220904-83-6 | 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$12.00	$9.00
50mg	95%	in stock	$119.00	$83.00
100mg	95%	in stock	$163.00	$114.00
250mg	95%	in stock	$249.00	$174.00

Description

• Catalog Number: AD59612
• Chemical Name: 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
• CAS Number: 220904-83-6
• Molecular Formula: C15H8Br2INO2
• Molecular Weight: 520.9420
• MDL Number: MFCD09971042
• SMILES: Ic1ccc2c(c1)/C(=C/c1cc(Br)c(c(c1)Br)O)/C(=O)N2

Computed Properties

• Complexity: 447
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 4.6

Literature

• Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton.

  Toxicology 20170815

• The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.

  Journal of medicinal chemistry 20130808

• LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.

  Neurobiology of disease 20120901

• Raf-1, a potential therapeutic target, mediates early steps in endometriosis lesion development by endometrial epithelial and stromal cells.

  Endocrinology 20120801

• The Raf-1 inhibitor GW5074 and the ERK1/2 pathway inhibitor U0126 ameliorate PC12 cells apoptosis induced by 6-hydroxydopamine.

  Die Pharmazie 20120801

• Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

  Science translational medicine 20120704

• Pentoxifylline inhibits hepatic stellate cells proliferation via the Raf/ERK pathway.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20120701

• Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2.

  Molecular and biochemical parasitology 20120501

• Secondhand smoke exposure causes bronchial hyperreactivity via transcriptionally upregulated endothelin and 5-hydroxytryptamine 2A receptors.

  PloS one 20120101

• Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.

  Human molecular genetics 20111015

• Signaling cascades mediate astrocyte death induced by zinc.

  Toxicology letters 20110728

• A new approach to Parkinson's disease: inhibition of leucine-rich repeat kinase-2.

  Expert opinion on investigational drugs 20110401

• Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.

  Nature chemical biology 20110201

• Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.

  Biochimie 20101201

• Identification of specific inhibitors for a trypanosomatid RNA editing reaction.

  RNA (New York, N.Y.) 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition.

  Cell cycle (Georgetown, Tex.) 20100815

• Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries.

  Journal of vascular research 20100801

• Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.

  Endocrinology 20100701

• Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways.

  Endocrinology 20100201

• C-Raf is associated with disease progression and cell proliferation in a subset of melanomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090915

• Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.

  The Journal of pharmacology and experimental therapeutics 20090901

• Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics.

  The Journal of biological chemistry 20090821

• Enhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity.

  Cellular signalling 20090501

• Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.

  Experimental & molecular medicine 20090430

• Raf-1: a novel cardiac troponin T kinase.

  Journal of muscle research and cell motility 20090101

• Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells.

  Toxicology and applied pharmacology 20081201

• Raf inhibition protects cortical cells against beta-amyloid toxicity.

  Neuroscience letters 20081017

• Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity.

  The Journal of general virology 20081001

• Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074.

  Journal of neurochemistry 20080501

• Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501

• Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner.

  European journal of pharmacology 20080428

• The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice.

  Respiratory research 20080101

• Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.

  Journal of pharmacological sciences 20070901

• Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells.

  Neuroreport 20061106

• Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway.

  Journal of pharmacological sciences 20061101

• Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.

  European journal of pharmacology 20060701

• Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells.

  Molecular cancer therapeutics 20060301

• Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

  Journal of cellular biochemistry 20060201

• Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells.

  Reproductive biology and endocrinology : RB&E 20060101

• Structural model of the Plasmodium CDK, Pfmrk, a novel target for malaria therapeutics.

  Journal of molecular graphics & modelling 20050901

• Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis.

  Frontiers in bioscience : a journal and virtual library 20050101

• The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.

  Journal of neurochemistry 20040801

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419