2140-71-8 | 2'-O-Methylguanosine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$6.00	$4.00
100mg	98%	in stock	$11.00	$8.00
250mg	98%	in stock	$23.00	$17.00
1g	98%	in stock	$61.00	$43.00
5g	98%	in stock	$259.00	$182.00

Description

• Catalog Number: AF35818
• Chemical Name: 2'-O-Methylguanosine
• CAS Number: 2140-71-8
• Molecular Formula: C11H15N5O5
• Molecular Weight: 297.2673
• MDL Number: MFCD00057053
• SMILES: CO[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1nc(N)[nH]c2=O)CO

Computed Properties

• Complexity: 460
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 3
• XLogP3: -1.4

Literature

• Facile and efficient approach for the synthesis of N(2)-dimethylaminomethylene-2'-O-methylguanosine.

  Bioorganic & medicinal chemistry letters 20100101

• The thermodynamics of 3'-terminal pyrene and guanosine for the design of isoenergetic 2'-O-methyl-RNA-LNA chimeric oligonucleotide probes of RNA structure.

  Biochemistry 20080205

• Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling.

  BMC biochemistry 20070101

• An efficient process for synthesis of 2'-O-methyl and 3'-O-methyl guanosine from 2-aminoadenosine using diazomethane and the catalyst stannous chloride.

  Nucleosides, nucleotides & nucleic acids 20060301

• A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B.

  The Journal of biological chemistry 20050225

• Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.

  Journal of medicinal chemistry 20050224

• Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.

  Journal of medicinal chemistry 20040422

• Novel synthesis of 2'-O-methylguanosine.

  Bioorganic & medicinal chemistry letters 20030519

• Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs.

  The Journal of antimicrobial chemotherapy 20030401

• MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines.

  Nucleosides, nucleotides & nucleic acids 20030101

• Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs.

  Genes to cells : devoted to molecular & cellular mechanisms 20020301

• Anticodon domain methylated nucleosides of yeast tRNA(Phe) are significant recognition determinants in the binding of a phage display selected peptide.

  Biochemistry 20011127