287714-41-4 | Rosuvastatin

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$72.00	$51.00
10mg	≥98%	in stock	$125.00	$88.00
50mg		in stock	$253.00	$177.00
100mg		in stock	$305.00	$213.00

Description

• Catalog Number: AB35130
• Chemical Name: Rosuvastatin
• CAS Number: 287714-41-4
• Molecular Formula: C22H28FN3O6S
• Molecular Weight: 481.5376
• MDL Number: MFCD18783208
• SMILES: O[C@@H](C[C@H](CC(=O)O)O)/C=C/c1c(nc(nc1c1ccc(cc1)F)N(S(=O)(=O)C)C)C(C)C

Computed Properties

• Complexity: 767
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 33
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 10
• XLogP3: 1.6

Literature

• Ascorbic acid supplementation partially prevents the delayed reproductive development in juvenile male rats exposed to rosuvastatin since prepuberty.

  Reproductive toxicology (Elmsford, N.Y.) 20171001

• Rosuvastatin safety: An experimental study of myotoxic effects and mitochondrial alterations in rats.

  Toxicology letters 20170104

• Beneficial Effects of Sarpogrelate and Rosuvastatin in High Fat Diet/Streptozotocin-Induced Nephropathy in Mice.

  PloS one 20160101

• Optimized Hepatocyte-Like Cells with Functional Drug Transporters Directly-Reprogrammed from Mouse Fibroblasts and their Potential in Drug Disposition and Toxicology.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20160101

• Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20151201

• Clinical drug interaction profile of idelalisib in healthy subjects.

  Journal of clinical pharmacology 20150801

• Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20140901

• Disposition of atorvastatin, rosuvastatin, and simvastatin in oatp1b2-/- mice and intraindividual variability in human subjects.

  Journal of clinical pharmacology 20121101

• Intronic variants in SLCO1B1 related to statin-induced myopathy are associated with the low-density lipoprotein cholesterol response to statins in Chinese patients with hyperlipidaemia.

  Pharmacogenetics and genomics 20121101

• Rosuvastatin improves vascular function of arteriovenous fistula in a diabetic rat model.

  Journal of vascular surgery 20121101

• The role of a basolateral transporter in rosuvastatin transport and its interplay with apical breast cancer resistance protein in polarized cell monolayer systems.

  Drug metabolism and disposition: the biological fate of chemicals 20121101

• Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia.

  Journal of lipid research 20121101

• Total cholesterol content of erythrocyte membranes is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin.

  Upsala journal of medical sciences 20121101

• Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20121001

• Additive effect of homocysteine- and cholesterol-lowering therapy on endothelium-dependent vasodilation in patients with cardiovascular disease.

  Cardiovascular therapeutics 20121001

• Effect of statins on coronary bifurcation atherosclerosis: an intravascular ultrasound virtual histology study.

  The international journal of cardiovascular imaging 20121001

• Single-dose, 2-way crossover, bioequivalence study of two rosuvastatin formulations in normal healthy subjects under fasting conditions.

  International journal of clinical pharmacology and therapeutics 20121001

• Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20121001

• Effect of rosuvastatin on the echolucency of the common carotid intima-media in low-risk individuals: the METEOR trial.

  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20121001

• Long-term effects of ezetimibe-plus-statin therapy on low-density lipoprotein cholesterol levels as compared with double-dose statin therapy in patients with coronary artery disease.

  Atherosclerosis 20121001

• Rosuvastatin may modulate insulin signaling and inhibit atherogenesis beyond its plasma cholesterol-lowering effect in insulin-resistant mice.

  Cardiovascular drugs and therapy 20121001

• Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: role of iNOS and VEGF.

  European journal of pharmacology 20120915

• Effects of rosuvastatin versus pravastatin on low-density lipoprotein diameter in HIV-1-infected patients receiving ritonavir-boosted protease inhibitor.

  AIDS (London, England) 20120910

• The therapeutic effect of rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats.

  Journal of cellular and molecular medicine 20120901

• Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.

  Xenobiotica; the fate of foreign compounds in biological systems 20120901

• Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.

  European heart journal 20120901

• Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20120901

• Comparison of the effects of different statins and doses on lipid levels in patients with diabetes: results from VOYAGER.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20120901

• Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression.

  Oncology reports 20120901

• Pentraxin-3 in chronic heart failure: the CORONA and GISSI-HF trials.

  European journal of heart failure 20120901

• Effect of rosuvastatin monotherapy or in combination with fenofibrate or ω-3 fatty acids on lipoprotein subfraction profile in patients with mixed dyslipidaemia and metabolic syndrome.

  International journal of clinical practice 20120901

• Chronic exposure to environmental contaminant nonylphenol exacerbates adenine-induced chronic renal insufficiency: role of signaling pathways and therapeutic impact of rosuvastatin.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

• Caveolin-1-eNOS/Hsp70 interactions mediate rosuvastatin antifibrotic effects in neonatal obstructive nephropathy.

  Nitric oxide : biology and chemistry 20120815

• Balancing the cardiometabolic benefits and risks of statins.

  Lancet (London, England) 20120811

• Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial.

  Lancet (London, England) 20120811

• Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.

  British journal of clinical pharmacology 20120801

• Rosuvastatin suppresses the liver microsomal CYP2C11 and CYP2C6 expression in male Wistar rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20120801

• MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression.

  Clinical science (London, England : 1979) 20120801

• Pravastatin inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level.

  Metabolism: clinical and experimental 20120801

• Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed on a high-fat diet.

  Clinical science (London, England : 1979) 20120801

• Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin.

  Journal of cardiovascular pharmacology 20120801

• Utility of drug depletion-time profiles in isolated hepatocytes for accessing hepatic uptake clearance: identifying rate-limiting steps and role of passive processes.

  Drug metabolism and disposition: the biological fate of chemicals 20120801

• CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation.

  The American journal of pathology 20120801

• Predictive value of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio for the prevention of stroke recurrence in Japanese patients treated with rosuvastatin.

  Clinical drug investigation 20120801

• Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia.

  Atherosclerosis 20120801

• Effect of intensive lipid-lowering treatment compared to moderate lipid-lowering treatment with rosuvastatin on endothelial function in high risk patients.

  International journal of cardiology 20120726

• Rosuvastatin combined with ramipril significantly reduced atheroma volume by anti-inflammatory mechanism: comparative analysis with rosuvastatin alone by intravascular ultrasound.

  International journal of cardiology 20120712

• Cardioprotective effects of rosuvastatin and carvedilol on delayed cardiotoxicity of doxorubicin in rats.

  Toxicology mechanisms and methods 20120701

• Rosuvastatin improves pulse wave reflection by restoring endothelial function.

  Microvascular research 20120701

• The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin.

  Journal of lipid research 20120701

• Simultaneous and spontaneous bilateral quadriceps tendons rupture.

  American journal of physical medicine & rehabilitation 20120701

• Deterioration of glucose homeostasis in type 2 diabetic patients one year after beginning of statins therapy.

  Atherosclerosis 20120701

• Non-every day statin administration--a literature review.

  European journal of internal medicine 20120701

• Cholesterol level goal attainment with statins: clinical management guideline recommendations versus management in actual clinical practice.

  Pharmacotherapy 20120701

• Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in female patients with non-ST-segment elevation acute coronary syndrome.

  Chinese medical journal 20120701

• Rosuvastatin slows the development of diastolic dysfunction in calcific aortic stenosis.

  The Journal of heart valve disease 20120701

• Pharmacokinetic interactions between clopidogrel and rosuvastatin: effects on vascular protection in subjects with coronary heart disease.

  International journal of cardiology 20120628

• The ability of high dose rosuvastatin to improve plaque composition in non-intervened coronary arteries: rationale and design of the Integrated Biomarker and Imaging Study-3 (IBIS-3).

  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20120620

• Comparison of effects of atorvastatin (20 mg) versus rosuvastatin (10 mg) therapy on mild coronary atherosclerotic plaques (from the ARTMAP trial).

  The American journal of cardiology 20120615

• Change in near-infrared spectroscopy of a coronary artery after 1-year treatment with high dose rosuvastatin.

  International journal of cardiology 20120614

• [Effects of domestic rosuvastatin on coronary plaque in patients with mild-to-moderate coronary artery stenosis as evaluated by virtual histology-intravascular ultrasound].

  Zhonghua yi xue za zhi 20120612

• [Effectiveness of generic rosuvastatin in patients with ischaemic cerebrovascular disease].

  Orvosi hetilap 20120603

• Prescribing high-dose lipid-lowering therapy early to avoid subsequent cardiovascular events: is this a cost-effective strategy?

  European journal of preventive cardiology 20120601

• Steady-state pharmacokinetic interactions of darunavir/ritonavir with lipid-lowering agent rosuvastatin.

  Journal of clinical pharmacology 20120601

• Multiple imputation of missing repeated outcome measurements did not add to linear mixed-effects models.

  Journal of clinical epidemiology 20120601

• Biologically implausible carotid intima-media thickness measurement values: effects on rate of change over time.

  Current medical research and opinion 20120601

• A review of time courses and predictors of lipid changes with fenofibric acid-statin combination.

  Cardiovascular drugs and therapy 20120601

• Rosuvastatin effect on intima media thickness in adult vs elderly patients.

  Frontiers in bioscience (Elite edition) 20120601

• Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

  Journal of medicinal chemistry 20120524

• Severe hypertriglyceridaemia. Treatment with plasmapheresis.

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20120514

• Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: effect of statins on let-7i and Toll-like receptor 4 signal.

  Immunobiology 20120501

• [Extrapolating the NNT jeopardises biostatistics and leads to immortality].

  Atencion primaria 20120501

• Effects of rosuvastatin and atorvastatin on glycaemic control in Type 2 diabetes---the CORALL study.

  Diabetic medicine : a journal of the British Diabetic Association 20120501

• The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*.

  Journal of internal medicine 20120501

• Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.

  Journal of neurotrauma 20120501

• Comparison of lipid-modifying efficacy of rosuvastatin versus atorvastatin in patients with acute coronary syndrome (from the LUNAR study).

  The American journal of cardiology 20120501

• Relationship of lipoprotein-associated phospholipase A₂ mass and activity with incident vascular events among primary prevention patients allocated to placebo or to statin therapy: an analysis from the JUPITER trial.

  Clinical chemistry 20120501

• Sample size requirements in trials using repeated measurements and the impact of trial design.

  Current medical research and opinion 20120501

• Statins and glycaemic control--a cause for concern?

  Diabetic medicine : a journal of the British Diabetic Association 20120501

• Rosuvastatin might have an effect on C-reactive protein but not on rheumatoid disease activity: Tayside randomized controlled study.

  Scottish medical journal 20120501

• On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin).

  Journal of the American College of Cardiology 20120424

• The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20120417

• Lipid-altering efficacy of ezetimibe/simvastatin 10/20 mg compared to rosuvastatin 10 mg in high-risk patients with and without type 2 diabetes mellitus inadequately controlled despite prior statin monotherapy.

  Cardiovascular therapeutics 20120401

• Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice.

  Arthritis and rheumatism 20120401

• Understanding the interplay of drug transporters involved in the disposition of rosuvastatin in the isolated perfused rat liver using a physiologically-based pharmacokinetic model.

  Xenobiotica; the fate of foreign compounds in biological systems 20120401

• Effects of rosuvastatin on serum asymmetric dimethylarginine levels and atrial structural remodeling in atrial fibrillation dogs.

  Pacing and clinical electrophysiology : PACE 20120401

• One-year efficacy and safety of rosuvastatin + fenofibric acid combination therapy in patients with mixed dyslipidemia: evaluation of dose response.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20120401

• Renal safety of intensive cholesterol-lowering treatment with rosuvastatin: a retrospective analysis of renal adverse events among 40,600 participants in the rosuvastatin clinical development program.

  Atherosclerosis 20120401

• Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.

  Circulation. Cardiovascular genetics 20120401

• Effects of HMG-CoA reductase inhibitor on experimental autoimmune myocarditis.

  Cardiovascular drugs and therapy 20120401

• Targeting HDL-cholesterol to reduce residual cardiovascular risk.

  Current opinion in lipidology 20120401

• Reversible dysphasia and statins.

  Journal of Korean medical science 20120401

• Rosuvastatin attenuates mucus secretion in a murine model of chronic asthma by inhibiting the gamma-aminobutyric acid type A receptor.

  Chinese medical journal 20120401

• Atorvastatin, not rosuvastatin, improves cardiac function in heart failure: a meta-analysis of randomized trials.

  International journal of cardiology 20120308

• Manual or semi-automated edge detection of the maximal far wall common carotid intima-media thickness: a direct comparison.

  Journal of internal medicine 20120301

• The effects of rosuvastatin and the CYP51A1 inhibitor LEK-935 on the proteome of primary human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20120301

• In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20120301

• Rosuvastatin elicits KDR-dependent vasculogenic response of human placental stem cells through PI3K/AKT pathway.

  Pharmacological research 20120301

• Daily and intermittent rosuvastatin 5 mg therapy in statin intolerant patients: an observational study.

  Current medical research and opinion 20120301

• Non-lipid effects of rosuvastatin-fenofibrate combination therapy in high-risk Asian patients with mixed hyperlipidemia.

  Atherosclerosis 20120301

• Therapeutic options for statin-intolerant patients.

  Current medical research and opinion 20120301

• The work-up for mixed hyperlipidemia: a case study.

  The Journal of family practice 20120301

• Effect of rosuvastatin on obesity-induced cardiac oxidative stress in Wistar rats--a preliminary study.

  Indian journal of experimental biology 20120301

• The importance of green chemistry in process research and development.

  Chemical Society reviews 20120221

• Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

  Journal of medicinal chemistry 20120209

• Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.

  The Journal of pharmacology and experimental therapeutics 20120201

• Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20120201

• Rosuvastatin blocks hERG current and prolongs cardiac repolarization.

  Journal of pharmaceutical sciences 20120201

• Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia.

  The American journal of cardiology 20120201

• Effect of pitavastatin vs. rosuvastatin on international normalized ratio in healthy volunteers on steady-state warfarin.

  Current medical research and opinion 20120201

• High-sensitivity C-reactive protein, statin therapy, and risks of atrial fibrillation: an exploratory analysis of the JUPITER trial.

  European heart journal 20120201

• Pharmacogenetic determinants of statin-induced reductions in C-reactive protein.

  Circulation. Cardiovascular genetics 20120201

• [HDL level or HDL function as the primary target in preventive cardiology].

  Herz 20120201

• My patient has an elevated hs-CRP. What does this mean? What should I do now?

  JPMA. The Journal of the Pakistan Medical Association 20120201

• Impact of 10 mg rosuvastatin daily or alternate-day on lipid profile and inflammatory markers.

  Clinica chimica acta; international journal of clinical chemistry 20120118

• A meta-analysis of randomized head-to-head trials of atorvastatin versus rosuvastatin for reductions in C-reactive protein.

  International journal of cardiology 20120112

• Enhancement of antioxidant defense mechanism by pitavastatin and rosuvastatin on obesity-induced oxidative stress in Wistar rats.

  Toxicology mechanisms and methods 20120101

• Short-term statin treatment does not prevent ischemia and reperfusion-induced endothelial dysfunction in humans.

  Journal of cardiovascular pharmacology 20120101

• Extensive or restricted ultrasound protocols to measure carotid intima-media thickness: analysis of completeness rates and impact on observed rates of change over time.

  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20120101

• Loss of the preconditioning effect of rosuvastatin during sustained therapy: a human in vivo study.

  American journal of physiology. Heart and circulatory physiology 20120101

• Cost-effectiveness of rosuvastatin 20 mg for the prevention of cardiovascular morbidity and mortality: a Swedish economic evaluation of the JUPITER trial.

  Journal of medical economics 20120101

• Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial.

  Clinical chemistry 20120101

• Effect of intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness in Japanese patients: Justification for Atherosclerosis Regression Treatment (JART) study.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Intensive lipid-lowering therapy with statins for primary prevention.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

  Analytical and bioanalytical chemistry 20120101

• Statins, plasma proprotein convertase subtilisin/kexin type 9 concentrations, and LDL lowering.

  Clinical chemistry 20120101

• Measuring carotid artery intima-media thickness: simplicity versus complexity?

  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20120101

• Rosuvastatin preserves renal structure following unilateral ureteric obstruction in the neonatal rat.

  American journal of nephrology 20120101

• β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats.

  Lipids in health and disease 20120101

• Rhabdomyolysis and acute renal failure following hard physical activity in a patient treated with rosuvastatin.

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20120101

• [Almanac 2011: Valvular heart disease. Review of select studies that have driven recent advances in clinical cardiology: in the care of the Editors' Network Task Force of the European Society of Cardiology].

  Giornale italiano di cardiologia (2006) 20120101

• The relation between serum lipids and lutein and zeaxanthin in the serum and retina: results from cross-sectional, case-control and case study designs.

  Lipids in health and disease 20120101

• Effects of rosuvastatin and atorvastatin on renal function: meta-analysis.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Effects of some anti-diabetic and cardioprotective agents on proliferation and apoptosis of human coronary artery endothelial cells.

  Cardiovascular diabetology 20120101

• Underrepresentation of elderly people in randomised controlled trials. The example of trials of 4 widely prescribed drugs.

  PloS one 20120101

• The effect of rosuvastatin in a murine model of influenza A infection.

  PloS one 20120101

• Rosuvastatin and the JUPITER trial: critical appraisal of a lifeless planet in the galaxy of primary prevention.

  International journal of occupational and environmental health 20120101

• Antibacterial activity of statins: a comparative study of atorvastatin, simvastatin, and rosuvastatin.

  Annals of clinical microbiology and antimicrobials 20120101

• Use of once-weekly statin in combination with ezetimibe in a patient with mitochondrial disease.

  BMJ case reports 20120101

• Rosuvastatin-induced pemphigoid.

  BMJ case reports 20120101

• Effect of rosuvastatin on ROCK activity, endothelial function, and inflammation in Asian patients with atherosclerosis.

  Internal medicine (Tokyo, Japan) 20120101

• LDL-induced impairment of human vascular smooth muscle cells repair function is reversed by HMG-CoA reductase inhibition.

  PloS one 20120101

• Adverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman.

  BMJ case reports 20120101

• [The Saturn study].

  Giornale italiano di cardiologia (2006) 20120101

• Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease.

  PloS one 20120101

• The high-dose rosuvastatin once weekly study (the HD-ROWS).

  Journal of clinical lipidology 20120101

• [Atorvastatin or rosuvastatin? Select from the perspective of evidence-based medicine].

  Kardiologiia 20120101

• A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class.

  PloS one 20120101

• [Case of purpura nephritis accompanied by idiopathic cholesterol embolism].

  Nihon Jinzo Gakkai shi 20120101

• [How to prolong life of patients at high cardiovascular risk. Features of rosuvastatin].

  Kardiologiia 20120101

• Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL.

  European journal of pharmacology 20111230

• [Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): -- the PATROL trial].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20111210

• [Symptomatic coronary heart disease. Impressive plaque reduction with high dose statins].

  MMW Fortschritte der Medizin 20111208

• Statins for primary prevention of venous thromboembolism.

  The Cochrane database of systematic reviews 20111207

• The effects of rosuvastatin alone or in combination with fenofibrate or omega 3 fatty acids on inflammation and oxidative stress in patients with mixed dyslipidemia.

  Expert opinion on pharmacotherapy 20111201

• The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats.

  European journal of drug metabolism and pharmacokinetics 20111201

• Effect of 2-year treatment with low-dose rosuvastatin on intima-media thickness in hypercholesterolemic subjects with asymptomatic carotid artery disease.

  Expert opinion on pharmacotherapy 20111201

• Effect of two intensive statin regimens on progression of coronary disease.

  The New England journal of medicine 20111201

• [Effects of different statins, ezetimibe/simvastatin combination on hsCRP levels in unstable angina pectoris and non-ST elevation myocardial infarction patients: a randomized trial].

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• [Achievement of therapeutic target in subjects on statin treatment in clinical practice. Results of the STAR (Statins Target Assessment in Real practice) study].

  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20111201

• Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial.

  JAMA 20111116

• Simultaneous determination of timolol maleate, rosuvastatin calcium and diclofenac sodium in pharmaceuticals and physiological fluids using HPLC-UV.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115

• Rosuvastatin does not affect human apolipoprotein A-I expression in genetically modified mice: a clue to the disputed effect of statins on HDL.

  British journal of pharmacology 20111101

• [Fibrillary nonamyloid glomerulonephritis: a rare etiology of nephrotic syndrome].

  Nephrologie & therapeutique 20111101

• Differential effect of statins on diabetic nephropathy in db/db mice.

  International journal of molecular medicine 20111101

• Effects of rosuvastatin on subclinical atherosclerosis and arterial stiffness in rheumatoid arthritis: a randomized controlled pilot trial.

  Scandinavian journal of rheumatology 20111101

• The human primary hepatocyte transcriptome reveals novel insights into atorvastatin and rosuvastatin action.

  Pharmacogenetics and genomics 20111101

• Algorithms to measure carotid intima-media thickness in trials: a comparison of reproducibility, rate of progression and treatment effect.

  Journal of hypertension 20111101

• Comparison of the effects of simvastatin vs. rosuvastatin vs. simvastatin/ezetimibe on parameters of insulin resistance.

  International journal of clinical practice 20111101

• Drug safety evaluation of rosuvastatin.

  Expert opinion on drug safety 20111101

• Apolipoprotein B100 is a better treatment target than calculated LDL and non-HDL cholesterol in statin-treated patients.

  Annals of clinical biochemistry 20111101

• Clinical experience with rosuvastatin in the management of hyperlipidemia and the reduction of cardiovascular risk.

  Expert review of cardiovascular therapy 20111101

• [COSMOS (coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects) trial].

  Nihon rinsho. Japanese journal of clinical medicine 20111101

• Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3.

  The Journal of organic chemistry 20111021

• Potential phototoxicity of rosuvastatin mediated by its dihydrophenanthrene-like photoproduct.

  Chemical research in toxicology 20111017

• Effect of rosuvastatin on hemoglobin levels in patients with anemia and low-grade inflammation: a post hoc analysis of the JUPITER trial.

  Journal of clinical pharmacology 20111001

• The JUPITER trial: myth or reality?

  Current atherosclerosis reports 20111001

• Lipid-altering efficacy of switching to ezetimibe/simvastatin 10/20 mg versus rosuvastatin 10 mg in high-risk patients with and without metabolic syndrome.

  Diabetes & vascular disease research 20111001

• Renal toxicity of lisinopril and rosuvastatin, alone and in combination, in Wistar rats.

  International journal of toxicology 20111001

• Angiotensin-II and rosuvastatin influence matrix remodeling in human mesangial cells via metalloproteinase modulation.

  Journal of hypertension 20111001

• [Rosuvastatin improves myocardial function and arteriosclerosis plaque in patients with ST-segment elevation after acute myocardial infarction and percutaneous coronary intervention].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111001

• I am a 60-year-old woman with CAD. My LDL is 64 and my HDL is 72 on Zocor, but my doctor thinks Crestor may be better for me. He says it is more potent and could reduce my numbers even more. I would have to pay for this drug out-of-pocket. Do you think the additional cost would be worth it?

  Heart advisor 20111001

• Rosuvastatin improves endothelial function in db/db mice: role of angiotensin II type 1 receptors and oxidative stress.

  British journal of pharmacology 20110901

• Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders.

  Pharmacological research 20110901

• Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism.

  European journal of pharmacology 20110901

• Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20110901

• Rationale and design of STOP DVT study: rosuvastatin for the prevention of deep vein thrombosis in patients undergoing total knee replacement arthroplasty--a prospective randomized open-label controlled trial.

  Contemporary clinical trials 20110901

• Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study.

  Lancet (London, England) 20110820

• Safety and efficacy of ezetimibe added on to rosuvastatin 5 or 10 mg versus up-titration of rosuvastatin in patients with hypercholesterolemia (the ACTE Study).

  The American journal of cardiology 20110815

• Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers.

  British journal of clinical pharmacology 20110801

• Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro.

  Journal of thrombosis and haemostasis : JTH 20110801

• Dose-dependent effect of rosuvastatin in the regulation of metalloproteinase expression.

  Annals of vascular surgery 20110801

• Radiation recall 5 years after whole-breast irradiation for early-stage breast cancer secondary to initiation of rosuvastatin and amlodipine.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110801

• Rosuvastatin beneficially alters the glomerular structure of kidneys from spontaneously hypertensive rats (SHRs).

  Journal of molecular histology 20110801

• pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.

  Molecular pharmaceutics 20110801

• Therapy and clinical trials: aggressive statin therapy versus combined and emerging approaches.

  Current opinion in lipidology 20110801

• HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

  Atherosclerosis 20110801

• Rosuvastatin blocks advanced glycation end products-elicited reduction of macrophage cholesterol efflux by suppressing NADPH oxidase activity via inhibition of geranylgeranylation of Rac-1.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110801

• A tale of three labels: translating the JUPITER trial data into regulatory claims.

  Clinical trials (London, England) 20110801

• A tale of five opinions (at least).

  Clinical trials (London, England) 20110801

• Regulatory divergence.

  Clinical trials (London, England) 20110801

• Translating study results to labeling.

  Clinical trials (London, England) 20110801

• Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide-deficient rats.

  Clinics (Sao Paulo, Brazil) 20110801

• [Impact of rosuvastatin on atherosclerosis lesions in apolipoprotein E knockout mice].

  Zhonghua xin xue guan bing za zhi 20110801

• Anti-apoptotic potential of rosuvastatin pretreatment in murine model of cardiomyopathy.

  International journal of cardiology 20110715

• Effect of lipid-lowering treatment on natural history of heterozygous familial hypercholesterolemia in past three decades.

  The American journal of cardiology 20110715

• Determination of chamaechromone in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study.

  Journal of pharmaceutical and biomedical analysis 20110715

• Effects of rosuvastatin on progression of stenosis in adult patients with congenital aortic stenosis (PROCAS Trial).

  The American journal of cardiology 20110715

• Beneficial effects of rosuvastatin on aortic adverse remodeling in nitric oxide-deficient rats.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110701

• Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease.

  Atherosclerosis 20110701

• The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes.

  Xenobiotica; the fate of foreign compounds in biological systems 20110701

• Rosuvastatin induces apoptosis in cultured human papillary thyroid cancer cells.

  The Journal of endocrinology 20110701

• Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms.

  Atherosclerosis 20110701

• Rosuvastatin attenuates the elevation in blood pressure induced by overexpression of human C-reactive protein.

  Hypertension research : official journal of the Japanese Society of Hypertension 20110701

• Rosuvastatin in diabetic hemodialysis patients.

  Journal of the American Society of Nephrology : JASN 20110701

• CRP induces hypertension in animal models: homo sapiens says no.

  Hypertension research : official journal of the Japanese Society of Hypertension 20110701

• Sunrise of statins after AURORA and 4D?

  Journal of the American Society of Nephrology : JASN 20110701

• Rosuvastatin, a new generation 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces ischemia/reperfusion-induced spinal cord tissue injury in rats.

  Annals of vascular surgery 20110701

• Race, ethnicity, and the efficacy of rosuvastatin in primary prevention: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.

  American heart journal 20110701

• [Pharmaco-economic optimization of cholesterol-lowering treatment with statins].

  Medicina clinica 20110625

• What else does the JUPITER trial add regarding C-reactive protein and cardiovascular disease?

  International journal of cardiology 20110616

• Impact of statins on glucose metabolism--a matter of debate.

  The American journal of cardiology 20110615

• Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.

  Fundamental & clinical pharmacology 20110601

• Effects of rosuvastatin on vascular biomarkers and carotid atherosclerosis in lupus: a randomized, double-blind, placebo-controlled trial.

  Arthritis care & research 20110601

• High doses of rosuvastatin are superior to low doses of rosuvastatin plus fenofibrate or n-3 fatty acids in mixed dyslipidemia.

  Lipids 20110601

• Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations.

  Xenobiotica; the fate of foreign compounds in biological systems 20110601

• Switching from statin monotherapy to ezetimibe/simvastatin or rosuvastatin modifies the relationships between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients at high risk of coronary disease.

  Clinical biochemistry 20110601

• Combining rosuvastatin with sartans of different peroxisome proliferator-activated receptor-γ activating capacity is not associated with different changes in low-density lipoprotein subfractions and plasma lipoprotein-associated phospholipase A₂.

  Metabolic syndrome and related disorders 20110601

• Impact of statins on progression of atherosclerosis: rationale and design of SATURN (Study of Coronary Atheroma by InTravascular Ultrasound: effect of Rosuvastatin versus AtorvastatiN).

  Current medical research and opinion 20110601

• Association between obesity, high-sensitivity C-reactive protein ≥2 mg/L, and subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study of Atherosclerosis.

  Arteriosclerosis, thrombosis, and vascular biology 20110601

• Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention.

  Circulation. Cardiovascular genetics 20110601

• Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study.

  International journal of clinical practice 20110601

• The effects of atorvastatin and rosuvastatin on oxidative stress in diabetic patients.

  European journal of internal medicine 20110601

• High-sensitivity C-reactive protein, obesity, and subclinical atherosclerosis: implications of JUPITER from the MESA study.

  Arteriosclerosis, thrombosis, and vascular biology 20110601

• Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis.

  American heart journal 20110601

• Longitudinal assessment of estimated glomerular filtration rate in apparently healthy adults: a post hoc analysis from the JUPITER study (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin).

  Clinical therapeutics 20110601

• [Effect of OATP1B1 521T --> C heterogenesis on pharmacokinetic characterstics of rosuvastatin in Chinese volunteers].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110601

• Fish odour syndrome.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20110517

• The editor's roundtable: JUPITER follow-up.

  The American journal of cardiology 20110515

• Open-label, ascending dose, prospective cohort study evaluating the antiviral efficacy of Rosuvastatin therapy in serum and lipid fractions in patients with chronic hepatitis C.

  Journal of viral hepatitis 20110501

• Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.

  Bioorganic & medicinal chemistry letters 20110501

• No effect of rosuvastatin in the zoledronate-induced acute-phase response.

  Calcified tissue international 20110501

• Statins alleviate experimental nerve injury-induced neuropathic pain.

  Pain 20110501

• Evaluating optimal lipid levels in patients with mixed dyslipidemia following short- and long-term treatment with fenofibric acid and statin combination therapy: a post hoc analysis.

  Current medical research and opinion 20110501

• Rosuvastatin prevents myocardial necrosis in an experimental model of acute myocardial infarction.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110501

• The methyl ester of rosuvastatin elicited an endothelium-independent and 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent relaxant effect in rat aorta.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110501

• Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol <50 mg/dl with rosuvastatin. The JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin).

  Journal of the American College of Cardiology 20110419

• Low coenzyme Q₁₀ levels and the outcome of statin treatment in heart failure.

  Journal of the American College of Cardiology 20110405

• Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9.

  Journal of lipid research 20110401

• The role of C-reactive protein as a risk predictor of coronary atherosclerosis: implications from the JUPITER trial.

  Current atherosclerosis reports 20110401

• Different effects of rosuvastatin and simvastatin on myocardial high-energy phosphate metabolism.

  International journal of cardiology 20110401

• Statins should be used with greater caution in patients undergoing thyroid hormone withdrawal for radioactive iodine treatment.

  Thyroid : official journal of the American Thyroid Association 20110401

• Rosuvastatin and primary cardiovascular prevention. Continue to use pravastatin or simvastatin.

  Prescrire international 20110401

• Statin treatment for primary prevention of vascular disease: whom to treat? Cost-effectiveness analysis.

  BMJ (Clinical research ed.) 20110330

• Simultaneous determination of rosuvastatin and atorvastatin in human serum using RP-HPLC/UV detection: method development, validation and optimization of various experimental parameters.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110315

• Rosuvastatin lowers coenzyme Q10 levels, but not mitochondrial adenosine triphosphate synthesis, in children with familial hypercholesterolemia.

  The Journal of pediatrics 20110301

• Rosuvastatin and thapsigargin modulate γ-secretase gene expression and APP processing in a human neuroglioma model.

  Journal of molecular neuroscience : MN 20110301

• Differential metabolic effects of distinct statins.

  Atherosclerosis 20110301

• Optimal statin type and dosage for vascular patients.

  Journal of vascular surgery 20110301

• Osteoprotegerin predicts progression of chronic heart failure: results from CORONA.

  Circulation. Heart failure 20110301

• Genetics of the coenzyme Q10 pathway and rosuvastatin-induced muscle effects.

  The Journal of pediatrics 20110301

• Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity.

  Pharmacogenetics and genomics 20110301

• Severe rhabdomyolysis due to rosuvastatin in a liver transplant subject with human immunodeficiency virus and immunosuppressive therapy-related dyslipidemia.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20110301

• [Effects of rosuvastatin on monocrotaline-induced pulmonary artery hypertension in rats].

  Zhonghua xin xue guan bing za zhi 20110301

• Low-density lipoprotein cholesterol goal attainment among Malaysian dyslipidemic patients.

  The Southeast Asian journal of tropical medicine and public health 20110301

• The cost-effectiveness of C-reactive protein testing and rosuvastatin treatment for patients with normal cholesterol levels.

  Journal of the American College of Cardiology 20110215

• The cost-effectiveness of rosuvastatin therapy JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin).

  Journal of the American College of Cardiology 20110215

• Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE study.

  International journal of cardiology 20110203

• Insulin resistance due to statin therapy: a potential contributor to the negation of statin-induced beneficial effects on cardiac remodelling in heart failure?

  International journal of cardiology 20110203

• Outcomes of high dose statin loading therapy.

  International journal of cardiology 20110203

• Small leucine-rich proteoglycans in atherosclerotic lesions: novel targets of chronic statin treatment?

  Journal of cellular and molecular medicine 20110201

• Rosuvastatin induces apoptosis in CD4(+)CD28 (null) T cells in patients with acute coronary syndromes.

  Clinical research in cardiology : official journal of the German Cardiac Society 20110201

• Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.

  Drug metabolism and disposition: the biological fate of chemicals 20110201

• Public health impact of statin prescribing strategies based on JUPITER.

  Preventive medicine 20110201

• Achievement of lipid targets with the combination of rosuvastatin and fenofibric Acid in patients with type 2 diabetes mellitus.

  Cardiovascular drugs and therapy 20110201

• Comparative Effectiveness and Toxicity of Statins Among HIV-Infected Patients.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110201

• A crossover study of rosuvastatin and pitavastatin in patients with type 2 diabetes.

  Advances in therapy 20110201

• Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammation.

  The American journal of cardiology 20110201

• Alternate day rosuvastatin, an underutilized option in statin intolerant hyperlipidemic patients: a case report and literature review.

  Tennessee medicine : journal of the Tennessee Medical Association 20110201

• Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides.

  Cardiovascular drugs and therapy 20110201

• eNOS/Hsp70 interaction on rosuvastatin cytoprotective effect in neonatal obstructive nephropathy.

  European journal of pharmacology 20110115

• High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study.

  International journal of cardiology 20110107

• 12-month follow-up results of high dose rosuvastatin loading before percutaneous coronary intervention in patients with acute coronary syndrome.

  International journal of cardiology 20110107

• Unending debate: statin dilemma in the management of heart failure.

  International journal of cardiology 20110107

• Pre-procedural use of statins for all patients undergoing percutaneous coronary intervention.

  International journal of cardiology 20110107

• Rosuvastatin restored adrenergic and nitrergic function in mesenteric arteries from obese rats.

  British journal of pharmacology 20110101

• Characterization of digoxin uptake in sandwich-cultured human hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors.

  Xenobiotica; the fate of foreign compounds in biological systems 20110101

• Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.

  Drug metabolism and disposition: the biological fate of chemicals 20110101

• Involvement of the p38 pathway in the differential induction of heme oxygenase-1 by statins in Neuro-2A cells exposed to lipopolysaccharide.

  Drug and chemical toxicology 20110101

• Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥ 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities.

  European heart journal 20110101

• Effects of atorvastatin and rosuvastatin on thromboxane-dependent platelet activation and oxidative stress in hypercholesterolemia.

  Atherosclerosis 20110101

• Suppression of Idol expression is an additional mechanism underlying statin-induced up-regulation of hepatic LDL receptor expression.

  International journal of molecular medicine 20110101

• The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins.

  Expert opinion on drug metabolism & toxicology 20110101

• Aleglitazar, a balanced PPARα/γ agonist, has no clinically relevant pharmacokinetic interaction with high-dose atorvastatin or rosuvastatin.

  Expert opinion on investigational drugs 20110101

• Paradoxical decrease in HDL-cholesterol and apolipoprotein A1 with simvastatin and atorvastatin in a patient with type 2 diabetes.

  Annals of clinical biochemistry 20110101

• Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: the impact of inflammatory process and oxidative stress.

  Atherosclerosis 20110101

• The risks of a new hypothesis: why did JUPITER patients have almost twice the predicted event rate of reduction?

  Journal of cardiovascular medicine (Hagerstown, Md.) 20110101

• Race differences: modeling the pharmacodynamics of rosuvastatin in Western and Asian hypercholesterolemia patients.

  Acta pharmacologica Sinica 20110101

• Comparison of effects of rosuvastatin and atorvastatin on plaque regression in Korean patients with untreated intermediate coronary stenosis.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Early intervention with rosuvastatin decreases the lipid components of the plaque in acute coronary syndrome: analysis using integrated backscatter IVUS (ELAN study).

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study.

  Cardiovascular ultrasound 20110101

• A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial.

  Trials 20110101

• Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderly.

  Clinical interventions in aging 20110101

• Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): the PATROL trial.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• [Possible rosuvastatin-induced fatal rhabdomyolysis].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101

• Strong statins as the major players for dyslipidemia in high-risk patients: are they all the same or not?

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Rhabdomyolysis in an HIV-infected patient with impaired renal function concomitantly treated with rosuvastatin and lopinavir/ritonavir.

  Antiviral therapy 20110101

• Primary prevention with statins is more cost-effective.

  Cardiovascular journal of Africa 20110101

• Clinical use and effectiveness of lipid lowering therapies in diabetes mellitus--an observational study from the Swedish National Diabetes Register.

  PloS one 20110101

• The use of plaque score measurements to assess changes in atherosclerotic plaque burden induced by lipid-lowering therapy over time: the METEOR study.

  Journal of atherosclerosis and thrombosis 20110101

• Efficacy analysis of the lipid-lowering and renoprotective effects of rosuvastatin in patients with chronic kidney disease.

  Endocrine journal 20110101

• Rosuvastatin therapy does not affect serum MMP-13 or TIMP-1 levels in hypercholesterolemic patients.

  Texas Heart Institute journal 20110101

• Effect of atorvastatin vs. rosuvastatin on cardiac sympathetic nerve activity in non-diabetic patients with dilated cardiomyopathy.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Efficacy and tolerability of once-weekly rosuvastatin in patients with previous statin intolerance.

  Journal of clinical lipidology 20110101

• Concordance between plasma apolipoprotein B levels and cholesterol indices among patients receiving statins and nonstatin treatment: Post-hoc analyses from the U.K. InPractice study.

  Journal of clinical lipidology 20110101

• Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey.

  Drug design, development and therapy 20110101

• The role of soluble fiber intake in patients under highly effective lipid-lowering therapy.

  Nutrition journal 20110101

• Clinical usefulness of additional treatment with ezetimibe in patients with coronary artery disease on statin therapy. - From the viewpoint of cholesterol metabolism.-.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Intensive lipid-lowering therapy with rosuvastatin stabilizes lipid-rich coronary plaques. -Evaluation using dual-source computed tomography.-.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.

  BMC systems biology 20110101

• Comparative efficacy of ezetimibe/simvastatin, rosuvastatin, and atorvastatin in uncontrolled hyperlipidemia patients.

  The American journal of managed care 20110101

• Low-dose rosuvastatin improves arterial stiffness in high-risk Japanese patients with dyslipdemia in a primary prevention group.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• No evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis.

  Journal of biomedicine & biotechnology 20110101

• Effects of lipid-lowering therapy with rosuvastatin on kidney function and oxidative stress in patients with diabetic nephropathy.

  Journal of atherosclerosis and thrombosis 20110101

• Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats.

  Lipids in health and disease 20110101

• Estimating treatment effects for individual patients based on the results of randomised clinical trials.

  BMJ (Clinical research ed.) 20110101

• Effects of combination therapy with rosuvastatin and fenofibric acid in patients with mixed dyslipidemia and high-sensitivity C-reactive protein (≥ 2 mg/L). cmb@bcm.tmc.edu.

  Journal of clinical lipidology 20110101

• Effect of rosuvastatin treatment on cholesterol efflux from human macrophages.

  Neuro endocrinology letters 20110101

• Extreme all-cause mortality in JUPITER requires reexamination of vital records.

  Cardiology 20110101

• Is chronic severe anemia an independent predictor of poor outcomes?

  Cardiology 20110101

• [Statins in primary prophylaxis of cardiovascular diseases].

  Terapevticheskii arkhiv 20110101

• Effects of rosuvastatin versus atorvastatin on rho-associated coiled-coil containing protein kinase activity and endothelial function in patients with atherosclerosis.

  The Journal of international medical research 20110101

• Statin resistant dyslipidemia in a patient treated with amiodarone.

  BMJ case reports 20110101

• Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents.

  International journal of cancer 20101215

• Trials by independent expert bodies.

  Archives of internal medicine 20101213

• Letter by Wells and Eisenberg regarding article, 'Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials'.

  Circulation 20101207

• Letter by Vos et al regarding article, 'Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials'.

  Circulation 20101207

• Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure.

  International journal of cardiology 20101203

• Rosuvastatin and vitamin D: might there be hypovitaminosis D on JUPITER?

  International journal of cardiology 20101203

• Immunomodulatory effects of rosuvastatin on hepatic ischemia/reperfusion induced injury.

  Immunopharmacology and immunotoxicology 20101201

• Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population.

  Metabolism: clinical and experimental 20101201

• Use of multiple international healthcare databases for the detection of rare drug-associated outcomes: a pharmacoepidemiological programme comparing rosuvastatin with other marketed statins.

  Pharmacoepidemiology and drug safety 20101201

• Effects of n-3 polyunsaturated fatty acids and of rosuvastatin on left ventricular function in chronic heart failure: a substudy of GISSI-HF trial.

  European journal of heart failure 20101201

• Efficacy and safety of rosuvastatin 5 mg in combination with fenofibric acid 135 mg in patients with mixed dyslipidemia - a phase 3 study.

  Cardiovascular drugs and therapy 20101201

• Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily).

  The American journal of cardiology 20101201

• Characteristics and drug utilization patterns of new users of rosuvastatin and other statins in four countries.

  Minerva cardioangiologica 20101201

• WT-1 mRNA expression is modulated by nitric oxide availability and Hsp70 interaction after neonatal unilateral ureteral obstruction.

  Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20101201

• HDL cholesterol and residual risk of first cardiovascular events.

  Lancet (London, England) 20101120

• Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD.

  Biochemical and biophysical research communications 20101112

• No effect of rosuvastatin on left ventricular hypertrophy in patients with hypertension: a prospective randomised open-label study with blinded endpoint assessment.

  International journal of cardiology 20101105

• Comparison of rosuvastatin and atorvastatin on clopidogrel response and lipidic and inflammatory parameters after coronary stenting for acute coronary syndrome: the prospective, randomized OSCAR study (optimal statin therapy with clopidogrel after coronary revascularisation).

  Thrombosis research 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• [On the current debate on lowering LDL cholesterol with ezetimibe].

  Deutsche medizinische Wochenschrift (1946) 20101101

• Impact of baseline plaque components on plaque progression in nonintervened coronary segments in patients with angina pectoris on rosuvastatin 10 mg/day.

  The American journal of cardiology 20101101

• The JUPITER Trial: responding to the critics.

  The American journal of cardiology 20101101

• Statin therapy in primary prevention: new insights regarding women and the elderly.

  The American journal of cardiology 20101101

• Endothelial progenitor cells in patients with acute cerebrovascular ischemia.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20101101

• Prevalence of dyslipidemia in statin-treated patients in Canada: results of the DYSlipidemia International Study (DYSIS).

  The Canadian journal of cardiology 20101101

• Serum levels of C-reactive protein in patients with stable coronary artery disease: JUPITER in perspective.

  International journal of cardiology 20101029

• High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis.

  Circulation 20101026

• Is diabetes the cost to pay for a greater cardiovascular prevention?

  International journal of cardiology 20101008

• Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure).

  Journal of the American College of Cardiology 20101005

• Coenzyme Q10 and statins in heart failure: the dog that didn't bark.

  Journal of the American College of Cardiology 20101005

• Coadministration of dalcetrapib with pravastatin, rosuvastatin, or simvastatin: no clinically relevant drug-drug interactions.

  Journal of clinical pharmacology 20101001

• Upregulation of ecto-5'-nucleotidase by rosuvastatin increases the vasodilator response to ischemia.

  Hypertension (Dallas, Tex. : 1979) 20101001

• Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.

  Pharmacogenetics and genomics 20101001

• Change in serum lipids after acute coronary syndromes: secondary analysis of SPACE ROCKET study data and a comparative literature review.

  Clinical chemistry 20101001

• Effect of increasing doses of Rosuvastatin and Atorvastatin on apolipoproteins, enzymes and lipid transfer proteins involved in lipoprotein metabolism and inflammatory parameters.

  Current medical research and opinion 20101001

• Lactone pathway to statins utilizing the Wittig reaction. The synthesis of rosuvastatin.

  The Journal of organic chemistry 20101001

• Rhabdomyolysis induced by rosuvastatin and sildenafil.

  Southern medical journal 20101001

• Cost-effectiveness of statin therapy for vascular event prevention in adults with elevated C-reactive protein: implications of JUPITER.

  Current medical research and opinion 20101001

• Case report. Hyperlipoproteinaemia(a): which is the optimal therapy? A case report.

  Journal of clinical pharmacy and therapeutics 20101001

• Ancestry as a determinant of mean population C-reactive protein values: implications for cardiovascular risk prediction.

  Circulation. Cardiovascular genetics 20101001

• Combination rosuvastatin plus fenofibric acid in a cohort of patients 65 years or older with mixed dyslipidemia: subanalysis of two randomized, controlled studies.

  Clinical cardiology 20101001

• Heterozygous familial hypercholesterolemia case study.

  Journal of the American Academy of Nurse Practitioners 20101001

• Effects of statins on vascular endothelial function in hypercholesterolemic patients with type 2 diabetes mellitus: fluvastatin vs. rosuvastatin.

  International journal of cardiology 20100924

• Interpreting and evaluating the details of the JUPITER study.

  American family physician 20100915

• Effect of a single gemfibrozil dose on the pharmacokinetics of rosuvastatin in bile and plasma in healthy volunteers.

  Journal of clinical pharmacology 20100901

• Rosuvastatin-induced gynaecomastia.

  Clinical endocrinology 20100901

• The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse.

  American journal of physiology. Renal physiology 20100901

• Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction.

  European journal of heart failure 20100901

• Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer.

  European urology 20100901

• Impact of restricted reimbursement on the use of statins in Finland: a register-based study.

  Medical care 20100901

• Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for 'intermediate risk'.

  Circulation. Cardiovascular quality and outcomes 20100901

• Relationship between bicuspid aortic valve morphology and aortic wall degeneration: further evidence is emerging.

  Echocardiography (Mount Kisco, N.Y.) 20100901

• Statin loading before percutaneous coronary intervention: proposed mechanisms and applications.

  Future cardiology 20100901

• [Rosuvastatin enhances the protective effects of ischemic postconditioning on myocardial ischaemia-reperfusion injury in type 2 diabetic rat].

  Zhonghua xin xue guan bing za zhi 20100901

• [Role of rosuvastatin in current lipid-lowering therapy].

  Orvosi hetilap 20100829

• C-reactive protein lowering with rosuvastatin in the METEOR study.

  Journal of internal medicine 20100801

• Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models.

  Inflammopharmacology 20100801

• The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo.

  Xenobiotica; the fate of foreign compounds in biological systems 20100801

• Improved cardiac performance by rosuvastatin is associated with attenuations in both myocardial tumor necrosis factor-alpha and p38 MAP kinase activity in rats after myocardial infarction.

  The American journal of the medical sciences 20100801

• Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trial.

  American heart journal 20100801

• Statin therapy for elevated hsCRP: what are the public health implications?

  The American journal of managed care 20100801

• Statin therapy for elevated hsCRP: more evidence is needed.

  The American journal of managed care 20100801

• Was the FDA misled by JUPITER?

  The Journal of the American Osteopathic Association 20100801

• Cost-effectiveness of rosuvastatin for primary prevention of cardiovascular events according to Framingham Risk Score in patients with elevated C-reactive protein.

  The Journal of the American Osteopathic Association 20100801

• HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial.

  Lancet (London, England) 20100731

• Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions.

  Brain research 20100730

• Homozygous familial hypercholesterolaemia and treatment by LDL apheresis.

  The New Zealand medical journal 20100730

• Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER).

  The American journal of cardiology 20100715

• Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells.

  Cell biology international 20100701

• Terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, increases survival in stroke-prone rats by preventing systemic inflammation and endothelial dysfunction: comparison with aspirin and rosuvastatin.

  The Journal of pharmacology and experimental therapeutics 20100701

• Expression of the hepatic Niemann-Pick C1 like 1 protein gene is sensitive to rosuvastatin treatment of primary human hepatocytes.

  Pharmacogenetics and genomics 20100701

• Incremental cholesterol reduction with ezetimibe/simvastatin, atorvastatin and rosuvastatin in UK General Practice (IN-PRACTICE): randomised controlled trial of achievement of Joint British Societies (JBS-2) cholesterol targets.

  International journal of clinical practice 20100701

• Imperfect pharmacovigilance.

  Southern medical journal 20100701

• Rosuvastatin-induced thrombocytopenia.

  Southern medical journal 20100701

• Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?

  Pharmacogenomics 20100701

• Cholesterol lowering, cardiovascular diseases, and the rosuvastatin-JUPITER controversy: a critical reappraisal.

  Archives of internal medicine 20100628

• Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering.

  International journal of cardiology 20100625

• JUPITER, rosuvastatin, and the European Medicines Agency.

  Lancet (London, England) 20100612

• Rosuvastatin protects tissue perfusion in the experimental testicular torsion model.

  International urology and nephrology 20100601

• Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters.

  Journal of lipid research 20100601

• Effects of atorvastatin 20 mg, rosuvastatin 10 mg, and atorvastatin/ezetimibe 5 mg/5 mg on lipoproteins and glucose metabolism.

  Journal of cardiovascular pharmacology and therapeutics 20100601

• Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study.

  Circulation. Cardiovascular genetics 20100601

• Glucose-regulated protein 78 and platelet deposition: effect of rosuvastatin.

  Arteriosclerosis, thrombosis, and vascular biology 20100601

• Acute renal failure with the combined use of rosuvastatin and fenofibrate.

  Renal failure 20100601

• Effects of three strong statins (atorvastatin, pitavastatin, and rosuvastatin) on serum uric acid levels in dyslipidemic patients.

  Nucleosides, nucleotides & nucleic acids 20100601

• [The AURORA study].

  Giornale italiano di cardiologia (2006) 20100601

• Highly stereoselective hydrogenations--as key-steps in the total synthesis of statins.

  Chirality 20100515

• Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study.

  Atherosclerosis 20100501

• Early vascular and metabolic effects of rosuvastatin compared with simvastatin in patients with type 2 diabetes.

  Atherosclerosis 20100501

• ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin.

  Clinical pharmacology and therapeutics 20100501

• Reversal of age-associated memory impairment by rosuvastatin in rats.

  Experimental gerontology 20100501

• Cost-effectiveness of rosuvastatin versus ezetimibe/simvastatin in managing dyslipidemic patients in Mexico.

  Current medical research and opinion 20100501

• By the way, doctor. I take a fiber supplement, but have heard that I shouldn't be taking it at the same times as medication. How far apart should I take fiber and medicines such as Plavix and Crestor?

  Harvard health letter 20100501

• Can intensive lipid-lowering therapy with statins ameliorate atherosclerosis in Japanese patients? Rationale and design of the JART study.

  Journal of atherosclerosis and thrombosis 20100430

• Summaries for patients. Rosuvastatin to prevent heart problems and stroke in persons 70 years or older.

  Annals of internal medicine 20100420

• Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial.

  Annals of internal medicine 20100420

• Statins for primary prevention in older adults: who is high risk, who is old, and what denotes primary prevention?

  Annals of internal medicine 20100420

• Rosuvastatin and cardiovascular continuum when time is important.

  Journal of the American College of Cardiology 20100413

• FDA approves a statin therapy for some: certain, asymptomatic individuals targeted.

  JAMA 20100407

• In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects.

  Acta biomaterialia 20100401

• Does baseline carotid intima-media thickness modify the effect of rosuvastatin when compared with placebo on carotid intima-media thickness progression? The METEOR study.

  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20100401

• Use of a combination of prednisolone and rosuvastatin for treatment of a pyogranuloma in a dog.

  Journal of the American Veterinary Medical Association 20100401

• Should we measure C-reactive protein on earth or just on JUPITER?

  Clinical cardiology 20100401

• Enhanced effect of losartan and rosuvastatin on neointima hyperplasia.

  Archives of pharmacal research 20100401

• Achieving treatment goals in low-risk, asymptomatic patients.

  The Journal of the American Osteopathic Association 20100401

• New analysis supports expanded use of statins in women.

  Harvard women's health watch 20100401

• Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating Rosuvastatin) trial.

  Journal of the American College of Cardiology 20100323

• Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia.

  Journal of the American College of Cardiology 20100316

• Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials.

  Circulation 20100309

• The numbers are in: statins for the primary prevention of cardiovascular disease in women.

  Circulation 20100309

• Rosuvastatin prevents conduit artery endothelial dysfunction induced by ischemia and reperfusion by a cyclooxygenase-2-dependent mechanism.

  Journal of the American College of Cardiology 20100309

• Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20100301

• Comparison of sequential rosuvastatin doses in hypercholesterolaemia: a meta-analysis of randomised controlled trials.

  Current medical research and opinion 20100301

• Signal detection of rosuvastatin compared to other statins: data-mining study using national health insurance claims database.

  Pharmacoepidemiology and drug safety 20100301

• Persistent regional diastolic dysfunction after myocardial ischemia and the effect of statin treatment: assessment with two-dimensional radial strain rate.

  Echocardiography (Mount Kisco, N.Y.) 20100301

• Comparative study of low doses of rosuvastatin and atorvastatin on lipid and glycemic control in patients with metabolic syndrome and hypercholesterolemia.

  The Korean journal of internal medicine 20100301

• Interpreting the JUPITER trial: statins can prevent VTE, but more study is needed.

  Cleveland Clinic journal of medicine 20100301

• The effects of rosuvastatin on the serum cortisol, serum lipid, and serum mevalonic acid levels in the healthy Indian male population.

  AAPS PharmSciTech 20100301

• [Effects of rosuvastatin on left ventricular cardiac function, arteriosclerotic plaque and high sensitive C-reactive protein in hypertensive patients with mild LDL-C elevation].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100301

• Effects of rosuvastatin combined with olmesartan, irbesartan, or telmisartan on indices of glucose metabolism in Greek adults with impaired fasting glucose, hypertension, and mixed hyperlipidemia: a 24-week, randomized, open-label, prospective study.

  Clinical therapeutics 20100301

• Pharmacokinetics of rosuvastatin in healthy Chinese volunteers living in China: a randomized, open-label, ascending single- and multiple-dose study.

  Clinical therapeutics 20100301

• Comparison of the efficacy of rosuvastatin versus atorvastatin in reducing apolipoprotein B/apolipoprotein A-1 ratio in patients with acute coronary syndrome: results of the CENTAURUS study.

  Archives of cardiovascular diseases 20100301

• Effects of rosuvastatin on coronary flow reserve and metabolic mismatch in patients with heart failure (from the CORONA Study).

  The American journal of cardiology 20100215

• Rosuvastatin inhibits norepinephrine-induced cardiac hypertrophy via suppression of Gh.

  European journal of pharmacology 20100210

• Human skeletal muscle drug transporters determine local exposure and toxicity of statins.

  Circulation research 20100205

• Association of Bicuspid aortic valve morphology and aortic root dimensions: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study.

  Echocardiography (Mount Kisco, N.Y.) 20100201

• Prescribing statins in aortic stenosis: little to lose, much to gain.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20100201

• Ammonium methacrylate units polymer content and their effect on acyclovir colloidal nanoparticles properties and bioavailability in human volunteers.

  Colloids and surfaces. B, Biointerfaces 20100201

• The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.

  The pharmacogenomics journal 20100201

• Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons.

  Neurochemistry international 20100201

• Measuring hsCRP--an important part of a comprehensive risk profile or a clinically redundant practice?

  PLoS medicine 20100201

• Prevention of peri-procedural myocardial injury using a single high loading dose of rosuvastatin.

  Cardiovascular drugs and therapy 20100201

• Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial.

  Circulation 20100119

• Public health. U.S. panel favors wider use of preventive drug treatment.

  Science (New York, N.Y.) 20100108

• Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER).

  Circulation 20100105

• Rosuvastatin versus pravastatin in dyslipidemic HIV-1-infected patients receiving protease inhibitors: a randomized trial.

  AIDS (London, England) 20100102

• Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.

  Drug metabolism and disposition: the biological fate of chemicals 20100101

• Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis.

  Diabetes research and clinical practice 20100101

• Year two assessment of fenofibric acid and moderate-dose statin combination: a phase 3, open-label, extension study.

  Clinical drug investigation 20100101

• An economic evaluation of rosuvastatin treatment in systolic heart failure: evidence from the CORONA trial.

  European journal of heart failure 20100101

• Earth to JUPITER: how a potent statin may actually be detrimental for lifestyle-associated diseases.

  Angiology 20100101

• HMG-CoA reductase inhibitor improves endothelial dysfunction in spontaneous hypertensive rats via down-regulation of caveolin-1 and activation of endothelial nitric oxide synthase.

  Journal of Korean medical science 20100101

• Meta-analysis of comparative efficacy of increasing dose of Atorvastatin versus Rosuvastatin versus Simvastatin on lowering levels of atherogenic lipids (from VOYAGER).

  The American journal of cardiology 20100101

• Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• One-year treatment with rosuvastatin reduces intima-media thickness in 45 hypercholesterolemic subjects with asymptomatic carotid artery disease.

  Pharmacology 20100101

• Efficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: results of a pooled subgroup analysis from three randomized, controlled, double-blind trials.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• Effect of rosuvastatin on cholestasis-induced hepatic injury in rat livers.

  Journal of biochemical and molecular toxicology 20100101

• [Non-ST-elevation acute coronary syndrome. Comparison of effects of atorvastatin and rosuvastatin on blood levels of lipids and markers of inflammation].

  Kardiologiia 20100101

• Efficacy and safety of ezetimibe for Japanese patients with dyslipidaemia: The ESSENTIAL Study.

  Clinical drug investigation 20100101

• Cardiovascular risk in uremic patients: darkness after AURORA.

  Renal failure 20100101

• Is Jupiter also a god of primary prevention?

  Texas Heart Institute journal 20100101

• The Post-JUPITER trial era and the cost of preventive medicine.

  Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20100101

• From CARDS to AURORA: one disease, two responses.

  Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20100101

• Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm.

  Biological & pharmaceutical bulletin 20100101

• Efficacy and safety of rosuvastatin and fenofibric acid combination therapy versus simvastatin monotherapy in patients with hypercholesterolemia and hypertriglyceridemia: a randomized, double-blind study.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• Cost effectiveness of rosuvastatin in patients at risk of cardiovascular disease based on findings from the JUPITER trial.

  Journal of medical economics 20100101

• The endothelial-protective effects of HMG-CoA reductase inhibition in the setting of ischemia and reperfusion injury.

  Clinical hemorheology and microcirculation 20100101

• Determination of rosuvastatin and ezetimibe in a combined tablet dosage form using high-performance column liquid chromatography and high-performance thin-layer chromatography.

  Journal of AOAC International 20100101

• Ezetimibe/simvastatin 10/20 mg versus rosuvastatin 10 mg in high-risk hypercholesterolemic patients stratified by prior statin treatment potency.

  Lipids in health and disease 20100101

• Rosuvastatin promotes osteoblast differentiation and regulates SLCO1A1 transporter gene expression in MC3T3-E1 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Rosuvastatin: a review of its use in the prevention of cardiovascular disease in apparently healthy women or men with normal LDL-C levels and elevated hsCRP levels.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• A case report of a diabetic woman with very low HDL cholesterol.

  Journal of clinical lipidology 20100101

• Complete Apo AI deficiency in an Iraqi Mandaean family: case studies and review of the literature.

  Journal of clinical lipidology 20100101

• Switching from high-efficacy lipid-lowering therapies to simvastatin and low-density lipoprotein cholesterol goal attainment in coronary heart disease/coronary heart disease-equivalent patients.

  Journal of clinical lipidology 20100101

• Rosuvastatin reduces neointima formation in a rat model of balloon injury.

  European journal of medical research 20100101

• Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective.

  Drug design, development and therapy 20100101

• Hepatic lipase deficiency in a Middle-Eastern-Arabic male.

  BMJ case reports 20100101

• Clinical efficacy of rosuvastatin in lipid management in Chinese patients in Hong Kong.

  Chinese medical journal 20091205

• Rosuvastatin attenuates Ang II--mediated cardiomyocyte hypertrophy via inhibition of LOX-1.

  Journal of cardiovascular pharmacology and therapeutics 20091201

• A randomized, controlled trial of simvastatin versus rosuvastatin in patients with acute myocardial infarction: the Secondary Prevention of Acute Coronary Events--Reduction of Cholesterol to Key European Targets Trial.

  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20091201

• Enterohepatic disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine and gemfibrozil.

  Drug metabolism and disposition: the biological fate of chemicals 20091201

• Effectiveness of rosuvastatin compared to other statins for the prevention of cardiovascular events-a cohort study in 395 039 patients from clinical practice.

  Pharmacoepidemiology and drug safety 20091201

• Rediscovering bile acid sequestrants.

  Diabetes, obesity & metabolism 20091201

• Effects of rosuvastatin on asymmetric dimethylarginine levels and early atrial fibrillation recurrence after electrical cardioversion.

  Pacing and clinical electrophysiology : PACE 20091201

• Usefulness of aggressive lipid-lowering therapy with rosuvastatin in hypercholesterolemic patients with concomitant type 2 diabetes.

  Endocrine 20091201

• Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic chronic heart failure.

  European journal of heart failure 20091201

• Effect of targeting mitogen-activated protein kinase on cardiac remodeling in rats.

  Journal of cardiovascular pharmacology and therapeutics 20091201

• Effectiveness of rosuvastatin in reducing LDL-C and target LDL-C goal attainment in real-world clinical practice.

  Current medical research and opinion 20091201

• Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysis.

  Circulation 20091201

• Low-density lipoprotein cholesterol reduction and goal achievement with ezetimibe/simvastatin versus atorvastatin or rosuvastatin in patients with diabetes, metabolic syndrome, or neither disease, stratified by National Cholesterol Education Program risk category.

  Metabolic syndrome and related disorders 20091201

• Another look at the results of the JUPITER trial.

  The American journal of cardiology 20091201

• Pharmacokinetics of rosuvastatin in patients with end-stage kidney disease undergoing peritoneal dialysis.

  Clinical nephrology 20091201

• Clinical trial update II: Jupiter trial, rosuvastatin has greater efficacy in elderly populations.

  European heart journal 20091201

• Efficacy of combination drug pulse therapy in maintaining lipid levels in patients intolerant of daily statin use.

  Journal of clinical hypertension (Greenwich, Conn.) 20091201

• [The JUPITER study: background and research hypotheses].

  Giornale italiano di cardiologia (2006) 20091201

• [The JUPITER study: critical review of final results].

  Giornale italiano di cardiologia (2006) 20091201

• [JUPITER, what now?].

  Giornale italiano di cardiologia (2006) 20091201

• The beneficial effect of high loading dose of rosuvastatin before percutaneous coronary intervention in patients with acute coronary syndrome.

  International journal of cardiology 20091112

• Plasma concentration of amino-terminal pro-brain natriuretic peptide in chronic heart failure: prediction of cardiovascular events and interaction with the effects of rosuvastatin: a report from CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure).

  Journal of the American College of Cardiology 20091110

• Can natriuretic peptides help identify heart failure patients for whom statins are beneficial?

  Journal of the American College of Cardiology 20091110

• Influence of statin treatment on platelet inhibition by clopidogrel - a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatment.

  Journal of internal medicine 20091101

• Comparison of incidences of cardiovascular events among new users of different statins: a retrospective observational cohort study.

  Current medical research and opinion 20091101

• Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS).

  Circulation journal : official journal of the Japanese Circulation Society 20091101

• Cosmic effect of rosuvastatin in COSMOS.

  Circulation journal : official journal of the Japanese Circulation Society 20091101

• Efficacy of aggressive lipid controlling therapy for preventing saphenous vein graft disease.

  The Annals of thoracic surgery 20091101

• [From lipid target values to the JUPITER study. Significance of achieving lipid levels specified by the guidelines and deficiencies in practice].

  Orvosi hetilap 20091101

• Occurrence and fate of rosuvastatin, rosuvastatin lactone, and atorvastatin in Canadian sewage and surface water samples.

  Chemosphere 20091101

• Rosuvastatin along the cardiovascular continuum: from JUPITER to AURORA.

  Expert review of cardiovascular therapy 20091101

• Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER).

  Circulation. Cardiovascular quality and outcomes 20091101

• Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat.

  Basic & clinical pharmacology & toxicology 20091001

• Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine.

  Journal of cardiovascular pharmacology 20091001

• Effects of rosuvastatin on atrial fibrillation occurrence: ancillary results of the GISSI-HF trial.

  European heart journal 20091001

• Effects of a 3-month course of rosuvastatin in patients with systemic lupus erythematosus.

  Annals of the rheumatic diseases 20091001

• Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet.

  The American journal of the medical sciences 20091001

• [The role of statins in the treatment of heart failure].

  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001

• [C-reactive protein and coronary heart disease: quo vadis?].

  MMW Fortschritte der Medizin 20091001

• Statins and angiogenesis: is it about connections?

  Biochemical and biophysical research communications 20090925

• [Sympathetic nerve in rat with pressure overload left ventricular hypertrophy].

  Zhonghua yi xue za zhi 20090915

• Effects of rosuvastatin on electronegative LDL as characterized by capillary isotachophoresis: the ROSARY Study.

  Journal of lipid research 20090901

• Induction of RISK by HMG-CoA reductase inhibition affords cardioprotection after myocardial infarction.

  Atherosclerosis 20090901

• Effect of rosuvastatin on cardiac remodeling, function, and progression to heart failure in hypertensive heart with established left ventricular hypertrophy.

  Hypertension (Dallas, Tex. : 1979) 20090901

• Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat.

  American journal of physiology. Heart and circulatory physiology 20090901

• Rosuvastatin treatment is associated with an increase in insulin resistance in hyperlipidaemic patients with impaired fasting glucose.

  International journal of clinical practice 20090901

• Primary prevention of vascular events in patients with high levels of C-reactive protein: the JUPITER study.

  Expert review of cardiovascular therapy 20090901

• [To treat or not to treat with statins patients with chronic heart failure?].

  Vnitrni lekarstvi 20090901

• Most would fail to benefit from JUPITER Intervention.

  Journal of the American College of Cardiology 20090818

• Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients.

  Journal of thrombosis and thrombolysis 20090801

• Insights into atherosclerosis from invasive and non-invasive imaging studies: Should we treat subclinical atherosclerosis?

  Atherosclerosis 20090801

• The Jupiter study, CRP screening, and aggressive statin therapy-implications for the primary prevention of cardiovascular disease.

  Therapeutic advances in cardiovascular disease 20090801

• ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

  Clinical pharmacology and therapeutics 20090801

• Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?

  Cardiovascular drugs and therapy 20090801

• Severe HIV-associated hypertriglyceridaemia treated with rosuvastatin plus omega-3 fatty acids.

  International journal of STD & AIDS 20090801

• Alternate day dosing of rosuvastatin: potential usefulness in statin-intolerant patients.

  The Canadian journal of cardiology 20090801

• No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

  British journal of clinical pharmacology 20090801

• Effects of rosuvastatin on low-density lipoprotein cholesterol and plasma lipids in Asian patients with hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20090801

• Rosuvastatin for cardiovascular prevention: too many uncertainties.

  Prescrire international 20090801

• [Significance of determination of lipid-oxidizing catalytic antibodies in patients with ischemic heart diseases].

  Klinicheskaia laboratornaia diagnostika 20090801

• Rosuvastatin, C-reactive protein, LDL cholesterol, and the JUPITER trial.

  Lancet (London, England) 20090704

• Rosuvastatin, C-reactive protein, LDL cholesterol, and the JUPITER trial.

  Lancet (London, England) 20090704

• Rosuvastatin, C-reactive protein, LDL cholesterol, and the JUPITER trial.

  Lancet (London, England) 20090704

• Rosuvastatin, C-reactive protein, LDL cholesterol, and the JUPITER trial.

  Lancet (London, England) 20090704

• Rosuvastatin, C-reactive protein, LDL cholesterol, and the JUPITER trial.

  Lancet (London, England) 20090704

• Rosuvastatin, C-reactive protein, LDL cholesterol, and the JUPITER trial.

  Lancet (London, England) 20090704

• Rosuvastatin, C-reactive protein, LDL cholesterol, and the JUPITER trial.

  Lancet (London, England) 20090704

• Rosuvastatin in patients undergoing hemodialysis.

  The New England journal of medicine 20090702

• Rosuvastatin in patients undergoing hemodialysis.

  The New England journal of medicine 20090702

• Rosuvastatin in patients undergoing hemodialysis.

  The New England journal of medicine 20090702

• Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice.

  Atherosclerosis 20090701

• Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels.

  Atherosclerosis 20090701

• Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage.

  Metabolism: clinical and experimental 20090701

• Moving toward new statin guidelines in a post-JUPITER world: principles to consider.

  Current atherosclerosis reports 20090701

• Statins and venous thromboembolism: a novel effect of statins?

  Current medical research and opinion 20090701

• The Jupiter trial--new territory for statins?

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090701

• Statin therapy in patients with heart failure and preserved left ventricular function.

  Circulation journal : official journal of the Japanese Circulation Society 20090701

• Safety and efficacy of achieving very low low-density lipoprotein cholesterol levels with rosuvastatin 40 mg daily (from the ASTEROID Study).

  The American journal of cardiology 20090701

• Effect of n-3 polyunsaturated fatty acids and rosuvastatin in patients with heart failure: results of the GISSI-HF trial.

  Expert review of cardiovascular therapy 20090701

• Statins and cardiovascular events in patients with end-stage renal disease on hemodialysis. The AURORA results suggest the need for earlier intervention.

  Current vascular pharmacology 20090701

• Attenuated plaque at nonculprit lesions in patients enrolled in intravascular ultrasound atherosclerosis progression trials.

  JACC. Cardiovascular interventions 20090701

• Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis.

  JACC. Cardiovascular interventions 20090701

• Can statins alter coronary plaque composition assessed by radiofrequency backscatter intravascular ultrasound?

  JACC. Cardiovascular interventions 20090701

• Rosuvastatin inhibits MMP-2 expression and limits the progression of atherosclerosis in LDLR-deficient mice.

  Archives of medical research 20090701

• Rosuvastatin 20 mg restores normal HDL-apoA-I kinetics in type 2 diabetes.

  Journal of lipid research 20090601

• Effects of rosuvastatin and atorvastatin on LDL and HDL particle concentrations in patients with metabolic syndrome: a randomized, double-blind, controlled study.

  Diabetes care 20090601

• Intensive lipid lowering may reduce progression of carotid atherosclerosis within 12 months of treatment: the METEOR study.

  Journal of internal medicine 20090601

• Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection.

  Arteriosclerosis, thrombosis, and vascular biology 20090601

• The effect of rosuvastatin on insulin sensitivity and pancreatic beta-cell function in nondiabetic renal transplant recipients.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20090601

• [The JUPITER study emphasizes primary prevention].

  Lakartidningen 20090601

• The influence of rosuvastatin therapy and percutaneous coronary intervention on angiogenic growth factors in coronary artery disease patients.

  Acta cardiologica 20090601

• [The JUPITER study poses more questions than answers].

  Lakartidningen 20090601

• [JUPITER--think first, act subsequently!].

  Lakartidningen 20090601

• [Treat the primary cause of inflammation in overweight individuals without symptoms of coronary disease].

  Lakartidningen 20090601

• Automated liquid-liquid extraction method for high-throughput analysis of rosuvastatin in human EDTA K2 plasma by LC-MS/MS.

  Bioanalysis 20090601

• The editor's roundtable: the JUPITER trial--initial results and clinical implications.

  The American journal of cardiology 20090515

• Improved pharmacokinetic and bioavailability support of drug discovery using serial blood sampling in mice.

  Journal of pharmaceutical sciences 20090501

• LDL-cholesterol lowering increases plasma apelin in isolated hypercholesterolemia.

  Atherosclerosis 20090501

• Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: a phase 3 study.

  Atherosclerosis 20090501

• Exaggerated benefits of rosuvastatin compared with other statins.

  Pharmacoepidemiology and drug safety 20090501

• Cardiovascular risk reduction: what do recent trials with rosuvastatin tell us?

  Advances in therapy 20090501

• The gravity of JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin).

  Postgraduate medicine 20090501

• [The JUPITER study].

  Giornale italiano di cardiologia (2006) 20090501

• [JUPITER no support of changed guidelines for cardiovascular prevention. Moderate absolute risk reduction and uncertain long term effects].

  Lakartidningen 20090501

• [JUPITER can yield paradigmatic shift in the prevention of cardiovascular disease. Focus on inflammation as a risk factor].

  Lakartidningen 20090501

• Predicting benefit from statins by C-reactive protein, LDL-cholesterol or absolute cardiovascular risk.

  Future cardiology 20090501

• The JUPITER trial: results, controversies, and implications for prevention.

  Circulation. Cardiovascular quality and outcomes 20090501

• JUPITER: a few words of caution.

  Circulation. Cardiovascular quality and outcomes 20090501

• A randomized trial of rosuvastatin in the prevention of venous thromboembolism.

  The New England journal of medicine 20090430

• Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial.

  Lancet (London, England) 20090404

• Bringing JUPITER down to earth.

  Lancet (London, England) 20090404

• Lipid lowering for primary prevention.

  Lancet (London, England) 20090404

• Sunset for statins after AURORA?

  The New England journal of medicine 20090402

• Rosuvastatin and cardiovascular events in patients undergoing hemodialysis.

  The New England journal of medicine 20090402

• Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers.

  Journal of lipid research 20090401

• Effect of atorvastatin versus rosuvastatin on levels of serum lipids, inflammatory markers and adiponectin in patients with hypercholesterolemia.

  Pharmaceutical research 20090401

• Impact of a compliance program on cholesterol control: results of the randomized ORBITAL study in 8108 patients treated with rosuvastatin.

  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20090401

• Lipid-altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolaemic patients inadequately controlled with prior statin monotherapy - The IN-CROSS study.

  International journal of clinical practice 20090401

• Study stirs debate about statin use in those without high cholesterol.

  Mayo Clinic women's healthsource 20090401

• Effects of rosuvastatin and colestimide on metabolic parameters and urinary monocyte chemoattractant protein-1 in type 2 diabetic patients with hyperlipidemia.

  Southern medical journal 20090401

• [Rosuvastatin in patients with chronic heart failure].

  Der Internist 20090401

• Using statins to treat 'healthy' patients: are we there yet?

  Expert review of pharmacoeconomics & outcomes research 20090401

• [The JUPITER trial: a new approach in primary prevention].

  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20090401

• Prevalence of low low-density lipoprotein cholesterol with elevated high sensitivity C-reactive protein in the U.S.: implications of the JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin) study.

  Journal of the American College of Cardiology 20090317

• JUPITER clinical directions--polling results.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Rosuvastatin in patients with elevated C-reactive protein.

  The New England journal of medicine 20090305

• Does rosuvastatin offer therapeutic potential in autoimmune thyroiditis in nonobese diabetic mice?

  Clinical immunology (Orlando, Fla.) 20090301

• Influence of short-term rosuvastatin therapy on endothelial progenitor cells and endothelial function.

  Journal of cardiovascular pharmacology and therapeutics 20090301

• Predictors of fatal and non-fatal outcomes in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): incremental value of apolipoprotein A-1, high-sensitivity C-reactive peptide and N-terminal pro B-type natriuretic peptide.

  European journal of heart failure 20090301

• Rosuvastatin positively changes nerve electrophysiology in diabetic rats.

  Diabetes/metabolism research and reviews 20090301

• JUPITER: wake up and smell the coffee--the absolute and relative merits of statin use.

  International journal of clinical practice 20090301

• Quantitative and qualitative effects of rosuvastatin on LDL-cholesterol: what is the clinical significance?

  International journal of clinical practice 20090301

• JUPITER strikes earth.

  Nature clinical practice. Cardiovascular medicine 20090301

• The Jupiter trial: key findings, controversies, and implications.

  Current cardiology reports 20090301

• Dose-dependent effect of rosuvastatin treatment on HDL-subfraction phenotype in patients with primary hyperlipidemia.

  Journal of cardiovascular pharmacology and therapeutics 20090301

• Rosuvastatin protects against angiotensin II-induced renal injury in a dose-dependent fashion.

  Journal of hypertension 20090301

• Reversal of voltage-dependent erectile responses in the Zucker obese-diabetic rat by rosuvastatin-altered RhoA/Rho-kinase signaling.

  The journal of sexual medicine 20090301

• [The GISSI-HF trial].

  Giornale italiano di cardiologia (2006) 20090301

• The role of C-reactive protein (CRP) and statin treatment in reducing cardiovascular risk.

  South Dakota medicine : the journal of the South Dakota State Medical Association 20090301

• Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.

  The American journal of cardiology 20090215

• [Statin therapy and muscle disorders].

  Orvosi hetilap 20090208

• [JUPITER study about rosuvastatin and risk of cardiovascular disease. Unclear consequences for the guideline].

  Nederlands tijdschrift voor geneeskunde 20090207

• [JUPITER study (2). For now no reason to give statins to more people].

  Nederlands tijdschrift voor geneeskunde 20090207

• [Less vascular risk with rosuvastatin in elevated CRP].

  Nederlands tijdschrift voor geneeskunde 20090207

• [Comment from the lipidologic viewpoint].

  Praxis 20090204

• [Comment from the cardiologic viewpoint].

  Praxis 20090204

• [Comment from the family practice viewpoint].

  Praxis 20090204

• Rosuvastatin protects against podocyte apoptosis in vitro.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090201

• Therapeutic traditions, patient socioeconomic characteristics and physicians' early new drug prescribing--a multilevel analysis of rosuvastatin prescription in south Sweden.

  European journal of clinical pharmacology 20090201

• Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent.

  Drug metabolism and disposition: the biological fate of chemicals 20090201

• Is hsCRP Back on Board? Implications from the JUPITER Trial.

  Clinical chemistry 20090201

• Tracking of high-sensitivity C-reactive protein after an initially elevated concentration: the JUPITER Study.

  Clinical chemistry 20090201

• Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?

  Metabolism: clinical and experimental 20090201

• Once-a-week rosuvastatin (2.5 to 20 mg) in patients with a previous statin intolerance.

  The American journal of cardiology 20090201

• [Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090201

• Reduced efficacy of rosuvastatin by St. John's Wort.

  The American journal of medicine 20090201

• Rosuvastatin given during reperfusion decreases infarct size and inhibits matrix metalloproteinase-2 activity in normocholesterolemic and hypercholesterolemic rabbits.

  Journal of cardiovascular pharmacology 20090201

• Use of statins for the treatment of spontaneous intracerebral hemorrhage: results of a pilot study.

  Central European neurosurgery 20090201

• Efficacy of alternate day versus daily dosing of rosuvastatin.

  The Canadian journal of cardiology 20090201

• N-3 polyunsaturated fatty acids and statins in heart failure.

  Lancet (London, England) 20090131

• Studies examine inflammatory biomarker in prevention and prediction of heart disease.

  JAMA 20090107

• Rosuvastatin prevents endothelial cell death and reduces atherosclerotic lesion formation in ApoE-deficient mice.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090101

• Skin blood flowmotion and microvascular reactivity investigation in hypercholesterolemic patients without clinically manifest arterial diseases.

  Physiological research 20090101

• Models for the analysis of C-reactive protein in statin trials.

  Pharmaceutical statistics 20090101

• Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia.

  Journal of lipid research 20090101

• ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans.

  Journal of clinical pharmacology 20090101

• Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons.

  American journal of physiology. Cell physiology 20090101

• Rationale and design of the carotid plaque in human for all evaluations with aggressive rosuvastatin therapy (CHALLENGER trial): evaluation by magnetic resonance imaging.

  Circulation journal : official journal of the Japanese Circulation Society 20090101

• A case of asymptomatic cytoplasmic body myopathy revealed by sinvastatin.

  Neuromuscular disorders : NMD 20090101

• Surprises and reaffirmations in 2008 clinical trials.

  Cleveland Clinic journal of medicine 20090101

• Jupiter to earth: a statin helps people with normal LDL-C and high hs-CRP, but what does it mean?

  Cleveland Clinic journal of medicine 20090101

• Concern still warranted: medication burden and persistence with lipid-lowering drugs.

  The American journal of managed care 20090101

• Beneficial effect of rosuvastatin on cardiac dysfunction is associated with alterations in calcium-regulatory proteins.

  European journal of heart failure 20090101

• Rosuvastatin induced rhabdomyolysis in a low risk patient: a case report and review of the literature.

  Current clinical pharmacology 20090101

• Comparison of different methods to investigate postprandial lipaemia.

  The Netherlands journal of medicine 20090101

• Jupiter to Earth: CRP promotes atherothrombosis.

  Metabolic syndrome and related disorders 20090101

• Statin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy.

  Xenobiotica; the fate of foreign compounds in biological systems 20090101

• Rosuvastatin in hemodialysis: short-term effects on lipids and C-reactive protein.

  Journal of nephrology 20090101

• [Rosuvastatin and fenofibrate in patients with diabetes and low high density lipoprotein cholesterol: comparison of changes of lipid levels and some markers of inflammation].

  Kardiologiia 20090101

• Rosuvastatin-induced rhabdomyolysis probably via CYP2C9 saturation.

  Drug metabolism and drug interactions 20090101

• Efficacy and safety of rosuvastatin in the management of dyslipidemia.

  Vascular health and risk management 20090101

• Prevention of atherosclerosis in patients living with HIV.

  Vascular health and risk management 20090101

• [Rosuvastatin has no effect on clinical outcomes in patients with heart failure. Results of the GISSI-HF trial].

  Kardiologiia 20090101

• [Effect of therapy with rosuvastatin on circulating endothelial progenitor cells in patients with chronic heart failure].

  Kardiologiia 20090101

• JUPITER study highlights value of anti-inflammatory action of rosuvastatin.

  Cardiovascular journal of Africa 20090101

• The JUPITER trial: How will it change clinical practice?

  Reviews in cardiovascular medicine 20090101

• [Rosuvastatin attenuates vascular endothelial adhesiveness in apolipoprotein E-deficient mice].

  Zhonghua xin xue guan bing za zhi 20090101

• Disappointing recent cholesterol-lowering drug trials: is it not time for a full reappraisal of the cholesterol theory?

  World review of nutrition and dietetics 20090101

• Rosuvastatin does not affect intrarenal hemodynamics in patients with hypercholesterolemia.

  Journal of nephrology 20090101

• Rosuvastatin increased serum osteocalcin levels independent of its serum cholesterol-lowering effect in patients with type 2 diabetes and hypercholesterolemia.

  Internal medicine (Tokyo, Japan) 20090101

• Antimicrobial action of atorvastatin and rosuvastatin.

  Pathology 20090101

• The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences.

  Vascular health and risk management 20090101

• [Rosuvastatin in prevention of cardiac complications following surgical treatment of patients with vascular pathology].

  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20090101

• Comparative single- and multiple-dose pharmacokinetics of rosuvastatin following oral administration in Chinese volunteers.

  European journal of drug metabolism and pharmacokinetics 20090101

• [By JUPITER! Disease mongering!].

  Lakartidningen 20081217

• Comparison of benefits and risks of rosuvastatin versus atorvastatin from a meta-analysis of head-to-head randomized controlled trials.

  The American journal of cardiology 20081215

• [Sequelae of the JUPITER study. What is changing in primary prevention? (interview by Dr. med. Dirk Einecke)].

  MMW Fortschritte der Medizin 20081204

• [Statin cuts cardiovascular risk in half].

  MMW Fortschritte der Medizin 20081204

• Statin cost-effectiveness comparisons using real-world effectiveness data: formulary implications.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20081201

• Acute treatment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20081201

• Effect of omega-3-acid ethyl esters on the steady-state plasma pharmacokinetics of rosuvastatin in healthy adults.

  Expert opinion on pharmacotherapy 20081201

• Clinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HF.

  European journal of heart failure 20081201

• Intensive lipid-lowering therapy for patients with aortic stenosis.

  The American journal of cardiology 20081201

• Superior benefit of aggressive lipid-lowering therapy for high- risk patients using statins: the SUBARU study--more hypercholesterolemic patients achieve Japan Atherosclerosis Society LDL-C goals with rosuvastatin therapy than with atorvastatin therapy.

  Journal of atherosclerosis and thrombosis 20081201

• Effect of rosuvastatin pretreatment on myocardial damage after coronary surgery: a randomized trial.

  The Journal of thoracic and cardiovascular surgery 20081201

• [JUPITER: reduction by rosuvastatin of cardiovascular events and mortality in healthy subjects without hyperlipidaemia but with elevated C-reactive protein].

  Revue medicale de Liege 20081201

• Achieving lipid goals with rosuvastatin compared with simvastatin in high risk patients in real clinical practice: a randomized, open-label, parallel-group, multi-center study: the DISCOVERY-Beta study.

  Vascular health and risk management 20081201

• Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia.

  Vascular health and risk management 20081201

• Letter by Kaneda regarding article, 'Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden'.

  Circulation 20081125

• Letter by Sutton et al regarding article, 'Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden'.

  Circulation 20081125

• Expanding the orbit of primary prevention--moving beyond JUPITER.

  The New England journal of medicine 20081120

• Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

  The New England journal of medicine 20081120

• Cardiovascular health. Statin therapy reduces disease in healthy volunteers--but how, exactly?

  Science (New York, N.Y.) 20081114

• Trial stopped early after rosuvastatin found to cut the risk of heart attack and stroke by 44% in healthy people.

  BMJ (Clinical research ed.) 20081112

• Impact of adherence to statins on chronic heart failure in primary prevention.

  British journal of clinical pharmacology 20081101

• Effects of rosuvastatin on cardiovascular morphology and function in an ApoE-knockout mouse model of atherosclerosis.

  American journal of physiology. Heart and circulatory physiology 20081101

• Rosuvastatin, pravastatin, and atorvastatin for the treatment of hypercholesterolaemia in HIV-infected patients receiving protease inhibitors.

  Current HIV research 20081101

• Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial.

  Lancet (London, England) 20081004

• The safety of rosuvastatin in comparison with other statins in over 25,000 statin users in the Saskatchewan Health Databases.

  Pharmacoepidemiology and drug safety 20081001

• The safety of rosuvastatin in comparison with other statins in over 100,000 statin users in UK primary care.

  Pharmacoepidemiology and drug safety 20081001

• Human proximal tubular epithelium actively secretes but does not retain rosuvastatin.

  Molecular pharmacology 20081001

• Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin.

  Drug metabolism and disposition: the biological fate of chemicals 20081001

• Rosuvastatin reduces intima-media thickness in hypercholesterolemic subjects with asymptomatic carotid artery disease: the Asymptomatic Carotid Atherosclerotic Disease in Manfredonia (ACADIM) Study.

  Expert opinion on pharmacotherapy 20081001

• Treatment of hyperlipidaemia with fenofibrate and related fibrates.

  Expert opinion on investigational drugs 20081001

• Clinical usefulness of tissue Doppler imaging in patients with mild to moderate aortic stenosis: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin study.

  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20080901

• An overview of the extra-lipid effects of rosuvastatin.

  Journal of cardiovascular pharmacology and therapeutics 20080901

• The HMG-CoA reductase inhibitor rosuvastatin and the angiotensin receptor antagonist candesartan attenuate atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes via effects on advanced glycation, oxidative stress and inflammation.

  Diabetologia 20080901

• Participation of K+ channels in the endothelium-dependent and endothelium-independent components of the relaxant effect of rosuvastatin in rat aortic rings.

  Journal of cardiovascular pharmacology and therapeutics 20080901

• Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: investigating differential effects among statins.

  Current medical research and opinion 20080901

• Population pharmacokinetics of rosuvastatin: implications of renal impairment, race, and dyslipidaemia.

  Current medical research and opinion 20080901

• Effect of rosuvastatin on methionine-induced hyperhomocysteinaemia and haematological changes in rats.

  Basic & clinical pharmacology & toxicology 20080901

• Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemia.

  European journal of pharmacology 20080820

• Statin therapy alters the relationship between apolipoprotein B and low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol targets in high-risk patients: the MERCURY II (Measuring Effective Reductions in Cholesterol Using Rosuvastatin) trial.

  Journal of the American College of Cardiology 20080819

• Re-evaluating therapeutic target goals for statin-treated patients: time for revolutionary changes?

  Journal of the American College of Cardiology 20080819

• Rosuvastatin protects against oxidative stress and DNA damage in vitro via upregulation of glutathione synthesis.

  Atherosclerosis 20080801

• Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy.

  Atherosclerosis 20080801

• Effect of silymarin supplement on the pharmacokinetics of rosuvastatin.

  Pharmaceutical research 20080801

• Hepatic nuclear factor 1alpha inhibitor ursodeoxycholic acid influences pharmacokinetics of the organic anion transporting polypeptide 1B1 substrate rosuvastatin and bilirubin.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• Dose-dependent effect of rosuvastatin on VLDL-apolipoprotein C-III kinetics in the metabolic syndrome.

  Diabetes care 20080801

• Same drug, different dosing: differences in dosing for drugs approved in the United States, Europe, and Japan.

  Journal of clinical pharmacology 20080801

• Effects of 20 mg rosuvastatin on VLDL1-, VLDL2-, IDL- and LDL-ApoB kinetics in type 2 diabetes.

  Diabetologia 20080801

• Potential role of statins in the treatment of heart failure.

  Current atherosclerosis reports 20080801

• Lipophilicity and cardiovascular outcome in patients with CHF.

  American heart journal 20080801

• Rosuvastatin and progression of atherosclerosis.

  Expert review of cardiovascular therapy 20080801

• Rosuvastatin: efficacy, safety and clinical effectiveness.

  Expert opinion on pharmacotherapy 20080801

• Intensive lipid intervention in the post-ENHANCE era.

  Mayo Clinic proceedings 20080801

• Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758).

  Journal of neurotrauma 20080801

• Discovery Belux: comparison of rosuvastatin with atorvastatin in hypercholesterolaemia.

  Acta cardiologica 20080801

• Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20080801

• Impact of enhanced compliance initiatives on the efficacy of rosuvastatin in reducing low density lipoprotein cholesterol levels in patients with primary hypercholesterolaemia.

  Swiss medical weekly 20080726

• Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

  Journal of medicinal chemistry 20080710

• Rapid response to lipids profile and leukocyte gene expression after rosuvastatin administration in Chinese healthy volunteers.

  Chinese medical journal 20080705

• [Statin therapy for systolic heart failure. The CORONA trial (Controlled Rosuvastatin Multinational Trial in Heart Failure)].

  Der Internist 20080701

• Rosuvastatin selectively stimulates apolipoprotein A-I but not apolipoprotein A-II synthesis in Hep G2 cells.

  Metabolism: clinical and experimental 20080701

• A multimodal, evidence-based approach to achieve lipid targets in the treatment of antiretroviral-associated dyslipidemia: case report and review of the literature.

  Pharmacotherapy 20080701

• Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: a randomized, single-blind, placebo-controlled, crossover study.

  Clinical therapeutics 20080701

• Cost-effectiveness analysis of rosuvastatin versus atorvastatin, simvastatin, and pravastatin from a Canadian health system perspective.

  Clinical therapeutics 20080701

• Beyond coronary artery disease: rosuvastatin in older patients with ischemic systolic heart failure.

  Journal of the American Geriatrics Society 20080701

• Effect of statins on soluble CD40 ligand in hypercholesterolemic Type 2 diabetic patients.

  Journal of endocrinological investigation 20080701

• Reversible acute hepatitis induced by rosuvastatin.

  Southern medical journal 20080701

• Efficacy of rosuvastatin (5 mg and 10 mg) twice a week in patients intolerant to daily statins.

  The American journal of cardiology 20080615

• Controlled Rosuvastatin Multinational Trial In Heart Failure (the positive negative trial).

  The American journal of cardiology 20080615

• Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes.

  Diabetes research and clinical practice 20080601

• The comparative effectiveness of rosuvastatin vs. other statins in patients with an increased risk of failure to reach NCEP ATP III goal.

  International journal of clinical practice 20080601

• Cost-effectiveness of statins in the prevention of coronary heart disease events in middle-aged Finnish men.

  Current medical research and opinion 20080601

• Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin.

  Journal of cardiovascular pharmacology 20080601

• The relation between extent of coronary artery disease measured by quantitative coronary angiography and changes in lipid profile: insights from trials of atherosclerosis regression.

  The Journal of invasive cardiology 20080601

• [Cardiology 2008].

  Deutsche medizinische Wochenschrift (1946) 20080601

• [Pleiotropic effects of statins].

  Revista medica de Chile 20080601

• Statin, the black box.

  Archives of cardiovascular diseases 20080601

• Effects of rosuvastatin and atorvastatin on the apolipoprotein B/apolipoprotein A-1 ratio in patients with an acute coronary syndrome: The CENTAURUS trial design.

  Archives of cardiovascular diseases 20080601

• Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden.

  Circulation 20080513

• (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.

  Journal of medicinal chemistry 20080508

• Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance: evidence for statin-induced hepatic insulin sensitization.

  Atherosclerosis 20080501

• In vitro anti-oxidant and DNA protective effects of the novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin.

  Clinical and experimental pharmacology & physiology 20080501

• Switching statin therapy using a pharmacist-managed therapeutic conversion program versus usual care conversion among indigent patients.

  Pharmacotherapy 20080501

• I am 72, had a heart attack 16 years ago, and had angioplasty at Cleveland Clinic. My LDL was over 100 and HDL was in the low 30s. I take rosuvastatin and now my LDL is below 70, but my HDL has been driven down also, to 22. I am unable to raise HDL independent of LDL. Is it more important to control LDL below 70 and let HDL find its own level?

  Heart advisor 20080501

• Drug/Drug interaction between lopinavir/ritonavir and rosuvastatin in healthy volunteers.

  Journal of acquired immune deficiency syndromes (1999) 20080415

• Lipid levels after acute coronary syndromes.

  Journal of the American College of Cardiology 20080415

• Lipid levels in the post-acute coronary syndrome setting: destabilizing another myth?

  Journal of the American College of Cardiology 20080415

• Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy.

  Life sciences 20080409

• Indices of reverse cholesterol transport in subjects with metabolic syndrome after treatment with rosuvastatin.

  Atherosclerosis 20080401

• Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosis.

  American journal of physiology. Renal physiology 20080401

• Determinants of CRP level in statin-treated patients.

  Current medical research and opinion 20080401

• Lipid levels and low-density lipoprotein cholesterol goal attainment in diabetic patients: rosuvastatin compared with other statins in usual care.

  Expert opinion on pharmacotherapy 20080401

• The effect of a combination antacid preparation containing aluminium hydroxide and magnesium hydroxide on rosuvastatin pharmacokinetics.

  Current medical research and opinion 20080401

• Gynecomastia possibly induced by rosuvastatin.

  Pharmacotherapy 20080401

• Effects of rosuvastatin and pitavastatin on ischemia-induced myocardial stunning in dogs.

  Journal of pharmacological sciences 20080401

• [The CORONA study].

  Giornale italiano di cardiologia (2006) 20080401

• Clinical efficacy and safety of statins in managing cardiovascular risk.

  Vascular health and risk management 20080401

• Rosuvastatin in older patients with systolic heart failure.

  The New England journal of medicine 20080320

• Dose-dependent effect of rosuvastatin on apolipoprotein B-100 kinetics in the metabolic syndrome.

  Atherosclerosis 20080301

• Early impairment of left ventricular function in hypercholesterolemia and its reversibility after short term treatment with rosuvastatin A preliminary echocardiographic study.

  Atherosclerosis 20080301

• A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia.

  Atherosclerosis 20080301

• The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1.

  Clinical pharmacology and therapeutics 20080301

• The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primary dyslipidemia with hypolipidemic diet treatment.

  Platelets 20080301

• Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance.

  The Annals of pharmacotherapy 20080301

• Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial.

  American heart journal 20080301

• Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats.

  Free radical research 20080301

• An evaluation of rosuvastatin: pharmacokinetics, clinical efficacy and tolerability.

  Expert opinion on drug metabolism & toxicology 20080301

• Efficacy and safety of rosuvastatin in Taiwanese patients.

  Journal of the Chinese Medical Association : JCMA 20080301

• Antiphospholipid antibodies induce vascular functional changes in mice: a mechanism of vascular lesions in antiphospholipid syndrome?

  Lupus 20080301

• [No reason to start treatment with statins in patients with moderate to severe heart failure].

  Nederlands tijdschrift voor geneeskunde 20080301

• The year in valvular heart disease.

  Journal of the American College of Cardiology 20080219

• Rosuvastatin improves basal nitric oxide activity of the renal vasculature in patients with hypercholesterolemia.

  Atherosclerosis 20080201

• Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.

  Clinical pharmacology and therapeutics 20080201

• The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes.

  Atherosclerosis 20080201

• Dose-dependent regulation of high-density lipoprotein metabolism with rosuvastatin in the metabolic syndrome.

  The Journal of clinical endocrinology and metabolism 20080201

• Rosuvastatin provides pleiotropic protection against pulmonary hypertension, right ventricular hypertrophy, and coronary endothelial dysfunction in rats.

  American journal of physiology. Heart and circulatory physiology 20080201

• Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.

  Bioorganic & medicinal chemistry letters 20080201

• Intravenous rosuvastatin for acute stroke treatment: an animal study.

  Stroke 20080201

• Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment.

  Hypertension (Dallas, Tex. : 1979) 20080201

• In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model.

  Pharmacogenetics and genomics 20080201

• Usefulness of statin pretreatment to prevent contrast-induced nephropathy and to improve long-term outcome in patients undergoing percutaneous coronary intervention.

  The American journal of cardiology 20080201

• Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levels.

  The American journal of cardiology 20080201

• Rosuvastatin attenuates angiotensin II-induced neointimal formation after stent implantation in the rat.

  Coronary artery disease 20080201

• Rosuvastatin: characterization of induced myopathy in the rat.

  Toxicologic pathology 20080201

• Statins in the spectrum of neurologic disease.

  Current atherosclerosis reports 20080201

• Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.

  Bioorganic & medicinal chemistry letters 20080115

• Effect of rosuvastatin treatment on plasma visfatin levels in patients with primary hyperlipidemia.

  European journal of pharmacology 20080114

• Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.

  Journal of medicinal chemistry 20080110

• Does hypercholesterolemia impair left ventricular function?

  Atherosclerosis 20080101

• Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury.

  American journal of nephrology 20080101

• Rosuvastatin increases vascular endothelial PPARgamma expression and corrects blood pressure variability in obese dyslipidaemic mice.

  European heart journal 20080101

• Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes.

  Vascular pharmacology 20080101

• CORONA--rosuvastatin in older patients with systolic heart failure.

  International journal of clinical practice 20080101

• Clinical trials update from the American Heart Association 2007: CORONA, RethinQ, MASCOT, AF-CHF, HART, MASTER, POISE and stem cell therapy.

  European journal of heart failure 20080101

• The protective effect of rosuvastatin in human umbilical endothelial cells exposed to constant or intermittent high glucose.

  Journal of diabetes and its complications 20080101

• Attenuation of vascular/neural dysfunction in Zucker rats treated with enalapril or rosuvastatin.

  Obesity (Silver Spring, Md.) 20080101

• Is the Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA) the answer to the cholesterol paradox in heart failure?

  Congestive heart failure (Greenwich, Conn.) 20080101

• [Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)].

  Kardiologiia 20080101

• CORONA, statins, and heart failure: who lost the crown?

  Angiology 20080101

• First head-to-head study comparing rosuvastatin and atorvastatin effects on the treatment of atherosclerosis.

  Cardiovascular journal of Africa 20080101

• Cost-effectiveness of rosuvastatin in the prevention of ischemic heart disease in Portugal.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101

• Rosuvastatin: a review of its effect on atherosclerosis.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101

• Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation.

  Thrombosis research 20080101

• Efficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary hypercholesterolemia: results from the ECLIPSE study.

  Cardiology 20080101

• Rosuvastatin outcomes study JUPITER closes early due to evidence of benefit.

  Cardiovascular journal of Africa 20080101

• [Rosuvastatin for the treatment of dyslipidemia in HIV-infected patients receiving highly active antiretroviral therapy. Preliminary experience].

  Enfermedades infecciosas y microbiologia clinica 20080101

• Rosuvastatin and cardiovascular disease: did the strongest statin hold the initial promises?

  Angiology 20080101

• Effects of low-dose atorvastatin and rosuvastatin on plasma lipid profiles: a long-term, randomized, open-label study in patients with primary hypercholesterolemia.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101

• Effects of lipid-lowering therapy with rosuvastatin on atherosclerotic burden in patients with chronic kidney disease.

  Internal medicine (Tokyo, Japan) 20080101

• Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme.

  Clinical drug investigation 20080101

• [Molecular mechanisms of effects of rosuvastatin on systemic oxidative stress and endogenous inflammation in patients with atherosclerosis].

  Kardiologiia 20080101

• Statin contraindicated in heart failure.

  Angiology 20080101

• Going for gold, from Beijing to Munich, highlights from the ESC 2008 Congress: BEAUTIFUL, GISSI-HF, and potential new therapies for acute decompensated heart failure.

  Cardiovascular therapeutics 20080101

• Low-risk older patients (50 years and older) with raised high-sensitivity CRP (hs-CRP) benefit from rosuvastatin therapy: the JUPITER study.

  Cardiovascular journal of Africa 20080101

• [Influence of rosuvastatin in endothelial function and oxidative stress, in patients with acute coronary syndrome].

  Archivos de cardiologia de Mexico 20080101

• Rosuvastatin regulates vascular smooth muscle cell phenotypic modulation in vascular remodeling: role for the urokinase receptor.

  Atherosclerosis 20071201

• Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin.

  Clinical pharmacology and therapeutics 20071201

• Combination of indomethacin and statin compared with indomethacin and placebo in patients with a first episode of acute pericarditis: preliminary findings.

  Clinical science (London, England : 1979) 20071201

• Statin treatment and 3' polyadenylation of eNOS mRNA.

  Arteriosclerosis, thrombosis, and vascular biology 20071201

• The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems.

  Biopharmaceutics & drug disposition 20071201

• Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein.

  The American journal of cardiology 20071201

• Importance of intensive lipid lowering in acute coronary syndrome and percutaneous coronary intervention.

  Journal of interventional cardiology 20071201

• Improvement in endothelium dysfunction in diabetics treated with statins: a randomized comparison of atorvastatin 20 mg versus rosuvastatin 10 mg.

  Journal of interventional cardiology 20071201

• [Inflammation, atherosclerosis, classic cardiovascular risk factors, biostatistics, clinical significance. Where are we?].

  Revista espanola de cardiologia 20071201

• [Rosuvastatin and metformin decrease inflammation and oxidative stress in patients with hypertension and dyslipidemia].

  Revista espanola de cardiologia 20071201

• Comparison of low-density lipoprotein cholesterol reduction after switching patients on other statins to rosuvastatin or simvastatin in a real-world clinical practice setting.

  The American journal of managed care 20071201

• Dose-dependent effect of rosuvastatin treatment on urinary protein excretion.

  Journal of cardiovascular pharmacology and therapeutics 20071201

• A randomised study comparing the efficacy and safety of rosuvastatin with atorvastatin for achieving lipid goals in clinical practice in Asian patients at high risk of cardiovascular disease (DISCOVERY-Asia study).

  Current medical research and opinion 20071201

• Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity.

  Vascular health and risk management 20071201

• Rosuvastatin in older patients with systolic heart failure.

  The New England journal of medicine 20071129

• Statins for ischemic systolic heart failure.

  The New England journal of medicine 20071129

• Long-term efficacy and safety of rosuvastatin 40 mg in patients with severe hypercholesterolemia.

  The American journal of cardiology 20071101

• Titration patterns with rosuvastatin as compared with other statins in clinical practice: a retrospective observational cohort study using an electronic medical record database.

  Clinical therapeutics 20071101

• Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.

  Bioorganic & medicinal chemistry letters 20071015

• Comparison of effectiveness of rosuvastatin versus atorvastatin on the achievement of combined C-reactive protein (<2 mg/L) and low-density lipoprotein cholesterol (< 70 mg/dl) targets in patients with type 2 diabetes mellitus (from the ANDROMEDA study).

  The American journal of cardiology 20071015

• Effect of rosuvastatin 5-20mg on triglycerides and other lipid parameters in Japanese patients with hypertriglyceridemia.

  Atherosclerosis 20071001

• Efficacy and safety of rosuvastatin 40 mg versus atorvastatin 80 mg in high-risk patients with hypercholesterolemia: results of the POLARIS study.

  Atherosclerosis 20071001

• Differential effect of hypolipidemic drugs on lipoprotein-associated phospholipase A2.

  Arteriosclerosis, thrombosis, and vascular biology 20071001

• Effectiveness of statins in Medicare-eligible patients and patients < 65 years using clinical practice data.

  International journal of clinical practice 20071001

• Pharmacokinetic properties of rosuvastatin after single-dose, oral administration in Chinese volunteers: a randomized, open-label, three-way crossover study.

  Clinical therapeutics 20071001

• Liquid chromatography/negative ion electrospray tandem mass spectrometry method for the quantification of rosuvastatin in human plasma: application to a pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

• The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin.

  The Journal of pharmacology and experimental therapeutics 20070901

• Effectiveness of rosuvastatin in low-density lipoprotein cholesterol lowering and National Cholesterol Education Program Adult Treatment Panel guideline III LDL-C goal attainment compared to other statins among diabetes mellitus patients: a retrospective study using an electronic medical records dataset in the United States.

  Current medical research and opinion 20070901

• Effect of rosuvastatin on outcomes in chronic haemodialysis patients: baseline data from the AURORA study.

  Kidney & blood pressure research 20070901

• Effect of rosuvastatin versus atorvastatin treatment on paraoxonase-1 activity in men with established cardiovascular disease and a low HDL-cholesterol.

  Current medical research and opinion 20070901

• Elevated serum transaminase levels resulting from concomitant use of rosuvastatin and amiodarone.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070901

• The safety of rosuvastatin: effects on renal and hepatic function.

  Expert opinion on drug safety 20070901

• Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901

• McArdle disease with rhabdomyolysis induced by rosuvastatin: case report.

  Arquivos de neuro-psiquiatria 20070901

• Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice.

  The American journal of geriatric pharmacotherapy 20070901

• Preventive effects of bicarbonate on cerivastatin-induced apoptosis.

  International journal of pharmaceutics 20070816

• Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.

  Bioorganic & medicinal chemistry 20070815

• Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

  Bioorganic & medicinal chemistry letters 20070815

• Chronic monotherapy with rosuvastatin prevents progressive left ventricular dysfunction and remodeling in dogs with heart failure.

  Journal of the American College of Cardiology 20070807

• Influence of rosuvastatin on the NAD(P)H oxidase activity in the retina and electroretinographic response of spontaneously hypertensive rats.

  British journal of pharmacology 20070801

• METEOR: aiming at the stars for asymptomatic carotid artery atherosclerosis?

  International journal of clinical practice 20070801

• Effects of once weekly rosuvastatin among patients with a prior statin intolerance.

  The American journal of cardiology 20070801

• Ask the doctor. Are Lipitor and Crestor equally good for me?

  Harvard heart letter : from Harvard Medical School 20070801

• Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection.

  Canadian journal of physiology and pharmacology 20070801

• Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study.

  Vascular health and risk management 20070801

• Role of Rac1 GTPase activation in atrial fibrillation.

  Journal of the American College of Cardiology 20070724

• Effects of rosuvastatin on 3-nitrotyrosine and aortic stiffness in hypercholesterolemia.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20070701

• A 12-week, prospective, open-label analysis of the effect of rosuvastatin on triglyceride-rich lipoprotein metabolism in patients with primary dyslipidemia.

  Clinical therapeutics 20070701

• Quantitative determination of rosuvastatin in human plasma by ion pair liquid-liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20070628

• Comparative effects on lipid levels of combination therapy with a statin and extended-release niacin or ezetimibe versus a statin alone (the COMPELL study).

  Atherosclerosis 20070601

• Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation.

  American journal of physiology. Heart and circulatory physiology 20070601

• Rosuvastatin restores superoxide dismutase expression and inhibits accumulation of oxidized LDL in the aortic arch of obese dyslipidemic mice.

  British journal of pharmacology 20070601

• Comparison of rosuvastatin versus atorvastatin in South-Asian patients at risk of coronary heart disease (from the IRIS Trial).

  The American journal of cardiology 20070601

• Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis: the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) trial.

  American heart journal 20070601

• Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells.

  Journal of cardiovascular pharmacology 20070601

• Rosuvastatin reduces interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP-dependent fashion.

  International journal of clinical pharmacology and therapeutics 20070601

• Spectrophotometric determination of rosuvastatin calcium in tablets.

  Die Pharmazie 20070601

• Personalised medicine: who is an Asian?

  Lancet (London, England) 20070526

• Rosuvastatin reduces gliosis and the accelerated weight gain observed in WT and ApoE-/- mice exposed to a high cholesterol diet.

  Neuroscience letters 20070523

• Improved endothelial function and reduced platelet activation by chronic HMG-CoA-reductase inhibition with rosuvastatin in rats with streptozotocin-induced diabetes mellitus.

  Biochemical pharmacology 20070501

• Interactions between statins and Penicillium chrysogenum antifungal protein (PAF) to inhibit the germination of sporangiospores of different sensitive Zygomycetes.

  FEMS microbiology letters 20070501

• Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats.

  Endocrinology 20070501

• Rosuvastatin displays anti-atherothrombotic and anti-inflammatory properties in apoE-deficient mice.

  Pharmacological research 20070501

• Effects of rosuvastatin on lipids, lipoproteins and apolipoproteins in the dyslipidaemia of diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20070501

• Statin wars: emphasis on potency vs event reduction and safety?

  Mayo Clinic proceedings 20070501

• Achieving low-density lipoprotein cholesterol goals in high-risk patients in managed care: comparison of rosuvastatin, atorvastatin, and simvastatin in the SOLAR trial.

  Mayo Clinic proceedings 20070501

• Comparative effectiveness of rosuvastatin versus other statin therapies in patients at increased risk of failure to achieve low-density lipoprotein goals.

  Current medical research and opinion 20070501

• Will drugs someday reverse CAD? Three recent advances bring the possibility closer to reality.

  Heart advisor 20070501

• Use of high-sensitivity CRP to predict first cardiovascular events.

  Lancet (London, England) 20070414

• Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats.

  The American journal of pathology 20070401

• Statins for aortic valve narrowing?

  Harvard heart letter : from Harvard Medical School 20070401

• [Compared with atorvastatin at the dose of 10 mg per day rosuvastatin was more effective to reach an LDL goal of < 1.00 g/l in high cardiovascular risk patients (ARIANE study)].

  Annales de cardiologie et d'angeiologie 20070401

• Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial.

  JAMA 20070328

• Efficacy and safety of rosuvastatin 40 mg alone or in combination with ezetimibe in patients at high risk of cardiovascular disease (results from the EXPLORER study).

  The American journal of cardiology 20070301

• Comparison of the effects of high doses of rosuvastatin versus atorvastatin on the subpopulations of high-density lipoproteins.

  The American journal of cardiology 20070301

• Rosuvastatin: a highly potent statin for the prevention and management of coronary artery disease.

  Expert review of cardiovascular therapy 20070301

• The GALAXY Program: an update on studies investigating efficacy and tolerability of rosuvastatin for reducing cardiovascular risk.

  Expert review of cardiovascular therapy 20070301

• Carotid intima-media thickness in low-risk individuals with asymptomatic atherosclerosis: baseline data from the METEOR study.

  Current medical research and opinion 20070301

• By the way, doctor. I am 80 and am taking a 40-milligram Crestor pill every day. Recently I saw a Crestor ad that said blood tests should be done to monitor for possible side effects of liver or muscle injury. Can you tell me something about those tests?

  Harvard health letter 20070301

• [The efficacy and safety of rosuvastatin on treating patients with hypercholesterolemia in Chinese: a randomized, double-blind, multi-center clinical trial].

  Zhonghua xin xue guan bing za zhi 20070301

• Asymptomatic hypothyroidism and statin-induced myopathy.

  Canadian family physician Medecin de famille canadien 20070301

• Liver toxicity of rosuvastatin therapy.

  World journal of gastroenterology 20070227

• Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis.

  Journal of the American College of Cardiology 20070206

• Effectiveness of rosuvastatin versus atorvastatin in reducing lipid levels and achieving low-density-lipoprotein cholesterol goals in a usual care setting.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070201

• Rationale and design for a study using intravascular ultrasound to evaluate effects of rosuvastatin on coronary artery atheroma in Japanese subjects: COSMOS study (Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects).

  Circulation journal : official journal of the Japanese Circulation Society 20070201

• Double-blind, randomized, placebo-controlled study of high-dose HMG CoA reductase inhibitor therapy on ventricular remodeling, pro-inflammatory cytokines and neurohormonal parameters in patients with chronic systolic heart failure.

  Journal of cardiac failure 20070201

• Myopathy caused by a combination rosuvastatin and fenofibrate.

  The Journal of the Association of Physicians of India 20070201

• Antioxidant and antiplatelet effects of rosuvastatin in a hamster model of prediabetes.

  Free radical biology & medicine 20070115

• Monday, Wednesday, and Friday dosing of rosuvastatin in patients previously intolerant to statin therapy.

  The American journal of cardiology 20070115

• Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells.

  American journal of nephrology 20070101

• Safety profile of rosuvastatin: results of a prescription-event monitoring study of 11,680 patients.

  Drug safety 20070101

• Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats.

  American journal of therapeutics 20070101

• Diabetes and metabolic syndrome (MS).

  Archives of gerontology and geriatrics 20070101

• Safety of rosuvastatin: update on 16,876 rosuvastatin-treated patients in a multinational clinical trial program.

  Cardiology 20070101

• Evaluation of a novel tablet splitter.

  Journal of the American Pharmacists Association : JAPhA 20070101

• Statin's cost-effectiveness: a Canadian analysis of commonly prescribed generic and brand name statins.

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20070101

• [Treatment for dyslipidemias in patients with arterial hypertension].

  Terapevticheskii arkhiv 20070101

• Ezetimibe is effective when added to maximally tolerated lipid lowering therapy in patients with HIV.

  Lipids in health and disease 20070101

• Effects of statins, fibrates, rosuvastatin, and ezetimibe beyond cholesterol: the modulation of LDL size and subclasses in high-risk patients.

  Advances in therapy 20070101

• Effect of medium pH on the cytotoxicity of hydrophilic statins.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101

• Effects of rosuvastatin on glomerular capillary size-selectivity function in rats with renal mass ablation.

  American journal of nephrology 20070101

• Rosuvastatin in elderly patients.

  Drugs & aging 20070101

• Are HIV positive patients resistant to statin therapy?

  Lipids in health and disease 20070101

• Pharmacokinetics and pharmacodynamics of combined use of lopinavir/ritonavir and rosuvastatin in HIV-infected patients.

  Antiviral therapy 20070101

• [Massive lower gastrointestinal bleeding due to diverticular disease during antiplatelet therapy. Case report].

  Il Giornale di chirurgia 20070101

• Reduction of intima-media thickness in subjects with asymptomatic carotid disease: two cases from the Asymptomatic Carotid Atherosclerosis DIsease Manfredonia Study (ACADIM Study).

  La Clinica terapeutica 20070101

• CORONA study highlights challenges of treating older patients with systolic heart failure.

  Cardiovascular journal of Africa 20070101

• Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for quantification of rosuvastatin in small volume human plasma samples and its application to a clinical study.

  Arzneimittel-Forschung 20070101

• [Effect of statin therapy on dynamics of vascular endothelial growth factor and fibroblast growth factor in patients with ischemic heart disease].

  Kardiologiia 20070101

• [Effect of rosuvastatin therapy and myocardial revascularization on angiogenesis in coronary artery disease patients].

  Kardiologiia 20070101

• [Influence of perindopril, rosuvastatin, or omega-3 polyunsaturated fatty acids on efficacy of antirecurrence therapy with sotalol in patients with persistent atrial fibrillation].

  Kardiologiia 20070101

• [Coronary perfusion, necrosis area, pumping function of the myocardium, and cardiac electrical stability following revascularisation of infarction-affected myocardium].

  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20070101

• Highly active antiretroviral therapy attenuates re-endothelialization and alters neointima formation in the rat carotid artery after balloon injury.

  Journal of acquired immune deficiency syndromes (1999) 20061201

• Rapid immunomodulation by rosuvastatin in patients with acute coronary syndrome.

  European heart journal 20061201

• Treatment with rosuvastatin for severe dyslipidemia in patients with schizophrenia and schizoaffective disorder.

  The Journal of clinical psychiatry 20061201

• Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males.

  Clinica chimica acta; international journal of clinical chemistry 20061101

• Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20061101

• Simultaneous quantitation of rosuvastatin and gemfibrozil in human plasma by high-performance liquid chromatography and its application to a pharmacokinetic study.

  Biomedical chromatography : BMC 20061101

• Efficacy and safety of rosuvastatin every other day compared with once daily in patients with hypercholesterolemia.

  The Annals of pharmacotherapy 20061101

• Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia.

  Journal of clinical pharmacology 20061101

• Effectiveness and cost-effectiveness of rosuvastatin, atorvastatin, and simvastatin among high-risk patients in usual clinical practice.

  The American journal of managed care 20061101

• Expanding options with a wider range of rosuvastatin doses.

  Clinical therapeutics 20061101

• High-dose statins and atherosclerosis regression.

  JAMA 20061018

• High-dose statins and atherosclerosis regression.

  JAMA 20061018

• High-dose statins and atherosclerosis regression.

  JAMA 20061018

• Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats.

  Neuroscience letters 20061002

• Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect.

  Journal of lipid research 20061001

• Ezetimibe/simvastatin single tablet versus rosuvastatin in patients with hypercholesterolemia.

  Current medical research and opinion 20061001

• Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus rosuvastatin in hypercholesterolemic patients.

  Current medical research and opinion 20061001

• A projection of the impact of lipid-lowering therapy on high-risk employee disability and medical costs.

  Journal of occupational and environmental medicine 20061001

• Coronary atherosclerosis can regress with very intensive statin therapy.

  Cleveland Clinic journal of medicine 20061001

• Comparison of rosuvastatin versus atorvastatin in Hispanic-Americans with hypercholesterolemia (from the STARSHIP trial).

  The American journal of cardiology 20060915

• Atorvastatin for stroke prevention.

  The Medical letter on drugs and therapeutics 20060911

• Determination of rosuvastatin in rat plasma by HPLC: Validation and its application to pharmacokinetic studies.

  Biomedical chromatography : BMC 20060901

• Rhabdomyolysis associated with pomegranate juice consumption.

  The American journal of cardiology 20060901

• Impact of rosuvastatin use on costs and outcomes in patients at high risk for cardiovascular disease in US managed care and medicare populations: A data analysis.

  Clinical therapeutics 20060901

• I've just been diagnosed with atherosclerosis. Is there anything I can do to unclog my arteries?

  The Johns Hopkins medical letter health after 50 20060901

• Short-term memory loss associated with rosuvastatin.

  Pharmacotherapy 20060801

• Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy.

  Cardiovascular research 20060715

• Rosuvastatin safety: a comprehensive, international pharmacoepidemiology programme.

  Pharmacoepidemiology and drug safety 20060701

• Results from a rosuvastatin historical cohort study in more than 45,000 Dutch statin users, a PHARMO study.

  Pharmacoepidemiology and drug safety 20060701

• The comparative safety of rosuvastatin: a retrospective matched cohort study in over 48,000 initiators of statin therapy.

  Pharmacoepidemiology and drug safety 20060701

• Med could reverse arterial blockages.

  Health news (Waltham, Mass.) 20060701

• [High lowering of lipids can melt coronary plaques -- is coronary disease reversible?].

  MMW Fortschritte der Medizin 20060615

• Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway.

  British journal of pharmacology 20060601

• Rosuvastatin, a new HMG-CoA reductase inhibitor, reduces the colonic inflammatory response in dextran sulfate sodium-induced colitis in mice.

  International journal of molecular medicine 20060601

• Effect of short-term rosuvastatin treatment on estimated glomerular filtration rate.

  The American journal of cardiology 20060601

• The clinical relevance of low-density-lipoproteins size modulation by statins.

  Cardiovascular drugs and therapy 20060601

• Treating to target patients with primary hyperlipidaemia: comparison of the effects of ATOrvastatin and ROSuvastatin (the ATOROS study).

  Current medical research and opinion 20060601

• Achieving 2003 European lipid goals with rosuvastatin and comparator statins in 6743 patients in real-life clinical practice: DISCOVERY meta-analysis.

  Current medical research and opinion 20060601

• Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies.

  Clinical therapeutics 20060601

• Spinning stars: ASTEROID's impact on atherosclerosis.

  Lancet (London, England) 20060520

• Statin therapy might be beneficial for patients with ankylosing spondylitis.

  Annals of the rheumatic diseases 20060501

• ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein.

  Drug metabolism and disposition: the biological fate of chemicals 20060501

• An overview of statin-associated proteinuria.

  Drug discovery today 20060501

• Rosuvastatin: a safe and effective treatment for dyslipidaemia associated with non-alcoholic steatohepatitis (NASH).

  Scandinavian journal of gastroenterology 20060501

• Achieving LDL cholesterol, non-HDL cholesterol, and apolipoprotein B target levels in high-risk patients: Measuring Effective Reductions in Cholesterol Using Rosuvastatin therapY (MERCURY) II.

  American heart journal 20060501

• Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

  Gastroenterology 20060501

• Clinical trials update from the American College of Cardiology: Darbepoetin alfa, ASTEROID, UNIVERSE, paediatric carvedilol, UNLOAD and ICELAND.

  European journal of heart failure 20060501

• ASTEROID--when spinning a star leads to a collision with reality.

  International journal of clinical practice 20060501

• Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints.

  Reviews on recent clinical trials 20060501

• Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein.

  World journal of gastroenterology 20060407

• Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.

  JAMA 20060405

• Effects of rosuvastatin on postprandial leukocytes in mildly hyperlipidemic patients with premature coronary sclerosis.

  Atherosclerosis 20060401

• Effect of rosuvastatin or atorvastatin on urinary albumin excretion and renal function in type 2 diabetic patients.

  Diabetes research and clinical practice 20060401

• Effect of rosuvastatin compared with other statins on lipid levels and National Cholesterol Education Program goal attainment for low-density lipoprotein cholesterol in a usual care setting.

  Pharmacotherapy 20060401

• 3-HMG-Coenzyme A reductase inhibition and extracellular matrix gene expression in the pressure-overloaded rat heart.

  Journal of cardiovascular pharmacology 20060401

• [Clinical study of the month: ASTEROID: regression of coronary atherosclerosis with rosuvastatin at a maximal daily dose of 40 mg].

  Revue medicale de Liege 20060401

• Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307

• Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia.

  Atherosclerosis 20060301

• Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies.

  Biomedical chromatography : BMC 20060301

• Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production.

  American journal of physiology. Heart and circulatory physiology 20060301

• Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport.

  Pharmaceutical research 20060301

• Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy.

  British journal of clinical pharmacology 20060301

• Statin-associated myasthenia gravis: report of 4 cases and review of the literature.

  Medicine 20060301

• Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats.

  Journal of cardiovascular pharmacology 20060301

• Treatment of hypercholesterolemia in patients with metabolic syndrome: how do different statins compare?

  Nature clinical practice. Endocrinology & metabolism 20060301

• Cross-talk between dyslipidemia and renin-angiotensin system and the role of LOX-1 and MAPK in atherogenesis studies with the combined use of rosuvastatin and candesartan.

  Atherosclerosis 20060201

• Statins prevent dextrose-induced endothelial barrier dysfunction, possibly through inhibition of superoxide formation.

  Diabetes 20060201

• [Statins in patients with kidney failure: efficacy, tolerance, and prescription guidelines in patients with chronic kidney disease and renal transplant].

  Presse medicale (Paris, France : 1983) 20060201

• Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)--can C-reactive protein be used to target statin therapy in primary prevention?

  The American journal of cardiology 20060116

• Comparison of efficacy and safety of rosuvastatin versus atorvastatin in African-American patients in a six-week trial.

  The American journal of cardiology 20060115

• Rosuvastatin as a novel treatment of non-alcoholic fatty liver disease in hyperlipidemic patients.

  Atherosclerosis 20060101

• Rosuvastatin as treatment for non alcoholic steatohepatitis (NASH) and highly active antiretroviral therapy (HAART)-dyslipidaemia: new treatment for global dangers.

  Medical hypotheses 20060101

• Statins and osteoporosis: new role for old drugs.

  The Journal of pharmacy and pharmacology 20060101

• Liquid chromatography/negative ion electrospray tandem mass spectrometry method for the quantification of fluvastatin in human plasma: validation and its application to pharmacokinetic studies.

  Rapid communications in mass spectrometry : RCM 20060101

• Quantitative determination of rosuvastatin in human plasma by liquid chromatography with electrospray ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• [Effect of therapy with rosuvastatin on lipid spectrum, factors of inflammation and endothelial function in patients with ischemic heart disease].

  Kardiologiia 20060101

• [Pronounced lowering of low density cholesterol combined with elevation of high density cholesterol was associated with reduction of coronary atheroma. Results of ASTEROID trial].

  Kardiologiia 20060101

• Is rosuvastatin really a more efficient therapeutic option than atorvastatin?

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20060101

• Rosuvastatin: an independent analysis of risks and benefits.

  MedGenMed : Medscape general medicine 20060101

• How safe is aggressive statin therapy?

  Progress in cardiovascular nursing 20060101

• Analysis of rosuvatatin by imaging mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• The protective effect of rosuvastatin on ischemic brain injury and its mechanism.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

• A comparative study with rosuvastatin in subjects with metabolic syndrome: results of the COMETS study.

  European heart journal 20051201

• Achieving lipid goals in real life: the Dutch DISCOVERY study.

  International journal of clinical practice 20051201

• Blockade of geranylgeranylation by rosuvastatin upregulates eNOS expression in human venous endothelial cells.

  Biochemical and biophysical research communications 20051104

• Effect of rosuvastatin on C-reactive protein and renal function in patients with chronic kidney disease.

  The American journal of cardiology 20051101

• LDL-C/HDL-C ratio in subjects with cardiovascular disease and a low HDL-C: results of the RADAR (Rosuvastatin and Atorvastatin in different Dosages And Reverse cholesterol transport) study.

  Current medical research and opinion 20051101

• Rosuvastatin is cost-effective compared with atorvastatin in reaching cholesterol goals.

  International journal of cardiology 20051010

• Pharmacodynamic evaluation of warfarin and rosuvastatin co-administration in healthy subjects.

  European journal of clinical pharmacology 20051001

• Statins ameliorate endothelial barrier permeability changes in the cerebral tissue of streptozotocin-induced diabetic rats.

  Diabetes 20051001

• Ethnic differences in statin disposition.

  Clinical pharmacology and therapeutics 20051001

• Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment.

  Clinical pharmacology and therapeutics 20051001

• A statin in the treatment of heart failure? Controlled rosuvastatin multinational study in heart failure (CORONA): study design and baseline characteristics.

  European journal of heart failure 20051001

• [Hypolipidemic treatment under special conditions: posttransplant and/or immunosuppressive therapy].

  Arquivos brasileiros de cardiologia 20051001

• Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.

  Journal of pharmaceutical and biomedical analysis 20050915

• Binding thermodynamics of statins to HMG-CoA reductase.

  Biochemistry 20050906

• Effect of rosuvastatin on insulin sensitivity in patients with familial combined hyperlipidaemia.

  European journal of clinical investigation 20050901

• Rosuvastatin: a risk-benefit assessment for intensive lipid lowering.

  Expert opinion on pharmacotherapy 20050901

• Effects of rosuvastatin on endothelial function in patients with familial combined hyperlipidaemia (FCH).

  Current medical research and opinion 20050901

• Using Crestor--and all statins--safely. Some simple steps can help minimize or avoid muscle problems from these cholesterol-lowering drugs.

  Harvard heart letter : from Harvard Medical School 20050901

• [Pharmacological and clinical profile of rosuvastatin calcium (Crestor)].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20050901

• Pharmacologic options for aggressive low-density lipoprotein cholesterol lowering: benefits versus risks.

  The American journal of cardiology 20050822

• Effect of rosuvastatin on warfarin pharmacodynamics and pharmacokinetics.

  Journal of clinical pharmacology 20050801

• Rosuvastatin treatment protects against nitrate-induced oxidative stress.

  Journal of cardiovascular pharmacology 20050801

• Myalgia, hyper-CK-aemia, and hypocoagulability in a patient under rosuvastatin and warfarin.

  European journal of neurology 20050801

• The DISCOVERY PENTA study: a DIrect Statin COmparison of LDL-C Value--an Evaluation of Rosuvastatin therapY compared with atorvastatin.

  Current medical research and opinion 20050801

• Not all statins interfere with clopidogrel during antiplatelet therapy.

  European journal of clinical investigation 20050801

• Safety and efficacy of rosuvastatin therapy for the prevention of hyperlipidemia in adult cardiac transplant recipients.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050801

• New light on statin side effects. What recent research on the cholesterol drugs means to you.

  Heart advisor 20050801

• Drug induced pancreatitis might be a class effect of statin drugs.

  JOP : Journal of the pancreas 20050708

• Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy.

  Circulation 20050705

• Comparison of rosuvastatin with atorvastatin, simvastatin and pravastatin in achieving cholesterol goals and improving plasma lipids in hypercholesterolaemic patients with or without the metabolic syndrome in the MERCURY I trial.

  Diabetes, obesity & metabolism 20050701

• Rosuvastatin for the treatment of hyperlipidaemia in HIV-infected patients receiving protease inhibitors: a pilot study.

  AIDS (London, England) 20050701

• Lipid altering-efficacy of ezetimibe co-administered with simvastatin compared with rosuvastatin: a meta-analysis of pooled data from 14 clinical trials.

  Current medical research and opinion 20050701

• Rosuvastatin for the treatment of hypercholesterolemia.

  Pharmacotherapy 20050701

• The issue of statin safety: where do we stand?

  Circulation 20050614

• The safety of rosuvastatin as used in common clinical practice: a postmarketing analysis.

  Circulation 20050614

• Rhabdomyolysis with cardiac involvement and acute renal failure in a patient taking rosuvastatin and fenofibrate.

  Annals of internal medicine 20050607

• Abstracts of the XV International Symposium on Drugs Affecting Lipid Metabolism, 24-27 October, 2004, Venice, Italy.

  International journal of clinical practice. Supplement 20050601

• Cost effectiveness of rosuvastatin in treating patients to low-density lipoprotein cholesterol goals compared with atorvastatin, pravastatin, and simvastatin (a US Analysis of the STELLAR Trial).

  The American journal of cardiology 20050601

• Cholesterol-lowering effects of rosuvastatin compared with atorvastatin in patients with type 2 diabetes -- CORALL study.

  Journal of internal medicine 20050601

• Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts.

  Cardiovascular research 20050601

• Rosuvastatin-acenocoumarol interaction.

  Clinical therapeutics 20050601

• Efficacy and safety of rosuvastatin in treatment of dyslipidemia.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050515

• Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice.

  The Journal of pharmacology and experimental therapeutics 20050501

• Rosuvastatin reduces platelet activation in heart failure: role of NO bioavailability.

  Arteriosclerosis, thrombosis, and vascular biology 20050501

• Effects of switching statins on lipid and apolipoprotein ratios in the MERCURY I study.

  International journal of cardiology 20050420

• Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion.

  American journal of physiology. Heart and circulatory physiology 20050401

• Upregulation of hepatic LDL receptor-related protein in nephrotic syndrome: response to statin therapy.

  American journal of physiology. Endocrinology and metabolism 20050401

• Rosuvastatin, but not simvastatin, provides end-organ protection in stroke-prone rats by antiinflammatory effects.

  Arteriosclerosis, thrombosis, and vascular biology 20050301

• Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA reductase.

  Bioorganic & medicinal chemistry letters 20050215

• Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA).

  Bioorganic & medicinal chemistry letters 20050215

• Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor but does not depend on endothelial NO synthase.

  Stroke 20050201

• Effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on atherogenic dyslipidemia in patients with characteristics of the metabolic syndrome.

  The American journal of cardiology 20050201

• Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level.

  Acta physiologica Scandinavica 20050201

• Rosuvastatin is cost-effective in treating patients to low-density lipoprotein-cholesterol goals compared with atorvastatin, pravastatin and simvastatin: analysis of the STELLAR trial.

  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20050201

• Comparative effects of rosuvastatin and gemfibrozil on glucose, insulin, and lipid metabolism in insulin-resistant, nondiabetic patients with combined dyslipidemia.

  The American journal of cardiology 20050115

• Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-leiden mice.

  Journal of cardiovascular pharmacology 20050101

• Rosuvastatin exerts favourable effects on thrombosis and neointimal growth in a mouse model of endothelial injury.

  Thrombosis and haemostasis 20050101

• Review of efficacy of rosuvastatin 5 mg.

  International journal of clinical practice 20050101

• Statins and the response to myocardial injury.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

• [Efficacy of lipid correcting therapy with the use of rosuvastatin].

  Kardiologiia 20050101

• Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2.

  Neuroscience 20050101

• Plaque composition changes on rosuvastatin treatment.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20050101

• New warning for statin drug.

  FDA consumer 20050101

• Rosuvastatin: a high-potency HMG-CoA reductase inhibitor.

  Journal of the American Pharmacists Association : JAPhA 20050101

• Determination of rosuvastatin in the presence of its degradation products by a stability-indicating LC method.

  Journal of AOAC International 20050101

• Starting with rosuvastatin in primary hyperlipidemia--Is there more than lipid lowering?

  Angiology 20050101

• [A treatment with rosuvastatin induced a reduction of arterial pressure and a decrease of oxidative stress in spontaneously hypertensive rats].

  Archives des maladies du coeur et des vaisseaux 20050101

• Decreasing LDL cholesterol and medication cost with every-other-day statin therapy.

  Preventive cardiology 20050101

• Considerations in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation.

  Preventive cardiology 20050101

• Cost-effectiveness of rosuvastatin compared with other statins from a managed care perspective.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20050101

• [Treatment of chronic heart failure. The time of statins?].

  Kardiologiia 20050101

• Complications and side effects. Crestor tested in PHAs.

  TreatmentUpdate 20050101

• Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1.

  Biochemical and biophysical research communications 20041217

• Rosuvastatin and the statin wars--the way to peace.

  Lancet (London, England) 20041201

• Assessment of the efficacy of different statins in murine collagen-induced arthritis.

  Arthritis and rheumatism 20041201

• Economic evaluation of a compliance-enhancing intervention in patients with hypercholesterolemia: design and baseline results of the Open Label Primary Care Study: Rosuvastatin Based Compliance Initiatives To Achievements of LDL Goals (ORBITAL) study.

  American heart journal 20041201

• Rosuvastatin reduces caspase-3 activity and up-regulates alpha-secretase in human neuroblastoma SH-SY5Y cells exposed to A beta.

  Neuroscience letters 20041123

• Recurrent acute pancreatitis possibly induced by atorvastatin and rosuvastatin. Is statin induced pancreatitis a class effect?

  JOP : Journal of the pancreas 20041110

• Autosomal recessive hypercholesterolaemia: normalization of plasma LDL cholesterol by ezetimibe in combination with statin treatment.

  Journal of internal medicine 20041101

• Rosuvastatin safety: lessons from the FDA review and post-approval surveillance.

  Expert opinion on drug safety 20041101

• Statins: can the new generation make an impression?

  Expert opinion on emerging drugs 20041101

• Twelve-week, multicenter, randomized, open-label comparison of the effects of rosuvastatin 10 mg/d and atorvastatin 10 mg/d in high-risk adults: a DISCOVERY study.

  Clinical therapeutics 20041101

• Efficacy and safety of rosuvastatin alone and in combination with cholestyramine in patients with severe hypercholesterolemia: a randomized, open-label, multicenter trial.

  Clinical therapeutics 20041101

• Inhibitory effect of candesartan and rosuvastatin on CD40 and MMPs expression in apo-E knockout mice: novel insights into the role of RAS and dyslipidemia in atherogenesis.

  Journal of cardiovascular pharmacology 20041001

• Lipid-modifying effects of rosuvastatin in postmenopausal women with hypercholesterolemia who are receiving hormone replacement therapy.

  Current medical research and opinion 20041001

• Safety of rosuvastatin.

  The American journal of cardiology 20041001

• Should rosuvastatin be withdrawn from the market?

  Lancet (London, England) 20041001

• Should rosuvastatin be withdrawn from the market?

  Lancet (London, England) 20041001

• Should rosuvastatin be withdrawn from the market?

  Lancet (London, England) 20041001

• Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals. 2003.

  Atherosclerosis. Supplements 20041001

• A review of the efficacy of rosuvastatin in patients with type 2 diabetes.

  International journal of clinical practice. Supplement 20041001

• [Hypercholesterolemia, practical guidelines].

  Presse medicale (Paris, France : 1983) 20040925

• Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells.

  Journal of the American Society of Nephrology : JASN 20040901

• New drugs 04. Part III.

  Nursing 20040901

• The level playing field.

  Alternative medicine review : a journal of clinical therapeutic 20040901

• Rosuvastatin in the management of hyperlipidemia.

  Clinical therapeutics 20040901

• Effects of rosuvastatin versus atorvastatin, simvastatin, and pravastatin on non-high-density lipoprotein cholesterol, apolipoproteins, and lipid ratios in patients with hypercholesterolemia: additional results from the STELLAR trial.

  Clinical therapeutics 20040901

• Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine.

  Clinical pharmacology and therapeutics 20040801

• Rationale and design of the GISSI heart failure trial: a large trial to assess the effects of n-3 polyunsaturated fatty acids and rosuvastatin in symptomatic congestive heart failure.

  European journal of heart failure 20040801

• Pharmacodynamic interaction between ezetimibe and rosuvastatin.

  Current medical research and opinion 20040801

• Rosuvastatin: new preparation. Opt for statins with evidence of efficacy on clinical outcome.

  Prescrire international 20040801

• Rosuvastatin (Crestor) and rhabdomyolysis.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20040720

• Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia.

  The American journal of cardiology 20040715

• Rosuvastatin treatment reverses impaired coronary artery vasodilation in fructose-fed, insulin-resistant rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20040701

• Efficacy and safety of rosuvastatin and atorvastatin in patients with hypercholesterolemia and a high risk of coronary heart disease: a randomized, controlled trial.

  American heart journal 20040701

• Safety and efficacy of rosuvastatin.

  Lancet (London, England) 20040701

• Dangers of rosuvastatin identified before and after FDA approval.

  Lancet (London, England) 20040626

• Diagnosing familial combined hyperlipidemia.

  Circulation 20040622

• Update on statins.

  Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing 20040601

• Quantification of the N-desmethyl metabolite of rosuvastatin in human plasma by automated SPE followed by HPLC with tandem MS detection.

  Journal of pharmaceutical and biomedical analysis 20040528

• Rosuvastatin and fenofibrate alone and in combination in type 2 diabetes patients with combined hyperlipidaemia.

  Diabetes research and clinical practice 20040501

• The effect of gemfibrozil on the pharmacokinetics of rosuvastatin.

  Clinical pharmacology and therapeutics 20040501

• Rosuvastatin reduces MMP-7 secretion by human monocyte-derived macrophages: potential relevance to atherosclerotic plaque stability.

  Atherosclerosis 20040501

• Investigating cardiovascular risk reduction--the Rosuvastatin GALAXY Programme.

  Expert opinion on pharmacotherapy 20040501

• Treatment and prevention of dyslipidemia with rosuvastatin (Crestor).

  The Nurse practitioner 20040501

• Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin in subclinical atherosclerosis--the rationale and methodology of the METEOR study.

  Cardiovascular drugs and therapy 20040501

• Effects of switching statins on achievement of lipid goals: Measuring Effective Reductions in Cholesterol Using Rosuvastatin Therapy (MERCURY I) study.

  American heart journal 20040401

• Two more drugs for dyslipidemia.

  The American journal of cardiology 20040315

• Rosuvastatin-warfarin drug interaction.

  Lancet (London, England) 20040313

• Pressure group urges rosuvastatin recall.

  Lancet (London, England) 20040313

• The effect of rosuvastatin on oestrogen & progestin pharmacokinetics in healthy women taking an oral contraceptive.

  British journal of clinical pharmacology 20040301

• Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia.

  Coronary artery disease 20040301

• More Western hypercholesterolemic patients achieve Japan Atherosclerosis Society LDL-C goals with rosuvastatin therapy than with atorvastatin, pravastatin, or simvastatin therapy.

  Circulation journal : official journal of the Japanese Circulation Society 20040201

• Rosuvastatin-warfarin drug interaction.

  Lancet (London, England) 20040124

• Is there a 'best' statin drug?

  The Johns Hopkins medical letter health after 50 20040101

• [Drug of the month. Rosuvastatin (Crestor)].

  Revue medicale de Liege 20040101

• Rosuvastatin: a review of its use in the management of dyslipidemia.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101

• Rosuvastatin-induced arrest in progression of renal disease.

  Cardiology 20040101

• New developments in pharmacotherapy.

  Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20040101

• Approximate equivalent rosuvastatin doses for temporary statin interchange programs.

  The Annals of pharmacotherapy 20040101

• Comparative evaluation of the efficacy, safety, and tolerability of rosuvastatin 10 mg with atorvastatin 10 mg in adult patients with hypercholesterolaemia: the first Indian study.

  Journal of the Indian Medical Association 20040101

• Clinical efficacy and safety of rosuvastatin in Japanese patients with heterozygous familial hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20040101

• Rosuvastatin alone or with extended-release niacin: a new therapeutic option for patients with combined hyperlipidemia.

  Preventive cardiology 20040101

• Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndrome.

  American journal of nephrology 20040101

• 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20031203

• Comparison of rosuvastatin versus atorvastatin in patients with heterozygous familial hypercholesterolemia.

  The American journal of cardiology 20031201

• Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia.

  Atherosclerosis 20031201

• [Diabetes and multimetabolic syndrome].

  Italian heart journal : official journal of the Italian Federation of Cardiology 20031201

• [Rosuvastatin: pharmacologic features].

  Italian heart journal : official journal of the Italian Federation of Cardiology 20031201

• [Clinical trials with rosuvastatin: efficacy and safety of its use].

  Italian heart journal : official journal of the Italian Federation of Cardiology 20031201

• [Ongoing trials and future prospects].

  Italian heart journal : official journal of the Italian Federation of Cardiology 20031201

• The statin wars.

  Lancet (London, England) 20031129

• The stain wars.

  Lancet (London, England) 20031129

• The stain wars.

  Lancet (London, England) 20031129

• The stain wars.

  Lancet (London, England) 20031129

• The stain wars.

  Lancet (London, England) 20031129

• Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial.

  Circulation 20031111

• Newer pharmaceutical agents to treat lipid disorders.

  Current cardiology reports 20031101

• The statin wars.

  Lancet (London, England) 20031101

• The cost-effectiveness of a new statin (rosuvastatin) in the UK NHS.

  International journal of clinical practice 20031101

• Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers.

  Clinical therapeutics 20031101

• Rosuvastatin: a new inhibitor of HMG-coA reductase for the treatment of dyslipidemia.

  Expert review of cardiovascular therapy 20031101

• Avoid the risks of mixed medications. How to minimize dangerous interactions with cardiovascular drugs.

  Heart advisor 20031101

• The statin wars: why AstraZeneca must retreat.

  Lancet (London, England) 20031025

• Rosuvastatin--a new lipid-lowering drug.

  The Medical letter on drugs and therapeutics 20031013

• New drugs and dosage forms.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031001

• Rosuvastatin calcium.

  Nature reviews. Drug discovery 20031001

• Statins: how far have we come? A review of rosuvastatin.

  International journal of clinical practice. Supplement 20031001

• Absolute oral bioavailability of rosuvastatin in healthy white adult male volunteers.

  Clinical therapeutics 20031001

• Cholesterol medication makes a debut in the U.S.

  Heart advisor 20031001

• Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models.

  Journal of the American College of Cardiology 20030917

• Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin.

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  Diabetes 20030901

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  The American journal of cardiology 20030821

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  The American journal of cardiology 20030715

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  Diabetes research and clinical practice 20030701

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  Diabetes research and clinical practice 20030701

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  The American journal of cardiology 20030601

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  Biochemical Society transactions 20030601

• Comparison of the dose-response relationships of 2 lipid-lowering agents: a Bayesian meta-analysis.

  American heart journal 20030601

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• An open-label, randomized, three-way crossover trial of the effects of coadministration of rosuvastatin and fenofibrate on the pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteers.

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  The American journal of cardiology 20030101

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  British journal of clinical pharmacology 20030101

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  Current medical research and opinion 20030101

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  Clinical cardiology 20010801

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  British journal of pharmacology 20010601

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