20311-51-7 | Solamargine

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥95%	in stock	$88.00	$62.00
5mg	98%	in stock	$289.00	$202.00
10mg	≥95%	in stock	$476.00	$333.00
20mg		in stock	$478.00	$335.00

Description

• Catalog Number: AF32689
• Chemical Name: Solamargine
• CAS Number: 20311-51-7
• Molecular Formula: C45H73NO15
• Molecular Weight: 868.0588
• MDL Number: MFCD30207844
• SMILES: OC[C@H]1O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@H](C)[C@]3(O4)CC[C@H](CN3)C)C)C2)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O

Computed Properties

• Complexity: 1610
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 26
• Heavy Atom Count: 61
• Hydrogen Bond Acceptor Count: 16
• Hydrogen Bond Donor Count: 9
• Rotatable Bond Count: 7
• XLogP3: 1.1

Literature

• Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.

  Fitoterapia 20120901

• Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do they also prime the immune system resulting in long-term protection against cancer?

  Planta medica 20120301

• In situ RBL receptor visualization and its mediated anticancer activity for solasodine rhamnosides.

  Chembiochem : a European journal of chemical biology 20111104

• [Extraction, purification technology and antineoplastic effects of solamargine].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

• Quantitative determination and pharmacokinetic study of solamargine in rat plasma by liquid chromatography-mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20110715

• [Simultaneous determination of three steroidal alkaloids from Solanum Nigrum by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

• Total synthesis of solamargine.

  Bioorganic & medicinal chemistry letters 20110515

• Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells.

  Cancer chemotherapy and pharmacology 20110401

• Technology of compact MAb and its application for medicinal plant breeding named as missile type molecular breeding.

  Current drug discovery technologies 20110301

• Simultaneous determination of three steroidal glycoalkaloids in Solanum xanthocarpum by high performance thin layer chromatography.

  Journal of pharmaceutical and biomedical analysis 20110220

• Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells.

  Life sciences 20110214

• A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100901

• Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu.

  Bioscience reports 20090201

• Biological activity of alkaloids from Solanum dulcamara L.

  Natural product research 20090101

• Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin.

  Chemical research in toxicology 20080201

• Downregulation of HER2/neu receptor by solamargine enhances anticancer drug-mediated cytotoxicity in breast cancer cells with high-expressing HER2/neu.

  Cell biology and toxicology 20080101

• Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071101

• Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells.

  Molecular nutrition & food research 20070801

• Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.

  Journal of natural products 20070201

• Impaired female sexual behavior of rat offspring exposed to Solanum lycocarpum unripe fruits during gestation and lactation: lack of hormonal and fertility alterations.

  Pharmacology, biochemistry, and behavior 20050801

• Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants.

  Plant cell reports 20031201

• Absence of interceptive effect in rats treated with Solanum lycocarpum (St. Hil).

  Contraception 20010101