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The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release-Possible role of glutathione.
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Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures.
PloS one 20140101
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Plant growth stimulation in Prunus species plantlets by BTH or OTC treatments under in vitro conditions.
Journal of plant physiology 20120715
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Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats.
BMB reports 20120601
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Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120301
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L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF).
International journal of molecular sciences 20120101
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Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.
Alcoholism, clinical and experimental research 20111001
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L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma.
The journal of physiological sciences : JPS 20110901
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Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
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Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.
Investigative ophthalmology & visual science 20110701
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Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine.
American journal of respiratory cell and molecular biology 20110501
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In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity.
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Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy.
Neurochemical research 20110301
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Cytotoxicity of dentine bonding agents on human pulp cells is related to intracellular glutathione levels.
International endodontic journal 20101201
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Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels.
International endodontic journal 20100501
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Glutathione modulators reverse the pro-tumour effect of growth factors enhancing WiDr cell response to chemotherapeutic agents.
Anticancer research 20100401
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Benzothiadiazole and l-2-oxothiazolidine-4-carboxylic acid reduce the severity of Sharka symptoms in pea leaves: effect on antioxidative metabolism at the subcellular level.
Plant biology (Stuttgart, Germany) 20100101
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Procysteine increases alcohol-depleted glutathione stores in rat plantaris following a period of abstinence.
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Glutathione modulation reverses the growth-promoting effect of growth factors, improving the 5-fluorouracil antitumour response in WiDr colon cancer cells.
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The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF).
Iranian biomedical journal 20091001
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Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid.
Toxicology 20090919
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Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats.
Alcoholism, clinical and experimental research 20090801
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Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.
International journal of molecular medicine 20090801
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L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro.
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Normal saline induces oxidative stress in peritoneal mesothelial cells.
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Increased metal tolerance in Salix by nicotinamide and nicotinic acid.
Plant physiology and biochemistry : PPB 20080701
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Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
American journal of physiology. Heart and circulatory physiology 20080601
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A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome.
Critical care medicine 20080301
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Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation.
Pflugers Archiv : European journal of physiology 20080101
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Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress.
Canadian journal of microbiology 20080101
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Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.
Muscle & nerve 20071201
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Cytotoxicity of formaldehyde on human osteoblastic cells is related to intracellular glutathione levels.
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The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.
Fundamental & clinical pharmacology 20071001
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Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation.
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Effects of a bacterial lipid byproduct on human pulp fibroblasts in vitro.
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Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose.
Free radical biology & medicine 20070301
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Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Carcinogenesis 20070201
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Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L. plants.
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Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma.
Cancer immunology, immunotherapy : CII 20060801
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Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801
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An antioxidant modulates expression of receptor activator of NF-kappaB in asthma.
Experimental & molecular medicine 20060630
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Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.
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Antioxidants as novel agents for asthma.
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Effects of glutathione supplementation during peritoneal dialysis.
Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20060101
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A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.
Molecular pharmacology 20051101
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Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.
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Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201
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L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.
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Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.
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Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.
Neuroscience letters 20040617
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Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery.
Biological & pharmaceutical bulletin 20040301
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Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid.
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L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency.
Free radical biology & medicine 20030601
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Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.
Metabolism: clinical and experimental 20030601
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Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (Pringle maneuver) under hypovolemic conditions.
World journal of surgery 20030401
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The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.
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Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels.
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Glucose-induced changes in the phenotype of human peritoneal mesothelial cells: effect of L-2-oxothiazolidine carboxylic acid.
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In vivo monitoring of hepatic glutathione in anesthetized rats by 13C NMR.
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Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization.
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L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases.
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In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.
Archives of biochemistry and biophysics 20020115
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Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 20020101
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L-2-oxothiazolidine-4-carboxylate: an agent that modulates lipopolysaccharide-induced peritonitis in rats.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20020101
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Postepy higieny i medycyny doswiadczalnej 20020101
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Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101
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Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.
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Synthesis and in vitro anti-HIV activity in human monocyte-derived macrophages of 2-oxothiazolidine-4(R)-carboxylic acid derivatives.
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Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus.
Biochemical pharmacology 19990515
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Protective effects of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats.
The Journal of urology 19970501
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L-2-oxothiazolidine-4-carboxylic acid inhibits human immunodeficiency virus type 1 replication in mononuclear phagocytes and lymphocytes.
Clinical and diagnostic laboratory immunology 19970501
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Supplementation with L-2-oxothiazolidine-4-carboxylic acid, a cysteine precursor, does not protect against lipid peroxidation in puromycin aminonucleoside-induced nephropathy.
Experimental nephrology 19960101
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L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 19950201
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Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.
AIDS research and human retroviruses 19940801
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Role of oxygen free radicals in cocaine-induced vascular disruption in mice.
Teratology 19940301
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