20537-88-6 | Amifostine

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$57.00	$40.00
10mg	98%	in stock	$73.00	$51.00
50mg	98%	in stock	$179.00	$125.00
100mg	98%	in stock	$302.00	$211.00
250mg	98%	in stock	$509.00	$356.00

Description

• Catalog Number: AB06110
• Chemical Name: Amifostine
• CAS Number: 20537-88-6
• Molecular Formula: C5H15N2O3PS
• Molecular Weight: 214.223
• MDL Number: MFCD00453866
• SMILES: NCCCNCCSP(=O)(O)O

Computed Properties

• Complexity: 152
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 7
• XLogP3: -4.5

Literature

• Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

  Chemical research in toxicology 20150518

• Pharmacological strategies to spare normal tissues from radiation damage: useless or overlooked therapeutics?

  Cancer metastasis reviews 20121201

• High glucose inhibits the aspirin-induced activation of the nitric oxide/cGMP/cGMP-dependent protein kinase pathway and does not affect the aspirin-induced inhibition of thromboxane synthesis in human platelets.

  Diabetes 20121101

• A phase II study of submandibular gland transfer prior to radiation for prevention of radiation-induced xerostomia in head-and-neck cancer (RTOG 0244).

  International journal of radiation oncology, biology, physics 20121001

• Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.

  Health physics 20121001

• Postoperative pelvic hypofractionated accelerated radiotherapy with cytoprotection (HypoARC) for high-risk or recurrent prostate cancer.

  Anticancer research 20121001

• Meta-analysis of the efficacy of amifostine in the prevention of cisplatin ototoxicity.

  Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 20121001

• [Effect of amifostine on locally advanced non-small cell lung cancer patients treated with radiotherapy: a meta-analysis of randomized controlled trials].

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20120920

• Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells.

  International journal of oncology 20120901

• [Esophageal toxicity of radiation therapy: clinical risk factors and management].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20120901

• Protective effect of recombinant protein SOD-TAT on radiation-induced lung injury in mice.

  Life sciences 20120821

• Survival after accidental extrahepatic distribution of Y90 microspheres to the mesentery during a radioembolization procedure.

  Cardiovascular and interventional radiology 20120801

• A phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy.

  International journal of radiation oncology, biology, physics 20120801

• Radioprotective effects of troxerutin against gamma irradiation in mice liver.

  International journal of radiation biology 20120801

• Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest.

  Human reproduction (Oxford, England) 20120801

• The effects of heparan sulphate mimetic RGTA-OTR4120 on irradiated murine salivary glands.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120701

• ROS-scavenger and radioprotective efficacy of the new PrC-210 aminothiol.

  Radiation research 20120701

• Radiation-induced chronic oxidative renal damage can be reduced by amifostine.

  Medical oncology (Northwood, London, England) 20120601

• Medical interventions for the prevention of platinum-induced hearing loss in children with cancer.

  The Cochrane database of systematic reviews 20120516

• Effects of amifostine in combination with cyclophosphamide on female reproductive system.

  Reproductive sciences (Thousand Oaks, Calif.) 20120501

• Reduction of renal uptake of radiolabeled octreotate by amifostine coadministration.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120501

• Low-dose antioxidant is sufficient to regulate pulmonary redox equilibration.

  Critical care medicine 20120501

• Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis.

  PLoS neglected tropical diseases 20120501

• Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: an FTIR microspectroscopic imaging study.

  Archives of biochemistry and biophysics 20120415

• Radiation damage and radioprotectants: new concepts in the era of molecular medicine.

  The British journal of radiology 20120401

• A new orally active, aminothiol radioprotector-free of nausea and hypotension side effects at its highest radioprotective doses.

  International journal of radiation oncology, biology, physics 20120401

• Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection.

  Plastic and reconstructive surgery 20120401

• Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.

  Plastic and reconstructive surgery 20120401

• Swallowing dysfunction in cancer patients.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120301

• Local hemodynamic effects of radiation on the rabbit orbitozygomatic complex with and without cytoprotection.

  Plastic and reconstructive surgery 20120301

• Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group.

  International journal of radiation oncology, biology, physics 20120101

• Fukushima Daiichi Nuclear Power Plant accident: facts, environmental contamination, possible biological effects, and countermeasures.

  Journal of clinical biochemistry and nutrition 20120101

• Chemotherapy-induced neurotoxicity: the value of neuroprotective strategies.

  The Netherlands journal of medicine 20120101

• Radiation produces irreversible chronic dysfunction in the submandibular glands of the rat.

  The open dentistry journal 20120101

• Protective effect of polysaccharide-protein complex from a polypore mushroom, Phellinus rimosus against radiation-induced oxidative stress.

  Redox report : communications in free radical research 20120101

• Analgesic activity and safety of ash of silver used in Indian system of medicine in mice: a reverse pharmacological study.

  Indian journal of pharmacology 20120101

• Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats.

  Indian journal of pharmacology 20120101

• Radiochemoimmunotherapy with intensity-modulated concomitant boost: interim analysis of the REACH trial.

  Radiation oncology (London, England) 20120101

• Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).

  PloS one 20120101

• Healthcare costs and workloss burden of patients with chemotherapy-associated peripheral neuropathy in breast, ovarian, head and neck, and nonsmall cell lung cancer.

  Chemotherapy research and practice 20120101

• Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats.

  Indian journal of pharmacology 20120101

• Induction of oxidative stress in kidney.

  International journal of nephrology 20120101

• CyberKnife Boost for Patients with Cervical Cancer Unable to Undergo Brachytherapy.

  Frontiers in oncology 20120101

• A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation.

  International journal of nanomedicine 20120101

• The histopathological comparison of L-carnitine with amifostine for protective efficacy on radiation-induced acute small intestinal toxicity.

  Journal of cancer research and therapeutics 20120101

• The effect of amifostine on submandibular gland histology after radiation.

  International journal of otolaryngology 20120101

• Addition of amifostine to the CHOP regimen in elderly patients with aggressive non-Hodgkin lymphoma: a phase II trial showing reduction in toxicity without altering long-term survival.

  Hematology/oncology and stem cell therapy 20120101

• A phase II study of amifostine in children with myelodysplastic syndrome: a report from the Children's Oncology Group study (AAML0121).

  Pediatric blood & cancer 20111215

• Myelodysplastic syndrome in children: changing definitions from FAB 1976 to WHO 2008 classification systems.

  Pediatric blood & cancer 20111215

• Concurrent administration of liposomal doxorubicin improves the survival of patients with invasive bladder cancer undergoing hypofractionated accelerated radiotherapy (HypoARC).

  Medical oncology (Northwood, London, England) 20111201

• Protective effect of L-carnitine versus amifostine against cisplatin-induced nephrotoxicity in rats.

  Medical oncology (Northwood, London, England) 20111201

• Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma.

  Head & neck 20111201

• Protective role of tea polyphenols in combination against radiation-induced haematopoietic and biochemical alterations in mice.

  Phytotherapy research : PTR 20111201

• Preparation of amifostine polylactide-co-glycolide microspheres and its irradiation protective to mouse through oral administration.

  Drug development and industrial pharmacy 20111201

• Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury.

  Critical care medicine 20111201

• Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure.

  Cancer biotherapy & radiopharmaceuticals 20111201

• Central role of oxidative stress and its signaling pathways in causing and preventing acute lung injury.

  Critical care medicine 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.

  Free radical biology & medicine 20111115

• Attenuation of sulfur mustard toxicity by S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) in mouse liver.

  Toxicology mechanisms and methods 20111001

• Extended-field irradiation and intracavitary brachytherapy combined with cisplatin and amifostine for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of arm II of Radiation Therapy Oncology Group (RTOG) 0116.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20111001

• Antioxidant prophylaxis for cellular injury in ovarian surface epithelium resulting from CO₂ pneumoperitoneum in a laparoscopic rat model.

  Archives of gynecology and obstetrics 20110901

• Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip.

  Biofabrication 20110901

• Cytotoxicity of gamma-ray in rat immature hippocampal neurons.

  Journal of veterinary science 20110901

• Severe allergic reactions to thiol-based cytoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor.

  Journal of pediatric hematology/oncology 20110801

• A Phase I trial: dose escalation of melphalan in the 'BEAM' regimen using amifostine cytoprotection.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110701

• Effects of potential dietary inhibitors of endogenous DNA damage on mutagenesis and lipid peroxidation in lacZ mice.

  Environmental and molecular mutagenesis 20110701

• Chemical genoprotection: reducing biological damage to as low as reasonably achievable levels.

  Dento maxillo facial radiology 20110701

• Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110620

• Cardioprotective interventions for cancer patients receiving anthracyclines.

  The Cochrane database of systematic reviews 20110615

• Bevacizumab, capecitabine, amifostine, and preoperative hypofractionated accelerated radiotherapy (HypoArc) for rectal cancer: a Phase II study.

  International journal of radiation oncology, biology, physics 20110601

• Amifostine-related fever-rash during fractionated radiotherapy: diagnostic and predictive role of C-reactive protein.

  American journal of clinical oncology 20110601

• [Prediction and bioinformatics analysis of human gene expression profiling regulated by amifostine].

  Zhongguo shi yan xue ye xue za zhi 20110601

• Risk of xerostomia in association with the receipt of radiation therapy in older patients with head and neck cancer.

  American journal of therapeutics 20110501

• Phosphorylation and cytoplasmic localization of MAPK p38 during apoptosis signaling in bone marrow granulocytes of mice irradiated in vivo and the role of amifostine in reducing these effects.

  Acta histochemica 20110501

• Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?

  European journal of clinical pharmacology 20110501

• Treatment of low-risk prostate cancer with radical hypofractionated accelerated radiotherapy with cytoprotection (HypoARC): an interim analysis of toxicity and efficacy.

  Anticancer research 20110501

• Interventions for preventing oral mucositis for patients with cancer receiving treatment.

  The Cochrane database of systematic reviews 20110413

• Screening of protective effect of amifostine on radiation-induced structural and functional variations in rat liver microsomal membranes by FT-IR spectroscopy.

  Analytical chemistry 20110401

• Administration of rat acute-phase protein α(2)-macroglobulin before total-body irradiation initiates cytoprotective mechanisms in the liver.

  Radiation and environmental biophysics 20110301

• Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants.

  AJR. American journal of roentgenology 20110301

• Cardioprotective effects of Glycyrrhiza uralensis extract against doxorubicin-induced toxicity.

  International journal of toxicology 20110301

• The Children's Oncology Group routinely applies 'lack of efficacy' interim monitoring to its randomized clinical trials.

  The American journal of bioethics : AJOB 20110301

• Interventions for preventing neuropathy caused by cisplatin and related compounds.

  The Cochrane database of systematic reviews 20110216

• Role of capsaicin-sensitive primary afferent neurons and non-protein sulphydryl groups on gastroprotective effect of amifostine against ethanol-induced gastric damage in rats.

  Digestive diseases and sciences 20110201

• Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.

  The Lancet. Oncology 20110201

• Amifostine in the treatment of head and neck cancer: intravenous administration, subcutaneous administration, or none of the above.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110

• Subcutaneous compared with intravenous administration of amifostine in patients with head and neck cancer receiving radiotherapy: final results of the GORTEC2000-02 phase III randomized trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110

• Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine.

  Biochemical and biophysical research communications 20110107

• REC-2006-A Fractionated Extract of Podophyllum hexandrum Protects Cellular DNA from Radiation-Induced Damage by Reducing the Initial Damage and Enhancing Its Repair In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Efficacy of amifostine in treating patients with idiopathic thrombocytopenia purpura.

  Cell biochemistry and biophysics 20110101

• Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.

  Genome integrity 20110101

• Role of amifostine on acute and late radiation nephrotoxicity: a histopathological study.

  In vivo (Athens, Greece) 20110101

• Narrow amifostine dose windows define radioprotection outcome, following fractionated whole-body irradiation of mice.

  In vivo (Athens, Greece) 20110101

• Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model.

  Sarcoma 20110101

• Transport processes of radiopharmaceuticals and -modulators.

  Radiation oncology (London, England) 20110101

• N-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.

  PloS one 20110101

• Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice.

  BMC cancer 20110101

• Acute radiation effect in the brain in infant rats: Neurocognitive and histopathological examination.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

• Civilian nuclear incidents: An overview of historical, medical, and scientific aspects.

  Journal of emergencies, trauma, and shock 20110101

• Role of systemic peri-operative chemotherapy in management of transitional cell carcinoma of bladder.

  Indian journal of urology : IJU : journal of the Urological Society of India 20110101

• Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis.

  Journal of translational medicine 20110101

• Induction chemotherapy with paclitaxel and cisplatin to concurrent radiotherapy and weekly paclitaxel in the treatment of loco-regionally advanced, stage IV (M0), head and neck squamous cell carcinoma. Mature results of a prospective study.

  Radiation oncology (London, England) 20110101

• Radiation proctitis: current strategies in management.

  Gastroenterology research and practice 20110101

• Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes.

  International journal of molecular sciences 20110101

• Radiotherapy and 'new' drugs-new side effects?

  Radiation oncology (London, England) 20110101

• Oxaliplatin-induced neuropathy in colorectal cancer.

  Journal of oncology 20110101

• Endometrial cancer patients: a cohort previous to changes in tumour behaviour and treatment strategies.

  ISRN obstetrics and gynecology 20110101

• N-acetylcysteine ameliorates γ-radiation-induced deterioration of bone quality in the rat femur.

  The Journal of international medical research 20110101

• The prospective role of plant products in radiotherapy of cancer: a current overview.

  Frontiers in pharmacology 20110101

• Neurotoxicity caused by the treatment with platinum analogues.

  Chemotherapy research and practice 20110101

• Phase I study of celecoxib with concurrent irinotecan, Cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer.

  Frontiers in oncology 20110101

• Cell death signaling and anticancer therapy.

  Frontiers in oncology 20110101

• Strategies for discovery of small molecule radiation protectors and radiation mitigators.

  Frontiers in oncology 20110101

• Interventions for preventing oral mucositis for patients with cancer receiving treatment.

  The Cochrane database of systematic reviews 20101208

• Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma.

  International journal of radiation oncology, biology, physics 20101201

• Renoprotective potency of amifostine in rat renal ischaemia-reperfusion.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101201

• Yeast DEL assay detects protection against radiation-induced cytotoxicity and genotoxicity: adaptation of a microtiter plate version.

  Radiation research 20101201

• Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent.

  International journal of oncology 20101101

• Mechanisms of Cisplatin nephrotoxicity.

  Toxins 20101101

• Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice.

  Cancer chemotherapy and pharmacology 20101001

• [Application of Cochrane systematic reviews in diagnosis and treatment for oral mucosal diseases].

  Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20101001

• Crystal structure of Staphylococcus aureus metallopeptidase (Sapep) reveals large domain motions between the manganese-bound and apo-states.

  The Journal of biological chemistry 20100917

• Drde-07: a possible antidote for sulphur mustard toxicity.

  Cellular and molecular biology (Noisy-le-Grand, France) 20100911

• Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit.

  Human & experimental toxicology 20100901

• Intracavitary cisplatin therapy for pediatric malignancies.

  Pediatric blood & cancer 20100901

• Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.

  Radiation research 20100901

• The rat acute-phase protein α2-macroglobulin plays a central role in amifostine-mediated radioprotection.

  Journal of radiological protection : official journal of the Society for Radiological Protection 20100901

• Does amifostine have radioprotective effects on salivary glands in high-dose radioactive iodine-treated differentiated thyroid cancer.

  European journal of nuclear medicine and molecular imaging 20100801

• A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20100801

• A systematic review of dental disease in patients undergoing cancer therapy.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20100801

• A systematic review of dysgeusia induced by cancer therapies.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20100801

• Dendro[C(60)]fullerene DF-1 provides radioprotection to radiosensitive mammalian cells.

  Radiation and environmental biophysics 20100801

• Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature.

  Current oncology (Toronto, Ont.) 20100801

• Comparative toxic effect of nitrogen mustards (HN-1, HN-2, and HN-3) and sulfur mustard on hematological and biochemical variables and their protection by DRDE-07 and its analogues.

  International journal of toxicology 20100701

• Systemic chemotherapy-induced microsatellite instability in the mononuclear cell fraction of women with breast cancer can be reproduced in vitro and abrogated by amifostine.

  The Journal of pharmacy and pharmacology 20100701

• Prophylactic efficacy of combination of DRDE-07 and its analogues with amifostine against sulphur mustard induced systemic toxicity.

  Indian journal of experimental biology 20100701

• Radioprotection from radiation-induced lymphedema without tumor protection.

  Lymphology 20100601

• Radiochemotherapy with cetuximab, cisplatin, and amifostine for locally advanced head and neck cancer: a feasibility study.

  International journal of radiation oncology, biology, physics 20100501

• Kidney protection during peptide receptor radionuclide therapy with somatostatin analogues.

  European journal of nuclear medicine and molecular imaging 20100501

• Combined treatment with cytoprotective agents and radiotherapy.

  Cancer treatment reviews 20100501

• Supportive care in head and neck oncology.

  Current opinion in oncology 20100501

• [Drug delivery of CPC/amifostine/cisplatin complex in vitro and its ability in repairing bone defect and eliminating tumor in vivo].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100501

• Amifostine protection against induced DNA damage in gamma-irradiated Escherichia coli cells depend on recN DNA repair gene product activity.

  Environmental toxicology 20100401

• Radioprotectors and mitigators of radiation-induced normal tissue injury.

  The oncologist 20100401

• [In vitro study on physical and chemical properities of calcium phosphate cement/amifostine complex and on vitality of cultured cells].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20100401

• Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients.

  Radiation and environmental biophysics 20100301

• Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation.

  Journal of veterinary science 20100301

• The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.

  The West Indian medical journal 20100301

• Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.

  Radiation research 20100201

• Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100201

• Analgesic and anti-inflammatory activity of amifostine, DRDE-07, and their analogs, in mice.

  Indian journal of pharmacology 20100201

• Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro.

  Oncology reports 20100101

• Amifostine reduces the seminiferous epithelium damage in doxorubicin-treated prepubertal rats without improving the fertility status.

  Reproductive biology and endocrinology : RB&E 20100101

• Prediction of clinical toxicity in locally advanced head and neck cancer patients by radio-induced apoptosis in peripheral blood lymphocytes (PBLs).

  Radiation oncology (London, England) 20100101

• [Physicochemical and sustained drug release properties of calcium phosphate cement/amifostine/cisplatin complex and its effect in repairing bone defect due to tumor resection in rabbits].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100101

• Stereotactic body radiotherapy for organ-confined prostate cancer.

  BMC urology 20100101

• TNF-alpha regulates the effects of irradiation in the mouse bone marrow microenvironment.

  PloS one 20100101

• Systemic lymphadenectomy cannot be recommended for low-risk corpus cancer.

  Obstetrics and gynecology international 20100101

• Optimization of DNA delivery by three classes of hybrid nanoparticle/DNA complexes.

  Journal of nanobiotechnology 20100101

• Cytokines levels, severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer--a prospective pilot study.

  Radiation oncology (London, England) 20100101

• The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A.

  BMC medicine 20100101

• MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients.

  BMC medical genomics 20100101

• Evaluation of the fullerene compound DF-1 as a radiation protector.

  Radiation oncology (London, England) 20100101

• Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy.

  Radiation oncology (London, England) 20100101

• Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis.

  Journal of experimental & clinical cancer research : CR 20100101

• Holmium-166 radioembolization for the treatment of patients with liver metastases: design of the phase I HEPAR trial.

  Journal of experimental & clinical cancer research : CR 20100101

• Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials.

  BMC cancer 20100101

• Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model.

  In vivo (Athens, Greece) 20100101

• Long term chemoradiotherapy-related dental and skeletal complications in a young female with nasopharyngeal carcinoma.

  International journal of general medicine 20100101

• Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration.

  BMC cancer 20100101

• Amifostine modulates radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients.

  Journal of radiation research 20100101

• Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: an in vitro and in vivo assessment.

  Oxidative medicine and cellular longevity 20100101

• In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells.

  BMC cancer 20100101

• Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated.

  Molecular cancer 20100101

• The PI3K/Akt pathway upregulates Id1 and integrin α4 to enhance recruitment of human ovarian cancer endothelial progenitor cells.

  BMC cancer 20100101

• Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

  PloS one 20100101

• Hemorrhagic cystitis: A challenge to the urologist.

  Indian journal of urology : IJU : journal of the Urological Society of India 20100101

• The preventive effect of N-acetylcysteine on radiation-induced dermatitis in a rat model.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20100101

• Comparison of protective effects of L-carnitine and amifostine on radiation-induced toxicity to growing bone: histopathology and scintigraphy findings.

  Asian Pacific journal of cancer prevention : APJCP 20100101

• Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress.

  Oxidative medicine and cellular longevity 20100101

• Oral microbiota and cancer.

  Journal of oral microbiology 20100101

• The role of dentist in palliative care team.

  Indian journal of palliative care 20100101

• Medical radiation countermeasures for nuclear and radiological emergencies: Current status and future perspectives.

  Journal of pharmacy & bioallied sciences 20100101

• The protective effect of amifostine on ultraviolet B-exposed xeroderma pigmentosum mice.

  Ecancermedicalscience 20100101

• Myelodysplastic syndromes/neoplasms: recent classification system based on World Health Organization Classification of Tumors - International Agency for Research on Cancer for Hematopoietic and Lymphoid Tissues.

  Journal of blood medicine 20100101

• Prevention and management of antineoplastic therapy induced oral mucositis.

  National journal of maxillofacial surgery 20100101

• Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group.

  Cancer 20091215

• Hepatoblastoma, cisplatin, and ototoxicity: good news on deaf ears.

  Cancer 20091215

• The role of amifostine on late normal tissue damage induced by pelvic radiotherapy with concomitant gemcitabine: an in vivo study.

  Medical oncology (Northwood, London, England) 20091201

• Quality of life supersedes the classic prognosticators for long-term survival in locally advanced non-small-cell lung cancer: an analysis of RTOG 9801.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091201

• [Mechanism and problem of amifostine in treating myelodysplastic syndromes].

  Zhongguo shi yan xue ye xue za zhi 20091201

• A prospective study of salivary gland function in lymphoma patients receiving head and neck irradiation.

  International journal of radiation oncology, biology, physics 20091115

• Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091115

• Longitudinal oncology registry of head and neck carcinoma (LORHAN): initial supportive care findings.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20091101

• Amifostine for salivary glands in high-dose radioactive iodine treated differentiated thyroid cancer.

  The Cochrane database of systematic reviews 20091007

• Cytoprotective activity of amifostine on cultured human lymphocytes exposed to irinotecan.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001

• Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer.

  Cancer 20091001

• Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis.

  Free radical biology & medicine 20090915

• Amifostine has the potential to induce haematologic responses and decelerate disease progression in individual patients with low- and intermediate-1-risk myelodysplastic syndromes.

  Leukemia research 20090901

• Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.

  Molecular cancer therapeutics 20090901

• The role of apoptotic cell death in the radiosensitising effect of gemcitabine.

  British journal of cancer 20090818

• Development of a photosensitive, high-throughput chip-based superoxide dismutase (SOD) assay to explore the radioprotective activity of herbal plants.

  Biosensors & bioelectronics 20090815

• DRDE-07 and its analogues as promising cytoprotectants to nitrogen mustard (HN-2)--an alkylating anticancer and chemical warfare agent.

  Toxicology letters 20090810

• Radioprotective effect of moderate wine consumption in patients with breast carcinoma.

  International journal of radiation oncology, biology, physics 20090801

• Extrapleural pneumonectomy followed by intracavitary intraoperative hyperthermic cisplatin with pharmacologic cytoprotection for treatment of malignant pleural mesothelioma: a phase II prospective study.

  The Journal of thoracic and cardiovascular surgery 20090801

• Hypofractionated and accelerated radiotherapy with subcutaneous amifostine cytoprotection as short adjuvant regimen after breast-conserving surgery: interim report.

  International journal of radiation oncology, biology, physics 20090715

• Differential effect triggered by a heparan mimetic of the RGTA family preventing oral mucositis without tumor protection.

  International journal of radiation oncology, biology, physics 20090715

• [Application of bioinformatics analysis to optimize amifostine combination therapeutic regimen of myelodysplastic syndrome].

  Zhonghua yi xue za zhi 20090714

• Cytoprotective effects of amifostine in the treatment of childhood malignancies.

  Pediatric blood & cancer 20090701

• Radiation technique influence on percutaneous endoscopic gastrostomy tube dependence: Comparison between two radiation schemes.

  Head & neck 20090701

• WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.

  Environmental and molecular mutagenesis 20090701

• Protective effects of amifostine and cyclooxygenase-1 inhibitor against normal human epidermal keratinocyte toxicity induced by methotrexate and 5-fluorouracil.

  Basic & clinical pharmacology & toxicology 20090701

• History and development of radiation-protective agents.

  International journal of radiation biology 20090701

• The radioprotective effect of alpha2-macroglobulin: a morphological study of rat liver.

  Medical science monitor : international medical journal of experimental and clinical research 20090701

• The acute-phase protein alpha2-macroglobulin plays an important role in radioprotection in the rat.

  Shock (Augusta, Ga.) 20090601

• Computed tomography assessment of lung density in patients with lung cancer treated with accelerated hypofractionated radio-chemotherapy supported with amifostine.

  American journal of clinical oncology 20090601

• Treatment of head and neck cancers: issues for clinical pharmacists.

  Pharmacotherapy 20090501

• Histopathological and scintigraphic comparisons of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats.

  Clinical and experimental pharmacology & physiology 20090501

• Evaluation of new thiadiazoles and benzothiazoles as potential radioprotectors: free radical scavenging activity in vitro and theoretical studies (QSAR, DFT).

  Free radical biology & medicine 20090415

• An outpatient intraperitoneal chemotherapy regimen for advanced ovarian cancer.

  Gynecologic oncology 20090401

• Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice.

  Saudi medical journal 20090401

• Amifostine reduces lung vascular permeability via suppression of inflammatory signalling.

  The European respiratory journal 20090301

• Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response.

  International journal of radiation oncology, biology, physics 20090301

• The role of amifostine in the treatment of head and neck cancer with cisplatin-radiotherapy.

  European journal of cancer care 20090301

• Comparative reaction rates of various antioxidants with ABTS radical cation.

  Journal of agricultural and food chemistry 20090225

• Radioprotection of osteoblasts by a fractionated dose regimen and amifostine.

  Plastic and reconstructive surgery 20090201

• A phase I study of extrapleural pneumonectomy and intracavitary intraoperative hyperthermic cisplatin with amifostine cytoprotection for malignant pleural mesothelioma.

  The Journal of thoracic and cardiovascular surgery 20090201

• Effects of amifostine administration prior to irradiation to the submandibular gland in mice: autoradiographic study using 3H-leucine.

  Okajimas folia anatomica Japonica 20090201

• Prevention of hearing loss in children receiving cisplatin chemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090110

• American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090101

• Strategies for managing radiation-induced mucositis in head and neck cancer.

  Seminars in radiation oncology 20090101

• Amifostine enhances recovery and expansion of peripheral FAS/CD95+ T- and NK-cell subpopulations during radiotherapy of patients with head-neck cancer.

  International journal of radiation biology 20090101

• Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome.

  Journal of hematology & oncology 20090101

• p53-Induced apoptosis and inhibitors of p53.

  Current medicinal chemistry 20090101

• A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China.

  Journal of hematology & oncology 20090101

• Evaluation of the possible benefits of post-radiotherapy surgery after concomitant chemoradiotherapy with a new radio-sensitizing regimen (irinotecan / CPT-11, interferon A2b and amifostine) for advanced-stage cervical carcinoma. Preliminary results of a pilot phase-II study.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20090101

• Antimutagenicity of amifostine against the anticancer drug fotemustine in the Drosophila somatic mutation and recombination (SMART) test.

  Mutation research 20090101

• Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomia.

  Radiation oncology (London, England) 20090101

• Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits.

  Journal of cardiothoracic surgery 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• Amifostine (WR2721) confers DNA protection to in vivo cisplatin-treated murine peripheral blood leukocytes.

  Dose-response : a publication of International Hormesis Society 20090101

• Auditory late effects of chemotherapy.

  Cancer treatment and research 20090101

• Postoperative accelerated radiotherapy with cytoprotection followed by three-dimensional conformal boost in patients with early endometrial/cervical cancer.

  Tumori 20090101

• Protective effect of melatonin against mitomycin C-induced genotoxic damage in peripheral blood of rats.

  Journal of biomedicine & biotechnology 20090101

• Analysis of the cytoprotective effect of amifostine on the irradiated inner ear of guinea pigs: an experimental study.

  Brazilian journal of otorhinolaryngology 20090101

• Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo.

  AIDS research and therapy 20090101

• Cisplatin overdose: toxicities and management.

  Drug safety 20090101

• Biomedical applications of functionalized fullerene-based nanomaterials.

  International journal of nanomedicine 20090101

• Radiation induced oral mucositis.

  Indian journal of palliative care 20090101

• WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.

  Free radical biology & medicine 20081215

• Clinically meaningful differences in patient-reported outcomes with amifostine in combination with chemoradiation for locally advanced non-small-cell lung cancer: an analysis of RTOG 9801.

  International journal of radiation oncology, biology, physics 20081201

• Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity.

  Journal of veterinary science 20081201

• Inhalative exposure to vanadium pentoxide causes DNA damage in workers: results of a multiple end point study.

  Environmental health perspectives 20081201

• The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model.

  Acta medica Okayama 20081201

• Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents.

  International journal of nanomedicine 20081201

• Inhibition of HIF-1alpha by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo.

  British journal of cancer 20081104

• The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20081101

• Radioprotection in mice following oral administration of WR-1065/PLGA nanoparticles.

  International journal of radiation biology 20081101

• Randomized phase 2 study of subcutaneous amifostine versus epoetin-alpha given 3 times weekly during concurrent chemotherapy and hyperfractionated radiotherapy for limited-disease small cell lung cancer.

  Cancer 20081001

• The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20081001

• RLIP76 in defense of radiation poisoning.

  International journal of radiation oncology, biology, physics 20081001

• Pharmacologic normal tissue protection in clinical radiation oncology: focus on amifostine.

  Expert opinion on drug metabolism & toxicology 20081001

• Approaches to the prevention and management of radiation colitis.

  Current gastroenterology reports 20081001

• Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells.

  Plastic and reconstructive surgery 20081001

• [Prophylactic effect of amifostine on oxaliplatin-related neurotoxicity in patients with digestive tract tumors].

  Ai zheng = Aizheng = Chinese journal of cancer 20081001

• Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.

  Hematology (Amsterdam, Netherlands) 20081001

• [Short-term curative effect of amifostine combined with rhbeta-EPO on patients with pure erythroid aplasia].

  Zhongguo shi yan xue ye xue za zhi 20081001

• Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.

  PLoS genetics 20081001

• Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury.

  International journal of radiation biology 20081001

• Miscellaneous.

  Indian journal of pharmacology 20081001

• Emerging drugs for chemotherapy-induced mucositis.

  Expert opinion on emerging drugs 20080901

• Amifostine protection against mitomycin-induced chromosomal breakage in fanconi anaemia lymphocytes.

  Molecules (Basel, Switzerland) 20080821

• Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine.

  International journal of radiation biology 20080801

• Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080801

• Directed evolution of a biterminal bacterial display scaffold enhances the display of diverse peptides.

  Protein engineering, design & selection : PEDS 20080701

• Amifostine protective effect on cisplatin-treated rat testis.

  Anatomical record (Hoboken, N.J. : 2007) 20080701

• Alternate delivery route for amifostine as a radio-/chemo-protecting agent.

  The Journal of pharmacy and pharmacology 20080701

• Pharmacological agents for the prevention and treatment of toxic radiation exposure in spaceflight.

  Aviation, space, and environmental medicine 20080701

• Amifostine use in radiation-induced kidney damage. Preclinical evaluation with scintigraphic and histopathologic parameters.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20080701

• Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo.

  Environmental toxicology and pharmacology 20080701

• Amifostine prior to lethal irradiation prevents allogeneic bone marrow engraftment in mice.

  Bone marrow transplantation 20080601

• Wound healing in radiated skin: pathophysiology and treatment options.

  International wound journal 20080601

• Prevention and treatment of regimen-related mucosal toxicity.

  Recent patents on anti-cancer drug discovery 20080601

• Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard.

  Indian journal of pharmacology 20080601

• Factors associated with radiation-induced nausea and vomiting in head and neck cancer patients treated with intensity modulated radiation therapy.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20080501

• Stevens-Johnson syndrome and toxic epidermal necrolysis induced by amifostine during head and neck radiotherapy.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20080501

• Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine.

  Radiation research 20080501

• Cytoprotective efficacy of amifostine against radiation- induced rectal toxicity: objective and subjective grading scales for radiomucositis.

  Molecules (Basel, Switzerland) 20080418

• Resistance to the nitric oxide/cyclic guanosine 5'-monophosphate/protein kinase G pathway in vascular smooth muscle cells from the obese Zucker rat, a classical animal model of insulin resistance: role of oxidative stress.

  Endocrinology 20080401

• In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro.

  Pediatric nephrology (Berlin, Germany) 20080401

• [Amifostine-induced Stevens-Johnson syndrome during radiotherapy].

  Annales de dermatologie et de venereologie 20080401

• 5,7-Dihydroxychromone-2-carboxylic acid and it's transition-metal (Mn and Zn) chelates as non-thiol radioprotective agents.

  European journal of medicinal chemistry 20080301

• Preparation of polylactide-co-glycolide and chitosan hybrid microcapsules of amifostine using coaxial ultrasonic atomizer with solvent evaporation.

  The Journal of pharmacy and pharmacology 20080301

• Cytogenetic damage induced by radiotherapy. Evaluation of protection by amifostine and analysis of chromosome aberrations persistence.

  International journal of radiation biology 20080301

• Radiation-induced craniofacial bone growth inhibition: in vitro cytoprotection in the rabbit orbitozygomatic complex periosteum-derived cell culture.

  Plastic and reconstructive surgery 20080301

• Limited cytoprotective effects of amifostine in high-dose radioactive iodine 131-treated well-differentiated thyroid cancer patients: analysis of quantitative salivary scan.

  Thyroid : official journal of the American Thyroid Association 20080301

• A pilot study of addition of amifostine to melphalan, carboplatin, etoposide, and cyclophosphamide with autologous hematopoietic stem cell transplantation in pediatric solid tumors-A pediatric blood and marrow transplant consortium study.

  Journal of pediatric hematology/oncology 20080301

• Amifostine can differentially modulate DNA double-strand breaks and apoptosis induced by idarubicin in normal and cancer cells.

  Experimental oncology 20080301

• Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast.

  Oncogene 20080221

• Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase.

  Cancer letters 20080218

• Regulation of CD20 expression by radiation-induced changes in intracellular redox status.

  Free radical biology & medicine 20080215

• [Painful hyperexcitability syndrome with oxaliplatin containing chemotherapy. Clinical features, pathophysiology and therapeutic options].

  Schmerz (Berlin, Germany) 20080201

• Protective effect of saponins from Panax notoginseng against doxorubicin-induced cardiotoxicity in mice.

  Planta medica 20080201

• [Therapy of 17 cases of idiopathic thrombocytopenia purpura by amifostine].

  Zhongguo shi yan xue ye xue za zhi 20080201

• Hypoxia inducible factor (HIf1alpha and HIF2alpha) and carbonic anhydrase 9 (CA9) expression and response of head-neck cancer to hypofractionated and accelerated radiotherapy.

  International journal of radiation biology 20080101

• Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score.

  International journal of radiation oncology, biology, physics 20080101

• Cytoprotection for radiation-associated normal tissue injury.

  Cancer treatment and research 20080101

• The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias.

  BMC medical research methodology 20080101

• Hypofractionated/accelerated radiotherapy with cytoprotection (HypoARC) combined with vinorelbine and liposomal doxorubicin for locally advanced non-small cell lung cancer (NSCLC).

  Anticancer research 20080101

• A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores.

  BMC pharmacology 20080101

• Prevention of radiochemotherapy-induced toxicity with amifostine in patients with malignant orbital tumors involving the lacrimal gland: a pilot study.

  Radiation oncology (London, England) 20080101

• Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study.

  Anticancer research 20080101

• New pathways for alimentary mucositis.

  Journal of oncology 20080101

• Effect of dexrazoxane and amifostine on the vertebral bone quality of Doxorubicin treated male rats.

  The open orthopaedics journal 20080101

• TAK1 mRNA expression in the tumor tissue of locally advanced head and neck cancer patients.

  Gene regulation and systems biology 20080101

• A unique complication associated with concurrent chemoradiation for the treatment of locally advanced head and neck cancer.

  Clinical medicine. Oncology 20080101

• Efficacy and safety of subcutaneous amifostine in minimizing radiation-induced toxicities in patients receiving combined-modality treatment for squamous cell carcinoma of the head and neck.

  International journal of radiation oncology, biology, physics 20071201

• In regard to Münter et Al. Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without amifostine. (Int j radiat oncol biol phys 2007;67:651-659).

  International journal of radiation oncology, biology, physics 20071201

• Effects of dexrazoxane and amifostine on evolution of Doxorubicin cardiomyopathy in vivo.

  Experimental biology and medicine (Maywood, N.J.) 20071201

• Interventions for preventing oral mucositis for patients with cancer receiving treatment.

  The Cochrane database of systematic reviews 20071017

• Mechanisms of cisplatin ototoxicity and progress in otoprotection.

  Current opinion in otolaryngology & head and neck surgery 20071001

• Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents.

  International journal of radiation oncology, biology, physics 20071001

• Paclitaxel, carboplatin, 5-fluorouracil, and radiation for locally advanced esophageal cancer: phase II results of preliminary pharmacologic and molecular efforts to mitigate toxicity and predict outcomes: North Central Cancer Treatment Group (N0044).

  American journal of clinical oncology 20071001

• Trends in the development of radioprotective agents.

  Drug discovery today 20071001

• [Curative efficacy of fludarabine combined with rituximab and amifostine on aged patient with B-chronic lymphocytic leukemia].

  Zhongguo shi yan xue ye xue za zhi 20071001

• Pharmacologic approaches to radiation protection.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070910

• Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20070901

• In regards to Münter et Al. (Int J Radiat Oncol Biol Phys 2007;67:651-659).

  International journal of radiation oncology, biology, physics 20070901

• Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin.

  Pediatric hematology and oncology 20070901

• Do antioxidants interfere with radiation therapy for cancer?

  Integrative cancer therapies 20070901

• Radioprotection of craniofacial bone growth.

  The Journal of craniofacial surgery 20070901

• Zebrafish as a model system to screen radiation modifiers.

  Current genomics 20070901

• Cytoprotective agents used in the treatment of patients with cancer.

  Seminars in oncology nursing 20070801

• Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of ARM 1 of RTOG 0116.

  International journal of radiation oncology, biology, physics 20070715

• Tissue-protective effects of fullerenol C60(OH)24 and amifostine in irradiated rats.

  Colloids and surfaces. B, Biointerfaces 20070701

• Is it possible to predict renal function in small animals using a multi-pinhole SPECT system.

  European journal of nuclear medicine and molecular imaging 20070701

• A new intensive induction schedule, including high-dose Idarubicin, high-dose Aracytin and Amifostine, in older AML patients: feasibility and long-term results in 42 patients.

  Experimental hematology 20070701

• The DNA-damaging potential of tamoxifen in breast cancer and normal cells.

  Archives of toxicology 20070701

• Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs.

  Radiation research 20070701

• Amifostine: the first selective-target and broad-spectrum radioprotector.

  The oncologist 20070601

• Toxic epidermal necrolysis.

  Clinical journal of oncology nursing 20070601

• Daily subcutaneous amifostine administration during irradiation of pediatric head and neck cancers.

  Pediatric blood & cancer 20070501

• Amifostine protects rat kidneys during peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate.

  European journal of nuclear medicine and molecular imaging 20070501

• Effect of amifostine on response rates in locally advanced non-small-cell lung cancer patients treated on randomized controlled trials: a meta-analysis.

  International journal of radiation oncology, biology, physics 20070501

• Clinical trial design limitations in head and neck squamous cell carcinomas.

  Current opinion in oncology 20070501

• The role of saliva in oral health: strategies for prevention and management of xerostomia.

  The journal of supportive oncology 20070501

• Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha.

  Radiation research 20070401

• Cytotoxic treatment-induced gastrointestinal symptoms.

  Current opinion in supportive and palliative care 20070401

• A sequential procedure for monitoring clinical trials against historical controls.

  Statistics in medicine 20070330

• [Role of amifostine against the effect of etoposide on non-Hodgkin lymphoma bone marrow derived mesenchymal stem cells: an in vitro experiment].

  Zhonghua yi xue za zhi 20070327

• Phase I North Central Cancer Treatment Group Trial-N9923 of escalating doses of twice-daily thoracic radiation therapy with amifostine and with alternating chemotherapy in limited stage small-cell lung cancer.

  International journal of radiation oncology, biology, physics 20070315

• Ifosfamide toxicity in cultured proximal renal tubule cells.

  Pediatric nephrology (Berlin, Germany) 20070301

• Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine.

  International journal of radiation oncology, biology, physics 20070301

• Updated clinical practice guidelines for the prevention and treatment of mucositis.

  Cancer 20070301

• Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells.

  Journal of veterinary science 20070301

• Management of salivary hypofunction during and after radiotherapy.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301

• The effect of amifostine, a cytoprotective agent, on paraquat toxicity in mice.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070301

• cDNA microarray study to identify expression changes relevant for apoptosis in K562 cells co-treated with amifostine and imatinib.

  Cancer chemotherapy and pharmacology 20070201

• A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer.

  International journal of radiation oncology, biology, physics 20070201

• Radical hypofractionated accelerated radiotherapy with cytoprotection for invasive bladder cancer.

  Urology 20070201

• [Amifostine used in the treatment of patients with myelodysplastic syndrome].

  Zhongguo shi yan xue ye xue za zhi 20070201

• Interventions for preventing neuropathy caused by cisplatin and related compounds.

  The Cochrane database of systematic reviews 20070124

• Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis.

  Cancer chemotherapy and pharmacology 20070101

• Kojic acid and its manganese and zinc complexes as potential radioprotective agents.

  Bioorganic & medicinal chemistry letters 20070101

• Amifostine (Wr-2721) prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence.

  Digestive diseases and sciences 20070101

• Anaphylactoid reaction from amifostine.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20070101

• Radioprotective effects of hawthorn fruit extract against gamma irradiation in mouse bone marrow cells.

  Journal of radiation research 20070101

• The role of sulfur in platinum anticancer chemotherapy.

  Anti-cancer agents in medicinal chemistry 20070101

• Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1.

  Alternative therapies in health and medicine 20070101

• Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, Part 2.

  Alternative therapies in health and medicine 20070101

• Concurrent chemoradiotherapy with vinorelbine and a platinum compound followed by consolidation chemotherapy for unresectable stage III non-small cell lung cancer: preliminary results of a phase II study.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20070101

• Role of stem cells in cancer therapy and cancer stem cells: a review.

  Cancer cell international 20070101

• Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation.

  Radiation oncology (London, England) 20070101

• Influence of amifostine on late radiation-toxicity in head and neck cancer--a follow-up study.

  Anticancer research 20070101

• Amifostine protects bone marrow from benzene-induced hematotoxicity in mice.

  International journal of toxicology 20070101

• Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum.

  BMC cancer 20070101

• Hypofractionated accelerated radiochemotherapy with cytoprotection (Chemo-HypoARC) for inoperable non-small cell lung carcinoma.

  Anticancer research 20070101

• Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma.

  BMC cancer 20070101

• A case of Stevens-Johnson syndrome possibly induced by amifostine during radiotherapy.

  Tumori 20070101

• Use of amifostine in the treatment of recurrent solid tumours in children.

  Hippokratia 20070101

• Autologous stem cell transplantation beyond 60 years of age.

  Bone marrow transplantation 20061201

• Podophyllum hexandrum Offers Radioprotection by Modulating Free Radical Flux: Role of Aryl-Tetralin Lignans.

  Evidence-based complementary and alternative medicine : eCAM 20061201

• Effect of Amifostine to prevent radiotherapy-induced acute and late toxicity in head and neck cancer patients who had normal or mild impaired salivary gland function.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20061201

• Maximizing the delivery of intraperitoneal therapy while minimizing drug toxicity and maintaining quality of life.

  Seminars in oncology 20061201

• Recombinant human erythropoietin in comparison to amifostine against cisplatin-induced peripheral sensorial neurotoxicity in rats.

  Journal of experimental & clinical cancer research : CR 20061201

• Radioprotectants: adding quality of life to survivorship?

  Seminars in oncology nursing 20061101

• Amelioration of early radiation effects in oral mucosa (mouse) by intravenous or subcutaneous administration of amifostine.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20061001

• Computed tomography (CT) scan evaluation of late toxicity following hypofractionated/accelerated radiotherapy with cytoprotection (HypoARC) in breast cancer patients treated with conservative surgery.

  American journal of clinical oncology 20061001

• [Intervention of Amifostine for benzene-induced blood toxicity in mice].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20061001

• [Amifostine in treatment of five patients with myelodysplastic syndrome].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20061001

• Prevention of acute radiation-induced rectal toxicity by amifostine: efficacy and evaluation of objective and subjective endpoints for radiation therapy-induced mucositis.

  Supportive cancer therapy 20061001

• Phase II trial of adjuvant gemcitabine plus cisplatin-based chemotherapy in patients with locally advanced bladder cancer.

  Clinical genitourinary cancer 20060901

• Zebrafish as a 'biosensor'? Effects of ionizing radiation and amifostine on embryonic viability and development.

  Cancer research 20060815

• Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II study.

  British journal of cancer 20060807

• Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060801

• Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53.

  Cancer gene therapy 20060801

• Future opportunities in preventing cisplatin induced ototoxicity.

  Cancer treatment reviews 20060801

• Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy with amifostine 5 times weekly: A prospective randomized study in squamous cell head and neck cancer.

  Cancer 20060801

• Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses.

  Journal of dental research 20060801

• Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study.

  International journal of radiation oncology, biology, physics 20060715

• [Model of benzene induced aplastic anemia in mice and pathological changes of intervention of Amifostine].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060701

• Radiation injury to the rectum and amifostine.

  Supportive cancer therapy 20060701

• Amifostine in the management of radiation-induced and chemo-induced mucositis.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060601

• An anaphylactoid reaction from amifostine.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20060601

• Assessment of the radioprotective effects of amifostine and melatonin on human lymphocytes irradiated with gamma-rays in vitro.

  Arhiv za higijenu rada i toksikologiju 20060601

• Oral mucositis induced by anticancer treatments: physiopathology and treatments.

  Therapeutics and clinical risk management 20060601

• Evaluation, prevention and management of radiotherapy-induced xerostomia in head and neck cancer patients.

  Current opinion in oncology 20060501

• Neurologic toxicities of cancer therapies.

  Current neurology and neuroscience reports 20060501

• Oral mucositis.

  Oral diseases 20060501

• Usefulness of the SOS Chromotest in the study of medicinal plants as radioprotectors.

  International journal of radiation biology 20060501

• Interventions for preventing oral mucositis for patients with cancer receiving treatment.

  The Cochrane database of systematic reviews 20060419

• Effect of amifostine on the cytotoxicity of daunorubicin and daunoxome in tumor and normal cells.

  Cancer chemotherapy and pharmacology 20060401

• Antimutagenic effect of polysaccharide ginsan extracted from Panax ginseng.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060401

• [Early effect of amifostine in treating aged patients with idiopathic thrombocytopenia purpura].

  Zhongguo shi yan xue ye xue za zhi 20060401

• Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis.

  International journal of radiation oncology, biology, physics 20060301

• Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study.

  International journal of radiation oncology, biology, physics 20060301

• Should patients undergoing chemotherapy and radiotherapy be prescribed antioxidants?

  Integrative cancer therapies 20060301

• How to reduce radiation-related toxicity in patients with cancer of the head and neck.

  Current oncology reports 20060301

• Amifostine-induced back pain: a case report.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060215

• Amifostine administration during radiotherapy for cancer patients with genetic, autoimmune, metabolic and other diseases.

  Anti-cancer drugs 20060201

• The hematologic response to anti-apoptotic cytokine therapy: results of pentoxifylline, ciprofloxacin, and dexamethasone treatment for patients with myelodysplastic syndrome.

  Journal of Korean medical science 20060201

• Established and emerging uses of cytoprotection in head and neck cancer.

  Archives of otolaryngology--head & neck surgery 20060201

• Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy.

  Archives of otolaryngology--head & neck surgery 20060201

• [Oxaliplatin neurotoxicity].

  Bulletin du cancer 20060201

• Managing oral mucositis in patients with hematologic malignancies.

  The journal of supportive oncology 20060201

• New approaches to preventing xerostomia.

  The journal of supportive oncology 20060201

• Chemoradiotherapy for head and neck cancer: 'local' side effects are actually systemic.

  The journal of supportive oncology 20060201

• Trial of amifostine in autologous stem cell transplant.

  Bone marrow transplantation 20060101

• Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060101

• Plasmapheresis reverses all side-effects of a cisplatin overdose--a case report and treatment recommendation.

  BMC cancer 20060101

• Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: the Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study.

  BMC cancer 20060101

• Developmental therapeutics for myelodysplastic syndromes.

  Journal of the National Comprehensive Cancer Network : JNCCN 20060101

• Evaluation of analogues of DRDE-07 as prophylactic agents against the lethality and toxicity of sulfur mustard administered through percutaneous route.

  Journal of applied toxicology : JAT 20060101

• Improving the morbidity of anorectal injury from pelvic radiotherapy.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20060101

• Cytoprotective effect of amifostine in the treatment of childhood neoplastic diseases--a clinical study including the pharmacoeconomic analysis.

  Pharmacological reports : PR 20060101

• Potentiation of the antitumor effect of Merocyanine 540-mediated photodynamic therapy by amifostine and amphotericin B.

  Photochemistry and photobiology 20060101

• Clinical review: specific aspects of acute renal failure in cancer patients.

  Critical care (London, England) 20060101

• The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines.

  BMC cancer 20060101

• [Protective effect of amifostine on cisplatin-induced nephrotoxicity and its mechanism].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20060101

• External beam radiotherapy for prostate cancer: current position and trends.

  Anticancer research 20060101

• The effects of amifostine and dexamethasone on brain tissue lipid peroxidation during oxygen treatment of carbon monoxide-poisoned rats.

  Advances in therapy 20060101

• Comparison of uroprotective efficacy of mesna and amifostine in Cyclophosphamide- induced hemorrhagic cystitis in rats.

  Indian journal of cancer 20060101

• Nasopharyngeal carcinoma.

  Orphanet journal of rare diseases 20060101

• Individualization of the subcutaneous amifostine dose during hypofractionated / accelerated radiotherapy.

  Anticancer research 20060101

• Cytogenetic methods for biodosimetry and risk individualisation after exposure to ionising radiation.

  Radiation protection dosimetry 20060101

• Several therapies may prevent or reduce the severity of oral mucositis associated with cancer treatment.

  Evidence-based dentistry 20060101

• Prevention of oral mucositis in cancer patients treated with chemotherapy or radiotherapy.

  Evidence-based dentistry 20060101

• Amifostine improves hemodynamic parameters in doxorubicin-pretreated rabbits.

  Pharmacological reports : PR 20060101

• Amifostine-antioxidant drug in anticancer therapy.

  Toxicology mechanisms and methods 20060101

• The protective effects of amifostine on adriamycin-induced acute cardiotoxicity in rats.

  The Tohoku journal of experimental medicine 20051201

• Radioprotective effect of amifostine on parotid gland functioning is region dependent.

  International journal of radiation oncology, biology, physics 20051201

• The molecular immunology of mucositis: implications for evidence-based research in alternative and complementary palliative treatments.

  Evidence-based complementary and alternative medicine : eCAM 20051201

• Cytoprotection by amifostine during autologous stem cell transplantation for advanced refractory hematologic malignancies.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20051201

• Commentary: the pharmacological antioxidant amifostine -- implications of recent research for integrative cancer care.

  Integrative cancer therapies 20051201

• Management of xerostomia related to radiotherapy for head and neck cancer.

  Oncology (Williston Park, N.Y.) 20051201

• Management of oxaliplatin-induced peripheral neuropathy.

  Therapeutics and clinical risk management 20051201

• Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and- neck cancer: 2-year follow-up of a prospective, randomized, phase III trial.

  International journal of radiation oncology, biology, physics 20051115

• A comparative study on the protection profile of lidocaine, amifostine, and pilocarpin on the parotid gland during radiotherapy.

  Cancer research 20051115

• Radiation protectants: current status and future prospects.

  Health physics 20051101

• Implications of treatment-induced mucosal barrier injury.

  Current opinion in oncology 20051101

• Effects of insulin-like growth factor-1 (IGF-1) and amifostine in spinal cord reirradiation.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20051101

• Preventing radiation induced xerostomia.

  Cancer treatment reviews 20051101

• Doxorubicin induces apoptosis in germ line stem cells in the immature rat testis and amifostine cannot protect against this cytotoxicity.

  Cancer research 20051101

• Phase II trial of docetaxel in advanced or metastatic endometrial cancer: a Japanese Cooperative Study.

  British journal of cancer 20051031

• A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer.

  Cancer research 20051015

• Neuroprotection with amifostine in the first-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapy--a double-blind, placebo-controlled, randomized phase II study from the Arbeitsgemeinschaft Gynäkologische Onkologoie (AGO) Ovarian Cancer Study Group.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20051001

• Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without amifostine in patients with advanced head and neck carcinoma.

  Cancer 20051001

• What should the optimal timing be for amifostine administration relative to radiation and chemotherapy?

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051001

• Phase II study of tolerance and efficacy of hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and paclitaxel (taxol) and amifostine (ethyol) in head and neck squamous cell carcinomas: A-3 protocol.

  American journal of clinical oncology 20051001

• Hypofractionated accelerated radiotherapy with cytoprotection combined with trastuzumab, liposomal doxorubicine, and docetaxel in c-erbB-2-positive breast cancer.

  American journal of clinical oncology 20051001

• Adipocyte differentiation in Sod2(-/-) and Sod2(+/+) murine bone marrow stromal cells is associated with low antioxidant pools.

  Experimental hematology 20051001

• Amifostine exerts anti-angiogenic activity and suppresses vascular endothelial growth factor secreted by hemopoietic stem/progenitor cells.

  Saudi medical journal 20051001

• Radioprotectant combinations spare radiation-induced damage to the physis more than fractionation alone.

  International journal of radiation biology 20051001

• Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function, prediction, and prevention.

  International journal of radiation oncology, biology, physics 20050901

• Effects of amifostine on glycerol-pretreated rabbit kidneys.

  Basic & clinical pharmacology & toxicology 20050901

• Costs of treatment intensification for head and neck cancer: concomitant chemoradiation randomised for radioprotection with amifostine.

  European journal of cancer (Oxford, England : 1990) 20050901

• Amifostine and dexrazoxane enhance the rapid loss of bone mass and further deterioration of vertebrae architecture in female rats.

  Calcified tissue international 20050901

• Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study.

  Cancer 20050815

• Cytoprotective effects of amifostine and cysteamine on cultured normal and tumor cells treated with paclitaxel in terms of mitotic index and 3H-thymidine labeling index.

  Cancer chemotherapy and pharmacology 20050801

• Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy.

  International journal of radiation oncology, biology, physics 20050801

• [Morphological observation of amifostine's protective effect on radiation induced early middle ear injury].

  Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050801

• Influence of the cyto-protective agent amifostine on the pharmacokinetics of low-dose Paclitaxel.

  Chemotherapy 20050701

• Additive apoptotic effect of STI571 with the cytoprotective agent amifostine in K-562 cell line.

  Cancer chemotherapy and pharmacology 20050601

• A phase I trial of irinotecan (CPT-11) with amifostine in patients with metastatic colorectal cancer.

  Investigational new drugs 20050601

• Phase II multicenter randomized study of amifostine for prevention of acute radiation rectal toxicity: topical intrarectal versus subcutaneous application.

  International journal of radiation oncology, biology, physics 20050601

• Radiation-induced craniofacial bone growth inhibition: efficacy of cytoprotection following a fractionated dose regimen.

  Plastic and reconstructive surgery 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• [Short-term curative effect of amifostine combined with rhEPO on aged patients wilh myelodysplastic syndrome].

  Zhongguo shi yan xue ye xue za zhi 20050601

• Navigating external beam radiation therapy for head and neck cancer.

  Clinical journal of oncology nursing 20050601

• Head and neck squamous cell carcinoma: optimizing the therapeutic index.

  Expert review of anticancer therapy 20050601

• Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule.

  British journal of cancer 20050509

• Determination of WR-1065 in human blood by high-performance liquid chromatography following fluorescent derivatization by a maleimide reagent ThioGlo3.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

• Prospective randomised trial of amifostine cytoprotection in myeloma patients undergoing high-dose melphalan conditioned autologous stem cell transplantation.

  Bone marrow transplantation 20050501

• A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells.

  Journal of pineal research 20050501

• Radiopharmaceutical model using 99mTc-MIBI to evaluate amifostine protection against doxorubicin cardiotoxicity in rats.

  Annals of nuclear medicine 20050501

• A randomized phase II study of paclitaxel with carboplatin +/- amifostine as first line treatment in advanced ovarian carcinoma.

  Gynecologic oncology 20050401

• Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: radiation therapy oncology group trial 98-01.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050401

• Amifostine is a potent radioprotector of salivary glands in radioiodine therapy. Structural and ultrastructural findings.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20050401

• Clinical management of oxaliplatin-associated neurotoxicity.

  Clinical colorectal cancer 20050401

• Chemotherapy- and radiotherapy-induced oral mucositis: review of preventive strategies and treatment.

  Pharmacotherapy 20050401

• Does more aggressive therapy improve outcomes in the treatment of unresectable stage III non-small cell lung cancer?

  Seminars in oncology 20050401

• Pulmonary toxicity associated with the treatment of non-small cell lung cancer and the effects of cytoprotective strategies.

  Seminars in oncology 20050401

• Treatment-related esophagitis.

  Seminars in oncology 20050401

• Mutagen sensitivity may predict lung protection by amifostine for patients with locally advanced non-small cell lung cancer treated by chemoradiotherapy.

  Seminars in oncology 20050401

• Reduction of treatment breaks and radiation-induced esophagitis and pneumonitis using amifostine in unresectable non-small cell lung cancer patients receiving definitive concurrent chemotherapy and radiation therapy: a prospective community-based clinical trial.

  Seminars in oncology 20050401

• Amifostine in chemoradiation therapy for non-small cell lung cancer: review of experience and design of a phase II trial assessing subcutaneous and intravenous bolus administration.

  Seminars in oncology 20050401

• Phase II study of weekly vinorelbine and 24-h infusion of high-dose 5-fluorouracil plus leucovorin as first-line treatment of advanced breast cancer.

  British journal of cancer 20050328

• In regard to Boccia et al.: assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP) (INT J RADIAT ONCOL BIOL PHYS 2004;60:302-309).

  International journal of radiation oncology, biology, physics 20050315

• Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity.

  Life sciences 20050304

• Amifostine (ETHYOL) protects rats from mucositis resulting from fractionated or hyperfractionated radiation exposure.

  International journal of radiation oncology, biology, physics 20050301

• Paclitaxel and carboplatin with amifostine in advanced, recurrent, or refractory endometrial adenocarcinoma: a phase II study of the Southwest Oncology Group.

  Gynecologic oncology 20050301

• [Minutes of the 23th meeting of the European Society for Therapeutic Radiology and Oncology (ESTRO). Amsterdam, 24-28 October 2004].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20050301

• Concomitant boost radiation and concurrent cisplatin for advanced head and neck carcinomas. Preliminary results of a phase II, single-institutional trial.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20050301

• Radioprotection in mice following oral delivery of amifostine nanoparticles.

  International journal of radiation biology 20050301

• Ionizing radiation-induced damage on developing cerebellar granule cells cultures can be prevented by an early amifostine post-treatment.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20050201

• Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay.

  British journal of cancer 20050131

• Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20050101

• Oxaliplatin-associated neuropathy: a review.

  The Annals of pharmacotherapy 20050101

• Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.

  International journal of radiation oncology, biology, physics 20050101

• The relationship between the protective effect of amifostine and decreased intercellular adhesion molecule 1 expression.

  American journal of otolaryngology 20050101

• The role of radiation therapy in gastrointestinal bleeding.

  The journal of supportive oncology 20050101

• Triplet chemotherapy with docetaxel, gemcitabine and liposomal doxorubicin, supported with subcutaneous amifostine and hemopoietic growth factors, in advanced non-small cell lung cancer.

  Anticancer research 20050101

• Amifostine has an inhibitory effect on the radiation-induced p53-branched cascade in the immature mouse ovary.

  In vivo (Athens, Greece) 20050101

• Pathophysiology and management of radiation-induced xerostomia.

  The journal of supportive oncology 20050101

• Induction of caspase 3 activity, bcl-2 bax and p65 gene expression modulation in human acute promyelocytic leukemia HL-60 cells by doxorubicin with amifostine.

  Pharmacological reports : PR 20050101

• Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine.

  Pediatric hematology and oncology 20050101

• Use of amifostine, a novel cytoprotective, in alpha-amanitin poisoning.

  Clinical toxicology (Philadelphia, Pa.) 20050101

• In vivo study to evaluate the protective effects of amifostine on radiation-induced damage of testis tissue.

  Oncology 20050101

• Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer.

  BMC cancer 20050101

• [Treatment of the unresectable non small cell lung carcinoma].

  Casopis lekaru ceskych 20050101

• [Amifostine otoprotection to cisplatin ototoxicity: a guinea pig study using otoacoustic emission distortion products (DPOEA) and scanning electron microscopy].

  Brazilian journal of otorhinolaryngology 20050101

• Re-establishment of olfactory and taste functions.

  GMS current topics in otorhinolaryngology, head and neck surgery 20050101

• Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy.

  Pediatric blood & cancer 20041201

• [Protective effects of amifostine on hematopoietic stem/progenitor cells against chemotherapeutic damage].

  Zhongguo shi yan xue ye xue za zhi 20041201

• The evaluation of amifostine for mucosal protection in patients with advanced loco-regional squamous cell carcinomas of the head and neck (SCCHN) treated with concurrent weekly carboplatin, paclitaxel, and daily radiotherapy (RT).

  Seminars in oncology 20041201

• Toxicity and compliance of subcutaneous amifostine in patients undergoing postoperative intensity-modulated radiation therapy for head and neck cancer.

  Seminars in oncology 20041201

• A randomized phase II trial of amifostine for head and neck irradiation in lymphoma.

  Seminars in oncology 20041201

• A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing.

  Seminars in oncology 20041201

• Radiotherapy-induced salivary dysfunction.

  Seminars in oncology 20041201

• The role of amifostine in the treatment of carcinoma of the uterine cervix: an update of RTOG-0116 and review of future directions.

  Seminars in oncology 20041201

• Open label multicenter trial of subcutaneous amifostine (Ethyol) in the prevention of radiation induced esophagitis and pneumonitis in patients with measurable, unresectable non-small cell lung cancer.

  Seminars in oncology 20041201

• Randomized phase II study of amifostine mucosal protection by either subcutaneous injection or rapid IV bolus for patients with inoperable stage II-IIIA/B or stage IV non-small cell lung cancer with oligometastases receiving concurrent radiochemotherapy with carboplatin and paclitaxel followed by optional consolidative chemotherapy: a follow-up study after RTOG 98-01.

  Seminars in oncology 20041201

• Can the use of amifostine improve cure rates for patients with advanced non-small cell lung cancer?

  Seminars in oncology 20041201

• Phase I study for poor-prognosis lymphoma: augmentation of the 'BEAM' regimen with escalating dose melphalan using amifostine cytoprotection and autologous hematopoietic stem cell transplantation--a preliminary report.

  Seminars in oncology 20041201

• Randomized trials of amifostine and radiotherapy: effect on survival?

  Seminars in oncology 20041201

• Cytoprotection in acute myelogenous leukemia (AML) therapy.

  Seminars in oncology 20041201

• Proceedings of the Fourth International Cytoprotection Investigators' Congress. May 2004. Philadelphia, Pennsylvania, USA.

  Seminars in oncology 20041201

• Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.

  Radiation research 20041101

• Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC).

  International journal of radiation oncology, biology, physics 20041001

• The protective effect of amifostine on radiation-induced acute pulmonary toxicity: detection by (99m)Tc-DTPA transalveolar clearances.

  International journal of radiation oncology, biology, physics 20041001

• Comment on: 'Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients' Radiother Oncol 70: 261-264, 2004 by Dr Rades et al.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20041001

• Study of cisplatin-vinblastine plus amifostine in patients with locally advanced or metastatic non-small cell lung cancer.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20041001

• WR-2721 (Amifostine) ameliorates cisplatin-induced hearing loss but causes neurotoxicity in hamsters: dose-dependent effects.

  Journal of the Association for Research in Otolaryngology : JARO 20040901

• Oral delivery of spray dried PLGA/amifostine nanoparticles.

  The Journal of pharmacy and pharmacology 20040901

• Assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP).

  International journal of radiation oncology, biology, physics 20040901

• Combinations of radioprotectants spare radiation-induced damage to the physis.

  Clinical orthopaedics and related research 20040901

• A phase II randomized study of topical intrarectal administration of amifostine for the prevention of acute radiation-induced rectal toxicity.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040901

• High-dose Cisplatin with amifostine: ototoxicity and pharmacokinetics.

  The Laryngoscope 20040901

• Amifostine reduces radiation therapy-induced dry mouth in head and neck cancer patients.

  Oncology (Williston Park, N.Y.) 20040901

• Radioprotective effects of amifostine in vitro and in vivo measured with the comet assay.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040801

• Understanding the mechanisms of drug-associated interstitial lung disease.

  British journal of cancer 20040801

• [Effect of S-2-(3-aminopropylamino) ethyl phosphorothioic acid on apoptosis and proliferation inhibition of HL-60 cell line].

  Zhongguo shi yan xue ye xue za zhi 20040801

• Impact on cytoprotective efficacy of intermediate interval between amifostine administration and radiotherapy: a retrospective analysis.

  International journal of radiation oncology, biology, physics 20040715

• WR-1065, the active form of amifostine, protects HL-60 cells but not peripheral blood mononuclear cells from radiation and etoposide-induced apoptosis.

  International journal of radiation oncology, biology, physics 20040701

• Amifostine and autologous hematopoietic stem cell support of escalating-dose melphalan: a phase I study.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040701

• A randomized trial of amifostine as a cytoprotectant for patients receiving myeloablative therapy for allogeneic hematopoietic stem cell transplantation.

  Bone marrow transplantation 20040701

• [Future therapy strategies for salivary gland impairment].

  Refu'at ha-peh veha-shinayim (1993) 20040701

• Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury.

  The British journal of radiology 20040601

• [The protective effect of amifostine on hydroquinone-induced apoptosis in bone marrow].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20040601

• Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer.

  International journal of radiation oncology, biology, physics 20040501

• Effect of melatonin, ascorbic acid, and succinic acid on the cumulative toxic effect of repeated treatment with gammafos (amifostine).

  Bulletin of experimental biology and medicine 20040501

• Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats.

  British journal of cancer 20040419

• Activity of single-agent melphalan 220-300 mg/m2 with amifostine cytoprotection and autologous hematopoietic stem cell support in non-Hodgkin and Hodgkin lymphoma.

  Bone marrow transplantation 20040401

• Oxidative study of patients with total body irradiation: effects of amifostine treatment.

  Bone marrow transplantation 20040401

• Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial.

  International journal of radiation oncology, biology, physics 20040401

• Amifostine feasibility and efficacy in autologous stem cell transplantation for multiple myeloma.

  Haematologica 20040401

• A randomized trial of amifostine and carmustine-containing chemotherapy to assess lung-protective effects.

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040401

• Stevens-Johnson syndrome after amifostine during radiotherapy.

  International journal of dermatology 20040401

• Anal cancer and its precursors in HIV-positive patients: perspectives and management.

  Surgical oncology clinics of North America 20040401

• The potential cardioprotective effects of amifostine in irradiated rats.

  International journal of radiation oncology, biology, physics 20040315

• Enzyme-catalyzed activation of anticancer prodrugs.

  Pharmacological reviews 20040301

• Preparation and in vitro characterization of amifostine biodegradable microcapsules.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040301

• Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20040301

• [How I treat...oropharyngeal mucositis associated with radiotherapy for head and neck cancer].

  Revue medicale de Liege 20040301

• Amifostine as differentiating agent in cord blood and bone marrow cultures from children with hematological disorders.

  Pediatric hematology and oncology 20040301

• Novel radioprotectant drugs for sparing radiation-induced damage to the physis.

  International journal of radiation biology 20040301

• Comparative study between the interaction of dephosphorylated amifostine (WR-1065) and amoxicilline with pBR322 in absence and presence of cisplatin by AFM.

  International journal of pharmaceutics 20040211

• Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20040201

• Increased deposition of von Willebrand factor in the rat heart after local ionizing irradiation.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040201

• The radioprotectors amifostine and sodium selenite do not modify the radiosensitivity of rat rhabdomyosarcomas.

  Onkologie 20040201

• Dactinomycin-induced veno-occlusive disease in rats. The hepatoprotective action of amifostine. Evaluation in a light and electron microscope.

  Folia morphologica 20040201

• Quality of life with well-differentiated thyroid cancer: treatment toxicities and their reduction.

  Thyroid : official journal of the American Thyroid Association 20040201

• Amifostine protection against doxorubicin cardiotoxicity in rats.

  Anti-cancer drugs 20040201

• An evaluation of gemcitabines differential radiosensitising effect in related bladder cancer cell lines.

  British journal of cancer 20040126

• Neurophysiological study of peripheral neuropathy after high-dose Paclitaxel: lack of neuroprotective effect of amifostine.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040115

• Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha.

  Cancer chemotherapy and pharmacology 20040101

• Disposition of WR-1065 in the liver of tumor-bearing rats following regional vs systemic administration of amifostine.

  Biopharmaceutics & drug disposition 20040101

• Amifostine-induced fever: case report and review of the literature.

  Pharmacotherapy 20040101

• Radioprotective effects of amifostine (WR-2721) or cystamine on radiation damage and its repair in rats whole body exposed to fission neutrons.

  Acta medica (Hradec Kralove) 20040101

• Heterogeneous planning for homogeneous protocols.

  Medical dosimetry : official journal of the American Association of Medical Dosimetrists 20040101

• The potential influence of cell protectors for dose escalation in cancer therapy: an analysis of amifostine.

  Medical dosimetry : official journal of the American Association of Medical Dosimetrists 20040101

• The effect of cytoprotective agents in platinum anticancer therapy.

  Metal ions in biological systems 20040101

• Amifostine protects against chemotherapy-induced neurotoxicity: an in vitro investigation.

  Anticancer research 20040101

• Amifostine stimulates the formation of hematopoietic bone marrow progenitors from B-cell chronic lymphocytic leukemia.

  Acta haematologica 20040101

• Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.

  In vivo (Athens, Greece) 20040101

• Effects of amifostine on healing of microvascular anastomoses, flap survival, and nerve regeneration with preoperative or postoperative irradiation.

  Microsurgery 20040101

• Conformal hypofractionated and accelerated radiotherapy with cytoprotection (HypoARC) for high risk prostatic carcinoma: rationale, technique and early experience.

  Anticancer research 20040101

• Outcome of local application of amifostine (WR-1065) on epirubicin-induced oral mucositis. A phase II study.

  Anticancer research 20040101

• Tissue levels of WR-1065, the active metabolite of amifostine (Ethyol), are equivalent following intravenous or subcutaneous administration in cynomolgus monkeys.

  Oncology 20040101

• Cytoprotection in head and neck cancer: issues in oral care.

  The journal of supportive oncology 20040101

• Non-small cell lung cancer: the role of cytoprotection in treating therapy-related toxicity.

  The journal of supportive oncology 20040101

• Managing toxicities in pelvic malignancies.

  The journal of supportive oncology 20040101

• Prevention of radiation-induced central nervous system toxicity: a role for amifostine?

  Anticancer research 20040101

• A randomized trial of amifostine as radioprotector in the radiotherapy of head and neck cancer.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20040101

• Lack of cytoprotective effect of amifostine following HLA-identical sibling transplantation for advanced myelodysplastic syndrome (MDS): a pilot study.

  Bone marrow transplantation 20031201

• Phase II randomized trial of cisplatin and WR-2721 versus cisplatin alone for metastatic melanoma: an Eastern Cooperative Oncology Group Study (E1686).

  Melanoma research 20031201

• Proceedings of the 3rd International Cytoprotection Investigators' Congress. May 15-18, 2003, Nevis, West Indies.

  Seminars in oncology 20031201

• Amifostine reduces radiochemotherapy-induced toxicities in patients with locally advanced non-small cell lung cancer.

  Seminars in oncology 20031201

• Radioprotective effect of amifostine in radiation pneumonitis.

  Seminars in oncology 20031201

• Amifostine: is there evidence of tumor protection?

  Seminars in oncology 20031201

• Effects of dose and schedule on the efficacy of ethyol: preclinical studies.

  Seminars in oncology 20031201

• Rationale for integrating high-dose rate intraoperative radiation (HDR-IORT) and postoperative external beam radiation with subcutaneous amifostine for the management of stage III/IV head and neck cancer.

  Seminars in oncology 20031201

• Feasibility of amifostine administration in conjunction with high-dose rate brachytherapy.

  Seminars in oncology 20031201

• Amifostine and external beam radiation therapy and/or high-dose rate brachytherapy in the treatment of localized prostate carcinoma: preliminary results of a phase II trial.

  Seminars in oncology 20031201

• Clinical trial of endorectal amifostine for radioprotection in patients with prostate cancer: rationale and early results.

  Seminars in oncology 20031201

• Cytoprotection/radioprotection with amifostine: potential role in cervical cancer and early findings in the Radiation Therapy Oncology Group C-0116 trial.

  Seminars in oncology 20031201

• Aggressive multimodality therapy for patients with locally advanced esophageal cancer: is there a role for amifostine?

  Seminars in oncology 20031201

• The effect of oral mucositis on morbidity and mortality in bone marrow transplant.

  Seminars in oncology 20031201

• Phase II randomized study of concomitant chemoradiation using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with newly diagnosed locally advanced squamous cell carcinoma of the head and neck.

  Seminars in oncology 20031201

• Ongoing prospective multicenter safety study of the cytoprotectant amifostine given subcutaneously: overview of trial design.

  Seminars in oncology 20031201

• Pilot study of subcutaneous amifostine in patients undergoing postoperative intensity modulated radiation therapy for head and neck cancer: preliminary data.

  Seminars in oncology 20031201

• Toxicity profile of intensity-modulated radiation therapy for head and neck carcinoma and potential role of amifostine.

  Seminars in oncology 20031201

• Myeloprotective effects of different amifostine regimens in rabbits undergoing high-dose treatment with 186rhenium-(tin)1,1- hydroxyethylidene diphosphonate (186Re-HEDP).

  Cancer biotherapy & radiopharmaceuticals 20031201

• Serious cutaneous reactions to amifostine.

  Prescrire international 20031201

• Full dose paclitaxel plus vinorelbine as salvage chemotherapy in anthracycline-resistant advanced breast cancer: a phase II study.

  Journal of chemotherapy (Florence, Italy) 20031201

• A phase II irinotecan-cisplatin combination in advanced pancreatic cancer.

  British journal of cancer 20031117

• Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage.

  International journal of radiation oncology, biology, physics 20031115

• Radiation-induced cognitive dysfunction: the protective effect of ethyol in young rats.

  International journal of radiation oncology, biology, physics 20031115

• Limited access trial using amifostine for protection against cisplatin- and three-hour paclitaxel-induced neurotoxicity: a phase II study of the Gynecologic Oncology Group.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031115

• Subcutaneous administration of amifostine (ethyol) is equivalent to intravenous administration in a rat mucositis model.

  International journal of radiation oncology, biology, physics 20031101

• Amifostine has antiangiogenic properties in vitro by changing the redox status of human endothelial cells.

  Free radical research 20031101

• [Radiation protectants of the crystalline lens].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20031101

• Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress.

  Journal of molecular medicine (Berlin, Germany) 20031001

• Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non-small-cell lung cancer.

  International journal of radiation oncology, biology, physics 20031001

• Amifostine and chemoradiation therapy: ASCO responds.

  The Lancet. Oncology 20031001

• Moist skin care can diminish acute radiation-induced skin toxicity.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20031001

• Radioprotective effect of amifostine on cells from cancer prone patients and healthy individuals studied by the G2 and PCC assays.

  International journal of radiation biology 20031001

• Assessment of the protective effects of amifostine against cisplatin-induced toxicity.

  The Journal of otolaryngology 20031001

• n-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis.

  British journal of cancer 20030915

• Amifostine does not reduce the toxicity of the fludarabine and cyclophosphamide regimen in patients with chronic lymphocytic leukemia.

  Cancer chemotherapy and pharmacology 20030901

• Cisplatin nephrotoxicity affects magnesium and calcium metabolism.

  Medical and pediatric oncology 20030901

• Radioprotection of normal tissue to improve radiotherapy: the effect of the Bowman Birk protease inhibitor.

  Current medicinal chemistry. Anti-cancer agents 20030901

• Amifostine, in a reduced dose, protects against severe diarrhea associated with weekly fluorouracil and folinic acid chemotherapy in advanced colorectal cancer: a pilot study.

  Journal of pain and symptom management 20030901

• Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells.

  Molecular cancer therapeutics 20030901

• Amifostine before chemotherapy: improved tolerance profile of the subcutaneous over the intravenous route.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030815

• Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20030801

• Amifostine pretreatment for protection against topotecan-induced hematologic toxicity: results of a multicenter phase III trial in patients with advanced gynecologic malignancies.

  Gynecologic oncology 20030801

• Transiently increased bone density after irradiation and the radioprotectant drug amifostine in a rat model.

  American journal of clinical oncology 20030801

• [Cytoprotective effects of amifostine in the treatment of tumors].

  Vnitrni lekarstvi 20030801

• Oxaliplatin-safety profile: neurotoxicity.

  Seminars in oncology 20030801

• Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: results of a randomized trial.

  International journal of radiation oncology, biology, physics 20030715

• Amifostine does not preferentially stimulate the growth of residual polyclonal progenitor cells in myelodysplastic syndromes.

  Leukemia research 20030701

• High frequency of temperature-sensitive mutations of p53 tumor suppressor in acute myeloid leukemia revealed by functional assay in yeast.

  International journal of oncology 20030701

• Residual chromosomal damage after radiochemotherapy with and without amifostine detected by 24-color FISH.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030701

• Sequential histomorphometric analysis of the growth plate following irradiation with and without radioprotection.

  The Journal of bone and joint surgery. American volume 20030701

• Phase III multicenter randomized trial of amifostine as cytoprotectant in first-line chemotherapy in ovarian cancer patients.

  Annals of oncology : official journal of the European Society for Medical Oncology 20030701

• Radiation-induced lung injury.

  Seminars in radiation oncology 20030701

• Oral candidiasis in head and neck cancer patients receiving radiotherapy with amifostine cytoprotection.

  Oral oncology 20030601

• Re: Sodium thiosulfate in cisplatin overdose by Erdlenbruch B et al., Med Pediatr Oncol 2002;38:349-352.

  Medical and pediatric oncology 20030601

• Does amifostine have a role in chemoradiation treatment?

  The Lancet. Oncology 20030601

• Randomized phase III trial of postoperative radiochemotherapy +/- amifostine in head and neck cancer. Is there evidence for radioprotection?

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030601

• [Countermeasures to neurological adverse reactions of chemotherapy].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030601

• Development of investigational radiation modifiers.

  Journal of the National Cancer Institute 20030507

• The relationship between local dose and loss of function for irradiated lung.

  International journal of radiation oncology, biology, physics 20030501

• Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable stage III non-small-cell lung cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501

• Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects.

  Thrombosis research 20030415

• WR-2721 (amifostine, ethyol) prevents motor and morphological changes induced by neonatal X-irradiation.

  Neurochemistry international 20030401

• The radiosensitising effect of gemcitabine and the influence of the rescue agent amifostine in vitro.

  European journal of cancer (Oxford, England : 1990) 20030401

• Phase I study of amifostine as a cytoprotector of the gemcitabine/cisplatin combination in patients with advanced solid malignancies.

  Anti-cancer drugs 20030401

• Amifostine plus erythropoietin in a patient with low-risk myelodysplastic syndrome.

  Annals of hematology 20030401

• Improved tolerability of chemotherapy in soft tissue sarcomas: old and new strategies.

  Expert review of anticancer therapy 20030401

• Adaptive intrapatient dose escalation of cisplatin in combination with low-dose vp16 in patients with nonsmall cell lung cancer.

  British journal of cancer 20030324

• Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo.

  Biochimica et biophysica acta 20030320

• Molecular analysis of local relapse in high-risk breast cancer patients: can radiotherapy fractionation and time factors make a difference?

  British journal of cancer 20030310

• p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection.

  British journal of cancer 20030310

• Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene.

  Radiation research 20030301

• Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030301

• Radioactive iodine and the salivary glands.

  Thyroid : official journal of the American Thyroid Association 20030301

• The radioprotective activities of turpentine-induced inflammation and alpha2-macroglobulin: the effect of dexamethasone on the radioprotective efficacy of the inflammation.

  Journal of radiation research 20030301

• Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.

  Mutation research 20030205

• Amifostine inhibits angiogenesis in vivo.

  The Journal of pharmacology and experimental therapeutics 20030201

• Phase I clinical and pharmacologic study of weekly cisplatin and irinotecan combined with amifostine for refractory solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030201

• Amifostine protects lymphocytes during radiotherapy and stimulates expansion of the CD95/Fas and CD31 expressing T-cells, in breast cancer patients.

  Cancer immunology, immunotherapy : CII 20030201

• Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols.

  Experimental and molecular pathology 20030201

• The impact of different antioxidant agents alone or in combination on reactive oxygen species, antioxidant enzymes and cytokines in a series of advanced cancer patients at different sites: correlation with disease progression.

  Free radical research 20030201

• Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: relationship to the cell cycle.

  Cell biology and toxicology 20030201

• Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin.

  Oncology reports 20030101

• Effects of irradiation on the appositional and longitudinal growth of the tibia and fibula of the rat with and without radioprotectant.

  Journal of pediatric orthopedics 20030101

• Studies on the radioprotective potency of amifostine on salivary glands of rats during fractionated irradiation: acute and late effects.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20030101

• Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy.

  Seminars in radiation oncology 20030101

• Effects of amifostine on clonogenic mesenchymal progenitors and hematopoietic progenitors exposed to radiation.

  Journal of pediatric hematology/oncology 20030101

• Mucosal injury in patients undergoing hematopoietic progenitor cell transplantation: new approaches to prophylaxis and treatment.

  Bone marrow transplantation 20030101

• Amifostine protects against cisplatin-induced nephrotoxicity in a child with medulloblastoma.

  Pediatric hematology and oncology 20030101

• Has the time come for routine use of amifostine in clinical radiotherapy practice?

  Acta oncologica (Stockholm, Sweden) 20030101

• Effects of amifostine on radiation-induced cardiac damage.

  Acta oncologica (Stockholm, Sweden) 20030101

• Reactive oxygen species, antioxidant mechanisms, and serum cytokine levels in cancer patients: impact of an antioxidant treatment.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20030101

• Efficiency of amifostine as a protection against doxorubicin toxicity in rats during a 12-day treatment.

  Anticancer research 20030101

• Six-week induction chemotherapy followed by concomitant chemoradiation therapy in stage IV head and neck cancer: a phase II study with organ-sparing purposes.

  Oncology reports 20030101

• Changes in hemopoietic precursors after treatment of low-risk myelodysplasia with amifostine.

  In vivo (Athens, Greece) 20030101

• Amifostine and curative intent chemoradiation for compromised cancer patients.

  Anticancer research 20030101

• Protection against cisplatin-induced nephrotoxicity by recombinant human erythropoietin.

  Medical oncology (Northwood, London, England) 20030101

• Protective effect of amifostine against cisplatin-induced motor neuropathy in rat.

  Medical oncology (Northwood, London, England) 20030101

• [Dermatologic reactions to amifostine].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20030101

• Variable cytotoxicity of amifostine in malignant and non-malignant cell lines.

  Oncology reports 20030101

• Interventions for preventing oral mucositis for patients with cancer receiving treatment.

  The Cochrane database of systematic reviews 20030101

• Induction of caspase 3 and modulation of some apoptotic genes in human acute promyelocytic leukemia HL-60 cells by carboplatin with amifostine.

  Polish journal of pharmacology 20030101

• Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer: a single center randomized study.

  Medical oncology (Northwood, London, England) 20030101

• Side effects of ifosfamide.

  Oncology 20030101

• [Current status and perspectives of using radioprotectors in clinical practice].

  Likars'ka sprava 20030101

• [Role of etiol (amifostine) in the treatment of patients with malignant lymphoma].

  Likars'ka sprava 20030101

• The radioprotective agent, amifostine, suppresses the reactivity of intralysosomal iron.

  Redox report : communications in free radical research 20030101

• Target definition and contouring in carcinoma of the lung and esophagus.

  Rays 20030101

• Protection against cyclophosphamide-induced renal oxidative stress by amifostine: the role of antioxidative mechanisms.

  Toxicology mechanisms and methods 20030101

• Regional pharmacokinetics of amifostine in anesthetized dogs: role of the liver, gastrointestinal tract, lungs, and kidneys.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Amifostine reduces mucosal damage after high-dose melphalan conditioning and autologous peripheral blood progenitor cell transplantation for patients with multiple myeloma.

  Bone marrow transplantation 20021201

• Amifostine differentially modulates DNA damage evoked by idarubicin in normal and leukemic cells.

  Leukemia research 20021201

• Myelodysplasia and the acute myeloid leukaemias.

  Hematology (Amsterdam, Netherlands) 20021201

• Influence of amifostine on reconstitution of lymphocyte subpopulations after conventional- and high-dose chemotherapy in patients with germ cell tumor.

  Annals of hematology 20021201

• [Radioprotective effects on head and neck tumors of amifostine--a broad-spectrum cytoprotection].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20021201

• Proceedings of the 2nd International Cytoprotection Investigators' Congress. June 6-9, 2002. St Thomas, US Virgin Islands, USA.

  Seminars in oncology 20021201

• Preclinical studies on the radioprotective efficacy and pharmacokinetics of subcutaneously administered amifostine.

  Seminars in oncology 20021201

• Improved tolerability of amifostine with rapid infusion and optimal patient preparation.

  Seminars in oncology 20021201

• Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity.

  Seminars in oncology 20021201

• Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice.

  Seminars in oncology 20021201

• Early results from a phase I/II radiation dose-escalation study with concurrent amifostine and infusional 5-fluorouracil chemotherapy for preoperative treatment of unresectable or locally recurrent rectal carcinoma.

  Seminars in oncology 20021201

• Potential for use of amifostine in cervical cancer.

  Seminars in oncology 20021201

• A phase III randomized evaluation of amifostine in stage IIIA/IIIB non-small cell lung cancer patients receiving concurrent carboplatin, paclitaxel, and radiation therapy followed by gemcitabine and cisplatin intensification: preliminary findings.

  Seminars in oncology 20021201

• Hypofractionated and accelerated radiotherapy with amifostine cytoprotection (HypoARC): a new concept in radiotherapy and encouraging results in breast cancer.

  Seminars in oncology 20021201

• The potential of amifostine in high-dose chemotherapy and autologous hematopoietic stem cell transplantation.

  Seminars in oncology 20021201

• Preliminary data of the GORTEC 2000-02 phase III trial comparing intravenous and subcutaneous administration of amifostine for head and neck tumors treated by external radiotherapy.

  Seminars in oncology 20021201

• Radioprotective effect of amifostine in patients with head and neck squamous cell carcinoma.

  Seminars in oncology 20021201

• Tools for optimal tissue sparing in concomitant chemoradiation of advanced head and neck cancer: subcutaneous amifostine and computed tomography-based target delineation.

  Seminars in oncology 20021201

• Phase II trial of subcutaneous amifostine in patients undergoing radiation therapy for head and neck cancer.

  Seminars in oncology 20021201

• New strategies for the prevention of radiation injury: possible implications for countering radiation hazards of long-term space travel.

  Journal of radiation research 20021201

• [Myelodysplastic syndromes. Diagnosis and therapeutic strategies].

  Medizinische Klinik (Munich, Germany : 1983) 20021115

• Amifostine does not prevent activation of TGFbeta1 but induces smad 7 activation in megakaryocytes irradiated in vivo.

  American journal of hematology 20021101

• DNA damage and repair in BCR/ABL-expressing cells after combined action of idarubicin, STI571 and amifostine.

  Anti-cancer drugs 20021101

• Amifostine-induced toxic epidermal necrolysis during radiotherapy: a case report.

  Japanese journal of clinical oncology 20021101

• A pilot study on feasibility and efficacy of amifostine preceding high-dose melphalan with autologous stem cell support in myeloma patients.

  Leukemia & lymphoma 20021001

• Definitive radiotherapy for squamous carcinoma of the larynx.

  Otolaryngologic clinics of North America 20021001

• Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity.

  European journal of cancer (Oxford, England : 1990) 20020901

• Amifostine aminothiols and protection of keratinocyte apoptosis and DNA damage.

  The Journal of investigative dermatology 20020901

• [Reducing late toxicity with amifostine in fractionated irradiation of the rat salivary glands].

  HNO 20020901

• Concurrent administration of Docetaxel and Stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection.

  British journal of cancer 20020812

• Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen.

  American journal of physiology. Lung cellular and molecular physiology 20020801

• A pilot study of topical intrarectal application of amifostine for prevention of late radiation rectal injury.

  International journal of radiation oncology, biology, physics 20020801

• In regard to Antonadou et al. Randomized trial investigating the effects of daily amifostine in addition to radiation therapy in 146 patients with advanced lung cancers.

  International journal of radiation oncology, biology, physics 20020801

• A phase I study of idarubicin dose escalation with amisfostine and high-dose cytarabine in patients with relapsed acute myelogenous leukemia and myelodysplastic syndromes.

  Haematologica 20020801

• Effects of WR-2721 and cyclophosphamide on the cell cycle phase specificity of apoptosis in mouse bone marrow.

  Anti-cancer drugs 20020801

• Cytoprotective effect of amifostine in radiation-induced acute mucositis - a retrospective analysis.

  Onkologie 20020801

• Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine.

  Radiation research 20020701

• Clinical and biological effects of treatment with amifostine in myelodysplastic syndromes.

  British journal of haematology 20020701

• In vivo protection by amifostine and DRDE-07 against sulphur mustard toxicity.

  Human & experimental toxicology 20020701

• 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American Society of Clinical Oncology.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020615

• New liquid chromatographic assay with electrochemical detection for the measurement of amifostine and WR1065.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020605

• Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity.

  Radiation research 20020601

• Radioprotection, pharmacokinetic and behavioural studies in mouse implanted with biodegradable drug (amifostine) pellets.

  International journal of radiation biology 20020601

• Flow cytometric detection of apoptotic bone marrow cells with fractional DNA content after application of WR-2721, cyclophosphamide, cisplatin, and exposure of mice to gamma rays.

  Human & experimental toxicology 20020601

• [Effect of amifostine on reducing acute toxicity of megachemotherapy of tumors in children].

  Casopis lekaru ceskych 20020524

• Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines.

  British journal of cancer 20020506

• Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

• Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine.

  International journal of radiation oncology, biology, physics 20020501

• BNP7787, a novel protector against platinum-related toxicities, does not affect the efficacy of cisplatin or carboplatin in human tumour xenografts.

  European journal of cancer (Oxford, England : 1990) 20020501

• No evidence that amifostine influences the plasma pharmacokinetics of topotecan in ovarian cancer patients.

  European journal of clinical pharmacology 20020501

• Prevention of oxaliplatin-induced peripheral sensory neuropathy by carbamazepine in patients with advanced colorectal cancer.

  Clinical colorectal cancer 20020501

• Genotoxicity of idarubicin and its modulation by vitamins C and E and amifostine.

  Chemico-biological interactions 20020420

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Phase II trial of irinotecan in combination with amifostine in patients with advanced colorectal carcinoma.

  Cancer 20020415

• Efficacy of radioprotection in the prevention of radiation-induced craniofacial bone growth inhibition.

  Plastic and reconstructive surgery 20020401

• Treatment of anemia in low-risk myelodysplastic syndromes with amifostine. In vitro testing of response.

  Annals of hematology 20020401

• Influence of amifostine on toxicity of CHOP in elderly patients with aggressive non-Hodgkin's lymphoma--a phase II study.

  Anti-cancer drugs 20020401

• Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer.

  International journal of radiation oncology, biology, physics 20020301

• Combined therapy with amifostine plus erythropoietin for the treatment of myelodysplastic syndromes.

  Haematologica 20020301

• Bleomycin genotoxicity and amifostine (WR-2721) cell protection in normal leukocytes vs. K562 tumoral cells.

  Biochemical pharmacology 20020301

• Amifostine in clinical oncology: current use and future applications.

  Anti-cancer drugs 20020301

• Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.

  Anti-cancer drugs 20020301

• Development of biodegradable microcapsules as carrier for oral controlled delivery of amifostine.

  Drug development and industrial pharmacy 20020301

• Flow cytometric estimation of the plasma membrane diversity of bone marrow cells in mice treated with WR-2721 and cyclophosphamide.

  Toxicology 20020227

• Effects of amifostine on the proliferation and differentiation of megakaryocytic progenitor cells.

  European journal of pharmacology 20020215

• New dosing regimens for amifostine: a pilot study to compare the relative bioavailability of oral and subcutaneous administration with intravenous infusion.

  Journal of clinical pharmacology 20020201

• Relationships between cytoprotection and mutation prevention by WR-1065.

  Military medicine 20020201

• Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines.

  Anti-cancer drugs 20020201

• Acute myeloblastic leukemia achieving complete remission with amifostine alone.

  Leukemia & lymphoma 20020201

• [Radioprotective effectiveness of amifostine on the salivary glands of the rat during fractionated irradiation].

  HNO 20020201

• Inhibition of spontaneous metastases formation by amifostine.

  International journal of cancer 20020110

• Radioprotection of head and neck tissue by amifostine.

  Frontiers of radiation therapy and oncology 20020101

• Hypofractionated and accelerated radiotherapy with cytoprotection (HypoARC): a short, safe, and effective postoperative regimen for high-risk breast cancer patients.

  International journal of radiation oncology, biology, physics 20020101

• Influence of amifostine on the toxicity and pharmacokinetics of docetaxel in metastatic breast cancer patients: a pilot study.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020101

• Differential antigenotoxic and cytoprotective effect of amifostine in idarubicin-treated mice.

  Environmental and molecular mutagenesis 20020101

• Amifostine in simultaneous radiochemotherapy of advanced head and neck cancer.

  Seminars in radiation oncology 20020101

• A prospective, nonrandomized study of the impact of amifostine on subsequent hypothyroidism in irradiated patients with head and neck cancers.

  Seminars in radiation oncology 20020101

• A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer.

  Seminars in radiation oncology 20020101

• Protection of salivary function by intensity-modulated radiation therapy in patients with head and neck cancer.

  Seminars in radiation oncology 20020101

• Phase II: trial of twice weekly amifostine in patients with non-small cell lung cancer treated with chemoradiotherapy.

  Seminars in radiation oncology 20020101

• Exploring the role of the radioprotector amifostine in locally advanced non-small cell lung cancer: Radiation Therapy Oncology Group trial 98-01.

  Seminars in radiation oncology 20020101

• Randomized phase III study of chemoradiation with or without amifostine for patients with favorable performance status inoperable stage II-III non-small cell lung cancer: preliminary results.

  Seminars in radiation oncology 20020101

• Radiotherapy or chemotherapy followed by radiotherapy with or without amifostine in locally advanced lung cancer.

  Seminars in radiation oncology 20020101

• Phase II evaluation of amifostine as an esophageal mucosal protectant in the treatment of limited-stage small cell lung cancer with chemotherapy and twice-daily radiation.

  Seminars in radiation oncology 20020101

• Esophageal cancer and the esophagus: challenges and potential strategies for selective cytoprotection of the tumor-bearing organ during cancer treatment.

  Seminars in radiation oncology 20020101

• The potential role of amifostine in the treatment of carcinoma of the uterine cervix: a review.

  Seminars in radiation oncology 20020101

• Intrarectal application of amifostine for the prevention of radiation-induced rectal injury.

  Seminars in radiation oncology 20020101

• Rationale for a phase I/II radiation dose-escalation study with concurrent amifostine (Ethyol) and infusional 5-FU chemotherapy for preoperative treatment of unresectable or locally recurrent rectal carcinoma.

  Seminars in radiation oncology 20020101

• Preclinical modeling of improved amifostine (Ethyol) use in radiation therapy.

  Seminars in radiation oncology 20020101

• Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells.

  Seminars in radiation oncology 20020101

• New approaches to the treatment of myelodysplasia.

  The oncologist 20020101

• [Amifostin in protection of kidney from cisplatinum injury].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020101

• Use of amifostine in the therapy of osteosarcoma in children and adolescents.

  Journal of pediatric hematology/oncology 20020101

• Amifostine as a radioprotectant.

  Clinical journal of oncology nursing 20020101

• Investigation of doxorubicin tissue toxicity: does amifostine provide chemoprotection? An experimental study.

  Anticancer research 20020101

• TEL/JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine.

  Acta biochimica Polonica 20020101

• Amifostine promotes hemopoietic progenitor cell mobilization in patients with myelodysplastic syndrome.

  Anticancer research 20020101

• The cytoprotective effect of amifostine in acute radiation dermatitis: a retrospective analysis.

  European journal of dermatology : EJD 20020101

• Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity.

  Experimental lung research 20020101

• Radioprotectants: current status and new directions.

  Oncology 20020101

• Head and neck cancer: managing xerostomia and other treatment induced side effects.

  ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses 20020101

• Amifostine protects blood vessels from the effects of ionizing radiation.

  Anticancer research 20020101

• Efficacy of combined radiation, paclitaxel and carboplatin for locally advanced non-small cell lung carcinoma.

  Anticancer research 20020101

• Phosphatidylserine externalization during bone marrow cell death after treatment of mice with WR-2721 and gamma-rays.

  Folia biologica 20020101

• Reactive oxygen species, antioxidant mechanisms and serum cytokine levels in cancer patients: impact of an antioxidant treatment.

  Journal of cellular and molecular medicine 20020101

• Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats.

  Drug metabolism and drug interactions 20020101

• Management of high-risk myelodysplastic syndromes.

  Critical reviews in oncology/hematology 20011201

• A randomized phase II study of amifostine used as stem cell protectant in non-hodgkin lymphoma patients receiving cisplatin-based salvage chemotherapy prior to stem cell transplant.

  Journal of hematotherapy & stem cell research 20011201

• Randomized phase III trial of radiation treatment +/- amifostine in patients with advanced-stage lung cancer.

  International journal of radiation oncology, biology, physics 20011115

• Alteration of radiation-induced hematotoxicity by amifostine.

  International journal of radiation oncology, biology, physics 20011115

• Radiation therapy and concurrent fixed dose amifostine with escalating doses of twice-weekly gemcitabine in advanced pancreatic cancer.

  International journal of radiation oncology, biology, physics 20011115

• A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncology Group Study (E8188).

  Cancer 20011115

• Blood thiols following amifostine and mesna infusions, a pediatric oncology group study.

  Drug metabolism and disposition: the biological fate of chemicals 20011101

• Protective effects of amifostine and its analogues on sulfur mustard toxicity in vitro and in vivo.

  Toxicology and applied pharmacology 20011001

• High-dose treatment with (186)Re-HEDP or (153)Sm-EDTMP combined with amifostine in a rabbit model.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20011001

• The role of amifostine as a radioprotector.

  Oncology (Williston Park, N.Y.) 20011001

• Poor prognosis acute myelogenous leukemia: 3--biological and molecular biological changes during remission induction therapy.

  Leukemia research 20010901

• Amifostine protects against early but not late toxic effects of doxorubicin in infant rats.

  Cancer research 20010901

• Has the outlook improved for amifostine as a clinical radioprotector.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010901

• Phase I trial of a twice-daily regimen of amifostine with ifosfamide, carboplatin, and etoposide chemotherapy in children with refractory carcinoma.

  Cancer 20010815

• Treatment of patients with myelodysplastic syndrome with amifostine.

  Leukemia research 20010801

• Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide.

  Journal of the American Society of Nephrology : JASN 20010801

• Pharmacologic study of paclitaxel administered with or without the cytoprotective agent amifostine, and given as a single agent or in combination with epirubicin and cisplatin in patients with advanced solid tumors.

  American journal of clinical oncology 20010801

• [Renal protection with amifostine during intraoperative peritoneal chemohyperthermia (IPCH) with cisplatin (CDDP) for peritoneal carcinosis. Phase 1 study].

  Minerva medica 20010801

• Assessment of amifostine as protection from chemotherapy-induced toxicities after conventional-dose and high-dose chemotherapy in patients with germ cell tumor.

  Annals of oncology : official journal of the European Society for Medical Oncology 20010801

• Amifostine does not inhibit the toxic effects of anthracycline derivates or mitoxantrone on MDR tumor cell lines.

  Leukemia & lymphoma 20010801

• Clinical applications of radioprotectors.

  Expert review of anticancer therapy 20010801

• Amifostine does not protect malignant lymphoma cell lines from the cytotoxic effects of various chemotherapeutics in vitro.

  Leukemia & lymphoma 20010701

• Prophylactic efficacy of amifostine and its analogues against sulphur mustard toxicity.

  Toxicology 20010621

• Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells.

  Free radical biology & medicine 20010615

• Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay.

  Oncogene 20010614

• Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs.

  The Journal of pharmacology and experimental therapeutics 20010601

• Selective radioprotection of hepatocytes by systemic and portal vein infusions of amifostine in a rat liver tumor model.

  International journal of radiation oncology, biology, physics 20010601

• Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone.

  International journal of radiation oncology, biology, physics 20010601

• Effect of amifostine on lipid peroxidation caused by cisplatin in rat kidney.

  Journal of chemotherapy (Florence, Italy) 20010601

• Phase I-II study of escalating doses of amifostine combined with high-dose cyclophosphamide.

  Cancer chemotherapy and pharmacology 20010601

• [Adjuvant chemotherapy of cervix carcinoma--results of a phase II study].

  Zentralblatt fur Gynakologie 20010501

• Preliminary report on reduction of esophagitis by amifostine in patients with non-small-cell lung cancer treated with chemoradiotherapy.

  Clinical lung cancer 20010501

• T-cell apoptosis induced by granulocyte colony-stimulating factor is associated with retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors.

  Experimental hematology 20010401

• Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study.

  Anti-cancer drugs 20010401

• [Comments on five clinical trials concerning radiotherapy-induced mucositis in patients with head and neck neoplasms].

  Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20010401

• High remission rate in acute myeloblastic leukemia with only two days of chemotherapy.

  Leukemia & lymphoma 20010401

• Clarification on the potential of subcutaneous ethyol as a radioprotective agent.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010301

• Dexrazoxane is a potent and specific inhibitor of anthracycline induced subcutaneous lesions in mice.

  Annals of oncology : official journal of the European Society for Medical Oncology 20010301

• Subcutaneous administration of amifostine: a promising therapeutic option in patients with oxaliplatin-related peripheral sensitive neuropathy.

  Annals of oncology : official journal of the European Society for Medical Oncology 20010301

• Amifostine: chemotherapeutic and radiotherapeutic protective effects.

  Expert opinion on pharmacotherapy 20010301

• In vivo effects of IL-4, IL-10, and amifostine on cytokine production in patients with acute myelogenous leukemia.

  Leukemia & lymphoma 20010301

• Preliminary results of amifostine administration in combination with recombinant human erythropoietin in patients with myelodysplastic syndromes.

  Journal of experimental & clinical cancer research : CR 20010301

• Phase III randomized trial of amifostine as a radioprotector in head and neck cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010215

• A randomized trial of amifostine in patients with high-dose VIC chemotherapy plus autologous blood stem cell transplantation.

  British journal of cancer 20010201

• Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds.

  Experimental hematology 20010201

• Amifostine alone and in combination with erythropoietin for the treatment of favorable myelodysplastic syndrome.

  Leukemia research 20010201

• Effect of amifostine on toxicities associated with salvage combination chemotherapy.

  The Journal of the Association of Physicians of India 20010201

• PBPC mobilization with paclitaxel, ifosfamide, and G-CSF with or without amifostine: results of a prospective randomized trial.

  Transfusion 20010201

• [Recommendations of the Working Group 'Supportive Massnahmen in der Onkologie' concerning the Clinical Use of Cytoprotectives].

  Onkologie 20010201

• A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer.

  British journal of cancer 20010101

• Anticancer drug-induced kidney disorders.

  Drug safety 20010101

• Effects of amifostine in a patient with an advanced-stage myelodysplastic syndrome.

  Annals of hematology 20010101

• Economic analysis of amifostine as adjunctive support for patients with advanced head and neck cancer: preliminary results from a randomized phase II clinical trial from Germany.

  Cancer investigation 20010101

• Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome.

  Drugs 20010101

• Immunocytochemical analysis of apoptotic bone marrow cells after treatment of mice with WR-2721 and chemotherapeutic drugs.

  Folia histochemica et cytobiologica 20010101

• Amifostine (Ethyol) as modulator of hepatic and biliary toxicity from intraarterial hepatic chemoembolization: results of a phase I study.

  Hepato-gastroenterology 20010101

• Effects of retinoic acid and amifostine on in vitro growth of normal hemopoietic progenitor cells.

  Anticancer research 20010101

• Quantitation of interferon regulatory factor transcripts in patients with acute myeloid leukemia.

  Cancer investigation 20010101

• Amifostine in combination with erythropoietin and G-CSF promotes multilineage hematopoiesis in patients with myelodysplastic syndrome.

  Leukemia & lymphoma 20010101

• [Development of cancer chemotherapy. Cytoprotective agents].

  La Clinica terapeutica 20010101

• Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients.

  Medical and pediatric oncology 20010101

• WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment.

  International journal of pancreatology : official journal of the International Association of Pancreatology 20010101

• High dose daily amifostine and hypofractionated intensively accelerated radiotherapy for locally advanced breast cancer. A phase I/II study and report on early and late sequellae.

  Anticancer research 20010101

• Sensitizers and protectors of radiation and chemotherapy.

  Current problems in cancer 20010101

• [Current approaches in prevention and therapy of chemo- and radiotherapy-induced oral mucositis].

  Wiener medizinische Wochenschrift (1946) 20010101

• Cardiovascular considerations with anthracycline use in patients with cancer.

  Heart disease (Hagerstown, Md.) 20010101

• Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation.

  International journal of cancer 20010101

• [Application of Ethyol during chemotherapy in patients with impaired kidney function. Description of three cases].

  Medycyna wieku rozwojowego 20010101

• Use of amifostine as a chemoprotectant during high-dose chemotherapy in autologous peripheral blood stem cell transplantation.

  Bone marrow transplantation 20001201

• Pilot trial of cytoprotection with amifostine given with high-dose chemotherapy and autologous peripheral blood stem cell transplantation.

  American journal of clinical oncology 20000801

• Amifostine can reduce mucosal damage after high-dose melphalan conditioning for peripheral blood progenitor cellautotransplant: a retrospective study.

  British journal of haematology 20000801

• Amifostine plus cisplatin plus vinorelbine in the treatment of advanced non small cell lung cancer: a multicenter phase II study.

  Lung cancer (Amsterdam, Netherlands) 20000601

• Systemic inflammatory response syndrome associated with amifostine.

  Medical and pediatric oncology 20000401

• Patients with myelodysplastic syndromes benefit from palliative therapy with amifostine, pentoxifylline, and ciprofloxacin with or without dexamethasone.

  Blood 20000301

• Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats.

  Cancer chemotherapy and pharmacology 20000101

• The use of reduced doses of amifostine to ameliorate nephrotoxicity of cisplatin/ifosfamide-based chemotherapy in patients with solid tumors.

  Anti-cancer drugs 20000101

• Experimental model of hepatic venoocclusive disease (VOD) caused by dactinomycin--preliminary report about hepatoprotective effect of amifostine.

  Medical science monitor : international medical journal of experimental and clinical research 20000101

• Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-kappaB/Rel transcription factors.

  Blood 19991215

• The potential of amifostine: from cytoprotectant to therapeutic agent.

  Haematologica 19991101

• Evaluation of uroprotective efficacy of amifostine against cyclophosphamide induced hemorrhagic cystitis.

  Bone marrow transplantation 19990301

• Protection of normal tissues from the cytotoxic effects of radiation therapy: focus on amifostine.

  Seminars in radiation oncology 19981001

• The efficacy of selenium, WR-2721, and their combination in the prevention of adriamycin-induced cardiotoxicity in rats.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 19980101

• Effect of amifostine on toxicities associated with sequential chemotherapy and radiation therapy for unresectable non-small-cell lung cancer: results of a phase II trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19970801

• Phase II evaluation of cisplatin and WR2721 for refractory metastatic breast cancer.

  American journal of clinical oncology 19970801

• Cytoprotective agents for anthracyclines.

  Seminars in oncology 19960801

• Hypotensive mechanisms of amifostine.

  Journal of clinical pharmacology 19960401

• Amifostine (Ethyol): dosing, administration and patient management guidelines.

  European journal of cancer (Oxford, England : 1990) 19960101

• Organic thiophosphate WR-151327 suppresses expression of HIV in chronically infected cells.

  AIDS research and human retroviruses 19940601

• Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil.

  Cancer chemotherapy and pharmacology 19920101

• Final report of the phase I trial of single-dose WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid].

  Cancer treatment reports 19861201

• Clinical trial of the effect of S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721) (NSC 296961) on the toxicity of cyclophosphamide.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19830301