287383-59-9 | 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$20.00	$14.00
5mg	99%	in stock	$36.00	$25.00
10mg	99%	in stock	$49.00	$34.00
50mg	99%	in stock	$122.00	$85.00

Description

• Catalog Number: AB34984
• Chemical Name: 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-
• CAS Number: 287383-59-9
• Molecular Formula: C18H18N2O4
• Molecular Weight: 326.3465
• MDL Number: MFCD00386477
• SMILES: ONC(=O)CCCCCN1C(=O)c2cccc3c2c(C1=O)ccc3

Computed Properties

• Complexity: 477
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 2

Literature

• Scriptaid effects on breast cancer cell lines.

  Journal of cellular physiology 20121001

• Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos.

  Biology of reproduction 20111101

• AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5.

  The Journal of biological chemistry 20110506

• Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors.

  Hepatology (Baltimore, Md.) 20110301

• Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos.

  The Journal of reproduction and development 20110201

• Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.

  Experimental biology and medicine (Maywood, N.J.) 20101101

• HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity.

  Journal of cellular and molecular medicine 20100801

• Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines.

  International journal of molecular medicine 20100801

• Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.

  Biochemical and biophysical research communications 20100319

• Chemical phylogenetics of histone deacetylases.

  Nature chemical biology 20100301

• Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos.

  Cellular reprogramming 20100201

• Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation.

  International journal of molecular medicine 20100101

• Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

  Nature chemical biology 20100101

• Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells.

  International immunopharmacology 20091001

• Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer.

  Biology of reproduction 20090901

• The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice.

  Reproduction (Cambridge, England) 20090801

• Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages.

  Archives of pharmacal research 20090401

• Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells.

  International journal of oncology 20081001

• Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes.

  Endocrinology 20071001

• Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro.

  The Journal of parasitology 20070601

• Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy.

  Circulation 20060606

• A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells.

  International journal of molecular medicine 20060201

• Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid.

  Cellular and molecular biology (Noisy-le-Grand, France) 20050905

• Induction of human gamma globin gene expression by histone deacetylase inhibitors.

  Blood 20040115

• (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.

  Bioorganic & medicinal chemistry letters 20040105

• A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine.

  Breast cancer research and treatment 20031001

• A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.

  Cancer research 20000615