274-95-3 | Imidazo[1,2-a]pyrimidine

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$15.00	$10.00
1g	97%	in stock	$33.00	$23.00
5g	97%	in stock	$46.00	$33.00
10g	97%	in stock	$90.00	$63.00
25g	97%	in stock	$195.00	$137.00

Description

• Catalog Number: AB74745
• Chemical Name: Imidazo[1,2-a]pyrimidine
• CAS Number: 274-95-3
• Molecular Formula: C6H5N3
• Molecular Weight: 119.124
• MDL Number: MFCD06245377
• SMILES: c1ccn2c(n1)ncc2

Computed Properties

• Complexity: 105
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 1.1

Literature

• Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.

  Bioorganic & medicinal chemistry 20120401

• Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.

  Psychopharmacology 20120201

• Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO).

  Journal of medicinal chemistry 20111110

• Structure-activity relationship of 4(5)-aryl-2-amino-1H-imidazoles, N1-substituted 2-aminoimidazoles and imidazo[1,2-a]pyrimidinium salts as inhibitors of biofilm formation by Salmonella typhimurium and Pseudomonas aeruginosa.

  Journal of medicinal chemistry 20110127

• Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents.

  European journal of medicinal chemistry 20101201

• 5-HT1A receptor blockade reverses GABA(A) receptor alpha3 subunit-mediated anxiolytic effects on stress-induced hyperthermia.

  Psychopharmacology 20100801

• Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.

  Organic letters 20061207

• 8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor.

  Bioorganic & medicinal chemistry letters 20060315

• Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine.

  Organic letters 20031211

• Effect of imidazo[1,2-a]pyrimidine derivatives on leukocyte function.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010601