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Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.
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Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data.
Antimicrobial agents and chemotherapy 20121101
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Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate.
Molecular pharmacology 20120801
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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nature communications 20120101
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A general framework for inhibitor resistance in protein kinases.
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Pharmacologic correction of dominant-negative GH1 deficiency causing mutations.
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Kinase inhibitors modulate huntingtin cell localization and toxicity.
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Simultaneous visualization of both signaling cascade activity and end-point gene expression in single cells.
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PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.
Molecular pain 20110101
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Extracellular 3',5'-cAMP-adenosine pathway inhibits glomerular mesangial cell growth.
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A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Epilepsia 20100301
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Adenosine A1 receptor blockage mediates theophylline-associated seizures.
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Deciphering ligand dependent degree of binding site closure and its implication in inhibitor design: A modeling study on human adenosine kinase.
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Predominance of adenosine excitatory over inhibitory effects on transmission at the neuromuscular junction of infant rats.
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Expression and functional activity of nucleoside transporters in human choroid plexus.
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Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
Cell biology and toxicology 20090601
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Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells.
Clinical and experimental immunology 20090601
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Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
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A CoMSIA study on the adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues.
Bioorganic & medicinal chemistry 20080501
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Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells.
Biochemical pharmacology 20080401
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Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity.
Bioorganic & medicinal chemistry 20080401
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alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments.
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Adenosine uptake-dependent C6 cell growth inhibition.
European journal of pharmacology 20071222
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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
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Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.
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Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy.
Molecular cancer 20070101
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Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cyclic GMP independent.
The European journal of neuroscience 20061101
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AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma.
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Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution.
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AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model.
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Differential effect of insulin and elevated glucose level on adenosine handling in rat T lymphocytes.
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Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues.
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Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
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Cardioprotection following adenosine kinase inhibition in rat hearts.
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Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions.
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Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism.
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A TOPS-MODE approach to predict adenosine kinase inhibition.
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Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.
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Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
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Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2.
Biochemistry 20030318
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Pseudomonas aeruginosa internalization by corneal epithelial cells involves MEK and ERK signal transduction proteins.
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Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase.
Biochemical pharmacology 20020601
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QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach.
Bioorganic & medicinal chemistry letters 20020325
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Enhancement of cellular adenosine triphosphate levels in PC12 cells by extracellular adenosine.
Biological & pharmaceutical bulletin 20020301
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Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors.
British journal of pharmacology 20011101
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Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum.
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Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents.
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