245116-90-9 | Lidorestat

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$282.00	$197.00

Description

• Catalog Number: AB24717
• Chemical Name: Lidorestat
• CAS Number: 245116-90-9
• Molecular Formula: C18H11F3N2O2S
• Molecular Weight: 376.3523
• MDL Number: MFCD08067733
• SMILES: OC(=O)Cn1cc(c2c1cccc2)Cc1sc2c(n1)c(F)c(cc2F)F

Computed Properties

• Complexity: 543
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 4.4

Literature

• Identification of new non-carboxylic acid containing inhibitors of aldose reductase.

  Bioorganic & medicinal chemistry 20100601

• Diabetic cataract-pathogenesis, epidemiology and treatment.

  Journal of ophthalmology 20100101

• Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

  Bioorganic & medicinal chemistry letters 20090401

• Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat.

  The Journal of pharmacology and experimental therapeutics 20090201

• Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.

  Bioorganic & medicinal chemistry 20080601

• Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

  Journal of medicinal chemistry 20050505

• Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options.

  Endocrine reviews 20050501