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P-Glycoprotein on Blood-Brain Barrier Plays a Vital Role in Fentanyl Brain Exposure and Respiratory Toxicity in Rats.
Toxicological sciences : an official journal of the Society of Toxicology 20180701
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Increasing nerve agent treatment efficacy by P-glycoprotein inhibition.
Chemico-biological interactions 20161125
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Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.
Scientific reports 20150101
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Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo.
The Journal of pharmacology and experimental therapeutics 20120601
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Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Journal of medicinal chemistry 20120412
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[Evaluation of P-glycoprotein mediated in vitro loperamide biliary excretion with sandwich-cultured rat hepatocytes model].
Yao xue xue bao = Acta pharmaceutica Sinica 20120401
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Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate.
The AAPS journal 20120301
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Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data.
Clinical pharmacology and therapeutics 20120201
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A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
European journal of nuclear medicine and molecular imaging 20120101
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Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoni.
PLoS neglected tropical diseases 20111201
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Increasing oxime efficacy by blood-brain barrier modulation.
Toxicology letters 20110925
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Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.
Journal of medicinal chemistry 20110825
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Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
Journal of medicinal chemistry 20110728
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Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).
Bioorganic & medicinal chemistry letters 20110615
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A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110615
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The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration.
The Journal of antimicrobial chemotherapy 20110401
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Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Bioorganic & medicinal chemistry 20110315
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A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20110201
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Synthesis and in vivo evaluation of ¹⁸F-fluoroethyl GF120918 and XR9576 as positron emission tomography probes for assessing the function of drug efflux transporters.
Bioorganic & medicinal chemistry 20110115
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Specific inhibitors of the breast cancer resistance protein (BCRP).
ChemMedChem 20100903
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Synthesis and evaluation of [11C]XR9576 to assess the function of drug efflux transporters using PET.
Annals of nuclear medicine 20100601
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Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.
European journal of nuclear medicine and molecular imaging 20100501
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P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100401
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Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100301
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Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar.
NeuroImage 20100115
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Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
Bioorganic & medicinal chemistry letters 20100101
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A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20091201
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Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance.
Journal of controlled release : official journal of the Controlled Release Society 20090521
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A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine.
Clinical cancer research : an official journal of the American Association for Cancer Research 20090515
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Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.
Bioorganic & medicinal chemistry 20090315
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Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
Journal of medicinal chemistry 20090226
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Functional and energetic characterization of P-gp-mediated doxorubicin transport in rainbow trout (Oncorhynchus mykiss) hepatocytes.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090101
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Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice.
Journal of experimental & clinical cancer research : CR 20090101
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Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein.
Anesthesiology 20081201
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Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Epilepsy research 20081101
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Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080801
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Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.
Journal of cancer research and clinical oncology 20080501
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Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
Neuropharmacology 20080501
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Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Biochemical pharmacology 20080315
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Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Bioorganic & medicinal chemistry 20080301
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Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
Bioorganic & medicinal chemistry 20080101
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Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats.
The Journal of pharmacology and experimental therapeutics 20070701
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In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).
Bioorganic & medicinal chemistry 20070601
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Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein.
Tuberculosis (Edinburgh, Scotland) 20070501
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Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.
Epilepsia 20070301
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Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
Neuropharmacology 20070201
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Multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stress.
Psychoneuroendocrinology 20070101
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In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450.
Bioorganic & medicinal chemistry 20061201
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Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY.
Synapse (New York, N.Y.) 20061201
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The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity.
Clinical pharmacology and therapeutics 20060901
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Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer.
Current opinion in pharmacology 20060801
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Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 20060601
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Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia.
Nature neuroscience 20060401
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Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats.
Epilepsia 20060401
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Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators.
Bioorganic & medicinal chemistry 20060301
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Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma.
Cancer 20050815
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Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel.
Cancer biology & therapy 20050801
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The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.
FEBS letters 20050718
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Modulation of drug resistance transporters as a strategy for treating myelodysplastic syndrome.
Best practice & research. Clinical haematology 20041201
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P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment.
Journal of lipid research 20041001
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Ex vivo reversal of chemoresistance by tariquidar (XR9576).
Anti-cancer drugs 20041001
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Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
The Journal of biological chemistry 20040924
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Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy.
European journal of cancer (Oxford, England : 1990) 20040301
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Pheophorbide a is a specific probe for ABCG2 function and inhibition.
Cancer research 20040215
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Pumping of drugs by P-glycoprotein: a two-step process?
The Journal of pharmacology and experimental therapeutics 20031201
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The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031101
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Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030201
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In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line.
Clinical cancer research : an official journal of the American Association for Cancer Research 20011001
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In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
Cancer research 20010115