2140-79-6 | 2'-O-Methyladenosine

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$12.00	$9.00
250mg	98%	in stock	$18.00	$13.00
1g	98%	in stock	$34.00	$24.00
5g	98%	in stock	$103.00	$72.00
25g	98%	in stock	$511.00	$358.00
100g	98%	in stock	$1,536.00	$1,075.00

Description

• Catalog Number: AB44201
• Chemical Name: 2'-O-Methyladenosine
• CAS Number: 2140-79-6
• Molecular Formula: C11H15N5O4
• Molecular Weight: 281.2679
• MDL Number: MFCD00056002
• SMILES: CO[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N)CO

Computed Properties

• Complexity: 349
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -0.5

Literature

• 2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase.

  PLoS pathogens 20120401

• Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The Pd(2+) Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside.

  Journal of nucleic acids 20120101

• Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.

  BMC plant biology 20100101

• Modifications in small interfering RNA that separate immunostimulation from RNA interference.

  Journal of immunology (Baltimore, Md. : 1950) 20080301

• RNA analysis by MEKC with LIF detection.

  Electrophoresis 20071101

• Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands.

  Bioorganic & medicinal chemistry 20070815

• Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.

  Journal of medicinal chemistry 20070809

• Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity.

  Virology journal 20050101

• Acidity of secondary hydroxyls in ATP and adenosine analogues and the question of a 2',3'-hydrogen bond in ribonucleosides.

  Journal of the American Chemical Society 20041117

• Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.

  Journal of medicinal chemistry 20040422

• Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection.

  RNA (New York, N.Y.) 20030801

• The role of magnesium ions and 2'-hydroxyl groups in the VS ribozyme-substrate interaction.

  Journal of molecular biology 20021122

• Antiviral activity of O'-methylated derivatives of adenine arabinoside.

  Biochemical pharmacology 19770415