201530-41-8 | 4-[bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid

Packsize	Purity	Availability	Price	Discounted Price
50mg	98%	in stock	$6.00	$4.00
250mg	98%	in stock	$9.00	$6.00
1g	95%	in stock	$30.00	$21.00
5g	98%	in stock	$57.00	$40.00
25g	98%	in stock	$169.00	$119.00
100g	98%	in stock	$650.00	$455.00

Description

• Catalog Number: AB10586
• Chemical Name: 4-[bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
• CAS Number: 201530-41-8
• Molecular Formula: C21H15N3O4
• Molecular Weight: 373.3615
• MDL Number: MFCD09751362
• SMILES: OC(=O)c1ccc(cc1)n1nc(nc1c1ccccc1O)c1ccccc1O

Computed Properties

• Complexity: 540
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 4
• XLogP3: 3.8

Literature

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• One step forward in health promotion.

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• Deferasirox for porphyria cutanea tarda: a pilot study.

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  European journal of haematology 20120501

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  Hepatology research : the official journal of the Japan Society of Hepatology 20110701

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  Toxicology letters 20110610

• Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function.

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  American journal of physiology. Gastrointestinal and liver physiology 20110601

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  Translational research : the journal of laboratory and clinical medicine 20110601

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  Transfusion 20110501

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  Leukemia research 20110501

• Chelation of cadmium by combining deferasirox and deferiprone in rats.

  Toxicology and industrial health 20110501

• In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin.

  Experimental parasitology 20110501

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  Angiology 20110501

• Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response.

  Cell and tissue research 20110501

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  American journal of hematology 20110501

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  Pediatric hematology and oncology 20110401

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  Pediatric blood & cancer 20110401

• Renal dysfunction in patients with thalassaemia.

  British journal of haematology 20110401

• Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome.

  British journal of haematology 20110401

• Removal of thallium by deferasirox in rats as biological model.

  Journal of applied toxicology : JAT 20110301

• Improved efficacy and tolerability of oral deferasirox by twice-daily dosing for patients with transfusion-dependent β-thalassemia.

  Pediatric blood & cancer 20110301

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  European journal of haematology 20110301

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  International journal of hematology 20110301

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  Haematologica 20110101

• Iron-induced cardiac damage: role of apoptosis and deferasirox intervention.

  The Journal of pharmacology and experimental therapeutics 20110101

• Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9.

  Molecular pharmacology 20110101

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  Haematologica 20110101

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  Journal of the National Comprehensive Cancer Network : JNCCN 20110101

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• Low prevalence of fibrosis in thalassemia major assessed by late gadolinium enhancement cardiovascular magnetic resonance.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20110101

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  Annals of tropical paediatrics 20110101

• Oral iron chelator deferasirox in the treatment of secondary hemochromatosis following bone marrow transplantation in a patient with severe aplastic anemia.

  Acta haematologica 20110101

• A case of well-tolerated and safe deferasirox administration during the first trimester of a spontaneous pregnancy in an advanced maternal age thalassemic patient.

  Acta haematologica 20110101

• Ethical issues of unrelated hematopoietic stem cell transplantation in adult thalassemia patients.

  BMC medical ethics 20110101

• Value of black blood T2* cardiovascular magnetic resonance.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20110101

• Gated myocardial perfusion scintigraphy in children with sickle cell anemia: correlation with echocardiography.

  Revista espanola de medicina nuclear 20110101

• Iron overload in polytransfused patients without heart failure is associated with subclinical alterations of systolic left ventricular function using cardiovascular magnetic resonance tagging.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20110101

• Deferasirox lacks in vitro activity against Fusarium and Scedosporium species and black molds.

  Virulence 20110101

• Rhizomucor and scedosporium infection post hematopoietic stem-cell transplant.

  Case reports in medicine 20110101

• The proceedings of the 19Th international conference on chelation held in London, United Kingdom: major changes in iron chelation therapy in the last 25 years using deferiprone (L1) has resulted in the complete treatment of iron overload.

  Hemoglobin 20110101

• Efficacy and safety of administration of oral iron chelator deferiprone in patients with early myelodysplastic syndrome.

  Hemoglobin 20110101

• A record of 1320 suspect, deferasirox-related, patient deaths reported in 2009: insufficient toxicity testing, low efficacy and lack of transparency may endanger the lives of iron loaded patients.

  Hemoglobin 20110101

• Epidemiology of invasive fungal infections in the mediterranean area.

  Mediterranean journal of hematology and infectious diseases 20110101

• Zygomycosis in Immunocompromised non-Haematological Patients.

  Mediterranean journal of hematology and infectious diseases 20110101

• Iron-chelating therapies in a transfusion-dependent thalassaemia population in Thailand: a cost-effectiveness study.

  Clinical drug investigation 20110101

• Myelodysplastic syndrome and histone deacetylase inhibitors: 'to be or not to be acetylated'?

  Journal of biomedicine & biotechnology 20110101

• Iron chelation with deferasirox in two patients with HFE hemochromatosis and chronic anemia.

  Acta haematologica 20110101

• Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20110101

• The management of iron chelation therapy: preliminary data from a national registry of thalassaemic patients.

  Anemia 20110101

• Epidemiology and treatment approaches in management of invasive fungal infections.

  Clinical epidemiology 20110101

• To 'umbrella' the gonads in transfusion rain.

  Journal of human reproductive sciences 20110101

• Terbium-sensitized fluorescence method for the determination of deferasirox in biological fluids and tablet formulation.

  Luminescence : the journal of biological and chemical luminescence 20110101

• Serum ferritin levels, socio-demographic factors and desferrioxamine therapy in multi-transfused thalassemia major patients at a government tertiary care hospital of Karachi, Pakistan.

  BMC research notes 20110101

• Iron chelation therapy for transfusional iron overload: a swift evolution.

  Hemoglobin 20110101

• On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20110101

• The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase.

  Acta haematologica 20110101

• The role of galenic innovation in improving treatment compliance and persistence: three case studies.

  ClinicoEconomics and outcomes research : CEOR 20110101

• Real-world use of iron chelators.

  Hematology. American Society of Hematology. Education Program 20110101

• Synthesis and biological evaluation of bidentate 3-hydroxypyridin-4-ones iron chelating agents.

  Research in pharmaceutical sciences 20110101

• Management of transfusional iron overload - differential properties and efficacy of iron chelating agents.

  Journal of blood medicine 20110101

• Recombinant human erythropoietin reduces plasminogen activator inhibitor and ameliorates pro-inflammatory responses following trauma.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• Efficacy and safety of Iranian made Deferasirox (Osveral®) in Iranian major thalassemic patients with transfusional iron overload: A one year prospective multicentric open-label non-comparative study.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• Safety and efficacy of high dose intravenous desferrioxamine for reduction of iron overload in sickle cell disease.

  Pediatric blood & cancer 20101215

• Clinical management of myelodysplastic syndromes: update of SIE, SIES, GITMO practice guidelines.

  Leukemia research 20101201

• Prospective assessment of effects on iron-overload parameters of deferasirox therapy in patients with myelodysplastic syndromes.

  Leukemia research 20101201

• Delineating parameters of iron overload in MDS patients treated with deferasirox.

  Leukemia research 20101201

• Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation.

  Journal of hepatology 20101201

• Deferasirox administration for the treatment of non-transfusional iron overload in patients with thalassaemia intermedia.

  British journal of haematology 20101201

• Iron overload in thalassemia and related conditions: therapeutic goals and assessment of response to chelation therapies.

  Hematology/oncology clinics of North America 20101201

• Deferasirox for managing iron overload in people with myelodysplastic syndrome.

  The Cochrane database of systematic reviews 20101110

• A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis.

  Hepatology (Baltimore, Md.) 20101101

• Myelodysplastic syndromes--many new drugs, little therapeutic progress.

  Mayo Clinic proceedings 20101101

• Restoration of hematopoiesis after iron chelation therapy with deferasirox in 2 children with severe aplastic anemia.

  Journal of pediatric hematology/oncology 20101101

• Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.

  Archives of toxicology 20101101

• Recent advances in the treatment of mucormycosis.

  Current infectious disease reports 20101101

• Iron chelation therapy with deferasirox in patients with aplastic anemia: a subgroup analysis of 116 patients from the EPIC trial.

  Blood 20101007

• Relation of chelation regimes to cardiac mortality and morbidity in patients with thalassaemia major: an observational study from a large Greek Unit.

  European journal of haematology 20101001

• Antifungal therapy in invasive fungal infections.

  Current opinion in pharmacology 20101001

• Renal Fanconi syndrome secondary to deferasirox: where there is smoke there is fire.

  Journal of pediatric hematology/oncology 20101001

• Iron chelation therapy for patients with sickle cell disease and iron overload.

  American journal of hematology 20101001

• Acquired proximal renal tubular dysfunction in β-thalassemia patients treated with deferasirox.

  Journal of pediatric hematology/oncology 20101001

• Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial.

  American journal of hematology 20101001

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• [Deferasirox--a new oral iron chelator--review].

  Zhongguo shi yan xue ye xue za zhi 20101001

• Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study.

  Leukemia research 20100901

• Deferasirox use after hematopoietic stem cell transplantation in pediatric patients with beta-thalassemia major: preliminary results.

  Pediatric hematology and oncology 20100901

• HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.

  PLoS pathogens 20100901

• Deferasirox for managing transfusional iron overload in people with sickle cell disease.

  The Cochrane database of systematic reviews 20100804

• A method to measure deferasirox in plasma using HPLC coupled with MS/MS detection and its potential application.

  Therapeutic drug monitoring 20100801

• Clinical evaluation of Deferasirox for removal of cadmium ions in rat.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20100801

• Changes in parameters of oxidative stress and free iron biomarkers during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndromes.

  Haematologica 20100801

• Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging.

  Haematologica 20100801

• Posttransplant oral iron-chelating therapy in patients with beta-thalassemia major.

  Pediatric hematology and oncology 20100801

• An instrument assessing satisfaction with iron chelation therapy: Psychometric testing from an open-label clinical trial.

  Advances in therapy 20100801

• Deferasirox induced liver injury in haemochromatosis.

  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20100801

• Pathogenesis and management of iron toxicity in thalassemia.

  Annals of the New York Academy of Sciences 20100801

• Combined iron chelation therapy.

  Annals of the New York Academy of Sciences 20100801

• Deferasirox--current knowledge and future challenges.

  Annals of the New York Academy of Sciences 20100801

• Ninth Cooley's Anemia Symposium: summary and perspective.

  Annals of the New York Academy of Sciences 20100801

• The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores.

  Blood 20100729

• Iron chelation therapy associated with improvement of hematopoiesis in transfusion-dependent patients.

  Transfusion 20100701

• Acute renal failure and Fanconi syndrome due to deferasirox.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100701

• Retrospective study on the combination of desferrioxamine and deferasirox for treatment of iron-overloaded thalassemic patients: first evidence of more than 2 years.

  Journal of pediatric hematology/oncology 20100701

• Introduction of higher doses of deferasirox: better efficacy but not effective iron removal from the heart and increased risks of serious toxicities.

  Expert opinion on drug safety 20100701

• Chelation in metal intoxication.

  International journal of environmental research and public health 20100701

• Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.

  Chemical research in toxicology 20100621

• A prospective study of iron overload management in allogeneic hematopoietic cell transplantation survivors.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100601

• Deferasirox decreases age-associated iron accumulation in the aging F344XBN rat heart and liver.

  Cardiovascular toxicology 20100601

• Daily alternating deferasirox and deferiprone therapy for 'hard-to-chelate' beta-thalassemia major patients.

  American journal of hematology 20100601

• The role of iron and chelators on infections in iron overload and non iron loaded conditions: prospects for the design of new antimicrobial therapies.

  Hemoglobin 20100601

• Iron chelation therapy in hereditary hemochromatosis and thalassemia intermedia: regulatory and non regulatory mechanisms of increased iron absorption.

  Hemoglobin 20100601

• Combined antifungal therapy, iron chelation and surgical resection as treatment of hepatic zygomycosis in a patient with haematological malignancy.

  Mycoses 20100501

• Complications and treatment of patients with β-thalassemia in France: results of the National Registry.

  Haematologica 20100501

• Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Deferasirox (Exjade) significantly improves cardiac T2* in heavily iron-overloaded patients with beta-thalassemia major.

  Annals of hematology 20100401

• Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes.

  Journal of enzyme inhibition and medicinal chemistry 20100401

• Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias.

  Haematologica 20100401

• Effects of deferasirox and deferiprone on cellular iron load in the human hepatoma cell line HepaRG.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20100401

• Gastric ulcer in a child treated with deferasirox.

  Pharmacy world & science : PWS 20100401

• In vitro time-kill activities of ciprofloxacin alone and in combination with the iron chelator deferasirox against Vibrio vulnificus.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20100401

• Transport of iron chelators and chelates across MDCK cell monolayers: implications for iron excretion during chelation therapy.

  International journal of hematology 20100401

• Iron chelation therapy in myelodysplastic syndromes.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100401

• Acute interstitial nephritis secondary to deferasirox causing acute renal injury needing short-term dialysis.

  Nephrology (Carlton, Vic.) 20100401

• Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia.

  Blood 20100325

• Cystatin C levels in patients with beta-thalassemia during deferasirox treatment.

  Blood cells, molecules & diseases 20100315

• [Deferasirox-induced delayed hypersensitivity syndrome].

  Medicina clinica 20100313

• Can homeopathy bring additional benefits to thalassemic patients on hydroxyurea therapy? Encouraging results of a preliminary study.

  Evidence-based complementary and alternative medicine : eCAM 20100301

• Safety issues of iron chelation therapy in patients with normal range iron stores including thalassaemia, neurodegenerative, renal and infectious diseases.

  Expert opinion on drug safety 20100301

• Effect of iron chelator deferasirox on chronic anemia and thrombocytopenia in a transfusion-dependent patient with myelodysplastic syndrome.

  International journal of hematology 20100301

• Ability of deferasirox to bind iron during measurement of iron.

  Clinical chemistry and laboratory medicine 20100301

• Charge states of deferasirox-ferric iron complexes.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20100301

• Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload.

  Journal of medicinal chemistry 20100211

• Iron overload and chelation therapy in patients with low-risk myelodysplastic syndromes with transfusion requirements.

  Annals of hematology 20100201

• Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers.

  Journal of clinical pharmacology 20100201

• The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis.

  The Journal of antimicrobial chemotherapy 20100201

• Deferasirox treatment may be associated with reversible renal Fanconi syndrome.

  American journal of hematology 20100201

• Deferasirox: oral, once daily iron chelator--an expert opinion.

  Indian journal of pediatrics 20100201

• Synthesis and antiproliferating activity of iron chelators of hydroxyamino-1,3,5-triazine family.

  Bioorganic & medicinal chemistry letters 20100115

• Treatment with deferasirox (Exjade) effectively decreases iron burden in patients with thalassaemia intermedia: results of a pilot study.

  British journal of haematology 20100101

• Effect of iron chelators on labile iron and oxidative status of thalassaemic erythroid cells.

  Acta haematologica 20100101

• Hyperchloremic metabolic acidosis due to deferasirox in a patient with beta thalassemia major.

  The Annals of pharmacotherapy 20100101

• Nanoparticle and iron chelators as a potential novel Alzheimer therapy.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Paradoxically increased ferritin level in a beta-thalassemia major patient following the start of deferasirox chelation therapy.

  Acta haematologica 20100101

• Iron overload in myelodysplastic syndromes: diagnosis and management.

  Cancer control : journal of the Moffitt Cancer Center 20100101

• Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells.

  BMC cancer 20100101

• Renal dysfunction in patients with beta-thalassemia major receiving iron chelation therapy either with deferoxamine and deferiprone or with deferasirox.

  Acta haematologica 20100101

• Long-term chelation therapy with deferasirox: effects on cardiac iron overload measured by T2* MRI.

  Clinical drug investigation 20100101

• Review of Journal of Cardiovascular Magnetic Resonance 2009.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20100101

• Red blood cell transfusion independence following the initiation of iron chelation therapy in myelodysplastic syndrome.

  Advances in hematology 20100101

• Production of metabolites as bacterial responses to the marine environment.

  Marine drugs 20100101

• Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20100101

• Improved treatment satisfaction and convenience with deferasirox in iron-overloaded patients with beta-Thalassemia: Results from the ESCALATOR Trial.

  Acta haematologica 20100101

• Iron overload in sickle cell disease.

  Advances in hematology 20100101

• Beta-thalassemia.

  Orphanet journal of rare diseases 20100101

• beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload.

  Advances in hematology 20100101

• Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers.

  BMC health services research 20100101

• Iron chelation therapy with deferasirox results in improvement of liver enzyme level in patients with iron overload-associated liver dysfunction.

  Case reports in medicine 20100101

• Deferasirox treatment interruption in a transfusion-requiring myelodysplastic patient led to loss of erythroid response.

  Acta haematologica 20100101

• A cost-utility and budget impact analysis of allogeneic hematopoietic stem cell transplantation for severe thalassemic patients in Thailand.

  BMC health services research 20100101

• Iron chelation therapy in myelodysplastic syndromes.

  Advances in hematology 20100101

• [Epidemiological and economic aspects of chelating therapy in the therapeutic center of thalassemia in Morocco].

  Revue medicale de Bruxelles 20100101

• [Diamond-Blackfan anemia. Case report].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101

• Cost effectiveness of deferasirox compared to desferrioxamine in the treatment of iron overload in lower-risk, transfusion-dependent myelodysplastic syndrome patients.

  Journal of medical economics 20100101

• Iron overload in patients undergoing hematopoietic stem cell transplantation.

  Advances in hematology 20100101

• HJV hemochromatosis, iron overload, and hypogonadism in a Brazilian man: treatment with phlebotomy and deferasirox.

  Acta haematologica 20100101

• Cardiac events and cardiac T2* in Egyptian children and young adults with beta-thalassemia major taking deferoxamine.

  Hematology/oncology and stem cell therapy 20100101

• Impact on cell to plasma ratio of miR-92a in patients with acute leukemia: in vivo assessment of cell to plasma ratio of miR-92a.

  BMC research notes 20100101

• The pro-BNP Serum Level and Echocardiographic Tissue Doppler Abnormalities in Patients with Beta Thalassemia Major.

  Clinical Medicine Insights. Cardiology 20100101

• Update on iron chelators in thalassemia.

  Hematology. American Society of Hematology. Education Program 20100101

• New treatments for myelodysplastic syndromes.

  Mediterranean journal of hematology and infectious diseases 20100101

• Transfusion independence in Diamond-Blackfan anemia after deferasirox therapy.

  Annals of hematology 20091201

• Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload.

  British journal of haematology 20091201

• Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients.

  British journal of haematology 20091201

• The effects of deferiprone and deferasirox on the structure and function of beta-thalassemia hemoglobin.

  Journal of biomolecular structure & dynamics 20091201

• Early detection of iron overload in the heart: a key role for MRI!

  The international journal of cardiovascular imaging 20091201

• Iron toxicity: optimizing chelation therapy across transfusion-dependent anaemias. Introduction.

  Blood reviews 20091201

• Iron chelation therapy in MDS: what have we learnt recently?

  Blood reviews 20091201

• Optimizing iron chelation strategies in beta-thalassaemia major.

  Blood reviews 20091201

• Recent advances in improving the management of sickle cell disease.

  Blood reviews 20091201

• Synthetic and natural iron chelators: therapeutic potential and clinical use.

  Future medicinal chemistry 20091201

• Deferasirox pharmacokinetics in patients with adequate versus inadequate response.

  Blood 20091105

• Fanconi syndrome due to deferasirox.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20091101

• Iron chelation therapy in the management of thalassemia: the Asian perspectives.

  International journal of hematology 20091101

• Hematopoietic recovery after administration of deferasirox for transfusional iron overload in a case of myelodysplastic syndrome.

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20091101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20091101

• Hepatitis C antiviral response in thalassemia: what is the role of liver iron concentration?

  Annals of hematology 20091001

• Adherence to deferasirox in children and adolescents with sickle cell disease during 1-year of therapy.

  Journal of pediatric hematology/oncology 20091001

• The role of iron and iron chelators in zygomycosis.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20091001

• Skin diseases in patients with beta-thalassemia major.

  International journal of dermatology 20091001

• Understanding iron overload: screening, monitoring, and caring for patients with transfusion-dependent anemias.

  Clinical journal of oncology nursing 20091001

• Myelodysplasia paranoia: iron as the new radon.

  Leukemia research 20090901

• Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells.

  American journal of respiratory cell and molecular biology 20090901

• ZYGOMYCOSIS: current approaches to management of patients with haematological malignancies.

  British journal of haematology 20090901

• Efficacy of curcuminoids in alleviation of iron overload and lipid peroxidation in thalassemic mice.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20090901

• Deferasirox removes cardiac iron and attenuates oxidative stress in the iron-overloaded gerbil.

  American journal of hematology 20090901

• Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006.

  Emerging infectious diseases 20090901

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090901

• Comparison of the effects of deferasirox, deferiprone, and deferoxamine on the growth and virulence of Vibrio vulnificus.

  Transfusion 20090801

• Pharmacoeconomic benefits of deferasirox in the management of iron overload syndromes.

  Expert review of pharmacoeconomics & outcomes research 20090801

• Iron chelation therapy in myelodysplastic syndrome - Cui bono?

  Leukemia 20090801

• Adult-onset erythropoietic porphyria in the setting of MDS.

  Archives of dermatology 20090801

• Iron is essential for oligodendrocyte genesis following intraspinal macrophage activation.

  Experimental neurology 20090701

• Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication.

  PLoS genetics 20090701

• [Pathogenesis of transfusional iron overload and iron chelation therapy].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20090701

• The treatment of secondary hemochromatosis.

  Deutsches Arzteblatt international 20090701

• Recent advances in the management of mucormycosis: from bench to bedside.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090615

• Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study.

  European journal of haematology 20090601

• Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia.

  European journal of haematology 20090601

• Oral iron chelation and the treatment of iron overload in a pediatric hematology center.

  Pediatric blood & cancer 20090501

• Deferasirox reduces iron overload in a murine model of juvenile hemochromatosis.

  Experimental biology and medicine (Maywood, N.J.) 20090501

• The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.

  Cancer science 20090501

• Deferasirox induces regression of iron overload in patients with myelodysplastic syndromes.

  European journal of clinical investigation 20090501

• Restoration of cardiac function by an iron chelator, deferasirox, in a patient with aplastic anemia and cardiac iron overload.

  International journal of hematology 20090501

• Managing iron overload in patients with myelodysplastic syndromes with oral deferasirox therapy.

  The oncologist 20090501

• Deferasirox does not induce QT/QTc-prolongation in healthy subjects.

  International journal of clinical pharmacology and therapeutics 20090501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090501

• Deferasirox in MDS patients with transfusion-caused iron overload--a phase-II study.

  Annals of hematology 20090401

• Deferasirox in pyruvate kinase deficiency.

  Annals of hematology 20090401

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20090401

• Reversal of iron-induced dilated cardiomyopathy during therapy with deferasirox in beta-thalassemia.

  Pediatric blood & cancer 20090301

• Cost analysis of iron-related complications in a single institute.

  The Korean journal of internal medicine 20090301

• Management of transfusional iron overload in Latin America: current outlook and expert panel recommendations.

  Hematology (Amsterdam, Netherlands) 20090201

• Satisfaction and adherence in patients with iron overload receiving iron chelation therapy as assessed by a newly developed patient instrument.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101

• Deferasirox for the treatment of iron overload associated with regular blood transfusions (transfusional haemosiderosis) in patients suffering with chronic anaemia: a systematic review and economic evaluation.

  Health technology assessment (Winchester, England) 20090101

• Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

  BMC medical genomics 20090101

• Early deferasirox treatment in a patient with myelodysplastic syndrome results in a long-term reduction in transfusion requirements.

  Acta haematologica 20090101

• The efficacy of iron chelator regimes in reducing cardiac and hepatic iron in patients with thalassaemia major: a clinical observational study.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20090101

• Oral iron chelators.

  Annual review of medicine 20090101

• Update on thalassemia treatment in Taiwan, including bone marrow transplantation, chelation therapy, and cardiomyopathy treatment effects.

  Hemoglobin 20090101

• A new era in iron chelation therapy: the design of optimal, individually adjusted iron chelation therapies for the complete removal of iron overload in thalassemia and other chronically transfused patients.

  Hemoglobin 20090101

• Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients.

  Hemoglobin 20090101

• Risk/benefit assessment, advantages over other drugs and targeting methods in the use of deferiprone as a pharmaceutical antioxidant in iron loading and non iron loading conditions.

  Hemoglobin 20090101

• Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.

  Retrovirology 20090101

• Update on the use of deferasirox in the management of iron overload.

  Therapeutics and clinical risk management 20090101

• Deferasirox (Exjade) for the treatment of iron overload.

  Acta haematologica 20090101

• Prevention of cardiomyopathy in transfusion-dependent homozygous thalassaemia today and the role of cardiac magnetic resonance imaging.

  Advances in hematology 20090101

• Managing myelodysplastic symptoms in elderly patients.

  Clinical interventions in aging 20090101

• Deferasirox: an update.

  Hemoglobin 20090101

• Update on survival in thalassemia major.

  Hemoglobin 20090101

• Yersiniabactin reduces the respiratory oxidative stress response of innate immune cells.

  PloS one 20090101

• [Severe thrombocytopenia and mild leucopenia associated with deferasirox therapy].

  Therapie 20090101

• A time-cost augmented economic evaluation of oral deferasirox versus infusional deferoxamine [corrected] for patients with iron overload in South Korea.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101

• Cardiac function and iron chelation in thalassemia major and intermedia: a review of the underlying pathophysiology and approach to chelation management.

  Mediterranean journal of hematology and infectious diseases 20090101

• Hematopietic stem cell transplantation in thalassemia and related disorders.

  Mediterranean journal of hematology and infectious diseases 20090101

• Hematopoietic stem cell transplantation in thalassemia and sickle cell disease. Unicenter experience in a multi-ethnic population.

  Mediterranean journal of hematology and infectious diseases 20090101

• Infections in thalassemia and hemoglobinopathies: focus on therapy-related complications.

  Mediterranean journal of hematology and infectious diseases 20090101

• Iron chelation therapy in thalassemia syndromes.

  Mediterranean journal of hematology and infectious diseases 20090101

• Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20081201

• Deferasirox plus ciprofloxacin combination therapy after rapid diagnosis of Vibrio vulnificus sepsis using real-time polymerase chain reaction.

  The Journal of infection 20081201

• Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment.

  Current opinion in infectious diseases 20081201

• The role of iron in patients after bone marrow transplantation.

  Blood reviews 20081201

• Long-term efficacy and safety of deferasirox.

  Blood reviews 20081201

• Update on toxicity and efficacy aspects of treatment with deferasirox and its implication on the morbidity and mortality of transfused iron loaded patients.

  Expert opinion on drug safety 20081101

• Current status in iron chelation in hemoglobinopathies.

  Current molecular medicine 20081101

• Acute interstitial nephritis due to deferasirox: a case report.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081001

• Absence of an effect of a single-dose deferasirox on the steady-state pharmacokinetics of digoxin.

  International journal of clinical pharmacology and therapeutics 20081001

• The costs of drugs used to treat myelodysplastic syndromes following National Comprehensive Cancer Network Guidelines.

  Journal of the National Comprehensive Cancer Network : JNCCN 20081001

• Hypogonadism, diabetes mellitus, hypothyroidism, hypoparathyroidism: incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre.

  Pediatric endocrinology reviews : PER 20081001

• Treatment of iron overload in thalassemia.

  Pediatric endocrinology reviews : PER 20081001

• Hypocalcemia in a dialysis patient treated with deferasirox for iron overload.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20080901

• Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference.

  British journal of haematology 20080901

• Long-term experience with deferasirox (ICL670), a once-daily oral iron chelator, in the treatment of transfusional iron overload.

  Expert opinion on pharmacotherapy 20080901

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20080901

• Targeting the lysosome: fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools.

  Journal of medicinal chemistry 20080814

• Absolute oral bioavailability and disposition of deferasirox in healthy human subjects.

  Journal of clinical pharmacology 20080801

• Acute kidney injury due to deferoxamine in a renal transplant patient.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080801

• Current approach to hemochromatosis.

  Blood reviews 20080701

• Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart.

  Magnetic resonance in medicine 20080701

• A safety, pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade, ICL670) in patients with transfusion-dependent anemias and iron-overload: a Phase I study in Japan.

  International journal of hematology 20080701

• Iron and hepatitis C: what can we learn from thalassemia major?

  Liver international : official journal of the International Association for the Study of the Liver 20080701

• Cost-utility analysis of deferasirox compared to standard therapy with desferrioxamine for patients requiring iron chelation therapy in the United Kingdom.

  Current medical research and opinion 20080601

• Inflammation and oxidant-stress in beta-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial.

  Haematologica 20080601

• Comment to: Development of lens opacities with peculiar characteristics in patients affected by thalassemia major on chelating treatment with deferasirox. Haematologica 2008;93:e9-10.

  Haematologica 20080601

• Clinical application of deferasirox: practical patient management.

  American journal of hematology 20080501

• Effect of deferasirox (ICL670) on arterial function in patients with beta-thalassaemia major.

  British journal of haematology 20080501

• Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders.

  Haematologica 20080501

• What is new in iron overload?

  European journal of pediatrics 20080401

• Aceruloplasminaemia with progressive atrophy without brain iron overload: treatment with oral chelation.

  Journal of neurology, neurosurgery, and psychiatry 20080401

• Effect of food, type of food, and time of food intake on deferasirox bioavailability: recommendations for an optimal deferasirox administration regimen.

  Journal of clinical pharmacology 20080401

• Oral iron chelators.

  Pediatric clinics of North America 20080401

• Iron overload in myelodysplastic syndromes (MDS) - diagnosis, management, and response criteria: a proposal of the Austrian MDS platform.

  European journal of clinical investigation 20080301

• Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver.

  The American journal of pathology 20080301

• Iron overload in myelodysplastic syndromes.

  Leukemia & lymphoma 20080301

• [Pathophysiology, diagnosis and treatment of anemia].

  Nihon rinsho. Japanese journal of clinical medicine 20080301

• [Iron overload and iron chelation therapy in transfusion-dependent patients].

  Nihon rinsho. Japanese journal of clinical medicine 20080301

• [Development trend in new therapeutic approaches for anemia].

  Nihon rinsho. Japanese journal of clinical medicine 20080301

• Electrocatalytic oxidation and determination of deferasirox and deferiprone on a nickel oxyhydroxide-modified electrode.

  Analytical biochemistry 20080215

• Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study.

  European journal of haematology 20080201

• The heart in transfusion dependent homozygous thalassaemia today--prediction, prevention and management.

  European journal of haematology 20080201

• Relative bioavailability of deferasirox tablets administered without dispersion and dispersed in various drinks.

  International journal of clinical pharmacology and therapeutics 20080201

• Strides made in red blood cell disorders, but substantial barriers to care remain.

  JAMA 20080130

• Transfusion-dependent thalassaemia: a new era.

  The Medical journal of Australia 20080121

• Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy.

  The Biochemical journal 20080115

• Effect of transfusional iron intake on response to chelation therapy in beta-thalassemia major.

  Blood 20080115

• Development of lens opacities with peculiar characteristics in patients affected by thalassemia major on chelating treatment with deferasirox (ICL670) at the Pediatric Clinic in Monza, Italy.

  Haematologica 20080101

• Ethical issues and risk/benefit assessment of iron chelation therapy: advances with deferiprone/deferoxamine combinations and concerns about the safety, efficacy and costs of deferasirox.

  Hemoglobin 20080101

• Iron and the liver: update 2008.

  Journal of hepatology 20080101

• Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial.

  Acta haematologica 20080101

• Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes.

  International journal of hematology 20080101

• Overview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload.

  International journal of hematology 20080101

• Body iron metabolism and pathophysiology of iron overload.

  International journal of hematology 20080101

• Iron chelation therapy in the myelodysplastic syndromes and aplastic anemia: a review of experience in South Korea.

  International journal of hematology 20080101

• Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20080101

• Deferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosis.

  Acta haematologica 20080101

• Gateways to clinical trials. July-August 2008.

  Methods and findings in experimental and clinical pharmacology 20080101

• Safety and efficacy of combined chelation therapy with deferasirox and deferoxamine in a gerbil model of iron overload.

  Acta haematologica 20080101

• Ethical issues and risk/benefit assessment of iron chelation therapy: advances with deferiprone/deferoxamine combinations and concerns about the safety, efficacy and costs of deferasirox [Kontoghiorghes GJ, Hemoglobin 2008; 32(1-2):1-15.].

  Hemoglobin 20080101

• Transparency and access to full information for the fatal or serious toxicity risks, low efficacy and high price of deferasirox, could increase the prospect of improved iron chelation therapy worldwide.

  Hemoglobin 20080101

• Clinical relevance of anemia and transfusion iron overload in myelodysplastic syndromes.

  Hematology. American Society of Hematology. Education Program 20080101

• Iron loading and its clinical implications.

  American journal of hematology 20071201

• Concepts and goals in the management of transfusional iron overload.

  American journal of hematology 20071201

• Novel treatment options for transfusional iron overload in patients with myelodysplastic syndromes.

  Leukemia research 20071201

• Iron chelators ICL670 and 311 inhibit HIV-1 transcription.

  Virology 20071025

• Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism.

  Cell proliferation 20071001

• Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review.

  Transfusion 20071001

• Deferasirox: for iron overload: only a third-line option.

  Prescrire international 20071001

• Deferasirox for transfusion-related iron overload: a clinical review.

  Clinical therapeutics 20071001

• Deferiprone in the treatment of transfusion-dependent thalassemia: a review and perspective.

  Therapeutics and clinical risk management 20071001

• The iron chelator deferasirox protects mice from mucormycosis through iron starvation.

  The Journal of clinical investigation 20070904

• Coordination chemistry and biology of chelators for the treatment of iron overload disorders.

  Dalton transactions (Cambridge, England : 2003) 20070814

• Iron chelation, quo vadis?

  Current opinion in chemical biology 20070801

• Light and shadows in the iron chelation treatment of haematological diseases.

  British journal of haematology 20070801

• Current status of iron overload and chelation with deferasirox.

  Indian journal of pediatrics 20070801

• Deferasirox: the new oral iron chelator.

  Indian pediatrics 20070801

• Lenalidomide: a brief review of its therapeutic potential in myelodysplastic syndromes.

  Therapeutics and clinical risk management 20070801

• Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy.

  Experimental hematology 20070701

• Correction of anemia in a transfusion-dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade, ICL670).

  European journal of haematology 20070601

• Exjade(R) (deferasirox, ICL670) in the treatment of chronic iron overload associated with blood transfusion.

  Therapeutics and clinical risk management 20070601

• Cognitive declines therapy by iron burden reduction.

  Archives of internal medicine 20070528

• Deferasirox: uncertain future following renal failure fatalities, agranulocytosis and other toxicities.

  Expert opinion on drug safety 20070501

• Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia.

  Clinical therapeutics 20070501

• Deferasirox.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070315

• Chelation therapy for iron overload.

  Current gastroenterology reports 20070301

• A review of deferasirox, bortezomib, dasatinib, and cyclosporine eye drops: possible uses and known side effects in cutaneous medicine.

  Journal of drugs in dermatology : JDD 20070301

• A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease.

  British journal of haematology 20070201

• Risk-based management of myelodysplastic syndrome.

  Oncology (Williston Park, N.Y.) 20070101

• Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective.

  PharmacoEconomics 20070101

• Recent developments in iron chelation therapy.

  Klinische Padiatrie 20070101

• Deferasirox : a review of its use in the management of transfusional chronic iron overload.

  Drugs 20070101

• Quality of life related to oral versus subcutaneous iron chelation: a time trade-off study.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20070101

• [Post transfusionnal iron overload].

  La Revue du praticien 20061215

• Deferasirox for the treatment of chronic iron overload in transfusional hemosiderosis.

  Oncology (Williston Park, N.Y.) 20061201

• Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences.

  Blood 20061101

• Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil.

  Translational research : the journal of laboratory and clinical medicine 20061101

• Phase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with beta-thalassemia major.

  Haematologica 20061001

• Deferasirox: An effective once-daily orally active iron chelator.

  Drugs of today (Barcelona, Spain : 1998) 20061001

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20061001

• Does liver biopsy overestimate liver iron concentration?

  Blood 20060901

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060901

• Investigational agents for sickle cell disease.

  Expert opinion on investigational drugs 20060801

• New drugs 06, part II.

  Nursing 20060801

• The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox.

  European journal of pharmacology 20060717

• Deferasirox versus deferoxamine.

  Blood 20060715

• The oral chelator deferasirox--a new perspective for patients with iron overload.

  Haematologica 20060701

• Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload.

  Haematologica 20060701

• In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human.

  Drug metabolism and disposition: the biological fate of chemicals 20060601

• Deferasirox--an oral agent for chronic iron overload.

  The Annals of pharmacotherapy 20060601

• Effective new treatments of iron overload in thalassaemia using the ICOC combination therapy protocol of deferiprone (L1) and deferoxamine and of new chelating drugs.

  Haematologica 20060601

• Modulation of cell proliferation in rat liver cell cultures by new calix[4]arenes.

  Journal of enzyme inhibition and medicinal chemistry 20060601

• A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia.

  Blood 20060501

• Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions.

  Blood 20060501

• Deferasirox (Exjade): a new iron chelator.

  The Medical letter on drugs and therapeutics 20060424

• New chelation therapies and emerging chelating drugs for the treatment of iron overload.

  Expert opinion on emerging drugs 20060301

• Exjade (ICL 670): A new oral iron chelator.

  The Journal of the Association of Physicians of India 20060301

• Iron chelation therapy for myelodysplastic syndrome: if and when.

  Mayo Clinic proceedings 20060201

• Myelodysplastic syndromes: iron overload consequences and current chelating therapies.

  Journal of the National Comprehensive Cancer Network : JNCCN 20060101

• Oral drug for iron overload.

  FDA consumer 20060101

• New drugs: ramelteon, tipranavir, nepafenac, and deferasirox.

  Journal of the American Pharmacists Association : JAPhA 20060101

• Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers.

  Hemoglobin 20060101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060101

• The impact of iron overload and its treatment on quality of life: results from a literature review.

  Health and quality of life outcomes 20060101

• [Clinical findings and therapy of classical hereditary haemochromatosis (type 1)].

  Deutsche medizinische Wochenschrift (1946) 20051216

• Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells.

  Blood 20051101

• New therapies for sickle cell disease.

  Hematology/oncology clinics of North America 20051001

• Effects of ICL670 (deferasirox) on cardiac iron concentrations.

  Lancet (London, England) 20050901

• Molecule of the month. Deferasirox.

  Drug news & perspectives 20050901

• Deferasirox (ICL670; Exjade(R)), a Novel Orally Available Iron Chelator for Correction of Transfusion-Associated Iron Overload.

  Supportive cancer therapy 20050701

• Iron-chelating therapy with the new oral agent ICL670 (Exjade).

  Best practice & research. Clinical haematology 20050601

• Monitoring and treatment of iron overload: state of the art and new approaches.

  Seminars in hematology 20050401

• Treating iron overload: the state of the art.

  Seminars in hematology 20050401

• Iron chelation therapy.

  Current hematology reports 20050301

• Deferasirox Novartis.

  Current opinion in investigational drugs (London, England : 2000) 20050301

• The Egyptian experience with oral iron chelators.

  Hematology (Amsterdam, Netherlands) 20050101

• Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations.

  Current medicinal chemistry 20050101

• Molecular factors and mechanisms affecting iron and other metal excretion or absorption in health and disease: the role of natural and synthetic chelators.

  Current medicinal chemistry 20050101

• Objectives and mechanism of iron chelation therapy.

  Annals of the New York Academy of Sciences 20050101

• The design of orally active iron chelators.

  Annals of the New York Academy of Sciences 20050101

• Evaluation of ICL670, a once-daily oral iron chelator in a phase III clinical trial of beta-thalassemia patients with transfusional iron overload.

  Annals of the New York Academy of Sciences 20050101

• Monitoring long-term efficacy of iron chelation treatment with biomagnetic liver susceptometry.

  Annals of the New York Academy of Sciences 20050101

• Acceptance of the 2003 John Howland Award: a journey in clinical research.

  Pediatric research 20040801

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040101

• The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin.

  Free radical biology & medicine 20031201

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20031101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20030901

• Do we need more iron-chelating drugs?

  Lancet (London, England) 20030809

• Development of tridentate iron chelators: from desferrithiocin to ICL670.

  Current medicinal chemistry 20030601

• Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia.

  Journal of clinical pharmacology 20030601

• Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial.

  Lancet (London, England) 20030510

• Gateways to clinical trials. March 2003.

  Methods and findings in experimental and clinical pharmacology 20030301

• Clinical research: a tale of two studies.

  Transactions of the American Clinical and Climatological Association 20030101

• ICL670A: preclinical profile.

  Advances in experimental medicine and biology 20020101

• Assessment of antimalarial effect of ICL670A on in vitro cultures of Plasmodium falciparum.

  British journal of haematology 20011201

• Plasma deproteinization by precipitation and filtration in the 96-well format.

  Journal of pharmaceutical and biomedical analysis 20010701

• Determination of a new oral iron chelator, ICL670, and its iron complex in plasma by high-performance liquid chromatography and ultraviolet detection.

  Journal of chromatography. B, Biomedical sciences and applications 20010505

• Practice of solid-phase extraction and protein precipitation in the 96-well format combined with high-performance liquid chromatography-ultraviolet detection for the analysis of drugs in plasma and brain.

  Journal of chromatography. B, Biomedical sciences and applications 20010415

• ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture.

  Blood 20010215