201677-61-4 | Sivelestat sodium hydrate

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$45.00	$32.00
100mg	98%	in stock	$125.00	$88.00
250mg	98%	in stock	$248.00	$174.00
1g	98%	in stock	$607.00	$425.00

Description

• Catalog Number: AB10694
• Chemical Name: Sivelestat sodium hydrate
• CAS Number: 201677-61-4
• Molecular Formula: C20H30N2NaO11S
• Molecular Weight: 529.5138
• MDL Number: MFCD01937969
• SMILES: OC(=O)CNC(=O)c1ccccc1NS(=O)(=O)c1ccc(cc1)OC(=O)C(C)(C)C.O.O.O.O.[Na]

Computed Properties

• Complexity: 738
• Covalently-Bonded Unit Count: 6
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 9

Literature

• Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.

  Experimental lung research 20121101

• Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.

  International journal of biological macromolecules 20121001

• Recent advancements of total aortic arch replacement.

  The Journal of thoracic and cardiovascular surgery 20120701

• The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.

  Surgery today 20120701

• Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601

• Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women.

  Journal of perinatology : official journal of the California Perinatal Association 20120601

• The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection.

  World journal of surgery 20120501

• Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9.

  Journal of leukocyte biology 20120401

• Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein.

  Multiple sclerosis (Houndmills, Basingstoke, England) 20120401

• Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.

  Experimental lung research 20120201

• Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.

  Pulmonary pharmacology & therapeutics 20120201

• Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.

  Anticancer research 20120101

• Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs.

  Journal of biomedical science 20120101

• Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.

  Drug design, development and therapy 20120101

• Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries.

  Journal of physiology and biochemistry 20111201

• Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study.

  Pulmonary pharmacology & therapeutics 20111001

• AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.

  The Journal of pharmacology and experimental therapeutics 20111001

• Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration.

  Shock (Augusta, Ga.) 20110901

• The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide.

  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20110801

• Effects of sivelestat on bronchial inflammatory responses after esophagectomy.

  International journal of molecular medicine 20110801

• Optimal period for the prophylactic administration of neutrophil elastase inhibitor for patients with esophageal cancer undergoing esophagectomy.

  World journal of surgery 20110701

• Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer.

  The British journal of surgery 20110701

• Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes.

  Digestive diseases and sciences 20110601

• Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats.

  BJU international 20110101

• The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.

  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20110101

• Influence of neutrophil elastase inhibitor on the postoperative course in patients with esophageal cancer after transthoracic esophagectomy.

  Hepato-gastroenterology 20110101

• Prognostic factors in gastrointestinal perforation.

  Hepato-gastroenterology 20110101

• The effect of selective neutrophil elastase inhibitor on pancreatic islet yields and functions in rat with hypercytokinemia.

  Annals of transplantation 20110101

• Neutrophil elastase inhibitor restores gut ischemia reperfusion-induced impairment of gut immunity with reduced plasma interleukin-6 concentrations in mice.

  Surgical infections 20101201

• Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture.

  Journal of anesthesia 20101201

• A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction.

  Surgery today 20101101

• Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.

  The American journal of pathology 20101001

• In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.

  Experimental lung research 20101001

• Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.

  European journal of pharmacology 20100901

• Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model.

  International journal of dermatology 20100901

• Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation.

  Transplantation 20100815

• Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.

  Journal of anesthesia 20100801

• Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema.

  Hypertension research : official journal of the Japanese Society of Hypertension 20100701

• Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.

  Interactive cardiovascular and thoracic surgery 20100601

• Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.

  Translational research : the journal of laboratory and clinical medicine 20100601

• The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.

  Transplantation 20100515

• Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.

  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20100501

• Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.

  Shock (Augusta, Ga.) 20100501

• The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.

  The Journal of trauma 20100401

• Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection.

  The Thoracic and cardiovascular surgeon 20100401

• Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.

  Shock (Augusta, Ga.) 20100101

• Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus.

  Internal medicine (Tokyo, Japan) 20100101

• Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion.

  Platelets 20100101

• Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.

  Internal medicine (Tokyo, Japan) 20100101

• Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.

  Experimental lung research 20091201

• A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery.

  Interactive cardiovascular and thoracic surgery 20090801

• Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.

  The Journal of surgical research 20090801

• Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia.

  Interactive cardiovascular and thoracic surgery 20090601

• Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.

  Interactive cardiovascular and thoracic surgery 20090601

• Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401

• Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.

  Brain research 20090309

• Sivelestat treatment for acute respiratory distress syndrome in an infant.

  Journal of anesthesia 20090101

• Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.

  Pulmonary pharmacology & therapeutics 20081201

• The effect of sivelestat sodium on post-cardiopulmonary bypass acute lung injury in a neonatal piglet model.

  Interactive cardiovascular and thoracic surgery 20081001

• Protective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study.

  The Journal of cardiovascular surgery 20081001

• Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20081001

• [Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20081001

• A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.

  Inflammation 20080801

• Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs.

  Clinical and experimental pharmacology & physiology 20080701

• Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer.

  General thoracic and cardiovascular surgery 20080701

• Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.

  European journal of pharmacology 20080610

• Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.

  Respirology (Carlton, Vic.) 20080601

• Sivelestat and its role in tissue reperfusion injury.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080601

• [Effect of sivelestat sodium on acute lung injury after acute aortic dissection].

  Kyobu geka. The Japanese journal of thoracic surgery 20080601

• [Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080601

• Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist.

  Journal of cardiovascular pharmacology 20080501

• Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.

  Molecular and cellular biochemistry 20080401

• [Case of severe transfusion-related acute lung injury during coronary artery bypass surgery].

  Masui. The Japanese journal of anesthesiology 20080401

• [A case of lung adenocarcinoma effectively treated with sivelestat and corcicosteroid for drug-induced lung disease due to gefitinib].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080301

• Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.

  Nephrology (Carlton, Vic.) 20080201

• Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat.

  Internal medicine (Tokyo, Japan) 20080101

• Usefulness of a selective neutrophil elastase inhibitor (sivelestat) in septic ARDS patients after gastrointestinal surgery.

  Hepato-gastroenterology 20080101

• A neutrophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardiopulmonary bypass.

  Journal of anesthesia 20080101

• Angiogenic activity of bFGF and VEGF suppressed by proteolytic cleavage by neutrophil elastase.

  Biochemical and biophysical research communications 20071214

• Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis.

  International journal of molecular medicine 20071201

• Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20071101

• [Case of fulminant idiopathic interstitial pneumonia treated by sodium siverlestat (Elaspol) and steroid pulse therapy following extracorporeal lung assist (ECLA)].

  Masui. The Japanese journal of anesthesiology 20071001

• Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.

  European journal of pharmacology 20070924

• [Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma].

  Gan to kagaku ryoho. Cancer & chemotherapy 20070801

• Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.

  British journal of pharmacology 20070701

• Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits.

  Shock (Augusta, Ga.) 20070701

• [Outcome of patients with acute exacerbation of idiopathic interstitial fibrosis (IPF) treated with sivelestat and the prognostic value of serum KL-6 and surfactant protein D].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070601

• Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy.

  The British journal of surgery 20070501

• [A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070501

• Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070401

• Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.

  Experimental lung research 20070301

• A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.

  International journal of molecular medicine 20070201

• Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines.

  Oncology reports 20070101

• Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.

  The Annals of thoracic surgery 20070101

• Invited commentary.

  The Annals of thoracic surgery 20070101

• Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.

  Surgery today 20070101

• Neutrophil elastase as a predicting factor for development of acute lung injury.

  Internal medicine (Tokyo, Japan) 20070101

• Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.

  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20070101

• [A case of idiopathic ARDS treated by sivelestat sodium and fluid management based on extravascular lung water index].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20061201

• Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases.

  European journal of haematology 20061101

• ICAM-1 signal transduction in cells stimulated with neutrophil elastase.

  Digestive diseases and sciences 20061101

• [Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity].

  Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20061101

• Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.

  Cancer science 20061001

• The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.

  The Thoracic and cardiovascular surgeon 20060901

• Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.

  Transplantation proceedings 20060901

• [Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study].

  Masui. The Japanese journal of anesthesiology 20060801

• Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters.

  Shock (Augusta, Ga.) 20060701

• [Sivelestat sodium for aspiration-related acute lung injury: a review and analysis of published case reports].

  Masui. The Japanese journal of anesthesiology 20060601

• Application of chemical arrays in screening elastase inhibitors.

  Combinatorial chemistry & high throughput screening 20060601

• A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.

  The Journal of trauma 20060501

• Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.

  Journal of gastroenterology 20060401

• ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbits.

  The Journal of thoracic and cardiovascular surgery 20060301

• Update in ARDS management: recent randomized controlled trials that changed our practice.

  Cleveland Clinic journal of medicine 20060301

• Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome.

  Journal of anesthesia 20060101

• [Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060101

• Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.

  Surgery today 20060101

• Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.

  Journal of anesthesia 20060101

• Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.

  Journal of anesthesia 20060101

• Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate.

  Internal medicine (Tokyo, Japan) 20060101

• Usefulness of sivelestat sodium administration in patients with aspiration pneumonia.

  Journal of anesthesia 20060101

• Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2).

  Internal medicine (Tokyo, Japan) 20060101

• Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction.

  Research communications in molecular pathology and pharmacology 20060101

• Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients.

  The Tohoku journal of experimental medicine 20051001

• [Clinical experience of sivelestat sodium hydrate for severe reexpansion pulmonary edema; report of a case].

  Kyobu geka. The Japanese journal of thoracic surgery 20051001

• Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20051001

• Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation.

  The Annals of thoracic surgery 20050801

• Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.

  Critical care medicine 20050801

• [Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy].

  Masui. The Japanese journal of anesthesiology 20050801

• Case with bromine exposure leading to respiratory insufficiency.

  Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20050401

• Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.

  Shock (Augusta, Ga.) 20050201

• Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome.

  PharmacoEconomics 20050101

• Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.

  Pulmonary pharmacology & therapeutics 20050101

• Neutrophil elastase inhibitor ameliorates reperfusion injury in a canine model of lung transplantation.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20050101

• Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20041201

• Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.

  Inflammation 20041201

• [A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20041101

• Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome.

  Anesthesia and analgesia 20040901

• [Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy].

  Masui. The Japanese journal of anesthesiology 20040901

• Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study.

  Critical care medicine 20040801

• Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.

  Intensive care medicine 20040501

• Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.

  European journal of pharmacology 20040319

• Relationship between neutrophil elastase and acute lung injury in humans.

  Pulmonary pharmacology & therapeutics 20040101

• Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046.

  Biochemical and biophysical research communications 20031003

• [Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030801

• Effect of sivelestat, an inhibitor of neutrophil elastase, on rapidly progressive glomerulonephritis.

  Clinical nephrology 20030801

• The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury.

  Transplant international : official journal of the European Society for Organ Transplantation 20030501

• A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.

  Chest 20030401

• Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.

  Bioorganic & medicinal chemistry letters 20020902

• Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice.

  Shock (Augusta, Ga.) 20020801

• Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.

  Critical care medicine 20020501

• Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils.

  Alimentary pharmacology & therapeutics 20020401

• Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats.

  The European journal of surgery = Acta chirurgica 20020101

• Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion.

  Journal of applied physiology (Bethesda, Md. : 1985) 20011001

• A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.

  Journal of neurochemistry 20010901

• Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.

  European journal of pharmacology 20010824

• Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20010801

• Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.

  Journal of leukocyte biology 20010201