25433-13-0 | 1-Methyl-5-phenyl-1h-imidazole-2-thiol

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$217.00	$152.00
1g	95%	in stock	$479.00	$335.00

Description

• Catalog Number: AD19731
• Chemical Name: 1-Methyl-5-phenyl-1h-imidazole-2-thiol
• CAS Number: 25433-13-0
• Molecular Formula: C10H10N2S
• Molecular Weight: 190.2648
• MDL Number: MFCD01429053
• SMILES: Cn1c(S)ncc1c1ccccc1

Computed Properties

• Complexity: 241
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 1.6

Literature

• Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.

  Molecules (Basel, Switzerland) 20121022

• Phenylmethimazole inhibits production of proinflammatory mediators and is protective in an experimental model of endotoxic shock*.

  Critical care medicine 20120301

• Another potential therapeutic agent for the management of critically ill patients with sepsis syndrome: same old story, same old result?*.

  Critical care medicine 20120301

• Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages.

  The Journal of endocrinology 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis.

  European journal of pharmacology 20100915

• Regulation of major histocompatibility complex gene expression in thyroid epithelial cells by methimazole and phenylmethimazole.

  The Journal of endocrinology 20100101

• Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090615

• Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.

  Molecular endocrinology (Baltimore, Md.) 20050501

• Phenyl methimazole inhibits TNF-alpha-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20040801