228559-41-9 | Ki8751

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$8.00	$6.00
5mg	98+%	in stock	$12.00	$9.00
10mg	98+%	in stock	$16.00	$11.00
50mg	98+%	in stock	$51.00	$36.00

Description

• Catalog Number: AF32599
• Chemical Name: Ki8751
• CAS Number: 228559-41-9
• Molecular Formula: C24H18F3N3O4
• Molecular Weight: 469.4126
• MDL Number: MFCD09971092
• SMILES: COc1cc2nccc(c2cc1OC)Oc1ccc(c(c1)F)NC(=O)Nc1ccc(cc1F)F

Computed Properties

• Complexity: 677
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 4.5

Literature

• Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment.

  The American journal of pathology 20120301

• Hypoxylonols C-F, benzo[j]fluoranthenes from Hypoxylon truncatum.

  Journal of natural products 20120127

• Acquired drug resistance to vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor in human vascular endothelial cells.

  Anticancer research 20110901

• Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.

  Journal of medicinal chemistry 20050310