26095-59-0 | Otilonium bromide

Packsize	Purity	Availability	Price	Discounted Price
10mg	98%	in stock	$6.00	$4.00
50mg	98%	in stock	$7.00	$5.00
1g	98%	in stock	$26.00	$18.00
5g	98%	in stock	$32.00	$22.00
25g	98%	in stock	$92.00	$65.00
100g	98%	in stock	$356.00	$249.00

Description

• Catalog Number: AB28937
• Chemical Name: Otilonium bromide
• CAS Number: 26095-59-0
• Molecular Formula: C29H43BrN2O4
• Molecular Weight: 563.5667
• MDL Number: MFCD00211142
• SMILES: CCCCCCCCOc1ccccc1C(=O)Nc1ccc(cc1)C(=O)OCC[N+](CC)(CC)C.[Br-]

Computed Properties

• Complexity: 600
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 17

Literature

• The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide.

  European review for medical and pharmacological sciences 20120101

• Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome.

  Alimentary pharmacology & therapeutics 20110801

• Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110101

• Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015

• Effect of otilonium bromide on contractile patterns in the human sigmoid colon.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100601

• T-type Ca(2+) channel modulation by otilonium bromide.

  American journal of physiology. Gastrointestinal and liver physiology 20100501

• Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier.

  Journal of pharmaceutical sciences 20080901

• Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats.

  Archives of pharmacal research 20080101

• Irritable bowel syndrome.

  Clinical drug investigation 20070101

• Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20040401

• Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20040401

• [New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis].

  Klinicheskaia meditsina 20040101

• Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome.

  Current pharmaceutical design 20040101

• The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts.

  British journal of pharmacology 20021201

• Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome.

  European journal of gastroenterology & hepatology 20021201

• Oesophageal motility disorders.

  Lancet (London, England) 20020112

• Multicenter phase III clinical trial of otilonium bromide in irritable bowel syndrome.

  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20020101

• Optimisation and validation of a capillary electrophoresis method for the simultaneous determination of diazepam and otilonium bromide.

  The Analyst 20011001

• [Functional intestinal disorders and quality of life].

  Gastroenterologie clinique et biologique 20010901

• Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome.

  Journal of physiology, Paris 20010101

• Effects exerted by otilonium bromide administration on precipitated opioid withdrawal syndrome in rats.

  Toxicology 19970926