22368-21-4 | Eupatilin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$11.00	$8.00
10mg	98%	in stock	$38.00	$27.00
50mg	98%	in stock	$102.00	$71.00
100mg	95%	in stock	$147.00	$103.00

Description

• Catalog Number: AF30697
• Chemical Name: Eupatilin
• CAS Number: 22368-21-4
• Molecular Formula: C18H16O7
• Molecular Weight: 344.3154
• MDL Number: MFCD13194819
• SMILES: COc1cc(ccc1OC)c1cc(=O)c2c(o1)cc(c(c2O)OC)O
• NSC Number: 122413

Computed Properties

• Complexity: 520
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 2.9

Literature

• The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20121001

• 5,7-Dihydroxy-3,4,6-trimethoxyflavone inhibits intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 via the Akt and nuclear factor-κB-dependent pathway, leading to suppression of adhesion of monocytes and eosinophils to bronchial epithelial cells.

  Immunology 20120901

• The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice.

  European journal of pharmacology 20120815

• In vivo sedative and gastroprotective activities of Salvia plebeia extract and its composition of polyphenols.

  Archives of pharmacal research 20120801

• Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells.

  Nutrition research and practice 20120401

• DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway.

  Journal of gastroenterology and hepatology 20120201

• Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• The Protective Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Ethanol-induced Damage in Cultured Feline Esophageal Epithelial Cells.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20111201

• A mechanism for the action of the compound DA-6034 on NF-κB pathway activation in Helicobacter pylori-infected gastric epithelial cells.

  Scandinavian journal of immunology 20110901

• Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801

• Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol.

  Journal of Korean medical science 20110801

• Eupatilin inhibits lipopolysaccharide-induced expression of inflammatory mediators in macrophages.

  Life sciences 20110620

• Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression.

  Journal of gastric cancer 20110301

• Dose-response study of sajabalssuk ethanol extract from Artemisia princeps Pampanini on blood glucose in subjects with impaired fasting glucose or mild type 2 diabetes.

  Journal of medicinal food 20110101

• A review on phytochemistry and medicinal properties of the genus Achillea.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells.

  Biochemical pharmacology 20101215

• Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria.

  Phytotherapy research : PTR 20101101

• Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes.

  Molecules (Basel, Switzerland) 20100916

• The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

  International journal of cell biology 20100101

• Impact of dietary polyphenols on carbohydrate metabolism.

  International journal of molecular sciences 20100101

• [Studies on flavones from Flos Chrysanthemi Indici].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091001

• Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice.

  Journal of ethnopharmacology 20090925

• Topical anti-inflammatory activity of Eupatilin, a lipophilic flavonoid from mountain wormwood ( Artemisia umbelliformis Lam.).

  Journal of agricultural and food chemistry 20090909

• Eupatilin inhibits T-cell activation by modulation of intracellular calcium flux and NF-kappaB and NF-AT activity.

  Journal of cellular biochemistry 20090901

• Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells.

  Differentiation; research in biological diversity 20090401

• Eupatilin with heme oxygenase-1-inducing ability protects cultured feline esophageal epithelial cells from cell damage caused by indomethacin.

  Biological & pharmaceutical bulletin 20090401

• 5,7-dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and I kappaB alpha and I kappaB kinase-gamma in intestinal epithelial cell culture.

  Clinical and experimental immunology 20090301

• Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response.

  PloS one 20090101

• Effects of DA-6034, a flavonoid derivative, on mucin-like glycoprotein and ocular surface integrity in a rabbit model.

  Arzneimittel-Forschung 20090101

• Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice.

  Diabetes research and clinical practice 20081001

• Eupatilin inhibits H(2)O(2)-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080801

• The protective effect of eupatilin on indomethacin-induced cell damage in cultured feline ileal smooth muscle cells: involvement of HO-1 and ERK.

  Journal of ethnopharmacology 20080619

• Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress.

  Pharmaceutical research 20080601

• DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis.

  Experimental biology and medicine (Maywood, N.J.) 20080201

• The effects of DA-6034 on NF-kappaB activity induced by lipopolysaccharide or tumor necrosis factor alpha in a human colonic epithelial cell line.

  Hepato-gastroenterology 20080101

• Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity.

  International immunopharmacology 20071215

• In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes.

  Xenobiotica; the fate of foreign compounds in biological systems 20070801

• Analysis of eupatilin-human serum albumin interactions by means of spectroscopic and computational modelling.

  The Journal of pharmacy and pharmacology 20070501

• Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species.

  Annals of the New York Academy of Sciences 20070101

• Eupatilin attenuates bile acid-induced hepatocyte apoptosis.

  Journal of gastroenterology 20060801

• Eupatilin has an antiapoptotic action on hepatocytes, in contrast to apoptotic actions on other cells.

  Journal of gastroenterology 20060801

• [Studies on the flavonoids from whole herbs of Seriphidium terrae-albae].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

• Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells.

  Journal of toxicology and environmental health. Part A 20051210

• Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20050101

• Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20050101

• Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells.

  Biochemical pharmacology 20040915

• Metabolism of eupatilin in rats using liquid chromatography/electrospray mass spectrometry.

  Biomedical chromatography : BMC 20040401

• Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.

  Biological & pharmaceutical bulletin 20020701

• Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells.

  Mutation research 20010920

• Mono- and sesquiterpenes and antifungal constituents from Artemisia species.

  Planta medica 19990201