22888-70-6 | (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$14.00	$10.00
50g	≥98%	in stock	$562.00	$394.00

Description

• Catalog Number: AI45447
• Chemical Name: (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one
• CAS Number: 22888-70-6
• Molecular Formula: C25H22O10
• Molecular Weight: 482.4362
• MDL Number: MFCD00872186
• SMILES: OC[C@H]1Oc2ccc(cc2O[C@@H]1c1ccc(c(c1)OC)O)[C@H]1Oc2cc(O)cc(c2C(=O)[C@@H]1O)O
• NSC Number: 651520

Computed Properties

• Complexity: 750
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 4
• XLogP3: 2.4

Literature

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  Toxicology in vitro : an international journal published in association with BIBRA 20181001

• Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea.

  Toxicology letters 20180901

• Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin.

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• Silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating Trx/TXNIP complex, inhibiting NLRP3 inflammasome activation and apoptosis.

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• Hepatoprotective effect of 10% ethanolic extract from Curdrania tricuspidata leaves against ethanol-induced oxidative stress through suppression of CYP2E1.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001

• Evaluation of ameliorative ability of Silibinin against zidovudine and isoniazid-induced hepatotoxicity and hyperlipidaemia in rats: Role of Silibinin in Phase I and II drug metabolism.

  Chemico-biological interactions 20170801

• Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer.

  Chemico-biological interactions 20170801

• Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan.

  Toxicology and applied pharmacology 20170715

• Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity.

  Journal of biochemical and molecular toxicology 20170701

• Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170701

• The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.

  Chemico-biological interactions 20170601

• Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl(4)-induced acute liver injury and LPS-treated RAW264.7 cells.

  Toxicology letters 20170515

• Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170401

• Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170401

• Protective Effects of Ecklonia stolonifera Extract on Ethanol-Induced Fatty Liver in Rats.

  Biomolecules & therapeutics 20161101

• Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations.

  Chemico-biological interactions 20161025

• Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate LX-2 Cells.

  Journal of clinical and experimental hepatology 20160901

• Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats.

  Environmental toxicology 20160501

• Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats.

  Toxicology and applied pharmacology 20151115

• Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway.

  Chemico-biological interactions 20151005

• Effects of Melatonin-Aided Therapy on the Glutathione Antioxidant System Activity and Liver Protection.

  Journal of biochemical and molecular toxicology 20151001

• Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats.

  Toxicology letters 20150917

• Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice.

  Chemico-biological interactions 20150625

• Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice.

  Chemico-biological interactions 20150325

• Blockade of lipid accumulation by silibinin in adipocytes and zebrafish.

  Chemico-biological interactions 20150205

• Silibinin combination with arsenic strongly inhibits survival and invasiveness of human prostate carcinoma cells.

  Nutrition and cancer 20150101

• Protective role of silymarin against manganese-induced nephrotoxicity and oxidative stress in rat.

  Environmental toxicology 20141001

• Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140501

• The binding of silibinin to ERp57.

  Chemico-biological interactions 20140425

• Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation.

  Chemico-biological interactions 20140325

• Silibinin potentially attenuates arsenic-induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats.

  Cardiovascular toxicology 20140301

• Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study.

  Environmental toxicology 20140201

• Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach.

  Toxicology and applied pharmacology 20140115

• Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140101

• Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.

  Mediators of inflammation 20140101

• Silibinin as a potential therapeutic for sulfur mustard injuries.

  Chemico-biological interactions 20131205

• Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism.

  Molecular and cellular biochemistry 20131201

• Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

  Toxicological sciences : an official journal of the Society of Toxicology 20131201

• Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking.

  Cellular microbiology 20131101

• Silymarin protects from varicocele-induced damages in testis and improves sperm quality: evidence for E2f1 involvement.

  Systems biology in reproductive medicine 20131001

• Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats.

  Toxicology letters 20130523

• Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20130301

• Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats.

  Journal of agricultural and food chemistry 20130213

• Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.

  Chemico-biological interactions 20130125

• Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice.

  Cancer letters 20121229

• Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.

  Medical oncology (Northwood, London, England) 20121201

• CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation.

  Journal of cellular biochemistry 20121201

• Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells.

  Cellular signalling 20121201

• Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats.

  Molecular biology reports 20121201

• Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells.

  Free radical research 20121101

• Silibinin for cyclopeptide mushroom poisonings.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20121101

• Protection by silibinin against experimental ischemic stroke: up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression.

  Neuroscience letters 20121031

• Silibinin attenuates allergic airway inflammation in mice.

  Biochemical and biophysical research communications 20121026

• Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.

  Molecular carcinogenesis 20121001

• Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries.

  Toxicology and applied pharmacology 20121001

• In vivo evaluation of silybin nanosuspensions targeting liver.

  Journal of biomedical nanotechnology 20121001

• Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells.

  Epigenetics 20121001

• Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats.

  Life sciences 20120904

• Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.

  Phytotherapy research : PTR 20120901

• Long-term administration of Silymarin augments proinflammatory mediators in the hippocampus of rats: evidence for antioxidant and pro-oxidant effects.

  Human & experimental toxicology 20120901

• P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells.

  Free radical research 20120901

• Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Therapeutic efficacy of silibinin on human neuroblastoma cells: Akt and NF-κB expressions may play an important role in silibinin-induced response.

  Neurochemical research 20120901

• Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.

  International journal of oncology 20120901

• Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway.

  Oncology reports 20120901

• Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women.

  Journal of reproductive immunology 20120901

• Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model.

  Human & experimental toxicology 20120801

• The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.

  Apoptosis : an international journal on programmed cell death 20120801

• Novel antiosteoclastogenic activity of phloretin antagonizing RANKL-induced osteoclast differentiation of murine macrophages.

  Molecular nutrition & food research 20120801

• Hepatitis C therapy in non-genotype 1 patients: the near future.

  Journal of viral hepatitis 20120801

• High-dose silibinin rescue treatment for HCV-infected patients showing suboptimal virologic response to standard combination therapy.

  Journal of viral hepatitis 20120801

• Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models.

  Surgical endoscopy 20120701

• In vitro determination of anticryptosporidial activity of phytogenic extracts and compounds.

  Parasitology research 20120701

• Injectable and biodegradable poly(organophosphazene) gel containing silibinin: its physicochemical properties and anticancer activity.

  Journal of pharmaceutical sciences 20120701

• Silibinin inhibits tumor growth in a murine orthotopic hepatocarcinoma model and activates the TRAIL apoptotic signaling pathway.

  Anticancer research 20120701

• Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.

  Journal of medicinal chemistry 20120614

• Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones.

  Parasitology research 20120601

• Complementary and alternative medicines in prostate cancer: from bench to bedside?

  The oncologist 20120601

• Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.

  Translational research : the journal of laboratory and clinical medicine 20120601

• Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways.

  Journal of cellular biochemistry 20120501

• Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats.

  Toxicology mechanisms and methods 20120501

• Understanding silibinin's modes of action against HCV using viral kinetic modeling.

  Journal of hepatology 20120501

• Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• [Acute hepatic failure after ingestion of mushrooms].

  Der Internist 20120501

• Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells.

  Cell biochemistry and function 20120401

• Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120401

• Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide.

  Biochemical and biophysical research communications 20120316

• Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity.

  Neurochemical research 20120301

• Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner.

  Carcinogenesis 20120301

• P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.

  Free radical research 20120301

• Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin.

  The journal of pain : official journal of the American Pain Society 20120301

• Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line.

  Neurochemical research 20120201

• Metabolic effects of silibinin in the rat liver.

  Chemico-biological interactions 20120125

• Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats.

  European journal of pharmacology 20120115

• Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts.

  Journal of cellular biochemistry 20120101

• Synergistic antibacterial effect between silibinin and antibiotics in oral bacteria.

  Journal of biomedicine & biotechnology 20120101

• Silibinin is a potent sensitizer of UVA radiation-induced oxidative stress and apoptosis in human keratinocyte HaCaT cells.

  Photochemistry and photobiology 20120101

• In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles.

  International journal of nanomedicine 20120101

• In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of Sirt-1 expression and autophagy in pancreatic β-cell.

  Journal of Asian natural products research 20120101

• Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats.

  PloS one 20120101

• Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.

  PloS one 20120101

• Dual effects of silibinin treatment on autophagy-regulated dermal apoptosis retardation and epidermal apoptosis up-regulation in UVB-induced skin inflammation.

  Journal of Asian natural products research 20120101

• Metabolic acidosis during treatment of mushroom poisoning: a diagnostic pitfall.

  Internal medicine (Tokyo, Japan) 20120101

• Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation.

  PloS one 20120101

• Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.

  PloS one 20120101

• The correlation between NF-κB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis.

  Fundamental & clinical pharmacology 20111201

• Synergistic effects between silibinin and antibiotics on methicillin-resistant Staphylococcus aureus isolated from clinical specimens.

  Biotechnology journal 20111101

• Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells.

  Free radical research 20111101

• Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast cancer cells.

  Anticancer research 20111101

• Neuroprotective effect of silibinin in diabetic mice.

  Neuroscience letters 20111031

• The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats.

  Molecules (Basel, Switzerland) 20111012

• Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel.

  Molecular carcinogenesis 20111001

• Interruption of mitochondrial complex IV activity and cytochrome c expression activated O₂·⁻-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC pathways.

  European journal of pharmacology 20111001

• Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells.

  Apoptosis : an international journal on programmed cell death 20111001

• The cytotoxicity of OPA-modified CdSe/ZnS core/shell quantum dots and its modulation by silibinin in human skin cells.

  Journal of biomedical nanotechnology 20111001

• Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment.

  Behavioural brain research 20110801

• Silibinin mode of action against hepatitis C virus: a controversy yet to be resolved.

  Hepatology (Baltimore, Md.) 20110801

• Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells.

  Cancer prevention research (Philadelphia, Pa.) 20110801

• Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells.

  Free radical research 20110701

• Effect of silybin on high-fat-induced fatty liver in rats.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110701

• Identification and initial SAR of silybin: an Hsp90 inhibitor.

  Bioorganic & medicinal chemistry letters 20110501

• [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].

  Nihon rinsho. Japanese journal of clinical medicine 20110501

• Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis.

  Toxicology and applied pharmacology 20110415

• Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.

  Carcinogenesis 20110401

• Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures.

  Journal of veterinary pharmacology and therapeutics 20110401

• Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110401

• Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.

  Journal of pineal research 20110301

• Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence.

  Pharmacology, biochemistry, and behavior 20110301

• Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins.

  Journal of cellular biochemistry 20110301

• Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110215

• Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice.

  Toxicology 20110204

• Silibinin: a novel inhibitor of Aβ aggregation.

  Neurochemistry international 20110201

• Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger.

  The Journal of pharmacy and pharmacology 20110201

• Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle.

  Toxicologic pathology 20110201

• Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy.

  Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20110201

• Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.

  European journal of pharmacology 20110110

• Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin.

  Human & experimental toxicology 20110101

• Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway.

  Cancer investigation 20110101

• Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways.

  Biological & pharmaceutical bulletin 20110101

• Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria.

  Molecular cancer therapeutics 20110101

• Silibinin activated ROS-p38-NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells.

  Journal of Asian natural products research 20110101

• Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.

  PloS one 20110101

• Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death.

  Journal of experimental & clinical cancer research : CR 20110101

• Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs.

  Journal of veterinary internal medicine 20110101

• Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.

  Cardiovascular diabetology 20110101

• Natural antioxidants and vascular calcification: a possible benefit.

  Journal of nephrology 20110101

• Silibinin causes apoptosis and cell cycle arrest in some human pancreatic cancer cells.

  International journal of molecular sciences 20110101

• [Some issues of death cap (Amanita phalloides) poisoning based on cases treated in Poznan Department of Toxicology in 2010].

  Przeglad lekarski 20110101

• Intravenous silibinin as 'rescue treatment' for on-treatment non-responders to pegylated interferon/ribavirin combination therapy.

  Antiviral therapy 20110101

• [Hepatoprotectors in therapy of the alcoholic liver disease (clinical and experimental research)].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

• Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine models.

  Chemico-biological interactions 20101205

• Natural antioxidants synergistically enhance the anticancer potential of AP9-cd, a novel lignan composition from Cedrus deodara in human leukemia HL-60 cells.

  Chemico-biological interactions 20101205

• Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20101201

• Alginate-based ferrofluid and magnetic microsphere thereof.

  International journal of biological macromolecules 20101201

• Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation.

  Molecular cancer therapeutics 20101201

• Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).

  Cell cycle (Georgetown, Tex.) 20101115

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes.

  Natural product research 20101101

• Milk thistle in liver diseases: past, present, future.

  Phytotherapy research : PTR 20101001

• Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules.

  Pharmaceutical research 20101001

• Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20101001

• Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model.

  European journal of pharmacology 20100915

• Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100915

• Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors.

  Hematological oncology 20100901

• Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study.

  Toxicology and applied pharmacology 20100901

• Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer.

  Cancer metastasis reviews 20100901

• Tumor suppressor p53 status does not determine the differentiation-associated G₁ cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D₃ and antioxidants.

  Cancer biology & therapy 20100815

• Silibinin attenuates cardiac hypertrophy and fibrosis through blocking EGFR-dependent signaling.

  Journal of cellular biochemistry 20100801

• Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells.

  Nutrition and cancer 20100801

• Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with alpha-amanitin.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20100701

• Effects of silybinin, CYP3A4 and P-glycoprotein inhibitor in vitro, on the bioavailability of loratadine in rats.

  Die Pharmazie 20100701

• Protective effects of silybin and analogues against X-ray radiation-induced damage.

  Acta biochimica et biophysica Sinica 20100701

• Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis.

  Toxicon : official journal of the International Society on Toxinology 20100615

• Downregulation of nuclear factor-kappa B (NF-kappaB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis.

  Life sciences 20100605

• Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer.

  Investigational new drugs 20100601

• A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer.

  The Prostate 20100601

• Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver.

  Toxicology and applied pharmacology 20100601

• Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

• Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors.

  Oncology reports 20100601

• Multiple effects of silymarin on the hepatitis C virus lifecycle.

  Hepatology (Baltimore, Md.) 20100601

• Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles.

  Acta pharmacologica Sinica 20100601

• Preparation and in vitro evaluation of povidone-sodium cholate-phospholipid mixed micelles for the solubilization of poorly soluble drugs.

  Archives of pharmacal research 20100601

• Preparation and evaluation of galactosylated vesicular carrier for hepatic targeting of silibinin.

  Drug development and industrial pharmacy 20100501

• Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.

  Cancer letters 20100501

• Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2).

  Mutagenesis 20100501

• Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy.

  Medical hypotheses 20100501

• Establishment of a methodology for investigating protectants against ethanol-induced hepatotoxicity.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100501

• Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells.

  Free radical research 20100501

• Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling.

  Neoplasia (New York, N.Y.) 20100501

• [Protective effect of silibinin on liver injury induced by antituberculosis drugs].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100501

• [An updated review at molecular pharmacological level for the mechanism of anti-tumor, antioxidant and immunoregulatory action of silibinin].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100401

• Identification of hepatoprotective flavonolignans from silymarin.

  Proceedings of the National Academy of Sciences of the United States of America 20100330

• Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin.

  Cancer research 20100315

• Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment.

  Behavioural brain research 20100305

• Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro.

  Toxicology in vitro : an international journal published in association with BIBRA 20100301

• Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators.

  Molecular carcinogenesis 20100301

• Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.

  The Journal of pharmacology and experimental therapeutics 20100301

• Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation.

  Carcinogenesis 20100301

• Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

  Gastroenterology 20100301

• A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.

  The Journal of pharmacology and experimental therapeutics 20100301

• Silibinin--a promising new treatment for cancer.

  Anti-cancer agents in medicinal chemistry 20100301

• Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9.

  Anti-cancer drugs 20100301

• Targeting silibinin in the antiproliferative pathway.

  Expert opinion on investigational drugs 20100201

• Glycine pretreatment ameliorates liver injury after partial hepatectomy in the rat.

  Journal of investigative surgery : the official journal of the Academy of Surgical Research 20100201

• Radioprotection of plasmid and cellular DNA and Swiss mice by silibinin.

  Mutation research 20100101

• Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells.

  Free radical research 20100101

• Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats.

  Anticancer research 20100101

• Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway.

  Journal of pharmacological sciences 20100101

• Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats.

  Pharmacology 20100101

• Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats.

  Chemico-biological interactions 20091210

• Silibinin inhibits expression of HIF-1alpha through suppression of protein translation in prostate cancer cells.

  Biochemical and biophysical research communications 20091204

• Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.

  Pharmaceutical research 20091201

• Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin.

  Journal of drug targeting 20091201

• Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells.

  Journal of ethnopharmacology 20091112

• Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway.

  Molecules (Basel, Switzerland) 20091026

• Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice.

  The Journal of pharmacology and experimental therapeutics 20091001

• The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells.

  Journal of pharmacological sciences 20091001

• Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum.

  Cell biology international 20090901

• Silibinin modulates biotransforming microbial enzymes and prevents 1,2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer.

  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20090901

• Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties.

  Bioorganic & medicinal chemistry 20090901

• Free radical scavenging reactions and antioxidant activities of silybin: mechanistic aspects and pulse radiolytic studies.

  Free radical research 20090901

• Silibinin inhibits osteoclast differentiation mediated by TNF family members.

  Molecules and cells 20090901

• Silibinin inhibits glioma cell proliferation via Ca2+/ROS/MAPK-dependent mechanism in vitro and glioma tumor growth in vivo.

  Neurochemical research 20090801

• Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.

  British journal of pharmacology 20090801

• Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression.

  Acta pharmacologica Sinica 20090801

• Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft.

  Molecular cancer therapeutics 20090801

• Micronization of silybin by the emulsion solvent diffusion method.

  International journal of pharmaceutics 20090706

• Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.

  Journal of applied toxicology : JAT 20090701

• Rapid suppression of hepatitis C viremia induced by intravenous silibinin plus ribavirin.

  Gastroenterology 20090701

• Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090601

• Silibinin inhibits translation initiation: implications for anticancer therapy.

  Molecular cancer therapeutics 20090601

• The effect of silybin on passive avoidance learning and pathological changes in hippocampal CA1 and DG regions in male Wistar rats offspring.

  Journal of Asian natural products research 20090601

• Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis.

  Chemico-biological interactions 20090515

• Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.

  International journal of molecular medicine 20090501

• Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study.

  Cancer research 20090501

• Silibinin attenuates mast cell-mediated anaphylaxis-like reactions.

  Biological & pharmaceutical bulletin 20090501

• Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice.

  World journal of gastroenterology 20090428

• Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells.

  Molecular nutrition & food research 20090401

• Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.

  Journal of natural products 20090401

• Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells.

  Journal of ethnopharmacology 20090318

• AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids.

  Chemico-biological interactions 20090316

• Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090301

• Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: involvement of inducible nitric oxide synthase and hemoxygenase-1.

  Nitric oxide : biology and chemistry 20090201

• Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy.

  Oncogene 20090122

• Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090115

• Assessment of oxidative stress in leukocytes and granulocyte function following oral administration of a silibinin-phosphatidylcholine complex in cats.

  American journal of veterinary research 20090101

• Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

  Cancer prevention research (Philadelphia, Pa.) 20090101

• Failure of benzylpenicillin, N-acetylcysteine and silibinin to reduce alpha-amanitin hepatotoxicity.

  In vivo (Athens, Greece) 20090101

• Pharmacokinetic interaction between oltipraz and silymarin in rats.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101

• Optimisation of enzyme assisted extraction of silybin from the seeds of Silybum marianum by Box-Behnken experimental design.

  Phytochemical analysis : PCA 20090101

• Cosmeceuticals and silibinin.

  Clinics in dermatology 20090101

• Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin.

  International journal of cancer 20081215

• Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma.

  Cancer letters 20081208

• Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.

  Chemical & pharmaceutical bulletin 20081201

• The challenge of herbal therapies for prostate cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081201

• Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.

  Gastroenterology 20081101

• Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines.

  Phytotherapy research : PTR 20081101

• Treatment with silybin-vitamin E-phospholipid complex in patients with hepatitis C infection.

  Journal of medical virology 20081101

• Fast repair activities towards dGMP hydroxyl radical adducts by silybin and its analogues.

  Journal of radiation research 20081101

• [Amanita poisoning--comparison of silibinin with a combination of silibinin and penicillin].

  Deutsche medizinische Wochenschrift (1946) 20081001

• Interspecies comparison of the glucuronidation processes in the man, monkey, pig, dog and rat.

  Neuro endocrinology letters 20081001

• Cell growth inhibition and down-regulation of survivin by silibinin in a laryngeal squamous cell carcinoma cell line.

  The Annals of otology, rhinology, and laryngology 20081001

• Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.

  Cancer prevention research (Philadelphia, Pa.) 20081001

• Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation.

  European journal of pharmacology 20080904

• Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells.

  Pharmaceutical research 20080901

• Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.

  Cancer research 20080815

• Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line.

  Cell biology international 20080801

• Synergistic antibacterial effect between silybin and N,N'-dicyclohexylcarbodiimide in clinical Pseudomonas aeruginosa isolates.

  Journal of microbiology (Seoul, Korea) 20080801

• The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: a comparison with desferrioxamine.

  European journal of pharmacology 20080728

• Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.

  Cancer chemotherapy and pharmacology 20080701

• Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.

  International journal of cancer 20080701

• Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

• Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.

  Biological & pharmaceutical bulletin 20080701

• Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells.

  Journal of pharmacological sciences 20080701

• Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells.

  Molecular cancer therapeutics 20080701

• Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes.

  Life sciences 20080523

• Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin.

  Biochimica et biophysica acta 20080501

• Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.

  European journal of cancer (Oxford, England : 1990) 20080401

• Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.

  Cancer research 20080315

• Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats.

  Drug metabolism and disposition: the biological fate of chemicals 20080301

• Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury.

  Journal of ethnopharmacology 20080212

• Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: a joint experimental and theoretical study.

  The journal of physical chemistry. A 20080207

• Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201

• In vitro evaluation and pharmacokinetics in dogs of solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating.

  Planta medica 20080201

• Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats.

  Phytotherapy research : PTR 20080101

• Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080101

• Preparation and properties of a silybin-phospholipid complex.

  Die Pharmazie 20080101

• Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice.

  The American journal of Chinese medicine 20080101

• Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells.

  Anticancer research 20080101

• Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.

  Carcinogenesis 20071201

• Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice.

  Molecular cancer therapeutics 20071201

• Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats.

  Acta biologica Hungarica 20071201

• Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application.

  Journal of pharmaceutical and biomedical analysis 20071130

• Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.

  Cancer research 20071115

• Silybin is metabolized by cytochrome P450 2C8 in vitro.

  Drug metabolism and disposition: the biological fate of chemicals 20071101

• Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.

  The Journal of surgical research 20071101

• Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.

  The Journal of pharmacy and pharmacology 20071101

• Effects and mechanisms of silibinin on human hepatoma cell lines.

  World journal of gastroenterology 20071028

• Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice.

  Environmental toxicology 20071001

• p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.

  Molecular cancer therapeutics 20071001

• Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.

  Archives of pharmacal research 20071001

• Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20070901

• Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.

  Annals of emergency medicine 20070901

• Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms.

  Acta pharmacologica Sinica 20070901

• Effects of silibinin hemisuccinate on the intraocular pressure in normotensive rabbits.

  Saudi medical journal 20070901

• Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin.

  Cancer research 20070901

• Renal and hepatic injury with elevated cardiac enzymes in Amanita phalloides poisoning: a case report.

  Human & experimental toxicology 20070901

• Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride.

  Molecular and cellular biochemistry 20070801

• Therapeutic value of orally administered silibinin in renal cell carcinoma: manipulation of insulin-like growth factor binding protein-3 levels.

  BJU international 20070801

• Protective effects of Cuscutae semen against dimethylnitrosamine-induced acute liver injury in Sprague-Dawley rats.

  Biological & pharmaceutical bulletin 20070801

• Preparation and characterization of solid lipid nanoparticles containing silibinin.

  Drug delivery 20070801

• Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells.

  Carcinogenesis 20070701

• Iron chelation or anti-oxidants prevent renal cell damage in the rewarming phase after normoxic, but not hypoxic cold incubation.

  Cryobiology 20070601

• Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent.

  Acta pharmacologica Sinica 20070601

• Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy.

  Integrative cancer therapies 20070601

• Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2.

  Carcinogenesis 20070501

• Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070501

• Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells.

  International journal of cancer 20070501

• Simultaneous determination of lithospermic acid B and its three metabolites by liquid chromatography/tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20070411

• Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites.

  Journal of agricultural and food chemistry 20070404

• Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.

  Toxicological sciences : an official journal of the Society of Toxicology 20070401

• A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients.

  Investigational new drugs 20070401

• Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice.

  Cancer research 20070401

• [Amatoxin poisoning due to soup from personally picked deathcap mushrooms (Amanita phalloides)].

  Nederlands tijdschrift voor geneeskunde 20070331

• Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells.

  Biochemical and biophysical research communications 20070302

• [Protective effect of silibinin against isoproterenol-induced injury to cardiac myocytes and its mechanism].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070301

• Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

  Carcinogenesis 20070201

• Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells.

  Journal of cellular physiology 20070201

• Influence of silybin on biophysical properties of phospholipid bilayers.

  Acta pharmacologica Sinica 20070201

• Silibinin inhibits renal cell carcinoma via mechanisms that are independent of insulin-like growth factor-binding protein 3.

  BJU international 20070201

• Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis.

  Journal of gastroenterology and hepatology 20070101

• Formulation and biopharmaceutical evaluation of silymarin using SMEDDS.

  Archives of pharmacal research 20070101

• (+)-Silybin, a pharmacologically active constituent of Silybum marianum: fragmentation studies by atmospheric pressure chemical ionization quadrupole time-of-flight tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perfused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.

  Burns : journal of the International Society for Burn Injuries 20061201

• Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1.

  Journal of pharmacological sciences 20061201

• Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.

  Carcinogenesis 20061101

• Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.

  The Indian journal of medical research 20061101

• Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A.

  Biochemistry. Biokhimiia 20061001

• [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats].

  Zhonghua yi xue za zhi 20060926

• Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle.

  Biological & pharmaceutical bulletin 20060901

• Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice.

  Molecular cancer therapeutics 20060801

• Synthesis and antioxidant evaluation of novel silybin analogues.

  Journal of enzyme inhibition and medicinal chemistry 20060801

• Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.

  Cancer letters 20060708

• Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice.

  Molecular cancer therapeutics 20060701

• Effect of silibinin on the growth and progression of primary lung tumors in mice.

  Journal of the National Cancer Institute 20060621

• Prostate cancer chemoprevention by silibinin: bench to bedside.

  Molecular carcinogenesis 20060601

• Antiparasitic activity of flavonoids and isoflavones against Cryptosporidium parvum and Encephalitozoon intestinalis.

  FEMS microbiology letters 20060601

• Cadmium-induced apoptosis in murine macrophages is antagonized by antioxidants and caspase inhibitors.

  Journal of toxicology and environmental health. Part A 20060601

• Silibinin prevents UV-induced HaCaT cell apoptosis partly through inhibition of caspase-8 pathway.

  Biological & pharmaceutical bulletin 20060601

• Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.

  Journal of chromatography. A 20060526

• Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.

  Journal of biomedical science 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060501

• Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells.

  Molecular cancer therapeutics 20060501

• Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization.

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060501

• MDR- and CYP3A4-mediated drug-herbal interactions.

  Life sciences 20060327

• Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway.

  Journal of dental research 20060301

• Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.

  Cell biology and toxicology 20060301

• Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.

  Oncogene 20060216

• The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats.

  International journal of pharmaceutics 20060103

• In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1;1)-DMA-kaempferide.

  Acta tropica 20060101

• Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20060101

• [Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].

  Recenti progressi in medicina 20060101

• Silibinin efficacy against human hepatocellular carcinoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20051201

• Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.

  Neoplasia (New York, N.Y.) 20051201

• Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells.

  Archives of pharmacal research 20051201

• Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation.

  Toxicology 20051105

• Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20051101

• Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways.

  Chemico-biological interactions 20051020

• Protective effects of silybin on human umbilical vein endothelial cell injury induced by H2O2 in vitro.

  Vascular pharmacology 20051001

• [Progress in research of aldose reductase inhibitors in traditional medicinal herbs].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001

• Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation.

  The Journal of surgical research 20050901

• Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.

  European journal of cancer (Oxford, England : 1990) 20050901

• Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

  The FEBS journal 20050901

• A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).

  Alternative medicine review : a journal of clinical therapeutic 20050901

• Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.

  Life sciences 20050826

• Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin.

  Carcinogenesis 20050801

• Iron and iron chelating agents modulate Mycobacterium tuberculosis growth and monocyte-macrophage viability and effector functions.

  FEMS immunology and medical microbiology 20050801

• Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050701

• [Preparation of silybin-phospholipid complex and its bioavailability in rats].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050701

• Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide.

  Life sciences 20050624

• Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate B in beagle dog serum.

  Journal of pharmaceutical and biomedical analysis 20050601

• [Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study].

  Minerva gastroenterologica e dietologica 20050601

• Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.

  The Journal of biological chemistry 20050527

• Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.

  Basic & clinical pharmacology & toxicology 20050501

• Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050501

• Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP.

  Biochemical pharmacology 20050401

• Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis.

  World journal of gastroenterology 20050227

• Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy.

  Oncogene 20050210

• Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation.

  Molecular cancer therapeutics 20050201

• Potential utility of natural polyphenols for reversing fat-induced insulin resistance.

  Medical hypotheses 20050101

• Metal-induced oxidative damage in cultured hepatocytes and hepatic lysosomal fraction: beneficial effect of a curcumin/absinthium compound.

  Chinese journal of digestive diseases 20050101

• Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats.

  Journal of biomedical science 20050101

• Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes.

  Journal of biochemical and molecular toxicology 20050101

• Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041215

• A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer.

  Mutation research 20041102

• Oxidised derivatives of silybin and their antiradical and antioxidant activity.

  Bioorganic & medicinal chemistry 20041101

• Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.

  Carcinogenesis 20040901

• Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.

  Cancer research 20040901

• Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.

  Carcinogenesis 20040801

• Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.

  Molecular carcinogenesis 20040701

• Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows.

  Journal of dairy science 20040701

• Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity.

  Pharmacological research 20040501

• Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells.

  The Journal of urology 20040501

• Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells.

  Planta medica 20040501

• Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling.

  Toxicology and applied pharmacology 20040401

• Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells.

  Oncology reports 20040201

• Prostate cancer prevention by silibinin.

  Current cancer drug targets 20040201

• Effect of silybin on phorbol myristate actetate-induced protein kinase C translocation, NADPH oxidase activity and apoptosis in human neutrophils.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20040201

• Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes.

  Carcinogenesis 20040101

• Involvement of NF-kappaB and caspases in silibinin-induced apoptosis of endothelial cells.

  International journal of molecular medicine 20040101

• Silymarin extraction from milk thistle using hot water.

  Applied biochemistry and biotechnology 20040101

• Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.

  Biochemical and biophysical research communications 20031226

• Comparative bioavailability of silibinin in healthy male volunteers.

  International journal of clinical pharmacology and therapeutics 20031201

• Effects of flavonoids on the resistance of microsomes to lipid peroxidation in vitro and ex vivo.

  Bulletin of experimental biology and medicine 20031201

• Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.

  Oncogene 20031113

• [Amanita poisoning during pregnancy].

  Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20031101

• Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.

  Toxicology 20030930

• Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death.

  International journal of cancer 20030920

• Application of liquid chromatography-electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905

• Silibinin protects mice from T cell-dependent liver injury.

  Journal of hepatology 20030901

• Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030901

• Cytotoxicity of inorganic mercury in murine T and B lymphoma cell lines: involvement of reactive oxygen species, Ca(2+) homeostasis, and cytokine gene expression.

  Toxicology in vitro : an international journal published in association with BIBRA 20030801

• Gram-positive bacteria specific properties of silybin derived from Silybum marianum.

  Archives of pharmacal research 20030801

• Anti-angiogenic effect of silymarin on colon cancer LoVo cell line.

  The Journal of surgical research 20030701

• Plasma lipoproteins in transport of silibinin, an antioxidant flavonolignan from Silybum marianum.

  Phytotherapy research : PTR 20030501

• Mechanism-based in vitro screening of potential cancer chemopreventive agents.

  Mutation research 20030101

• Extraction of nutraceuticals from milk thistle: I. Hot water extraction.

  Applied biochemistry and biotechnology 20030101

• [St. Mary's Thistle: an overview].

  Journal de pharmacie de Belgique 20030101

• Preparation and pharmacological evaluation of silibinin liposomes.

  Arzneimittel-Forschung 20030101

• Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells.

  Anticancer research 20030101

• Primary human hepatocytes are protected against prolonged and repeated exposure to ethanol by silibinin-dihemisuccinate.

  Alcohol and alcoholism (Oxford, Oxfordshire) 20030101

• Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line.

  Cancer biology & therapy 20030101

• Silibinin: a thorny therapeutic for EGF-R expressing tumors?

  Cancer biology & therapy 20030101

• Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells.

  The Prostate 20021101

• Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

  Phytotherapy research : PTR 20021101

• Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20021101

• Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent.

  Diabetes, nutrition & metabolism 20020801

• Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention.

  Molecular cancer therapeutics 20020501

• Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin.

  BMC complementary and alternative medicine 20020101

• The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.

  Cell cycle (Georgetown, Tex.) 20020101

• Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships.

  Journal of medicinal chemistry 20010118

• Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin.

  Carcinogenesis 20000401

• Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.

  The Journal of pharmacology and experimental therapeutics 19990901

• Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats.

  Hepatology (Baltimore, Md.) 19970901

• Inhibition of reverse transcriptases by flavonoids.

  Antiviral research 19890901

• [Effectiveness of legalon and essentiale in a tetracycline-induced liver lesion].

  Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology 19861001