24697-74-3 | Leonurine

Packsize	Purity	Availability	Price	Discounted Price
10mg	≥98%	in stock	$63.00	$45.00
1g	97%	in stock	$74.00	$52.00
5g	97%	in stock	$211.00	$148.00
10g	97%	in stock	$387.00	$271.00
25g	97%	in stock	$822.00	$575.00

Description

• Catalog Number: AB25572
• Chemical Name: Leonurine
• CAS Number: 24697-74-3
• Molecular Formula: C14H21N3O5
• Molecular Weight: 311.3336
• MDL Number: MFCD09839432
• SMILES: COc1cc(cc(c1O)OC)C(=O)OCCCCNC=NN

Computed Properties

• Complexity: 360
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 9
• XLogP3: 0.5

Literature

• Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke.

  Brain research 20120920

• Leonurine: a new comer in the natural compounds affecting atherosclerosis.

  Atherosclerosis 20120901

• SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways.

  Atherosclerosis 20120901

• Leonurine protects against tumor necrosis factor-α-mediated inflammation in human umbilical vein endothelial cells.

  Atherosclerosis 20120501

• Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways.

  European journal of pharmacology 20120405

• Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-κB pathway in db/db mice.

  Bioscience reports 20120401

• Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats.

  Biomedical chromatography : BMC 20120401

• Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro.

  International journal of molecular sciences 20120101

• Effects of Leonurine on L-type calcium channel in rat ventricular myocytes.

  Biological & pharmaceutical bulletin 20120101

• Effects of leonurine hydrochloride on medically induced incomplete abortion in early pregnancy rats.

  European journal of obstetrics, gynecology, and reproductive biology 20111201

• Leonurine-cysteine analog conjugates as a new class of multifunctional anti-myocardial ischemia agent.

  European journal of medicinal chemistry 20110901

• Neuroprotective effects of SCM198 on 6-hydroxydopamine-induced behavioral deficit in rats and cytotoxicity in neuronal SH-SY5Y cells.

  Neurochemistry international 20110701

• H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S?

  PloS one 20110101

• Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction.

  European journal of pharmacology 20101215

• Antiapoptotic effect of novel compound from Herba leonuri - leonurine (SCM-198): a mechanism through inhibition of mitochondria dysfunction in H9c2 cells.

  Current pharmaceutical biotechnology 20101201

• Synthesis and biological evaluation of novel leonurine-SPRC conjugate as cardioprotective agents.

  Bioorganic & medicinal chemistry letters 20101201

• Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function.

  Stroke 20101101

• Development and validation of an UPLC-DAD-MS method for the determination of leonurine in Chinese motherwort (Leonurus japonicus).

  Journal of chromatographic science 20101101

• Leonurine improves ischemia-induced myocardial injury through antioxidative activity.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100801

• Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex.

  Biological & pharmaceutical bulletin 20100101

• Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling.

  Frontiers in pharmacology 20100101

• 4-Guanidino-n-butyl syringate (Leonurine, SCM 198) protects H9c2 rat ventricular cells from hypoxia-induced apoptosis.

  Journal of cardiovascular pharmacology 20091101

• Protective effects of leonurine in neonatal rat hypoxic cardiomyocytes and rat infarcted heart.

  Clinical and experimental pharmacology & physiology 20090701

• Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells.

  European journal of pharmacology 20090610

• [Determination of leonurine in leonurus granule and extractum by UPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601

• Effect of leonurine on the activity of creatine kinase.

  Journal of Asian natural products research 20041201

• [Determination of stachydrine and leonurine in Herba Leonuri by ion- pair reversed-phase high-performance liquid chromatography].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20041101

• Enhancement of phenylephrine-induced contraction in the isolated rat aorta with endothelium by H2O-extract from an Oriental medicinal plant Leonuri herba.

  Japanese journal of pharmacology 20010601

• Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort.

  Life sciences 20010112