2174-59-6 | 5-O-Demethylnobiletin

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$110.00	$77.00
5mg	98%	in stock	$313.00	$219.00
10mg	≥98%	in stock	$543.00	$380.00
25mg	≥98%	in stock	$1,219.00	$854.00
50mg	98%	in stock	$2,175.00	$1,522.00
100mg	98%	in stock	$3,874.00	$2,712.00

Description

• Catalog Number: AF33457
• Chemical Name: 5-O-Demethylnobiletin
• CAS Number: 2174-59-6
• Molecular Formula: C20H20O8
• Molecular Weight: 388.3680
• MDL Number: MFCD08458849
• SMILES: COc1cc(ccc1OC)c1cc(=O)c2c(o1)c(OC)c(c(c2O)OC)OC
• NSC Number: 618927

Computed Properties

• Complexity: 579
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 3.2

Literature

• Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.

  Toxicology letters 20180915

• B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.

  Bioorganic & medicinal chemistry 20111201

• The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones.

  Molecular nutrition & food research 20110401

• Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells.

  Molecular nutrition & food research 20100701

• Constituents of Calamintha ashei: effects on Florida sandhill species.

  Natural product communications 20100501

• [Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography].

  Se pu = Chinese journal of chromatography 20100401

• Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection.

  Journal of chromatography. A 20100129

• Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection.

  Journal of agricultural and food chemistry 20090812

• [Reparative isolation and purification of flavones from Pericarpium Citri Reticulatae by high-speed counter-current chromatography].

  Se pu = Chinese journal of chromatography 20090301

• Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.

  Bioorganic & medicinal chemistry 20090101

• Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells.

  Bioorganic & medicinal chemistry 20080315

• Demethylnobiletin inhibits delayed-type hypersensitivity reactions, human lymphocyte proliferation and cytokine production.

  British journal of pharmacology 20071201

• Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.

  Bioorganic & medicinal chemistry 20070515

• Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography.

  Journal of chromatography. A 20051007

• Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells.

  Bioscience, biotechnology, and biochemistry 20050101