2415-24-9 | Catalpol

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
10mg	98%	in stock	$25.00	$17.00
50mg	98%	in stock	$53.00	$37.00
100mg	98%	in stock	$75.00	$52.00
250mg	98%	in stock	$149.00	$104.00
1g	98%	in stock	$409.00	$286.00

Description

• Catalog Number: AB52233
• Chemical Name: Catalpol
• CAS Number: 2415-24-9
• Molecular Formula: C15H22O10
• Molecular Weight: 362.3292
• MDL Number: MFCD11111524
• SMILES: OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@@H]3[C@H]2[C@@]2(CO)O[C@H]2[C@H]3O)[C@@H]([C@H]([C@@H]1O)O)O

Computed Properties

• Complexity: 542
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 11
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 4
• XLogP3: -3.2

Literature

• Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by D-galactose.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130801

• Catalpol inhibits LPS plus IFN-γ-induced inflammatory response in astrocytes primary cultures.

  Toxicology in vitro : an international journal published in association with BIBRA 20130301

• Anti-hyperglycemic effects and mechanism of traditional Chinese medicine Huanglian Wan in streptozocin-induced diabetic rats.

  Journal of ethnopharmacology 20121121

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• HPLC-APCI-MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: application to an in vivo pharmacokinetic study.

  Journal of pharmaceutical and biomedical analysis 20121101

• In vitro and in vivo metabolism of verproside in rats.

  Molecules (Basel, Switzerland) 20121012

• A rapid and sensitive determination of aucubin in rat plasma by liquid chromatography-tandem mass spectrometry and its pharmacokinetic application.

  Biomedical chromatography : BMC 20120901

• [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• [Study on the HPCE fingerprint of Rehmannia glutinosa].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120401

• Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms.

  Brain research 20120302

• Effect of high relative humidity on dried Plantago lanceolata L. leaves during long-term storage: effects on chemical composition, colour and microbiological quality.

  Phytochemical analysis : PCA 20120101

• In vitro cytotoxic activity and structure activity relationships of iridoid glucosides derived from Veronica species.

  Phytotherapy research : PTR 20120101

• Traditional chinese medicine for senile dementia.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Diet quality can play a critical role in defense efficacy against parasitoids and pathogens in the Glanville fritillary (Melitaea cinxia).

  Journal of chemical ecology 20120101

• Anthelmintic and relaxant activities of Verbascum Thapsus Mullein.

  BMC complementary and alternative medicine 20120101

• Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Host shifts from Lamiales to Brassicaceae in the sawfly genus Athalia.

  PloS one 20120101

• Ginkgo biloba extract EGB761 protects against aging-associated diastolic dysfunction in cardiomyocytes of D-galactose-induced aging rat.

  Oxidative medicine and cellular longevity 20120101

• Iridoid content and biological activities of Veronica cuneifolia subsp. cuneifolia and V. cymbalaria.

  Pharmaceutical biology 20111101

• In silico study of the inhibition of DNA polymerase by a novel catalpol derivative.

  Journal of molecular modeling 20111001

• Chemical defense across three trophic levels: Catalpa bignonioides, the caterpillar Ceratomia catalpae, and its endoparasitoid Cotesia congregata.

  Journal of chemical ecology 20111001

• Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam.

  Journal of ethnopharmacology 20110714

• Differential performance of a specialist and two generalist herbivores and their parasitoids on Plantago lanceolata.

  Journal of chemical ecology 20110701

• [Effects of Chinese herbal medicine Liuwei Dihuang Pill and its main monomer catalpol on transforming growth factor-β1/Smad pathway in HK-2 cells].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110701

• Iridoid and phenylethanoid glucosides from Veronica lavaudiana.

  Journal of natural products 20110624

• Protective effects of catalpol on oligodendrocyte death and myelin breakdown in a rat model of chronic cerebral hypoperfusion.

  Neuroscience letters 20110615

• A comparison of sample preparation techniques for quantifying iridoid glycosides sequestered by lepidopteran larvae.

  Journal of chemical ecology 20110501

• Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats.

  Journal of agricultural and food chemistry 20110427

• What's in a Name? Can Mullein Weed Beat TB Where Modern Drugs Are Failing?

  Evidence-based complementary and alternative medicine : eCAM 20110101

• A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

  International journal of molecular sciences 20110101

• Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map.

  PloS one 20110101

• Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots.

  Chemical & pharmaceutical bulletin 20110101

• Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica.

  Biological & pharmaceutical bulletin 20110101

• Plant community diversity influences allocation to direct chemical defence in Plantago lanceolata.

  PloS one 20110101

• Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons.

  ISRN neurology 20110101

• [Bio-activity evaluation of Qinlian Siwu decoction on inhibiting mice uterine contraction in vitro and its components analysis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

• [End point determination by HPLC chromatographic fingerprint in processing prepared Rehmannia].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

• Chlorinated iridoid glucosides from Veronica longifolia and their antioxidant activity.

  Journal of natural products 20100924

• Analysis of catalpol derivatives by characteristic neutral losses using liquid chromatography combined with electrospray ionization multistage and time-of-flight mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20100915

• Caterpillar chemical defense and parasitoid success: Cotesia congregata parasitism of Ceratomia catalpae.

  Journal of chemical ecology 20100901

• Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats.

  Journal of natural products 20100625

• [Studies on the chemical constituents of Buddleja albiflora (II)].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

• Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum.

  Neuroscience 20100428

• Systemic administration of catalpol prevents D-galactose induced mitochondrial dysfunction in mice.

  Neuroscience letters 20100412

• Enhancement of antiproliferative activity by molecular simplification of catalpol.

  Bioorganic & medicinal chemistry 20100401

• Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-α and Nitric Oxide Production In Vitro.

  Evidence-based complementary and alternative medicine : eCAM 20100301

• Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax.

  European journal of pharmacology 20100225

• Sequestration of glucosinolates and iridoid glucosides in sawfly species of the genus Athalia and their role in defense against ants.

  Journal of chemical ecology 20100201

• Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats.

  Brain research 20100111

• Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion.

  International journal of biological sciences 20100101

• Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam.

  Frontiers in neuroscience 20100101

• Cholinesterase inhibitory and antioxidant properties of Verbascum mucronatum Lam. and its secondary metabolites.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101

• Screening of common Plantago species in Hungary for bioactive molecules and antioxidant activity.

  Acta biologica Hungarica 20100101

• [The 14 plants in Issenheim's altarpiece. An updated pharmaco-chemical approach].

  Histoire des sciences medicales 20100101

• Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway.

  Neurochemistry international 20091201

• [Investigation of oxidative stress-induced alterations in the rat brain cortical cellular culture and their correction with vitamines E and C].

  Georgian medical news 20091201

• [Progress in studies of pharmacological action and mechanisms of catalpol on brain diease].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

• Catalpol ameliorates beta amyloid-induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors.

  Neuroscience 20091110

• Quantitation of catalpol in rat plasma by liquid chromatography/electrospray ionization tandem mass spectrometry and its pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101

• Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20090908

• Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20090901

• Liquid chromatography-mass spectrometry for the simultaneous determination of the catalpol-related iridoid glucosides, verproside, isovanilloylcatalpol, catalposide and 6-O-veratroyl catalpol in rat plasma.

  Biomedical chromatography : BMC 20090901

• [Theoretical study on infrared vibration spectrum of catalpol by DFT].

  Guang pu xue yu guang pu fen xi = Guang pu 20090901

• Elucidation of anti-inflammatory potencies of Eucommia ulmoides bark and Plantago asiatica seeds.

  Journal of medicinal food 20090801

• [Protective effects of catalpol against H2O2-induced oxidative damage in astrocytes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

• Arbuscular mycorrhizal fungal species suppress inducible plant responses and alter defensive strategies following herbivory.

  Oecologia 20090701

• The effects of arbuscular mycorrhizal fungi on direct and indirect defense metabolites of Plantago lanceolata L.

  Journal of chemical ecology 20090701

• [HPLC determination of catalpol in cerebrospinal fluid of rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

• Chemical defense, mycorrhizal colonization and growth responses in Plantago lanceolata L.

  Oecologia 20090601

• Iridoids from Spathodea campanulata P. Beauvais leaves.

  Natural product communications 20090601

• Pharmacokinetics of verproside after intravenous and oral administration in rats.

  Archives of pharmacal research 20090401

• Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons.

  Neurochemistry international 20090101

• Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp.

  Journal of natural products 20090101

• Iridoids from Euphrasia genargentea, a rare Sardinian endemism.

  Natural product research 20090101

• Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• Catapol production in Chinese foxglove (Rehmannia glutinosa Libos.) hairy roots transformed with Agrobacterium rhizogenes ATCC15834.

  Methods in molecular biology (Clifton, N.J.) 20090101

• Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes.

  Frontiers in neuroenergetics 20090101

• Decontamination of organochlorine pesticides residue and heavy metal in Rehmannia glutinosa Libosch by SFE.

  Journal of chromatographic science 20090101

• Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity.

  Toxicology in vitro : an international journal published in association with BIBRA 20081201

• Intraspecific variation in plant defense alters effects of root herbivores on leaf chemistry and aboveground herbivore damage.

  Journal of chemical ecology 20081001

• Protective effects of catalpol against H2O2-induced oxidative stress in astrocytes primary cultures.

  Neuroscience letters 20080919

• Oviposition cues for a specialist butterfly--plant chemistry and size.

  Journal of chemical ecology 20080901

• [Comparative analysis of character on germplasm resources of Rehmannia glutinosa].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• d-galactose administration induces memory loss and energy metabolism disturbance in mice: protective effects of catalpol.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080801

• Phytochemistry and molecular systematics of Triaenophora rupestris and Oreosolen wattii (Scrophulariaceae).

  Phytochemistry 20080801

• Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity.

  Neurological research 20080701

• Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080601

• Catalpol protects rat pheochromocytoma cells against oxygen and glucose deprivation-induced injury.

  Neurological research 20080201

• Catalpol attenuates the neurotoxicity induced by beta-amyloid(1-42) in cortical neuron-glia cultures.

  Brain research 20080110

• Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080101

• Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose.

  Pharmacology, biochemistry, and behavior 20071101

• [Study of catalpol promoting axonal growth for cultured cortical neurons from rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

• [Hairy root induction and plant regeneration of Rehmannia glutinosa Libosch. f. hueichingensis (Chao et Schih) Hsiao transformed by Agrobacterium rhizogenes].

  Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20070801

• Neuroprotective effect of catalpol against MPP(+)-induced oxidative stress in mesencephalic neurons.

  European journal of pharmacology 20070730

• Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20070601

• [Advances in research on pharmacodynamics and chemical conversion of catalpol].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

• [Effect of concentration of catalpol and 5-hydroxymethyl-2-furaldehyde from processing of Rehmanniae Radix].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

• Phenylethanoids, iridoids and a spirostanol saponin from Veronica turrilliana.

  Phytochemistry 20070501

• Efficacy of catalpol as protectant against oxidative stress and mitochondrial dysfunction on rotenone-induced toxicity in mice brain.

  Environmental toxicology and pharmacology 20070501

• Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham.

  Journal of ethnopharmacology 20070404

• Occurrence of iridoid glycosides in in vitro cultures and intact plants of Scrophularia nodosa L.

  Plant cell reports 20070301

• Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol.

  Bioorganic & medicinal chemistry letters 20070301

• Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures.

  Life sciences 20061223

• Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats.

  Brain research 20061206

• Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury.

  Brain research 20061018

• Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides.

  Phytotherapy research : PTR 20060701

• Taxonomical markers in two endemic plants of Sardinia: Verbascum conocarpum and Scrophularia trifoliata.

  Natural product research 20060510

• Chemotaxonomy of Veroniceae and its allies in the Plantaginaceae.

  Phytochemistry 20060201

• Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury.

  Toxicon : official journal of the International Society on Toxinology 20051215

• Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots.

  Phytochemistry 20050201

• Neuroprotective properties of catalpol in transient global cerebral ischemia in gerbils: dose-response, therapeutic time-window and long-term efficacy.

  Brain research 20041217

• Neuroprotection of catalpol in transient global ischemia in gerbils.

  Neuroscience research 20041001

• Patterns of iridoid glycoside production and induction in Plantago lanceolata and the importance of plant age.

  Journal of chemical ecology 20040901

• Inhibition of Taq DNA polymerase by catalpol.

  Cellular and molecular biology (Noisy-le-Grand, France) 20040901

• Plant chemical defense against herbivores and pathogens: generalized defense or trade-offs?

  Oecologia 20040801

• Aliphatic alcohol and iridoid glycosides from Asystasia intrusa.

  Chemical & pharmaceutical bulletin 20040801

• Iridoid glucosides of Paederota lutea and the relationships between Paederota and Veronica.

  Phytochemistry 20040701

• Earthworms and litter distribution affect plant-defensive chemistry.

  Journal of chemical ecology 20040401

• Iridoids as allelochemicals and DNA polymerase inhibitors.

  Journal of natural products 20040301

• [Determination of catalpol in dried rehmannia root and Taohong Siwu Decoction with high performance liquid chromatography].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20040301

• Determination of aucubin and catalpol in Plantago species by micellar electrokinetic chromatography.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

• Catalpol inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade.

  Toxicon : official journal of the International Society on Toxinology 20040101

• Hostplant suitability and defensive chemistry of the Catalpa sphinx, Ceratomia catalpae.

  Journal of chemical ecology 20031001

• Aragoside and iridoid glucosides from Aragoa cundinamarcensis.

  Phytochemistry 20030901

• Determination of iridoid glycosides in larvae and adults of butterfly Melitaea cinxia by partial filling micellar electrokinetic capillary chromatography-electrospray ionisation mass spectrometry.

  Analytical and bioanalytical chemistry 20030701

• Colorimetric estimation of total iridoid content of Picrorhiza kurrooa.

  Journal of Asian natural products research 20030601

• Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade.

  Journal of the American Chemical Society 20030430

• Effect of iridoid glycoside content on oviposition host plant choice and parasitism in a specialist herbivore.

  Journal of chemical ecology 20030401

• [Study on chitosan clarification refining the decoction of jiangtangtongmai by homogenous design method].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030201

• On-line identification of unstable catalpol derivatives from Jamesbrittenia fodina by LC-mS and LC-NMR.

  Phytochemical analysis : PCA 20030101

• Iridoids from Globularia dumulosa.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

• Iridoid glucosides from Veronica pectinata var. glandulosa.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

• Systemic, genotype-specific induction of two herbivore-deterrent iridoid glycosides in Plantago lanceolata L. in response to fungal infection by Diaporthe adunca (Rob.) Niessel.

  Journal of chemical ecology 20021201

• Changes in the concentrations of bioactive compounds in plantain leaves.

  Journal of agricultural and food chemistry 20020424

• Iridoid patterns of genus Plantago L. and their systematic significance.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• [Comparison and correlative analysis on characters of Rehmannia glutinosa Libosch. Varieties].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20011201

• Determination of iridoid glycosides by micellar electrokinetic capillary chromatography-mass spectrometry with use of the partial filling technique.

  Electrophoresis 20010801

• Iridoid glycosides from Globularia trichosantha.

  Journal of natural products 20010101

• Iridoids from Stachys grandidentata (Labiatae).

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101