252917-06-9 | Chir-99021

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$11.00	$8.00
10mg	98%	in stock	$36.00	$25.00
100mg	98%	in stock	$169.00	$119.00

Description

• Catalog Number: AB50326
• Chemical Name: Chir-99021
• CAS Number: 252917-06-9
• Molecular Formula: C22H18Cl2N8
• Molecular Weight: 465.3379
• MDL Number: MFCD11846251
• SMILES: N#Cc1ccc(nc1)NCCNc1ncc(c(n1)c1ccc(cc1Cl)Cl)c1[nH]cc(n1)C

Computed Properties

• Complexity: 645
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 7
• XLogP3: 4.3

Literature

• Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.

  Toxicological sciences : an official journal of the Society of Toxicology 20180901

• Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio).

  Toxicology and applied pharmacology 20180115

• Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells.

  Archives of toxicology 20170101

• Crosstalk between AhR and wnt/β-catenin signal pathways in the cardiac developmental toxicity of PM2.5 in zebrafish embryos.

  Toxicology 20160429

• Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

  Toxicological sciences : an official journal of the Society of Toxicology 20151101

• Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

  The Journal of biological chemistry 20150529

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Roles of glycogen synthase kinase 3 in Alzheimer's disease.

  Current Alzheimer research 20120901

• Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway.

  Stem cells and development 20120901

• Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.

  Molecular & cellular proteomics : MCP 20120801

• Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.

  Nature biotechnology 20120701

• Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523

• Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms.

  Carcinogenesis 20120301

• Simple and efficient derivation of mouse embryonic stem cell lines using differentiation inhibitors or proliferation stimulators.

  Stem cells and development 20120210

• Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics.

  Bioorganic & medicinal chemistry 20120201

• Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia.

  Biochemical and biophysical research communications 20120113

• Establishment of ES cells from inbred strain mice by dual inhibition (2i).

  The Journal of reproduction and development 20120101

• Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains.

  PloS one 20120101

• New insights into the mechanisms of embryonic stem cell self-renewal under hypoxia: a multifactorial analysis approach.

  PloS one 20120101

• Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells.

  Angewandte Chemie (International ed. in English) 20111118

• Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy.

  American journal of physiology. Cell physiology 20111101

• In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes.

  Cell research 20110901

• Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing.

  Cell death and differentiation 20110301

• Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100707

• Identification and regulation of glycogen synthase kinase-3 during bovine embryo development.

  Reproduction (Cambridge, England) 20100701

• Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability.

  Genesis (New York, N.Y. : 2000) 20100501

• Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.

  Stem cells (Dayton, Ohio) 20091201

• The ground state of embryonic stem cell self-renewal.

  Nature 20080522

• 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication.

  Journal of medicinal chemistry 20080410

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.

  IDrugs : the investigational drugs journal 20060101

• Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.

  BMC molecular biology 20040101

• Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.

  Diabetes 20030301

• Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

  Diabetes 20000201

• Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

  Diabetes 19990801

• Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

  Proceedings of the National Academy of Sciences of the United States of America 19930815