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Effects of P2Y(1) receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel.
British journal of pharmacology 20120501
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Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats.
The Journal of physiology 20120401
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P2Y1 purinoceptor inhibition reduces extracellular signal-regulated protein kinase 1/2 phosphorylation in spinal cord and dorsal root ganglia: implications for cancer-induced bone pain.
Acta biochimica et biophysica Sinica 20120401
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Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
Assay and drug development technologies 20120201
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P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices.
Journal of neurophysiology 20120201
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Functional contribution of P2Y1 receptors to the control of coronary blood flow.
Journal of applied physiology (Bethesda, Md. : 1985) 20111201
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Prevention of extracellular ADP-induced ATP accumulation of the cultured rat spinal astrocytes via P2Y(1)-mediated inhibition of AMPK.
Neuroscience letters 20111010
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Local Ca2+ detection and modulation of synaptic release by astrocytes.
Nature neuroscience 20110911
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Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade.
Pain 20110801
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Regional functional specialization and inhibitory nitrergic and nonnitrergic coneurotransmission in the human esophagus.
American journal of physiology. Gastrointestinal and liver physiology 20110501
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ADP ribose is an endogenous ligand for the purinergic P2Y1 receptor.
Molecular and cellular endocrinology 20110210
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P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.
American journal of physiology. Cell physiology 20110201
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Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages.
Immunobiology 20110101
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Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
PloS one 20110101
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Involvement of P2X receptors in the regulation of insulin secretion, proliferation and survival in mouse pancreatic β-cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
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Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells.
PloS one 20110101
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Metabolic regulation of coronary vascular tone: role of hydrogen peroxide, purinergic components, and angiotensin.
European journal of pharmacology 20101025
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TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression.
Journal of neurochemistry 20101001
-
Facilitation of Ih channels by P2Y1 receptors activation in Mesencephalic trigeminal neurons.
Neuroscience letters 20100927
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Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress.
Investigative ophthalmology & visual science 20100801
-
Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder.
Basic & clinical pharmacology & toxicology 20100701
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Adenosine triphosphate stimulates RANKL expression through P2Y1 receptor-cyclo-oxygenase-dependent pathway in human periodontal ligament cells.
Journal of periodontal research 20100601
-
P2Y1 receptors mediate apamin-sensitive and -insensitive inhibitory junction potentials in murine colonic circular smooth muscle.
The Journal of pharmacology and experimental therapeutics 20100501
-
Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors.
Molecular and cellular neurosciences 20100401
-
AMP N(1)-oxide, a unique compound of royal jelly, induces neurite outgrowth from PC12 cells via signaling by protein kinase A independent of that by mitogen-activated protein kinase.
Evidence-based complementary and alternative medicine : eCAM 20100301
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Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells.
Journal of neurochemistry 20100301
-
Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes.
American journal of physiology. Cell physiology 20100301
-
Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia.
Glia 20100101
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CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells.
Journal of vascular research 20100101
-
Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
PloS one 20100101
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The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues.
Neurochemistry international 20091201
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Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat.
The Journal of comparative neurology 20091010
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Extracellular ADP regulates lesion-induced in vivo cell proliferation and death in the zebrafish retina.
Journal of neurochemistry 20091001
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Role of P2Y1 receptor in astroglia-to-neuron signaling at dorsal spinal cord.
Journal of neuroscience research 20090901
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P2 receptor-mediated signaling in spherical bushy cells of the mammalian cochlear nucleus.
Journal of neurophysiology 20090901
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Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion.
American journal of physiology. Regulatory, integrative and comparative physiology 20090801
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Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y1 purinoceptors in different myenteric neurons.
American journal of physiology. Gastrointestinal and liver physiology 20090701
-
The NANC relaxation of the human ileal longitudinal and circular muscles is inhibited by MRS 2179, a P2 purinoceptor antagonist.
Life sciences 20090619
-
Mechanism of activation and functional role of protein kinase Ceta in human platelets.
The Journal of biological chemistry 20090515
-
Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090301
-
Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome.
Blood cells, molecules & diseases 20090101
-
P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signaling.
Molecular pharmacology 20081201
-
Ca2+ signaling in injured in situ endothelium of rat aorta.
Cell calcium 20080901
-
Effects of P2Y1 receptor on glial fibrillary acidic protein and glial cell line-derived neurotrophic factor production of astrocytes under ischemic condition and the related signaling pathways.
Neuroscience bulletin 20080801
-
Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures.
Neuroscience letters 20080425
-
Functional evidence for purinergic inhibitory neuromuscular transmission in the mouse internal anal sphincter.
American journal of physiology. Gastrointestinal and liver physiology 20080401
-
Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle.
The Journal of pharmacology and experimental therapeutics 20080301
-
Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents.
Platelets 20080301
-
P2Y1 receptors mediate inhibitory neuromuscular transmission and enteric neuronal activation in small intestine.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080201
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Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons.
Journal of neurochemistry 20080101
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Possible role of extracellular nucleotides in ectopic ossification of human spinal ligaments.
Journal of pharmacological sciences 20080101
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GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.
BMC bioinformatics 20080101
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Inhibition of ATP-induced glutamate release by MRS2179 in cultured dorsal spinal cord astrocytes.
Pharmacology 20080101
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Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells.
Journal of cell science 20071215
-
Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon.
Regulatory peptides 20071204
-
P2Y receptor-activating nucleotides modulate cellular reactive oxygen species production in dissociated hippocampal astrocytes and neurons in culture independent of parallel cytosolic Ca(2+) rise and change in mitochondrial potential.
Journal of neuroscience research 20071115
-
The ADP receptor P2Y(1) mediates t-PA release in pigs during cardiac ischemia.
Journal of thrombosis and thrombolysis 20071001
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Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways.
Platelets 20070801
-
ATP release and hydrolysis contribute to rat pial arteriolar dilatation elicited by neuronal activation.
Experimental physiology 20070701
-
Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small intestine.
American journal of physiology. Gastrointestinal and liver physiology 20070601
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Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon.
British journal of pharmacology 20070501
-
Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques.
Thrombosis and haemostasis 20070301
-
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
American journal of physiology. Gastrointestinal and liver physiology 20070201
-
A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201
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P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20070131
-
ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors.
American journal of physiology. Regulatory, integrative and comparative physiology 20070101
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Mitochondrial calcium transport is regulated by P2Y1- and P2Y2-like mitochondrial receptors.
Journal of cellular biochemistry 20061101
-
Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors.
Biochemical pharmacology 20061016
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P2Y1 receptors mediate inhibitory purinergic neuromuscular transmission in the human colon.
American journal of physiology. Gastrointestinal and liver physiology 20061001
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Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides.
The European journal of neuroscience 20061001
-
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.
The Journal of biological chemistry 20060908
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P2Y receptor-mediated excitation in the posterior hypothalamus.
The European journal of neuroscience 20060901
-
Glucose induces glucagon release pulses antisynchronous with insulin and sensitive to purinoceptor inhibition.
Endocrinology 20060701
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Can the PFA-100 be modified to detect P2Y12 inhibition?
Journal of thrombosis and haemostasis : JTH 20060601
-
Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase.
FEBS letters 20060529
-
Differential coupling of the P2Y1 receptor to Galpha14 and Galphaq/11 proteins during the development of the rat salivary gland.
Archives of oral biology 20060501
-
Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine.
European journal of pharmacology 20060424
-
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.
European journal of pharmacology 20060318
-
Endothelium-dependent relaxation evoked by ATP and UTP in the aorta of P2Y2-deficient mice.
British journal of pharmacology 20060301
-
Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation.
Development (Cambridge, England) 20060201
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Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
Journal of neurochemistry 20051201
-
Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons.
European journal of pharmacology 20051003
-
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706
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Inhibition of purinoceptors amplifies glucose-stimulated insulin release with removal of its pulsatility.
Diabetes 20050701
-
The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range.
Naunyn-Schmiedeberg's archives of pharmacology 20050701
-
Metabotropic P2Y purinoceptor-mediated presynaptic and postsynaptic enhancement of cerebellar GABAergic transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050223
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ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells.
Circulation research 20050204
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Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201
-
Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate.
The Journal of pharmacology and experimental therapeutics 20041001
-
Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells.
Pflugers Archiv : European journal of physiology 20041001
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Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation.
British journal of pharmacology 20040801
-
The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented.
Journal of thrombosis and haemostasis : JTH 20040601
-
Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y(1) receptor antagonists.
Bioorganic & medicinal chemistry 20040401
-
ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells.
American journal of respiratory cell and molecular biology 20040301
-
N(6)-Methyldeoxyadenosine, a nucleoside commonly found in prokaryotes, induces C2C12 myogenic differentiation.
Biochemical and biophysical research communications 20040206
-
ATP modulates intracellular Ca2+ and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells.
The Journal of physiology 20031101
-
Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity.
Arteriosclerosis, thrombosis, and vascular biology 20031001
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Nucleotide coronary vasodilation in guinea pig hearts.
American journal of physiology. Heart and circulatory physiology 20030901
-
Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors.
Glia 20030901
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Slow excitatory synaptic transmission mediated by P2Y1 receptors in the guinea-pig enteric nervous system.
The Journal of physiology 20030715
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The platelet P2Y receptors as targets for new antithrombotic drugs.
Journal of thrombosis and haemostasis : JTH 20030601
-
Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
Journal of thrombosis and haemostasis : JTH 20030601
-
Induction of neurite outgrowth in PC12 cells by the bacterial nucleoside N6-methyldeoxyadenosine is mediated through adenosine A2a receptors and via cAMP and MAPK signaling pathways.
Biochemical and biophysical research communications 20030516
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P2Y receptor specific for diadenosine tetraphosphate in lung: selective inhibition by suramin, PPADS, Ip5I, and not by MRS-2197.
European journal of pharmacology 20030502
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Effects of inhibition of P2Y(1) and P2Y(12) on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry.
Thrombosis research 20030315
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P2Y receptor-mediated inhibition of voltage-dependent Ca2+ channels in rat dorsal root ganglion neurons.
Synapse (New York, N.Y.) 20030201
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P2Y(1) receptor activation inhibits NMDA receptor-channels in layer V pyramidal neurons of the rat prefrontal and parietal cortex.
Neurochemistry international 20030101
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The P2Y(1) receptor as a target for new antithrombotic drugs: a review of the P2Y(1) antagonist MRS-2179.
Cardiovascular drug reviews 20030101
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The relative importance of the ADP receptors, P2Y12 and P2Y1, in thrombin-induced platelet activation.
Thrombosis research 20030101
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Activation of adenosine and P2Y receptors by ATP in human peripheral nerve.
Naunyn-Schmiedeberg's archives of pharmacology 20021101
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Effects of dinucleoside polyphosphates on regulation of coronary vascular tone.
European journal of pharmacology 20020719
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P2Y(1) and P2Y(2) receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed.
British journal of pharmacology 20020701
-
2-Chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist: commentary on Boyer et al.
British journal of pharmacology 20020401
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2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist.
British journal of pharmacology 20020401
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Novel antagonists acting at the P2Y(1) purinergic receptor: synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques.
Journal of medicinal chemistry 20020214
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Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179.
British journal of pharmacology 20020101
-
Effects of P2Y(1) and P2Y(12) receptor antagonists on ADP-induced shape change of equine platelets: comparison with human platelets.
Platelets 20020101
-
The bacterial nucleoside N(6)-methyldeoxyadenosine induces the differentiation of mammalian tumor cells.
Biochemical and biophysical research communications 20010720
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Extracellular ADP is a powerful osteolytic agent: evidence for signaling through the P2Y(1) receptor on bone cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501
-
Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist.
Circulation 20010206
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Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.
European journal of pharmacology 20010202
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Endothelium-dependent, MRS2179-independent actions of uridine 5'-triphosphate in guinea pig aorta.
Proceedings of the Western Pharmacology Society 20010101
