27591-97-5 | 9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%(HPLC)	in stock	$76.00	$53.00
25mg	98%(HPLC)	in stock	$265.00	$185.00
100mg	98%(HPLC)	in stock	$914.00	$640.00

Description

• Catalog Number: AB32218
• Chemical Name: 9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-
• CAS Number: 27591-97-5
• Molecular Formula: C25H34N2O3
• Molecular Weight: 410.5491
• MDL Number: MFCD00866953
• SMILES: CCN(CCOc1ccc2c(c1)C(=O)c1c2ccc(c1)OCCN(CC)CC)CC
• NSC Number: 759311

Computed Properties

• Complexity: 477
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• XLogP3: 4.7

Literature

• Why are most phospholipidosis inducers also hERG blockers?

  Archives of toxicology 20171201

• Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.

  Toxicological sciences : an official journal of the Society of Toxicology 20120501

• SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.

  Bioorganic & medicinal chemistry letters 20120215

• [The antiviral activity of diphenyl derivatives in different model systems].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20120101

• Dose-dependent IFN-stimulating and immunomodulating properties of 6H-indolo[2,3-B] quinoxaline derivatives.

  Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20120101

• [Perspectives of prevention and treatment of herpes symplex with regular recurrence].

  Terapevticheskii arkhiv 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Performance of tiloronoxim and tilorone determination in human blood by HPLC-MS/MS: method validation, uncertainty assessment and its application to a pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

• α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.

  The open medicinal chemistry journal 20100101

• Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines.

  European journal of medicinal chemistry 20090801

• Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

  Annals of the New York Academy of Sciences 20081201

• Simultaneous quantification of tiloronoxim and tilorone in human urine by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081115

• Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.

  Cellular and molecular neurobiology 20081101

• alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.

  British journal of pharmacology 20080301

• DNA binding of tilorone: 1H NMR and calorimetric studies of the intercalation.

  Biochemistry 20070710

• [Interferonogenic activity of amixin analogs and diphenyl derivatives].

  Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20070101

• Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio).

  Fish & shellfish immunology 20060701

• [Individual changes of gene expression in the interferon system in human blood cells due to amixin and cycloferon].

  Voprosy virusologii 20050101

• [Interferon status of patients with non-specific ulcerous colitis and its correction with interferon inducers].

  Terapevticheskii arkhiv 20020101

• [Intestinal microflora in rats under the conditions of a chronic toxic lesion of the liver].

  Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20020101

• Correlations between in vitro effects of preparations of interferon and its inducers on blood cells in patients with multiple sclerosis.

  Bulletin of experimental biology and medicine 20010401

• Antiviral and interferon-inducing properties of interferon inducers administered with prostaglandins.

  Antimicrobial agents and chemotherapy 19800301

• Effects of tilorone hydrochloride on experimental flavivirus infections in mice.

  Acta virologica 19770301

• Antiviral activity of BL-3849A, a low-molecular-weight oral interferon inducer.

  Antimicrobial agents and chemotherapy 19761001

• Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones.

  Journal of medicinal chemistry 19740801

• Antiviral activity and induction of interferon-like substance by quinacrine and acranil.

  Antimicrobial agents and chemotherapy 19730501