199986-75-9 | CVT-313

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$28.00	$19.00
5mg	98%	in stock	$68.00	$48.00
10mg	98%	in stock	$102.00	$71.00
25mg	98%	in stock	$172.00	$120.00
50mg	98%	in stock	$222.00	$155.00

Description

• Catalog Number: AB09305
• Chemical Name: CVT-313
• CAS Number: 199986-75-9
• Molecular Formula: C20H28N6O3
• Molecular Weight: 400.4747
• MDL Number: MFCD06411412
• SMILES: OCCN(c1nc(NCc2ccc(cc2)OC)c2c(n1)n(cn2)C(C)C)CCO

Computed Properties

• Complexity: 471
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 10
• XLogP3: 1.6

Literature

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis.

  The Journal of biological chemistry 20111021

• Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry.

  Journal of proteome research 20080601

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas.

  Cell cycle (Georgetown, Tex.) 20071201

• Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes.

  Journal of medicinal chemistry 20020606

• Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

  Science (New York, N.Y.) 19980724