197855-65-5 | Z-FA-FMK

Packsize	Purity	Availability	Price	Discounted Price
1mg	99+%	in stock	$51.00	$36.00
5mg	99+%	in stock	$156.00	$109.00
10mg	99+%	in stock	$233.00	$163.00

Description

• Catalog Number: AB07501
• Chemical Name: Z-FA-FMK
• CAS Number: 197855-65-5
• Molecular Formula: C21H23FN2O4
• Molecular Weight: 386.4167
• MDL Number: MFCD02684535
• SMILES: FCC(=O)C(NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C

Computed Properties

• Complexity: 517
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 10
• Undefined Atom Stereocenter Count: 1
• XLogP3: 3.3

Literature

• Z-FA.FMK activates duodenal epithelial cell proliferation through oxidative stress, NF-kappaB and IL-1beta in D-GalN/TNF-alpha-administered mice.

  Cell biology international 20100408

• Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo.

  Antiviral therapy 20100101

• Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol.

  Current eye research 20080901

• Effects of Z-FA.FMK on D-galactosamine/tumor necrosis factor-alpha-induced kidney injury and oxidative stress in mice : effects of Z-FA.FMK on TNF-alpha-mediated kidney injury.

  Molecular and cellular biochemistry 20080201

• The effect of Z-FA.FMK on D-galactosamine/TNF-alpha-induced liver injury in mice.

  Cell biochemistry and function 20070101

• The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.

  Journal of immunology (Baltimore, Md. : 1950) 20060915

• Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum.

  Brain research 20060203

• Role of lysosomal cathepsins in naphthazarin- and Fas-induced apoptosis in oral squamous cell carcinoma cells.

  Acta oto-laryngologica 20060101

• Incorporation of branched-chain fatty acid into cellular lipids and caspase-independent apoptosis in human breast cancer cell line, SKBR-3.

  Lipids in health and disease 20050101

• Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.

  Archives of dermatological research 20040701

• Caspase activity is essential for long-term potentiation.

  Journal of neuroscience research 20030915

• Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway.

  Molecular cancer therapeutics 20030301

• A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury.

  European journal of pharmacology 20021205

• The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage.

  Virology 20011125

• Cuticular collagen synthesis by Ascaris suum during development from the third to fourth larval stage: identification of a potential chemotherapeutic agent with a novel mechanism of action.

  The Journal of parasitology 20011001

• The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide.

  The Journal of biological chemistry 20010615

• Comparative histochemical, biochemical and immunocytochemical studies of cathepsin B in human gingiva.

  Journal of periodontal research 19940501