2192-20-3 | Hydroxyzine dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$26.00	$18.00
5g	97%	in stock	$58.00	$41.00
25g	97%	in stock	$163.00	$114.00
100g	97%	in stock	$473.00	$331.00
500g	97%	in stock	$1,536.00	$1,075.00

Description

• Catalog Number: AI45129
• Chemical Name: Hydroxyzine dihydrochloride
• CAS Number: 2192-20-3
• Molecular Formula: C21H29Cl3N2O2
• Molecular Weight: 447.8262
• MDL Number: MFCD00058200
• SMILES: OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1.Cl.Cl

Computed Properties

• Complexity: 376
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 8
• Undefined Atom Stereocenter Count: 1

Literature

• Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine.

  Antimicrobial agents and chemotherapy 20140601

• Understanding the pharmacokinetics of anxiolytic drugs.

  Expert opinion on drug metabolism & toxicology 20130401

• Two-step liquid phase microextraction combined with capillary electrophoresis: a new approach to simultaneous determination of basic and zwitterionic compounds.

  Journal of separation science 20120801

• Non-opioid drugs for pain management in labour.

  The Cochrane database of systematic reviews 20120711

• Assessing the removal of pharmaceuticals and personal care products in a full-scale activated sludge plant.

  Environmental science and pollution research international 20120601

• Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice.

  Journal of anesthesia 20120601

• LSD screening in urine performed by CEDIA® LSD assay: positive interference with sertraline.

  Journal of analytical toxicology 20120501

• Sedation of children undergoing dental treatment.

  The Cochrane database of systematic reviews 20120314

• Double-blind placebo-controlled evaluation of the PROMETA™ protocol for methamphetamine dependence.

  Addiction (Abingdon, England) 20120201

• Treatment strategies of obsessive-compulsive disorder and panic disorder/agoraphobia.

  Current topics in medicinal chemistry 20120101

• Hydroxyzine, cimetidine and vitamin C in reducing skin flap necrosis in ischemia-reperfusion injury in rats. A comparative study.

  Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20120101

• Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers.

  Journal of psychopharmacology (Oxford, England) 20111101

• [Bradykinin-mediated angioedema secondary to angiotensin converting enzyme: initiate treatment from the prehospital phase].

  Annales francaises d'anesthesie et de reanimation 20111101

• Nodular scabies: hypersensitivity reaction or infection?

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20111001

• In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery.

  AAPS PharmSciTech 20110901

• Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.

  European journal of anaesthesiology 20110901

• A fatality due to an accidental methadone substitution in a dental cocktail.

  Journal of analytical toxicology 20110901

• Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.

  Acta pharmacologica Sinica 20110901

• Lack of preventing effect of systemically and topically administered histamine H(1) or H(4) receptor antagonists in a dog model of acute atopic dermatitis.

  Experimental dermatology 20110701

• Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers.

  Journal of clinical psychopharmacology 20110601

• Sorption of emerging trace organic compounds onto wastewater sludge solids.

  Water research 20110501

• Chiral separation and quantitation of cetirizine and hydroxyzine by maltodextrin-mediated CE in human plasma: effect of zwitterionic property of cetirizine on enantioseparation.

  Electrophoresis 20110301

• Annular groin eruptions: pityriasis rosea of vidal.

  International journal of dermatology 20110201

• Primary dermatologic findings with early-onset intrahepatic cholestasis of pregnancy.

  Obstetrics and gynecology 20110201

• Bispectral index monitoring of sedation depth in pediatric dental patients.

  Anesthesia progress 20110101

• Generalised anxiety disorder.

  BMJ clinical evidence 20110101

• Hydroxyzine for generalised anxiety disorder.

  The Cochrane database of systematic reviews 20101208

• The importance of taking a history of over-the-counter medication use: a brief review and case illustration of 'PRN' antihistamine dependence in a hospitalized adolescent.

  Journal of child and adolescent psychopharmacology 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Prevention of nausea and vomiting during termination of pregnancy.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20101001

• Delayed recrudescence to toxic salicylate concentrations after salsalate overdose.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20100601

• The effects of single dose anxiolytic medication on the CO2 models of anxiety: differentiation of subjective and objective measures.

  Journal of psychopharmacology (Oxford, England) 20100501

• Moderate sedation for echocardiography of preschoolers.

  Pediatric cardiology 20100501

• Hydroxyzine hydrochloride in familial restless legs syndrome.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100501

• Clinical reasoning: seizures in a child with sensorineural deafness and agitation.

  Neurology 20100413

• Effectiveness of premedication agents administered prior to nitrous oxide/oxygen.

  European journal of anaesthesiology 20100401

• Chorea induced by antihistamine drugs.

  Movement disorders : official journal of the Movement Disorder Society 20100315

• [Skin rash on an infant].

  Actas dermo-sifiliograficas 20100301

• Hydroxyzine and cetirizine interfere with the PENTINA carbamazepine assay but not with the ADVIA CENTEUR carbamazepine assay.

  Therapeutic drug monitoring 20100201

• Dapsone hypersensitivity syndrome during delayed pressure urticaria treatment.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20100201

• Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H.

  International archives of allergy and immunology 20100101

• Comparative evaluation of antipruritic protocols in acute burns. The emerging value of gabapentin in the treatment of burns pruritus.

  Journal of burn care & research : official publication of the American Burn Association 20100101

• Papuloerythroderma 2009: two new cases and systematic review of the worldwide literature 25 years after its identification by Ofuji et al.

  Dermatology (Basel, Switzerland) 20100101

• [Comparative characteristics of hydroxyzine (atarax) and diazepam in the premedication regimen in children in dental practice].

  Anesteziologiia i reanimatologiia 20100101

• Analytical performance evaluation of ADVIA Chemistry Carbamazepine_2 assay: minimal cross-reactivity with carbamazepine 10, 11-epoxide and none with hydroxyzine or cetirizine.

  Journal of clinical laboratory analysis 20100101

• Dose dependency of brain histamine H(1) receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin.

  Human psychopharmacology 20091001

• Effects of dexamethasone and hydroxyzine treatment on intradermal testing and allergen-specific IgE serum testing results in horses.

  Veterinary dermatology 20091001

• Anaphylactic reaction to hydroxyzine in an anesthetized patient.

  European annals of allergy and clinical immunology 20090801

• Triprotic acid-base microequilibria and pharmacokinetic sequelae of cetirizine.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628

• Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20090601

• What the first 10,000 patients with chronic urticaria have taught me: a personal journey.

  The Journal of allergy and clinical immunology 20090301

• Efficacy of leukotriene receptor antagonist with an anti-H1 receptor antagonist for treatment of chronic idiopathic urticaria.

  The Journal of dermatological treatment 20090101

• Metoprolol succinate therapy associated with erythema multiforme.

  Cardiology journal 20090101

• Interstitial cystitis.

  Medicine and health, Rhode Island 20090101

• Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment.

  Drugs 20090101

• Experience with cyclosporine in children with chronic idiopathic urticaria.

  Pediatric dermatology 20090101

• Multimodal therapy for painful bladder syndrome / interstitial cystitis: pilot study combining behavioral, pharmacologic, and endoscopic therapies.

  International braz j urol : official journal of the Brazilian Society of Urology 20090101

• Stevens-Johnson syndrome: a case report.

  Allergologia et immunopathologia 20090101

• Effect on behavior of dental treatment rendered under conscious sedation and general anesthesia in pediatric patients.

  Pediatric dentistry 20090101

• Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs.

  Veterinary dermatology 20081201

• Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments.

  Journal of clinical psychopharmacology 20081201

• Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.

  Journal of pharmacological sciences 20081201

• Anticholinergic esotropia.

  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20081201

• Conscious sedation in the critically ill ventilated patient.

  Journal of critical care 20080901

• Treatment of chronic autoimmune urticaria with omalizumab.

  The Journal of allergy and clinical immunology 20080901

• Treatment modalities, health care resource utilization, and costs in patients diagnosed with interstitial cystitis.

  American journal of obstetrics and gynecology 20080701

• [The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment].

  Aktuelle Urologie 20080701

• Molecularly imprinted polymer based potentiometric sensor for the determination of hydroxyzine in tablets and biological fluids.

  Analytica chimica acta 20080331

• Knowledge of pharmacists regarding ritalin and ADHD and their attitude towards the use of ritalin to treat ADHD.

  International journal of clinical pharmacology and therapeutics 20080201

• Development of a voltammetric procedure for assay of the antihistamine drug hydroxyzine at a glassy carbon electrode: Quantification and pharmacokinetic studies.

  Talanta 20080115

• Exudative erythema multiforme induced by hydroxyzine.

  European journal of dermatology : EJD 20080101

• Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine.

  Current medicinal chemistry 20080101

• Concurrent use of anticholinergic drugs and cholinesterase inhibitors: register-based study of over 700,000 elderly patients.

  Drugs & aging 20080101

• Perioperative management of obstructive sleep apnea with nasal continuous positive airway pressure.

  Anesthesia progress 20080101

• [Pruritic urticarial papules and plaques of pregnancy].

  Akusherstvo i ginekologiia 20080101

• Worsening of atopic dermatitis by hazelnut essence contained in hydroxyzine syrup.

  Acta paediatrica (Oslo, Norway : 1992) 20071101

• Unusual adulterants in cocaine seized on Italian clandestine market.

  Forensic science international 20071025

• Precolumn fluorescence labeling method for simultaneous determination of hydroxyzine and cetirizine in human serum.

  Biomedical chromatography : BMC 20071001

• Open-label study of a proprietary treatment program targeting type A gamma-aminobutyric acid receptor dysregulation in methamphetamine dependence.

  Mayo Clinic proceedings 20071001

• Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE.

  Electrophoresis 20070801

• Depressive symptoms in urticaria patients treated with first- or second-generation histamine 1 receptor antagonists.

  Journal of clinical psychopharmacology 20070801

• A case of urticaria induced by both hydroxyzine and cetirizine but not by levocetirizine.

  Allergy 20070701

• Lack of effects between rupatadine 10 mg and placebo on actual driving performance of healthy volunteers.

  Human psychopharmacology 20070701

• Interstitial cystitis/painful bladder syndrome.

  Urologic nursing 20070601

• The experience of childbrith in first-time mothers who received narcotic analgesics during the first stage of labour.

  Curationis 20070601

• Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial.

  The American journal of gastroenterology 20070401

• Rational approaches to the treatment of patients with interstitial cystitis.

  Urology 20070401

• Acute episode or chronic problem?

  JAAPA : official journal of the American Academy of Physician Assistants 20070401

• Sulpiride plus hydroxyzine decrease tinnitus perception.

  Auris, nasus, larynx 20070301

• [Hydroxyzine premedication does not alter bispectral index changes following etomidate induction of general anaesthesia].

  Annales francaises d'anesthesie et de reanimation 20070301

• False-positive serum tricyclic antidepressant concentrations using fluorescence polarization immunoassay due to the presence of hydroxyzine and cetirizine.

  Therapeutic drug monitoring 20070201

• Comparison of hydroxyzine and doxepin in treatment of pruritus due to sulfur mustard.

  Skinmed 20070101

• Turbidimetric carbamazepine immunoassay on the ADVIA 1650 and 2400 analyzers is free from interference of antihistamine drugs hydroxyzine and cetirizine.

  Journal of clinical laboratory analysis 20070101

• The painful bladder: urinary tract infection and interstitial cystitis in women.

  Missouri medicine 20070101

• Comparison of three conscious sedation regimens for pediatric dental patients.

  The Journal of clinical pediatric dentistry 20070101

• Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial.

  Cutaneous and ocular toxicology 20070101

• Study of the EEG changes during the combined ingestion of alcohol and H1-antihistamines by using the wavelet transform.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20070101

• A randomized double-blinded trial of chloral hydrate with or without hydroxyzine versus placebo for pediatric dental sedation.

  Brazilian dental journal 20070101

• [Use of anxiolytic atarax as a substitutive drug for benzodiazepine tranquilizers].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• [The use of atarax in the treatment of attention deficit syndrome with hyperactivity and anxiety].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• Interdisciplinary approach to endodontic therapy for uncooperative children in a dental school environment.

  Journal of dental education 20061201

• Trichotillomania: a treatment overview.

  The Journal of practical nursing 20061201

• False-positive serum tricyclic antidepressant concentrations using fluorescence polarization immunoassay due to the presence of hydroxyzine and cetirizine.

  Therapeutic drug monitoring 20061001

• Skin tears?

  The American journal of medicine 20060801

• Severe cholinergic urticaria successfully treated with scopolamine butylbromide in addition to antihistamines.

  Clinical and experimental dermatology 20060701

• Skin reaction to hydroxyzine (Atarax): patch test utility.

  Contact dermatitis 20060401

• Mucosal eosinophilia and response to H1/H2 antagonist and cromolyn therapy in pediatric dyspepsia.

  Clinical pediatrics 20060301

• Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface.

  Biophysical chemistry 20060201

• Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol, in healthy volunteers.

  Human psychopharmacology 20060101

• [A case of drug eruption induced by hydroxyzine pamoate].

  Arerugi = [Allergy] 20060101

• Children sedated for dental care: a pilot study of the 24-hour postsedation period.

  Pediatric dentistry 20060101

• Assessment of the effects of 2 sedation regimens on cardiopulmonary parameters in pediatric dental patients: a retrospective study.

  Pediatric dentistry 20060101

• Survey of sedation techniques used Among pediatric dentists in New York State.

  The New York state dental journal 20060101

• [The use of atarax in the treatment of tic hyperkinesia in children: a pilot study].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• A prospective study of 2 sedation regimens in children: chloral hydrate, meperidine, and hydroxyzine versus midazolam, meperidine, and hydroxyzine.

  Anesthesia progress 20060101

• Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine.

  Journal of neural transmission. Supplementum 20060101

• Patient response in a screened population for interstitial cystitis.

  Comprehensive therapy 20060101

• Generalised anxiety disorder.

  Clinical evidence 20051201

• Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use.

  Human psychopharmacology 20051001

• Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules.

  International journal of pharmaceutics 20050930

• Bradycardia and hypertension in anticipation of, and exacerbated by, peribulbar block: a prospective audit.

  Acta anaesthesiologica Scandinavica 20050901

• Tracheal intubation in routine practice with and without muscular relaxation: an observational study.

  European journal of anaesthesiology 20050901

• Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column.

  Journal of chromatography. A 20050812

• Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (PETINIA).

  Therapeutic drug monitoring 20050801

• Interstitial cystitis: a primary care perspective.

  Cleveland Clinic journal of medicine 20050801

• Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050501

• Perioral angioedema associated with angiotensin-converting enzyme inhibitor.

  Journal of periodontology 20050401

• Sedation in the critically ill ventilated patient: possible role of enteral drugs.

  Intensive care medicine 20050301

• Hydroxyzine- and cetirizine-loaded liposomes: effect of duration of thin film hydration, freeze-thawing, and changing buffer pH on encapsulation and stability.

  Drug development and industrial pharmacy 20050301

• [Methadone and sleep apnea syndrome].

  Canadian journal of psychiatry. Revue canadienne de psychiatrie 20050301

• Observations of the 'carry-over effect' following successful termination of chronic migraine in the adolescent with short-term dihydroergotamine, dexamethasone and hydroxyzine: a pilot study.

  The journal of headache and pain 20050201

• [A case of catatonia associated with the ingestion of hydroxyzine].

  No to shinkei = Brain and nerve 20050101

• [Therapeutic options in idiopathic chronic urticaria].

  Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20050101

• Comparison of chloral hydrate, meperidine, and hydroxyzine to midazolam regimens for oral sedation of pediatric dental patients.

  Pediatric dentistry 20050101

• [A comparative study of the effect of brazidole, amiodarone, sotalol, and hydroxyzine on potassium ionic channels of mollusks neurons].

  Eksperimental'naia i klinicheskaia farmakologiia 20050101

• Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy.

  Reproductive toxicology (Elmsford, N.Y.) 20050101

• A pilot, open label, clinical trial using hydroxyzine in multiple sclerosis.

  International journal of immunopathology and pharmacology 20050101

• Pityriasis rosea-like eruptions due to mustard oil application.

  Indian journal of dermatology, venereology and leprology 20050101

• Generalised anxiety disorder.

  Clinical evidence 20041201

• Hydroxyzine prevents isolation-induced vocalization in guinea pig pups: comparison with chlorpheniramine and immepip.

  Pharmacology, biochemistry, and behavior 20040901

• Ropivacaine-induced asystole: 'never again' rather than 'here we go again'.

  Anesthesiology 20040801

• Cutaneous drug eruption from cetirizine and hydroxyzine.

  Journal of the American Academy of Dermatology 20040601

• Premedications and peribulbar analgesia--a prospective audit.

  Middle East journal of anaesthesiology 20040601

• Generalised anxiety disorder.

  Clinical evidence 20040601

• Hydroxyzine-induced supraventricular tachycardia in a nine-year-old child.

  Singapore medical journal 20040201

• [Drugs for the treatment of Alzheimer's disease].

  Nihon rinsho. Japanese journal of clinical medicine 20040101

• A simple high-performance liquid chromatographic method for detection of hydroxyzine in human plasma after overdose.

  Journal of pharmacological and toxicological methods 20040101

• Aquagenic urticaria: report of a case.

  Allergy and asthma proceedings 20040101

• Selecting pharmacotherapy for generalized anxiety disorder.

  The Journal of clinical psychiatry 20040101

• [Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor].

  Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101

• Central and peripheral evaluation of rupatadine, a new antihistamine/platelet-activating factor antagonist, at different doses in healthy volunteers.

  Neuropsychobiology 20040101

• Comparison of oral midazolam with and without hydroxyzine in the sedation of pediatric dental patients.

  Pediatric dentistry 20040101

• [Autoimmune urticaria. Treatment with methotrexate].

  Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101

• Psychogenic intractable sneezing: case reports and a review of treatment options.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031201

• Hydroxyzine from topical phospholipid liposomal formulations: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model.

  AAPS pharmSci 20031201

• P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

  Journal of pharmaceutical sciences 20031001

• A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis.

  The Journal of urology 20030901

• Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine, and meclizine by capillary electrophoresis.

  Analytical and bioanalytical chemistry 20030701

• Effects of anti-allergic drugs on intestinal mastocytosis and worm expulsion of rats infected with Neodiplostomum seoulense.

  The Korean journal of parasitology 20030601

• Generalised anxiety disorder.

  Clinical evidence 20030601

• A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car.

  Clinical therapeutics 20030501

• Treating generalised anxiety disorder.

  BMJ (Clinical research ed.) 20030329

• Anxiolysis in general dental practice.

  Dentistry today 20030301

• Hydroxyzine for generalized anxiety disorder.

  The Journal of clinical psychiatry 20030301

• Beef allergy: a review of 12 cases.

  Allergy 20030201

• A randomized, controlled, crossover trial of oral midazolam and hydroxyzine for pediatric dental sedation.

  Pesquisa odontologica brasileira = Brazilian oral research 20030101

• Antibiotic-associated maculopapular reaction.

  The Annals of pharmacotherapy 20021201

• Chronic urticaria and angioedema.

  The New England journal of medicine 20021121

• Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study.

  The Journal of clinical psychiatry 20021101

• [Cutaneous drug eruption with two antihistaminic drugs of a same chemical family: cetirizine and hydroxyzine].

  Annales de dermatologie et de venereologie 20021101

• Premedication from a patient perspective--morphine, midazolam, hydroxyzine and placebo compared.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20020901

• Immediate hypersensitivity reaction associated with the rapid infusion of Crotalidae polyvalent immune Fab (ovine).

  Annals of emergency medicine 20020601

• Gabapentin in complicated school refusal.

  Journal of the American Academy of Child and Adolescent Psychiatry 20020601

• Coma and apnea in a dog with hydroxyzine toxicosis.

  Veterinary and human toxicology 20020201

• Titrimetric and spectrophotometric assay of some antihistamines through the determination of the chloride of their hydrochlorides.

  Farmaco (Societa chimica italiana : 1989) 20020101

• Antihistamines in the management of canine atopic dermatitis: a retrospective study of 171 dogs (1992-1998).

  Veterinary therapeutics : research in applied veterinary medicine 20020101

• Association between bispectral analysis and level of conscious sedation of pediatric dental patients.

  Pediatric dentistry 20020101

• Project USAP 2000--use of sedative agents by pediatric dentists: a 15-year follow-up survey.

  Pediatric dentistry 20020101

• [Carotid endarterectomy under remifentanil].

  Revista espanola de anestesiologia y reanimacion 20011201

• Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs).

  Biochemical pharmacology 20011101

• Adverse events and outcomes of conscious sedation for pediatric patients: study of an oral sedation regimen.

  Journal of the American Dental Association (1939) 20011101

• Three cases of penile edema in peripubescent males.

  Clinical pediatrics 20010901

• Treatment-resistant atopic dermatitis.

  Journal of the American Geriatrics Society 20010701

• Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems.

  Pharmaceutical research 20010501

• [Dyshidrosis and acral purpura during polymorphic dermatitis in pregnancy: 2 cases].

  Annales de dermatologie et de venereologie 20010401

• Effect of hydroxyzine on the transport of etoposide in rat small intestine.

  Anti-cancer drugs 20010301

• Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy.

  European journal of anaesthesiology 20010201

• Pharmacotherapy of generalized anxiety disorder.

  The Journal of clinical psychiatry 20010101

• Pruritus.

  Advances in dermatology 20010101

• Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells.

  Molecular pharmacology 20001101

• Hydroxyzine inhibits neurogenic bladder mast cell activation.

  International journal of immunopharmacology 19981001

• [Benzodiazepine withdrawal presenting as pseudo-surgical abdominal pain].

  Annales francaises d'anesthesie et de reanimation 19970101

• Intranasal midazolam better at effecting amnesia after sedation than oral hydroxyzine: a pilot study.

  Pediatric dentistry 19960101

• Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19950201

• [Modification of cognitive functions by 2 anxiolytic treatments in patients suffering from generalized anxiety].

  L'Encephale 19950101

• Prolonged penile erections induced by hydroxyzine: possible mechanism of action.

  Neuropsychobiology 19940101

• Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria.

  Annals of allergy 19911001

• Direct measurement of daytime sleepiness after administration of cetirizine and hydroxyzine with a standardized electroencephalographic assessment.

  The Journal of allergy and clinical immunology 19901201

• Cetirizine vs astemizole in the treatment of chronic idiopathic urticaria.

  The Journal of international medical research 19900101

• Akathisia associated with droperidol during epidural anesthesia.

  Anesthesiology 19891101

• Prolongation of simple and choice reaction times in a double-blind comparison of twice-daily hydroxyzine versus terfenadine.

  The Journal of allergy and clinical immunology 19890901

• A comparison of acrivastine versus hydroxyzine and placebo in the treatment of chronic idiopathic urticaria.

  The Journal of international medical research 19890101

• Absence of amnesia induction in mice with hydroxyzine in comparison with three other minor tranquillizers.

  Arzneimittel-Forschung 19880401

• Peripheral antihistamine and central sedative effects of three H1-receptor antagonists.

  European journal of clinical pharmacology 19850101

• Opioid drugs cause bile duct obstruction during hepatobiliary scans.

  American journal of surgery 19840101

• Comparative study of midazolam and vesparax in moderate or severe insomnia in female surgical patients.

  British journal of clinical pharmacology 19830101

• Efficacy and safety of midazolam and vesparax in treatment of sleep disorders.

  British journal of clinical pharmacology 19830101

• Hydroxyzine-associated tardive dyskinesia.

  Annals of neurology 19820401

• Hydroxyzine hydrochloride: possible adverse cardiac interactions.

  Psychopharmacology communications 19750101

• Effects of dextroamphetamine, chlorpromazine, and hydroxyzine on behavior and performance in hyperactive children.

  The American journal of psychiatry 19721101

• [Intraspecific aggressive behavior induced by apomorphine in the rat].

  Psychopharmacologia 19700101

• Circulatory and respiratory effects of hydroxyzine in volunteers and geriatric patients.

  Anesthesia and analgesia 19680101

• The effect of SA 97, perphenazine, and hydroxyzine on epinephrine-induced cardiac arrhythmias during methoxyflurane anaesthesia in dogs.

  Canadian Anaesthetists' Society journal 19620101

• Management of emotional disturbances; use of hydroxyzine (atarax) in general practice.

  California medicine 19580601

• Cardiovascular action of hydroxyzine (atarax).

  The Journal of pharmacology and experimental therapeutics 19561201