2140-76-3 | 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$6.00	$5.00
5g	98%	in stock	$14.00	$10.00
10g	98%	in stock	$26.00	$19.00
25g	98%	in stock	$61.00	$43.00
100g	98%	in stock	$195.00	$136.00

Description

• Catalog Number: AB49959
• Chemical Name: 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS Number: 2140-76-3
• Molecular Formula: C10H14N2O6
• Molecular Weight: 258.228
• MDL Number: MFCD00056054
• SMILES: CO[C@@H]1[C@H](O)[C@H](O[C@H]1n1ccc(=O)[nH]c1=O)CO

Computed Properties

• Complexity: 385
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -1.4

Literature

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  Biochemistry 20091124

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  The journal of physical chemistry. A 20080207

• Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs.

  Biochemical and biophysical research communications 20070914

• Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides.

  Bioorganic & medicinal chemistry 20051215

• Design and studies of novel 5-substituted alkynylpyrimidine nucleosides as potent inhibitors of mycobacteria.

  Journal of medicinal chemistry 20051103

• A specific substrate-inhibitor, a 2'-deoxy-2'-fluorouridine-containing oligoribonucleotide, against human RNase L.

  Bioorganic & medicinal chemistry 20031117

• 2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.

  Biochemistry 20021001