22139-77-1 | Pinosylvin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$48.00	$34.00
100mg	98%	in stock	$121.00	$85.00

Description

• Catalog Number: AB47665
• Chemical Name: Pinosylvin
• CAS Number: 22139-77-1
• Molecular Formula: C14H12O2
• Molecular Weight: 212.2439
• MDL Number: MFCD00210544
• SMILES: Oc1cc(/C=C/c2ccccc2)cc(c1)O
• NSC Number: 362430

Computed Properties

• Complexity: 221
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 3.5

Literature

• Suppression of Src/ERK and GSK-3/β-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130501

• The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis.

  Acta pharmacologica Sinica 20121001

• Antimetastatic activity of pinosylvin, a natural stilbenoid, is associated with the suppression of matrix metalloproteinases.

  The Journal of nutritional biochemistry 20120801

• Resveratrol as a kcat type inhibitor for tyrosinase: potentiated melanogenesis inhibitor.

  Bioorganic & medicinal chemistry 20120115

• Bioactivity guided isolation of anticancer constituents from leaves of Alnus sieboldiana (Betulaceae).

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415

• Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids.

  Journal of agricultural and food chemistry 20110309

• Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.

  Bioorganic & medicinal chemistry letters 20110201

• Pinosylvin suppresses LPS-stimulated inducible nitric oxide synthase expression via the MyD88-independent, but TRIF-dependent downregulation of IRF-3 signaling pathway in mouse macrophage cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Nuclear factor E2-related factor 2-mediated induction of NAD(P)H:quinone oxidoreductase 1 by 3,5-dimethoxy-trans-stilbene.

  Journal of pharmacological sciences 20110101

• [Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues].

  Yao xue xue bao = Acta pharmaceutica Sinica 20101201

• In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis.

  Neuro endocrinology letters 20100101

• Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resveratrol.

  Neuro endocrinology letters 20100101

• Complexation of pinosylvin, an analogue of resveratrol with high antifungal and antimicrobial activity, by different types of cyclodextrins.

  Journal of agricultural and food chemistry 20091111

• Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol.

  Journal of medicinal chemistry 20090409

• Wounding response in xylem of Scots pine seedlings shows wide genetic variation and connection with the constitutive defence of heartwood.

  Tree physiology 20090101

• Structure-efficiency relationship in derivatives of stilbene. Comparison of resveratrol, pinosylvin and pterostilbene.

  Neuro endocrinology letters 20081001

• Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa.

  Phytotherapy research : PTR 20080701

• [Studies on chemical constituents of rhizome of Matteuccia struthiopteris].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

• Interaction of stilbene compounds with human and rainbow trout estrogen receptors.

  Environmental toxicology and chemistry 20080201

• Vibrational spectroscopy of resveratrol.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101

• Quinone reductase induction activity of methoxylated analogues of resveratrol.

  European journal of medicinal chemistry 20070601

• High-performance liquid chromatographic analysis of pterostilbene in biological fluids using fluorescence detection.

  Journal of pharmaceutical and biomedical analysis 20070104

• Pharmacokinetics of selected stilbenes: rhapontigenin, piceatannol and pinosylvin in rats.

  The Journal of pharmacy and pharmacology 20061101

• Involvement of nuclear factor-kappaB in the inhibition of pro-inflammatory mediators by pinosylvin.

  Planta medica 20060701

• Screening analyses of pinosylvin stilbenes, resin acids and lignans in Norwegian conifers.

  Molecules (Basel, Switzerland) 20060131

• Pharmacometrics of stilbenes: seguing towards the clinic.

  Current clinical pharmacology 20060101

• Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics.

  Journal of pharmaceutical and biomedical analysis 20050601

• Antibacterial and antifungal activity of pinosylvin, a constituent of pine.

  Fitoterapia 20050301

• Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.

  Journal of natural products 20050101

• Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells.

  Bioorganic & medicinal chemistry letters 20041206

• A UV resonance Raman (UVRR) spectroscopic study on the extractable compounds in Scots pine (Pinus sylvestris) wood. Part II. Hydrophilic compounds.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20041101

• New stilbene derivatives from Calligonum leucocladum.

  Journal of natural products 20040601

• Antifungal activity of stilbenes in in vitro bioassays and in transgenic Populus expressing a gene encoding pinosylvin synthase.

  Plant cell reports 20040301

• Taxonomic significance of flavonoid variation in temperate species of Nothofagus.

  Phytochemistry 20030401

• Antifungal stilbenoids from Stemona collinsae.

  Journal of natural products 20020601

• Induction of discolored wood in Scots pine (Pinus sylvestris).

  Tree physiology 20020401