254-79-5 | 1,5-Naphthyridine

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$8.00	$6.00
1g	95%	in stock	$9.00	$7.00
5g	98%	in stock	$29.00	$20.00
10g	98%	in stock	$52.00	$36.00
25g	98%	in stock	$114.00	$80.00
100g	98%	in stock	$418.00	$292.00

Description

• Catalog Number: AB43201
• Chemical Name: 1,5-Naphthyridine
• CAS Number: 254-79-5
• Molecular Formula: C8H6N2
• Molecular Weight: 130.1466
• MDL Number: MFCD00039727
• SMILES: c1cnc2c(c1)nccc2
• NSC Number: 87514

Computed Properties

• Complexity: 99.8
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 1.3

Literature

• 1,8-Naphthyridine-2,7-diamine: a potential universal reader of Watson-Crick base pairs for DNA sequencing by electron tunneling.

  Organic & biomolecular chemistry 20121121

• Exploring the role of water molecules for docking and receptor guided 3D-QSAR analysis of naphthyridine derivatives as spleen tyrosine kinase (Syk) inhibitors.

  Journal of chemical information and modeling 20121022

• 4-Diphenyl-phosphanyl-1,5-naphthyridine.

  Acta crystallographica. Section E, Structure reports online 20121001

• Novel multifunctional organic semiconductor materials based on 4,8-substituted 1,5-naphthyridine: synthesis, single crystal structures, opto-electrical properties and quantum chemistry calculation.

  Organic & biomolecular chemistry 20120907

• New domino heteroannulation of enaminones: synthesis of diverse fused naphthyridines.

  Organic & biomolecular chemistry 20120728

• A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis.

  Anti-cancer agents in medicinal chemistry 20120701

• Synthesis of 1,8-naphthyridines and their application in the development of anionic fluorogenic chemosensors.

  Journal of fluorescence 20120701

• Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes.

  Organic & biomolecular chemistry 20120528

• In silico and in vitro genotoxicity evaluation of levofloxacin n-oxide, an impurity in levofloxacin.

  Toxicology mechanisms and methods 20120401

• Methyl 1-ethyl-7-methyl-4-oxo-1,4-di-hydro-1,8-naphthyridine-3-carboxyl-ate monohydrate.

  Acta crystallographica. Section E, Structure reports online 20120301

• Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives.

  Organic & biomolecular chemistry 20120107

• Bis(morpholin-4-ium) tetra-chlorido-cobalt(II).

  Acta crystallographica. Section E, Structure reports online 20120101

• Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies.

  Frontiers in microbiology 20120101

• Radiosensitization by the novel DNA intercalating agent vosaroxin.

  Radiation oncology (London, England) 20120101

• A fluorescence study of new angular polycyclic blue light-emitting pyrazolo[3,4-h][1,6]naphthyridine and their interaction with bovine serum albumin (BSA).

  Journal of fluorescence 20111101

• (rac)-1,1'-binaphthyl-based simple receptors designed for fluorometric discrimination of maleic and fumaric acids.

  The journal of physical chemistry. B 20110707

• Aqua-[2-(2-pyrid-yl)-1,8-naphthyridine-κN,N](2,2':6',2''-terpyridine-κN,N',N'')ruthenium(II) bis-(hexa-fluorido-phosphate) acetone sesquisolvate.

  Acta crystallographica. Section E, Structure reports online 20110601

• Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20110515

• Triptycene-derived oxacalixarenes as new wheels for the synthesis of [2]rotaxanes: acid-base- and metal-ion-switchable complexation processes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110502

• Molecular recognition of the antiretroviral drug abacavir: towards the development of a novel carbazole-based fluorosensor.

  Journal of fluorescence 20110501

• 2,6-Diamino-pyridinium tetra-phenyl-borate-1,2-bis-(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene (1/1).

  Acta crystallographica. Section E, Structure reports online 20110501

• 7-(4-Meth-oxy-phen-yl)-4,9-dimethyl-N-(4-methyl-phen-yl)-5,12-diaza-tetra-phen-6-amine.

  Acta crystallographica. Section E, Structure reports online 20110401

• Sensitive and selective fluorescence detection of guanosine nucleotides by nanoparticles conjugated with a naphthyridine receptor.

  Analytical and bioanalytical chemistry 20110101

• 2,9-Dimethyl-7-phenyl-N-(4-methyl-phen-yl)dibenzo[b,h][1,6]naphthyridin-6-amine.

  Acta crystallographica. Section E, Structure reports online 20110101

• Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.

  PloS one 20110101

• In the quest of drugs for bad bugs: are newer fluoroquinolones any better?

  Journal of laboratory physicians 20110101

• Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.

  Acta naturae 20110101

• Bimetallic catalysis involving dipalladium(I) and diruthenium(I) complexes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20101227

• Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.

  Chemical research in toxicology 20101115

• Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality.

  Bioorganic & medicinal chemistry letters 20101115

• Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.

  Cancer chemotherapy and pharmacology 20101001

• Regioselective facile one-pot Friedländer synthesis of sugar-based heterocyclic biomolecules.

  Carbohydrate research 20100923

• Identification of orally available naphthyridine protein kinase D inhibitors.

  Journal of medicinal chemistry 20100812

• QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors.

  European journal of medicinal chemistry 20100701

• 1,3-Diphenyl-3,4-dihydro-benzo[b][1,6]naphthyridine.

  Acta crystallographica. Section E, Structure reports online 20100501

• Molecular recognition studies on naphthyridine derivatives.

  Molecules (Basel, Switzerland) 20100303

• Mapping the transformation [{Ru(II)(CO)(3)Cl(2)}(2)]-->[Ru(I) (2)(CO)(4)](2+): implications in binuclear water-gas shift chemistry.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100222

• Theoretical study of the peripheral disulfide bridge substituent effects on the antioxidant properties of naphthyridine diol derivatives.

  The journal of physical chemistry. A 20100121

• trans-Pyridyl and naphthyridyl cinnamides as alternatives for urea in complexation of carboxylic acid and formation of water-templated assemblies in the solid state.

  The journal of physical chemistry. B 20100114

• Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

  PloS one 20100101

• Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor.

  Molecular vision 20100101

• Extended use of raltegravir in the treatment of HIV-1 infection: optimizing therapy.

  Infection and drug resistance 20100101

• Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses.

  Aging cell 20091201

• N'-[(E)-Benzyl-idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.

  Acta crystallographica. Section E, Structure reports online 20091201

• Face-to-face porphyrin moieties assembled with spacing for pyrazine recognition in molecularly imprinted polymers.

  Biosensors & bioelectronics 20091115

• Synergism between pyronaridine and retinol in Plasmodium falciparum in vitro.

  Wiener klinische Wochenschrift 20091001

• Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification.

  Journal of medicinal chemistry 20090924

• Synthesis and in-vitro antitumour activity of new naphthyridine derivatives on human pancreatic cancer cells.

  The Journal of pharmacy and pharmacology 20090801

• 1,5-Naphthyridine as a new linker for the construction of bridging ligands and their corresponding Ru(II) complexes.

  Inorganic chemistry 20090720

• Nitroimidazole-based bioreductive compounds bearing a quinazoline or a naphthyridine chromophore.

  Anti-cancer drugs 20090701

• 2,2',4,4'-Tetra-methyl-7,7'-diazenediylbis(1,8-naphthyridin-1-ium) bis-(perchlorate).

  Acta crystallographica. Section E, Structure reports online 20090701

• μ-Bis(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene]bis-[difluoridoboron(III).

  Acta crystallographica. Section E, Structure reports online 20090701

• Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models.

  Cancer chemotherapy and pharmacology 20090601

• 3,6-Dimethyl-1-phenyl-4-(2-thien-yl)-8-(2-thienylmethyl-ene)-5,6,7,8-tetra-hydro-1H-pyrazolo[3,4-b][1,6]naphthyridine.

  Acta crystallographica. Section E, Structure reports online 20090501

• N-[6-(Dibromo-meth-yl)-2-pyrid-yl]-2,2-dimethyl-propionamide.

  Acta crystallographica. Section E, Structure reports online 20090401

• 1-Ethyl-N'-[(E)-4-hydroxy-benzyl-idene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.

  Acta crystallographica. Section E, Structure reports online 20090401

• 7-(2,2-Dimethylpropanamido)-2-methyl-1,8-naphthyridin-1-ium chloride monohydrate.

  Acta crystallographica. Section E, Structure reports online 20090201

• Selective targeting of tumorigenic cancer cell lines by microtubule inhibitors.

  PloS one 20090101

• Synthesis, characterization, antibacterial and anti-inflammatory activities of enoxacin metal complexes.

  Bioinorganic chemistry and applications 20090101

• 3,5-Dichloro-6-methyl-pyridin-2-amine.

  Acta crystallographica. Section E, Structure reports online 20090101

• Interactions of 1,5-naphthyridine with Pd(en)Cl2 or [Pd(en)(H2O)2](NO3)2 in aqueous solution.

  Dalton transactions (Cambridge, England : 2003) 20081207

• Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.

  Bioorganic & medicinal chemistry letters 20081001

• Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains.

  Diagnostic microbiology and infectious disease 20080901

• Hexa-μ(2)-acetato-1:2κO:O';1:2κO:O;2:3κO:O';2:3κO:O-bis-(2-amino-7-chloro-5-methyl-1,8-naphthyridine)-1κN,3κN-trizinc(II).

  Acta crystallographica. Section E, Structure reports online 20080901

• 2,2'-Dimethyl-7,7'-(methyl-enediimino)di-1,8-naphthyridin-1-ium bis-(perchlorate).

  Acta crystallographica. Section E, Structure reports online 20080901

• Extended metal-atom chains with an inert second row transition metal: [Ru5(mu5-tpda)4X2] (tpda2- = tripyridyldiamido dianion, X = Cl and NCS).

  Journal of the American Chemical Society 20080806

• Toward prediction of alkane/water partition coefficients.

  Journal of medicinal chemistry 20080710

• Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.

  Bioorganic & medicinal chemistry letters 20080601

• SNS-595, a naphthyridine cell cycle inhibitor and stimulator of apoptosis for the treatment of cancers.

  Current opinion in investigational drugs (London, England : 2000) 20080601

• Raltegravir: first in class HIV integrase inhibitor.

  Therapeutics and clinical risk management 20080401

• cis,trans-Dicarbonyl-dichlorido[2-(2-pyrid-yl)-1,8-naphthyridine-κN,N]ruthenium(II).

  Acta crystallographica. Section E, Structure reports online 20080301

• Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative.

  Organic & biomolecular chemistry 20080121

• Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.

  PloS one 20080101

• Raltegravir in the management of HIV-infected patients.

  Drug design, development and therapy 20080101

• Dichloridobis(7-amino-2,4-dimethyl-1,8-naphthyridine-κN,N')cobalt(II) methanol disolvate.

  Acta crystallographica. Section E, Structure reports online 20080101

• Bis(7-amino-2,4-dimethyl-1,8-naphthyridine)dinitratocadmium(II).

  Acta crystallographica. Section E, Structure reports online 20080101

• 7-[4-(5,7-Dimethyl-1,8-naphthyridin-2-yl-oxy)phen-oxy]-2,4-dimethyl-1,8-naphthyridine methanol disolvate.

  Acta crystallographica. Section E, Structure reports online 20080101

• Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20071201

• [Study of derivatives of 2, 6-diaminopyridine as fluorescence probe of transition metal ions].

  Guang pu xue yu guang pu fen xi = Guang pu 20071201

• Synthesis and evaluation of naphthyridine compounds as antimalarial agents.

  Bioorganic & medicinal chemistry letters 20071115

• Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions.

  Archiv der Pharmazie 20071101

• Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey.

  Chemical research in toxicology 20071101

• Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.

  Anti-cancer agents in medicinal chemistry 20071101

• Tetrahydro-1,8-naphthyridinol analogues of alpha-tocopherol as antioxidants in lipid membranes and low-density lipoproteins.

  Journal of the American Chemical Society 20070822

• Analysis of mismatched DNA by mismatch binding ligand (MBL)-Sepharose affinity chromatography.

  Analytical and bioanalytical chemistry 20070701

• Tosufloxacin tosilate-induced thrombocytopenic purpura.

  The Journal of dermatology 20070701

• Analysis of the gastric H,K ATPase for ion pathways and inhibitor binding sites.

  Biochemistry 20070508

• Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.

  Bioorganic & medicinal chemistry letters 20070501

• 2-Amino-5,7-dimethyl-1,8-naphthyridine as a fluorescent reagent for the determination of nitrite.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070301

• In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate.

  Retrovirology 20070101

• Multi-class confirmatory method for analyzing trace levels of tetracyline and quinolone antibiotics in pig tissues by ultra-performance liquid chromatography coupled with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Electrochemical and fluorescence detection of cytosine-related SNPs using a ferrocenyl naphthyridine derivative.

  Nucleic acids symposium series (2004) 20070101

• Fluorescence-based affinity labeling of nucleobase by hydrogen-bond forming metal complex.

  Nucleic acids symposium series (2004) 20070101

• Strong binding of naphthyridine derivatives to cytosine in an AP site-containing DNA duplex and their application to fluorescence detection of single nucleotide polymorphisms.

  Nucleic acids symposium series (2004) 20070101

• First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B.

  Archiv der Pharmazie 20061201

• Ratiometric fluorescence detection of pyrimidine/purine transversion by using a 2-amino-1,8-naphthyridine derivative.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060201

• Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study.

  Journal of inflammation (London, England) 20060101

• A quadruply hydrogen bonded heterocomplex displaying high-fidelity recognition.

  Journal of the American Chemical Society 20051228

• Luminescence ranging from red to blue: a series of copper(I)-halide complexes having rhombic {Cu2(mu-X)2} (X = Br and I) units with N-heteroaromatic ligands.

  Inorganic chemistry 20051226

• Hydrogen bond directed synthesis of pyridazine and naphthyridine containing macrocycles.

  Chemical communications (Cambridge, England) 20051214

• Two-stage sensing property via a conjugated donor-acceptor-donor constitution: application to the visual detection of mercuric ion.

  The Journal of organic chemistry 20050722

• A highly stable quadruply hydrogen-bonded heterocomplex useful for supramolecular polymer blends.

  Journal of the American Chemical Society 20050511

• The effect of reduction on rhenium(I) complexes with binaphthyridine and biquinoline ligands: a spectroscopic and computational study.

  The journal of physical chemistry. A 20050428

• NMR structural analysis of the G.G mismatch DNA complexed with naphthyridine-dimer.

  Nucleic acids symposium series (2004) 20050101

• Strong binding of naphthyridine derivatives to a guanine base in DNA duplexes containing an AP site.

  Nucleic acids symposium series (2004) 20050101

• Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors.

  Journal of medicinal chemistry 20040826

• Formation of branched calixarene aggregates-a time-resolved static light scattering study.

  Journal of the American Chemical Society 20040804

• The binding of guanine-guanine mismatched DNA to naphthyridine dimer immobilized sensor surfaces: kinetic aspects.

  Bioorganic & medicinal chemistry 20040615

• Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors.

  Bioorganic & medicinal chemistry 20040415

• Enoxacin trihydrate.

  Acta crystallographica. Section C, Crystal structure communications 20040401

• Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.

  Journal of medicinal chemistry 20040325

• Highly sensitive detection of GG mismatched DNA by surfaces immobilized naphthyridine dimer through poly(ethylene oxide) linkers.

  Bioorganic & medicinal chemistry letters 20040308

• Affinity labeling of a single guanine bulge.

  Journal of the American Chemical Society 20030730

• Spectroscopic and theoretical studies of derivatives of 1,6- and 1,7-naphthyridines.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030501

• Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.

  Journal of medicinal chemistry 20030327

• Formation and destruction of the guanine quartet in solution observed by cold-spray ionization mass spectrometry.

  Chemical communications (Cambridge, England) 20030321

• Induction of a remarkable conformational change in a human telomeric sequence by the binding of naphthyridine dimer: inhibition of the elongation of a telomeric repeat by telomerase.

  Journal of the American Chemical Society 20030122

• The binding of naphthyridine tetramer to guanine-rich sequences.

  Nucleic acids research. Supplement (2001) 20030101

• Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1.

  Journal of medicinal chemistry 20021205

• Chemically induced hairpin formation in DNA monolayers.

  Journal of the American Chemical Society 20020619

• Binding analysis between naphthyridine dimers and GG mismatch DNA.

  Nucleic acids research. Supplement (2001) 20020101

• Recognition of guanine-guanine mismatches by the dimeric form of 2-amino-1,8-naphthyridine.

  Journal of the American Chemical Society 20011219

• Improved selectivity for the binding of naphthyridine dimer to guanine-guanine mismatch.

  Bioorganic & medicinal chemistry 20010901

• 5-amino-4-(4-diethylaminophenyl)-2-(4-hydroxyphenyl)-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile.

  Acta crystallographica. Section C, Crystal structure communications 20010601

• Selective amination of secoiridoid glycosides to give monomeric pyridine, dimeric pyridine, and naphthyridine alkaloids.

  Natural product letters 20010101