27200-12-0 | Dihydromyricetin

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$8.00	$5.00
10mg	98%	in stock	$9.00	$6.00
50mg	98%	in stock	$12.00	$8.00
1g	98%	in stock	$18.00	$12.00
5g	98%	in stock	$46.00	$32.00
10g	98%	in stock	$86.00	$60.00
100g	98%	in stock	$588.00	$411.00

Description

• Catalog Number: AB45560
• Chemical Name: Dihydromyricetin
• CAS Number: 27200-12-0
• Molecular Formula: C15H12O8
• Molecular Weight: 320.251
• MDL Number: MFCD00189451
• SMILES: Oc1cc2O[C@H](c3cc(O)c(c(c3)O)O)[C@H](C(=O)c2c(c1)O)O

Computed Properties

• Complexity: 445
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 1
• XLogP3: 1.1

Literature

• Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury.

  Toxicology letters 20170515

• Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer.

  Environmental toxicology 20170401

• Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways.

  Chemico-biological interactions 20161025

• Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140401

• Synthesis and characterization of ampelopsin glucosides using dextransucrase from Leuconostoc mesenteroides B-1299CB4: glucosylation enhancing physicochemical properties.

  Enzyme and microbial technology 20121210

• Ampelopsin inhibits H₂O₂-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase-1.

  Phytotherapy research : PTR 20120701

• Ampelopsin sodium exhibits antitumor effects against bladder carcinoma in orthotopic xenograft models.

  Anti-cancer drugs 20120701

• Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival.

  British journal of pharmacology 20120701

• Spectroscopic studies on the interaction between an anticancer drug ampelopsin and bovine serum albumin.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120215

• Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.

  International immunopharmacology 20120101

• Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice.

  PloS one 20120101

• Vitisin B, a resveratrol tetramer, inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells.

  Toxicology and applied pharmacology 20111015

• Regioselective reactions for programmable resveratrol oligomer synthesis.

  Nature 20110623

• Organic chemistry: Triumph for unnatural synthesis.

  Nature 20110622

• Development and application of high-performance liquid chromatography for the study of ampelopsin pharmacokinetics in rat plasma using cloud-point extraction.

  Journal of separation science 20110101

• cis-Ampelopsin E, a stilbene isolated from the seeds of Paeonia suffruticosa, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages via blockade of nuclear factor-kappa B signaling pathway.

  Biological & pharmaceutical bulletin 20110101

• Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.

  Molecules (Basel, Switzerland) 20100324

• [Reversal effect and its mechanism of ampelopsin on multidrug resistance in K562/ADR cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

• Ampelopsin prevents apoptosis induced by H2O2 in MT-4 lymphocytes.

  Planta medica 20080201

• [Study on preparation of ampelopsin liposomes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080101

• [Optimizing the extracting technique of ampelopsin from Ampelopsis cantoniensis Planch by a uniform design method].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060701

• [The chemotaxis effect of ampelopsin on the immunocytes].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060301

• [Inhibitory effects of ampelopsin on angiogenesis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060201

• Improving the solubility of ampelopsin by solid dispersions and inclusion complexes.

  Journal of pharmaceutical and biomedical analysis 20050701

• [Anti-tumor effects of ampelopsin on human lung cancer GLC-82 implanted in nude mice].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041101

• Ampelopsin, a small molecule inhibitor of HIV-1 infection targeting HIV entry.

  Biomedical and environmental sciences : BES 20040601

• [Effects of ampelopsin on invasion and metastasis of B16 mouse melanoma in vivo and in vitro].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031001

• [Anti-invasive and anti-metastatic effect of ampelopsin on melanoma].

  Ai zheng = Aizheng = Chinese journal of cancer 20030401

• [Studies on the chemical constituents from Ampelopsis grossedentata].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020401

• [Determination of ampelopsin in the different parts of Ampelopsis grossedentata in different seasons by RP-HPLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101

• [Study on inhibitory effect of ampelopsin on melanoma by serologic pharmacological method].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010501