27013-91-8 | Alpha-hederin

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$8.00	$6.00
5mg	98%	in stock	$14.00	$10.00
10mg	98%	in stock	$20.00	$14.00
100mg	98%	in stock	$93.00	$65.00
250mg	98%	in stock	$185.00	$130.00
1g	98%	in stock	$469.00	$328.00

Description

• Catalog Number: AF29972
• Chemical Name: Alpha-hederin
• CAS Number: 27013-91-8
• Molecular Formula: C41H66O12
• Molecular Weight: 750.9555
• MDL Number: MFCD26960932
• SMILES: OC[C@]1(C)[C@H](CC[C@]2(C1CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@@H]2CC(CC1)(C)C)C(=O)O)C)C)O[C@@H]1OC[C@@H]([C@@H]([C@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O

Computed Properties

• Complexity: 1440
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 18
• Heavy Atom Count: 53
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 7
• Rotatable Bond Count: 6
• XLogP3: 3.6

Literature

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• Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation?

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• Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus.

  Journal of natural products 20110923

• Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle.

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  Molecules (Basel, Switzerland) 20101103

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  Planta medica 20101101

• Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS.

  Talanta 20100615

• Resistance in the plant, Barbarea vulgaris, and counter-adaptations in flea beetles mediated by saponins.

  Journal of chemical ecology 20100301

• Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.

  Biochemistry 20090421

• Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.

  Bioorganic & medicinal chemistry 20090301

• Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa.

  Phytochemistry 20090301

• Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells.

  Phytotherapy research : PTR 20081001

• A convenient preparation of a disaccharide motif and its role in the cytotoxicity of the triterpenoid saponin, alpha-hederin.

  Archives of pharmacal research 20080501

• Synthesis of beta-hederin and Hederacolchiside A1: triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety.

  Carbohydrate research 20060116

• Involvement of cytokines in the hepatic metallothionein expression by alpha-hederin.

  Planta medica 20050801

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  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050701

• Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20050601

• Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines.

  Anticancer research 20050101

• Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells.

  Anticancer research 20050101

• Antioxidant activity of saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F.

  Planta medica 20040601

• Dynamics of beta2-adrenergic receptor-ligand complexes on living cells.

  Biochemistry 20040525

• Antifungal steroid saponins from Dioscorea cayenensis.

  Planta medica 20040101

• Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract.

  Biological & pharmaceutical bulletin 20030401

• Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells.

  Molecular and cellular biochemistry 20030301

• An unusual case of death: suffocation caused by leaves of common ivy (Hedera helix). Detection of hederacoside C, alpha-hederin, and hederagenin by LC-EI/MS-MS.

  Journal of analytical toxicology 20030101

• Expression of inducible nitric oxide synthase by alpha-hederin in macrophages.

  Planta medica 20020501

• Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals.

  Journal of ethnopharmacology 20020201

• Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent.

  Journal of ethnopharmacology 20020101

• New bisdesmosidic triterpene saponins from the roots of Pulsatilla chinensis.

  Journal of natural products 20010901

• In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B.

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• Toxicology of Kalopanax pictus extract and hematological effect of the isolated anti-rheumatoidal kalopanaxsaponin A on the Freunds complete adjuvant reagent-treated rat.

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• Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides.

  Planta medica 20010301

• Extraction, isolation and characterisation of antitumor principle, alpha-hederin, from the seeds of Nigella sativa.

  Planta medica 20010201

• A new dammarane-type triterpene glycoside from Polyscias fulva.

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  Annales de biologie clinique 20010101

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  Die Pharmazie 20000401

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  Cancer letters 19990426

• Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice.

  Biochemistry and molecular biology international 19981201

• Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi.

  Archives of pharmacal research 19981201

• Triterpenes as potential dimerization inhibitors of HIV-1 protease.

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