  American journal of physiology. Heart and circulatory physiology 20040401

• A bronchial epithelium-derived factor reduces pulmonary vascular tone in the newborn rat.

  Journal of applied physiology (Bethesda, Md. : 1985) 20040401

• The cognition-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo.

  The Journal of pharmacology and experimental therapeutics 20040401

• Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal.

  Molecular psychiatry 20040401

• Insulin regulates protein kinase CbetaII alternative splicing in multiple target tissues: development of a hormonally responsive heterologous minigene.

  Molecular endocrinology (Baltimore, Md.) 20040401

• Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthase expression.

  Hypertension (Dallas, Tex. : 1979) 20040401

• Alterations in Ca2+-dependent and cAMP-dependent signaling pathways affect neurogenesis and melanogenesis of quail neural crest cells in vitro.

  Development genes and evolution 20040401

• Heat-shock response is associated with enhanced contractility of vascular smooth muscle in isolated rat aorta.

  Naunyn-Schmiedeberg's archives of pharmacology 20040401

• Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.

  International journal of molecular medicine 20040401

• IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells.

  International journal of molecular medicine 20040401

• Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway.

  Biochemical pharmacology 20040401

• Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranulation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line.

  Journal of immunology (Baltimore, Md. : 1950) 20040401

• PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos.

  Developmental dynamics : an official publication of the American Association of Anatomists 20040401

• Phosphoinositide 3-kinases and the regulation of platelet function.

  Biochemical Society transactions 20040401

• 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells.

  Toxicology and applied pharmacology 20040401

• Phosphatidylinositol-3 kinase is distinctively required for mu-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinase.

  Journal of neurochemistry 20040401

• Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive oxygen species in human blood neutrophils.

  Environmental health perspectives 20040401

• Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas.

  Journal of pediatric surgery 20040401

• In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathway.

  Molecular immunology 20040401

• Both mitogen activated protein kinase and the mammalian target of rapamycin modulate the development of functional renal proximal tubules in matrigel.

  Journal of cell science 20040401

• Mechanism of human urotensin II-induced contraction in rat aorta.

  Journal of pharmacological sciences 20040401

• Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells.

  Human immunology 20040401

• Akt and Ca2+ signaling in endothelial cells.

  Molecular and cellular biochemistry 20040401

• Blue light-induced chloroplast reorientations in Lemna trisulca L. (duckweed) are controlled by two separable cellular mechanisms as suggested by different sensitivity to wortmannin.

  Photochemistry and photobiology 20040401

• Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathway.

  The Journal of biological chemistry 20040319

• Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways.

  The Journal of biological chemistry 20040319

• Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting.

  The Journal of biological chemistry 20040319

• Sargaquinoic acid supports the survival of neuronal PC12D cells in a nerve growth factor-independent manner.

  European journal of pharmacology 20040319

• Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.

  Circulation 20040316

• Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat.

  Blood 20040315

• Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase(PI3-kinase) pathway.

  Biochemical pharmacology 20040315

• Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development.

  Journal of cell science 20040315

• Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.

  Life sciences 20040312

• Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.

  British journal of cancer 20040308

• Platelet factor 4 (PF-4)-induced neutrophil adhesion is controlled by src-kinases, whereas PF-4-mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase.

  Blood 20040301

• Mechanisms of shear stress-induced endothelial nitric-oxide synthase phosphorylation and expression in ovine fetoplacental artery endothelial cells.

  Biology of reproduction 20040301

• Angiotensin II regulation of the Na+ pump involves the phosphatidylinositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways in vascular smooth muscle cells.

  Endocrinology 20040301

• C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro.

  Arteriosclerosis, thrombosis, and vascular biology 20040301

• Epidermal growth factor receptor is activated by hyposmolarity and is an early signal modulating osmolyte efflux pathways in Swiss 3T3 fibroblasts.

  Pflugers Archiv : European journal of physiology 20040301

• Characterization of G proteins involved in activation of nonselective cation channels and arachidonic acid release by norepinephrine/alpha1A-adrenergic receptors.

  American journal of physiology. Cell physiology 20040301

• Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.

  Diabetologia 20040301

• Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase.

  Diabetologia 20040301

• Responses and signaling pathways in human optic nerve head astrocytes exposed to hydrostatic pressure in vitro.

  Glia 20040301

• Preconditioning-induced cytoprotection in hepatocytes requires Ca(2+)-dependent exocytosis of lysosomes.

  Journal of cell science 20040301

• The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells.

  Journal of cell science 20040301

• Identification of multivesicular bodies as prevacuolar compartments in Nicotiana tabacum BY-2 cells.

  The Plant cell 20040301

• Phosphatidylinositol 3-kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-kappa B signaling pathways are required for B cell antigen receptor-mediated cyclin D2 induction in mature B cells.

  Journal of immunology (Baltimore, Md. : 1950) 20040301

• Rapid effects of 17beta-estradiol on cell signaling and function of Mytilus hemocytes.

  General and comparative endocrinology 20040301

• Relationship between the radiosensitizing effect of wortmannin, DNA double-strand break rejoining, and p21WAF1 induction in human normal and tumor-derived cells.

  Molecular carcinogenesis 20040301

• Glycogen synthase kinase-3beta is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1.

  Circulation journal : official journal of the Japanese Circulation Society 20040301

• Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages.

  Neurobiology of disease 20040301

• Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones.

  Journal of neurochemistry 20040301

• NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.

  Journal of molecular and cellular cardiology 20040301

• Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.

  The Journal of endocrinology 20040301

• Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition.

  Molecular and cellular biochemistry 20040301

• Regulation of caspase activation in axotomized retinal ganglion cells.

  Molecular and cellular neurosciences 20040301

• Differential involvement of phosphatidylinositol 3-kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic effects on cultured striatal neurons.

  Molecular and cellular neurosciences 20040301

• Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.

  Molecular cancer research : MCR 20040301

• Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway.

  Molecular cancer research : MCR 20040301

• 3-methyladenine inhibits autophagy in tobacco culture cells under sucrose starvation conditions.

  Plant & cell physiology 20040301

• Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20040301

• Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

• Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol 3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil hippocampus.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040301

• Src kinase-dependent epidermal growth factor receptor transactivation in PPARgamma ligand-induced suppression of Porphyromonas gingivalis interference with salivary mucin synthesis.

  IUBMB life 20040301

• Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B.

  The Journal of biological chemistry 20040227

• ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.

  European journal of pharmacology 20040223

• Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.

  The Journal of biological chemistry 20040220

• WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.

  The Biochemical journal 20040215

• A mutant high-density lipoprotein receptor inhibits proliferation of human breast cancer cells.

  Cancer research 20040215

• LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism.

  FEBS letters 20040213

• Control of oncogenesis and cancer therapy resistance.

  British journal of cancer 20040209

• Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation.

  Circulation research 20040206

• Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.

  European journal of pharmacology 20040206

• Phosphatidylinositol 3-kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle.

  Endocrinology 20040201

• Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma.

  Carcinogenesis 20040201

• Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase.

  Cellular signalling 20040201

• Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium.

  Laboratory investigation; a journal of technical methods and pathology 20040201

• Adenovirus gene transfer of recombinant endothelial nitric oxide synthase enhances contractile function in ventricular myocytes.

  Journal of cardiovascular pharmacology 20040201

• Effects of prostaglandin F2alpha, latanoprost and carbachol on phosphoinositide turnover, MAP kinases, myosin light chain phosphorylation and contraction and functional existence and expression of FP receptors in bovine iris sphincter.

  Experimental eye research 20040201

• Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein.

  Molecular pharmacology 20040201

• Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis.

  Expert review of anticancer therapy 20040201

• Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging phosphatidylinositol-3 kinase and beta1-integrin signaling in vitro.

  International journal of radiation oncology, biology, physics 20040201

• Regulation of beta-amyloid precursor protein expression by brain-derived neurotrophic factor involves activation of both the Ras and phosphatidylinositide 3-kinase signalling pathways.

  Journal of neurochemistry 20040201

• Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells.

  Gastroenterology 20040201

• FSH activates phosphatidylinositol 3-kinase/protein kinase B signaling pathway in 20-day-old Sertoli cells independently of IGF-I.

  The Journal of endocrinology 20040201

• Role of DNA-dependent protein kinase in the process of radiation-induced aberration formation.

  International journal of radiation biology 20040201

• Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa.

  Journal of receptor and signal transduction research 20040201

• Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures.

  Brain research. Developmental brain research 20040131

• Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling.

  The Journal of biological chemistry 20040130

• CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.

  The Journal of biological chemistry 20040130

• Serum amyloid A-induced mRNA expression and release of tumor necrosis factor-alpha (TNF-alpha) in human neutrophils.

  Immunology letters 20040130

• SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.

  Oncogene 20040129

• Possible mechanism of polycation liposome (PCL)-mediated gene transfer.

  Biochimica et biophysica acta 20040128

• Signaling cross-talk from Gbeta4 subunit to Elk-1 in the rapid action of androgens.

  The Journal of biological chemistry 20040123

• The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway.

  The Journal of biological chemistry 20040123

• Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway.

  Circulation 20040120

• Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils.

  European journal of pharmacology 20040119

• Localization of low density lipoprotein receptor-related protein 1 to caveolae in 3T3-L1 adipocytes in response to insulin treatment.

  The Journal of biological chemistry 20040116

• Effect of vascular endothelial growth factor and epidermal growth factor on iatrogenic apoptosis in human endothelial cells.

  Biochemical pharmacology 20040115

• Retinoic acid-induced neuritogenesis of human neuroblastoma SH-SY5Y cells is ERK independent and PKC dependent.

  Journal of neuroscience research 20040115

• Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via phosphatidylinositol 3-kinase signaling pathway.

  World journal of gastroenterology 20040115

• Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death.

  European journal of pharmacology 20040112

• Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites.

  The Journal of biological chemistry 20040102

• Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42.

  FEBS letters 20040102

• Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.

  American journal of physiology. Lung cellular and molecular physiology 20040101

• Autocrine regulation of glucose metabolism in pancreatic islets.

  American journal of physiology. Endocrinology and metabolism 20040101

• Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of phosphatidylinositol 3-kinase.

  Molecular endocrinology (Baltimore, Md.) 20040101

• Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases.

  The Journal of pharmacology and experimental therapeutics 20040101

• TOR action in mammalian cells and in Caenorhabditis elegans.

  Current topics in microbiology and immunology 20040101

• Radiosensitizer effect of wortmannin in radioresistant bladder tumoral cell lines.

  International journal of oncology 20040101

• Inhibition of phosphatidylinositol 3-kinase causes apoptosis in retinoic acid differentiated hl-60 leukemia cells.

  Cell cycle (Georgetown, Tex.) 20040101

• Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways.

  Nature biotechnology 20040101

• Akt2: a role in breast cancer metastasis.

  Breast cancer research : BCR 20040101

• Menstrual effluent induces epithelial-mesenchymal transitions in mesothelial cells.

  Human reproduction (Oxford, England) 20040101

• Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis.

  Journal of immunology (Baltimore, Md. : 1950) 20040101

• Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins.

  Journal of neurochemistry 20040101

• Platelet-activating factor increases pH(i) in bovine neutrophils through the PI3K-ERK1/2 pathway.

  British journal of pharmacology 20040101

• Interleukin 7 induces the growth of breast cancer cells through a wortmannin-sensitive pathway.

  The British journal of surgery 20040101

• Activation of integrin alpha IIb beta 3 in the glycoprotein Ib-high population of a megakaryocytic cell line, CMK, by inside-out signaling.

  Journal of thrombosis and haemostasis : JTH 20040101

• Opposing effects of PI3 kinase pathway activation on human myeloid and erythroid progenitor cell proliferation and differentiation in vitro.

  Experimental hematology 20040101

• Augmented 18F-FDG uptake in activated monocytes occurs during the priming process and involves tyrosine kinases and protein kinase C.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040101

• Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways.

  Neuroscience 20040101

• Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activity.

  International journal of radiation biology 20040101

• Desensitization of muscarinic receptors.

  Receptors & channels 20040101

• Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt.

  Archives of pharmacal research 20040101

• Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells.

  Molecular and cellular biochemistry 20040101

• Vanadate activated Akt and promoted S phase entry.

  Molecular and cellular biochemistry 20040101

• C5a delays apoptosis of human neutrophils via an extracellular signal-regulated kinase and Bad-mediated signalling pathway.

  European journal of clinical investigation 20040101

• Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis.

  IUBMB life 20040101

• Poly (ADP-ribose) polymerase and DNA-dependent protein kinase: differential activation in vivo.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20040101

• Neurotrophin effects on neuroblastoma cells: correlation with trk and p75NTR expression and influence of Trk receptor bodies.

  Journal of neuro-oncology 20040101

• Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway.

  Molecular cancer 20040101

• IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways.

  Arthritis research & therapy 20040101

• Translation of the radioresistance kinase TLK1B is induced by gamma-irradiation through activation of mTOR and phosphorylation of 4E-BP1.

  BMC molecular biology 20040101

• Involvement of protein kinases on the process of erythrophagocytis by Entamoeba histolytica.

  Cell biology international 20040101

• Signal transduction pathway in endothelial dysfunction.

  Surgical infections 20040101

• PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors.

  BMC biology 20040101

• Mechanisms of DNA double strand break repair and chromosome aberration formation.

  Cytogenetic and genome research 20040101

• Serratia marcescens internalization and replication in human bladder epithelial cells.

  BMC infectious diseases 20040101

• The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity.

  BMC cell biology 20040101

• Intracellular phenotype of Mycobacterium avium enters macrophages primarily by a macropinocytosis-like mechanism and survives in a compartment that differs from that with extracellular phenotype.

  Cell biology international 20040101

• Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences.

  Journal of andrology 20040101

• The uses of genome-wide yeast mutant collections.

  Genome biology 20040101

• Role of epidermal growth factor receptor transactivation in PPAR gamma-dependent suppression of Helicobacter pylori interference with gastric mucin synthesis.

  Inflammopharmacology 20040101

• The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.

  DNA repair 20040101

• The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1.

  BMC pharmacology 20040101

• Stobadine-modulated human neutrophil functional responsiveness: effect on particular and soluble stimulation.

  Methods and findings in experimental and clinical pharmacology 20040101

• Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C.

  Acta biochimica Polonica 20040101

• Lithium-mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase-dependent activation of protein kinase C-alpha.

  Journal of molecular neuroscience : MN 20040101

• The role of PTEN in allergic inflammation.

  Archivum immunologiae et therapiae experimentalis 20040101

• Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to beta-adrenergic G-protein-coupled receptor activation.

  Inflammopharmacology 20040101

• Rapid actions of estradiol on cyclic amp response-element binding protein phosphorylation in dorsal root ganglion neurons.

  Neuroscience 20040101

• Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells.

  Molecular cancer 20040101

• In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316.

  Oncology research 20040101

• Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.

  BMC neuroscience 20040101

• The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide.

  BMC cell biology 20040101

• Effects of KST48 [(2R,5SR)3-(2-chlorobenzoyl)-5-(4-chlorophenoxymethyl)-2(3,4-dichlorophenyl) oxazolidine] on glucose transport in L6 myocytes.

  Arzneimittel-Forschung 20040101

• KGF-induced motility of breast cancer cells is dependent on Grb2 and Erk1,2.

  Clinical & experimental metastasis 20040101

• [alpha-Actinin-4 and p65/RelA subunit of NF-kappaB transcription factor are co-localized and migrate together into the nucleus in EGF-stimulated A431 cell].

  Tsitologiia 20040101

• [Role of phosphatidylinositol 3-kinase in platelet aggregation in type 1 diabetes mellitus].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20040101

• Involvement of fas/fas ligand in ultraviolet B-induced apoptosis of murine peritoneal macrophages.

  Toxicology mechanisms and methods 20040101

• UV-B Induced stimulation of phosphatidylinositol 3-kinase in human fetal hepatocytes.

  Indian journal of clinical biochemistry : IJCB 20040101

• Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

  The Journal of biological chemistry 20031226

• Leptin suppresses Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis.

  Biochemical and biophysical research communications 20031226

• PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive phosphatidylinositol 3-kinase.

  FEBS letters 20031218

• ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1.

  Blood 20031215

• Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.

  The Biochemical journal 20031215

• Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor.

  The Biochemical journal 20031215

• Potentiation of quantal secretion by insulin-like growth factor-1 at developing motoneurons in Xenopus cell culture.

  The Journal of physiology 20031215

• Long vasodilator reflexes projecting through the myenteric plexus in guinea-pig ileum.

  The Journal of physiology 20031215

• Involvement of MAP kinase signal transduction pathway in UVB-induced activation of macrophages in vitro.

  Immunology letters 20031215

• Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation.

  Cancer research 20031215

• p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning.

  FEBS letters 20031204

• Effects of kinase inhibitors on TGF-beta induced upregulation of Kv1.3 K+ channels in brain macrophages.

  Pflugers Archiv : European journal of physiology 20031201

• Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells.

  Oral oncology 20031201

• Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents.

  Journal of cancer research and clinical oncology 20031201

• IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.

  Cellular signalling 20031201

• Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.

  Cellular signalling 20031201

• Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation.

  Cellular signalling 20031201

• Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide.

  Antioxidants & redox signaling 20031201

• Impact of a novel cardioprotective agent on the ischaemia-reperfusion-induced Akt kinase activation.

  Biochemical pharmacology 20031201

• Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons.

  Journal of neurochemistry 20031201

• Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media.

  Analytical biochemistry 20031201

• DEC-205lo Langerinlo neonatal Langerhans' cells preferentially utilize a wortmannin-sensitive, fluid-phase pathway to internalize exogenous antigen.

  Immunology 20031201

• Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.

  International immunopharmacology 20031201

• Signaling pathways used in trabecular matrix metalloproteinase response to mechanical stretch.

  Investigative ophthalmology & visual science 20031201

• Isoflurane enhances the expression and activity of glutamate transporter type 3 in C6 glioma cells.

  Anesthesiology 20031201

• Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status.

  Cellular microbiology 20031201

• Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.

  International immunology 20031201

• Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt.

  Journal of molecular and cellular cardiology 20031201

• Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.

  Journal of neurochemistry 20031201

• Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation.

  Journal of neurochemistry 20031201

• Enhancement of ischemia-induced tyrosine phosphorylation of Kv1.2 by vascular endothelial growth factor via activation of phosphatidylinositol 3-kinase.

  Journal of neurochemistry 20031201

• [Cell biological mechanism involved in the effect of sodium selenite on improving insulin sensitivity].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20031201

• Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of phosphatidylinositol 3-kinase pathway in biomembrane synthesis and restitution of apical epithelial membrane.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20031201

• Radiosensitization of normal human cells by LY294002: cell killing and the rejoining of DNA and interphase chromosome breaks.

  Journal of radiation research 20031201

• The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase.

  The Journal of biological chemistry 20031128

• Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation.

  European journal of pharmacology 20031128

• [EGF/PI3K signaling pathway regulates the expression of osteopontin in liver cancer HepG2 cells].

  Zhonghua yi xue za zhi 20031125

• Mitigation of tumor necrosis factor alpha cytotoxicity by aurintricarboxylic acid in human peripheral B lymphocytes.

  Biochemical pharmacology 20031115

• Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes.

  The Journal of biological chemistry 20031114

• Adiponectin stimulates production of nitric oxide in vascular endothelial cells.

  The Journal of biological chemistry 20031107

• Akt signaling in skeletal muscle: regulation by exercise and passive stretch.

  American journal of physiology. Endocrinology and metabolism 20031101

• PI3-kinase inhibitors abolish the enhanced chronotropic effects of angiotensin II in spontaneously hypertensive rat brain neurons.

  Journal of neurophysiology 20031101

• TRAIL/Apo2L ligands induce apoptosis in malignant rhabdoid tumor cell lines.

  Pediatric research 20031101

• The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression.

  Leukemia 20031101

• Insulin promotes formation of polymerized microtubules by a phosphatidylinositol 3-kinase-independent, actin-dependent pathway in 3T3-L1 adipocytes.

  Endocrinology 20031101

• Stent implantation activates Akt in the vessel wall: role of mechanical stretch in vascular smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20031101

• Cross talk between P2Y2 nucleotide receptors and CXC chemokine receptor 2 resulting in enhanced Ca2+ signaling involves enhancement of phospholipase C activity and is enabled by incremental Ca2+ release in human embryonic kidney cells.

  The Journal of pharmacology and experimental therapeutics 20031101

• RANKL regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031101

• Potentiation of the osmosensitive taurine release and cell volume regulation by cytosolic Ca2+ rise in cultured cerebellar astrocytes.

  Glia 20031101

• PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.

  Nature neuroscience 20031101

• Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery.

  British journal of pharmacology 20031101

• Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist.

  International immunopharmacology 20031101

• Inhibition of Drynariae Rhizoma extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts.

  International immunopharmacology 20031101

• Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 Via NF-kappaB induced by oxidative stress.

  Hypertension (Dallas, Tex. : 1979) 20031101

• Involvement of 3Na+/2K+ ATP-ase and Pi-3 kinase in the response of skeletal muscle ATP-sensitive K+ channels to insulin.

  Neuromuscular disorders : NMD 20031101

• Distinct LPS-induced signals regulate LPS uptake and morphological changes in medfly hemocytes.

  Insect biochemistry and molecular biology 20031101

• Akt activation induced by an antioxidant compound during ischemia-reperfusion.

  Free radical biology & medicine 20031101

• Bacterial DNA activates human neutrophils by a CpG-independent pathway.

  European journal of immunology 20031101

• AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets.

  Thrombosis and haemostasis 20031101

• Regulation of vascular endothelial growth factor expression by insulin-like growth factor I in thyroid carcinomas.

  The Journal of clinical endocrinology and metabolism 20031101

• Contrasting effects of nateglinide and rosiglitazone on insulin secretion and phospholipase C activation.

  Metabolism: clinical and experimental 20031101

• [Signal transduction and development of drug for brain ischemic insult].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20031101

• [New target for the inhibitors of gastric acid secretion. Inhibition of myosin and actin activities via the apical membrane of parietal cells in dogs].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20031101

• Direct and biochemical interaction between dopamine D3 receptor and elongation factor-1Bbetagamma.

  Life sciences 20031024

• Negative regulatory role of PI3-kinase in TNF-induced tumor necrosis.

  International journal of cancer 20031020

• Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity.

  The Journal of biological chemistry 20031017

• Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent.

  Experimental cell research 20031015

• Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase.

  Experimental cell research 20031015

• The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.

  Experimental cell research 20031015

• Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway.

  Cancer research 20031015

• Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface.

  The Journal of biological chemistry 20031010

• Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1.

  The Journal of biological chemistry 20031003

• Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway.

  The Journal of biological chemistry 20031003

• Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages.

  The Journal of biological chemistry 20031003

• Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.

  The Journal of biological chemistry 20031003

• Protection of internal (TTAGGG)n repeats in Chinese hamster cells by telomeric protein TRF1.

  Oncogene 20031002

• A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes.

  Blood 20031001

• Neuronal necrosis inhibition by insulin through protein kinase C activation.

  The Journal of pharmacology and experimental therapeutics 20031001

• Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway.

  American journal of physiology. Gastrointestinal and liver physiology 20031001

• Wortmannin alters the intracellular trafficking of the bradykinin B2 receptor: role of phosphoinositide 3-kinase and Rab5.

  The Biochemical journal 20031001

• Fibroblast growth factors regulate prolactin transcription via an atypical Rac-dependent signaling pathway.

  Molecular endocrinology (Baltimore, Md.) 20031001

• Involvement of signaling through protein kinase C and phosphatidylinositol 3-kinase in the excystation and metacystic development of Entamoeba invadens.

  Parasitology research 20031001

• PKC-zeta is required for angiotensin II-induced activation of ERK and synthesis of C-FOS in MCF-7 cells.

  Journal of cellular physiology 20031001

• Lysophosphatidic acid regulates the proliferation and migration of olfactory ensheathing cells in vitro.

  Glia 20031001

• Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.

  Endocrinology 20031001

• Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway.

  Radiation research 20031001

• Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.

  Kidney international 20031001

• Insulin and glucagon signaling in regulation of microsomal epoxide hydrolase expression in primary cultured rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20031001

• Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20031001

• Role of the small GTPase Rho in modulation of the inwardly rectifying potassium channel Kir2.1.

  Molecular pharmacology 20031001

• Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK.

  British journal of pharmacology 20031001

• Differential activation of phosphatidylinositol 3-kinase signaling during proliferation and differentiation of lens epithelial cells.

  Investigative ophthalmology & visual science 20031001

• Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.

  European journal of biochemistry 20031001

• Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation.

  Diabetes 20031001

• Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways.

  Diabetes 20031001

• Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells.

  Journal of the American Society of Nephrology : JASN 20031001

• Assessment of the roles of mitogen-activated protein kinase and phosphatidyl inositol 3-kinase/protein kinase B pathways in the basic fibroblast growth factor regulation of Sertoli cell function.

  Journal of molecular endocrinology 20031001

• Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.

  Journal of thrombosis and haemostasis : JTH 20031001

• Negative regulation of interleukin-12 production by a rapamycin-sensitive signaling pathway: a brief communication.

  Experimental biology and medicine (Maywood, N.J.) 20031001

• pH-dependent translocation of alpha-tocopherol transfer protein (alpha-TTP) between hepatic cytosol and late endosomes.

  Genes to cells : devoted to molecular & cellular mechanisms 20031001

• A simple technique for reducing edge effect in cell-based assays.

  Journal of biomolecular screening 20031001

• Interactive competition between homologous recombination and non-homologous end joining.

  Molecular cancer research : MCR 20031001

• Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase.

  Alcoholism, clinical and experimental research 20031001

• Chromatin- and temperature-dependent modulation of radiation-induced double-strand breaks.

  International journal of radiation biology 20031001

• Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice.

  Liver international : official journal of the International Association for the Study of the Liver 20031001

• Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.

  European journal of pharmacology 20030930

• Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin.

  The Journal of biological chemistry 20030926

• Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness.

  Biochemical and biophysical research communications 20030919

• Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.

  Oncogene 20030918

• Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways.

  Respiratory physiology & neurobiology 20030916

• Novel pathways of F-actin polymerization in the human neutrophil.

  Blood 20030915

• Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways.

  Journal of neuroscience research 20030915

• Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes.

  Regulatory peptides 20030915

• Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.

  Cancer research 20030915

• Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.

  Oncogene 20030911

• Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin.

  The Journal of biological chemistry 20030905

• Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.

  The Journal of biological chemistry 20030905

• 2'-benzyloxychalcone derivatives stimulate glucose uptake in 3T3-L1 adipocytes.

  Life sciences 20030905

• Selective role of PI3K delta in neutrophil inflammatory responses.

  Biochemical and biophysical research communications 20030905

• Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.

  Oncogene 20030904

• DNA damage foci at dysfunctional telomeres.

  Current biology : CB 20030902

• Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT/PKB.

  American journal of physiology. Heart and circulatory physiology 20030901

• OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells.

  Journal of lipid research 20030901

• Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor.

  The Journal of physiology 20030901

• Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

  The Biochemical journal 20030901

• Eicosapentaenoic acid protects endothelial cells against anoikis through restoration of cFLIP.

  Hypertension (Dallas, Tex. : 1979) 20030901

• Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation.

  Journal of cell science 20030901

• Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1.

  International journal of oncology 20030901

• Effects of nonselective cation channels and PI3K on endothelin-1-induced PYK2 tyrosine phosphorylation in C6 glioma cells.

  American journal of physiology. Cell physiology 20030901

• Angiotensin II stimulates NHE3 activity by exocytic insertion of the transporter: role of PI 3-kinase.

  Kidney international 20030901

• Characterization of Ca2+ channels and G proteins involved in arachidonic acid release by endothelin-1/endothelinA receptor.

  Molecular pharmacology 20030901

• Participation of growth factor signal transduction pathways in estradiol facilitation of female reproductive behavior.

  Endocrinology 20030901

• Protein kinase B is obligatory for follicle-stimulating hormone-induced granulosa cell differentiation.

  Endocrinology 20030901

• Phospholipase C and phosphatidylinositol 3-kinase signaling are involved in the exogenous arachidonic acid-stimulated respiratory burst in human neutrophils.

  Journal of leukocyte biology 20030901

• Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase.

  European journal of biochemistry 20030901

• Insulin addition after ischemia improves recovery of function equal to ischemic preconditioning in rat heart.

  Basic research in cardiology 20030901

• Diethylsulphate and methylnitrosourea affect different targets in Chinese hamster fibroblasts: possible mechanisms of aneuploidy induction by these agents.

  Mutagenesis 20030901

• Second window of protection following myocardial preconditioning: an essential role for PI3 kinase and p70S6 kinase.

  Journal of molecular and cellular cardiology 20030901

• [The biological effect of the phosphatidylinositol 3-kinase wortmannin following thermal neutron irradiation].

  Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 20030901

• Diversity of signaling underlying responses mediated by selective activation of the platelet thromboxane A2 (TXA2) receptor; pharmacological and kinetic studies in vitro.

  Platelets 20030901

• Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells.

  The Journal of biological chemistry 20030829

• Betacellulin and amphiregulin induce upregulation of cyclin D1 and DNA synthesis activity through differential signaling pathways in vascular smooth muscle cells.

  Circulation research 20030822

• Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor.

  Blood 20030815

• Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase.

  Blood 20030815

• Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.

  The Biochemical journal 20030815

• Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca(2+)- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells.

  The Biochemical journal 20030815

• Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calcium.

  The Journal of biological chemistry 20030815

• Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway.

  The Journal of biological chemistry 20030815

• PI3K inhibitors changed the p53-induced response of Saos-2 cells from growth arrest to apoptosis.

  Biochemical and biophysical research communications 20030815

• Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.

  The EMBO journal 20030815

• S-phase delay in human hepatocellular carcinoma cells induced by overexpression of integrin beta1.

  World journal of gastroenterology 20030815

• Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.

  The Journal of clinical investigation 20030815

• Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).

  The Journal of biological chemistry 20030808

• Wortmannin enhances lipopolysaccharide-induced inducible nitric oxide synthase expression in microglia in the presence of astrocytes in rats.

  Neuroscience letters 20030807

• Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts.

  Oncogene 20030807

• Mechanosensitive p27Kip1 regulation and cell cycle entry in vascular smooth muscle cells.

  Circulation 20030805

• Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.

  American journal of physiology. Gastrointestinal and liver physiology 20030801

• Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles.

  American journal of physiology. Gastrointestinal and liver physiology 20030801

• Expression and molecular pharmacology of the mouse CRTH2 receptor.

  The Journal of pharmacology and experimental therapeutics 20030801

• Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool.

  The Journal of biological chemistry 20030801

• Intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent pathways.

  The Journal of biological chemistry 20030801

• Osteopontin stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells.

  The Journal of biological chemistry 20030801

• Retinoic acid signaling through PI 3-kinase induces differentiation of human endometrial adenocarcinoma cells.

  Experimental and molecular pathology 20030801

• Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK.

  International journal of oncology 20030801

• Protective effects of thrombopoietin and stem cell factor on X-irradiated CD34+ megakaryocytic progenitor cells from human placental and umbilical cord blood.

  Radiation research 20030801

• IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.

  Cell death and differentiation 20030801

• Distinct signaling pathways regulate differential opioid effects on actin cytoskeleton in malignant MCF7 and nonmalignant MCF12A human breast epithelial cells.

  Experimental cell research 20030801

• A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined.

  Diabetes 20030801

• MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.

  Molecular therapy : the journal of the American Society of Gene Therapy 20030801

• Phosphatidylinositol 3'-kinase is required for growth of mast cells expressing the kit catalytic domain mutant.

  Cancer research 20030801

• Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer.

  Surgery 20030801

• Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric-oxide synthase activation and cytotoxicity.

  The Journal of biological chemistry 20030725

• ERK 1/2- and JNKs-dependent synthesis of interleukins 6 and 8 by fibroblast-like synoviocytes stimulated with protein I/II, a modulin from oral streptococci, requires focal adhesion kinase.

  The Journal of biological chemistry 20030725

• Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression.

  Circulation research 20030725

• Lysophosphatidic acid induces alpha1B-adrenergic receptor phosphorylation through G beta gamma, phosphoinositide 3-kinase, protein kinase C and epidermal growth factor receptor transactivation.

  Biochimica et biophysica acta 20030721

• C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons.

  The Biochemical journal 20030715

• Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.

  The Biochemical journal 20030715

• Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.

  The Biochemical journal 20030715

• Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide.

  Journal of immunology (Baltimore, Md. : 1950) 20030715

• Involvement of the extracellular signal regulated kinase pathway in hydrocarbon-induced reactive oxygen species formation in human neutrophil granulocytes.

  Toxicology and applied pharmacology 20030715

• Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor.

  The Journal of biological chemistry 20030711

• Phosphatidic acid production, required for cholecystokinin octapeptide-stimulated amylase secretion from pancreatic acinar AR42J cells, is regulated by a wortmannin-sensitive process.

  Biochemical and biophysical research communications 20030711

• Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity.

  Journal of neurochemistry 20030701

• Cytoplasmic bacteria can be targets for autophagy.

  Cellular microbiology 20030701

• The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells.

  Biochemical pharmacology 20030701

• EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway.

  Journal of molecular and cellular cardiology 20030701

• Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling.

  Diabetes 20030701

• Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes.

  British journal of pharmacology 20030701

• Pharmacological profile of store-operated channels in cerebral arteriolar smooth muscle cells.

  British journal of pharmacology 20030701

• Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells.

  Cancer research 20030701

• Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways.

  Cancer research 20030701

• Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells.

  The Journal of clinical endocrinology and metabolism 20030701

• Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin.

  European journal of biochemistry 20030701

• The release of basogranulin in response to IgE-dependent and IgE-independent stimuli: validity of basogranulin measurement as an indicator of basophil activation.

  The Journal of allergy and clinical immunology 20030701

• Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma.

  Laboratory investigation; a journal of technical methods and pathology 20030701

• Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation.

  The Journal of surgical research 20030701

• Protein kinase B in the diabetic heart.

  Molecular and cellular biochemistry 20030701

• Evidence that nitroprusside stimulates glucose uptake in isolated rat cardiomyocytes via mitogen-activated protein kinase.

  Archives of physiology and biochemistry 20030701

• Cell signalling of the GLP-1 action in rat liver.

  Molecular and cellular endocrinology 20030630

• Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.

  International journal of cancer 20030620

• Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis.

  Circulation 20030617

• Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes.

  The Biochemical journal 20030615

• Characterization of maleimide-activated Ca2+ entry in neutrophils.

  Biochemical pharmacology 20030615

• Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615

• Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.

  The Journal of biological chemistry 20030613

• Reconstitution of phosphoinositide 3-kinase-dependent insulin signaling in a cell-free system.

  The Journal of biological chemistry 20030613

• P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.

  Biochemical and biophysical research communications 20030613

• Stimulation of glucose uptake by chronic vanadate pretreatment in cardiomyocytes requires PI 3-kinase and p38 MAPK activation.

  American journal of physiology. Endocrinology and metabolism 20030601

• Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3',5'-monophosphate by relaxin.

  Molecular endocrinology (Baltimore, Md.) 20030601

• Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes.

  American journal of physiology. Renal physiology 20030601

• Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway.

  Arteriosclerosis, thrombosis, and vascular biology 20030601

• IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells.

  Cellular signalling 20030601

• Mechanical constraint imposed on plasma membrane through transverse phospholipid imbalance induces reversible actin polymerization via phosphoinositide 3-kinase activation.

  Journal of cell science 20030601

• Decreases in ANP secretion by lysophosphatidylcholine through protein kinase C.

  Hypertension (Dallas, Tex. : 1979) 20030601

• Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels.

  Neuropharmacology 20030601

• Experimental researches on the role of phosphoinositide-specific phospholipase C in 4-hydroxynonenal induced exocytosis.

  Cell biochemistry and function 20030601

• Sphingosine 1-phosphate and control of vascular tone.

  American journal of physiology. Heart and circulatory physiology 20030601

• The same cellular signaling pathways mediate survival in sensory neurons that switch their trophic requirements during development.

  Journal of neurochemistry 20030601

• Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide.

  The American journal of pathology 20030601

• C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts.

  American journal of respiratory cell and molecular biology 20030601

• The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.

  Journal of the American Society of Nephrology : JASN 20030601

• Oscillatory shear stress increases smooth muscle cell proliferation and Akt phosphorylation.

  Journal of vascular surgery 20030601

• Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030601

• Histone deacetylase inhibitors activate p21(WAF1) expression via ATM.

  Cancer research 20030601

• Insulin-like growth factor-I enhances transforming growth factor-beta-induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts.

  The Journal of investigative dermatology 20030601

• A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway.

  British journal of pharmacology 20030601

• Epidermal growth factor up-regulates expression of transforming growth factor beta receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibroblasts.

  Arthritis and rheumatism 20030601

• A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus.

  British journal of pharmacology 20030601

• Effects of prostaglandin F2alpha and latanoprost on phosphoinositide turnover, myosin light chain phosphorylation and contraction in cat iris sphincter.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030601

• Insulin stimulates expression of the pyruvate kinase M gene in 3T3-L1 adipocytes.

  Bioscience, biotechnology, and biochemistry 20030601

• Identification of genes related to invasion and metastasis in pancreatic cancer by cDNA representational difference analysis.

  Journal of experimental & clinical cancer research : CR 20030601

• Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.

  Molecular and cellular biochemistry 20030601

• Regulation of leptin on insulin secretion and sulfonulurea receptor 1 transcription level in isolated rats pancreatic islets.

  Chinese medical journal 20030601

• Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1.

  Nitric oxide : biology and chemistry 20030601

• DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway.

  Journal of radiation research 20030601

• Interactions of insulin-like growth factors and estradiol in rat pituitary gonadotrophs.

  Growth factors (Chur, Switzerland) 20030601

• Vasopressin mediates neuroprotection in mice by stimulation of V1 vasopressin receptors: influence of PI-3 kinase and gap junction inhibitors.

  Indian journal of experimental biology 20030601

• Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

  The Journal of biological chemistry 20030530

• Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v-src oncogene.

  FEBS letters 20030522

• Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons.

  Neuron 20030522

• Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.

  International journal of cancer 20030520

• Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets.

  The Journal of biological chemistry 20030516

• Serine 338 phosphorylation is dispensable for activation of c-Raf1.

  The Journal of biological chemistry 20030516

• CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.

  The Journal of biological chemistry 20030516

• Vitamin D-dependent recruitment of DNA-PK to the chromatinized negative vitamin D response element in the PTHrP gene is required for gene repression by vitamin D.

  Biochemical and biophysical research communications 20030516

• Insulin-like growth factor I-stimulated melanoma cell migration requires phosphoinositide 3-kinase but not extracellular-regulated kinase activation.

  Experimental cell research 20030515

• Insulin induces expression of adenosine kinase gene in rat lymphocytes by signaling through the mitogen-activated protein kinase pathway.

  Experimental cell research 20030515

• Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils.

  Journal of immunology (Baltimore, Md. : 1950) 20030515

• Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.

  The EMBO journal 20030515

• Redox stress regulates cell proliferation and apoptosis of human hepatoma through Akt protein phosphorylation.

  FEBS letters 20030508

• Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro.

  British journal of cancer 20030506

• Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase.

  Blood 20030501

• Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.

  Blood 20030501

• Stimulation of glycogen synthesis by heat shock in L6 skeletal-muscle cells: regulatory role of site-specific phosphorylation of glycogen-associated protein phosphatase 1.

  The Biochemical journal 20030501

• Estradiol rapidly activates Akt via the ErbB2 signaling pathway.

  Molecular endocrinology (Baltimore, Md.) 20030501

• A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors.

  Molecular endocrinology (Baltimore, Md.) 20030501

• TNFalpha-induced apoptosis and integrin switching in human extravillous trophoblast cell line.

  Biology of reproduction 20030501

• Induction of cyclooxygenase-2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-kappaB pathways.

  Cellular signalling 20030501

• Survival pathways regulating the apoptosis induced by tumour necrosis factor-alpha in primary cultured bovine endothelial cells.

  Cellular signalling 20030501

• Activation of P2Y2 receptor induces c-FOS protein through a pathway involving mitogen-activated protein kinases and phosphoinositide 3-kinases in HeLa cells.

  Journal of cellular physiology 20030501

• Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells.

  Journal of cellular physiology 20030501

• LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway.

  American journal of physiology. Gastrointestinal and liver physiology 20030501

• Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats.

  American journal of physiology. Gastrointestinal and liver physiology 20030501

• Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase.

  Journal of neuroscience research 20030501

• Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts.

  Genes to cells : devoted to molecular & cellular mechanisms 20030501

• Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer.

  Endocrinology 20030501

• Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway.

  Thrombosis and haemostasis 20030501

• The GTPase ARF1p controls the sequence-specific vacuolar sorting route to the lytic vacuole.

  The Plant cell 20030501

• Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.

  Cell death and differentiation 20030501

• Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501

• A role for phosphatidylinositol 3-phosphate in abscisic acid-induced reactive oxygen species generation in guard cells.

  Plant physiology 20030501

• Insulin improves postischemic recovery of function through PI3K in isolated working rat heart.

  Molecular and cellular biochemistry 20030501

• Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030501

• Rapid uptake of oxidized ascorbate induces loss of cellular glutathione and oxidative stress in liver slices.

  Experimental & molecular medicine 20030430

• Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes.

  The Journal of biological chemistry 20030418

• Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin.

  The Journal of biological chemistry 20030418

• Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae.

  The Journal of biological chemistry 20030418

• The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.

  The Journal of biological chemistry 20030418

• Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1).

  The Journal of biological chemistry 20030418

• Inhibition of rat fat cell lipolysis by monoamine oxidase and semicarbazide-sensitive amine oxidase substrates.

  European journal of pharmacology 20030418

• BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells.

  Oncogene 20030417

• Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase.

  The Biochemical journal 20030415

• Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor.

  Journal of neuroscience research 20030415

• The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

  Cancer research 20030415

• Insulin-like growth factor-1 protects human dopaminergic SH-SY5Y cells from salsolinol-induced toxicity.

  Neuroscience letters 20030410

• Kinase inhibitors: not just for kinases anymore.

  Journal of medicinal chemistry 20030410

• Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells.

  FEBS letters 20030410

• Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases.

  The Journal of biological chemistry 20030404

• Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells.

  Life sciences 20030404

• Physiological concentration of atrial natriuretic peptide induces endothelial regeneration in vitro.

  American journal of physiology. Heart and circulatory physiology 20030401

• The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

• IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism.

  Kidney international 20030401

• Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity.

  Molecular and cellular biology 20030401

• Involvements of voltage-independent Ca2+ channels and phosphoinositide 3-kinase in endothelin-1-induced PYK2 tyrosine phosphorylation.

  Molecular pharmacology 20030401

• 1alpha,25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expression in human keratinocytes.

  The Journal of investigative dermatology 20030401

• Lack of interferon beta-induced radiosensitization in four out of five human glioblastoma cell lines.

  International journal of radiation oncology, biology, physics 20030401

• Tumor necrosis factor alpha (TNF-alpha)-induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase: roles of TNF-alpha in alcoholic liver diseases.

  Journal of hepatology 20030401

• In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

• Inhibition of contractile activation reduces reoxygenation-induced endothelial gap formation.

  Cardiovascular research 20030401

• Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.

  Cancer research 20030401

• Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.

  The Journal of clinical investigation 20030401

• Phosphorylation of p53 protein in A549 human pulmonary epithelial cells exposed to asbestos fibers.

  Environmental health perspectives 20030401

• Interactive effects of insulin-like growth factor-1 and beta-estradiol on endothelial nitric oxide synthase activity in rat aortic endothelial cells.

  Metabolism: clinical and experimental 20030401

• Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via phosphatidylinositol 3-kinase- and hydrogen peroxide-dependent mechanisms.

  The Journal of biological chemistry 20030328

• PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.

  Neuron 20030327

• Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathway.

  British journal of cancer 20030324

• Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit.

  The Journal of biological chemistry 20030321

• Rapamycin inhibits proliferation of human neuroblastoma cells without suppression of MycN.

  International journal of cancer 20030320

• Comparison between the effects of the rapid recombinant insulin analog Lispro (Lys B28, Pro B29) and those of human regular insulin on platelet cyclic nucleotides and aggregation.

  Thrombosis research 20030315

• Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways.

  The Journal of biological chemistry 20030314

• ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.

  The Journal of biological chemistry 20030314

• Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells.

  British journal of cancer 20030310

• Insulin modulates PC-1 processing and recruitment in cultured human cells.

  American journal of physiology. Endocrinology and metabolism 20030301

• The c-Fes protein-tyrosine kinase accelerates NGF-induced differentiation of PC12 cells through a PI3K-dependent mechanism.

  Cellular signalling 20030301

• Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways.

  Journal of cell science 20030301

• Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes.

  Journal of cellular biochemistry 20030301

• Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells.

  Endocrinology 20030301

• HIV-1 Tat-mediated apoptosis in human brain microvascular endothelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20030301

• Corticotropin-releasing factor (CRF) rapidly suppresses apoptosis by acting upstream of the activation of caspases.

  Journal of neurochemistry 20030301

• Purinergic P2Y12 receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation.

  Molecular pharmacology 20030301

• Involvement of PI3'-K, mitogen-activated protein kinase and protein kinase B in the up-regulation of the expression of nNOSalpha and nNOSbeta splicing variants induced by PRL-receptor activation in GH3 cells.

  Journal of neurochemistry 20030301

• Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation.

  Free radical biology & medicine 20030301

• Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping.

  Cancer research 20030301

• Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages.

  European journal of immunology 20030301

• Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis.

  Developmental biology 20030301

• Wortmannin enhances the induction of micronuclei by low and high LET radiation.

  Mutagenesis 20030301

• Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.

  Genes to cells : devoted to molecular & cellular mechanisms 20030301

• Intracellular mechanisms involved in leptin regulation of sympathetic outflow.

  Hypertension (Dallas, Tex. : 1979) 20030301

• Role of EGFR transactivation in angiotensin II signaling to extracellular regulated kinase in preglomerular smooth muscle cells.

  Hypertension (Dallas, Tex. : 1979) 20030301

• An endogenous peptide is involved in internal control of metamorphosis in the marine invertebrate Cassiopea xamachana (Cnidaria: Scyphozoa).

  Development genes and evolution 20030301

• Inhibition by pentoxifylline of TNF-alpha-stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-kappa B down-regulation.

  British journal of pharmacology 20030301

• Activation of peroxisome proliferator-activated receptor gamma impedes Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis through phosphatidylinositol 3-kinase/erk pathway.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030301

• Fluoride-induced apoptosis in human epithelial lung cells (A549 cells): role of different G protein-linked signal systems.

  Human & experimental toxicology 20030301

• [Anti-apoptotic effect of insulin in myocardial ischemia-reperfusion and its principal signaling pathway].

  Zhonghua nei ke za zhi 20030301

• Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite.

  The Journal of biological chemistry 20030227

• Activation of the MAP kinase cascade by exogenous calcium-sensing receptor.

  Molecular and cellular endocrinology 20030227

• Arginine vasopressin inhibition of cyclin D1 gene expression blocks the cell cycle and cell proliferation in the mouse Y1 adrenocortical tumor cell line.

  Biochemistry 20030225

• Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells.

  The Journal of biological chemistry 20030221

• Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5.

  Biochemical and biophysical research communications 20030221

• Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.

  Oncogene 20030220

• Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin.

  Circulation 20030218

• Low-energy laser irradiation enhances de novo protein synthesis via its effects on translation-regulatory proteins in skeletal muscle myoblasts.

  Biochimica et biophysica acta 20030217

• Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin.

  Blood 20030215

• Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo.

  The Journal of clinical investigation 20030215

• Na+,K+-ATPase trafficking in skeletal muscle: insulin stimulates translocation of both alpha 1- and alpha 2-subunit isoforms.

  FEBS letters 20030211

• Pro-collagen I COOH-terminal trimer induces directional migration and metalloproteinases in breast cancer cells.

  The Journal of biological chemistry 20030207

• Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.

  The Journal of biological chemistry 20030207

• Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival.

  The Journal of biological chemistry 20030207

• Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

  Journal of molecular biology 20030207

• Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium.

  Circulation research 20030207

• Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway.

  Journal of the American College of Cardiology 20030205

• NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells.

  American journal of physiology. Cell physiology 20030201

• Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism.

  American journal of physiology. Gastrointestinal and liver physiology 20030201

• Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase.

  American journal of physiology. Heart and circulatory physiology 20030201

• Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes.

  Blood 20030201

• Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase in endothelial cell.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

• Analysis of hormone-stimulated phosphatidylinositol synthesis.

  Journal of cellular physiology 20030201

• Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide.

  Molecular pharmacology 20030201

• Role of phosphoinositide 3-kinase in the nonselective cation channel activation by endothelin-1/endothelinB receptor.

  American journal of physiology. Cell physiology 20030201

• Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.

  Endocrinology 20030201

• Inhibition of nucleoside transport by protein kinase inhibitors.

  The Journal of pharmacology and experimental therapeutics 20030201

• Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase.

  American journal of respiratory cell and molecular biology 20030201

• Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell chemotaxis.

  Diabetes 20030201

• Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

• Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.

  Experimental biology and medicine (Maywood, N.J.) 20030201

• Leptin administration normalizes insulin secretion from islets of Lep(ob)/Lep(ob) mice by food intake-dependent and -independent mechanisms.

  Experimental biology and medicine (Maywood, N.J.) 20030201

• Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.

  Anti-cancer drugs 20030201

• Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanisms.

  Journal of neuroimmunology 20030201

• Steroidogenic responses of pig corpora lutea to insulin-like growth factor I (IGF-I) throughout the oestrous cycle.

  Reproduction (Cambridge, England) 20030201

• Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation.

  Leukemia 20030201

• Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS.

  Journal of molecular and cellular cardiology 20030201

• Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation.

  Molecular psychiatry 20030201

• Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.

  The Tohoku journal of experimental medicine 20030201

• Mammalian phosphatidylinositol 4-kinases.

  IUBMB life 20030201

• Impedance of Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis by peroxisome proliferator-activated receptor gamma activation involves phosphatidylinositol 3-kinase/ERK pathway.

  IUBMB life 20030201

• Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK.

  Oncogene 20030130

• A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors.

  British journal of cancer 20030127

• Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion.

  International journal of cancer 20030120

• Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity.

  FEBS letters 20030116

• Insulin stimulation of pyruvate dehydrogenase in adipocytes involves two distinct signalling pathways.

  The Biochemical journal 20030115

• Phosphoinositide-3-kinase-independent contractile activities associated with Fcgamma-receptor-mediated phagocytosis and macropinocytosis in macrophages.

  Journal of cell science 20030115

• Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.

  Experimental cell research 20030115

• The role of phosphatidylinositol 3-kinase (PI3K) in CO2 stimulation of the Na+/HCO3- cotransporter (NBC).

  The Journal of membrane biology 20030115

• LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin.

  The Journal of biological chemistry 20030110

• Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity.

  The Journal of biological chemistry 20030110

• Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.

  The Journal of biological chemistry 20030103

• Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.

  The Journal of biological chemistry 20030103

• A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.

  The Journal of biological chemistry 20030103

• 17alpha-estradiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway.

  Biochemical and biophysical research communications 20030103

• PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum.

  American journal of physiology. Gastrointestinal and liver physiology 20030101

• Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.

  Cellular signalling 20030101

• Engagement of PI-3-kinase mediated protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis.

  International journal of oncology 20030101

• Wortmannin enhances the induction of micronuclei by low and high LET radiation.

  Mutagenesis 20030101

• Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.

  The Journal of pharmacology and experimental therapeutics 20030101

• Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation.

  Diabetes 20030101

• Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil.

  Anesthesiology 20030101

• HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells.

  Cardiovascular research 20030101

• Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation.

  Acta pharmacologica Sinica 20030101

• Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

  Cancer research 20030101

• [G-protein-coupled muscarinic acetylcholine receptor activation up-regulates Bcl-2 and phospho-bad via Ras-ERK-1/2 signaling pathway].

  Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20030101

• Lysis of salmonella typhi intracellularly infected U937 cells by human natural killer cells: effect of protein kinase inhibitors.

  American journal of therapeutics 20030101

• Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity.

  Carcinogenesis 20030101

• Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J.

  International journal of radiation biology 20030101

• The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells.

  Molecular cancer research : MCR 20030101

• Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3-kinase signalling.

  Genes to cells : devoted to molecular & cellular mechanisms 20030101

• The involvement of lipid activators of protein kinase C in the induction of ZIF268 in PC12 cells exposed to lead.

  Neurochemical research 20030101

• Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover.

  European journal of immunology 20030101

• Membrane-bound form of fractalkine induces IFN-gamma production by NK cells.

  European journal of immunology 20030101

• Apoptosis: targets in pancreatic cancer.

  Molecular cancer 20030101

• Short-term stretch translocates the alpha-1-subunit of the Na pump to plasma membrane.

  Cell biochemistry and biophysics 20030101

• Src tyrosine kinase but not activated Ras augments sensitivity to taxanes through apoptosis in human adenocarcinoma cells.

  Anticancer research 20030101

• A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.

  Neuroscience 20030101

• Molecular responses to hypoxia in tumor cells.

  Molecular cancer 20030101

• Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation.

  Advances in enzyme regulation 20030101

• Photodynamic inactivation of isolated crayfish neuron requires protein kinase C, PI 3-kinase and Ca2+.

  Journal of photochemistry and photobiology. B, Biology 20030101

• Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes.

  Pathology oncology research : POR 20030101

• Effects of p53 status and wortmannin treatment on potentially lethal damage repair, with emphasis on the response of intratumor quiescent cells.

  Radiation medicine 20030101

• Role of ERK, p38 and PI3-kinase in EGF receptor-mediated mitogenic signalling in cultured rat hepatocytes: requirement for sustained ERK activation.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

• Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

• Growth-inhibitory effect of phosphatidylinositol 3-kinase inhibitor on human pancreatic cancer cells and expression of Bcl-2 family.

  Anticancer research 20030101

• [Signaling pathways that control the growth and survival of prostate tumor cells in the absence of androgens].

  Molekuliarnaia biologiia 20030101

• [The role of phosphatidylinositol-3-kinases P85/P110 and hVPS34 in endocytosis of EGF-receptor complexes].

  Tsitologiia 20030101

• Receptor-mediated biphasic alteration of hepatocellular transport from hepatocyte to bile canaliculi as measured by near-infrared spectroscopy: a novel test with glucagon for biliary excretion.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20030101

• Insulin-like growth factor-1 in myocardial tissue: interaction with tumor necrosis factor.

  Critical care (London, England) 20030101

• Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury.

  Critical care (London, England) 20030101

• DNA end sequestration by DNA-dependent protein kinase and end joining of sterically constrained substrates in whole-cell extracts.

  Environmental and molecular mutagenesis 20030101

• Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer.

  Oncology 20030101

• Agonist concentration-dependent differential responsivity of a human platelet purinergic receptor: pharmacological and kinetic studies of aggregation, deaggregation and shape change responses mediated by the purinergic P2Y1 receptor in vitro.

  Platelets 20030101

• Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway.

  Molecular medicine (Cambridge, Mass.) 20030101

• DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin.

  Mutation research 20021229

• Chemokine-independent preference for T-helper-1 cells in transendothelial migration.

  The Journal of biological chemistry 20021227

• Cholecystokinin-stimulated tyrosine phosphorylation of PKC-delta in pancreatic acinar cells is regulated bidirectionally by PKC activation.

  Biochimica et biophysica acta 20021216

• Total synthesis of (+/-)-wortmannin.

  Angewandte Chemie (International ed. in English) 20021216

• Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.

  The Biochemical journal 20021215

• Inhibition of autophagic proteolysis by inhibitors of phosphoinositide 3-kinase can interfere with the regulation of glycogen synthesis in isolated hepatocytes.

  The Biochemical journal 20021215

• Intracellular signaling involved in macrophage adhesion and FBGC formation as mediated by ligand-substrate interaction.

  Journal of biomedical materials research 20021215

• Activation of JNK by TPA promotes apoptosis via PKC pathway in gastric cancer cells.

  World journal of gastroenterology 20021215

• Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.

  The Journal of physiology 20021215

• Effects of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one on synaptic vesicle cycling at the frog neuromuscular junction.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021215

• Cellular conditioning and activation of beta-catenin signaling by the FPB prostanoid receptor.

  The Journal of biological chemistry 20021213

• Endocytosed transferrin receptors recycle via distinct dynamin and phosphatidylinositol 3-kinase-dependent pathways.

  The Journal of biological chemistry 20021213

• The role of myosin in vesicle transport during bovine chromaffin cell secretion.

  The Biochemical journal 20021201

• alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta.

  The Biochemical journal 20021201

• Protective effect of adrenomedullin in mannitol-induced apoptosis.

  Apoptosis : an international journal on programmed cell death 20021201

• Mechanism by which cAMP activates PI3-kinase and increases bile acid secretion in WIF-B9 cells.

  American journal of physiology. Cell physiology 20021201

• Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.

  British journal of pharmacology 20021201

• Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.

  Molecular pharmacology 20021201

• Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta.

  The Journal of pharmacology and experimental therapeutics 20021201

• Intracellular trafficking of human CXCR1 and CXCR2: regulation by receptor domains and actin-related kinases.

  European journal of immunology 20021201

• Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20021201

• Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles.

  Cardiovascular research 20021201

• The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase.

  Endocrinology 20021201

• Inhibition of autophagy in mitotic animal cells.

  Traffic (Copenhagen, Denmark) 20021201

• Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 beta protein.

  Diabetes 20021201

• Effect of glimepiride on insulin-stimulated glycogen synthesis in cultured human skeletal muscle cells: a comparison to glibenclamide.

  Diabetes care 20021201

• Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation.

  Gastroenterology 20021201

• Role of phosphatidylinositol 3-kinase in the binding of Bordetella pertussis to human monocytes.

  Cellular microbiology 20021201

• Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells.

  The Journal of general virology 20021201

• Signal transduction mechanism leading to enhanced proliferation of primary cultured adult rat hepatocytes treated with royal jelly 57-kDa protein.

  Journal of biochemistry 20021201

• Binding and invasion of HeLa and MRC-5 cells by Streptococcus agalactiae.

  Microbiology (Reading, England) 20021201

• Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.

  Nature 20021201

• Stimulation of 14-3-3 protein and its isoform on histamine secretion from permeabilized rat peritoneal mast cells.

  Biological & pharmaceutical bulletin 20021201

• IL-1beta-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1.

  European journal of immunology 20021201

• Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20021201

• Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.

  Molecular medicine (Cambridge, Mass.) 20021201

• Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes.

  Chinese medical journal 20021201

• Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway.

  Cellular immunology 20021201

• Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.

  The Journal of biological chemistry 20021122

• Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf.

  FEBS letters 20021120

• An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phosphatidylinositol 3-kinase.

  The Biochemical journal 20021115

• Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide.

  The Journal of biological chemistry 20021115

• Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells.

  Biochemical and biophysical research communications 20021115

• Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines.

  Cancer research 20021115

• Nonrequirement of continuous stimulation with MCP-1 for cell migration and determination of directional migration by initial stimulation with chemokine.

  Experimental cell research 20021115

• Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton.

  The Journal of biological chemistry 20021108

• Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo.

  The Journal of biological chemistry 20021108

• Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway.

  Oncogene 20021107

• The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism.

  FEBS letters 20021106

• Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635.

  The Journal of biological chemistry 20021101

• Interleukin-1beta-induced cyclooxygenase-2 expression is mediated through activation of p42/44 and p38 MAPKS, and NF-kappaB pathways in canine tracheal smooth muscle cells.

  Cellular signalling 20021101

• Inhibition of apical Cl-/OH- exchange activity in Caco-2 cells by phorbol esters is mediated by PKCepsilon.

  American journal of physiology. Cell physiology 20021101

• Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism.

  American journal of physiology. Heart and circulatory physiology 20021101

• Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases.

  Journal of cellular physiology 20021101

• Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is involved in the activation of endothelial integrins.

  Journal of cellular physiology 20021101

• Phosphatidylinositol-3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes.

  Journal of neurochemistry 20021101

• Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.

  Molecular pharmacology 20021101

• The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase.

  Anesthesia and analgesia 20021101

• Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.

  Hypertension (Dallas, Tex. : 1979) 20021101

• Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues.

  The American journal of pathology 20021101

• Lipoarabinomannan-induced cell signaling involves ceramide and mitogen-activated protein kinase.

  Clinical and diagnostic laboratory immunology 20021101

• Autocrine signaling through Ras regulates cell survival activity in human glioma cells: potential cross-talk between Ras and the phosphatidylinositol 3-kinase-Akt pathway.

  Journal of neuropathology and experimental neurology 20021101

• Insulin influences the nitric oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric oxide synthase.

  European journal of endocrinology 20021101

• The phosphotidyl inositol 3-kinase/Akt signal pathway is involved in interleukin-6-mediated Mcl-1 upregulation and anti-apoptosis activity in basal cell carcinoma cells.

  The Journal of investigative dermatology 20021101

• Membrane sorting during swimming internalization of Brucella is required for phagosome trafficking decisions.

  Microbial pathogenesis 20021101

• Polysaccharide part of Proteus mirabilis lipopolysaccharide may be responsible for the stimulation of platelet adhesion to collagen.

  Platelets 20021101

• ['Death and survival of neuronal cells exposed to Alzheimer's disease-relevant insults'].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101

• Fermented milk, Kefram-Kefir enhances glucose uptake into insulin-responsive muscle cells.

  Cytotechnology 20021101

• N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A.

  The Journal of biological chemistry 20021018

• Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthase.

  The Journal of biological chemistry 20021018

• Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor.

  Cell 20021018

• Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor.

  Blood 20021015

• Thrombin induces mast cell adhesion to fibronectin: evidence for involvement of protease-activated receptor-1.

  Journal of immunology (Baltimore, Md. : 1950) 20021015

• Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.

  Experimental cell research 20021015

• DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line.

  World journal of gastroenterology 20021015

• Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021015

• IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines.

  The Journal of biological chemistry 20021011

• Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway.

  The Journal of biological chemistry 20021011

• ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation.

  The Journal of biological chemistry 20021011

• Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors.

  The Journal of biological chemistry 20021011

• Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages.

  The Journal of biological chemistry 20021011

• Negative regulation of urokinase-type plasminogen activator production through FGF-2-mediated activation of phosphoinositide 3-kinase.

  Oncogene 20021010

• Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator.

  The Biochemical journal 20021001

• Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis.

  The Biochemical journal 20021001

• Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells.

  Cellular signalling 20021001

• Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation.

  American journal of physiology. Lung cellular and molecular physiology 20021001

• TSH signaling and cell survival in 3T3-L1 preadipocytes.

  American journal of physiology. Cell physiology 20021001

• Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36.

  Diabetes 20021001

• PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.

  Gastroenterology 20021001

• Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats.

  Gastroenterology 20021001

• Phosphatidylinositol 3- and 4-phosphate are required for normal stomatal movements.

  The Plant cell 20021001

• Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

• Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

• Wortmannin inhibits growth of human non-small-cell lung cancer in vitro and in vivo.

  Langenbeck's archives of surgery 20021001

• Constitutive activation of p70S6k in cancer cells.

  Archives of pharmacal research 20021001

• Cholinergic activation of glucose transport in bovine chromaffin cells involves calmodulin and protein kinase Czeta signaling.

  Annals of the New York Academy of Sciences 20021001

• Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.

  Molecular cancer therapeutics 20021001

• Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells.

  Molecular cancer therapeutics 20021001

• [Effect of metformin on gene expression of phosphoenolpyruvate carboxykinase].

  Zhonghua nei ke za zhi 20021001

• A versatile high-throughput screen for inhibitors of lipid kinase activity: development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma.

  Journal of biomolecular screening 20021001

• Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells.

  The Journal of biological chemistry 20020927

• Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells.

  The Journal of biological chemistry 20020927

• Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.

  Oncogene 20020926

• Phosphoinositide 3-kinase C2alpha is activated upon smooth muscle cell migration and regulated by alpha(v)beta(3) integrin engagement.

  Biochemical and biophysical research communications 20020920

• The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit.

  Oncogene 20020919

• Elevated Akt phosphorylation as an indicator of renal tubular epithelial cell stress.

  The Journal of biological chemistry 20020913

• Ku affects the ATM-dependent S phase checkpoint following ionizing radiation.

  Oncogene 20020912

• End-joining of reconstituted histone H2AX-containing chromatin in vitro by soluble nuclear proteins from human cells.

  FEBS letters 20020911

• The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution.

  The Journal of biological chemistry 20020906

• Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel.

  The Journal of biological chemistry 20020906

• Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators.

  Circulation research 20020906

• TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.

  Cellular signalling 20020901

• Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3).

  Cell biochemistry and function 20020901

• Selective regulation of the Rab9-independent transport of ricin to the Golgi apparatus by calcium.

  Journal of cell science 20020901

• Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells.

  Archives of biochemistry and biophysics 20020901

• Na(+)/H(+) exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells.

  American journal of physiology. Cell physiology 20020901

• Acid-base effects on intestinal Na(+) absorption and vesicular trafficking.

  American journal of physiology. Cell physiology 20020901

• Effects of phosphoinositide 3-kinase on the endothelin-1-induced activation of voltage-independent Ca(2+) channels and mitogenesis in Chinese hamster ovary cells stably expressing endothelin(a) receptor.

  Molecular pharmacology 20020901

• Characterization of the beta-adrenoceptor subtype involved in mediation of glucose transport in L6 cells.

  British journal of pharmacology 20020901

• Src tyrosine kinase-induced loss of luteinizing hormone responsiveness is via a Ras-dependent, phosphatidylinositol-3-kinase independent pathway.

  Biology of reproduction 20020901

• Müllerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation.

  Endocrinology 20020901

• Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.

  Diabetes 20020901

• The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells.

  American journal of respiratory cell and molecular biology 20020901

• Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.

  Cancer research 20020901

• Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8.

  Journal of leukocyte biology 20020901

• Evidence for phosphatidylinositol 3-kinase-Akt-p7S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in meningioma cells.

  Journal of neurosurgery 20020901

• Activity-dependent NMDA receptor-mediated activation of protein kinase B/Akt in cortical neuronal cultures.

  Journal of neurochemistry 20020901

• Aniracetam attenuates apoptosis of astrocytes subjected to simulated ischemia in vitro.

  Neurotoxicology 20020901

• The phosphatidylinositol-3 kinase pathway is not essential for insulin-like growth factor I receptor-mediated clonogenic radioresistance.

  Journal of radiation research 20020901

• Involvement of type I protein kinase A in the differentiation of L6 myoblast in conjunction with phosphatidylinositol 3-kinase.

  Molecules and cells 20020831

• Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.

  The Journal of biological chemistry 20020830

• Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.

  The Journal of biological chemistry 20020830

• Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway.

  Biochemical and biophysical research communications 20020830

• Activation of PI 3-kinase by the hexosamine biosynthesis pathway.

  Molecular and cellular endocrinology 20020830

• Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

  Oncogene 20020829

• Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats.

  Circulation research 20020823

• The role of non-ionic surfactants on cationic lipid mediated gene transfer.

  Journal of controlled release : official journal of the Controlled Release Society 20020821

• Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.

  International journal of cancer 20020820

• Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis.

  The Journal of biological chemistry 20020816

• Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A.

  The Journal of biological chemistry 20020816

• Akt is a downstream target of NF-kappa B.

  The Journal of biological chemistry 20020816

• Stem cell factor modulates paired-pulse facilitation and long-term potentiation in the hippocampal mossy fiber-CA3 pathway in mice.

  Brain research 20020816

• Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes.

  Brain research 20020816

• Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1.

  The Biochemical journal 20020815

• Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

  Blood 20020815

• Lactosylceramide-enriched glycosphingolipid signaling domain mediates superoxide generation from human neutrophils.

  Blood 20020815

• Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase.

  Cardiovascular research 20020815

• Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines.

  Oncogene 20020815

• PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes.

  Experimental cell research 20020815

• Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation.

  Cancer research 20020815

• Beta 1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway.

  Cancer 20020815

• Possible involvement of tetrahydrobiopterin in the trophic effect of insulin-like growth factor-1 on rat pheochromocytoma-12 (PC12) cells.

  Neuroscience letters 20020809

• Alpha1-adrenoceptor-mediated breakdown of phosphatidylinositol 4,5-bisphosphate inhibits pinacidil-activated ATP-sensitive K+ currents in rat ventricular myocytes.

  Circulation research 20020809

• Acetylcholine-induced phosphatidylinositol 4,5-bisphosphate depletion does not cause short-term desensitization of G protein-gated inwardly rectifying K+ current in mouse atrial myocytes.

  The Journal of biological chemistry 20020802

• Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes.

  The Biochemical journal 20020801

• GSK-3beta negatively regulates skeletal myotube hypertrophy.

  American journal of physiology. Cell physiology 20020801

• TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK.

  American journal of physiology. Lung cellular and molecular physiology 20020801

• Studies of the mitogen-activated protein kinases and phosphatidylinositol-3 kinase in the lens. 2. The intercommunications.

  Experimental eye research 20020801

• YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway.

  Molecular microbiology 20020801

• Phosphatidylinositol 3-kinases are involved in the all-trans retinoic acid-induced upregulation of CD38 antigen on human haematopoietic cells.

  British journal of haematology 20020801

• Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization.

  Journal of leukocyte biology 20020801

• Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism.

  Toxicological sciences : an official journal of the Society of Toxicology 20020801

• Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase.

  Cancer research 20020801

• Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells.

  The American journal of pathology 20020801

• Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion.

  Journal of neurophysiology 20020801

• Regulation of rat Sertoli cell function by FSH: possible role of phosphatidylinositol 3-kinase/protein kinase B pathway.

  The Journal of endocrinology 20020801

• Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.

  The Journal of endocrinology 20020801

• Inhibitors of phosphatidylinositol 3-kinase amplify insulin release from islets of lean but not obese mice.

  The Journal of endocrinology 20020801

• Comparison of phytotoxicity and mammalian cytotoxicity of nontrichothecene mycotoxins.

  Journal of natural toxins 20020801

• Iron targeting to mitochondria in erythroid cells.

  Biochemical Society transactions 20020801

• Roles of tyrosine kinase-, 1-phosphatidylinositol 3-kinase-, and mitogen-activated protein kinase-signaling pathways in ethanol-induced contractions of rat aortic smooth muscle: possible relation to alcohol-induced hypertension.

  Alcohol (Fayetteville, N.Y.) 20020801

• Dieldrin induces human neutrophil superoxide production via protein kinases C and tyrosine kinases.

  Human & experimental toxicology 20020801

• Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma.

  Molecular cancer therapeutics 20020801

• Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta.

  Cancer letters 20020726

• DNA damage response pathway in radioadaptive response.

  Mutation research 20020725

• Effects of glucose, exogenous insulin, and carbachol on C-peptide and insulin secretion from isolated perifused rat islets.

  The Journal of biological chemistry 20020719

• Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.

  Experimental cell research 20020715

• Human neutrophil-expressed CD28 interacts with macrophage B7 to induce phosphatidylinositol 3-kinase-dependent IFN-gamma secretion and restriction of Leishmania growth.

  Journal of immunology (Baltimore, Md. : 1950) 20020715

• Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90.

  Cancer research 20020715

• Comparison between the effects of the rapid recombinant insulin analog aspart and those of human regular insulin on platelet cyclic nucleotides and aggregation.

  Thrombosis research 20020715

• HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.

  The Journal of biological chemistry 20020712

• Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2.

  The Journal of biological chemistry 20020712

• 1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase.

  Circulation research 20020712

• Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation.

  Circulation research 20020712

• Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88.

  The Journal of biological chemistry 20020705

• A novel pathway for nickel-induced interleukin-8 expression.

  The Journal of biological chemistry 20020705

• Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24.

  Traffic (Copenhagen, Denmark) 20020701

• ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells.

  American journal of physiology. Cell physiology 20020701

• Phosphatidylinositol 3-kinase-dependent, MEK- independent proliferation in response to CaR activation.

  American journal of physiology. Cell physiology 20020701

• Myosin X is a downstream effector of PI(3)K during phagocytosis.

  Nature cell biology 20020701

• Phosphoinositide 3-kinase mediates protein kinase C beta II mRNA destabilization in rat A10 smooth muscle cell cultures exposed to high glucose.

  Archives of biochemistry and biophysics 20020701

• Role of Ca2+-activated Cl- channels and MLCK in slow IJP in opossum esophageal smooth muscle.

  American journal of physiology. Gastrointestinal and liver physiology 20020701

• The unique property of the CC chemokine regakine-1 to synergize with other plasma-derived inflammatory mediators in neutrophil chemotaxis does not reside in its NH2-terminal structure.

  Molecular pharmacology 20020701

• GH and epidermal growth factor signaling in normal and Laron syndrome fibroblasts.

  Endocrinology 20020701

• Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells.

  Microvascular research 20020701

• Cytokines modulate telomerase activity in a human multiple myeloma cell line.

  Cancer research 20020701

• Phosphatidylinositol 3-kinase and extracellular signal-regulated kinase are recruited for Fc receptor-mediated phagocytosis during monocyte-to-macrophage differentiation.

  Journal of leukocyte biology 20020701

• Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway.

  Journal of leukocyte biology 20020701

• Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation.

  Archives of dermatological research 20020701

• Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.

  European journal of immunology 20020701

• LY294002, but not wortmannin, increases intracellular calcium and inhibits calcium transients in bovine and human airway smooth muscle cells.

  Cell calcium 20020701

• Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.

  Toxicology and applied pharmacology 20020701

• The role of protein kinase C in the transient association of p57, a coronin family actin-binding protein, with phagosomes.

  Biological & pharmaceutical bulletin 20020701

• Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line.

  Experimental hematology 20020701

• The effect of epidermal growth factor on vascular endothelial growth factor secretion by endometrial stromal cells.

  Clinical and experimental medicine 20020701

• Evidence that the platelet integrin alphaIIb beta3 is regulated by the integrin-linked kinase, ILK, in a PI3-kinase dependent pathway.

  Thrombosis and haemostasis 20020701

• Intrahippocampal wortmannin infusion enhances long-term spatial and contextual memories.

  Learning & memory (Cold Spring Harbor, N.Y.) 20020701

• Human GM-CSF induces HIV-1 LTR by multiple signalling pathways.

  Biochimie 20020701

• Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts.

  Molecules and cells 20020630

• Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport.

  The Journal of biological chemistry 20020628

• Transendothelial migratory pathways of V delta 1+TCR gamma delta+ and V delta 2+TCR gamma delta+ T lymphocytes from healthy donors and multiple sclerosis patients: involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II.

  Journal of immunology (Baltimore, Md. : 1950) 20020615

• Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.

  The Journal of physiology 20020615

• Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.

  Brain research. Molecular brain research 20020615

• Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases.

  The Journal of biological chemistry 20020614

• EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness.

  International journal of cancer 20020610

• Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor.

  The Journal of biological chemistry 20020607

• Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine.

  The Journal of biological chemistry 20020607

• Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells.

  Biochemical and biophysical research communications 20020607

• Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP.

  The Prostate 20020601

• Myosin light chain phosphorylation facilitates in vivo myosin filament reassembly after mechanical perturbation.

  American journal of physiology. Cell physiology 20020601

• Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activity.

  American journal of physiology. Renal physiology 20020601

• Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension.

  American journal of physiology. Heart and circulatory physiology 20020601

• Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase.

  Cell death and differentiation 20020601

• Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca(2+)-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.

  Journal of biochemistry 20020601

• PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning.

  Journal of molecular and cellular cardiology 20020601

• Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020601

• Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein.

  Experimental neurology 20020601

• Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.

  International journal of radiation biology 20020601

• PKC and Raf-1 inhibition-related apoptotic signalling in N2a cells.

  Journal of neurochemistry 20020601

• Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts.

  Arthritis and rheumatism 20020601

• Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, phosphatidylinositol 3-kinase, and p70 S6K.

  Canadian journal of physiology and pharmacology 20020601

• Tyrosine phosphatase CD45 regulates hydrogen peroxide-induced calcium mobilization in B cells.

  Antioxidants & redox signaling 20020601

• Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species.

  The Journal of biological chemistry 20020531

• Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways.

  The Journal of biological chemistry 20020531

• Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells.

  The Journal of biological chemistry 20020531

• Regulatory role for SRC and phosphatidylinositol 3-kinase in initiation of fibronectin matrix assembly.

  The Journal of biological chemistry 20020531

• Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.

  The Journal of biological chemistry 20020531

• Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway.

  The Journal of biological chemistry 20020531

• Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes.

  The Journal of biological chemistry 20020524

• Phosphatidylinositol 3-kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells.

  Life sciences 20020524

• Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils.

  Biochemical and biophysical research communications 20020524

• AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival.

  Oncogene 20020516

• The dynamics of plasma membrane PtdIns(4,5)P(2) at fertilization of mouse eggs.

  Journal of cell science 20020515

• The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c.

  The Journal of biological chemistry 20020510

• Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.

  The Journal of biological chemistry 20020503

• Signaling pathways involved in the physiological response of mussel hemocytes to bacterial challenge: the role of stress-activated p38 MAP kinases.

  Developmental and comparative immunology 20020501

• Phagocyte spreading and phagocytosis in the compound ascidian Botryllus schlosseri: evidence for an integrin-like, RGD-dependent recognition mechanism.

  Developmental and comparative immunology 20020501

• CD28 costimulation induces delta opioid receptor expression during anti-CD3 activation of T cells.

  Journal of immunology (Baltimore, Md. : 1950) 20020501

• Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1.

  Journal of immunology (Baltimore, Md. : 1950) 20020501

• Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501

• Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.

  The EMBO journal 20020501

• Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.

  Investigative ophthalmology & visual science 20020501

• Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

  Leukemia 20020501

• Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells.

  The Journal of clinical endocrinology and metabolism 20020501

• Recognition and phagocytosis of apoptotic T cells by resident murine tissue macrophages require multiple signal transduction events.

  Journal of leukocyte biology 20020501

• Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of (18)F-FDG PET images.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020501

• Antiapoptotic effects induced by different wavelengths of ultraviolet light.

  Photochemistry and photobiology 20020501

• Nongenomic action of 1 alpha,25(OH)(2)-vitamin D3. Activation of muscle cell PLC gamma through the tyrosine kinase c-Src and PtdIns 3-kinase.

  European journal of biochemistry 20020501

• Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020501

• In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020501

• Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase.

  Journal of neurochemistry 20020501

• Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells.

  Immunopharmacology and immunotoxicology 20020501

• Red blood cell Na+/H+ exchange activity is insulin resistant in hypertensive patients.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20020501

• Protein kinases mediate nitric oxide-induced apoptosis in the insect cell line IPLB-LdFB.

  Cellular and molecular life sciences : CMLS 20020501

• Generation of reactive oxygen species in blood platelets.

  Platelets 20020501

• A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells.

  The Histochemical journal 20020501

• Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells.

  Cytokine 20020421

• Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

  The Journal of biological chemistry 20020419

• Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.

  The Journal of biological chemistry 20020419

• The role of PI 3-kinase in the UVB-induced expression of c-fos.

  Oncogene 20020418

• Lysophosphatidic acid and receptor-mediated activation of endothelial nitric-oxide synthase.

  Biochemistry 20020416

• Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways.

  Circulation 20020416

• Activation of extracellular signal regulated protein kinase by neuropeptide Y and pancreatic polypeptide in CHO cells expressing the NPY Y(1), Y(2), Y(4) and Y(5) receptor subtypes.

  Regulatory peptides 20020415

• beta1 and beta2 integrins activate different signalling pathways in monocytes.

  The Biochemical journal 20020415

• Early events in the activation of Fc gamma RIIA in human neutrophils: stimulated insolubilization, translocation to detergent-resistant domains, and degradation of Fc gamma RIIA.

  Journal of immunology (Baltimore, Md. : 1950) 20020415

• Phosphatidylinositol kinase enzymes regulate the retrograde axonal transport of NT-3 and NT-4 in sympathetic and sensory neurons.

  Journal of neuroscience research 20020415

• Nuclear localization of phosphatidylinositol 4-kinase beta.

  Journal of cell science 20020415

• Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase.

  The Journal of biological chemistry 20020412

• Role of 3-phosphoinositides in the maturation of Salmonella-containing vacuoles within host cells.

  The Journal of biological chemistry 20020412

• ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.

  The Journal of biological chemistry 20020412

• Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity.

  British journal of cancer 20020408

• Contraction regulation of Akt in rat skeletal muscle.

  The Journal of biological chemistry 20020405

• Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway.

  Biochemical and biophysical research communications 20020405

• Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors.

  Circulation research 20020405

• Insulin-like growth factor-1 increases activity and surface levels of the GLAST subtype of glutamate transporter.

  Neurochemistry international 20020401

• Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway.

  Cellular signalling 20020401

• Actin cytoskeletal modulation of pressure-induced depolarization and Ca(2+) influx in cerebral arteries.

  American journal of physiology. Heart and circulatory physiology 20020401

• Paradoxical regulation of Sp1 transcription factor by glucagon.

  Endocrinology 20020401

• Preferential binding of Grb2 or phosphatidylinositol 3-kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation.

  Experimental cell research 20020401

• Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.

  The Biochemical journal 20020401

• Interaction between Src homology 2 domain bearing protein tyrosine phosphatase substrate-1 and CD47 mediates the adhesion of human B lymphocytes to nonactivated endothelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20020401

• Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways.

  Molecular endocrinology (Baltimore, Md.) 20020401

• Effect of semi-synthesized quercetin water-soluble derivatives on recombinant human phosphatidylinositol 3-kinase p110beta catalytic subunit.

  Acta pharmacologica Sinica 20020401

• The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells.

  European journal of immunology 20020401

• Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1MF-2 smooth muscle cells.

  British journal of pharmacology 20020401

• Expression and regulation of endothelial nitric oxide synthase by vascular endothelial growth factor in ECV 304 cells.

  Journal of Korean medical science 20020401

• Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death.

  Journal of molecular and cellular cardiology 20020401

• Physiologic levels of epidermal growth factor in saliva stimulate cell migration of an oral epithelial cell line, HO-1-N-1.

  European journal of oral sciences 20020401

• Tuning of T cell clone size and activation threshold by control of CD25 expression through mitogen-activated protein kinase pathways.

  International archives of allergy and immunology 20020401

• The initial inositol 1,4,5-trisphosphate response induced by histamine is strongly amplified by Ca(2+) release from internal stores in smooth muscle.

  Cell calcium 20020401

• Involvement of phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii.

  General and comparative endocrinology 20020401

• Effects of modulators of protein phosphorylation on heme metabolism in human hepatic cells: induction of delta-aminolevulinic synthase mRNA and protein by okadaic acid.

  DNA and cell biology 20020401

• Neuroprotection by scatter factor/hepatocyte growth factor and FGF-1 in cerebellar granule neurons is phosphatidylinositol 3-kinase/akt-dependent and MAPK/CREB-independent.

  Journal of neurochemistry 20020401

• [Correlation between inhibitory effect of Manumycin on human hepatoma cancer cell HepG2 and Ras signal transduction pathway].

  Ai zheng = Aizheng = Chinese journal of cancer 20020401

• Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats.

  Molecular and cellular endocrinology 20020328

• Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.

  FEBS letters 20020327

• Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation.

  Circulation 20020326

• Ortho-substituted polybrominated biphenyls activate respiratory burst in granulocytes from humans.

  Toxicology letters 20020324

• Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation.

  The Journal of biological chemistry 20020322

• Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration.

  The Journal of biological chemistry 20020322

• Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene.

  Circulation 20020319

• Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.

  The Journal of biological chemistry 20020315

• Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins.

  The Journal of biological chemistry 20020315

• Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.

  The Biochemical journal 20020315

• Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion from human dermal microvascular endothelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20020315

• An ATM-independent S-phase checkpoint response involves CHK1 pathway.

  Cancer research 20020315

• Overexpression of PEMT2 downregulates the PI3K/Akt signaling pathway in rat hepatoma cells.

  Biochimica et biophysica acta 20020315

• Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes.

  FEBS letters 20020313

• Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide 3-kinase.

  The Journal of biological chemistry 20020308

• Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotective.

  Circulation research 20020308

• Thrombin-stimulated cell proliferation mediated through activation of Ras/Raf/MEK/MAPK pathway in canine cultured tracheal smooth muscle cells.

  Cellular signalling 20020301

• Mechanisms transducing the aldosterone secretagogue signal of endothelins in the human adrenal cortex.

  Peptides 20020301

• Real-time analysis of ligand-induced cell surface and intracellular reactions of living mast cells using a surface plasmon resonance-based biosensor.

  Analytical biochemistry 20020301

• Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation.

  Molecular pharmacology 20020301

• Regulation of cap-dependent translation by insulin-like growth factor-1 in neuronal cells.

  Biochemical and biophysical research communications 20020301

• Effects of hyperthermia on p53 protein expression and activity.

  Journal of cellular physiology 20020301

• Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes.

  Endocrinology 20020301

• High glucose levels increase major histocompatibility complex class I gene expression in thyroid cells and amplify interferon-gamma action.

  Endocrinology 20020301

• Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase.

  The Journal of pharmacology and experimental therapeutics 20020301

• Beta(3)-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: inhibition by HIV-1 Tat.

  Journal of leukocyte biology 20020301

• Insulin and isoproterenol differentially regulate mitogen-activated protein kinase-dependent Na(+)-K(+)-2Cl(-) cotransporter activity in skeletal muscle.

  Diabetes 20020301

• 14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.

  Molecular endocrinology (Baltimore, Md.) 20020301

• Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway.

  Arteriosclerosis, thrombosis, and vascular biology 20020301

• Phosphatidylinositol 3-kinase may mediate isoproterenol-induced vascular relaxation in part through nitric oxide production.

  Metabolism: clinical and experimental 20020301

• Involvement of phosphatidylinositol-3-kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells.

  Biochemical pharmacology 20020301

• The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling.

  Genes to cells : devoted to molecular & cellular mechanisms 20020301

• Leucocyte chemotaxis: Examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by Monocyte Chemoattractant Proteins-1, -2, -3 and -4.

  Clinical and experimental immunology 20020301

• [Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase influences neurotrophin-induced spiral ganglion neurite growth].

  Laryngo- rhino- otologie 20020301

• Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.

  Biochemistry. Biokhimiia 20020301

• Acute stimulation of glucose uptake by leptin in l6 muscle cells.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020301

• Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells.

  Immunobiology 20020301

• Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidyl-inositol-3-kinase pathway in the rat heart.

  Basic research in cardiology 20020301

• 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons.

  Neuron 20020227

• Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization.

  The Journal of biological chemistry 20020222

• Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells.

  The Journal of biological chemistry 20020222

• E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts.

  The Journal of biological chemistry 20020222

• Insulin and isoproterenol have opposing roles in the maintenance of cytosol pH and optimal fusion of GLUT4 vesicles with the plasma membrane.

  The Journal of biological chemistry 20020222

• Insulin stimulates nitric oxide production in rat adipocytes.

  Biochemical and biophysical research communications 20020222

• Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses.

  Oncogene 20020221

• ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation.

  The Journal of biological chemistry 20020215

• IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution.

  The EMBO journal 20020215

• Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1.

  The Journal of biological chemistry 20020208

• Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway.

  Circulation research 20020208

• TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway.

  Oncogene 20020207

• Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca(2+) entry.

  Current biology : CB 20020205

• Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator.

  The Journal of biological chemistry 20020201

• Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR.

  The Journal of biological chemistry 20020201

• Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A.

  The Journal of biological chemistry 20020201

• Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells.

  Apoptosis : an international journal on programmed cell death 20020201

• Regulation of phospholipase C-gamma 2 via phosphatidylinositol 3-kinase in macrophages.

  Cellular signalling 20020201

• Calorie restriction increases muscle insulin action but not IRS-1-, IRS-2-, or phosphotyrosine-PI 3-kinase.

  American journal of physiology. Endocrinology and metabolism 20020201

• Regulation of K(ATP) channels by P(2Y) purinoceptors coupled to PIP(2) metabolism in guinea pig ventricular cells.

  American journal of physiology. Heart and circulatory physiology 20020201

• Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.

  American journal of physiology. Renal physiology 20020201

• Wortmannin-sensitive pathway is required for insulin-stimulated phosphorylation of inhibitor kappaBalpha.

  Endocrinology 20020201

• Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.

  The Biochemical journal 20020201

• Monocyte survival factors induce Akt activation and suppress caspase-3.

  American journal of respiratory cell and molecular biology 20020201

• Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins.

  Blood 20020201

• Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.

  Diabetes 20020201

• fMLP-induced in vitro nitric oxide production and its regulation in murine peritoneal macrophages.

  Journal of leukocyte biology 20020201

• Activation of the RON receptor tyrosine kinase protects murine macrophages from apoptotic death induced by bacterial lipopolysaccharide.

  Journal of leukocyte biology 20020201

• Phosphatidylinositol 3-kinase inhibitor failed to reduce cerebral vasospasm in dog model of experimental subarachnoid hemorrhage.

  Stroke 20020201

• Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression.

  Hepatology (Baltimore, Md.) 20020201

• Rearrangement of the cytoskeletal network induced by platelet-derived growth factor in rat hepatic stellate cells: role of different intracellular signalling pathways.

  Journal of hepatology 20020201

• Carbon dioxide affects rat colonic Na+ absorption by modulating vesicular traffic.

  Gastroenterology 20020201

• Involvement of Rho and tyrosine kinase in angiotensin II-induced actin reorganization in mesothelial cells.

  European journal of pharmacology 20020201

• Platelet shape changes and adhesion under high shear flow.

  Arteriosclerosis, thrombosis, and vascular biology 20020201

• PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes.

  The Journal of clinical endocrinology and metabolism 20020201

• Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation.

  The American journal of pathology 20020201

• Signal transduction of beta2m-induced expression of VCAM-1 and COX-2 in synovial fibroblasts.

  Kidney international 20020201

• C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway.

  Kidney international 20020201

• Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts.

  European journal of biochemistry 20020201

• Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin.

  Acta pharmacologica Sinica 20020201

• Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2.

  British journal of cancer 20020201

• Signaling pathways activated by chemokine receptor CXCR2 and AMPA-type glutamate receptors and involvement in granule cells survival.

  Journal of neuroimmunology 20020201

• Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling.

  Seminars in immunology 20020201

• IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1.

  Pflugers Archiv : European journal of physiology 20020201

• Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

  The Journal of biological chemistry 20020125

• Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation.

  DNA repair 20020122

• Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells.

  The Journal of biological chemistry 20020118

• Increased activity of c-Src and Csk in fibroblasts transformed by v-src oncogene.

  Biochemical and biophysical research communications 20020118

• Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis.

  Oncogene 20020117

• Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation.

  FEBS letters 20020116

• Alpha 4 integrin signaling activates phosphatidylinositol 3-kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but induces a distinct rearrangement of the actin cytoskeleton.

  Journal of immunology (Baltimore, Md. : 1950) 20020115

• PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

  The EMBO journal 20020115

• Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment.

  The Journal of biological chemistry 20020111

• Phosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110.

  The Journal of biological chemistry 20020111

• Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway.

  The Journal of biological chemistry 20020111

• Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel.

  Current biology : CB 20020108

• A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling.

  The Journal of biological chemistry 20020104

• Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.

  The Journal of biological chemistry 20020104

• Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery.

  European journal of pharmacology 20020102

• P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.

  American journal of physiology. Renal physiology 20020101

• Role of Akt in growth and survival of PANC-1 pancreatic cancer cells.

  Pancreas 20020101

• Agonist-specific differences in mechanisms mediating eNOS-dependent pial arteriolar dilation in rats.

  American journal of physiology. Heart and circulatory physiology 20020101

• Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt.

  American journal of physiology. Heart and circulatory physiology 20020101

• Effect of wortmannin on the suppression of thermotolerance in tsAF8 cells.

  Oncology reports 20020101

• Syntaxin 3 is required for cAMP-induced acid secretion: streptolysin O-permeabilized gastric gland model.

  American journal of physiology. Gastrointestinal and liver physiology 20020101

• The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury.

  American journal of respiratory cell and molecular biology 20020101

• Regulation of the PRL promoter by Akt through cAMP response element binding protein.

  Endocrinology 20020101

• Extracellular signal-regulated kinases and g protein-coupled receptors in megakaryocytic human erythroleukemia cells: selective activation, differential regulation, and dissociation from mitogenesis.

  The Journal of pharmacology and experimental therapeutics 20020101

• NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta.

  European journal of immunology 20020101

• Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3).

  Blood 20020101

• Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals.

  Diabetes 20020101

• Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway.

  Diabetes 20020101

• Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.

  European journal of biochemistry 20020101

• Roles of the N- and C-termini of GLUT4 in endocytosis.

  Journal of cell science 20020101

• Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL.

  Journal of cellular physiology 20020101

• Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.

  Arthritis and rheumatism 20020101

• Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin.

  The Plant cell 20020101

• Insulin-like growth factor-1 protects peroxynitrite-induced cell death by preventing cytochrome c-induced caspase-3 activation.

  Journal of cellular biochemistry 20020101

• Hyaluronic acid and chondroitin sulphate A rapidly promote differentiation of immature DC with upregulation of costimulatory and antigen-presenting molecules, and enhancement of NF-kappaB and protein kinase activity.

  Scandinavian journal of immunology 20020101

• Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli.

  Cellular microbiology 20020101

• The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells.

  Cellular microbiology 20020101

• Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.

  Arthritis research 20020101

• Chemiluminescent detection of induced reactive oxygen metabolite production of human polymorphonuclear leucocytes by anthophyllite asbestos.

  Environmental research 20020101

• Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.

  Journal of neurochemistry 20020101

• Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53.

  BMC biotechnology 20020101

• Vanadate protects human neuroblastoma SH-SY5Y cells against peroxynitrite-induced cell death.

  Journal of cellular biochemistry 20020101

• The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes.

  BMC biochemistry 20020101

• Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway.

  Oncology reports 20020101

• [Phosphorylation and dephosphorylation of rna polymerase III holoenzyme are modifications regulating the level of transcription in vitro].

  Tsitologiia 20020101

• Recombinant human platelet-derived growth factor and transforming growth factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require phosphatidylinositol-3' kinase.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20020101

• Implications of phosphoinositide 3-kinase in the mu- and delta-opioid receptor-mediated supraspinal antinociception in the mouse.

  Neuroscience 20020101

• DNA-PK inhibitor wortmannin enhances DNA damage induced by bleomycin in V79 Chinese hamster cells.

  Teratogenesis, carcinogenesis, and mutagenesis 20020101

• Involvement of PI3-kinase and its association with c-Src in PTH-stimulated rat enterocytes.

  Journal of cellular biochemistry 20020101

• Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3'-kinase-mediates PKC delta phosphorylation: role of PKC in angiogenesis.

  Cell biology international 20020101

• Activation of peroxisome proliferator-activated receptor-gamma inhibits apoptosis induced by serum deprivation in LLC-PK1 cells.

  Experimental nephrology 20020101

• Bacterial killing by Mytilus hemocyte monolayers as a model for investigating the signaling pathways involved in mussel immune defence.

  Marine environmental research 20020101

• Activation of the glucose transporter GLUT4 by insulin.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20020101

• The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils.

  Cellular immunology 20020101

• Possible involvement of C-C chemokines in functional augmentation of adhesion molecules in asthmatic patients.

  Lung 20020101

• Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells.

  Respiratory research 20020101

• TRAIL-DISC formation is androgen-dependent in the human prostatic carcinoma cell line LNCaP.

  Cancer biology & therapy 20020101

• Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells.

  Cell communication & adhesion 20020101

• The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells.

  Experimental & molecular medicine 20011231

• Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway.

  The Journal of biological chemistry 20011228

• Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes.

  The Journal of biological chemistry 20011228

• 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells.

  The Journal of biological chemistry 20011228

• Effects of wortmannin on airways inflammation induced by allergen in actively sensitised Brown Norway rats.

  European journal of pharmacology 20011221

• A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA.

  Blood 20011215

• Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1).

  Blood 20011215

• Regulation and possible function of beta-catenin in human monocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20011215

• CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell alpha chemoattractant (CXCL11).

  Journal of immunology (Baltimore, Md. : 1950) 20011215

• Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.

  Archives of biochemistry and biophysics 20011215

• Intercellular exchange of class II major histocompatibility complex/peptide complexes is a conserved process that requires activation of T cells but is constitutive in other types of antigen presenting cell.

  Cellular immunology 20011215

• Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells. Implications for inflammatory diarrheal states.

  The Journal of biological chemistry 20011214

• Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation.

  European journal of pharmacology 20011214

• Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin.

  Experimental cell research 20011210

• Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport.

  The Journal of biological chemistry 20011207

• Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling.

  Circulation research 20011207

• Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.

  Oncogene 20011206

• Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development.

  Oncogene 20011206

• Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells.

  American journal of physiology. Cell physiology 20011201

• Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line.

  American journal of physiology. Cell physiology 20011201

• Half-lives of plasma membrane Na(+)/H(+) exchangers NHE1-3: plasma membrane NHE2 has a rapid rate of degradation.

  American journal of physiology. Cell physiology 20011201

• Synthesis and biological evaluation of L-alpha-phosphatidyl-D-3-deoxy-3-heteromethyl-myo-inositols as phosphoinositide 3-kinase inhibitors.

  Bioorganic & medicinal chemistry 20011201

• LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells.

  Endocrinology 20011201

• Regulation of nitric oxide production by murine peritoneal macrophages treated in vitro with chemokine monocyte chemoattractant protein 1.

  Nitric oxide : biology and chemistry 20011201

• Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.

  Cancer research 20011201

• Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.

  Carcinogenesis 20011201

• Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase.

  Hypertension (Dallas, Tex. : 1979) 20011201

• Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester.

  Platelets 20011201

• Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors.

  British journal of haematology 20011201

• Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells.

  The Journal of biological chemistry 20011130

• Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter.

  The Journal of biological chemistry 20011130

• The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase.

  The Journal of biological chemistry 20011130

• Regulation of vascular endothelial growth factor expression by advanced glycation end products.

  The Journal of biological chemistry 20011123

• Three distinct lipid kinase activities are present in spinach chloroplast envelope membranes: phosphatidylinositol phosphorylation is sensitive to wortmannin and not dependent on chloroplast ATP.

  Biochemical and biophysical research communications 20011123

• CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.

  Cytokine 20011121

• Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor.

  The Biochemical journal 20011115

• Increase in hepatocyte growth factor receptor tyrosine kinase activity in renal carcinoma cells is associated with increased motility partly through phosphoinositide 3-kinase activation.

  Oncogene 20011115

• Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4.

  The Journal of biological chemistry 20011109

• Endofin, an endosomal FYVE domain protein.

  The Journal of biological chemistry 20011109

• Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions.

  The Journal of biological chemistry 20011109

• ATM phosphorylates histone H2AX in response to DNA double-strand breaks.

  The Journal of biological chemistry 20011109

• Vascular smooth muscle cell spreading onto fibrinogen is regulated by calpains and phospholipase C.

  Biochemical and biophysical research communications 20011109

• ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth.

  Oncogene 20011108

• Chemoattractant-stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA.

  The Journal of biological chemistry 20011102

• Mammalian TOR: a homeostatic ATP sensor.

  Science (New York, N.Y.) 20011102

• Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5.

  The international journal of biochemistry & cell biology 20011101

• ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species.

  American journal of physiology. Lung cellular and molecular physiology 20011101

• TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome.

  Mutation research 20011101

• Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.

  The Journal of pharmacology and experimental therapeutics 20011101

• Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

• Platelet-conditioned medium increases endothelial electrical resistance independently of cAMP/PKA and cGMP/PKG.

  American journal of physiology. Heart and circulatory physiology 20011101

• Effect of short-term cyclic stretch on sodium pump activity in aortic smooth muscle cells.

  American journal of physiology. Heart and circulatory physiology 20011101

• PtdIns(4,5)P(2) and phospholipase C-independent Ins(1,4,5)P(3) signals induced by a nitrogen source in nitrogen-starved yeast cells.

  The Biochemical journal 20011101

• Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils.

  Archives of biochemistry and biophysics 20011101

• Role of phosphoinositide 3-kinase in adhesion of platelets to fibrinogen stimulated by cancer procoagulant.

  Platelets 20011101

• The AKT kinase is activated in multiple myeloma tumor cells.

  Blood 20011101

• Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of only alpha1A-adrenoceptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20011101

• Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.

  The Journal of clinical investigation 20011101

• Regulation of the very late antigen-4-mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and phosphatidylinositol 3-kinase.

  Journal of leukocyte biology 20011101

• Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011101

• Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells.

  Kidney international 20011101

• Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.

  British journal of pharmacology 20011101

• Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells.

  Oncogene 20011101

• Dual signaling via protein kinase C and phosphatidylinositol 3'-kinase/Akt contributes to bradykinin B2 receptor-induced cardioprotection in guinea pig hearts.

  Journal of molecular and cellular cardiology 20011101

• Differential role of kinases in brain stem of hypertensive and normotensive rats.

  Hypertension (Dallas, Tex. : 1979) 20011101

• Effect of wortmannin on human eosinophil responses in vitro and on bronchial inflammation and airway hyperresponsiveness in Guinea pigs in vivo.

  American journal of respiratory and critical care medicine 20011101

• Insulin-like growth factor-1 improves postischemic recovery in hypertrophied hearts.

  The Annals of thoracic surgery 20011101

• Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.

  Genes to cells : devoted to molecular & cellular mechanisms 20011101

• FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.

  Journal of cell science 20011101

• The role of phosphoinositide 3-kinase in the sorting and transport of newly synthesized tyrosinase-related protein-1 (TRP-1).

  The journal of investigative dermatology. Symposium proceedings 20011101

• Evidence for distinct membrane traffic pathways to melanosomes and lysosomes in melanocytes.

  The journal of investigative dermatology. Symposium proceedings 20011101

• Arsenite activation of P13K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes.

  Molecular medicine (Cambridge, Mass.) 20011101

• Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide.

  The Journal of biological chemistry 20011026

• Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore.

  Life sciences 20011026

• Induction of interleukin-1beta and interleukin-6 mRNA by low doses of ionizing radiation in macrophages.

  International journal of cancer 20011020

• Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance.

  The Journal of biological chemistry 20011019

• Angiotensin II-induced transcriptional activation of the cyclin D1 gene is mediated by Egr-1 in CHO-AT(1A) cells.

  The Journal of biological chemistry 20011019

• Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538.

  Biochemical and biophysical research communications 20011019

• Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells.

  Biochemical and biophysical research communications 20011019

• A PtdIns(3)P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells.

  Current biology : CB 20011016

• Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.

  Toxicology 20011015

• IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase.

  Journal of immunology (Baltimore, Md. : 1950) 20011015

• Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase.

  The EMBO journal 20011015

• E1A inhibition of radiation-induced NF-kappaB activity through suppression of IKK activity and IkappaB degradation, independent of Akt activation.

  Cancer research 20011015

• Nuclear retention of ATM at sites of DNA double strand breaks.

  The Journal of biological chemistry 20011012

• Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.

  The Journal of biological chemistry 20011012

• The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes.

  The Journal of biological chemistry 20011005

• Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism.

  Biochemistry 20011002

• Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.

  American journal of physiology. Cell physiology 20011001

• Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.

  Molecular pharmacology 20011001

• Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308.

  The Biochemical journal 20011001

• Prostaglandin E(2) (EP(1)) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-alpha.

  Endocrinology 20011001

• Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress.

  Journal of applied physiology (Bethesda, Md. : 1985) 20011001

• Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway.

  Diabetes 20011001

• Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.

  Diabetes 20011001

• Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.

  Molecular endocrinology (Baltimore, Md.) 20011001

• Phosphoinositide 3-kinase inhibits megalin-mediated transcytosis of thyroglobulin across thyroid epithelial cells at a post-sorting level.

  European journal of endocrinology 20011001

• In vivo intracellular signaling as a marker of antiangiogenic activity.

  Cancer research 20011001

• Antimitogenic and proapoptotic activities of methylseleninic acid in vascular endothelial cells and associated effects on PI3K-AKT, ERK, JNK and p38 MAPK signaling.

  Cancer research 20011001

• Reduction of oxidative stress and AT1 receptor expression by the selective oestrogen receptor modulator idoxifene.

  British journal of pharmacology 20011001

• Phosphatidylinositol 3-kinase and ERK are required for NF-kappaB activation but not for phagocytosis.

  Journal of leukocyte biology 20011001

• Antiapoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after gamma-irradiation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

• Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

• Phosphatidylinositol 3-OH kinase-Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell line.

  Arteriosclerosis, thrombosis, and vascular biology 20011001

• Maitotoxin-induced calcium entry in human lymphocytes: modulation by yessotoxin, Ca(2+) channel blockers and kinases.

  Cellular signalling 20011001

• Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.

  British journal of pharmacology 20011001

• Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011001

• Molecular basis for the insulinomimetic effects of C-peptide.

  Diabetologia 20011001

• The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC.

  Journal of cell science 20011001

• A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation.

  Journal of cell science 20011001

• Secretion of gelatinases and activation of gelatinase A (MMP-2) by human rheumatoid synovial fibroblasts.

  Biological chemistry 20011001

• Ras/MAP kinase pathway is associated with the control of myotube formation but not myofibril assembly in quail myoblasts transformed with Rous sarcoma virus.

  Cell structure and function 20011001

• Signaling mechanism for equine neutrophil activation by immune complexes.

  Veterinary immunology and immunopathology 20010928

• 1alpha,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase.

  The Journal of biological chemistry 20010921

• Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.

  The Journal of biological chemistry 20010921

• Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.

  The Journal of biological chemistry 20010921

• Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides.

  FEBS letters 20010921

• Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.

  Oncogene 20010920

• IL-3 induces down-regulation of CCR3 protein and mRNA in human eosinophils.

  Journal of immunology (Baltimore, Md. : 1950) 20010915

• Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase.

  EMBO reports 20010915

• Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.

  The Journal of biological chemistry 20010914

• Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats.

  Circulation research 20010914

• The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism.

  FEBS letters 20010914

• A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala.

  Neuron 20010913

• An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression.

  The Journal of biological chemistry 20010907

• Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells.

  The Journal of biological chemistry 20010907

• Hrs recruits clathrin to early endosomes.

  The EMBO journal 20010903

• Induction of osteoblast differentiation indexes by PTHrP in MG-63 cells involves multiple signaling pathways.

  American journal of physiology. Endocrinology and metabolism 20010901

• E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway.

  Endocrinology 20010901

• GH regulation of IGF-I and suppressor of cytokine signaling gene expression in C2C12 skeletal muscle cells.

  Endocrinology 20010901

• Dissociation between insulin-mediated signaling pathways and biological effects in placental cells: role of protein kinase B and MAPK phosphorylation.

  Endocrinology 20010901

• Oxidized low density lipoprotein inhibits macrophage apoptosis through activation of the PI 3-kinase/PKB pathway.

  Journal of lipid research 20010901

• Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation.

  Blood 20010901

• The effect of 24R,25-(OH)(2)D(3) on protein kinase C activity in chondrocytes is mediated by phospholipase D whereas the effect of 1alpha,25-(OH)(2)D(3) is mediated by phospholipase C.

  Steroids 20010901

• Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation.

  The Journal of clinical endocrinology and metabolism 20010901

• Troglitazone enhances glucose uptake induced by alpha-adrenoceptor stimulation via phosphatidylinositol 3-kinase in rat heart.

  Clinical and experimental pharmacology & physiology 20010901

• Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells.

  Journal of neurochemistry 20010901

• The relationship between lumenal and limiting membranes in swollen late endocytic compartments formed after wortmannin treatment or sucrose accumulation.

  Traffic (Copenhagen, Denmark) 20010901

• Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas.

  Journal of neurosurgery 20010901

• Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.

  Endocrine-related cancer 20010901

• Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry.

  The European journal of neuroscience 20010901

• Insulin in combination with vanadate stimulates glucose transport in isolated cardiomyocytes from obese Zucker rats.

  Cardiovascular drugs and therapy 20010901

• Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway.

  The Journal of biological chemistry 20010831

• Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway.

  The Journal of biological chemistry 20010831

• Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

  The Journal of biological chemistry 20010831

• Inhibition of protein tyrosine phosphatases suppresses P-selectin exocytosis in activated human platelets.

  Biochemical and biophysical research communications 20010831

• Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway.

  The Journal of biological chemistry 20010824

• Gas6 anti-apoptotic signaling requires NF-kappa B activation.

  The Journal of biological chemistry 20010824

• Phosphatidylinositol 3-kinase-dependent extracellular calcium influx is essential for CX(3)CR1-mediated activation of the mitogen-activated protein kinase cascade.

  The Journal of biological chemistry 20010824

• Inhibition of protein tyrosine phosphatases suppresses P-selectin exocytosis in activated human platelets.

  Biochemical and biophysical research communications 20010824

• Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: protection by estrogen and glutathione.

  FEBS letters 20010824

• Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the phosphatidylinositol 3-kinase and STAT3 pathways.

  Neuroscience letters 20010817

• Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase.

  Journal of immunology (Baltimore, Md. : 1950) 20010815

• Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

  Cancer research 20010815

• Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia.

  Cancer research 20010815

• Akt is activated in response to an apoptotic signal.

  The Journal of biological chemistry 20010810

• A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.

  The Journal of biological chemistry 20010810

• Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS.

  Neuroreport 20010808

• Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways.

  The Journal of biological chemistry 20010803

• Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.

  The Journal of biological chemistry 20010803

• p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils.

  FEBS letters 20010803

• beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells.

  Journal of cellular physiology 20010801

• Role of protein kinase Cdelta in transmitting hypoxia signal to HSF and HIF-1.

  Journal of cellular physiology 20010801

• Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle.

  American journal of physiology. Cell physiology 20010801

• Inhibition of TASK-1 potassium channel by phospholipase C.

  American journal of physiology. Cell physiology 20010801

• PI 3-kinases and Src kinases regulate spreading and migration of cultured VSMCs.

  American journal of physiology. Cell physiology 20010801

• HGF- and KGF-induced activation of PI-3K/p70 s6 kinase pathway in corneal epithelial cells: its relevance in wound healing.

  Experimental eye research 20010801

• Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons.

  Endocrinology 20010801

• MIP-1alpha induces activation of phosphatidylinositol-3 kinase that associates with Pyk-2 and is necessary for B-cell migration.

  Experimental cell research 20010801

• Polyamine- and insulin-like growth factor-I-mediated proliferation of porcine uterine endometrial cells: a potential role for spermidine/spermine N(1)-acetyltransferase during peri-implantation.

  Biology of reproduction 20010801

• Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells.

  Kidney international 20010801

• The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3.

  Journal of neurochemistry 20010801

• Regulation of functional nitric oxide synthase-1 expression in cerebellar granule neurons by heregulin is post-transcriptional, and involves mitogen-activated protein kinase.

  Journal of neurochemistry 20010801

• Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1.

  Diabetologia 20010801

• Binding of the non-typeable Haemophilus influenzae lipooligosaccharide to the PAF receptor initiates host cell signalling.

  Cellular microbiology 20010801

• Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.

  European journal of biochemistry 20010801

• Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.

  European journal of biochemistry 20010801

• Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor-alpha/cycloheximide-induced apoptosis by regulating protein kinase B levels.

  European journal of biochemistry 20010801

• A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes.

  Journal of the American College of Nutrition 20010801

• Evidence for two mechanisms of amino acid osmolyte release from hippocampal slices.

  Pflugers Archiv : European journal of physiology 20010801

• Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2') by the lipid kinase inhibitor wortmannin.

  Chemistry & biology 20010801

• Distinct involvement of NF-kappaB and p38 mitogen-activated protein kinase pathways in serum deprivation-mediated stimulation of inducible nitric oxide synthase and its inhibition by 4-hydroxynonenal.

  Journal of cellular biochemistry 20010801

• Phosphatidylinositol 3-kinase regulates proliferation of RAW 264.7 macrophages.

  Immunopharmacology and immunotoxicology 20010801

• The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways.

  The Journal of biological chemistry 20010727

• The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.

  The Journal of biological chemistry 20010727

• Role of PI3-kinase in isoproterenol and IGF-1 induced ecNOS activity.

  Biochemical and biophysical research communications 20010727

• Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions.

  The Journal of biological chemistry 20010720

• Insulin stimulates membrane conductance in a liver cell line: evidence for insertion of ion channels through a phosphoinositide 3-kinase-dependent mechanism.

  The Journal of biological chemistry 20010720

• The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line.

  International journal of radiation oncology, biology, physics 20010715

• Wortmannin-sensitive trafficking steps in the endocytic pathway in rat liver endothelial cells.

  The Biochemical journal 20010715

• Androgen blocks apoptosis of hormone-dependent prostate cancer cells.

  Cancer research 20010715

• The generation of superoxide anion in blood platelets in response to different forms of Proteus mirabilis lipopolysaccharide: effects of staurosporin, wortmannin, and indomethacin.

  Thrombosis research 20010715

• Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and Fc gamma IIA receptor.

  The Journal of biological chemistry 20010713

• Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35).

  Brain research 20010713

• Production of proinflammatory cytokines by resident tissue macrophages after phagocytosis of apoptotic cells.

  Cellular immunology 20010710

• The v-Crk oncogene enhances cell survival and induces activation of protein kinase B/Akt.

  The Journal of biological chemistry 20010706

• Inhibition of Na,K-ATPase activates PI3 kinase and inhibits apoptosis in LLC-PK1 cells.

  Biochemical and biophysical research communications 20010706

• Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).

  Circulation research 20010706

• Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• Selective insulin-induced activation of class I(A) phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes.

  Molecular and cellular endocrinology 20010705

• Phosphatidylinositol 3-kinase-dependent stabilization of alpha1(I) collagen mRNA in human lung fibroblasts.

  American journal of physiology. Cell physiology 20010701

• Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells.

  American journal of physiology. Gastrointestinal and liver physiology 20010701

• Dopamine D(4) and D(2L) Receptor Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Dependent on trans-Activation of the Platelet-Derived Growth Factor Receptor.

  Molecular pharmacology 20010701

• Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways.

  Endocrinology 20010701

• Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release.

  Journal of immunology (Baltimore, Md. : 1950) 20010701

• Intracellular signals triggered during association of Mycobacterium leprae and Mycobacterium bovis BCG with human monocytes.

  Microbial pathogenesis 20010701

• Modulation of adenosine transport by insulin in human umbilical artery smooth muscle cells from normal or gestational diabetic pregnancies.

  The Journal of physiology 20010701

• SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.

  Nature cell biology 20010701

• Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.

  Molecular endocrinology (Baltimore, Md.) 20010701

• TGF-alpha inhibits apoptosis of murine gastric pit cells through an NF-kappaB-dependent pathway.

  Gastroenterology 20010701

• Phosphatidyl-inositol-3 kinase-independent insulin action pathway(s) in the human ovary.

  The Journal of clinical endocrinology and metabolism 20010701

• Transforming growth factor-beta induces osteoclast ruffling and chemotaxis: potential role in osteoclast recruitment.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010701

• Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin.

  Arteriosclerosis, thrombosis, and vascular biology 20010701

• Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20010701

• Wortmannin inhibits platelet aggregation produced by interaction of gamma-aminobutyric acid and the calcium tonophore, A23187.

  Research communications in molecular pathology and pharmacology 20010701

• Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.

  Arthritis and rheumatism 20010701

• Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction.

  Molecular carcinogenesis 20010701

• The effects of insulin and beta-adrenergic stimulation on glucose transport, glut 4 and PKB activation in the myocardium of lean and obese non-insulin dependent diabetes mellitus rats.

  Molecular and cellular biochemistry 20010701

• Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity.

  The Journal of biological chemistry 20010629

• Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.

  The Journal of biological chemistry 20010622

• Hyperosmolarity reduces GLUT4 endocytosis and increases its exocytosis from a VAMP2-independent pool in l6 muscle cells.

  The Journal of biological chemistry 20010622

• Resting (basal) secretion of proteins is provided by the minor regulated and constitutive-like pathways and not granule exocytosis in parotid acinar cells.

  The Journal of biological chemistry 20010622

• Characterization of a G protein-activated phosphoinositide 3-kinase in vascular smooth muscle cell nuclei.

  The Journal of biological chemistry 20010622

• Phosphatidylinositol 4,5-bisphosphate mediates Ca2+-induced platelet alpha-granule secretion: evidence for type II phosphatidylinositol 5-phosphate 4-kinase function.

  The Journal of biological chemistry 20010622

• Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.

  The Journal of biological chemistry 20010622

• IL-6 upregulates its own receptor on some human myeloma cell lines.

  Cytokine 20010621

• Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

  The Journal of biological chemistry 20010615

• Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

  The Journal of biological chemistry 20010615

• Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils.

  Journal of immunology (Baltimore, Md. : 1950) 20010615

• Activation of phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells.

  Neuroreport 20010613

• Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells.

  The Journal of biological chemistry 20010608

• Phospholipase C-gamma mediates the hydrolysis of phosphatidylinositol, but not of phosphatidylinositol 4,5-bisphoshate, in carbamylcholine-stimulated islets of langerhans.

  The Journal of biological chemistry 20010601

• Cell cycle-dependent effects of wortmannin on radiation survival and mutation.

  Radiation research 20010601

• Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin.

  Endocrinology 20010601

• Involvement of oxidative stress in ascorbate-induced proapoptotic death of PC12 cells.

  Experimental neurology 20010601

• LFA-1-mediated costimulation of CD8+ T cell proliferation requires phosphatidylinositol 3-kinase activity.

  Journal of immunology (Baltimore, Md. : 1950) 20010601

• Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines.

  Journal of immunology (Baltimore, Md. : 1950) 20010601

• Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.

  Journal of immunology (Baltimore, Md. : 1950) 20010601

• Role for phosphatidylinositol in nuclear envelope formation.

  The Biochemical journal 20010601

• Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells.

  International immunology 20010601

• The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

  Diabetes 20010601

• The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes.

  Gastroenterology 20010601

• Upregulation of phospholipase Cgamma1 activity during EGF-induced proliferation of corneal epithelial cells: effect of phosphoinositide-3 kinase.

  Investigative ophthalmology & visual science 20010601

• Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.

  Nature medicine 20010601

• NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46.

  European journal of immunology 20010601

• Odor-stimulated phosphatidylinositol 3-kinase in lobster olfactory receptor cells.

  Journal of neurophysiology 20010601

• Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system.

  Cancer research 20010601

• Stromal cell-derived factor-1alpha induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway.

  Journal of neurochemistry 20010601

• Evidence for the involvement of phosphatidylinositol 3-kinase in fMLP-stimulated neutrophil adhesion to ICAM-1-transfected cells.

  Journal of cardiovascular pharmacology 20010601

• In vitro hormone induction of final oocyte maturation in striped bass (Morone saxatilis) follicles is inhibited by blockers of phosphatidylinositol 3-kinase activity.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010601

• Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010601

• Platelet collagen receptor integrin alpha2beta1 activation involves differential participation of ADP-receptor subtypes P2Y1 and P2Y12 but not intracellular calcium change.

  European journal of biochemistry 20010601

• Initiation of cell locomotility is a morphogenetic checkpoint in thyroid epithelial cells regulated by ERK and PI3-kinase signals.

  Cell motility and the cytoskeleton 20010601

• Protein kinase C and phosphatidylinositol 3-kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule.

  Pflugers Archiv : European journal of physiology 20010601

• Effects of phosphatidylinositol kinase inhibitors on the activation of the store-operated calcium current ICRAC in RBL-1 cells.

  Pflugers Archiv : European journal of physiology 20010601

• Modulation of retinal endothelial cell behaviour by insulin-like growth factor I and somatostatin analogues: implications for diabetic retinopathy.

  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20010601

• Leptin stimulates rat aortic smooth muscle cell proliferation and migration.

  The Kobe journal of medical sciences 20010601

• Phosphoinositide 3-kinase inhibition in cancer treatment.

  Expert opinion on investigational drugs 20010601

• Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells.

  Biochimica et biophysica acta 20010528

• Presence and activation of nuclear phosphoinositide 3-kinase C2beta during compensatory liver growth.

  The Journal of biological chemistry 20010525

• Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation.

  The Journal of biological chemistry 20010525

• Activation of phosphatidylinositol 3-kinase by oxidative stress leads to the induction of microsomal epoxide hydrolase in H4IIE cells.

  Toxicology letters 20010519

• The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade.

  The Journal of biological chemistry 20010518

• Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.

  European journal of pharmacology 20010518

• Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways.

  International journal of cancer 20010515

• A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebrates.

  Biochemical pharmacology 20010515

• Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins.

  Experimental cell research 20010515

• Phosphoinositide 3-kinase modulation of beta(3)-integrin represents an endogenous 'braking' mechanism during neutrophil transmatrix migration.

  Blood 20010515

• Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils.

  Journal of immunology (Baltimore, Md. : 1950) 20010515

• Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

  Cancer research 20010515

• Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry.

  The Journal of biological chemistry 20010511

• Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation.

  The Journal of biological chemistry 20010511

• Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling.

  Circulation research 20010511

• Insulin-like growth factor I potentiates kainate receptors through a phosphatidylinositol 3-kinase dependent pathway.

  Neuroreport 20010508

• Gastrin-induced DNA synthesis requires p38-MAPK activation via PKC/Ca(2+) and Src-dependent mechanisms.

  FEBS letters 20010504

• Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax.

  Oncogene 20010503

• P2Y(2) nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases.

  Journal of cellular physiology 20010501

• Importance of PKC and PI3Ks in ethanol-induced contraction of cerebral arterial smooth muscle.

  American journal of physiology. Heart and circulatory physiology 20010501

• PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes.

  Molecular pharmacology 20010501

• Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells.

  Molecular pharmacology 20010501

• Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation.

  Gastroenterology 20010501

• Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites.

  Journal of cell science 20010501

• Troglitazone induces GLUT4 translocation in L6 myotubes.

  Diabetes 20010501

• Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes.

  The Journal of nutrition 20010501

• Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells.

  Hepatology (Baltimore, Md.) 20010501

• Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway.

  British journal of cancer 20010501

• Phosphatidylinositol 3-kinase inhibitors prevent mouse cytotoxic T-cell development in vitro.

  Journal of leukocyte biology 20010501

• Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.

  Cellular signalling 20010501

• Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation.

  Cellular signalling 20010501

• Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function.

  Experimental hematology 20010501

• Signal transduction via both human low-affinity IgG Fc receptors, Fc gamma RIIa and Fc gamma RIIIb, depends on the activity of different families of intracellular kinases.

  Immunobiology 20010501

• Inhibition of encystation of Entamoeba invadens by wortmannin.

  Parasitology research 20010501

• Regulation of MUC1 expression in human mammary cell lines by the c-ErbB2 and ras signaling pathways.

  DNA and cell biology 20010501

• Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20010501

• Differential effect of PKC isoform on insulin- and phorbol ester-stimulated glucose uptake mechanism in rat adipocytes.

  IUBMB life 20010501

• Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages.

  Glycoconjugate journal 20010501

• Increased extracellular magnesium modulates proliferation in fetal neural cells in culture.

  Brain research. Developmental brain research 20010430

• Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.

  The Journal of biological chemistry 20010427

• alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity.

  The Journal of biological chemistry 20010427

• Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells.

  The Journal of biological chemistry 20010427

• Fibroblast growth factors 1 and 2 differently activate MAP kinase in Xenopus oocytes expressing fibroblast growth factor receptors 1 and 4.

  Biochimica et biophysica acta 20010423

• Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.

  The Journal of biological chemistry 20010420

• Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.

  The Journal of biological chemistry 20010420

• Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells.

  Biochemical and biophysical research communications 20010420

• Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.

  Brain research. Molecular brain research 20010418

• Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network.

  EMBO reports 20010415

• Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells.

  The Journal of biological chemistry 20010413

• Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis.

  The Journal of biological chemistry 20010406

• Pleiotrophin induces angiogenesis: involvement of the phosphoinositide-3 kinase but not the nitric oxide synthase pathways.

  Journal of cellular physiology 20010401

• Mechanism by which wortmannin and LY294002 inhibit catecholamine secretion in the rat adrenal medullary cells.

  Cell calcium 20010401

• Insulin increases the turnover rate of Na+-K+-ATPase in human fibroblasts.

  American journal of physiology. Cell physiology 20010401

• Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin.

  Journal of immunology (Baltimore, Md. : 1950) 20010401

• Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein.

  The Biochemical journal 20010401

• p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium.

  Journal of cell science 20010401

• Trypanosoma cruzi: phosphatidylinositol 3-kinase and protein kinase B activation is associated with parasite invasion.

  Experimental cell research 20010401

• Intracellular Angiotensin II and cell growth of vascular smooth muscle cells.

  British journal of pharmacology 20010401

• Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells.

  Gastroenterology 20010401

• Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway.

  Molecular endocrinology (Baltimore, Md.) 20010401

• The role of phosphoinositide 3-kinase in spreading osteoclasts induced by colony-stimulating factor-1.

  European journal of endocrinology 20010401

• Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.

  European journal of biochemistry 20010401

• The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells.

  International journal of cancer 20010401

• Pharmacology of phosphoinositides, regulators of multiple cellular functions.

  Current pharmaceutical design 20010401

• Phosphatidylinositol 3-kinase mediates integrin-dependent NF-kappaB and MAPK activation through separate signaling pathways.

  Journal of cell science 20010401

• The neuron-glia signal beta-neuregulin promotes Schwann cell motility via the MAPK pathway.

  Glia 20010401

• Regulation of translation initiation by FRAP/mTOR.

  Genes & development 20010401

• Myosin light chain kinase regulates capacitative ca(2+) entry in human monocytes/macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20010401

• Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.

  Cellular signalling 20010401

• Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.

  Journal of leukocyte biology 20010401

• MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner.

  Journal of leukocyte biology 20010401

• Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.

  Inflammation 20010401

• Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401

• Integrating signals from T-cell receptor and serum by T cells enhance translation of tumour necrosis factor-alpha.

  Immunology 20010401

• Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling.

  Thyroid : official journal of the American Thyroid Association 20010401

• IL-5 priming of the PMA-induced oxidative metabolism of human eosinophils from allergic and normal subjects during a pollen season.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010401

• Grb-2-associated binder-1 is involved in insulin-induced egr-1 gene expression through its phosphatidylinositol 3'-kinase binding site.

  DNA and cell biology 20010401

• Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes.

  The Journal of biological chemistry 20010330

• Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.

  Circulation research 20010330

• Insulin activates phospholipase C-gamma1 via a PI-3 kinase dependent mechanism in 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20010330

• The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells.

  Journal of cellular biochemistry 20010326

• Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin.

  The Journal of biological chemistry 20010323

• ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.

  The Journal of biological chemistry 20010323

• Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts.

  The Journal of biological chemistry 20010323

• A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

  The Journal of biological chemistry 20010323

• Oxidative stress induced by ascorbate causes neuronal damage in an in vitro system.

  Brain research 20010323

• A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans.

  The Journal of biological chemistry 20010316

• PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.

  Human molecular genetics 20010315

• A low-pH culture condition enhances the radiosensitizing effect of wortmannin.

  International journal of radiation oncology, biology, physics 20010315

• Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010315

• The Rho/Rho-kinase and the phosphatidylinositol 3-kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells.

  International journal of cancer 20010315

• Opposite regulation of the HPV 20-URR and HPV 27-URR promoters by ultraviolet irradiation and cytokines.

  International journal of cancer 20010315

• Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation.

  Cancer research 20010315

• The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B.

  Cancer research 20010315

• Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

  Oncogene 20010315

• Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.

  The Journal of biological chemistry 20010309

• ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.

  The Journal of biological chemistry 20010309

• TNFalpha elicits association of PI 3-kinase with the p60TNFR and activation of PI 3-kinase in adherent neutrophils.

  Biochemical and biophysical research communications 20010302

• Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.

  Biochemical and biophysical research communications 20010302

• Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase.

  FEBS letters 20010302

• Angiotensin AT(1) receptor phosphorylation and desensitization in a hepatic cell line. Roles of protein kinase c and phosphoinositide 3-kinase.

  Molecular pharmacology 20010301

• Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.

  International journal of molecular medicine 20010301

• Involvement of both phosphatidylinositol 3-kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin.

  Endocrinology 20010301

• Activation of phosphatidylinositol-3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010301

• Roles of phosphatidylinositol 3-kinase and phospholipase D in temporal activation of superoxide production in FMLP-stimulated human neutrophils.

  Cell biochemistry and function 20010301

• Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes.

  Hepatology (Baltimore, Md.) 20010301

• Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.

  European journal of biochemistry 20010301

• Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells.

  Kidney international 20010301

• Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration.

  Nature cell biology 20010301

• Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis.

  Journal of neurochemistry 20010301

• Human rad21 gene, hHR21(SP), is downregulated by hypoxia in human tumor cells.

  Biochemical and biophysical research communications 20010301

• Biosynthesis and processing of cathepsin K in cultured human osteoclasts.

  Bone 20010301

• Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator.

  British journal of haematology 20010301

• Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis.

  Cancer research 20010301

• Molecular mechanisms for alpha2-adrenoceptor-mediated regulation of synoviocyte populations.

  Japanese journal of pharmacology 20010301

• Involvement of the glycoproteic Ib-V-IX complex in nickel-induced platelet activation.

  Environmental health perspectives 20010301

• Effects of staurosporine, U-73122, wortmannin, 4-hydroxynonenal and sodium azide upon the release of secreted beta-amyloid precursor protein from human platelets in response to thrombin stimulation.

  Molecular and cellular biochemistry 20010301

• [A study of different intracellular signal transduction pathways on phagocytosis of fibronectin by retinal pigment epithelial cells].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20010301

• Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.

  The Journal of biological chemistry 20010216

• The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.

  The Journal of biological chemistry 20010216

• Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells.

  European journal of pharmacology 20010216

• Comparison of macrophage responses to oxidized low-density lipoprotein and macrophage colony-stimulating factor (M-CSF or CSF-1).

  The Biochemical journal 20010215

• Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration.

  Cancer research 20010215

• Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.

  Archives of biochemistry and biophysics 20010215

• Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN.

  Archives of biochemistry and biophysics 20010215

• Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells.

  European journal of pharmacology 20010209

• Effects of wortmannin upon the late stages of the secretory pathway of AtT-20 cells.

  European journal of pharmacology 20010209

• The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6.

  Oncogene 20010208

• Activation of extracellular-regulated kinases by normal and mutant EGF receptors.

  Biochimica et biophysica acta 20010205

• Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells.

  The Journal of biological chemistry 20010202

• Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.

  Biochemical and biophysical research communications 20010202

• CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1.

  FEBS letters 20010202

• Influence of protein kinases on the osmosensitive release of taurine from cerebellar granule neurons.

  Neurochemistry international 20010201

• HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201

• Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation.

  Blood 20010201

• Involvement of both G protein alphas and beta gamma subunits in beta-adrenergic stimulation of vascular L-type Ca(2+) channels.

  British journal of pharmacology 20010201

• Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells.

  Journal of immunology (Baltimore, Md. : 1950) 20010201

• The endosomal trafficking of apolipoprotein E3 and E4 in cultured human brain neurons and astrocytes.

  Neurobiology of disease 20010201

• Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+.

  The Biochemical journal 20010201

• Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation.

  The Biochemical journal 20010201

• Wortmannin selectively enhances radiation-induced apoptosis in proliferative but not quiescent cells.

  International journal of radiation oncology, biology, physics 20010201

• Insulin-like growth factor-I is a potential trophic factor for amacrine cells.

  Journal of neurochemistry 20010201

• Involvement of PI 3-kinase in IGF-I stimulation of jejunal Na+-K+-ATPase activity and nutrient absorption.

  American journal of physiology. Gastrointestinal and liver physiology 20010201

• Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases.

  American journal of physiology. Gastrointestinal and liver physiology 20010201

• Molecular mechanisms for the antiapoptotic action of gastrin.

  American journal of physiology. Gastrointestinal and liver physiology 20010201

• Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle.

  Diabetes 20010201

• Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase.

  Pflugers Archiv : European journal of physiology 20010201

• [The involvement of phosphoinositide 3-kinase (PI3-Kinase) and phospholipase C gamma (PLC gamma) pathway in the morphine-induced supraspinal antinociception in the mouse].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20010201

• The insulin-stimulated cell surface presentation of low density lipoprotein receptor-related protein in 3T3-L1 adipocytes is sensitive to phosphatidylinositide 3-kinase inhibition.

  Biochemistry 20010123

• Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.

  The Journal of clinical investigation 20010115

• Regulation of intracellular trafficking of the EGF receptor by Rab5 in the absence of phosphatidylinositol 3-kinase activity.

  EMBO reports 20010115

• Regulation of phospholipase D (PLD) in growth plate chondrocytes by 24R,25-(OH)2D3 is dependent on cell maturation state (resting zone cells) and is specific to the PLD2 isoform.

  Biochimica et biophysica acta 20010115

• Regulation of glycogen synthesis by amino acids in cultured human muscle cells.

  The Journal of biological chemistry 20010112

• Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway.

  The Journal of biological chemistry 20010112

• Phosphatidylinositol 4,5-bisphosphate is acting as a signal molecule in alpha(1)-adrenergic pathway via the modulation of acetylcholine-activated K(+) channels in mouse atrial myocytes.

  The Journal of biological chemistry 20010105

• Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101

• Diacylglycerol kinase theta is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries.

  The Biochemical journal 20010101

• Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain.

  Journal of immunology (Baltimore, Md. : 1950) 20010101

• A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis.

  Molecular pharmacology 20010101

• Halothane increases smooth muscle protein phosphatase in airway smooth muscle.

  Anesthesiology 20010101

• Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes.

  Endocrinology 20010101

• Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling.

  Endocrinology 20010101

• Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin.

  Endocrinology 20010101

• Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5).

  Molecular endocrinology (Baltimore, Md.) 20010101

• Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.

  Diabetes 20010101

• Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry.

  Journal of immunological methods 20010101

• Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase.

  The international journal of biochemistry & cell biology 20010101

• Regulation of human neutrophil-mediated cartilage proteoglycan degradation by phosphatidylinositol-3-kinase.

  Immunology 20010101

• Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol.

  Journal of biomedical science 20010101

• Endothelins stimulate aldosterone secretion from dispersed rat adrenal zona glomerulosa cells, acting through ETB receptors coupled with the phospholipase C-dependent signaling pathway.

  Peptides 20010101

• Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

  Cancer research 20010101

• Survival activity of troglitazone in rat motoneurones.

  Journal of neurochemistry 20010101

• Phosphatidylinositol 3-kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP-dependent induction of differentiation in rat C6 glioma.

  Journal of neurochemistry 20010101

• Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway.

  RNA (New York, N.Y.) 20010101

• 17 beta-estradiol-BSA conjugates and 17 beta-estradiol regulate growth plate chondrocytes by common membrane associated mechanisms involving PKC dependent and independent signal transduction.

  Journal of cellular biochemistry 20010101

• Involvement of p70 S6 kinase in bone morphogenetic protein signaling: vascular endothelial growth factor synthesis by bone morphogenetic protein-4 in osteoblasts.

  Journal of cellular biochemistry 20010101

• Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury.

  Journal of cellular biochemistry 20010101

• Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells.

  Cellular signalling 20010101

• Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin.

  European journal of immunology 20010101

• Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway.

  Journal of diabetes and its complications 20010101

• Sensitizing effect of the phosphatidylinositol 3-kinase inhibitor wortmannin on thermal neutron irradiation with or without boron compound.

  Radiation medicine 20010101

• Cisplatinum and taxol induce different patterns of p53 phosphorylation.

  Neoplasia (New York, N.Y.) 20010101

• Bruton's tyrosine kinase associates with the actin-based cytoskeleton in activated platelets.

  Journal of cellular biochemistry 20010101

• [Effect of wortmannin on endocytosis of epidermal growth factor receptors].

  Tsitologiia 20010101

• Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

  BMC immunology 20010101

• Multiple signal transduction pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase in normal and tumoral target tissues.

  The Journal of steroid biochemistry and molecular biology 20010101

• Synthesis and function of 3-phosphorylated inositol lipids.

  Annual review of biochemistry 20010101

• Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.

  Cell biology international 20010101

• Asparagine uptake in rat hepatocytes: resolution of a paradox and insights into substrate-dependent transporter regulation.

  Amino acids 20010101

• Interleukin-1 beta induced synthesis of protein kinase C-delta and protein kinase C-epsilon in EL4 thymoma cells: possible involvement of phosphatidylinositol 3-kinase.

  Experimental and clinical immunogenetics 20010101

• Importance of Rho-kinase-mediated phosphorylation of myosin light chain in vasospasm.

  Acta neurochirurgica. Supplement 20010101

• Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay.

  Toxicology in vitro : an international journal published in association with BIBRA 20010101

• Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?

  Breast cancer research : BCR 20010101

• Mechanisms of glutamine transport in rat adipocytes and acute regulation by cell swelling.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101

• Regulation of apoptosis of synovial fibroblasts.

  Current directions in autoimmunity 20010101

• Role of p38(MAPK) in cell volume regulation of perfused rat liver.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101

• Effect of wortmannin and phorbol ester on Paramecium fluid-phase uptake in the presence of transferrin.

  European journal of histochemistry : EJH 20010101

• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  The Biochemical journal 20001001

• Phenylephrine protects neonatal rat cardiomyocytes from hypoxia and serum deprivation-induced apoptosis.

  Cell death and differentiation 20000901

• Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia.

  The Journal of biological chemistry 20000818

• Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells.

  Journal of hepatology 20000201

• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) inhibits nitric oxide production in cultured murine astrocytes.

  Pharmacological research 19991101

• Attenuation of focal adhesion kinase signaling following depletion of agonist-sensitive pools of phosphatidylinositol 4,5-bisphosphate.

  Journal of neurochemistry 19991101

• Caffeine inhibits the checkpoint kinase ATM.

  Current biology : CB 19991007

• Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.

  Clinical microbiology reviews 19991001

• Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism.

  Biochimica et biophysica acta 19990812

• Rapamycin inhibits didemnin B-induced apoptosis in human HL-60 cells: evidence for the possible involvement of FK506-binding protein 25.

  Immunology and cell biology 19990601

• Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230.

  Biochimica et biophysica acta 19990325

• Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells.

  The Journal of biological chemistry 19990108

• Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress.

  FEBS letters 19981211

• Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

  Proceedings of the National Academy of Sciences of the United States of America 19980915

• Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.

  Journal of neurochemistry 19980701

• Secretoneurin, a novel neuropeptide, is a potent chemoattractant for human eosinophils.

  Blood 19980301

• The novel insulinotropic mechanism of pimobendan: direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in beta-cells.

  Endocrinology 19980301

• Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

  Clinical cancer research : an official journal of the American Association for Cancer Research 19970701

• Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.

  The Journal of biological chemistry 19970214

• Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells.

  Diabetes 19970101

• Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.

  Molecular and cellular biology 19960401

• Thrombin stimulates wortmannin-inhibitable phosphoinositide 3-kinase and membrane blebbing in CHRF-288 cells.

  The Biochemical journal 19960315

• Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

  The Journal of biological chemistry 19931205

• Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association.

  Molecular endocrinology (Baltimore, Md.)