223499-30-7 | Ym-58483

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$39.00	$28.00
2mg	98%	in stock	$58.00	$41.00
5mg	98%	in stock	$103.00	$72.00
10mg	98%	in stock	$134.00	$94.00
25mg	98%	in stock	$175.00	$122.00
50mg	98%	in stock	$228.00	$160.00
100mg	98%	in stock	$386.00	$271.00

Description

• Catalog Number: AF31553
• Chemical Name: Ym-58483
• CAS Number: 223499-30-7
• Molecular Formula: C15H9F6N5OS
• Molecular Weight: 421.3203
• MDL Number: MFCD00220976
• SMILES: O=C(c1snnc1C)Nc1ccc(cc1)n1nc(cc1C(F)(F)F)C(F)(F)F

Computed Properties

• Complexity: 568
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 3.8

Literature

• Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models.

  Journal of immunology (Baltimore, Md. : 1950) 20170901

• Store-operated CRAC channel inhibitors: opportunities and challenges.

  Future medicinal chemistry 20160501

• Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20140702

• Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120711

• The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta.

  Journal of vascular research 20120101

• Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.

  Stem cells (Dayton, Ohio) 20111101

• Store-operated calcium entry and non-capacitative calcium entry have distinct roles in thrombin-induced calcium signalling in human platelets.

  Cell calcium 20111001

• Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2.

  The international journal of biochemistry & cell biology 20110801

• Overexpression of transient receptor potential canonical type 1 (TRPC1) alters both store operated calcium entry and depolarization-evoked calcium signals in C2C12 cells.

  Cell calcium 20110601

• Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.

  Aging 20110601

• Gβγ subunits inhibit Epac-induced melanoma cell migration.

  BMC cancer 20110101

• Store-operated Ca(2+) entry is expressed in human endothelial progenitor cells.

  Stem cells and development 20101201

• Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells.

  Investigative ophthalmology & visual science 20100901

• Role of TRPC3 channels in ATP-induced Ca2+ signaling in principal cells of the inner medullary collecting duct.

  American journal of physiology. Renal physiology 20100701

• Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.

  Circulation research 20100625

• Knockdown of stromal interaction molecule 1 attenuates hepatocyte growth factor-induced endothelial progenitor cell proliferation.

  Experimental biology and medicine (Maywood, N.J.) 20100301

• Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo.

  International immunopharmacology 20081220

• Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides.

  Bioorganic & medicinal chemistry 20081101

• The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo.

  Pulmonary pharmacology & therapeutics 20080101

• Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils.

  Journal of leukocyte biology 20071101

• YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models.

  European journal of pharmacology 20070410

• Potent inhibition of store-operated Ca2+ influx and superoxide production in HL60 cells and polymorphonuclear neutrophils by the pyrazole derivative BTP2.

  Journal of leukocyte biology 20070401

• Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling.

  The Journal of biological chemistry 20061103

• A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia.

  Journal of neurophysiology 20061101

• Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes.

  The Journal of pharmacology and experimental therapeutics 20061001

• Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers.

  Journal of cell science 20060915

• A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.

  Molecular pharmacology 20060401

• Cell proliferation depends on mitochondrial Ca2+ uptake: inhibition by salicylate.

  The Journal of physiology 20060215

• TRPV6 potentiates calcium-dependent cell proliferation.

  Cell calcium 20060201

• [TRP channels as targets for novel calcium antagonists].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20051101

• A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.

  The Journal of biological chemistry 20050325

• Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.

  The Journal of biological chemistry 20040326

• A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20030501