253-82-7 | Quinazoline

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$15.00	$10.00
1g	98%	in stock	$24.00	$17.00
5g	98%	in stock	$56.00	$39.00
25g	98%	in stock	$162.00	$114.00

Description

• Catalog Number: AB78769
• Chemical Name: Quinazoline
• CAS Number: 253-82-7
• Molecular Formula: C8H6N2
• Molecular Weight: 130.1466
• MDL Number: MFCD00006712
• SMILES: c1ccc2c(c1)ncnc2
• NSC Number: 72372

Computed Properties

• Complexity: 114
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 1

Literature

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  Molecular cancer 20110101

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  Arzneimittel-Forschung 20110101

• Molecular-field-based three-dimensional similarity studies on quinoline-based CNS active agents.

  ISRN pharmaceutics 20110101

• Investigational approaches for mesothelioma.

  Frontiers in oncology 20110101

• Evaluation of modified PEG-anilinoquinazoline derivatives as potential agents for EGFR imaging in cancer by small animal PET.

  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20101201

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  European journal of medicinal chemistry 20101201

• Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells.

  Investigative ophthalmology & visual science 20101101

• Management of ErbB2-positive breast cancer: insights from preclinical and clinical studies with lapatinib.

  Japanese journal of clinical oncology 20101101

• Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.

  European journal of medicinal chemistry 20101101

• New octahydroquinazoline derivatives: synthesis and hypotensive activity.

  European journal of medicinal chemistry 20101101

• Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.

  Biochemistry 20101005

• Diphenyl(1-naphthyl)phosphine ancillary for assembling of red and orange-emitting Ir(III) based phosphors; strategic synthesis, photophysics, and organic light-emitting diode fabrication.

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  Archiv der Pharmazie 20101001

• Refractory aggressive keratoacanthoma centrifugum marginatum of the scalp controlled with the epidermal growth factor receptor inhibitor erlotinib.

  The British journal of dermatology 20100901

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  European journal of medicinal chemistry 20100901

• New substituted 4-arylaminoquinazolines as potent inhibitors of breast tumor cell lines: in vitro and docking experiments.

  European journal of medicinal chemistry 20100901

• Design, synthesis, and evaluation of quinazoline T cell proliferation inhibitors.

  Bioorganic & medicinal chemistry 20100901

• ONSH: optimization of oxidative alkylamination reactions through study of the reaction mechanism.

  The Journal of organic chemistry 20100806

• Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains.

  International journal of antimicrobial agents 20100801

• Synthesis, characterization and biological evaluation of In(III) complexes anchored by DOTA-like chelators bearing a quinazoline moiety.

  Metallomics : integrated biometal science 20100801

• Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.

  Bioorganic & medicinal chemistry letters 20100715

• Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.

  Endocrinology 20100701

• 3-[(2-Chloro-6-methyl-quinolin-3-yl)meth-yl]quinazolin-4(3H)-one.

  Acta crystallographica. Section E, Structure reports online 20100701

• (E)-3-[4-(Dimethyl-amino)-benzyl-idene]-2,3-di-hydro-1H,9H-pyrrolo-[2,1-b]quinazolin-9-one.

  Acta crystallographica. Section E, Structure reports online 20100701

• N-[3-Chloro-4-(3-fluoro-benz-yloxy)phen-yl]-6-iodo-quinazolin-4-amine.

  Acta crystallographica. Section E, Structure reports online 20100701

• Receptor-based virtual screening of EGFR kinase inhibitors from the NCI diversity database.

  Molecules (Basel, Switzerland) 20100604

• 7,9-Dichloro-6H,12H-indolo[2,1-b]quinazoline-6,12-dione.

  Acta crystallographica. Section E, Structure reports online 20100601

• Enantioseparation and plant virucidal bioactivity of new quinazoline derivatives with alpha-aminophosphonate moiety.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100515

• Photoinduced tandem reactions of isoquinoline-1,3,4-trione with alkynes to build aza-polycycles.

  The Journal of organic chemistry 20100507

• (E)-3-Propoxymethyl-idene-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one monohydrate.

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• Synthesis and antimycobacterial activity of azetidine-, quinazoline-, and triazolo-thiadiazole-containing pyrazines.

  Archiv der Pharmazie 20100401

• Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer.

  Journal of enzyme inhibition and medicinal chemistry 20100401

• Subcellular distribution of a fluorescence-labeled combi-molecule designed to block epidermal growth factor receptor tyrosine kinase and damage DNA with a green fluorescent species.

  Molecular cancer therapeutics 20100401

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  Biochemistry 20100302

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• Silodosin in the treatment of benign prostatic hyperplasia.

  Drug design, development and therapy 20100101

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  International journal of molecular sciences 20100101

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  International journal of molecular sciences 20100101

• Reactive oxygen species enhance TLR10 expression in the human monocytic cell line THP-1.

  International journal of molecular sciences 20100101

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  Scientia pharmaceutica 20100101

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• Cancer chemotherapy: targeting folic acid synthesis.

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  Bioorganic & medicinal chemistry 20091001

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  Bioorganic & medicinal chemistry 20080401

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  British journal of cancer 20080311

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  The open medicinal chemistry journal 20080101

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  Bioorganic & medicinal chemistry 20071115

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  Molecular and biochemical parasitology 20071101

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  The Journal of urology 20071101

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  Bioorganic & medicinal chemistry 20070615

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  Talanta 20070615

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  Metal-based drugs 20070101

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  Life sciences 20060710

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  Molecular pharmacology 20060701

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  Cancer biology & therapy 20060701

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  Molecular cancer therapeutics 20060701

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  Organic & biomolecular chemistry 20060621

• The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR).

  Journal of medicinal chemistry 20060615

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  Biochimica et biophysica acta 20060501

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  Bioorganic & medicinal chemistry letters 20060301

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  European journal of medicinal chemistry 20060301

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  Brain research 20060105

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  Cell biochemistry and function 20060101

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  Mini reviews in medicinal chemistry 20060101

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  Arzneimittel-Forschung 20060101

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  Organic & biomolecular chemistry 20051221

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  Annals of oncology : official journal of the European Society for Medical Oncology 20051201

• Cytotoxicity and detection of damage to DNA by 3-(5-nitro-2-thienyl)-9-chloro-5-morpholin-4-yl[1,2,4]triazolo[4,3-c] quinazoline on human cancer cell line HeLa.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201

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  Molecules (Basel, Switzerland) 20050930

• Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

  Journal of molecular biology 20050909

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  Bioorganic & medicinal chemistry 20050801

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  Clinical cancer research : an official journal of the American Association for Cancer Research 20050801

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

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  PLoS medicine 20050301

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  Journal of medicinal chemistry 20050210

• alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101

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  Phytochemical analysis : PCA 20050101

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  Molecular pharmaceutics 20050101

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  Lipids in health and disease 20050101

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  Journal of computer-aided molecular design 20050101

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  The Journal of pharmacology and experimental therapeutics 20041201

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  Chemical & pharmaceutical bulletin 20041201

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  Farmaco (Societa chimica italiana : 1989) 20041201

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  Biochemical pharmacology 20041001

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  Clinical cancer research : an official journal of the American Association for Cancer Research 20041001

• Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man.

  Xenobiotica; the fate of foreign compounds in biological systems 20041001

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  Archiv der Pharmazie 20020101

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• Total solid phase syntheses of the quinazoline alkaloids: verrucines A and B and anacine.

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  Mini reviews in medicinal chemistry 20011101

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