2761-09-3 | Hydroxypropyl methacrylate

Packsize	Purity	Availability	Price	Discounted Price
25g	95% (isomers mixture)(stabilized with MEHQ)	in stock	$113.00	$79.00

Description

• Catalog Number: AB32283
• Chemical Name: Hydroxypropyl methacrylate
• CAS Number: 2761-09-3
• Molecular Formula: C7H12O3
• Molecular Weight: 144.1684
• MDL Number: MFCD00051317
• SMILES: CC(=C)C(=O)OCCCO

Computed Properties

• Complexity: 129
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 1.3

Literature

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  Biomacromolecules 20120312

• Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates.

  Biomacromolecules 20120312

• Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates.

  Biomaterials 20120301

• Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties.

  Biomaterials 20120301

• Synthesis and in vitro anti-tumor activity of novel HPMA copolymer-drug conjugates with potential cell surface targeting property for carcinoma cells.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120201

• Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells.

  Biomaterials 20120201

• Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials.

  Biomaterials 20120201

• Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry.

  Bioconjugate chemistry 20111221

• Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.

  Journal of controlled release : official journal of the Controlled Release Society 20110925

• Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers.

  Journal of controlled release : official journal of the Controlled Release Society 20110730

• Modifying the body distribution of HPMA-based copolymers by molecular weight and aggregate formation.

  Biomacromolecules 20110711

• HPMA based amphiphilic copolymers mediate central nervous effects of domperidone.

  Macromolecular rapid communications 20110518

• Effect of film thickness on the antifouling performance of poly(hydroxy-functional methacrylates) grafted surfaces.

  Langmuir : the ACS journal of surfaces and colloids 20110419

• Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110418

• Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications.

  Molecular pharmacology 20110401

• Light induced drug delivery into cancer cells.

  Biomaterials 20110201

• Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor-bearing mice.

  Biomacromolecules 20110110

• Immobilization of chloroperoxidase onto highly hydrophilic polyethylene chains via bio-conjugation: catalytic properties and stabilities.

  Bioresource technology 20110101

• Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions.

  Journal of biomedical science 20110101

• Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical polymerization.

  Langmuir : the ACS journal of surfaces and colloids 20101116

• HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury.

  Stem cells and development 20101001

• Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake.

  Biomacromolecules 20100913

• HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release.

  Molecular pharmaceutics 20100802

• Synthesis, characterization and enhanced photoconductivity from a mesoporous titania on dye doping.

  Analytica chimica acta 20100726

• Functional diversification of AGAMOUS lineage genes in regulating tomato flower and fruit development.

  Journal of experimental botany 20100601

• Langmuir-Blodgett films of biocompatible poly(HPMA)-block-poly(lauryl methacrylate) and poly(HPMA)-random-poly(lauryl methacrylate): influence of polymer structure on membrane formation and stability.

  Langmuir : the ACS journal of surfaces and colloids 20100420

• Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis.

  Bioorganic & medicinal chemistry 20100401

• Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers.

  Journal of biomaterials science. Polymer edition 20100101

• Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy.

  Arthritis research & therapy 20100101

• HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity.

  Journal of controlled release : official journal of the Controlled Release Society 20091116

• Hyperbranched polyamidoamines containing beta-cyclodextrin for controlled release of chlorambucil.

  Macromolecular bioscience 20091110

• Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.

  Macromolecular bioscience 20091110

• Synthesis and bioactivity of poly(HPMA)-lysozyme conjugates: the use of novel thiazolidine-2-thione coupling chemistry.

  Organic & biomolecular chemistry 20090907

• Nortriptyline for smoking cessation: release and human skin diffusion from patches.

  International journal of pharmaceutics 20090813

• Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR.

  Pharmaceutical research 20090701

• HPMA-based polymer conjugates with drug combination.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628

• N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents.

  International journal of antimicrobial agents 20090501

• Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer.

  Human gene therapy 20090301

• Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.

  Macromolecular bioscience 20090109

• Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells.

  Molecular pharmaceutics 20090101

• Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis.

  Pharmaceutical research 20081201

• Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats.

  Pharmaceutical research 20081201

• One-pot conversion of RAFT-generated multifunctional block copolymers of HPMA to doxorubicin conjugated acid- and reductant-sensitive crosslinked micelles.

  Biomacromolecules 20081101

• From defined reactive diblock copolymers to functional HPMA-based self-assembled nanoaggregates.

  Biomacromolecules 20081101

• HPMA copolymer-doxorubicin-gadolinium conjugates: synthesis, characterization, and in vitro evaluation.

  Macromolecular bioscience 20080811

• Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates.

  Macromolecular bioscience 20080513

• New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting.

  Journal of controlled release : official journal of the Controlled Release Society 20080421

• Doxorubicin release is not a prerequisite for the in vitro cytotoxicity of HPMA-based pharmaceuticals: in vitro effect of extra drug-free GlyPheLeuGly sequences.

  Journal of controlled release : official journal of the Controlled Release Society 20080421

• Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs.

  International journal of pharmaceutics 20080303

• Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers.

  Biomacromolecules 20080201

• Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats.

  Pharmaceutical research 20080101

• Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice.

  Molecular pharmaceutics 20080101

• Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes.

  PLoS pathogens 20080101

• Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates.

  Pharmaceutical research 20071201

• [Pilot study of a cell membrane like biomimetic drug-eluting coronary stent].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20070601

• Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems.

  Journal of controlled release : official journal of the Controlled Release Society 20070226

• Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.

  Journal of controlled release : official journal of the Controlled Release Society 20070212

• Designing polymer conjugates as lysosomotropic nanomedicines.

  Biochemical Society transactions 20070201

• Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis.

  Arthritis research & therapy 20070101

• Affinity separation of immunoglobulin G subclasses on dye attached poly(hydroxypropyl methacrylate) beads.

  International journal of biological macromolecules 20061115

• Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification.

  Journal of controlled release : official journal of the Controlled Release Society 20060928

• Polymeric conjugates of mono- and bi-cyclic alphaVbeta3 binding peptides for tumor targeting.

  Journal of controlled release : official journal of the Controlled Release Society 20060828

• Enhancement of ethyl propionate synthesis by poly (AAc-co-HPMA-cl-MBAm)-immobilized Pseudomonas aeruginosa MTCC-4713, exposed to Hg2+ and NH4+ ions.

  Acta microbiologica et immunologica Hungarica 20060601

• Hybrid hydrogels self-assembled from HPMA copolymers containing peptide grafts.

  Macromolecular bioscience 20060314

• Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer.

  Journal of controlled release : official journal of the Controlled Release Society 20060110

• Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy.

  Nuclear medicine and biology 20060101

• Macrophage targeted N-(2-hydroxypropyl)methacrylamide conjugates for magnetic resonance imaging.

  Molecular pharmaceutics 20060101

• Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.

  Journal of controlled release : official journal of the Controlled Release Society 20051210

• Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation.

  Journal of controlled release : official journal of the Controlled Release Society 20050902

• Targeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050901

• Induction of systemic antitumour resistance with targeted polymers.

  Scandinavian journal of immunology 20050701

• Polymer therapeutics designed for a combination therapy of hormone-dependent cancer.

  Angewandte Chemie (International ed. in English) 20050627

• Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck.

  Journal of drug targeting 20050401

• Intracellular targeting of polymer-bound drugs for cancer chemotherapy.

  Advanced drug delivery reviews 20050227

• Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate.

  Neuroscience letters 20050201

• Oligopeptides as targeting structures in cancer theraPY.

  Journal of controlled release : official journal of the Controlled Release Society 20050103

• Final report of the safety assessment of methacrylate ester monomers used in nail enhancement products.

  International journal of toxicology 20050101

• Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours.

  Journal of inorganic biochemistry 20041001

• The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study.

  Pharmaceutical research 20041001

• Aggregation properties of a HPMA-camptothecin copolymer in isotonic solutions.

  Biophysical chemistry 20040801

• The effect of the processing and formulation parameters on the size of nanoparticles based on block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) with and without hydrolytically sensitive groups.

  Biomaterials 20040501

• Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470.

  Nature medicine 20040301

• Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.

  Journal of controlled release : official journal of the Controlled Release Society 20040220

• Polymer therapeutics - Sixth International Symposium: from laboratory to clinical practice.

  IDrugs : the investigational drugs journal 20040201

• A novel crosslinkable polymer as drug-loaded coating for biomedical device.

  Journal of materials science. Materials in medicine 20040201

• Prevention of gliotic scar formation by NeuroGel allows partial endogenous repair of transected cat spinal cord.

  Journal of neuroscience research 20040115

• HPMA copolymer-1,5-diazaanthraquinone conjugates as novel anticancer therapeutics.

  Journal of drug targeting 20040101

• Starlike vs. classic macromolecular prodrugs: two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs.

  Pharmaceutical research 20031001

• [Synthesis and characterization of biomacromolecular conjugates for magnetic resonance imaging].

  Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20030901

• Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data.

  Journal of controlled release : official journal of the Controlled Release Society 20030828

• Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells.

  Journal of controlled release : official journal of the Controlled Release Society 20030828

• Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates.

  Photochemistry and photobiology 20030601

• Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells.

  Pharmaceutical research 20030501

• HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity.

  Journal of controlled release : official journal of the Controlled Release Society 20030221

• Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells.

  Bioconjugate chemistry 20030101

• HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer.

  Advances in experimental medicine and biology 20030101

• PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combination.

  Bioconjugate chemistry 20030101

• Polyacetal-doxorubicin conjugates designed for pH-dependent degradation.

  Bioconjugate chemistry 20030101

• HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluation.

  Journal of drug targeting 20021101

• Synthesis of hydroxypropyl methacrylate/polysaccharide graft copolymers as matrices for controlled release tablets.

  Drug development and industrial pharmacy 20021001

• Immunomodulating activities of soluble synthetic polymer-bound drugs.

  Advanced drug delivery reviews 20020913

• Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation.

  Bioorganic & medicinal chemistry 20020901

• The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells.

  Pharmaceutical research 20020801

• HPMA-hydrogels containing cytostatic drugs. Kinetics of the drug release and in vivo efficacy.

  Journal of controlled release : official journal of the Controlled Release Society 20020517

• Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates.

  Pharmaceutical research 20020401

• In vitro and in vivo effect of HPMA copolymer-bound doxorubicin targeted to transferrin receptor of B-cell lymphoma 38C13.

  Journal of drug targeting 20020201

• Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs.

  Journal of controlled release : official journal of the Controlled Release Society 20020117

• Design of novel bioconjugates for targeted drug delivery.

  Journal of controlled release : official journal of the Controlled Release Society 20020117

• Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect.

  Bioconjugate chemistry 20020101

• Antisense oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus.

  Bioconjugate chemistry 20020101

• Use of hydrophilic hydroxypropyl methacrylate/ethylene glycol methacrylate packing material in size-exclusion chromatography.

  Journal of AOAC International 20020101

• N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs.

  Journal of controlled release : official journal of the Controlled Release Society 20011213

• Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin.

  Journal of controlled release : official journal of the Controlled Release Society 20010810

• Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• Preparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions.

  Journal of controlled release : official journal of the Controlled Release Society 20010706

• New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties.

  Journal of controlled release : official journal of the Controlled Release Society 20010518

• Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.

  Journal of controlled release : official journal of the Controlled Release Society 20010428

• Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.

  Anti-cancer drugs 20010401

• The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine.

  Journal of drug targeting 20010401

• Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.

  Gene therapy 20010301

• [Study of 'living' radical polymerization by FTIR in situ].

  Guang pu xue yu guang pu fen xi = Guang pu 20010201

• The effect of two hydrophilic monomers on the water uptake of a heterocyclic methacrylate system.

  Biomaterials 20010101

• Crosslinkable coatings from phosphorylcholine-based polymers.

  Biomaterials 20010101

• Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers.

  Bioconjugate chemistry 20010101

• Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.

  PDA journal of pharmaceutical science and technology 20010101

• N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation.

  Bioconjugate chemistry 20010101

• Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells.

  Bioconjugate chemistry 20010101