2140-46-7 | (8S,9S,10R,13R,14S,17R)-17-((R)-6-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
5mg	98%	in stock	$32.00	$22.00
10mg	98%	in stock	$62.00	$43.00
25mg	98%	in stock	$120.00	$84.00
100mg	98%	in stock	$220.00	$154.00

Description

• Catalog Number: AB49960
• Chemical Name: (8S,9S,10R,13R,14S,17R)-17-((R)-6-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS Number: 2140-46-7
• Molecular Formula: C27H46O2
• Molecular Weight: 402.6529
• MDL Number: MFCD00057815
• SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCCC(O)(C)C)C)C)C1)C

Computed Properties

• Complexity: 636
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• XLogP3: 6.8

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  The Journal of biological chemistry 20080104

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  Nature medicine 20071001

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  The Biochemical journal 20070801

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  The Journal of biological chemistry 20070720

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  Journal of lipid research 20070701

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  Experimental cell research 20070415

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  Brain research 20070316

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  Free radical research 20070301

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  Current eye research 20070301

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  The Journal of biological chemistry 20070223

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  Life sciences 20070109

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  The Journal of steroid biochemistry and molecular biology 20070101

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• Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20061101

• Induction of apoptosis by 25-hydroxycholesterol in adult rat Leydig cells: protective effect of 17beta-estradiol.

  Reproductive toxicology (Elmsford, N.Y.) 20061101

• [Synthesis and structure-activity relationships of bioactive compounds using sterols].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061101

• Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia.

  Neuropeptides 20061001

• Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects.

  Free radical biology & medicine 20060915

• ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.

  American journal of physiology. Cell physiology 20060901

• Bleomycin is a potent small-molecule inhibitor of hepatitis C virus replication.

  Chembiochem : a European journal of chemical biology 20060901

• 25-Hydroxycholesterol has a dual effect on the proliferation of cultured rat astrocytes.

  Neuropharmacology 20060801

• RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion.

  Apoptosis : an international journal on programmed cell death 20060701

• Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

  Biochimica et biophysica acta 20060701

• Seasonal variation in calcitropic hormones and bone accrual in puberty.

  The British journal of nutrition 20060701

• Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells.

  Biochemical and biophysical research communications 20060630

• Formation of cholesterol oxidation products in marinated foods during heating.

  Journal of agricultural and food chemistry 20060628

• Synthesis of ent-25-hydroxycholesterol.

  Steroids 20060601

• Localization of StarD5 cholesterol binding protein.

  Journal of lipid research 20060601

• HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs.

  Lipids 20060601

• A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2.

  FEBS letters 20060515

• Phase behavior of lipid monolayers containing DPPC and cholesterol analogs.

  Biophysical journal 20060501

• Identification of a novel sulfonated oxysterol, 5-cholesten-3beta,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria.

  Journal of lipid research 20060501

• Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development.

  The Journal of steroid biochemistry and molecular biology 20060501

• Cholesterol, LDL, and 25-hydroxycholesterol regulate expression of the steroidogenic acute regulatory protein in microvascular endothelial cell line (bEnd.3).

  Biochemical and biophysical research communications 20060421

• Apoptotic effects of 25-hydroxycholesterol in immature rat Sertoli cells: prevention by 17beta-estradiol.

  Reproductive toxicology (Elmsford, N.Y.) 20060401

• Discovery and optimization of a novel series of liver X receptor-alpha agonists.

  Bioorganic & medicinal chemistry letters 20060315

• Analysis of oxysterols by electrospray tandem mass spectrometry.

  Journal of the American Society for Mass Spectrometry 20060301

• Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism.

  Cellular microbiology 20060301

• The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201

• Expression and localization of PCSK9 in rat hepatic cells.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201

• Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages.

  Bulletin of experimental biology and medicine 20060201

• Physiologic interactions between macrophages and Leydig cells.

  Experimental biology and medicine (Maywood, N.J.) 20060101

• Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.

  Cell metabolism 20060101

• Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels.

  BMC biochemistry 20060101

• Receptor Ck-dependent signaling regulates hTERT gene transcription.

  BMC cell biology 20060101

• Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs.

  BMC neuroscience 20060101

• Oxidized LDL, a critical factor in atherogenesis.

  Cardiovascular research 20051201

• Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2).

  Inflammation 20051201

• Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.

  Biochemical and biophysical research communications 20050902

• Sterol structure determines miscibility versus melting transitions in lipid vesicles.

  Biophysical journal 20050901

• Structural mechanism for sterol sensing and transport by OSBP-related proteins.

  Nature 20050901

• Human StarD5, a cytosolic StAR-related lipid binding protein.

  Journal of lipid research 20050801

• Is C-26 hydroxylation an evolutionarily conserved steroid inactivation mechanism?

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801

• Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP.

  Genes to cells : devoted to molecular & cellular mechanisms 20050801

• Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.

  The Journal of biological chemistry 20050715

• Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

  The Journal of biological chemistry 20050701

• Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells.

  The Chinese journal of physiology 20050630

• Cholesterol modulates human intestinal sodium-dependent bile acid transporter.

  American journal of physiology. Gastrointestinal and liver physiology 20050501

• Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules.

  Atherosclerosis 20050501

• In vivo and in vitro exposures of carp and carp tissues to graded concentrations of endocrine disrupting chemicals.

  Annals of the New York Academy of Sciences 20050401

• A new LC/APCI-MS method for the determination of cholesterol oxidation products in food.

  Journal of chromatography. A 20050304

• Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols.

  Cell biology and toxicology 20050301

• Post-transcriptional regulation of apoC-I synthesis and secretion in human HepG2 cells.

  Atherosclerosis 20050201

• Differential effects of mixtures of cholesterol oxidation products on bovine aortic endothelial cells and human monocytic U937 cells.

  International journal of toxicology 20050101

• Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs.

  The Journal of biological chemistry 20041210

• Translocation of phospholipase A2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation.

  Biochimica et biophysica acta 20041108

• Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum.

  The Journal of biological chemistry 20041105

• The influence of the amino acid substitution I98K on the catalytic activity of baboon cytochrome P450 side-chain cleavage (CYP11A1).

  Endocrine research 20041101

• Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products.

  Circulation research 20041015

• Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis.

  Circulation research 20040903

• Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.

  The Journal of biological chemistry 20040820

• Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).

  Biochemical and biophysical research communications 20040806

• Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

  Arteriosclerosis, thrombosis, and vascular biology 20040801

• 25-hydroxycholesterol acts in the Golgi compartment to induce degradation of tyrosinase.

  Pigment cell research 20040801

• The effect of LXR activators on AP-1 proteins in keratinocytes.

  The Journal of investigative dermatology 20040701

• Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.

  Analytical biochemistry 20040601

• Rat cytochrome P450C24 (CYP24A1) and the role of F249 in substrate binding and catalytic activity.

  Archives of biochemistry and biophysics 20040515

• Sterol regulation of scavenger receptor class B type I in macrophages.

  Journal of lipid research 20040501

• Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.

  Journal of cellular biochemistry 20040401

• Oxysterols regulate expression of the steroidogenic acute regulatory protein.

  Journal of molecular endocrinology 20040401

• Effect of LPS on basal and induced apo E secretion by 25-OH chol and 9cRA in differentiated CaCo-2.

  Journal of cellular biochemistry 20040301

• Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity.

  The Journal of biological chemistry 20040220

• Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents.

  The Journal of steroid biochemistry and molecular biology 20040201

• AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis.

  The Journal of biological chemistry 20040109

• CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20040101

• NFY interacts with the promoter region of two genes involved in the rat peroxisomal fatty acid beta-oxidation: the multifunctional protein type 1 and the 3-ketoacyl-CoA B thiolase.

  Lipids in health and disease 20040101

• Analysis of cholesterol oxidation products in biological samples.

  Journal of AOAC International 20040101

• Inhibitory effects of red wine extracts on endothelial-dependent adhesive interactions with monocytes induced by oxysterols.

  Biological research 20040101

• Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells.

  Journal of cellular biochemistry 20031215

• Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases.

  Experimental cell research 20031210

• Steroid structural requirements for stabilizing or disrupting lipid domains.

  Biochemistry 20031209

• Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells.

  The Biochemical journal 20031201

• Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20031201

• Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach.

  Analytical biochemistry 20031201

• In vivo implants of beta-sitosterol cause reductions of reactive cholesterol pools in mitochondria isolated from gonads of male goldfish (Carassius auratus).

  General and comparative endocrinology 20031201

• Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation.

  The Tohoku journal of experimental medicine 20031201

• Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.

  Free radical biology & medicine 20031015

• 7-ketocholesterol stimulates differentiation of lens epithelial cells.

  Molecular vision 20031006

• Origin of oxysterols in hepatic bile of patients with biliary infection.

  The American journal of gastroenterology 20031001

• Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages.

  Atherosclerosis 20031001

• Direct effect of propylthiouracil on progesterone release in rat granulosa cells.

  British journal of pharmacology 20030802

• On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.

  Journal of lipid research 20030801

• Regulation of PPAR-gamma gene in human promyelocytic HL-60 cell line.

  Leukemia research 20030801

• Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo.

  Experimental dermatology 20030801

• NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.

  The Journal of biological chemistry 20030711

• Oxysterols suppress constitutive fibrinogen expression.

  Thrombosis and haemostasis 20030701

• Sterol-mediated regulation of hormone-sensitive lipase in 3T3-L1 adipocytes.

  Lipids 20030701

• Oxysterol-induced toxicity in R28 and ARPE-19 cells.

  Neurochemical research 20030601

• PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.

  Journal of the American Society of Nephrology : JASN 20030301

• Seasonal alterations in adrenocortical cell function associated with stress-responsiveness and sex in the eastern fence lizard (Sceloporus undulatus).

  Hormones and behavior 20030301

• Effects of dioxin (2,3,7,8-TCDD) and PCDDs/PCDFs congeners mixture on steroidogenesis in human placenta tissue culture.

  Endocrine regulations 20030301

• Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients.

  The Journal of biological chemistry 20030221

• Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line.

  Life sciences 20030207

• Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

  The Journal of investigative dermatology 20030201

• Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes.

  Cellular signalling 20030101

• Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells: modulatory effects of alpha- and gamma-tocopherol.

  Journal of applied toxicology : JAT 20030101

• Cholesterol transport and steroidogenesis by the corpus luteum.

  Reproductive biology and endocrinology : RB&E 20030101

• On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

  Journal of lipid research 20021201

• Testosterone regulates 25-hydroxycholesterol production in testicular macrophages.

  Biology of reproduction 20021101

• Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA.

  The Journal of biological chemistry 20021004

• Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis.

  The British journal of nutrition 20021001

• Inhibition of testosterone production by propylthiouracil in rat Leydig cells.

  Biology of reproduction 20020801

• Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.

  Molecular cell 20020801

• Effect of oxysterols on hematopoietic progenitor cells.

  Experimental hematology 20020701

• 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells.

  Archives of biochemistry and biophysics 20020615

• Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.

  The Journal of biological chemistry 20020607

• Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.

  Gastroenterology 20020601

• Characterization of the estrogenic response to genistein in Japanese medaka (Oryzias latipes).

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601

• Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro.

  Experimental & molecular medicine 20020531

• 25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro.

  Biology of reproduction 20020501

• 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles.

  Journal of lipid research 20020501

• The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus).

  General and comparative endocrinology 20020501

• Cholesterol, hydroxycholesterols, and bile acids.

  Biochemical and biophysical research communications 20020419

• Modulation of goldfish testicular testosterone production in vitro by tumor necrosis factor alpha, interleukin-1beta, and macrophage conditioned media.

  The Journal of experimental zoology 20020401

• Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats.

  Bioscience, biotechnology, and biochemistry 20020401

• A Link between cholesterol levels and phenobarbital induction of cytochromes P450.

  Biochemical and biophysical research communications 20020222

• Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments.

  The Biochemical journal 20020201

• Cellular antioxidant effects of atorvastatin in vitro and in vivo.

  Arteriosclerosis, thrombosis, and vascular biology 20020201

• Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements.

  The Journal of biological chemistry 20020125

• Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells.

  Biochemical and biophysical research communications 20020125

• Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol.

  Journal of lipid research 20020101

• Oxysterols induce interleukin-1beta production in human macrophages.

  European journal of clinical investigation 20020101

• Selective effect of cholesterylphosphoserine on intracellular cholesterol transport.

  Lipids 20020101

• Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells.

  Molecular and cellular biochemistry 20020101

• The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells.

  BMC complementary and alternative medicine 20020101

• Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system.

  Journal of biochemistry 20011201

• The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols.

  The Journal of biological chemistry 20011130

• Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.

  The Journal of biological chemistry 20011130

• 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells.

  Atherosclerosis 20011101

• Growth modulation of low density lipoprotein receptor sterol sensitivity in cultured human fibroblasts.

  Lipids 20011101

• Molecular cloning and structural analysis of human sterol C5 desaturase.

  Biochimica et biophysica acta 20011031

• Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading.

  Atherosclerosis 20011001

• Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol.

  Journal of lipid research 20011001

• Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells.

  Journal of lipid research 20011001

• 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages.

  Atherosclerosis 20010901

• Binding and uptake of chylomicron remnants by primary and THP-1 human monocyte-derived macrophages: determination of binding proteins.

  Clinical science (London, England : 1979) 20010801

• [Studies on the mechanism of arterial in vitro calcification].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20010801

• Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster.

  Molecular and cellular endocrinology 20010705

• Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways.

  Endocrinology 20010701

• Fatty acid modifications and cholesterol oxidation in pork loin during frying at different temperatures.

  Journal of food protection 20010701

• Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation.

  The Journal of biological chemistry 20010629

• Plant sterols regulate rat vascular smooth muscle cell growth and prostacyclin release in culture.

  Prostaglandins, leukotrienes, and essential fatty acids 20010601

• Stimulatory effect of lactate on testosterone production by rat Leydig cells.

  Journal of cellular biochemistry 20010601

• Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport.

  The Journal of biological chemistry 20010525

• Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins.

  Free radical research 20010501

• An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture.

  Biochimica et biophysica acta 20010430

• Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells.

  Biochemistry 20010417

• cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate.

  The Biochemical journal 20010415

• Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols.

  Atherosclerosis 20010401

• Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations.

  Journal of lipid research 20010401

• Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells.

  British journal of pharmacology 20010401

• Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.

  Journal of medicinal chemistry 20010315

• Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells.

  American journal of physiology. Cell physiology 20010301

• Production of 25-hydroxycholesterol by testicular macrophages and its effects on Leydig cells.

  Biology of reproduction 20010301

• Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2.

  Cell biochemistry and function 20010301

• Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions.

  The Biochemical journal 20010201

• Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro.

  Acta veterinaria Hungarica 20010101

• Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols.

  Cell biology and toxicology 20010101

• Control of apolipoprotein E secretion by 25-hydroxycholesterol and proinflammatory cytokines in the human astrocytoma cell line CCF-STTG1.

  Cell biology and toxicology 20010101

• Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death.

  BMC pharmacology 20010101

• Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A).

  The Journal of biological chemistry 20001103

• Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.

  The Journal of biological chemistry 20000602

• The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol.

  Biochemical and biophysical research communications 20000402

• Down-regulation of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with highly purified liposomal cholesterol.

  European journal of biochemistry 19991201

• Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions.

  The Journal of biological chemistry 19981113

• Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro.

  Antiviral chemistry & chemotherapy 19981101

• Meiosis-activating sterol promotes resumption of meiosis in mouse oocytes cultured in vitro in contrast to related oxysterols.

  Biology of reproduction 19980501

• Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.

  Proceedings of the National Academy of Sciences of the United States of America 19970513

• Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase.

  Biochimica et biophysica acta 19970218

• Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.

  The Journal of biological chemistry 19970207

• Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages.

  The Journal of clinical investigation 19960115

• Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes.

  Arteriosclerosis, thrombosis, and vascular biology 19950301

• Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis.

  Journal of lipid research 19950201

• 7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase.

  European journal of biochemistry 19940901

• Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages.

  Proceedings of the National Academy of Sciences of the United States of America 19940830

• 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver.

  Biochimica et biophysica acta 19930224