27220-47-9 | Econazole

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$26.00	$18.00
25g	98%	in stock	$42.00	$30.00
100g	98%	in stock	$90.00	$63.00
500g	98%	in stock	$251.00	$176.00

Description

• Catalog Number: AI46290
• Chemical Name: Econazole
• CAS Number: 27220-47-9
• Molecular Formula: C18H15Cl3N2O
• Molecular Weight: 381.6835
• MDL Number: MFCD00800993
• SMILES: C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
• NSC Number: 187789

Computed Properties

• Complexity: 379
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Undefined Atom Stereocenter Count: 1
• XLogP3: 5.3

Literature

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• Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1H-pyrazoles.

  Bioorganic & medicinal chemistry 20041015

• The calcium influx pathway in rat olfactory ensheathing cells shows TRPC channel pharmacology.

  Brain research 20041008

• Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.

  Naunyn-Schmiedeberg's archives of pharmacology 20041001

• P2Y2-receptor-mediated activation of a contralateral, lanthanide-sensitive calcium entry pathway in the human airway epithelium.

  British journal of pharmacology 20040901

• Imidazole analogues of fluoxetine, a novel class of anti-Candida agents.

  Journal of medicinal chemistry 20040729

• Usage of antifungal drugs for therapy of genital Candida infections, purchased as over-the-counter products or by prescription: I. Analyses of a unique database.

  Infectious diseases in obstetrics and gynecology 20040601

• Epidermal growth factor inhibits 14C-alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells: involvement of PLC/PKC, p44/42 MAPK, and cPLA2.

  Journal of cellular physiology 20040501

• Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activation: inhibitory action of docosahexaenoic acid.

  FEBS letters 20040423

• Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors.

  Chemico-biological interactions 20040415

• Antioxidative natural product protect against econazole-induced liver injuries.

  Toxicology 20040301

• Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines.

  The Journal of biological chemistry 20040220

• Dermatophyte-related granular parakeratosis.

  The American Journal of dermatopathology 20040201

• Co-isolation of Trichosporon inkin and Candida parapsilosis from a scalp white piedra case.

  Medical mycology 20040201

• Characteristics and a functional implication of Ca(2+)-activated K(+) current in mouse aortic endothelial cells.

  Pflugers Archiv : European journal of physiology 20040101

• A population-based case-control teratological study of vaginal econazole treatment during pregnancy.

  European journal of obstetrics, gynecology, and reproductive biology 20031210

• Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery.

  Biochemical pharmacology 20031201

• Experimental evaluation of antifungal and antiseptic agents against Rhodotorula spp.

  Mycoses 20031201

• The role of calcium channels in substance P-induced contractile response in the rat iris.

  Peptides 20031201

• Identification and prediction of promiscuous aggregating inhibitors among known drugs.

  Journal of medicinal chemistry 20031009

• A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis.

  The British journal of ophthalmology 20031001

• Enlarging pigmented patches on the hand.

  International journal of dermatology 20031001

• Candidemia and the susceptibility pattern of Candida isolates in blood.

  Saudi medical journal 20031001

• Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria.

  International journal of dermatology 20030901

• Intracellular mediators of granulysin-induced cell death.

  Journal of immunology (Baltimore, Md. : 1950) 20030901

• Effects of Toona sinensis leaf extract on lipolysis in differentiated 3T3-L1 adipocytes.

  The Kaohsiung journal of medical sciences 20030801

• Ligand-activated signal transduction in the 2-cell embryo.

  Biology of reproduction 20030701

• Effects of cytochrome P450 inhibitors on agonist-induced Ca2+ responses and production of NO and PGI2 in vascular endothelial cells.

  Molecular and cellular biochemistry 20030601

• A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20030501

• Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects.

  Journal of veterinary pharmacology and therapeutics 20030201

• [The problem of otomycosis treatment].

  Voenno-meditsinskii zhurnal 20030201

• Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane.

  Journal of pharmaceutical sciences 20030101

• [Vulvovaginal candidiasis and sensitivity of pathogens to antimycotics].

  Ceska gynekologie 20030101

• Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5-dichlorophenylcarbamate) chiral stationary phase.

  Biomedical chromatography : BMC 20030101

• Effect of epidermal growth factor on phosphate uptake in renal proximal tubule cells: involvement of PKC, MAPK, and cPLA2.

  Kidney & blood pressure research 20030101

• Ciclopiroxolamine: in vitro antifungal activity against clinical yeast isolates.

  International journal of antimicrobial agents 20021101

• Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.

  Microbiology (Reading, England) 20021001

• Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purging.

  Experimental hematology 20021001

• Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.

  The Journal of pharmacology and experimental therapeutics 20020901

• Ascorbyl free radical and dehydroascorbate formation in rat liver endoplasmic reticulum.

  Journal of bioenergetics and biomembranes 20020801

• Assessing pregnancy risks of azole antifungals using a high throughput aromatase inhibition assay.

  Endocrine research 20020801

• Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells.

  Clinical and experimental pharmacology & physiology 20020701

• Bradykinin induces a calcium-store- dependent calcium influx in mouse mesangial cells.

  Nephron 20020601

• Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury.

  Planta medica 20020601

• Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.

  The Biochemical journal 20020515

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Purging of contaminating breast cancer cells from hematopoietic progenitor cell preparations using activation enhanced cell death.

  Breast cancer research and treatment 20020401

• (2-Arylhydrazonomethyl)-substituted xanthones as antimycotics: synthesis and fungistatic activity against Candida species.

  European journal of medicinal chemistry 20020301

• Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis.

  Journal of oral science 20020301

• [Candidal vulvovaginitis: an epidemiological survey among immigrant prostitutes].

  Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20020301

• Strategy for the development of automated methods involving dialysis and trace enrichment as on-line sample preparation for the determination of basic drugs in plasma by liquid chromatography.

  Journal of chromatography. A 20020301

• Comparative study of the enantiomeric resolution of chiral antifungal drugs econazole, miconazole and sulconazole by HPLC on various cellulose chiral columns in normal phase mode.

  Journal of pharmaceutical and biomedical analysis 20020115

• Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1.

  British journal of pharmacology 20011001

• In vitro activity of 6 antifungal agents on candida species isolated as causative agents from vaginal and other clinical specimens.

  Saudi medical journal 20011001

• Sertaconazole: in-vitro antifungal activity against vaginal and other superficial yeast isolates.

  Journal of chemotherapy (Florence, Italy) 20011001

• Fendiline mobilizes intracellular Ca2+ in Chang liver cells.

  Clinical and experimental pharmacology & physiology 20010901

• Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs.

  Fresenius' journal of analytical chemistry 20010801

• Mechanisms and modulation of formyl-methionyl-leucyl-phenylalanine (fMLP)-induced Ca2+ mobilization in human neutrophils.

  International immunopharmacology 20010701

• Fatty acids inhibit anion secretion in rat colon: apical and basolateral action sites.

  Pflugers Archiv : European journal of physiology 20010701

• [Invasive rhinocerebral aspergillosis occurred during myelosuppressive phase after chemotherapy: a case report and literature review].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010701

• Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis.

  Biochemical pharmacology 20010615

• Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron.

  American journal of physiology. Endocrinology and metabolism 20010601

• Comparison of in vitro activities of amphotericin, clotrimazole, econazole, miconazole, and nystatin against Fusarium oxysporum.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20010501

• Antifungal and immunomodulating activities of 1,4-benzothiazine azole derivatives: review.

  Journal of chemotherapy (Florence, Italy) 20010201

• [New developments in medical mycology].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20010201

• Systemic Candida infection in University hospital 1997-1999: the distribution of Candida biotypes and antifungal susceptibility patterns.

  Mycopathologia 20010101

• Cellular mechanism of calcification and its prevention in glutaraldehyde treated vascular tissue.

  Zeitschrift fur Kardiologie 20010101

• [Antifungal drug susceptibility of Candida causing oropharyngeal candidiasis in HIV infected patients].

  Dakar medical 20010101

• Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis.

  FEMS microbiology letters 20001115

• Synergy between 6-amino-2-n-pentylthiobenzothiazole and ergosterol biosynthesis-inhibiting antimycotics against Candida albicans in vitro.

  International journal of antimicrobial agents 20000701

• In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp.

  The Journal of antimicrobial chemotherapy 19951001

• In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.

  Mycopathologia 19920401

• Antifungal activity of the allylamine derivative terbinafine in vitro.

  Antimicrobial agents and chemotherapy 19870901

• Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones.

  Journal of medicinal chemistry 19870801