288-14-2 | Isoxazole

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$7.00	$5.00

Description

• Catalog Number: AB35284
• Chemical Name: Isoxazole
• CAS Number: 288-14-2
• Molecular Formula: C3H3NO
• Molecular Weight: 69.0620
• MDL Number: MFCD00003149
• SMILES: c1ccno1
• NSC Number: 137774

Computed Properties

• Complexity: 30.1
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 5
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 0.1

Literature

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  International journal of pharmaceutics 20120510

• Synthesis of 3,5-disubstituted isoxazoles via Cope-type hydroamination of 1,3-dialkynes.

  Organic letters 20120504

• Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

  Arthritis and rheumatism 20120501

• Experimental study of leflunomide on renal protective effect and on inflammatory response of streptozotocin induced diabetic rats.

  Nephrology (Carlton, Vic.) 20120501

• Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with leflunomide.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120501

• Combination of citalopram plus paliperidone is better than citalopram alone in the treatment of somatoform disorder: results of a 6-week randomized study.

  International clinical psychopharmacology 20120501

• A randomized, placebo- and active-controlled study of paliperidone extended-release as maintenance treatment in patients with bipolar I disorder after an acute manic or mixed episode.

  Journal of affective disorders 20120501

• Short-term effect of leflunomide in patients with Takayasu arteritis: an observational study.

  Scandinavian journal of rheumatology 20120501

• Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150,000 pregnant women and expectant fathers.

  Scandinavian journal of rheumatology 20120501

• Novel isoxazole polycyclic aromatic hydrocarbons as DNA-intercalating agents.

  European journal of medicinal chemistry 20120501

• Treatment of BK viremia in a pediatric heart transplant recipient.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120501

• Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.

  Acta anaesthesiologica Scandinavica 20120501

• Development of a population pharmacokinetic model for parecoxib and its active metabolite valdecoxib after parenteral parecoxib administration in children.

  Anesthesiology 20120501

• Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2.

  Bioorganic & medicinal chemistry 20120501

• Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.

  Bioorganic & medicinal chemistry 20120501

• Trade-offs in defensive metabolite production but not ecological function in healthy and diseased sponges.

  Journal of chemical ecology 20120501

• Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.

  Bioorganic & medicinal chemistry letters 20120501

• Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production.

  Bioorganic & medicinal chemistry 20120501

• Different safety profiles of risperidone and paliperidone extended-release: a double-blind, placebo-controlled trial with healthy volunteers.

  Human psychopharmacology 20120501

• 5-Methyl-N-[2-(trifluoro-meth-yl)phen-yl]isoxazole-4-carboxamide.

  Acta crystallographica. Section E, Structure reports online 20120501

• The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells.

  Oncotarget 20120501

• Immunotherapies in rheumatologic disorders.

  The Medical clinics of North America 20120501

• Identification of imine or enamine drug metabolites using online hydrogen/deuterium exchange and exact mass measurements.

  Rapid communications in mass spectrometry : RCM 20120430

• Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120425

• Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons.

  Neuroscience 20120419

• [Sulphasalazine in patients with rheumatoid arthritis in China: a cross-sectional study].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20120418

• Effects of zonisamide on tardive dyskinesia: a preliminary open-label trial.

  Journal of the neurological sciences 20120415

• Case report: Multidrug-resistant cytomegalovirus in a modified multivisceral transplant recipient.

  Transplantation 20120415

• Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption.

  Journal of medicinal chemistry 20120412

• GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120411

• High-performance liquid chromatographic enantioseparation of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on macrocyclic glycopeptide-based chiral stationary phases.

  Journal of chromatography. A 20120406

• Disseminated cutaneous and visceral Kaposi sarcoma in a woman with rheumatoid arthritis receiving leflunomide.

  Rheumatology international 20120401

• Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse.

  Journal of psychopharmacology (Oxford, England) 20120401

• Effect of cytochrome P450 3A4 inhibitor ketoconazole on risperidone pharmacokinetics in healthy volunteers.

  Journal of clinical pharmacy and therapeutics 20120401

• Pharmacokinetics and pharmacodynamics of A77 1726 and leflunomide in domestic cats.

  Journal of veterinary pharmacology and therapeutics 20120401

• Leflunomide in dermatology.

  Journal of the American Academy of Dermatology 20120401

• Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer.

  Lung cancer (Amsterdam, Netherlands) 20120401

• Lack of association between CAG repeat polymorphism in the androgen receptor gene and the outcome of rheumatoid arthritis treatment with leflunomide.

  European journal of clinical pharmacology 20120401

• Leflunomide for cytomegalovirus: bench to bedside.

  Transplant infectious disease : an official journal of the Transplantation Society 20120401

• Relationship between dose, drug levels, and D2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone.

  The Journal of pharmacology and experimental therapeutics 20120401

• Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients.

  Seizure 20120401

• Diarylheterocycle core ring features effect in selective COX-1 inhibition.

  ChemMedChem 20120401

• Variability of retention process of isoxaflutole and its diketonitrile metabolite in soil under conventional and conservation tillage.

  Pest management science 20120401

• Synthesis and biological activities of novel isoxazoline-linked pseudodisaccharide derivatives.

  Carbohydrate research 20120401

• Practical guidelines on the use of paliperidone palmitate in schizophrenia.

  Current medical research and opinion 20120401

• Transfer of parecoxib and its primary active metabolite valdecoxib via transitional breastmilk following intravenous parecoxib use after cesarean delivery: a comparison of naive pooled data analysis and nonlinear mixed-effects modeling.

  Anesthesia and analgesia 20120401

• Synthesis of heterocyclic N-(β-D-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase.

  Carbohydrate research 20120401

• A randomized, placebo-controlled study of zonisamide to prevent olanzapine-associated weight gain.

  Journal of clinical psychopharmacology 20120401

• Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides.

  European journal of medicinal chemistry 20120401

• Predicting plasma concentration of risperidone associated with dosage change: a population pharmacokinetic study.

  Therapeutic drug monitoring 20120401

• Design, synthesis, in vitro antimicrobial and anticancer activity of novel methylenebis-isoxazolo[4,5-b]azepines derivatives.

  European journal of medicinal chemistry 20120401

• Catatonia and encephalopathy associated with paliperidone palmitate.

  Journal of clinical psychopharmacology 20120401

• Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.

  Bioorganic & medicinal chemistry 20120401

• Impact of antiepileptic drugs on genesis of psychosis.

  Epilepsy & behavior : E&B 20120401

• A stability-indicating ultra-performance liquid chromatographic method for estimation of related substances and degradants in paliperidone active pharmaceutical ingredient and its pharmaceutical dosage forms.

  Journal of chromatographic science 20120401

• Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients.

  Epilepsy & behavior : E&B 20120401

• Iloperidone for the treatment of schizophrenia: an updated clinical review.

  Clinical schizophrenia & related psychoses 20120401

• Development and validation of an improved algorithm for overlaying flexible molecules.

  Journal of computer-aided molecular design 20120401

• (E)-Benzaldehyde O-{[3-(pyridin-3-yl)isoxazol-5-yl]meth-yl}oxime.

  Acta crystallographica. Section E, Structure reports online 20120401

• Ethyl 5-(4-amino-phen-yl)isoxazole-3-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20120401

• Synthesis and antimicrobial activity of N'-heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-adamantyl)-4-acetyl-5-[5-(4-substituted phenyl-3-isoxazolyl)]-1,3,4-oxadiazolines.

  Molecules (Basel, Switzerland) 20120316

• Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.

  Brain research 20120314

• Intracellular chloride concentration influences the GABAA receptor subunit composition.

  Nature communications 20120313

• Efficient synthesis of C2v-symmetrical pentakisadducts of C60 as versatile building blocks for fullerene architectures that involve a mixed octahedral addition pattern.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120312

• Stereoselective synthesis of 1-nitrobicyclo[3.1.0]hexanes and fused isoxazoline-N-oxides from primary nitro compounds.

  The Journal of organic chemistry 20120302

• Synthesis of benzisoxazolines by the coupling of arynes with nitrones.

  The Journal of organic chemistry 20120302

• Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice.

  Rheumatology international 20120301

• Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients.

  Rheumatology international 20120301

• [Stimulant and non-stimulant medication in current and future therapy for ADHD].

  Fortschritte der Neurologie-Psychiatrie 20120301

• Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

  British journal of pharmacology 20120301

• Analysis of gene variants previously associated with iloperidone response in patients with schizophrenia who are treated with risperidone.

  The Journal of clinical psychiatry 20120301

• HRD1 levels increased by zonisamide prevented cell death and caspase-3 activation caused by endoplasmic reticulum stress in SH-SY5Y cells.

  Journal of molecular neuroscience : MN 20120301

• D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.

  British journal of pharmacology 20120301

• Effectiveness of disease-modifying antirheumatic drug co-therapy with methotrexate and leflunomide in rituximab-treated rheumatoid arthritis patients: results of a 1-year follow-up study from the CERERRA collaboration.

  Annals of the rheumatic diseases 20120301

• Synthesis and antimicrobial evaluation of some new cyclooctanones and cyclooctane-based heterocycles.

  Archiv der Pharmazie 20120301

• On the mode of action of the herbicides cinmethylin and 5-benzyloxymethyl-1, 2-isoxazolines: putative inhibitors of plant tyrosine aminotransferase.

  Pest management science 20120301

• EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.

  American journal of physiology. Gastrointestinal and liver physiology 20120301

• Effects of general anaesthetics on 5-HT neuronal activity in the dorsal raphe nucleus.

  Neuropharmacology 20120301

• New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.

  European journal of medicinal chemistry 20120301

• Comparative bioequivalence study of leflunomide tablets in Indian healthy volunteers.

  Arzneimittel-Forschung 20120301

• Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20120301

• Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?

  Journal of cardiovascular pharmacology 20120301

• Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database.

  PLoS medicine 20120301

• Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.

  Molecules and cells 20120227

• Synthetic studies directed toward dideoxy lomaiviticinone lead to unexpected 1,2-oxazepine and isoxazole formation.

  Organic letters 20120217

• Expedient synthesis of a 72-membered isoxazolino-β-ketoamide library by a 2·3-component reaction.

  ACS combinatorial science 20120213

• Acid-base-catalysed condensation reaction in water: isoxazolines and isoxazoles from nitroacetates and dipolarophiles.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120213

• Falsely decreased ionized calcium results due to analytical interference by teriflunomide, the active metabolite of leflunomide (Arava®).

  Clinical chemistry and laboratory medicine 20120210

• Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

  Journal of medicinal chemistry 20120209

• Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study.

  The Journal of clinical psychiatry 20120201

• Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β.

  Neurochemical research 20120201

• Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice.

  International journal of oncology 20120201

• Clinical pharmacology of paliperidone palmitate a parenteral long-acting formulation for the treatment of schizophrenia.

  Reviews on recent clinical trials 20120201

• An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.

  Human molecular genetics 20120201

• Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors.

  Journal of neurophysiology 20120201

• Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks.

  World neurosurgery 20120201

• Synthesis and evaluation of hexahydropyrrolo[3,4-d]isoxazole-4,6-diones as anti-stress agents.

  European journal of medicinal chemistry 20120201

• Acute renal failure after paliperidone overdose: a case report.

  Journal of clinical psychopharmacology 20120201

• Parkinsonism and rabbit syndrome after discontinuation of low-dose ziprasidone and concomitant initiation of sertraline.

  Journal of clinical psychopharmacology 20120201

• Fixed drug eruption caused by etoricoxib with tolerance to celecoxib and parecoxib.

  Contact dermatitis 20120201

• [ Bone and cartilage destruction in RA and its intervention. Disease-modifying antirheumatic drugs].

  Clinical calcium 20120201

• A change from risperidone long acting injection to paliperidone palmitate in an elderly patient--a cautionary tale.

  The Australian and New Zealand journal of psychiatry 20120201

• (2S,5S,6R)-5-(4-Methyl-phen-yl)-3-phenyl-4,8-dioxa-3-aza-tricyclo-[7.4.0.0]trideca-1(13),9,11-triene-6-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20120201

• 4-Hy-droxy-3,5-dimeth-oxy-N-{4-[(5-methyl-1,2-oxazol-3-yl)sulfamo-yl]phen-yl}benzamide methanol monosolvate.

  Acta crystallographica. Section E, Structure reports online 20120201

• [Off-label therapy of rheumatoid arthritis and spondyloarthritis].

  Zeitschrift fur Rheumatologie 20120201

• Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides.

  Journal of medicinal chemistry 20120126

• Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.

  Journal of medicinal chemistry 20120126

• Regioselective synthesis of 3-arylamino- and 5-arylaminoisoxazoles from enaminones.

  Organic letters 20120120

• Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation.

  American journal of physiology. Lung cellular and molecular physiology 20120115

• Leflunomide induces apoptosis in fludarabine-resistant and clinically refractory CLL cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120115

• A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.

  Toxicology and applied pharmacology 20120115

• Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles.

  Organic & biomolecular chemistry 20120114

• Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.

  Journal of medicinal chemistry 20120112

• Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells.

  Progress in neuro-psychopharmacology & biological psychiatry 20120110

• Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.

  ACS combinatorial science 20120109

• A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

  The Journal of biological chemistry 20120106

• Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.

  Cell metabolism 20120104

• Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120102

• Evaluation of the efficacy and safety of paliperidone extended-release in the treatment of acute mania: a randomized, double-blind, dose-response study.

  Journal of affective disorders 20120101

• Leflunomide use in a cytomegalovirus infection of a patient with dermatomyositis.

  Rheumatology international 20120101

• Tissue biochemical alterations of Cyprinus carpio exposed to commercial herbicide containing clomazone under rice-field conditions.

  Archives of environmental contamination and toxicology 20120101

• Dramatic response to zonisamide of post-subarachnoid hemorrhage Holmes' tremor.

  Journal of neurology 20120101

• Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation.

  Cell research 20120101

• Efficacy of leflunomide addition in relation to prognostic factors for patients with active early rheumatoid arthritis failing to methotrexate in daily practice.

  Clinical rheumatology 20120101

• Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.

  American journal of physiology. Endocrinology and metabolism 20120101

• Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension.

  Chest 20120101

• Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines.

  Chemical biology & drug design 20120101

• The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120101

• Riluzole elevates GLT-1 activity and levels in striatal astrocytes.

  Neurochemistry international 20120101

• Short stay and less pain after ambulatory anterior cruciate ligament (ACL) repair: COX-2 inhibitor versus glucocorticoid versus both combined.

  Acta anaesthesiologica Scandinavica 20120101

• Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles.

  European journal of medicinal chemistry 20120101

• Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug.

  European journal of medicinal chemistry 20120101

• Design and diversity-oriented synthesis of novel 1,4-thiazepan-3-ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities.

  Bioorganic & medicinal chemistry letters 20120101

• QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.

  Human psychopharmacology 20120101

• Synthesis and in vitro and in vivo anticancer activity of novel phenylmethylene bis-isoxazolo[4,5-b]azepines.

  Bioorganic & medicinal chemistry letters 20120101

• Oral-paliperidone-induced tardive dyskinesia: a case report.

  General hospital psychiatry 20120101

• Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials.

  Human psychopharmacology 20120101

• Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents.

  Bioorganic & medicinal chemistry 20120101

• Anaphylactoid reaction to paliperidone palmitate extended-release injectable suspension in a patient tolerant of oral risperidone.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120101

• Effects of paliperidone extended release on the symptoms and functioning of schizophrenia.

  BMC clinical pharmacology 20120101

• Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1.

  Journal of translational medicine 20120101

• AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish.

  PloS one 20120101

• Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide.

  Handbook of experimental pharmacology 20120101

• Diaqua-bis-(5-methyl-1,2-oxazole-3-car-box-yl-ato-κN,O)cobalt(II) dihydrate.

  Acta crystallographica. Section E, Structure reports online 20120101

• Derivatives of 3-isoxazolecarboxylic acid esters: a potent and selective compound class against replicating and nonreplicating Mycobacterium tuberculosis.

  Current topics in medicinal chemistry 20120101

• An effective technique for salvage of cardiac-related devices.

  Eplasty 20120101

• Ritonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent manner.

  Antiviral therapy 20120101

• Alopecia areata during treatment of psoriasis with adalimumab and leflunomide: a case and review of the literature.

  Skin pharmacology and physiology 20120101

• The threshold rate of oral atypical anti-psychotic adherence at which paliperidone palmitate is cost saving.

  Journal of medical economics 20120101

• Interstitial lung disease related to rheumatoid arthritis: evolution after treatment.

  Reumatologia clinica 20120101

• Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1α.

  PloS one 20120101

• Leflunomide in monotherapy of rheumatoid arthritis: meta-analysis of randomized trials.

  Polskie Archiwum Medycyny Wewnetrznej 20120101

• [Efficacy, tolerability and safety of paliperidone extended-release in the treatment of schizophrenia and schizoaffective disorder].

  Rivista di psichiatria 20120101

• Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells.

  PloS one 20120101

• Cytotoxic effects of chemotherapeutic drugs and heterocyclic compounds at application on the cells of primary culture of neuroepithelium tumors.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20120101

• In situ nondestructive sediment characterization and resuspendability evaluation of concentrated aqueous paliperidone palmitate suspensions in prefilled syringes by low-field one-dimensional pulsed-field gradient NMR profilometry.

  Pharmaceutical development and technology 20120101

• α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.

  Advances in experimental medicine and biology 20120101

• A one-year prospective study of the safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate in patients with schizophrenia.

  BMC psychiatry 20120101

• Cost effectiveness of paliperidone palmitate versus risperidone long-acting injectable and olanzapine pamoate for the treatment of patients with schizophrenia in Sweden.

  Journal of medical economics 20120101

• The reactivity of gem cyanoester ketene dithiolates towards the development of potent antioxidant heterocycles.

  Chemical & pharmaceutical bulletin 20120101

• Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596.

  PloS one 20120101

• The HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damage.

  PloS one 20120101

• Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.

  PloS one 20120101

• Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.

  Journal of Alzheimer's disease : JAD 20120101

• The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes.

  PloS one 20120101

• On-farm bioremediation of dimethazone and trifluralin residues in runoff water from an agricultural field.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20120101

• Application of 2-trichloromethylbenzimidazole in analytical chemistry: a highly selective chromogenic reagent for thin-layer chromatography and some other analytical uses.

  Journal of analytical methods in chemistry 20120101

• [Another discussion of membrane voltage alterations in growing pollen tube].

  Tsitologiia 20120101

• Gastrointestinal stromal tumors: a review of case reports, diagnosis, treatment, and future directions.

  ISRN gastroenterology 20120101

• Docking studies, synthesis, characterization and evaluation of their antioxidant and cytotoxic activities of some novel isoxazole-substituted 9-anilinoacridine derivatives.

  TheScientificWorldJournal 20120101

• Ultraviolet C irradiation induces different expression of cyclooxygenase 2 in NIH 3T3 cells and A431 cells: the roles of COX-2 are different in various cell lines.

  International journal of molecular sciences 20120101

• The nicotinic acetylcholine receptor as a target for antidepressant drug development.

  TheScientificWorldJournal 20120101

• The chemoselective reduction of isoxazoline γ-lactams through iminium Aza-Diels-Alder reactions: a short-cut synthesis of aminols as valuable intermediates towards nucleoside derivatives.

  TheScientificWorldJournal 20120101

• Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo.

  PloS one 20120101

• Inhibition of ion channels and heart beat in Drosophila by selective COX-2 inhibitor SC-791.

  PloS one 20120101

• [Possibilities of the treatment of exacerbations of schizophrenia with the long acting atypical antipsychotic paliperidone palmitate].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101

• Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate.

  PloS one 20120101

• Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients.

  Human psychopharmacology 20120101

• Efficacy of leflunomide 100mg weekly compared to low dose methotrexate in patients with active rheumatoid arthritis. Double blind, randomized clinical trial.

  Reumatologia clinica 20120101

• Preemptive analgesic efficacy of parecoxib vs placebo in infertile women undergoing diagnostic laparoscopy: randomized controlled trial.

  Journal of minimally invasive gynecology 20120101

• Angioedema occurring in patient prescribed iloperidone and haloperidol: a cross-sensitivity reaction to antipsychotics from different chemical classes.

  The Journal of neuropsychiatry and clinical neurosciences 20120101

• A randomized, double-blind, controlled trial on non-opioid analgesics and opioid consumption for postoperative pain relief after laparoscopic cholecystectomy.

  Acta anaesthesiologica Belgica 20120101

• Exacerbation of AIH in a patient with an AIH/systemic sclerosis overlap syndrome and pulmonary arterial hypertension treated with the endothelin-1 receptor antagonist sitaxentan.

  BMJ case reports 20120101

• Iontophoresis of endothelin receptor antagonists in rats and men.

  PloS one 20120101

• The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.

  PloS one 20120101

• A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation.

  BMC nephrology 20120101

• Treatment with paliperidone in children with behavior disorders previously treated with risperidone: an open-label trial.

  Clinical neuropharmacology 20120101

• Immunosuppressive treatment for nephrotic idiopathic membranous nephropathy: a meta-analysis based on Chinese adults.

  PloS one 20120101

• Similarities between exogenously- and endogenously-induced envelope stress: the effects of a new antibacterial molecule, TPI1609-10.

  PloS one 20120101

• Aripiprazole reverses paliperidone-induced hyperprolactinemia.

  Actas espanolas de psiquiatria 20120101

• Zonisamide: its pharmacology, efficacy and safety in clinical trials.

  Acta neurologica Scandinavica. Supplementum 20120101

• Zonisamide in clinical practice.

  Acta neurologica Scandinavica. Supplementum 20120101

• A DFT study of pyrrole-isoxazole derivatives as chemosensors for fluoride anion.

  International journal of molecular sciences 20120101

• Adsorption mechanisms of isoxazole and oxazole on Si(100)-2 × 1 surface: Si-N dative bond addition vs. [4+2] cycloaddition.

  The Journal of chemical physics 20111228

• Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90.

  Journal of medicinal chemistry 20111222

• Regioselective synthesis and slow-release Suzuki-Miyaura cross-coupling of MIDA boronate-functionalized isoxazoles and triazoles.

  The Journal of organic chemistry 20111216

• A randomized, double-blind study of paliperidone extended-release in treatment of acute schizophrenia in adolescents.

  Biological psychiatry 20111215

• Use of comprehensive screening methods to detect selective human CAR activators.

  Biochemical pharmacology 20111215

• Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent.

  Bioorganic & medicinal chemistry 20111215

• Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands.

  ChemMedChem 20111209

• Development and validation of an analytical method based on high performance thin layer chromatography for the simultaneous determination of lamotrigine, zonisamide and levetiracetam in human plasma.

  Journal of pharmaceutical and biomedical analysis 20111205

• Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on.

  The journal of sexual medicine 20111201

• Cutaneous lupus erythematosus: update of therapeutic options part II.

  Journal of the American Academy of Dermatology 20111201

• Social interaction and drug attitude effectiveness in patients with schizophrenia.

  The Psychiatric quarterly 20111201

• The neurological safety of epidural parecoxib in rats.

  Neurotoxicology 20111201

• Zonisamide produces weight loss in psychotropic drug-treated psychiatric outpatients.

  Progress in neuro-psychopharmacology & biological psychiatry 20111201

• Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.

  Neuropharmacology 20111201

• Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cells.

  Journal of clinical immunology 20111201

• Comparative effectiveness of rituximab in combination with either methotrexate or leflunomide in the treatment of rheumatoid arthritis.

  Seminars in arthritis and rheumatism 20111201

• Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.

  Molecular pharmacology 20111201

• Gastric epithelial cell death caused by Helicobacter suis and Helicobacter pylori γ-glutamyl transpeptidase is mainly glutathione degradation-dependent.

  Cellular microbiology 20111201

• Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20111201

• Leflunomide pharmacokinetics after single oral administration to dogs.

  Journal of veterinary pharmacology and therapeutics 20111201

• New spirocyclic Δ²-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors.

  European journal of medicinal chemistry 20111201

• [Maintainance treatment of anti-neutrophil cytoplasm associated antibodies (ANCA)].

  Reumatologia clinica 20111201

• Patients with eating disorders (ED) treated with Zonisamide.

  Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20111201

• N-(2,6-Dichloro-phen-yl)-5-methyl-1,2-oxazole-4-carboxamide monohydrate.

  Acta crystallographica. Section E, Structure reports online 20111201

• N-(4-Chloro-2-nitro-phen-yl)-5-methyl-isoxazole-4-carboxamide.

  Acta crystallographica. Section E, Structure reports online 20111201

• The pyrolysis of isoxazole revisited: a new primary product and the pivotal role of the vinylnitrene. A low-temperature matrix isolation and computational study.

  Journal of the American Chemical Society 20111123

• Inhibiting effects of Leflunomide metabolite on overexpression of CD147, MMP-2 and MMP-9 in PMA differentiated THP-1 cells.

  European journal of pharmacology 20111116

• Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors.

  Journal of medicinal chemistry 20111110

• Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

  Nature chemical biology 20111106

• Chameleonic reactivity of vicinal diazonium salt of acetylenyl-9,10-anthraquinones: synthetic application toward two heterocyclic targets.

  The Journal of organic chemistry 20111104

• Effectiveness and safety of leflunomide for pulmonary and extrapulmonary sarcoidosis.

  The European respiratory journal 20111101

• Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells.

  American journal of respiratory cell and molecular biology 20111101

• Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol.

  Alcoholism, clinical and experimental research 20111101

• Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy.

  The Journal of veterinary medical science 20111101

• A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide.

  Neurobiology of disease 20111101

• Acidic residue modifications restore chaperone activity of β-casein interacting with lysozyme.

  International journal of biological macromolecules 20111101

• In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods.

  Antimicrobial agents and chemotherapy 20111101

• Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods.

  The Journal of antimicrobial chemotherapy 20111101

• Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3.

  Stem cells (Dayton, Ohio) 20111101

• Zonisamide in the treatment of epilepsy.

  Expert opinion on pharmacotherapy 20111101

• Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C.

  Bioorganic & medicinal chemistry 20111101

• Triclosan, an environmental pollutant from health care products, evokes charybdotoxin-sensitive hyperpolarization in rat thymocytes.

  Environmental toxicology and pharmacology 20111101

• Formation of ionized arylamines upon electron ionization of N-aryl-methyl-isoxazole-4-carboxamides: correlation with Hammett's constants and arylamine pKb's mass spectra of arylmethylisoxazolecarboxamides.

  Journal of mass spectrometry : JMS 20111101

• 3-[Chloro-(phen-yl)meth-yl]-6-methyl-1,2-benzoxazole.

  Acta crystallographica. Section E, Structure reports online 20111101

• rac-Ethyl 6-hy-droxy-6-methyl-3-oxo-4-phenyl-1,3,4,5,6,7-hexa-hydro-benzo[c][1,2]oxazole-5-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20111101

• Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.

  Journal of medicinal chemistry 20111027

• N-heterocyclic carbene-catalyzed 1,3-dipolar cycloaddition reactions: a facile synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles.

  Organic & biomolecular chemistry 20111026

• [Systemic autoimmune disorders and pregnancy].

  Orvosi hetilap 20111023

• The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function.

  Biochemical pharmacology 20111015

• Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.

  Bioorganic & medicinal chemistry letters 20111015

• EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women.

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20111015

• 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.

  Journal of medicinal chemistry 20111013

• [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20111010

• Three-component coupling approach to trachyspic acid.

  Organic letters 20111007

• Catalytic asymmetric 1,6-Michael addition of arylthiols to 3-methyl-4-nitro-5-alkenyl-isoxazoles with bifunctional catalysts.

  The Journal of organic chemistry 20111007

• The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment.

  Pediatric nephrology (Berlin, Germany) 20111001

• Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death.

  Psychopharmacology 20111001

• A series of complications after third molar osteotomy in a pancytopenia patient and spontaneous healing after bone marrow transplantation.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20111001

• Effects of acute paliperidone palmitate treatment in subjects with schizophrenia recently treated with oral risperidone.

  Schizophrenia research 20111001

• Leflunomide with low-dose everolimus for treatment of Kaposi's sarcoma in a renal allograft recipient.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111001

• Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.

  Journal of neurophysiology 20111001

• Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.

  American journal of physiology. Lung cellular and molecular physiology 20111001

• In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds.

  Antimicrobial agents and chemotherapy 20111001

• Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.

  European journal of medicinal chemistry 20111001

• Comparing the influence of dopamine D₂ polymorphisms and plasma drug concentrations on the clinical response to risperidone.

  Journal of clinical psychopharmacology 20111001

• Enantioselective fungal biotransformation of risperidone in liquid culture medium by capillary electrophoresis and hollow fiber liquid-phase microextraction.

  Electrophoresis 20111001

• Dosing and switching strategies for paliperidone palmitate: based on population pharmacokinetic modelling and clinical trial data.

  CNS drugs 20111001

• Biological perspectives: update on newer antipsychotic drugs: are they evidence based?

  Perspectives in psychiatric care 20111001

• Leflunomide in clinical practice. A retrospective observational study on use of leflunomide in New Zealand.

  International journal of rheumatic diseases 20111001

• [Analgesic effect of COX inhibitors and its mechanism in a rat model of neuropathic pain].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111001

• Paliperidone palmitate in a child with autistic disorder.

  Journal of child and adolescent psychopharmacology 20111001

• 5-Methyl-1,2-oxazole-3-carb-oxy-lic acid.

  Acta crystallographica. Section E, Structure reports online 20111001

• DNA binding, antiviral activities and cytotoxicity of new furochromone and benzofuran derivatives.

  Archives of pharmacal research 20111001

• Changes in cotherapies after initiation of disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis.

  Arthritis care & research 20111001

• Pain control in laparoscopic gynecologic surgery with/without preoperative (preemptive) parecoxib sodium injection: a randomized study.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20111001

• [Inhibitory activity of dioxy-pyrrolino [3', 4'-d]isoxazoline derivatives containing (1', 2'-O-cyclohexylidendioxyethyl) against Cdc25A and CD45].

  Yao xue xue bao = Acta pharmaceutica Sinica 20111001

• Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression.

  Oncogene 20110929

• Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110928

• Application of Hansen solubility parameters for understanding and prediction of drug distribution in microspheres.

  International journal of pharmaceutics 20110915

• Multiresidue method for the determination of 13 pesticides in three environmental matrices: water, sediments and fish muscle.

  Talanta 20110915

• Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a.

  Bioorganic & medicinal chemistry letters 20110915

• Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery.

  ACS combinatorial science 20110912

• Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation.

  Journal of psychiatric research 20110901

• Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of risperidone in healthy subjects with CYP2D6*10/*10.

  British journal of pharmacology 20110901

• A role for macrophage migration inhibitory factor in protective immunity against Aspergillus fumigatus.

  Immunobiology 20110901

• Comparative trial of low- and high-dose zonisamide as monotherapy for childhood epilepsy.

  Seizure 20110901

• The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral centre.

  Epilepsy research 20110901

• Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse.

  Neurobiology of disease 20110901

• Investigation into the regiochemistry of some isoxazoles derived from 1,3-dipolar cycloaddition of 4-nitrobenzonitrile oxide with some dipolarophiles: a combined theoretical and experimental studies.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901

• Efficacy of iloperidone in schizophrenia: a PANSS five-factor analysis.

  Schizophrenia research 20110901

• Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation.

  Toxicological sciences : an official journal of the Society of Toxicology 20110901

• Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.

  Analytical and bioanalytical chemistry 20110901

• Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.

  European journal of medicinal chemistry 20110901

• Controversy of non-steroidal anti-inflammatory drugs and intracranial surgery: et ne nos inducas in tentationem?

  British journal of anaesthesia 20110901

• Effect of intravenous parecoxib on post-craniotomy pain.

  British journal of anaesthesia 20110901

• Quality of life in patients with partial-onset seizures under adjunctive therapy with zonisamide: results from a prospective non-interventional surveillance study.

  Epileptic disorders : international epilepsy journal with videotape 20110901

• Case of drug rash with eosinophilia and systemic symptoms induced by zonisamide and reactivation of human herpes virus 7.

  The Journal of dermatology 20110901

• Bis[N-cyclohexyl-1-(2-{1-[(cyclohexyl-amino)carbonyl]cyclohexyl}-3,5-dioxo-1,2-oxazolidin-4-yl)cyclopentanecarbox-amide] monohydrate.

  Acta crystallographica. Section E, Structure reports online 20110901

• 2-{Hy-droxy[1-(4-meth-oxy-phen-yl)-4-oxo-3-phenyl-azetidin-2-yl]meth-yl}acrylonitrile.

  Acta crystallographica. Section E, Structure reports online 20110901

• Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apc(min/+) mouse.

  British journal of cancer 20110823

• Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801.

  Neuroscience letters 20110818

• Synthesis of tri- or tetrasubstituted pyrimidine derivatives through the [5+1] annulation of enamidines with either N,N-dimethylformamide dialkyl acetals or orthoesters and their application in a ring transformation of pyrimidines to pyrido[2,3-d]pyrimidin-5-one derivatives.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110816

• Chemical and toxicological evolution of the antibiotic sulfamethoxazole under ozone treatment in water solution.

  Journal of hazardous materials 20110815

• Isoxazole substituted chromans against oxidative stress-induced neuronal damage.

  Bioorganic & medicinal chemistry 20110815

• Facile synthesis of carbohydrate-integrated isoxazolines through tandem [4+1] cycloaddition and rearrangement of 2-nitroglycals.

  Chemical communications (Cambridge, England) 20110814

• Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients.

  Modern rheumatology 20110801

• The interaction of antipsychotic drugs with lipids and subsequent lipid reorganization investigated using biophysical methods.

  Biochimica et biophysica acta 20110801

• Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.

  Toxicological sciences : an official journal of the Society of Toxicology 20110801

• Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β.

  Drug metabolism and disposition: the biological fate of chemicals 20110801

• Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK/RANKL.

  Acta biomaterialia 20110801

• Isoxazol-5(4H)one derivatives as PTP1B inhibitors showing an anti-obesity effect.

  Chemistry, an Asian journal 20110801

• Oxime-based click chemistry in the development of 3-isoxazolecarboxylic acid containing inhibitors of Yersinia pestis protein tyrosine phosphatase, YopH.

  ChemMedChem 20110801

• Changes in schizophrenia-related hospitalization and ER use among patients receiving paliperidone palmitate: results from a clinical trial with a 52-week open-label extension (OLE).

  Current medical research and opinion 20110801

• Antimycobacterial activity: synthesis of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues.

  Journal of enzyme inhibition and medicinal chemistry 20110801

• Direct electron transfer enhancement of covalently bound tyrosinase to glassy carbon via Woodward's reagent K.

  Bioelectrochemistry (Amsterdam, Netherlands) 20110801

• Osmotic-controlled release oral delivery system (OROS) paliperidone-related pruritic rash.

  Journal of clinical psychopharmacology 20110801

• Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.

  Bioorganic & medicinal chemistry letters 20110801

• Photodistributed eruption with rhabdomyolisis due to leflunomide.

  Photodermatology, photoimmunology & photomedicine 20110801

• A case of eczematous and vesicular dermatitis during anti-TNFalpha therapy for rheumatoid arthritis.

  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20110801

• 3,5-Bis(4-meth-oxy-phen-yl)-4,5-dihydro-isoxazole.

  Acta crystallographica. Section E, Structure reports online 20110801

• Methyl 3-(4-isopropyl-phen-yl)-1-phenyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20110801

• Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.

  The Journal of biological chemistry 20110729

• Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.

  Journal of medicinal chemistry 20110714

• Preconditioning of intravenous parecoxib attenuates focal cerebral ischemia/reperfusion injury in rats.

  Chinese medical journal 20110705

• Recurrent pneumothorax associated with pulmonary nodules after leflunomide therapy in rheumatoid arthritis: a case report and review of the literature.

  Rheumatology international 20110701

• Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effective.

  Rheumatology (Oxford, England) 20110701

• Paliperidone overdose with delayed onset of toxicity.

  Annals of emergency medicine 20110701

• Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury.

  Expert opinion on drug safety 20110701

• Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases.

  The British journal of dermatology 20110701

• Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.

  The Journal of pharmacology and experimental therapeutics 20110701

• Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins.

  Cancer science 20110701

• MultiSimplex optimization of chromatographic separation and dansyl derivatization conditions in the ultra performance liquid chromatography-tandem mass spectrometry analysis of risperidone, 9-hydroxyrisperidone, monoamine and amino acid neurotransmitters in human urine.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110701

• Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.

  Epilepsia 20110701

• Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.

  Bioorganic & medicinal chemistry letters 20110701

• Drug safety evaluation of zonisamide for the treatment of epilepsy.

  Expert opinion on drug safety 20110701

• 5-(3-Methyl-phen-yl)-3-phenyl-1,2-oxazole.

  Acta crystallographica. Section E, Structure reports online 20110701

• 1-Methyl-3-p-tolyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20110701

• 3'-(4-Meth-oxy-phen-yl)-4'-phenyl-3H,4'H-spiro-[1-benzothio-phene-2,5'-isoxazol]-3-one.

  Acta crystallographica. Section E, Structure reports online 20110701

• 4-tert-Butyl-3',4'-bis-(4-methyl-phen-yl)-3,4-dihydro-1H,4'H-spiro-[naphthalene-2,5'-[1,2]oxazol]-1-one.

  Acta crystallographica. Section E, Structure reports online 20110701

• Glutathione is a physiologic reservoir of neuronal glutamate.

  Biochemical and biophysical research communications 20110617

• Self-assembly and gelation behavior of tris(phenylisoxazolyl)benzenes.

  The Journal of organic chemistry 20110617

• Combined effects of novel heat shock protein 90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen.

  Oncogene 20110616

• Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles.

  Bioorganic & medicinal chemistry letters 20110615

• New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.

  Bioorganic & medicinal chemistry 20110615

• Base-catalyzed reactions of environmentally relevant N-chloro-piperidines. A quantum-chemical study.

  Organic & biomolecular chemistry 20110607

• Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas.

  Journal of neuro-oncology 20110601

• Intraoperative infusion of S(+)-ketamine enhances post-thoracotomy pain control compared with perioperative parecoxib when used in conjunction with thoracic paravertebral ropivacaine infusion.

  Journal of cardiothoracic and vascular anesthesia 20110601

• The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.

  Neuropharmacology 20110601

• Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex.

  Behavioural brain research 20110601

• Efficient in silico assay of inhibitors of hepatitis C Virus RNA-dependent RNA polymerase by structure-based virtual screening and in vitro evaluation.

  Assay and drug development technologies 20110601

• Effective treatment of Kimura's disease with leflunomide in combination with glucocorticoids.

  Clinical rheumatology 20110601

• Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20110601

• A comparative study of paliperidone palmitate and risperidone long-acting injectable therapy in schizophrenia.

  Progress in neuro-psychopharmacology & biological psychiatry 20110601

• Effects of intramuscular parecoxib administration on vasospasm in an experimental subarachnoid hemorrhage model.

  The International journal of neuroscience 20110601

• Prolongation of cardiac ventricular repolarization under paliperidone: how and how much?

  Journal of cardiovascular pharmacology 20110601

• Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.

  Pain 20110601

• Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice.

  Pain 20110601

• Risperidone in schizophrenia: is there a role for therapeutic drug monitoring?

  Therapeutic drug monitoring 20110601

• Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression.

  Schizophrenia research 20110601

• Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.

  Epilepsy research 20110601

• Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives.

  Bioorganic & medicinal chemistry letters 20110601

• Paliperidone-related rabbit syndrome.

  Journal of clinical psychopharmacology 20110601

• Use of paliperidone in elderly patients with schizophrenia and schizoaffective disorder: a prospective open-label short-term pilot study.

  Journal of clinical psychopharmacology 20110601

• Microbially mediated abiotic transformation of the antimicrobial agent sulfamethoxazole under iron-reducing soil conditions.

  Environmental science & technology 20110601

• Oral paliperidone: a review of its use in the management of schizoaffective disorder.

  CNS drugs 20110601

• [Pharmacological properties of paliperidone ER (INVEGA(®)) and results of its clinical studies].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110601

• [Recommendations on the management of psoriatic arthritis].

  Annales de dermatologie et de venereologie 20110601

• Poly[(μ(3)-rac-5-eth-oxy-carbonyl-6-hy-droxy-6-methyl-4-phenyl-4,5,6,7-tetra-hydro-benzo[c]isoxazol-3-olato)potassium].

  Acta crystallographica. Section E, Structure reports online 20110601

• 3-Allyl-1-{[3-(4-nitro-phen-yl)-4,5-dihydro-1,3-oxazol-5-yl]meth-yl}-1H-anthra[1,2-d]imidazole-2,6,11(3H)-trione.

  Acta crystallographica. Section E, Structure reports online 20110601

• Cascade formation of isoxazoles: facile base-mediated rearrangement of substituted oxetanes.

  Angewandte Chemie (International ed. in English) 20110527

• Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide.

  The Biochemical journal 20110515

• Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists.

  Bioorganic & medicinal chemistry 20110515

• Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group.

  Journal of agricultural and food chemistry 20110511

• Palladium-catalyzed cyanomethylation of aryl halides through domino Suzuki coupling-isoxazole fragmentation.

  Journal of the American Chemical Society 20110511

• Iodocyclization of hydroxylamine derivatives based on the control of oxidative aromatization leading to 2,5-dihydroisoxazoles and isoxazoles.

  The Journal of organic chemistry 20110506

• Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.

  ChemMedChem 20110502

• A 52-week open-label study of the safety and tolerability of paliperidone palmitate in patients with schizophrenia.

  Journal of psychopharmacology (Oxford, England) 20110501

• Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.

  Pharmacogenetics and genomics 20110501

• Design, synthesis and cytotoxicity of a new series of isoxazolidine based nucleoside analogues.

  Archiv der Pharmazie 20110501

• Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.

  Journal of thrombosis and thrombolysis 20110501

• Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms.

  Drug metabolism and disposition: the biological fate of chemicals 20110501

• Role of macrophage migration inhibitory factor in primary glioblastoma multiforme cells.

  Journal of neuroscience research 20110501

• Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011?

  Current opinion in rheumatology 20110501

• Pyrazolo[3,4-c]isothiazole and isothiazolo[4,3-d]isoxazole derivatives as antifungal agents.

  Pharmaceutical biology 20110501

• Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses.

  Current opinion in rheumatology 20110501

• Moderate toxic effects following acute zonisamide overdose.

  Epilepsy & behavior : E&B 20110501

• Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies.

  Nuclear medicine and biology 20110501

• Leflunomide in renal transplantation.

  Expert review of clinical immunology 20110501

• Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation.

  PLoS neglected tropical diseases 20110501

• (S)-[5-Methyl-3-(3-methyl-thio-phen-2-yl)-4,5-dihydro-isoxazol-5-yl]methanol.

  Acta crystallographica. Section E, Structure reports online 20110501

• [Isolation and identification of brominated alkaloids from the sponge Ircinia sp].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

• Ammonia channeling in Plasmodium falciparum GMP synthetase: investigation by NMR spectroscopy and biochemical assays.

  Biochemistry 20110426

• Catalytic asymmetric syntheses of isoxazoline-N-oxides under phase-transfer conditions.

  Chemical communications (Cambridge, England) 20110421

• Design, synthesis, and evaluation of small molecule Hsp90 probes.

  Bioorganic & medicinal chemistry 20110415

• Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity.

  Brain research 20110412

• Pseudo-pseudo Meigs syndrome developed under the leflunomide therapy.

  Rheumatology international 20110401

• Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.

  Hippocampus 20110401

• Zonisamide-related erectile dysfunction.

  The journal of sexual medicine 20110401

• A comparison of an interferon-gamma release assay and tuberculin skin test in refractory inflammatory disease patients screened for latent tuberculosis prior to the initiation of a first tumor necrosis factor α inhibitor.

  Clinical rheumatology 20110401

• Efficacy of zonisamide in a case of Parkinson's disease with intractable resting and re-emergent tremor.

  European journal of neurology 20110401

• Interstitial lung diseases after leflunomide use in nephropathy: an analysis of reported cases in Chinese literature.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110401

• Synthesis of some novel androstanes as potential aromatase inhibitors.

  Steroids 20110401

• Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade.

  Critical care medicine 20110401

• TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts.

  American journal of physiology. Gastrointestinal and liver physiology 20110401

• Determination of clomazone residues in soybean and soil by high performance liquid chromatography with DAD detection.

  Bulletin of environmental contamination and toxicology 20110401

• Design, synthesis and cytotoxicity of a new series of isoxazolidines derived from substituted chalcones.

  European journal of medicinal chemistry 20110401

• Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease.

  Hypertension (Dallas, Tex. : 1979) 20110401

• Paliperidone augmentation for treatment-resistant depression: a case report.

  Journal of clinical psychopharmacology 20110401

• Paliperidone-associated seizure after discontinuation of sodium valproate: a case report.

  Journal of clinical psychopharmacology 20110401

• Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.

  Differentiation; research in biological diversity 20110401

• Update on newer antipsychotic drugs.

  Journal of psychosocial nursing and mental health services 20110401

• Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan.

  Wiener klinische Wochenschrift 20110401

• Zonisamide toxicity in a patient with an intentional overdose.

  The Annals of pharmacotherapy 20110401

• Predictors of risperidone and 9-hydroxyrisperidone serum concentration in children and adolescents.

  Journal of child and adolescent psychopharmacology 20110401

• Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance.

  Transplantation proceedings 20110401

• Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.

  Anticancer research 20110401

• Risk of arrest in persons with schizophrenia and bipolar disorder in a Florida Medicaid program: the role of atypical antipsychotics, conventional neuroleptics, and routine outpatient behavioral health services.

  The Journal of clinical psychiatry 20110401

• 3-(3-Chloro-phen-yl)-1-methyl-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20110401

• 1-Methyl-3-(2-methyl-phen-yl)-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c][1,2]oxazole-3a-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20110401

• 1-Methyl-3-(naphthalen-1-yl)-3,3a,4,9b-tetra-hydro-1H-chromeno[4,3-c]isoxazole-3a-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20110401

• Paliperidone-associated atypical neuroleptic malignant syndrome: a case report.

  Progress in neuro-psychopharmacology & biological psychiatry 20110330

• Our clinical experience with zonisamide in resistant generalized epilepsy syndromes.

  Ideggyogyaszati szemle 20110330

• Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity.

  World journal of gastroenterology 20110328

• New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.

  Journal of natural products 20110325

• DHODH modulates transcriptional elongation in the neural crest and melanoma.

  Nature 20110324

• Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives.

  Chembiochem : a European journal of chemical biology 20110321

• [Inhibition of leflunomide active metabolite A771726 on high glucose-induced podocyte apoptosis].

  Zhonghua yi xue za zhi 20110315

• Synthesis and antimicrobial evaluation of some heterocyclic chalcone derivatives.

  Molecules (Basel, Switzerland) 20110309

• Rituximab and leflunomide for Wegener's granulomatosis: a long-term follow-up.

  Rheumatology international 20110301

• Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid β-ODAP (β-N-oxalyl-L-α,β-diaminopropionic acid) in callus tissue of Lathyrus sativus.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110301

• Paliperidone extended-release as adjunctive therapy to lithium or valproate in the treatment of acute mania: a randomized, placebo-controlled study.

  Journal of affective disorders 20110301

• Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.

  Psychopharmacology 20110301

• A case of SUNCT syndrome responsive to zonisamide.

  Cephalalgia : an international journal of headache 20110301

• Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens.

  Congenital anomalies 20110301

• Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.

  Hepatology (Baltimore, Md.) 20110301

• [Role of daptomycin in the empirical and directed therapy of infections caused by Gram-positive bacteria in the critically ill patient].

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20110301

• Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.

  Postgraduate medicine 20110301

• (E)-7-(4-Chloro-phen-yl)-5,7-dihydro-4H-pyrano[3,4-c]isoxazole-3-carbaldehyde oxime.

  Acta crystallographica. Section E, Structure reports online 20110301

• Iloperidone for the management of adults with schizophrenia.

  Clinical therapeutics 20110301

• Photochemistry and vibrational spectra of matrix-isolated methyl 4-chloro-5-phenylisoxazole-3-carboxylate.

  The journal of physical chemistry. A 20110224

• Heterogeneity of Escherichia coli population by respiratory activity and membrane potential of cells during growth and long-term starvation.

  Microbiological research 20110220

• Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.

  Bioorganic & medicinal chemistry letters 20110215

• Iloperidone: Does it have a meaningful place in therapy?

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110215

• Iloperidone: A new drug for the treatment of schizophrenia.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110215

• Zonisamide for bipolar disorder, mania or mixed states: a randomized, double blind, placebo-controlled adjunctive trial.

  Psychopharmacology bulletin 20110215

• Preparation and evaluation of biodegradable films containing the potent osteogenic compound BFB0261 for localized delivery.

  International journal of pharmaceutics 20110214

• Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)--A modelling approach to determine IC(50) values of the three ionic species of gaboxadol.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110214

• Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex.

  Journal of medicinal chemistry 20110210

• Excited-state intramolecular proton transfer in hydroxyoxime-based chemical sensors.

  The journal of physical chemistry. A 20110210

• Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry.

  Journal of medicinal chemistry 20110210

• Highly enantioselective nitrone cycloadditions with 2-alkenoyl pyridine N-oxides catalyzed by Cu(II)-BOX complexes.

  Organic letters 20110204

• Metal-free sequential [3 + 2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity.

  Journal of the American Chemical Society 20110202

• Jessner-Kanof disease induced by leflunomide: a dermal variant of cutaneous lupus?

  Rheumatology international 20110201

• A randomized controlled trial of valdecoxib and glyceryl trinitrate for the prevention of post-ERCP pancreatitis.

  Journal of clinical gastroenterology 20110201

• Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk.

  Breast (Edinburgh, Scotland) 20110201

• Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minor-to-intermediate surgery: a randomised, double-blind trial.

  European journal of anaesthesiology 20110201

• A pilot open-label trial of zonisamide in Unverricht-Lundborg disease.

  Movement disorders : official journal of the Movement Disorder Society 20110201

• Parecoxib sodium in the treatment of postoperative pain after Lichtenstein tension-free mesh inguinal hernia repair.

  Hernia : the journal of hernias and abdominal wall surgery 20110201

• Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level.

  European journal of clinical pharmacology 20110201

• Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.

  Drug metabolism and disposition: the biological fate of chemicals 20110201

• Are the long-acting intramuscular formulations of risperidone or paliperidone palmitate associated with post-injection delirium/sedation syndrome? An assessment of safety databases.

  Current drug safety 20110201

• Change in employment status over 52 weeks in patients with schizophrenia: an observational study.

  Current medical research and opinion 20110201

• Endothelin receptor antagonists as disease modifiers in systemic sclerosis.

  Inflammation & allergy drug targets 20110201

• Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents.

  European journal of medicinal chemistry 20110201

• Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility.

  European journal of medicinal chemistry 20110201

• Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor.

  Bioorganic & medicinal chemistry letters 20110201

• Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.

  European journal of medicinal chemistry 20110201

• Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists.

  Bioorganic & medicinal chemistry letters 20110201

• Prolapse gastropathy.

  Journal of pediatric gastroenterology and nutrition 20110201

• Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work.

  The Journal of dermatology 20110201

• Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension.

  The European respiratory journal 20110201

• Liver toxicity of sitaxentan in pulmonary arterial hypertension.

  The European respiratory journal 20110201

• Zonisamide for migraine prophylaxis in topiramate-intolerant patients: an observational study.

  Headache 20110201

• Effects of Cox inhibitors on bone and tendon healing.

  Acta orthopaedica. Supplementum 20110201

• Leflunomide in Pakistani patients with rheumatoid arthritis: prospective study in daily rheumatology practice.

  International journal of rheumatic diseases 20110201

• [Effects of parecoxib on morphine dosage in postoperative patient-controlled analgesia following thoracoscope-assisted thoracotomy].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110201

• A novel hypothesized clinical implication of zonisamide for autism.

  Annals of neurology 20110201

• Liver toxicity of sitaxentan in pulmonary arterial hypertension.

  European heart journal 20110201

• 1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one.

  Acta crystallographica. Section E, Structure reports online 20110201

• cis-6-Bromo-4-(1-methyl-1H-indol-3-yl)-10,10a-dihydro-1H,4H-2,9-dioxa-3-aza-benz[f]azulene.

  Acta crystallographica. Section E, Structure reports online 20110201

• Immunosuppressive therapy in children.

  Journal of the Indian Medical Association 20110201

• Dihydroisoxazole analogs for labeling and visualization of catalytically active transglutaminase 2.

  Chemistry & biology 20110128

• Synthesis of 4(5)-phenacyl-imidazoles from isoxazole side-chain rearrangements.

  Organic & biomolecular chemistry 20110121

• Synthesis of isoxazoline N-oxides via [hydroxy(tosyloxy)iodo]benzene (HTIB)-mediated oxidative N-O coupling.

  The Journal of organic chemistry 20110121

• Paliperidone-induced leukopenia and neutropenia: a case report.

  Progress in neuro-psychopharmacology & biological psychiatry 20110115

• A double-blind study of paliperidone palmitate and risperidone long-acting injectable in adults with schizophrenia.

  Progress in neuro-psychopharmacology & biological psychiatry 20110115

• Analysis of risperidone and 9-hydroxyrisperidone in human plasma, urine and saliva by MEPS-LC-UV.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115

• Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina.

  Bioorganic & medicinal chemistry letters 20110115

• Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

  Journal of medicinal chemistry 20110113

• Detection and evaluation of a drug safety signal concerning pancreatic cancer: lessons from a joint approach of three European biologics registers.

  Rheumatology (Oxford, England) 20110101

• Evaluation of the effect of paliperidone extended release and quetiapine on corrected QT intervals: a randomized, double-blind, placebo-controlled study.

  International clinical psychopharmacology 20110101

• Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators.

  Biopolymers 20110101

• A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.

  The Journal of pharmacology and experimental therapeutics 20110101

• GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.

  Current topics in medicinal chemistry 20110101

• Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue.

  Neurochemistry international 20110101

• A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.

  Journal of immunology (Baltimore, Md. : 1950) 20110101

• 1,2,5-Oxadiazole analogues of leflunomide and related compounds.

  European journal of medicinal chemistry 20110101

• Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation.

  Bioorganic & medicinal chemistry letters 20110101

• The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.

  Bioorganic & medicinal chemistry letters 20110101

• Efficacy and safety of adjunctive zonisamide in adult patients with refractory partial-onset epilepsy: a randomized, double-blind, placebo-controlled trial.

  Clinical drug investigation 20110101

• The effect of ESR1 and ESR2 gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide.

  Pharmacogenomics 20110101

• Mitigation of dimethazone residues in soil and runoff water from agricultural field.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20110101

• Atypical antipsychotics: the two new arrivals.

  Issues in mental health nursing 20110101

• Amygdalar glutamatergic neuronal systems play a key role on the hibernating state of hamsters.

  BMC neuroscience 20110101

• Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus.

  PloS one 20110101

• Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis.

  BMC psychiatry 20110101

• Paliperidone-induced neuroleptic malignant syndrome.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Identification and quantification of selected inflammatory genes modulated by leflunomide and prednisone treatment in early rheumatoid arthritis patients.

  Clinical and experimental rheumatology 20110101

• Cardiac safety of the electroconvulsive therapy-paliperidone combination: a preliminary study.

  General hospital psychiatry 20110101

• Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases.

  Arzneimittel-Forschung 20110101

• QSAR analysis of [(biphenyloxy)propyl]isoxazoles: agents against coxsackievirus B3.

  Future medicinal chemistry 20110101

• Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies.

  Beilstein journal of organic chemistry 20110101

• Paliperidone extended-release: does it have a place in antipsychotic therapy?

  Drug design, development and therapy 20110101

• Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension.

  Vascular health and risk management 20110101

• Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis.

  International journal of immunopathology and pharmacology 20110101

• Chemopreventive effect of mofezolac on beef tallow diet/azoxymethane-induced colon carcinogenesis in rats.

  Hepato-gastroenterology 20110101

• Adsorption of isoxaflutole degradates to aluminum and iron hydrous oxides.

  Journal of environmental quality 20110101

• 1-[2-(4-Nitro-phen-yl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetra-hydro-quinolin-4-yl]pyrrolidin-2-one monohydrate.

  Acta crystallographica. Section E, Structure reports online 20110101

• Inhibition of respiratory syncytial virus in vitro and in vivo by the immunosuppressive agent leflunomide.

  Antiviral therapy 20110101

• Acute dystonia associated with paliperidone overdose.

  Psychosomatics 20110101

• Onset of efficacy and tolerability following the initiation dosing of long-acting paliperidone palmitate: post-hoc analyses of a randomized, double-blind clinical trial.

  BMC psychiatry 20110101

• Liver toxicity is rare in rheumatoid arthritis patients using combination therapy with leflunomide and methotrexate.

  Revista brasileira de reumatologia 20110101

• Safety of parecoxib in asthmatic patients with aspirin-exacerbated respiratory disease.

  International archives of allergy and immunology 20110101

• Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.

  PloS one 20110101

• Soft tissue infections with atypical mycobacteria in two patients with inflammatory rheumatic diseases using TNF-inhibitors and/or leflunomide.

  Acta clinica Belgica 20110101

• Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues.

  Acta poloniae pharmaceutica 20110101

• Combined 3D-QSAR, molecular docking and molecular dynamics study on derivatives of peptide epoxyketone and tyropeptin-boronic acid as inhibitors against the β5 subunit of human 20S proteasome.

  International journal of molecular sciences 20110101

• Paliperidone-induced obsessive symptoms.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide.

  International journal of molecular sciences 20110101

• Mesomorphic properties of an homologous series of thioalkyl-terminated azomesogens.

  International journal of molecular sciences 20110101

• The small-molecule TNF-alpha modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo.

  Journal of experimental therapeutics & oncology 20110101

• Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.

  Respiratory research 20110101

• The quest for targeted delivery in colon cancer: mucoadhesive valdecoxib microspheres.

  International journal of nanomedicine 20110101

• Dose pattern and effectiveness of paliperidone extended-release tablets in patients with schizophrenia.

  Clinical neuropharmacology 20110101

• Zonisamide versus topiramate in migraine prophylaxis: a double-blind randomized clinical trial.

  Clinical neuropharmacology 20110101

• Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients.

  Arzneimittel-Forschung 20110101

• [How does one manage patients with rheumatoid arthritis and positive serology to hepatitis B, hepatitis C, human immunodeficiency virus?].

  Reumatologia clinica 20110101

• Novel benzimidazole derivatives as expected anticancer agents.

  Acta poloniae pharmaceutica 20110101

• Electron ionization and electrospray mass spectra of diaryl-substituted enaminoketones and their thio analogs.

  European journal of mass spectrometry (Chichester, England) 20110101

• [Novel iodocyclization method based on the controlling of oxidative aromatization].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101

• Neglected disease - african sleeping sickness: recent synthetic and modeling advances.

  Scientia pharmaceutica 20110101

• Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents.

  Scientia pharmaceutica 20110101

• Current and emerging treatments for uterine myoma - an update.

  International journal of women's health 20110101

• Improvement of oral dyskinesia after switching from aripiprazole to paliperidone: a case report.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Manic symptoms during a switch from risperidone to paliperidone: a case report.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Interstitial lung disease in rheumatoid arthritis: response to IL-6R blockade.

  Scandinavian journal of rheumatology 20110101

• Apparent acute idiosyncratic hepatic necrosis associated with zonisamide administration in a dog.

  Journal of veterinary internal medicine 20110101

• Impact of bile acids on the growth of human cholangiocarcinoma via FXR.

  Journal of hematology & oncology 20110101

• Efficacy of parecoxib, sumatriptan, and rizatriptan in the treatment of acute migraine attacks.

  Clinical neuropharmacology 20110101

• Novel treatment options of binge eating disorder.

  Current medicinal chemistry 20110101

• Renal tubular acidosis associated with zonisamide therapy in a dog.

  Journal of veterinary internal medicine 20110101

• Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats.

  PloS one 20110101

• [Peripheral neuropathy and leflunomide].

  Acta reumatologica portuguesa 20110101

• Brominated compounds from marine sponges of the genus Aplysina and a compilation of their 13C NMR spectral data.

  Marine drugs 20110101

• [Case of schizophrenia in which depressive and negative symptoms relapsed on switching from oral risperidone to risperidone long-acting injection].

  Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20110101

• Iloperidone: a clinical overview.

  The Journal of clinical psychiatry 20110101

• Irreversible inhibitors of tissue transglutaminase.

  Advances in enzymology and related areas of molecular biology 20110101

• Emergence of neuroleptic malignant syndrome while switching between risperidone and paliperidone.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Tardive Tourette-like syndrome in a patient treated with paliperidone.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• [Investigation vesicle cycle in nerve formations in somatic muscle of the earthworm Lumbricus terrestris].

  Tsitologiia 20110101

• Efficacy and safety of parecoxib in the treatment of acute renal colic: a randomized clinical trial.

  International braz j urol : official journal of the Brazilian Society of Urology 20110101

• Incidence and clinical implication of nosocomial infections associated with implantable biomaterials - catheters, ventilator-associated pneumonia, urinary tract infections.

  GMS Krankenhaushygiene interdisziplinar 20110101

• QSAR study and molecular design of open-chain enaminones as anticonvulsant agents.

  International journal of molecular sciences 20110101

• Disoxaril mutants of Coxsackievirus B1: phenotypic characteristics and analysis of the target VP1 gene.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101

• [Efficacy and tolerance of rezonizate in complex with fluoroquinolones or mycobutin on a model of experimental murine tuberculosis].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

• [New drugs in the treatment of adult patients with refractery epilepsy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• An unusual case of DRESS syndrome due to leflunomide.

  BMJ case reports 20110101

• Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection.

  Transplantation 20101227

• Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).

  Journal of medicinal chemistry 20101223

• Degradation of the herbicides clomazone, paraquat, and glyphosate by thermally activated peroxydisulfate.

  Journal of agricultural and food chemistry 20101222

• Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.

  Molecular pharmacology 20101201

• Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions.

  Psychopharmacology 20101201

• Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.

  European journal of medicinal chemistry 20101201

• A real-time screening assay for GIRK1/4 channel blockers.

  Journal of biomolecular screening 20101201

• Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats.

  Epilepsy research 20101201

• Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay.

  Thrombosis and haemostasis 20101201

• Iloperidone: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability, regulatory affairs, and an opinion.

  Expert opinion on drug metabolism & toxicology 20101201

• Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study.

  Therapeutic drug monitoring 20101201

• Association of 9-hydroxy risperidone concentrations with risk of switching or discontinuation in the clinical antipsychotic trial of intervention effectiveness-Alzheimer's disease trial.

  Journal of clinical psychopharmacology 20101201

• Comparison of the efficacy of parecoxib versus ketorolac combined with morphine on patient-controlled analgesia for post-cesarean delivery pain management.

  Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20101201

• The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds.

  Chemical communications (Cambridge, England) 20101128

• Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.

  Organic letters 20101119

• Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.

  Chemical research in toxicology 20101115

• Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies.

  The Journal of organic chemistry 20101105

• Synthesis of dihydrobenzisoxazoles by the [3 + 2] cycloaddition of arynes and oxaziridines.

  The Journal of organic chemistry 20101105

• Mechanism of K(v)2.1 channel inhibition by a selective COX-2 inhibitor SC-791-modification of gating.

  Brain research 20101104

• Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep.

  Journal of psychopharmacology (Oxford, England) 20101101

• The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA receptors.

  Journal of psychopharmacology (Oxford, England) 20101101

• Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice.

  Neurourology and urodynamics 20101101

• Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.

  Journal of bone and mineral metabolism 20101101

• Survivin is regulated by interleukin-4 in colon cancer stem cells.

  Journal of cellular physiology 20101101

• T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.

  Neuropharmacology 20101101

• The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode schizophrenia treated with risperidone.

  European journal of clinical pharmacology 20101101

• Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertension.

  Rheumatology (Oxford, England) 20101101

• Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice.

  Journal of lipid research 20101101

• Reduction of N-hydroxy-sulfonamides, including N-hydroxy-valdecoxib, by the molybdenum-containing enzyme mARC.

  Drug metabolism and disposition: the biological fate of chemicals 20101101

• Tolerability of paliperidone: a meta-analysis of randomized, controlled trials.

  International clinical psychopharmacology 20101101

• Endothelin-mediated gut microcirculatory dysfunction during porcine endotoxaemia.

  British journal of anaesthesia 20101101

• Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor.

  European journal of medicinal chemistry 20101101

• Synthesis and molluscicidal evaluation of some new pyrazole, isoxazole, pyridine, pyrimidine, 1,4-thiazine and 1,3,4-thiadiazine derivatives incorporating benzofuran moiety.

  European journal of medicinal chemistry 20101101

• Enthalpy relaxation studies of two structurally related amorphous drugs and their binary dispersions.

  Drug development and industrial pharmacy 20101101

• Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study.

  The Journal of clinical psychiatry 20101101

• Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.

  Pharmacopsychiatry 20101101

• [Causes of selectivity, activation and inhibition. Molecular mechanisms of endothelin-receptor recognition].

  Pharmazie in unserer Zeit 20101101

• [Rituximab in the treatment of acquired haemophilia A in a patient with polymyalgia rheumatica].

  Hamostaseologie 20101101

• Development of an image-based system for measurement of membrane potential, intracellular Ca(2+) and contraction in arteriolar smooth muscle cells.

  Microcirculation (New York, N.Y. : 1994) 20101101

• [Preemptive analgesic effect of parecoxib sodium in patients undergoing laparoscopic colorectal surgery].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101101

• Alterations in cyclic alternating pattern associated with phase advanced sleep are differentially modulated by gaboxadol and zolpidem.

  Sleep 20101101

• Relative bioavailability of two oral formulations of risperidone 2 mg: A single-dose, randomized-sequence, open-label, two-period crossover comparison in healthy Brazilian volunteers.

  Clinical therapeutics 20101101

• 1,5-Dimethyl-3-[(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)meth-yl]-1H-1,5-benzodiazepine-2,4(3H,5H)-dione.

  Acta crystallographica. Section E, Structure reports online 20101101

• 4-tert-Butyl-4'-(4-meth-oxy-phen-yl)-3'-(4-methyl-phen-yl)-1,2,3,4-tetra-hydro-spiro-[naphthalene-2,5'(4'H)-1,2-oxazol]-1-one.

  Acta crystallographica. Section E, Structure reports online 20101101

• [Discovery of an antiparkinsonian drug: zonisamide].

  Rinsho shinkeigaku = Clinical neurology 20101101

• Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan.

  International journal of cardiology 20101029

• Novel agonists and antagonists for human protease activated receptor 2.

  Journal of medicinal chemistry 20101028

• Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy.

  Transplantation 20101027

• Synthesis, antimicrobial, and mosquito larvicidal activity of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones.

  Bioorganic & medicinal chemistry letters 20101015

• A gram-scale batch and flow total synthesis of perhydrohistrionicotoxin.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20101004

• Zonisamide in managing impulse control disorders in Parkinson's disease.

  Journal of neurology 20101001

• Preincisional versus postincisional administration of parecoxib in colorectal surgery: effect on postoperative pain control and cytokine response. A randomized clinical trial.

  World journal of surgery 20101001

• Paliperidone-induced mania-like symptoms: a case report.

  Progress in neuro-psychopharmacology & biological psychiatry 20101001

• Macrophage activation syndrome after leflunomide treatment in an adult rheumatoid arthritis patient.

  Rheumatology (Oxford, England) 20101001

• Gender differences in the relationship between the risperidone metabolism and the plasma prolactin levels in psychiatric patients.

  Progress in neuro-psychopharmacology & biological psychiatry 20101001

• Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats.

  Brain research 20101001

• Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.

  European journal of medicinal chemistry 20101001

• Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.

  American journal of physiology. Heart and circulatory physiology 20101001

• The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae.

  The Journal of antibiotics 20101001

• Paliperidone extended-release in schizoaffective disorder: a randomized, controlled study comparing a flexible dose with placebo in patients treated with and without antidepressants and/or mood stabilizers.

  Journal of clinical psychopharmacology 20101001

• Base-catalyzed isomerization of 2-isoxazolines enables a two-step enantioselective synthesis of β-hydroxynitriles from enals.

  The Journal of organic chemistry 20101001

• Renal failure five years after lung transplantation due to polyomavirus BK-associated nephropathy.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20101001

• Paliperidone extended-release: a review of efficacy and tolerability in schizophrenia, schizoaffective disorder and bipolar mania.

  Expert opinion on pharmacotherapy 20101001

• Short-term treatment with COX-2 inhibitors does not impair fracture healing.

  Journal of investigative surgery : the official journal of the Academy of Surgical Research 20101001

• Parecoxib and fatal skin reactions: when will this drug be withdrawn from the European Union market?

  Prescrire international 20101001

• 5-(4-Chloro-phen-yl)-6-isopropyl-5,6-dihydro-4H-pyrrolo-[3,4-c]isoxazole.

  Acta crystallographica. Section E, Structure reports online 20101001

• 4-[(2-Hy-droxy-benzyl-idene)amino]-N-(5-methyl-isoxazol-3-yl)benzene-sulfonamide: a monoclinic polymorph.

  Acta crystallographica. Section E, Structure reports online 20101001

• Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.

  Organic & biomolecular chemistry 20100921

• Bitter pills for drug companies.

  BMJ (Clinical research ed.) 20100917

• [Psychosis due to zonisamide: an infrequent case].

  Revista de neurologia 20100916

• Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.

  Neuroscience letters 20100906

• Efficacy and safety of paliperidone palmitate in adult patients with acutely symptomatic schizophrenia: a randomized, double-blind, placebo-controlled, dose-response study.

  International clinical psychopharmacology 20100901

• Maternal exposure to leflunomide and methotrexate in a patient with adult-onset Still's disease.

  Rheumatology (Oxford, England) 20100901

• In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.

  The Journal of pharmacology and experimental therapeutics 20100901

• Eudragit S-100 entrapped chitosan microspheres of valdecoxib for colon cancer.

  Journal of materials science. Materials in medicine 20100901

• A controlled, evidence-based trial of paliperidone palmitate, a long-acting injectable antipsychotic, in schizophrenia.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100901

• Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents.

  European journal of medicinal chemistry 20100901

• Design and synthesis of novel isoxazole-based HDAC inhibitors.

  European journal of medicinal chemistry 20100901

• Zonisamide ameliorates symptoms of secondary paroxysmal dystonia.

  Pediatric neurology 20100901

• High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo.

  Arteriosclerosis, thrombosis, and vascular biology 20100901

• Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets.

  The Journal of thoracic and cardiovascular surgery 20100901

• Leflunomide: a drug with a potential beyond rheumatology.

  Immunotherapy 20100901

• New antipsychotic drugs: how do their receptor-binding profiles compare?

  The Journal of clinical psychiatry 20100901

• Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice.

  Metabolic brain disease 20100901

• [9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus].

  Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20100901

• Relative bioavailability and pharmacokinetic comparison of two 2-mg risperidone tablet formulations: A single dose, randomized-sequence, double-blind, 2-way crossover study in healthy male volunteers in Thailand.

  Clinical therapeutics 20100901

• Leflunomide: a small step forward in meeting the urgent need for treatment of drug-resistant cytomegalovirus infection.

  Transplantation 20100827

• Utility of leflunomide in the treatment of complex cytomegalovirus syndromes.

  Transplantation 20100827

• Successful treatment of extrapyramidal and psychotic symptoms with zonisamide in a patient with dementia with Lewy bodies.

  Progress in neuro-psychopharmacology & biological psychiatry 20100816

• Using aripiprazole to attenuate paliperidone-induced hyperprolactinemia.

  Progress in neuro-psychopharmacology & biological psychiatry 20100816

• Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs).

  Archives of biochemistry and biophysics 20100815

• Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.

  Bioorganic & medicinal chemistry letters 20100815

• Chromatographic separation and sensitive determination of teriflunomide, an active metabolite of leflunomide in human plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100815

• Zonisamide discontinuation due to psychiatric and cognitive adverse events: a case-control study.

  Neurology 20100810

• Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100809

• [Efficacy of paliperidone extended-release tablets in the improvement of social functions in schizophrenics: a randomized and controlled study].

  Zhonghua yi xue za zhi 20100803

• A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.

  Journal of lipid research 20100801

• Serum concentrations of paliperidone versus risperidone and clinical effects.

  European journal of clinical pharmacology 20100801

• Comment on: Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis.

  Rheumatology (Oxford, England) 20100801

• Zonisamide: aspects in neuroprotection.

  Experimental neurology 20100801

• Effectiveness of leflunomide in patients with juvenile idiopathic arthritis in clinical practice.

  The Journal of rheumatology 20100801

• Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study.

  Clinical rheumatology 20100801

• Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?

  Current hypertension reports 20100801

• Iloperidone for schizophrenia.

  Expert opinion on pharmacotherapy 20100801

• Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.

  Bioorganic & medicinal chemistry letters 20100801

• Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome.

  International journal of clinical pharmacology and therapeutics 20100801

• Neuroleptic malignant syndrome secondary to aripiprazole initiation in a clozapine-intolerant patient.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100801

• Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats.

  Basic & clinical pharmacology & toxicology 20100801

• One-year open-label safety and efficacy study of paliperidone extended-release tablets in patients with schizophrenia.

  CNS spectrums 20100801

• The post-operative analgesic efficacy of celecoxib compared with placebo and parecoxib after total hip or knee arthroplasty.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100801

• Iloperidone for the treatment of schizophrenia.

  Drugs of today (Barcelona, Spain : 1998) 20100801

• tert-Butyl 3-(8-bromo-4H,10H-1,2-oxazolo[4,3-c][1]benzoxepin-10-yl)-2-methyl-1H-indole-1-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20100801

• 2,10-Bis(3-bromo-phen-yl)-3,7,11,15-tetra-oxa-8,16-diaza-tricyclo-[12.2.1.1]octa-deca-1(16),6(18),8,14(17)-tetra-ene.

  Acta crystallographica. Section E, Structure reports online 20100801

• N-(4-Chloro-benzyl-idene)-3,4-dimethyl-isoxazol-5-amine.

  Acta crystallographica. Section E, Structure reports online 20100801

• Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100721

• [Effects of parecoxib sodium preemptive analgesia on perioperative cytokine responses and stress responses in patients undergoing ophthalmology surgery].

  Zhonghua yi xue za zhi 20100720

• Paliperidone extended release: a review of its use in the management of schizophrenia.

  Drugs 20100709

• The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.

  FEBS letters 20100702

• Relationship between response to risperidone, plasma concentrations of risperidone and CYP3A4 polymorphisms in schizophrenia patients.

  Journal of psychopharmacology (Oxford, England) 20100701

• Clinical response to risperidone in relation to plasma drug concentrations in acutely exacerbated schizophrenic patients.

  Journal of psychopharmacology (Oxford, England) 20100701

• Preemptive analgesia reduces pain after radical axillary lymph node dissection.

  The Journal of surgical research 20100701

• A comparison of serum prolactin concentrations after administration of paliperidone extended-release and risperidone tablets in patients with schizophrenia.

  Journal of psychopharmacology (Oxford, England) 20100701

• Dual fluorochrome flow cytometric assessment of yeast viability.

  Current microbiology 20100701

• The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy.

  Experimental neurology 20100701

• Long-acting injectable risperidone and metabolic ratio: a possible index of clinical outcome in treatment-resistant schizophrenic patients.

  Psychopharmacology 20100701

• Single-dose pharmacokinetics of paliperidone extended-release tablets in healthy Chinese subjects.

  Human psychopharmacology 20100701

• Pharmacotherapy: Is there a place for leflunomide in the treatment of RA?

  Nature reviews. Rheumatology 20100701

• Paliperidone palmitate injection: Its efficacy, safety and tolerability in schizophrenia.

  Drugs of today (Barcelona, Spain : 1998) 20100701

• [Different expression of GluR5 and GluR6 in rat astrocyte induced with coriaria lactone and ATPA].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100701

• Ligand-exchange processes on solvated zinc cations: water exchange on [Zn(H2O)4(L)]2+.2H2O (L=heterocyclic ligand).

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100625

• Pulvinar inactivation disrupts selection of movement plans.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100623

• The synthesis of glycyrrhetinic acid derivatives containing a nitrogen heterocycle and their antiproliferative effects in human leukemia cells.

  Molecules (Basel, Switzerland) 20100621

• Intramolecular Fe(II)-catalyzed N-O or N-N bond formation from aryl azides.

  Organic letters 20100618

• Preparation and evaluation of biodegradable microspheres containing a new potent osteogenic compound and new synthetic polymers for sustained release.

  International journal of pharmaceutics 20100615

• Synthesis and antitumor activity of 2,5-bis(3'-indolyl)-furans and 3,5-bis(3'-indolyl)-isoxazoles, nortopsentin analogues.

  Bioorganic & medicinal chemistry 20100615

• Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes.

  Bioorganic & medicinal chemistry 20100615

• Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens.

  Bioorganic & medicinal chemistry letters 20100615

• Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors.

  Bioorganic & medicinal chemistry letters 20100615

• Expanding the family of mesoionic complexes: donor properties and catalytic impact of palladated isoxazolylidenes.

  Dalton transactions (Cambridge, England : 2003) 20100614

• Chemical synthesis of heterocyclic-sugar nucleoside analogues.

  Chemical reviews 20100609

• An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne.

  Organic & biomolecular chemistry 20100607

• An expeditious synthesis of [1,2]isoxazolidin-5-ones and [1,2]oxazin-6-ones from functional allyl bromide derivatives.

  Molecules (Basel, Switzerland) 20100607

• Paliperidone palmitate, a potential long-acting treatment for patients with schizophrenia. Results of a randomized, double-blind, placebo-controlled efficacy and safety study.

  The international journal of neuropsychopharmacology 20100601

• Inconsistency in risperidone long-acting injection steady-state plasma levels when switching from deltoid to gluteal administration.

  Journal of clinical pharmacology 20100601

• HRCT-proven leflunomide pneumonitis in a patient with psoriatic arthritis and normal lung function tests and chest radiography.

  Rheumatology (Oxford, England) 20100601

• Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors.

  European journal of medicinal chemistry 20100601

• Synthesis and in vitro study of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles as potential nematicidal agents.

  European journal of medicinal chemistry 20100601

• Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.

  Neuropharmacology 20100601

• Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.

  Neurobiology of disease 20100601

• Effect of CYP2D6, CYP3A5, and MDR1 genetic polymorphisms on the pharmacokinetics of risperidone and its active moiety.

  Journal of clinical pharmacology 20100601

• Greater functional ETB receptor antagonism with bosentan than sitaxsentan in healthy men.

  Hypertension (Dallas, Tex. : 1979) 20100601

• Administration of zonisamide in three cases of dementia with Lewy bodies.

  Psychiatry and clinical neurosciences 20100601

• Nuclear hormone receptors in diabetic nephropathy.

  Nature reviews. Nephrology 20100601

• Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice.

  Metabolic brain disease 20100601

• Postoperative analgesia with parecoxib, acetaminophen, and the combination of both: a randomized, double-blind, placebo-controlled trial in patients undergoing thyroid surgery.

  British journal of anaesthesia 20100601

• Hyperprolactinaemia during treatment with paliperidone.

  Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists 20100601

• Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy.

  Epilepsy research 20100601

• Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death.

  Bioorganic & medicinal chemistry 20100601

• A randomized, placebo-controlled study to assess the efficacy and safety of 3 doses of paliperidone palmitate in adults with acutely exacerbated schizophrenia.

  Journal of clinical psychopharmacology 20100601

• Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.

  Journal of clinical psychopharmacology 20100601

• Leflunomide in combination therapy for rheumatoid arthritis.

  Drug safety 20100601

• Efficacy and tolerability of paliperidone ER and other oral atypical antipsychotics in schizophrenia.

  International journal of clinical pharmacology and therapeutics 20100601

• Healing of erosive disease in multicentric reticulohistiocytosis.

  The Journal of rheumatology 20100601

• Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention.

  Neoplasia (New York, N.Y.) 20100601

• [Postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100601

• Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings.

  Archives of pharmacal research 20100601

• Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.

  Canadian journal of physiology and pharmacology 20100601

• Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation.

  Chinese medical journal 20100601

• X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.

  Journal of molecular biology 20100528

• Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526

• Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.

  British journal of cancer 20100525

• A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model.

  Fertility and sterility 20100515

• Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists.

  Bioorganic & medicinal chemistry 20100515

• Unexpected heterocyclization of electrophilic alkenes by tetranitromethane in the presence of triethylamine. Synthesis of 3-nitroisoxazoles.

  The Journal of organic chemistry 20100507

• An unnatural amino acid that mimics phosphotyrosine.

  Chemical communications (Cambridge, England) 20100507

• Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

  Lung cancer (Amsterdam, Netherlands) 20100501

• Severe aplastic anaemia following leflunomide therapy.

  Rheumatology (Oxford, England) 20100501

• Comparison of combination therapies in the treatment of rheumatoid arthritis: leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha.

  Clinical rheumatology 20100501

• Birth outcomes in women who have taken leflunomide during pregnancy.

  Arthritis and rheumatism 20100501

• Assessing the chemical diversity of an hsp90 database.

  European journal of medicinal chemistry 20100501

• Adherence to disease-modifying antirheumatic drugs and the effects of exposure misclassification on the risk of hospital admission.

  Arthritis care & research 20100501

• Iloperidone redux: a dissection of the Drug Approval Package for this newly commercialised second-generation antipsychotic.

  International journal of clinical practice 20100501

• Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone.

  Plant physiology 20100501

• Medication satisfaction in schizophrenia: a blinded-initiation study of paliperidone extended release in patients suboptimally responsive to risperidone.

  International clinical psychopharmacology 20100501

• Efficacy and safety of combining intra-articular methylprednisolone and anti-TNF agent to achieve prolonged remission in patients with recurrent inflammatory monoarthritis.

  Joint, bone, spine : revue du rhumatisme 20100501

• Iloperidone for the treatment of schizophrenia.

  The Annals of pharmacotherapy 20100501

• 89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100501

• The enhancement of contextual fear conditioning by ABT-418.

  Behavioural pharmacology 20100501

• Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.

  Molecular cancer therapeutics 20100501

• Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.

  Chemical biology & drug design 20100501

• A randomized, double-blind, placebo-controlled study of 2 dose ranges of paliperidone extended-release in the treatment of subjects with schizoaffective disorder.

  The Journal of clinical psychiatry 20100501

• A randomized, placebo- and active-controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder.

  Bipolar disorders 20100501

• Efficacy and safety of atypical antipsychotic drugs (quetiapine, risperidone, aripiprazole and paliperidone) compared with placebo or typical antipsychotic drugs for treating refractory schizophrenia: overview of systematic reviews.

  Sao Paulo medical journal = Revista paulista de medicina 20100501

• 1-[(E)-(3,4-Dimethyl-isoxazol-5-yl)imino-meth-yl]-2-naphthol.

  Acta crystallographica. Section E, Structure reports online 20100501

• Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors.

  The Journal of physiology 20100415

• A clomazone immunoassay to study the environmental fate of the herbicide in rice (Oryza sativa) agriculture.

  Journal of agricultural and food chemistry 20100414

• Validation of method for determination of different classes of pesticides in aqueous samples by dispersive liquid-liquid microextraction with liquid chromatography-tandem mass spectrometric detection.

  Analytica chimica acta 20100414

• Molecular characterization of agonists that bind to an insect GABA receptor.

  Biochemistry 20100406

• Abatacept as an option therapy in difficult to treat psoriatic arthritis.

  Rheumatology international 20100401

• Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.

  European journal of haematology 20100401

• Cyclooxygenase 2 inhibition exacerbates AQP2 and pAQP2 downregulation independently of V2 receptor abundance in the postobstructed kidney.

  American journal of physiology. Renal physiology 20100401

• Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells.

  Critical care medicine 20100401

• A prospective audit of adjunctive zonisamide in an everyday clinical setting.

  Epilepsy & behavior : E&B 20100401

• Pharmacokinetic comparison and bioequivalence of two leflunomide formulations in humans: a single dose, randomized, open-label, two-way crossover study.

  International journal of clinical pharmacology and therapeutics 20100401

• Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.

  Molecular cancer therapeutics 20100401

• Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment.

  Annals of the New York Academy of Sciences 20100401

• Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes.

  Annals of the New York Academy of Sciences 20100401

• Paliperidone use in the elderly.

  Current drug safety 20100401

• Biotransformation of valdecoxib by microbial cultures.

  Journal of microbiology and biotechnology 20100401

• Zonisamide: a new drug for Parkinson's disease.

  Drugs of today (Barcelona, Spain : 1998) 20100401

• New-onset psoriasis associated with etanercept therapy.

  The Journal of dermatology 20100401

• Manic symptoms induced by paliperidone.

  Journal of clinical psychopharmacology 20100401

• Terizidone.

  The Journal of the Association of Physicians of India 20100401

• Ethyl 3-{5-[(diethyl-amino)meth-yl]isoxazol-3-yl}-2-phenyl-pyrazolo[1,5-a]pyridine-5-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20100401

• 2-[(E)-(3,4-Dimethyl-isoxazol-5-yl)imino-meth-yl]phenol.

  Acta crystallographica. Section E, Structure reports online 20100401

• 5-(4-Fluoro-phen-yl)-4-(4-pyrid-yl)-1,3-oxazol-2-amine.

  Acta crystallographica. Section E, Structure reports online 20100401

• Microbial degradation of clomazone under simulated California rice field conditions.

  Journal of agricultural and food chemistry 20100324

• Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols.

  The Journal of organic chemistry 20100319

• Paliperidone overdose in a patient with schizophrenia.

  Progress in neuro-psychopharmacology & biological psychiatry 20100317

• Design, synthesis, and herbicidal activities of novel 2-cyanoacrylates containing isoxazole moieties.

  Journal of agricultural and food chemistry 20100310

• Effects of quetiapine, risperidone, 9-hydroxyrisperidone and ziprasidone on the survival of human neuronal and immune cells in vitro.

  Journal of psychopharmacology (Oxford, England) 20100301

• Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy.

  Brain & development 20100301

• Pharmacophore mapping and electronic feature analysis for a series of nitroaromatic compounds with antitubercular activity.

  Journal of computational chemistry 20100301

• Prevalence of positive ppd in a cohort of rheumatoid arthritis patients.

  Rheumatology international 20100301

• A comparison of continuous subcutaneous paliperidone infusion and repeated subcutaneous injection of risperidone free-base in rats.

  European psychiatry : the journal of the Association of European Psychiatrists 20100301

• Leflunomide: is a new oral agent in treatment of acute pancreatitis?

  Pancreas 20100301

• The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.

  Epilepsia 20100301

• High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells.

  Journal of cellular physiology 20100301

• Rituximab and concomitant leflunomide for the treatment of rheumatoid arthritis.

  Rheumatology international 20100301

• Flexible dosing of adjunctive zonisamide in the treatment of adult partial-onset seizures: a non-comparative, open-label study (ZEUS).

  Acta neurologica Scandinavica 20100301

• Modeling the effectiveness of paliperidone ER and olanzapine in schizophrenia: meta-analysis of 3 randomized, controlled clinical trials.

  Journal of clinical pharmacology 20100301

• A rapid and simple high-performance liquid chromatography assay for the leflunomide metabolite, teriflunomide (A77 1726), in renal transplant recipients.

  American journal of clinical pathology 20100301

• Intramuscular paliperidone palmitate.

  CNS drugs 20100301

• Remission of drug-induced hepatitis after switching from risperidone to paliperidone.

  The American journal of psychiatry 20100301

• Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study.

  Journal of clinical anesthesia 20100301

• Serum concentrations, therapeutic response and side effects in children and adolescents with impulsive-aggressive symptoms during risperidone therapy.

  Pharmacopsychiatry 20100301

• Open label trial of the tolerability and efficacy of zonisamide in the treatment of alcohol dependence.

  The American journal of drug and alcohol abuse 20100301

• Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.

  The European journal of neuroscience 20100301

• (3-Phenyl-isoxazol-5-yl)methanol.

  Acta crystallographica. Section E, Structure reports online 20100301

• Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone.

  Psychiatry research 20100227

• An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne.

  Chemical communications (Cambridge, England) 20100227

• Iloperidone (Fanapt)--another second-generation antipsychotic.

  The Medical letter on drugs and therapeutics 20100222

• Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

  The Journal of biological chemistry 20100219

• Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes).

  Toxicology and applied pharmacology 20100215

• Phenyltriazolinones as potent factor Xa inhibitors.

  Bioorganic & medicinal chemistry letters 20100215

• Effect of gaboxadol on patient-reported measures of sleep and waking function in patients with Primary Insomnia: results from two randomized, controlled, 3-month studies.

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20100215

• Combination regimen of leflunomide plus methylprednisolone in a female patient with reactive arthritis and concomitant IgA nephropathy.

  Chinese medical journal 20100205

• Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion.

  Digestive diseases and sciences 20100201

• Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients.

  Pediatric transplantation 20100201

• Electroencephalographic responses of tramadol, parecoxib and morphine to acute noxious electrical stimulation in anaesthetised dogs.

  Research in veterinary science 20100201

• Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia.

  Clinical pharmacology and therapeutics 20100201

• The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats.

  Toxicology and applied pharmacology 20100201

• Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].

  The Journal of pharmacology and experimental therapeutics 20100201

• The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance.

  Experimental neurology 20100201

• Paliperidone palmitate maintenance treatment in delaying the time-to-relapse in patients with schizophrenia: a randomized, double-blind, placebo-controlled study.

  Schizophrenia research 20100201

• Practical guidance for dosing and switching paliperidone palmitate treatment in patients with schizophrenia.

  Current medical research and opinion 20100201

• Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats.

  Pain 20100201

• Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

• Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs.

  Bioorganic & medicinal chemistry letters 20100201

• (89)Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft.

  European journal of cancer (Oxford, England : 1990) 20100201

• Possible neuroleptic malignant syndrome during paliperidone administration: a case report.

  Journal of clinical psychopharmacology 20100201

• Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.

  Neuroscience bulletin 20100201

• Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth.

  Molecular cancer therapeutics 20100201

• Efficacy of leflunomide for treatment of immune-mediated polyarthritis in dogs: 14 cases (2006-2008).

  Journal of the American Veterinary Medical Association 20100201

• The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension.

  The European respiratory journal 20100201

• Effect of leflunomide on liver regeneration after partial hepatectomy in rats.

  Pediatric surgery international 20100201

• [Zonisamide in the preventive treatment of refractory migraine].

  Revista de neurologia 20100201

• Paliperidone for irritability in autistic disorder.

  Journal of child and adolescent psychopharmacology 20100201

• Endometriosis: in search of optimal treatment.

  Minerva ginecologica 20100201

• [The discovery of an antiparkinsonian drug, zonisamide].

  Rinsho shinkeigaku = Clinical neurology 20100201

• Paliperidone extended-release tablets in patients with recently diagnosed schizophrenia.

  Early intervention in psychiatry 20100201

• [Endothelin receptor antagonists in the new European guidelines on pulmonary hypertension].

  Revue des maladies respiratoires 20100201

• Measuring social functioning with the personal and social performance scale in patients with acute symptoms of schizophrenia: interpretation of results of a pooled analysis of three Phase III trials of paliperidone extended-release tablets.

  Clinical therapeutics 20100201

• [Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review].

  Drugs of today (Barcelona, Spain : 1998) 20100201

• Neuroprotective effects of zonisamide target astrocyte.

  Annals of neurology 20100201

• Infantile spasms: who are the ideal surgical candidates?

  Epilepsia 20100201

• Steady-state pharmacokinetics of zonisamide in plasma, whole blood, and erythrocytes in dogs.

  Journal of veterinary pharmacology and therapeutics 20100201

• Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles.

  Future medicinal chemistry 20100201

• 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100131

• Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development.

  Journal of medicinal chemistry 20100128

• Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition.

  Organic & biomolecular chemistry 20100121

• Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection.

  World journal of gastroenterology 20100114

• Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide.

  Annals of the rheumatic diseases 20100101

• Measure of function in rheumatoid arthritis: individualised or classical scales?

  Annals of the rheumatic diseases 20100101

• Efficacy and safety of paliperidone extended-release in schizophrenia patients with prominent affective symptoms.

  Journal of affective disorders 20100101

• Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596.

  Journal of molecular neuroscience : MN 20100101

• Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency.

  Biotechnology letters 20100101

• Microarray analysis of Leflunomide-induced limb malformations in CD-1 mice.

  Reproductive toxicology (Elmsford, N.Y.) 20100101

• Paliperidone palmitate - review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication.

  International journal of clinical practice 20100101

• [Hepatotoxicity induced by new immunosuppressants].

  Gastroenterologia y hepatologia 20100101

• Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction.

  Experimental neurology 20100101

• Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.

  Bioorganic & medicinal chemistry letters 20100101

• Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model.

  Bioorganic & medicinal chemistry 20100101

• Zonisamide-induced weight loss in schizophrenia: case series.

  Clinical neuropharmacology 20100101

• Effectiveness and tolerability of zonisamide in children with epilepsy: a retrospective review.

  Seizure 20100101

• Water mediated construction of trisubstituted pyrazoles/isoxazoles library using ketene dithioacetals.

  Journal of combinatorial chemistry 20100101

• Zonisamide in the treatment of epilepsy.

  Expert opinion on pharmacotherapy 20100101

• Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.

  Addiction biology 20100101

• Zonisamide in Parkinson's disease: profile report.

  Drugs & aging 20100101

• Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101

• The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects.

  British journal of clinical pharmacology 20100101

• Effects of Parecoxib and Fentanyl on nociception-induced cortical activity.

  Molecular pain 20100101

• New drugs: asenapine, iloperidone, and bepotastine besilate.

  Journal of the American Pharmacists Association : JAPhA 20100101

• The pharmacokinetics of paliperidone versus risperidone.

  Psychosomatics 20100101

• Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4+CD25+ regulatory T cells.

  Canadian journal of physiology and pharmacology 20100101

• Regulation of cerebromicrovascular permeability by lysophosphatidic acid.

  Microcirculation (New York, N.Y. : 1994) 20100101

• Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy?

  BMC cardiovascular disorders 20100101

• Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.

  Internal medicine (Tokyo, Japan) 20100101

• A randomised comparison of parecoxib versus placebo for pain management following minor day stay gynaecological surgery.

  Anaesthesia and intensive care 20100101

• The role of macrophage migration inhibitory factor in Alzheimer's disease.

  Molecular medicine (Cambridge, Mass.) 20100101

• [Therapeutic drug monitoring of zonisamide].

  Therapie 20100101

• Oral Therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis.

  Applied health economics and health policy 20100101

• Leg ulceration in rheumatoid arthritis--an underreported multicausal complication with considerable morbidity: analysis of thirty-six patients and review of the literature.

  Dermatology (Basel, Switzerland) 20100101

• New atypical antipsychotics for schizophrenia: iloperidone.

  Drug design, development and therapy 20100101

• Methotrexate plus leflunomide for the treatment of relapsingWegener's granulomatosis. A retrospective uncontrolled study.

  Clinical and experimental rheumatology 20100101

• ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma.

  Molecular medicine (Cambridge, Mass.) 20100101

• Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.

  Folia biologica 20100101

• In vitro and in vivo comparison of the anti-staphylococcal efficacy of generic products and the innovator of oxacillin.

  BMC infectious diseases 20100101

• [Diagnosis and management of small vessel vasculitides].

  Duodecim; laaketieteellinen aikakauskirja 20100101

• Eco-contribution for the production of N-arylnitrones: solvent-free and assisted by microwaves.

  International journal of molecular sciences 20100101

• The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants.

  PloS one 20100101

• Effects of zonisamide in the treatment of alcohol dependence.

  Clinical neuropharmacology 20100101

• Selective COX-1 inhibition: A therapeutic target to be reconsidered.

  Current medicinal chemistry 20100101

• Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3.

  Drug metabolism and pharmacokinetics 20100101

• Exploratory analysis of psychiatric-related utilization and costs associated with paliperidone ER compared with other oral atypical antipsychotics using pharmacy claims from an administrative database.

  Journal of medical economics 20100101

• Influence of long-term leflunomide treatment on serum amyloid concentration in rheumatoid arthritis patients.

  Pharmacological reports : PR 20100101

• Macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa B activation during Vibrio vulnificus infection.

  BMC immunology 20100101

• Zonisamide attenuates MPTP neurotoxicity in marmosets.

  Journal of pharmacological sciences 20100101

• The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor.

  PloS one 20100101

• Paliperidone-induced dystonic Dysphagia.

  The Journal of neuropsychiatry and clinical neurosciences 20100101

• Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand.

  PloS one 20100101

• Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596.

  PloS one 20100101

• Does the anti-herpesviral effect of leflunomide play a role in the treatment of rheumatoid arthritis?

  Clinical and experimental rheumatology 20100101

• [Non-fatal paliperidone overdose: a case report].

  Turk psikiyatri dergisi = Turkish journal of psychiatry 20100101

• Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.

  The open medicinal chemistry journal 20100101

• [Peripheral neuropathy caused by leflunomide. A case reported with a brief review].

  Revista medica del Instituto Mexicano del Seguro Social 20100101

• The pharmacotherapy of alcohol dependence: a state of the art review.

  Mens sana monographs 20100101

• [Active psoriatic arthritis during pregnancy: challenges and limitations of pharmacotherapy].

  Annales Academiae Medicae Stetinensis 20100101

• (E)-N'-Benzyl-idene-5-methyl-isoxazole-4-carbohydrazide.

  Acta crystallographica. Section E, Structure reports online 20100101

• 5-Methyl-N'-(3-nitrobenzylidene)isoxazole-4-carbohydrazide.

  Acta crystallographica. Section E, Structure reports online 20100101

• QSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B.

  Journal of pharmacy & bioallied sciences 20100101

• [Treatment of rheumatoid and psoriatic arthritis--review of leflunomide].

  Reumatizam 20100101

• Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.

  Journal of medicinal chemistry 20091224

• Efficient chemoenzymatic dynamic kinetic resolution of 1-heteroaryl ethanols.

  The Journal of organic chemistry 20091218

• Enantioselective intramolecular oxidative aminocarbonylation of alkenylureas catalyzed by palladium-spiro bis(isoxazoline) complexes.

  The Journal of organic chemistry 20091218

• 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.

  Journal of medicinal chemistry 20091210

• Simultaneous determination of risperidone and 9-hydroxyrisperidone enantiomers in human blood plasma by liquid chromatography with electrochemical detection.

  Journal of pharmaceutical and biomedical analysis 20091205

• Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: a structure-activity relationship study.

  Investigational new drugs 20091201

• Comparative effectiveness of tumour necrosis factor alpha inhibitors in combination with either methotrexate or leflunomide.

  Annals of the rheumatic diseases 20091201

• Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem.

  Journal of sleep research 20091201

• Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges.

  Biochemical pharmacology 20091201

• Analgesic, anticonvulsant and anti-inflammatory activities of some synthesized benzodiazipine, triazolopyrimidine and bis-imide derivatives.

  European journal of medicinal chemistry 20091201

• Enaminonitrile in heterocyclic synthesis: synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety.

  European journal of medicinal chemistry 20091201

• Leflunomide for the successful management of juvenile Cogan's syndrome.

  Clinical rheumatology 20091201

• Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity.

  Journal of neurochemistry 20091201

• Impact of CYP2D6 genotype on steady-state serum concentrations of risperidone and 9-hydroxyrisperidone in patients using long-acting injectable risperidone.

  Journal of clinical psychopharmacology 20091201

• Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus.

  The European journal of neuroscience 20091201

• Iloperidone: a new option for the treatment of schizophrenia.

  Expert review of neurotherapeutics 20091201

• Successful treatment of leflunomide-induced acute pneumonitis with cholestyramine wash-out therapy.

  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20091201

• Zonisamide in West syndrome: an open label study.

  Epileptic disorders : international epilepsy journal with videotape 20091201

• Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.

  British journal of pharmacology 20091201

• Multimodal pain management following minimally invasive total knee arthroplasty: an experience in 3-dose parecoxib.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20091201

• [Successful quetiapine therapy in psychotic patients with mood elevation].

  Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20091201

• Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction.

  Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20091201

• 1-(3-p-Tolyl-isoxazol-5-yl)cyclo-hexa-nol.

  Acta crystallographica. Section E, Structure reports online 20091201

• 4-(2-Hydroxy-benzyl-idene)-3-methyl-isoxazol-5(4H)-one.

  Acta crystallographica. Section E, Structure reports online 20091201

• (Z)-4-[4-(Dimethyl-amino)benzyl-idene]-3-methyl-isoxazol-5(4H)-one.

  Acta crystallographica. Section E, Structure reports online 20091201

• N'-[(E)-2-Hydroxy-benzyl-idene]-5-methyl-isoxazole-4-carbohydrazide monohydrate.

  Acta crystallographica. Section E, Structure reports online 20091201

• 5-Methyl-isoxazole-4-carboxylic acid.

  Acta crystallographica. Section E, Structure reports online 20091201

• (20S,2''S)-20-[4'-(3''-Hydroxy-2''-methyl-prop-yl)-3'-methylisoxazol-5-yl]-5β-preg-nan-3β,16β-diol.

  Acta crystallographica. Section E, Structure reports online 20091201

• [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases].

  Ideggyogyaszati szemle 20091130

• Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs.

  Transplantation 20091127

• From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.

  Journal of medicinal chemistry 20091126

• Role of water in the multifaceted catalytic antibody 4B2 for allylic isomerization and Kemp elimination reactions.

  The journal of physical chemistry. B 20091119

• Simple, rapid, and highly sensitive detection of diphosgene and triphosgene by spectrophotometric methods.

  Talanta 20091115

• Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series.

  Bioorganic & medicinal chemistry letters 20091115

• Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy.

  Bioorganic & medicinal chemistry letters 20091115

• Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.

  Journal of medicinal chemistry 20091112

• [Referring to an unusual case: pulmonary affection and rheumatoid arthritis].

  Revue medicale suisse 20091111

• 3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: synthesis of sulfonates and sulfonamides.

  Organic & biomolecular chemistry 20091107

• In brief: Injectable paliperidone palmitate for schizophrenia.

  The Medical letter on drugs and therapeutics 20091102

• Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.

  Molecular psychiatry 20091101

• Ostreolysin induces sustained contraction of porcine coronary arteries and endothelial dysfunction in middle- and large-sized vessels.

  Toxicon : official journal of the International Society on Toxinology 20091101

• Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.

  Prostaglandins & other lipid mediators 20091101

• Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.

  European journal of medicinal chemistry 20091101

• Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives.

  European journal of medicinal chemistry 20091101

• In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.

  The Journal of pharmacology and experimental therapeutics 20091101

• Single- and multiple-dose pharmacokinetics and dose proportionality of the psychotropic agent paliperidone extended release.

  Journal of clinical pharmacology 20091101

• Drug loaded poly[Lac(Glc-Leu)] microparticles: formulation and release characteristics.

  Colloids and surfaces. B, Biointerfaces 20091101

• Antibacterial activity, quantitative structure-activity relationship and diastereoselective synthesis of isoxazolidine derivatives via 1,3-dipolar cycloaddition of d-glucose derived nitrone with olefin.

  Chemical biology & drug design 20091101

• Photodegradation of sulfamethoxazole in various aqueous media: persistence, toxicity and photoproducts assessment.

  Chemosphere 20091101

• Synthesis and biological activity of a new class of sulfone-linked pyrrolylpyrazoles and pyrrolylisoxazoles from methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate.

  Chemical & pharmaceutical bulletin 20091101

• Leflunomide in the treatment of palmoplantar pustulosis.

  Archives of dermatology 20091101

• Bioavailability of diuron, imazapic and isoxaflutole in soils of contrasting textures.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20091101

• 5-Methyl-3-[1-(2-pyridylmeth-yl)-1H-benzimidazol-2-ylmeth-yl]isoxazole.

  Acta crystallographica. Section E, Structure reports online 20091101

• Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20091028

• Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture.

  Archives of orthopaedic and trauma surgery 20091001

• Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathway.

  Annals of the rheumatic diseases 20091001

• Endothelin receptor antagonism and renin inhibition as treatment options for scleroderma kidney.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20091001

• Pharmacological treatment (biotherapy excluded) of peripheral psoriatic arthritis: development of recommendations for clinical practice based on data from the literature and experts opinion.

  Joint, bone, spine : revue du rhumatisme 20091001

• Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20091001

• Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.

  Biochemical pharmacology 20091001

• Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.

  Gastroenterology 20091001

• Paliperidone for treatment of obsessive compulsive resistant symptoms in schizophrenia: a case report.

  Progress in neuro-psychopharmacology & biological psychiatry 20091001

• Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.

  Drug metabolism and disposition: the biological fate of chemicals 20091001

• Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine.

  The Journal of pharmacology and experimental therapeutics 20091001

• Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis.

  Rheumatology (Oxford, England) 20091001

• No pharmacokinetic interaction between paliperidone extended-release tablets and trimethoprim in healthy subjects.

  Human psychopharmacology 20091001

• A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.

  Bioorganic & medicinal chemistry letters 20091001

• Successful treatment of idiopathic orbital inflammatory disease with leflunomide: a case report.

  Southern medical journal 20091001

• Iloperidone: in schizophrenia.

  CNS drugs 20091001

• Independent effect of paliperidone extended release on social functioning beyond its effect on positive and negative symptoms of schizophrenia: a mediation analysis.

  Journal of clinical psychopharmacology 20091001

• The influence of hepatic impairment on the pharmacokinetics of paliperidone.

  International journal of clinical pharmacology and therapeutics 20091001

• Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: a systematic review and economic evaluation.

  Health technology assessment (Winchester, England) 20091001

• 3-(6-Benz-yloxy-2,2-dimethyl-perhydro-furo[2,3-d][1,3]dioxolan-5-yl)-5-(4-chloro-phen-yl)-4-nitro-2-phenyl-2,3,4,5-tetra-hydro-isoxazole.

  Acta crystallographica. Section E, Structure reports online 20091001

• 4-(4-Chloro-phen-yl)-5-phenyl-isoxazole.

  Acta crystallographica. Section E, Structure reports online 20091001

• Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.

  Bioorganic & medicinal chemistry letters 20090915

• Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.

  Bioorganic & medicinal chemistry letters 20090915

• Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities.

  Chemico-biological interactions 20090914

• Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition.

  Biochemistry 20090908

• Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles.

  Organic letters 20090903

• Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.

  Journal of cutaneous pathology 20090901

• The efficacy and safety of leflunomide therapy in lupus nephritis by repeat kidney biopsy.

  Rheumatology international 20090901

• A novel anti-Parkinsonian agent, zonisamide, attenuates MPTP-induced neurotoxicity in mice.

  Journal of molecular neuroscience : MN 20090901

• Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells.

  Tissue engineering. Part A 20090901

• Clinical expression of leflunomide-induced pneumonitis.

  Rheumatology (Oxford, England) 20090901

• Leflunomide-induced interstitial lung disease: prevalence and risk factors in Japanese patients with rheumatoid arthritis.

  Rheumatology (Oxford, England) 20090901

• Determination of risperidone and 9-Hydroxyrisperidone using HPLC, in plasma of children and adolescents with emotional and behavioural disorders.

  Biomedical chromatography : BMC 20090901

• Pharmacokinetics of intramuscular microparticle depot of valdecoxib in an experimental model.

  Drug development and industrial pharmacy 20090901

• Zonisamide enhances delta receptor-associated neurotransmitter release in striato-pallidal pathway.

  Neuropharmacology 20090901

• Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other 'inactivating antagonists'.

  Molecular pharmacology 20090901

• Leflunomide and the lung.

  Rheumatology (Oxford, England) 20090901

• Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice.

  American journal of physiology. Gastrointestinal and liver physiology 20090901

• New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.

  Bioorganic & medicinal chemistry letters 20090901

• The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?

  Epilepsia 20090901

• Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy: preliminary report.

  Acta neurologica Scandinavica 20090901

• Safety and tolerability of deltoid and gluteal injections of paliperidone palmitate in schizophrenia.

  Progress in neuro-psychopharmacology & biological psychiatry 20090831

• Ampakine therapy to counter fentanyl-induced respiratory depression.

  Respiratory physiology & neurobiology 20090831

• Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib.

  Brain research bulletin 20090828

• 3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity.

  Journal of agricultural and food chemistry 20090826

• Theoretical investigations of the photochemical isomerizations of indoxazene and isoxazole.

  The Journal of organic chemistry 20090821

• FXR agonist activity of conformationally constrained analogs of GW 4064.

  Bioorganic & medicinal chemistry letters 20090815

• Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.

  Bioorganic & medicinal chemistry letters 20090815

• Time resolved analysis of risperidone and 9-hydroxy-risperidone in hair using LC/MS-MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815

• C5-Modified nucleosides exhibiting anticancer activity.

  Bioorganic & medicinal chemistry letters 20090815

• Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.

  Molecular psychiatry 20090801

• Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus.

  Glia 20090801

• Parecoxib and indomethacin delay early fracture healing: a study in rats.

  Clinical orthopaedics and related research 20090801

• A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients.

  Sleep medicine 20090801

• An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.

  Molecular pharmacology 20090801

• Successful treatment of multicentric reticulohistiocytosis with leflunomide.

  The British journal of dermatology 20090801

• Polyoma BK virus-associated nephropathy in kidney-transplant patients: Effects of leflunomide on T-cell functions and disease outcome.

  International immunopharmacology 20090801

• Pharmacokinetics and efficacy of a direct switch from conventional depot to risperidone long-acting injection in Chinese patients with schizophrenic and schizoaffective disorders.

  Psychiatry and clinical neurosciences 20090801

• Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor.

  Experimental biology and medicine (Maywood, N.J.) 20090801

• Leflunomide use in renal transplantation.

  Current opinion in organ transplantation 20090801

• Serum levels of risperidone and its metabolite, 9-hydroxyrisperidone: correlation between drug concentration and clinical response.

  Therapeutic drug monitoring 20090801

• Paliperidone extended-release for schizophrenia: effects on symptoms and functioning in acutely ill patients with negative symptoms.

  Schizophrenia research 20090801

• A systematic MEDLINE analysis of therapeutic approaches in ankylosing spondylitis.

  Rheumatology international 20090801

• The regulatory effect of the p38 signaling pathway on valdecoxib-induced apoptosis of the Eca109 cell line.

  Oncology reports 20090801

• Zonisamide: in Parkinson's disease.

  CNS drugs 20090801

• Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan.

  British journal of pharmacology 20090801

• Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis.

  Annals of the rheumatic diseases 20090801

• Iloperidone for schizophrenia: a review of the efficacy and safety profile for this newly commercialised second-generation antipsychotic.

  International journal of clinical practice 20090801

• Lysophosphatidic Acid signals through specific lysophosphatidic Acid receptor subtypes to control key regenerative responses of human gingival and periodontal ligament fibroblasts.

  Journal of periodontology 20090801

• Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station.

  Assay and drug development technologies 20090801

• Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells.

  Respirology (Carlton, Vic.) 20090801

• Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.

  Neurophysiologie clinique = Clinical neurophysiology 20090801

• [Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension].

  Deutsche medizinische Wochenschrift (1946) 20090801

• Immunosuppressants: JC virus encephalopathy. Rare but fatal.

  Prescrire international 20090801

• Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.

  Bioorganic & medicinal chemistry 20090715

• Danazol for uterine fibroids.

  The Cochrane database of systematic reviews 20090708

• Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity.

  Brain research 20090707

• Synthesis of the isoxazolo[4,3,2-de]phenanthridinone moiety of the parnafungins.

  Organic letters 20090702

• Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance.

  Annals of the rheumatic diseases 20090701

• Negative effects of parecoxib and indomethacin on tendon healing: an experimental study in rats.

  Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20090701

• Role of sorption and degradation in the herbicidal function of isoxaflutole.

  Pest management science 20090701

• Simultaneous estimation of four proton pump inhibitors--lansoprazole, omeprazole, pantoprazole and rabeprazole: development of a novel generic HPLC-UV method and its application to clinical pharmacokinetic study.

  Biomedical chromatography : BMC 20090701

• Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).

  Drug metabolism and disposition: the biological fate of chemicals 20090701

• Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20090701

• Impact of psychotic relapse definitions in assessing drug efficacy and costs: comparison of quetiapine XR, olanzapine and paliperidone ER.

  Current medical research and opinion 20090701

• Synthesis and antinociceptive activity of pyrazolyl isoxazolines and pyrazolyl isoxazoles.

  Bioorganic & medicinal chemistry letters 20090701

• Management of RA medications in pregnant patients.

  Nature reviews. Rheumatology 20090701

• [The role of the neuromodulators in the preventive treatment of migraine].

  Revista de neurologia 20090701

• Efficacy of subacromial ropivacaine infusion for rotator cuff surgery. A randomized trial.

  The Journal of bone and joint surgery. American volume 20090701

• The effects of paroxetine on the pharmacokinetics of paliperidone extended-release tablets.

  Pharmacopsychiatry 20090701

• [A clinical study of leflunomide and methotrexate therapy in psoriatic arthritis].

  Zhonghua nei ke za zhi 20090701

• 1-(3-Phenyl-isoxazol-5-yl)cyclo-hexane-1,2-diol.

  Acta crystallographica. Section E, Structure reports online 20090701

• N-Phenyl-4-(8-phenyl-4,5-dihydro-1,2-benzoxazolo[4,5-d]thia-zol-2-yl)piperidine-1-carboxamide.

  Acta crystallographica. Section E, Structure reports online 20090701

• Simple conversion of enamines to 2H-azirines and their rearrangements under thermal conditions.

  Organic letters 20090618

• Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine.

  Biological psychiatry 20090615

• Stability of zonisamide in extemporaneously compounded oral suspensions.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090615

• Providing patients with information about disease-modifying anti-rheumatic drugs: Individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction.

  Musculoskeletal care 20090601

• Preliminary study on the immunologic background of good clinical outcome in rheumatoid arthritis patients after one month therapy with leflunomide.

  Rheumatology international 20090601

• Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress.

  Psychopharmacology 20090601

• The behavior of clomazone in the soil environment.

  Pest management science 20090601

• Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension.

  European journal of clinical investigation 20090601

• A review of STRIDE-2 and STRIDE-2X: the case for selective endothelin receptor blockade.

  European journal of clinical investigation 20090601

• Effects of the CYP2D6*10 alleles and co-medication with CYP2D6-dependent drugs on risperidone metabolism in patients with schizophrenia.

  Human psychopharmacology 20090601

• Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.

  Bioorganic & medicinal chemistry letters 20090601

• Randomized, double-blind, placebo-controlled study of paliperidone extended-release and quetiapine in inpatients with recently exacerbated schizophrenia.

  The American journal of psychiatry 20090601

• Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.

  Bioorganic & medicinal chemistry letters 20090601

• Effects of CYP2D6 and CYP3A5 genotypes on the plasma concentrations of risperidone and 9-hydroxyrisperidone in Korean schizophrenic patients.

  Journal of clinical psychopharmacology 20090601

• Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.

  European journal of gastroenterology & hepatology 20090601

• Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion.

  Journal of cardiovascular pharmacology 20090601

• Successful up-front combination therapy in a patient with idiopathic pulmonary hypertension and patent foramen ovale: an alternative to epoprostenol therapy?

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090601

• Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy.

  The European respiratory journal 20090601

• Sensitization of human hepatic stellate cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by leflunomide.

  Biological & pharmaceutical bulletin 20090601

• Newer therapies for vasculitis.

  Best practice & research. Clinical rheumatology 20090601

• Small-molecule endothelin receptor antagonists: a review of patenting activity across therapeutic areas.

  IDrugs : the investigational drugs journal 20090601

• Cutaneous ulceration induced by leflunomide in a psoriatic patient.

  International journal of dermatology 20090601

• The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells.

  Transplantation proceedings 20090601

• Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia.

  The Journal of clinical psychiatry 20090601

• Synthesis and immunomodulation of human lymphocyte proliferation and cytokine (interferon-gamma) production of four novel malonitrilamides.

  Chemical biology & drug design 20090601

• Bioequivalence of zonisamide orally dispersible tablet and immediate-release capsule formulations: results from two open-label, randomized-sequence, single-dose, two-period, two-treatment crossover studies in healthy male volunteers.

  Clinical therapeutics 20090601

• 3-(10-Chloro-9-anthr-yl)-5-[3-(prop-2-yn-yloxy)phenoxy-meth-yl]isoxazole.

  Acta crystallographica. Section E, Structure reports online 20090601

• Paliperidone suppresses the development of the aggressive phenotype in a developmentally sensitive animal model of escalated aggression.

  Psychopharmacology 20090501

• Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial.

  International journal of colorectal disease 20090501

• Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.

  American journal of physiology. Gastrointestinal and liver physiology 20090501

• Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.

  The Journal of antimicrobial chemotherapy 20090501

• Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABAA receptor.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090501

• Natural impacted freshwaters: in situ use of alginate immobilized algae to the assessment of algal response.

  Ecotoxicology (London, England) 20090501

• Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.

  Bioorganic & medicinal chemistry letters 20090501

• Akathisia and second-generation antipsychotic drugs.

  Current opinion in psychiatry 20090501

• Progressive multifocal leukoencephalopathy, a review and an extended report of five patients with different immune compromised states.

  European journal of internal medicine 20090501

• Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP.

  Journal of pharmacological sciences 20090501

• PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.

  Archives of pharmacal research 20090501

• The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning.

  The Spanish journal of psychology 20090501

• Possible mechanism for zonisamide-induced hyperammonemia in a child with citrullinemia type 1.

  Indian journal of medical sciences 20090501

• 4-(4-Methoxy-phen-yl)-3-methyl-1,6-di-oxa-2,8-diaza-s-indacen-5(7H)-one.

  Acta crystallographica. Section E, Structure reports online 20090501

• 3-(6-Benz-yloxy-2,2-dimethyl-perhydro-furo[2,3-d][1,3]dioxol-5-yl)-5-(4-bromo-phen-yl)-2-phenyl-perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione.

  Acta crystallographica. Section E, Structure reports online 20090501

• Efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy: a prospective, randomized study.

  World journal of gastroenterology 20090428

• Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors.

  Neuroscience letters 20090417

• Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique.

  Journal of neuroscience methods 20090415

• Intravenous or intramuscular parecoxib for acute postoperative pain in adults.

  The Cochrane database of systematic reviews 20090415

• Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis.

  Life sciences 20090410

• Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis.

  Journal of medicinal chemistry 20090409

• The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.

  Endocrinology 20090401

• Secondary delusional parasitosis treated with paliperidone.

  Clinical and experimental dermatology 20090401

• Influence of parecoxib (cox-2 inhibitor) in experimental pleurodesis.

  Respiratory medicine 20090401

• The impact of zonisamide on weight. A clinical study in 103 patients with epilepsy.

  Acta neurologica Scandinavica 20090401

• [Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study].

  Schmerz (Berlin, Germany) 20090401

• An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment.

  Clinical pharmacology and therapeutics 20090401

• Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide.

  American journal of physiology. Renal physiology 20090401

• Inhibiting the teratogenicity of the immunosuppressant leflunomide in mice by supplementation of exogenous uridine.

  Toxicological sciences : an official journal of the Society of Toxicology 20090401

• [New antiepileptic drugs].

  La Revue de medecine interne 20090401

• Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist.

  Journal of neurochemistry 20090401

• Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.

  British journal of pharmacology 20090401

• A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis.

  European journal of pharmacology 20090401

• Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin.

  Epilepsy research 20090401

• Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake.

  Nuclear medicine and biology 20090401

• Improved myocardial protection in the failing heart by selective endothelin-A receptor blockade.

  The Journal of thoracic and cardiovascular surgery 20090401

• An elderly man with rheumatoid arthritis and dyspnea.

  Chest 20090401

• [Leflunomide and Lyell syndrome].

  Annales de dermatologie et de venereologie 20090401

• [Pharmacologic treatment of Parkinson disease].

  Brain and nerve = Shinkei kenkyu no shinpo 20090401

• A 50-year-old man with stage 2 sarcoidosis with pleural involvement.

  Journal of hospital medicine 20090401

• The effects of PDTC plus leflunomide and cyclosporine on the NF-kappaB signaling pathway in mouse-to-rat cardiac xenografts.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090401

• Dimethyl cis-2-methyl-3-p-tolyl-isoxazolidine-4,5-dicarboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090401

• 2-Methyl-3-(5-methyl-2-thien-yl)-5-phenyl-perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione.

  Acta crystallographica. Section E, Structure reports online 20090401

• 5-(1-Cyclo-hexen-1-yl)-3-(4-methoxy-phen-yl)isoxazole.

  Acta crystallographica. Section E, Structure reports online 20090401

• Crystal structure of acivicin-inhibited gamma-glutamyltranspeptidase reveals critical roles for its C-terminus in autoprocessing and catalysis.

  Biochemistry 20090324

• Synthesis and herbicidal activities of novel 4-(4-(5-methyl-3-arylisoxazol-4-yl)thiazol-2-yl)piperidyl carboxamides and thiocarboxamides.

  Molecules (Basel, Switzerland) 20090324

• The versatile electrophilic reactivity of 4,6-dinitrobenzo[d]isoxazole-3-carbonitrile.

  Organic & biomolecular chemistry 20090321

• TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells.

  Circulation research 20090313

• Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles.

  Journal of combinatorial chemistry 20090309

• Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension.

  Journal of the American College of Cardiology 20090303

• Progress in the discovery of selective, high affinity A(2B) adenosine receptor antagonists as clinical candidates.

  Purinergic signalling 20090301

• Selective P2X(7) receptor antagonists for chronic inflammation and pain.

  Purinergic signalling 20090301

• Case-control analysis of ambulance, emergency room, or inpatient hospital events for epilepsy and antiepileptic drug formulation changes.

  Epilepsia 20090301

• Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

  European journal of medicinal chemistry 20090301

• Identification of steroid isoxazole isomers marketed as designer supplement.

  Steroids 20090301

• LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.

  Carcinogenesis 20090301

• [Leg ulcer in mixed connective tissue disease. Resolution during sitaxsentan therapy].

  Zeitschrift fur Rheumatologie 20090301

• [Leflunomide in combination with TNF-blockers for Methotrexate intolerance].

  Zeitschrift fur Rheumatologie 20090301

• Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein.

  International journal of molecular medicine 20090301

• Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20090301

• Critical periods for the teratogenicity of immune-suppressant Leflunomide in mice.

  Congenital anomalies 20090301

• Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide.

  Arthritis and rheumatism 20090301

• [Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis].

  Clinical calcium 20090301

• Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy.

  Epileptic disorders : international epilepsy journal with videotape 20090301

• [Immunosuppressants].

  Nihon rinsho. Japanese journal of clinical medicine 20090301

• Increased prevalence of polyomavirus BK viruria that correlates with thrombocytopenia in patients with systemic lupus erythematosus on intensive immunosuppressive therapy.

  Autoimmunity 20090301

• Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.

  The European journal of neuroscience 20090301

• Paliperidone in an adult patient with Asperger syndrome: case report.

  Pharmacopsychiatry 20090301

• Expected clinical benefits of paliperidone extended-release formulation when compared with risperidone immediate-release.

  Expert opinion on drug delivery 20090301

• Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795.

  Neuropharmacology 20090301

• [Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia].

  Biomedica : revista del Instituto Nacional de Salud 20090301

• Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology.

  Journal of neuroscience methods 20090215

• Zonisamide for essential tremor: an evaluator-blinded study.

  Movement disorders : official journal of the Movement Disorder Society 20090215

• Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

  Bioorganic & medicinal chemistry letters 20090215

• Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugates.

  Bioorganic & medicinal chemistry 20090215

• ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.

  Bioorganic & medicinal chemistry 20090201

• Expanding the repertoire of small molecule transcriptional activation domains.

  Bioorganic & medicinal chemistry 20090201

• Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein.

  American journal of respiratory cell and molecular biology 20090201

• Ultrasound promoted synthesis of substituted pyrazoles and isoxazoles containing sulphone moiety.

  Ultrasonics sonochemistry 20090201

• COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex.

  Kidney international 20090201

• Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists.

  Molecular pharmacology 20090201

• Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.

  The Journal of pharmacology and experimental therapeutics 20090201

• Local and global calcium signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors.

  Cell calcium 20090201

• Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression.

  Carcinogenesis 20090201

• Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study.

  Epilepsy research 20090201

• Metabolism and renal elimination of gaboxadol in humans: role of UDP-glucuronosyltransferases and transporters.

  Pharmaceutical research 20090201

• Tolerability, pharmacokinetics and night-time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects.

  British journal of clinical pharmacology 20090201

• Zonisamide block of cloned human T-type voltage-gated calcium channels.

  Epilepsy research 20090201

• Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20090201

• Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells.

  Molecular cancer therapeutics 20090201

• Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease.

  Arthritis and rheumatism 20090201

• Disease-modifying antirheumatic drugs.

  The Journal of hand surgery 20090201

• The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats.

  The Journal of bone and joint surgery. British volume 20090201

• Reliability, validity and ability to detect change of the clinician-rated Personal and Social Performance scale in patients with acute symptoms of schizophrenia.

  Current medical research and opinion 20090201

• Bioequivalence evaluation of two strengths of risperidone tablet formulations in healthy volunteers.

  International journal of clinical pharmacology and therapeutics 20090201

• The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide.

  Pharmacogenomics 20090201

• Leflunomide use in New Zealand. A national prospective post-marketing study.

  Internal medicine journal 20090201

• Pharmacology of alpha7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells.

  British journal of pharmacology 20090201

• New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations.

  Chemistry & biodiversity 20090201

• In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic.

  Journal of health, population, and nutrition 20090201

• Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer.

  Annals of the New York Academy of Sciences 20090201

• Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade.

  Therapeutic advances in respiratory disease 20090201

• [Psychiatry].

  Revue medicale suisse 20090114

• The effectiveness of leflunomide as a co-therapy of tumour necrosis factor inhibitors in rheumatoid arthritis: a population-based study.

  Annals of the rheumatic diseases 20090101

• Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy.

  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20090101

• The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.

  The Journal of surgical research 20090101

• The changes in serum chemokines following leflunomide therapy in patients with rheumatoid arthritis.

  Clinical rheumatology 20090101

• Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.

  Parkinsonism & related disorders 20090101

• Effects of leflunomide and methotrexate in rheumatoid arthritis detected by digital X-ray radiogrammetry and computer-aided joint space analysis.

  Rheumatology international 20090101

• Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities.

  Chest 20090101

• Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus.

  Reproduction (Cambridge, England) 20090101

• New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.

  Antiviral research 20090101

• Zonisamide for migraine prophylaxis in patients refractory to topiramate.

  Clinical neuropharmacology 20090101

• Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717.

  Psychopharmacology 20090101

• Next-day residual effects of gaboxadol and flurazepam administered at bedtime: a randomized double-blind study in healthy elderly subjects.

  Human psychopharmacology 20090101

• Macrophage migration inhibitory factor promotes colorectal cancer.

  Molecular medicine (Cambridge, Mass.) 20090101

• The new immunosuppressive agent FK778 attenuates neointima formation in an experimental venous bypass graft model.

  Vascular pharmacology 20090101

• Chronic stimulation of farnesoid X receptor impairs nitric oxide sensitivity of vascular smooth muscle.

  American journal of physiology. Heart and circulatory physiology 20090101

• Synthesis and evaluation of electron-rich curcumin analogues.

  Bioorganic & medicinal chemistry 20090101

• Parecoxib for analgesia after craniotomy.

  British journal of anaesthesia 20090101

• Photoinduced degradation of the herbicide clomazone model reactions for natural and technical systems.

  Photochemistry and photobiology 20090101

• Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus.

  The European journal of neuroscience 20090101

• Update on medication-induced peripheral neuropathy.

  Current neurology and neuroscience reports 20090101

• Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

  Hepatology (Baltimore, Md.) 20090101

• Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting: an analysis of integrated data.

  Anesthesia and analgesia 20090101

• Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs.

  Veterinary anaesthesia and analgesia 20090101

• Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression.

  Biological & pharmaceutical bulletin 20090101

• Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis.

  Scandinavian journal of rheumatology 20090101

• The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro.

  Modern rheumatology 20090101

• Synthesis of some new isoxazoline derivatives as possible anti-Candida agents.

  Acta poloniae pharmaceutica 20090101

• [Synthesis of electroconductive polyaniline using immobilized laccase].

  Prikladnaia biokhimiia i mikrobiologiia 20090101

• [Role of monotherapy with new antiepileptic drugs in the treatment of childhood epilepsy].

  Medicina 20090101

• A randomized, double-blind, placebo-controlled study of preemptively administered intravenous parecoxib: effect on anxiety levels and procedural pain during epidural catheter placement for surgical operations or for chronic pain therapy.

  Pain practice : the official journal of World Institute of Pain 20090101

• Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients.

  Journal of autoimmunity 20090101

• Double-blind, placebo-controlled, multiple-ascending-dose study on the pharmacodynamics of ABIO-08/01, a new CNS drug with potential anxiolytic activity. 2. EEG-tomography findings based on LORETA (low-resolution brain electromagnetic tomography).

  Neuropsychobiology 20090101

• Treatment of Evans' syndrome with human intravenous immunoglobulin and leflunomide in a diabetic dog.

  Journal of the American Animal Hospital Association 20090101

• Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.

  Pharmacology 20090101

• IL-1beta, IL-6, and TNF gene polymorphisms do not affect the treatment outcome of rheumatoid arthritis patients with leflunomide.

  Pharmacological reports : PR 20090101

• Efficient synthesis of trisubstituted pyrazoles and isoxazoles using a traceless 'catch and release' solid-phase strategy.

  Journal of combinatorial chemistry 20090101

• The effect of parecoxib on kidney function at laparoscopic hysterectomy.

  Renal failure 20090101

• Development of mucoadhesive buccal films for the treatment of oral sub-mucous fibrosis: a preliminary study.

  Pharmaceutical development and technology 20090101

• Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis.

  International journal of medical sciences 20090101

• Leflunomide-induced polymyositis in a patient with rheumatoid arthritis.

  Modern rheumatology 20090101

• FK778 attenuates cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model.

  Intervirology 20090101

• Leflunomide treatment in elderly patients with rheumatoid or psoriatic arthritis: retrospective analysis of safety and adherence to treatment.

  Drugs & aging 20090101

• Oral therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis.

  Applied health economics and health policy 20090101

• Leflunomide.

  Indian journal of dermatology, venereology and leprology 20090101

• Long-term efficacy of leflunomide on disease activity and inhibition of joint damage: retrospective comparison with methotrexate for Japanese rheumatoid arthritis patients.

  Modern rheumatology 20090101

• The anticonvulsant zonisamide reduces ethanol self-administration by risky drinkers.

  The American journal of drug and alcohol abuse 20090101

• Idiopathic hemifacial spasm responsive to zonisamide: a case report.

  Clinical neuropharmacology 20090101

• Base induced chemical conversion of 3-carbamoyl-2-isoxazolines.

  Journal of oleo science 20090101

• [Rituximab treatment of rheumatoid arthritis: new evidence].

  Terapevticheskii arkhiv 20090101

• Reduction in opioid-related adverse events and improvement in function with parecoxib followed by valdecoxib treatment after non-cardiac surgery: a randomized, double-blind, placebo-controlled, parallel-group trial.

  Clinical drug investigation 20090101

• Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus.

  BMC microbiology 20090101

• Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of rejection.

  Transplantation proceedings 20090101

• Identification of the specific binding proteins of bioactive small compound using affinity resins.

  Methods in molecular biology (Clifton, N.J.) 20090101

• Population pharmacokinetics of intramuscular paliperidone palmitate in patients with schizophrenia: a novel once-monthly, long-acting formulation of an atypical antipsychotic.

  Clinical pharmacokinetics 20090101

• Paliperidon mediated modification of cortical inhibition.

  Neuro endocrinology letters 20090101

• Benefit-risk assessment of leflunomide: an appraisal of leflunomide in rheumatoid arthritis 10 years after licensing.

  Drug safety 20090101

• Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia.

  Acta virologica 20090101

• Antipsychotic induced catatonia: a case of probable dementia with Lewy bodies.

  The Journal of neuropsychiatry and clinical neurosciences 20090101

• [Treatment with paliperidone extended-release tablets in a case of resistant undifferentiated schizophrenia: clinical improvement with 12 mg and evaluation through 3TRE scale].

  Rivista di psichiatria 20090101

• The economic burden of biological therapy in rheumatoid arthritis in clinical practice: cost-effectiveness analysis of sub-cutaneous anti-TNFalpha treatment in Italian patients.

  International journal of immunopathology and pharmacology 20090101

• A comprehensive review of immunosuppression used for liver transplantation.

  Journal of transplantation 20090101

• The influence of agonists of GABA(A) and GABA(B) receptors on the formation of the defensive and inhibitory conditioned reflexes.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101

• [Lichen planus-like eruption. Case report].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20090101

• DPRESS: Localizing estimates of predictive uncertainty.

  Journal of cheminformatics 20090101

• Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles.

  Indian journal of pharmaceutical sciences 20090101

• [Systematic review to assess the effectiveness and safety of parecoxib].

  Acta ortopedica mexicana 20090101

• Pregnancy course and neonatal outcome after exposure to leflunomide--2 cases report and review of literature.

  Przeglad lekarski 20090101

• Ethyl 4-{1-[(2,4-dinitro-phen-yl)hydrazono]eth-yl}-5-(2-naphthyl-methoxy-meth-yl)isoxazole-3-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090101

• Suppression of immunoglobulin production by a novel dihydroorotate dehydrogenase inhibitor, S-2678.

  European journal of pharmacology 20081228

• Study of the complexation of risperidone and 9-hydroxyrisperidone with cyclodextrin hosts using affinity capillary electrophoresis and (1)H NMR spectroscopy.

  Journal of chromatography. A 20081226

• Click azide-nitrile cycloaddition as a new ligation tool for the synthesis of tetrazole-tethered C-glycosyl alpha-amino acids.

  The Journal of organic chemistry 20081219

• Sequential organocatalyzed Michael addition/[3 + 2]-heterocyclization for the stereoselective synthesis of fused-isoxazoline precursors of enantiopure cyclopentanoids.

  Organic letters 20081204

• Cyclooxygenase 2 pathway and its therapeutic inhibition in superantigen-induced toxic shock.

  Shock (Augusta, Ga.) 20081201

• [Zonisamide as add-on treatment for focal epilepsies. An outcome analysis of 74 patients].

  Der Nervenarzt 20081201

• Predicting possible zonisamide hypersensitivity syndrome.

  Experimental dermatology 20081201

• Temperature and water pressure head effects on the degradation of the diketonitrile metabolite of isoxaflutole in a loamy soil under two tillage systems.

  Environmental pollution (Barking, Essex : 1987) 20081201

• Rheumatoid arthritis, alcohol, leflunomide and methotrexate. Can changes to the BSR guidelines for leflunomide and methotrexate on alcohol consumption be justified?

  Musculoskeletal care 20081201

• Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain.

  The Journal of pharmacology and experimental therapeutics 20081201

• COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.

  Prostaglandins, leukotrienes, and essential fatty acids 20081201

• Biochemical effects of clomazone herbicide on piava (Leporinus obtusidens).

  Chemosphere 20081201

• Disposition and safety of zonisamide after intravenous and oral single dose and oral multiple dosing in normal hound dogs.

  Journal of veterinary pharmacology and therapeutics 20081201

• The disparity of pharmacokinetics and prolactin study for risperidone long-acting injection.

  Journal of clinical psychopharmacology 20081201

• What are the nursing implications when using paliperidone prolonged release for people with schizophrenia.

  Journal of psychiatric and mental health nursing 20081201

• DMARDS and infections in rheumatoid arthritis.

  Autoimmunity reviews 20081201

• A pair of twins born after maternal exposure to leflunomide.

  Journal of perinatology : official journal of the California Perinatal Association 20081201

• Is leflunomide effective in the treatment of psoriasis in a patient who is unable to benefit from standard first- and second-line therapies and needs an affordable treatment option?

  Archives of dermatology 20081201

• The reaction of beta-amino-alpha,gamma-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities.

  Acta pharmaceutica (Zagreb, Croatia) 20081201

• The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis.

  Diabetes & metabolism 20081201

• [Update in treatment of psoriatic arthritis].

  La Tunisie medicale 20081201

• Catalytic mechanism and performance of computationally designed enzymes for Kemp elimination.

  Journal of the American Chemical Society 20081126

• Apparent seizure and atrial fibrillation associated with paliperidone.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081115

• Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081101

• Synthesis and pharmacological screening of derivatives of isoxazolo[4,5-d]pyrimidine.

  European journal of medicinal chemistry 20081101

• Coexistence of familial Mediterranean fever and psoriasis in a patient with seronegative spondyloarthropathy.

  Rheumatology international 20081101

• FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081101

• Treatment emergent mania responding to valproate in a Chinese female adolescent population with eating disorders: a case series.

  European eating disorders review : the journal of the Eating Disorders Association 20081101

• Tissue transgluaminase 2 expression in meningiomas.

  Journal of neuro-oncology 20081101

• Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors.

  The Journal of pharmacology and experimental therapeutics 20081101

• Effects of zonisamide on isolated head tremor.

  European journal of neurology 20081101

• Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.

  Epilepsy research 20081101

• Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study.

  British journal of clinical pharmacology 20081101

• The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis.

  Journal of hepatology 20081101

• Efficacy and safety of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 52-week open-label studies.

  International clinical psychopharmacology 20081101

• Use of leflunomide in the treatment of polyomavirus BK-associated nephropathy.

  The Annals of pharmacotherapy 20081101

• [Preventive treatment of chronic migraine with zonisamide: a study in patients who are refractory or intolerant to topiramate].

  Revista de neurologia 20081101

• Leflunomide-associated progressive multifocal leukoencephalopathy.

  Archives of neurology 20081101

• Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation.

  Die Pharmazie 20081101

• [Therapy of Parkinson's disease--up to date].

  Rinsho shinkeigaku = Clinical neurology 20081101

• Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase.

  The Journal of biological chemistry 20081024

• 3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.

  Journal of medicinal chemistry 20081023

• Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.

  Journal of medicinal chemistry 20081023

• [Antirheumatic agents for treatment of rheumatoid arthritis].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20081010

• Paliperidone as a mood stabilizer: a pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression.

  Brain research 20081003

• Responses to clomazone and 5-ketoclomazone by Echinochloa phyllopogon resistant to multiple herbicides in Californian rice fields.

  Pest management science 20081001

• NMR studies of novel Schiff bases derived from L-alpha-amino methyl esters and 3-hydroxypyridin-4-carboxaldehyde.

  Magnetic resonance in chemistry : MRC 20081001

• Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survival.

  Chest 20081001

• ABCB1 polymorphisms influence steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety.

  Therapeutic drug monitoring 20081001

• Impact of multiple inhibitors or substrates of cytochrome P450 2D6 on plasma risperidone levels in patients on polypharmacy.

  Therapeutic drug monitoring 20081001

• Novel immunological approaches in the treatment of atopic eczema.

  Current opinion in allergy and clinical immunology 20081001

• Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.

  Bioorganic & medicinal chemistry letters 20081001

• Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20081001

• Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.

  Joint, bone, spine : revue du rhumatisme 20081001

• [Specific drugs for the treatment of pulmonary arterial hypertension - current status].

  Deutsche medizinische Wochenschrift (1946) 20081001

• Paliperidone extended-release for the treatment of schizophrenia.

  Pharmacotherapy 20081001

• Effect of gaboxadol on sleep in adult and elderly patients with primary insomnia: results from two randomized, placebo-controlled, 30-night polysomnography studies.

  Sleep 20081001

• Treatment of seizures in a patient with Batten's disease.

  The Nurse practitioner 20081001

• Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension.

  Vascular health and risk management 20081001

• Intermolecular cycloaddition of N-boranonitrone with alkenes.

  The Journal of organic chemistry 20080919

• Proline as Lewis base catalyst: diastereoselective synthesis of isoxazoline-N-oxide through [3 + 2] cycloaddition.

  Organic letters 20080918

• Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.

  Bioorganic & medicinal chemistry letters 20080915

• A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.

  Cancer research 20080915

• Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells.

  Biochemical and biophysical research communications 20080912

• Selective ortho methylation of nitroheteroaryls by vicarious nucleophilic substitution.

  The Journal of organic chemistry 20080905

• Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080902

• Introducing the first polymer-free leflunomide eluting stent.

  Atherosclerosis 20080901

• Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.

  Immunology 20080901

• A prospective, randomized, double-blind comparison between parecoxib and ketorolac for early postoperative analgesia following nasal surgery.

  Minerva anestesiologica 20080901

• [Elevated liver enzymes in rheumatoid arthritis : differential diagnostic considerations based on a case report].

  Zeitschrift fur Rheumatologie 20080901

• Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients.

  European journal of clinical pharmacology 20080901

• Adjunctive anakinra in patients with active rheumatoid arthritis despite methotrexate, or leflunomide, or cyclosporin-A monotherapy: a 48-week, comparative, prospective study.

  Rheumatology (Oxford, England) 20080901

• Tolerability of methotrexate and leflunomide combination therapy for inflammatory arthritis in routine clinical practice: results of a four-centre study.

  Rheumatology (Oxford, England) 20080901

• The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury.

  The Tohoku journal of experimental medicine 20080901

• Choreatic symptoms during and after treatment with paliperidone and escitalopram.

  Pharmacopsychiatry 20080901

• Therapeutic role of zonisamide in neuropsychiatric disorders.

  Mini reviews in medicinal chemistry 20080901

• Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.

  Toxicology letters 20080828

• [Paliperidone--a novel second-generation antipsychotic].

  Ugeskrift for laeger 20080825

• Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.

  Bioorganic & medicinal chemistry letters 20080815

• Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.

  Bioorganic & medicinal chemistry letters 20080815

• Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties.

  Journal of medicinal chemistry 20080814

• Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.

  Journal of medicinal chemistry 20080814

• Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells.

  Rheumatology international 20080801

• Pharmacokinetics and toxicity of zonisamide in cats.

  Journal of feline medicine and surgery 20080801

• Leflunomide (Arava) is a useful DMARD in Indian (Asian) patients: a clinic-based observational study of 1-year treatment.

  Clinical rheumatology 20080801

• Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity.

  American journal of physiology. Cell physiology 20080801

• Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma.

  Leukemia 20080801

• Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.

  Journal of neurophysiology 20080801

• Does leflunomide attenuate the sepsis-induced acute lung injury?

  Pediatric surgery international 20080801

• Approaches to the treatment of early rheumatoid arthritis with disease-modifying antirheumatic drugs.

  British journal of clinical pharmacology 20080801

• Long-term safety and efficacy of zonisamide in patients with refractory partial-onset epilepsy.

  Acta neurologica Scandinavica 20080801

• Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?

  European heart journal 20080801

• Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

  Bioorganic & medicinal chemistry letters 20080801

• A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty.

  Anesthesia and analgesia 20080801

• Population estimation regarding the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance.

  Therapeutic drug monitoring 20080801

• Targeting Hsp90: small-molecule inhibitors and their clinical development.

  Current opinion in pharmacology 20080801

• [Persistent diarrhea and loss of weight during therapy with leflunomide].

  Deutsche medizinische Wochenschrift (1946) 20080801

• Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.

  Cancer science 20080801

• Severe crescentic BK virus nephropathy with favourable outcome in a transplanted patient treated with Leflunomide.

  Clinical nephrology 20080801

• Sitaxsentan sodium for pulmonary hypertension.

  Drugs of today (Barcelona, Spain : 1998) 20080801

• Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726.

  Drug metabolism letters 20080801

• (3R,3aS,6aR)-2,5-Dimethyl-3-(5-phenyl-2-thien-yl)perhydro-pyrrolo[3,4-d][1,2]oxazole-4,6-dione.

  Acta crystallographica. Section E, Structure reports online 20080801

• Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.

  Biochemical and biophysical research communications 20080718

• Synthesis of alpha-trifluoromethyl-beta-lactams and esters of beta-amino acids via 1,3-dipolar cycloaddition of nitrones to fluoroalkenes.

  The Journal of organic chemistry 20080718

• Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.

  Bioorganic & medicinal chemistry 20080715

• Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol.

  Neuroscience letters 20080711

• One-pot synthesis of highly functionalized pyridines via a rhodium carbenoid induced ring expansion of isoxazoles.

  Journal of the American Chemical Society 20080709

• Fungicidal effect and the mode of action of piscidin 2 derived from hybrid striped bass.

  Biochemical and biophysical research communications 20080704

• Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists.

  Journal of molecular biology 20080704

• Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.

  Pharmacology, biochemistry, and behavior 20080701

• The use of voltage-sensitive dyes to monitor signal-induced changes in membrane potential-ABA triggered membrane depolarization in guard cells.

  The Plant journal : for cell and molecular biology 20080701

• Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures.

  Epilepsy research 20080701

• Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex.

  Journal of neurophysiology 20080701

• Exacerbation of Whipple disease by immunosuppressants.

  Journal of clinical gastroenterology 20080701

• Effects of a non-selective COX inhibitor and selective COX-2 inhibitors on contractility of human and porcine ureters in vitro and in vivo.

  British journal of pharmacology 20080701

• Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix.

  Rapid communications in mass spectrometry : RCM 20080701

• Paliperidone extended-release tablets in schizophrenia patients previously treated with risperidone.

  International clinical psychopharmacology 20080701

• Modeling spheroid growth, PET tracer uptake, and treatment effects of the Hsp90 inhibitor NVP-AUY922.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701

• Small-molecule activation of neuronal cell fate.

  Nature chemical biology 20080701

• Validated LC-MS/MS methods for the determination of risperidone and the enantiomers of 9-hydroxyrisperidone in human plasma and urine.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080701

• Zonisamide concentrations during pregnancy.

  The Annals of pharmacotherapy 20080701

• Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study.

  Lupus 20080701

• Comparison of parecoxib and proparacetamol in endoscopic nasal surgery patients.

  Yonsei medical journal 20080630

• Macrophage migration inhibitory factor induces cardiomyocyte apoptosis.

  Biochemical and biophysical research communications 20080627

• Synthesis and biological evaluation of D-amino acid oxidase inhibitors.

  Journal of medicinal chemistry 20080626

• Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library.

  Journal of medicinal chemistry 20080626

• Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.

  The Journal of biological chemistry 20080613

• A systematic review and meta-analysis of efficacy and toxicity of disease modifying anti-rheumatic drugs and biological agents for psoriatic arthritis.

  Annals of the rheumatic diseases 20080601

• Synthesis, potentiometric and antimicrobial studies on metal complexes of isoxazole Schiff bases.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080601

• Risk of ischaemic cardiovascular events from selective cyclooxygenase-2 inhibitors in osteoarthritis.

  Pharmacoepidemiology and drug safety 20080601

• Zonisamide decreases cortical excitability in patients with idiopathic generalized epilepsy.

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20080601

• Does drug-induced hypersensitivity syndrome elicit bullous pemphigoid?

  Allergology international : official journal of the Japanese Society of Allergology 20080601

• Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.

  Gastroenterology 20080601

• Identification of non-lipid LPA3 antagonists by virtual screening.

  Bioorganic & medicinal chemistry 20080601

• Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs.

  Journal of veterinary pharmacology and therapeutics 20080601

• Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.

  Bioorganic & medicinal chemistry 20080601

• Multimodal analgesia without parenteral narcotics for total knee arthroplasty.

  The Journal of arthroplasty 20080601

• Secondary osteoporosis in long-term bedridden patients with cerebral palsy.

  Pediatrics international : official journal of the Japan Pediatric Society 20080601

• Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity.

  Expert opinion on emerging drugs 20080601

• Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy.

  Journal of pharmacological sciences 20080601

• Hospitalization rates before and after initiation of paliperidone ER in patients with schizophrenia: results from open-label extensions of the US double-blind trials.

  Current medical research and opinion 20080601

• The active metabolite of leflunomide A771726 inhibits corneal neovascularization.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080601

• Conversion of oximes to carbonyl compounds by triscetylpyridinium tetrakis(oxodiperoxotungsto) phosphate (PCWP)-mediated oxidation with hydrogen peroxide.

  Molecules (Basel, Switzerland) 20080601

• Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks.

  The European journal of neuroscience 20080601

• Negative effect of parecoxib on bone mineral during fracture healing in rats.

  Acta orthopaedica 20080601

• Sitaxentan: new drug. Pulmonary hypertension: better to continue to use bosentan.

  Prescrire international 20080601

• 2,5-Dimethyl-3-(3-methyl-thio-phen-2-yl)perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione.

  Acta crystallographica. Section E, Structure reports online 20080601

• Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.

  The Journal of biological chemistry 20080530

• Effect of microdialysis perfusion of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol in the perifornical hypothalamus on sleep-wakefulness: role of delta-subunit containing extrasynaptic GABAA receptors.

  Neuroscience 20080515

• Theoretical study on the electronic states of formylcarbene (HC.CHO) and triplet ketene (H2CCO) and the ultraviolet absorption spectra attributable to these molecules.

  The journal of physical chemistry. A 20080508

• Efficacy of the selective extrasynaptic GABA A agonist, gaboxadol, in a model of transient insomnia: a randomized, controlled clinical trial.

  Sleep medicine 20080501

• Comparative study of the effect of luminal hypotonicity on mucosal permeability in rat upper gastrointestinal tract.

  Acta physiologica (Oxford, England) 20080501

• Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.

  Psychopharmacology 20080501

• Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release.

  American journal of physiology. Lung cellular and molecular physiology 20080501

• Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.

  Bioorganic & medicinal chemistry 20080501

• Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.

  Epilepsy research 20080501

• Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients.

  Clinical journal of the American Society of Nephrology : CJASN 20080501

• Paliperidone for treatment of schizophrenia.

  Schizophrenia bulletin 20080501

• Efficient and divergent synthesis of fully substituted 1H-pyrazoles and isoxazoles from cyclopropyl oximes.

  Organic letters 20080501

• Leflunomide therapy in kidney transplantation: ready for prime time?

  Clinical journal of the American Society of Nephrology : CJASN 20080501

• Pd-catalyzed carboetherification of beta,gamma-unsaturated oximes: a novel approach to Delta2-isoxazolines.

  Organic letters 20080501

• Leflunomide as a remission-maintaining therapy in difficult-to-treat dermatomyositis.

  Annals of the rheumatic diseases 20080501

• Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomy.

  Acta anaesthesiologica Scandinavica 20080501

• Clinical images: healing of sacroiliitis with leflunomide and sulfasalazine treatment.

  Arthritis and rheumatism 20080501

• [A 47-year-old dog breeder with chronic polyarthritis, weight loss and high fever].

  Zeitschrift fur Gastroenterologie 20080501

• Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled studies.

  The Journal of clinical psychiatry 20080501

• [Study on protective effects and its mechanism of leflunomide on renal tissue in rat IgA nephropathy model].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20080501

• Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells.

  Archives of pharmacal research 20080501

• Slow wave sleep enhancement with gaboxadol reduces daytime sleepiness during sleep restriction.

  Sleep 20080501

• Preserving confidentiality in the peer review process.

  JAMA 20080423

• Synthesis of 1-substituted benzo[c]isoxazol-3(1H)-imines via tandem nitroso-ene/intramolecular cyclizations of 2-nitrosobenzonitrile.

  The Journal of organic chemistry 20080418

• Paliperidone for schizophrenia.

  The Cochrane database of systematic reviews 20080416

• NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

  Cancer research 20080415

• 5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.

  Journal of medicinal chemistry 20080410

• Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.

  Journal of medicinal chemistry 20080410

• Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice.

  Behavioural brain research 20080409

• Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner.

  International journal of medical microbiology : IJMM 20080401

• Treatment of Crohn's disease with leflunomide as second-line immunosuppression : a phase 1 open-label trial on efficacy, tolerability and safety.

  Digestive diseases and sciences 20080401

• Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience.

  Brain & development 20080401

• Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors.

  Journal of neurochemistry 20080401

• Gender-dependent ATPA-induced changes in long-term potentiation in the rat lateral amygdala.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080401

• Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia.

  Psychopharmacology 20080401

• Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography.

  Human psychopharmacology 20080401

• Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20080401

• [Treatment of pulmonary arterial hypertension by endothelin receptor antagonists in 2008].

  La Revue de medecine interne 20080401

• Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium.

  Journal of endourology 20080401

• A new isoxazol from Glehnia littoralis.

  Fitoterapia 20080401

• On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.

  Neuropharmacology 20080401

• New advances in the treatment of schizophrenia. Introduction.

  Journal of clinical psychopharmacology 20080401

• Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials.

  Journal of clinical psychopharmacology 20080401

• Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia.

  Journal of clinical psychopharmacology 20080401

• Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia.

  Journal of clinical psychopharmacology 20080401

• Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies.

  Journal of clinical psychopharmacology 20080401

• Suppressive effect of leflunomide on rat hepatic stellate cell proliferation involves on PDGF-BB-elicited activation of three mitogen-activated protein kinases.

  Cytokine 20080401

• Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate.

  Journal of enzyme inhibition and medicinal chemistry 20080401

• Structure-function studies on the active site of the coelenterazine-dependent luciferase from Renilla.

  Protein science : a publication of the Protein Society 20080401

• A single-center experience with BK virus nephropathy.

  Clinical nephrology 20080401

• Leflunomide-induced subacute cutaneous lupus erythematosus with erythema multiforme-like lesions.

  Lupus 20080401

• Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety.

  Expert opinion on drug metabolism & toxicology 20080401

• New drug update: 2007.

  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20080401

• Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.

  Assay and drug development technologies 20080401

• A high-capacity membrane potential FRET-based assay for the sodium-coupled glucose co-transporter SGLT1.

  Assay and drug development technologies 20080401

• Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.

  Transplantation 20080327

• Burned rice straw reduces the availability of clomazone to barnyardgrass.

  The Science of the total environment 20080325

• Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes.

  FEBS letters 20080319

• 3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.

  Journal of medicinal chemistry 20080313

• Crunch time for peer review in lawsuit.

  Nature 20080306

• Translocation-positive acute myeloid leukemia associated with valproic acid therapy.

  Pediatric blood & cancer 20080301

• Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells.

  Cancer immunology, immunotherapy : CII 20080301

• Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system.

  Clinical pharmacology and therapeutics 20080301

• The immunomodulatory drug Leflunomide inhibits cell cycle progression of B-CLL cells.

  Leukemia 20080301

• Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts.

  Archives of oral biology 20080301

• Synthesis of novel steroidal D-ring substituted isoxazoline derivatives of 17-oxoandrostanes.

  Steroids 20080301

• Leflunomide as adjuvant treatment of dermatomyositis.

  Journal of the American Academy of Dermatology 20080301

• Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model.

  Cancer science 20080301

• Anti-inflammatory and analgesic activities of newly synthesized chiral peptide derivatives using (3-benzoyl- 4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester as starting material.

  Archiv der Pharmazie 20080301

• Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).

  Epilepsy research 20080301

• Paliperidone: An improvement over risperidone?

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080301

• Paliperidone for schizophrenia.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080301

• Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial.

  Pharmacogenomics 20080301

• Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity.

  Acta pharmaceutica (Zagreb, Croatia) 20080301

• Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study.

  Epileptic disorders : international epilepsy journal with videotape 20080301

• [Leflunomide-induced skin necrosis].

  Annales de dermatologie et de venereologie 20080301

• Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide.

  Pathology oncology research : POR 20080301

• Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells.

  Archives of pharmacal research 20080301

• Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.

  The AAPS journal 20080301

• Biotransformation of valdecoxib by plant cell cultures.

  Applied biochemistry and biotechnology 20080301

• The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.

  The Journal of physiology 20080215

• A synthetic derivative of plant allylpolyalkoxybenzenes induces selective loss of motile cilia in sea urchin embryos.

  ACS chemical biology 20080215

• Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

  Journal of medicinal chemistry 20080214

• Highly enantioselective synthesis of isoxazoline N-oxides.

  Chemical communications (Cambridge, England) 20080214

• Suppressive effects of leflunomide on leptin-induced TIMP-1 production involves on hepatic stellate cell proliferation and apoptosis.

  European journal of pharmacology 20080202

• Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake.

  Journal of molecular medicine (Berlin, Germany) 20080201

• Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20080201

• FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.

  Cardiovascular research 20080201

• Relationship between prolactin secretion, and plasma risperidone and 9-hydroxyrisperidone concentrations in adolescents with schizophreniform disorder.

  Psychoneuroendocrinology 20080201

• Preventive effects of perioperative parecoxib on post-discectomy pain.

  British journal of anaesthesia 20080201

• 1H, 13C and 15N NMR studies on adducts formation of rhodium(II) tetraacylates with some azoles in CDCl3 solution.

  Magnetic resonance in chemistry : MRC 20080201

• Pulmonary hypertension: basic concepts and practical management.

  The European respiratory journal 20080201

• Endothelin receptor antagonists in pulmonary arterial hypertension.

  The European respiratory journal 20080201

• Paliperidone-ER: first atypical antipsychotic with oral extended release formulation.

  Expert review of neurotherapeutics 20080201

• Sleep-stabilizing effects of E-6199, compared to zopiclone, zolpidem and THIP in mice.

  Sleep 20080201

• Toxic epidermal necrolysis due to zonisamide associated with reactivation of human herpesvirus 6.

  Archives of dermatology 20080201

• [Zonisamide in refractory essential tremor].

  Revista de neurologia 20080201

• Advances in diagnosis and treatment in patients with pulmonary arterial hypertension.

  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080201

• Paliperidone extended-release tablets for the acute and maintenance treatment of schizophrenia.

  Clinical therapeutics 20080201

• Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.

  Journal of thoracic imaging 20080201

• [Psoriatic arthritis].

  Annales de dermatologie et de venereologie 20080201

• (E)-2-Meth-oxy-6-[(5-methyl-isoxazol-3-yl)imino-meth-yl]phenol.

  Acta crystallographica. Section E, Structure reports online 20080201

• 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

  Journal of medicinal chemistry 20080124

• KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells.

  Biochemical pharmacology 20080115

• Antitumor effects of curcumin and structurally beta-diketone modified analogs on multidrug resistant cancer cells.

  Bioorganic & medicinal chemistry letters 20080115

• Effect of parecoxib on postoperative pain after lumbar spine surgery: a bicenter, randomized, double-blinded, placebo-controlled trial.

  Spine 20080115

• A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity.

  Bioorganic & medicinal chemistry letters 20080115

• Identification, isolation and characterization of potential degradation product in risperidone tablets.

  Journal of pharmaceutical and biomedical analysis 20080107

• Long-term use of zonisamide in refractory childhood-onset epilepsy.

  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20080101

• Is adjunctive open-label zonisamide effective for bipolar disorder?

  Journal of affective disorders 20080101

• Effects of zonisamide on experimental tremors in rats.

  Parkinsonism & related disorders 20080101

• Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.

  Annals of the rheumatic diseases 20080101

• Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?

  ChemMedChem 20080101

• Long-term cognitive and mood effects of zonisamide monotherapy in epilepsy patients.

  Epilepsy & behavior : E&B 20080101

• Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation.

  Neuroscience research 20080101

• Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone.

  Journal of clinical pharmacology 20080101

• Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market?

  Expert opinion on investigational drugs 20080101

• Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease.

  Modern rheumatology 20080101

• Safety and tolerability of oral paliperidone extended-release tablets in elderly patients with schizophrenia: a double-blind, placebo-controlled study with six-month open-label extension.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20080101

• Cardiovascular effects of valdecoxib: transducing human pharmacology results into clinical read-outs.

  Expert opinion on drug safety 20080101

• Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin.

  International journal of dermatology 20080101

• Use of cox-2 inhibitors in patients with retinal venous occlusive disease.

  Retina (Philadelphia, Pa.) 20080101

• Application of chiral cyclic nitrones to the diastereoselective synthesis of bicyclic isoxazolidine nucleoside analogues.

  Nucleosides, nucleotides & nucleic acids 20080101

• Emerging concepts in the medical and surgical treatment of obesity.

  Frontiers of hormone research 20080101

• Safety of parecoxib in patients with nonsteroidal anti-inflammatory drug-induced urticaria or angioedema.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080101

• Severe cutaneous adverse drug reaction to leflunomide: a report of two cases.

  Cutaneous and ocular toxicology 20080101

• Parecoxib as an alternative in COX-2 hypersensitivity.

  International journal of immunopathology and pharmacology 20080101

• Xerosis and pityriasis alba-like changes associated with zonisamide.

  Indian journal of dermatology, venereology and leprology 20080101

• Toluene-induced hearing loss in acivicin-treated rats.

  Neurotoxicology and teratology 20080101

• NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.

  Breast cancer research : BCR 20080101

• RM-11, an isoxazole derivative, accelerates restoration of the immune function in mice treated with cyclophosphamide.

  Pharmacological reports : PR 20080101

• Early analgesic effects of intravenous parecoxib and rectal diclofenac following laparoscopic sterilization: a double-blind, double-dummy randomized controlled trial.

  Journal of opioid management 20080101

• Synthesis of 5-(thiazol-5-yl)-4,5-dihydroisoxazoles from 3-chloropentane-2,4-dione.

  Journal of combinatorial chemistry 20080101

• Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101

• Parecoxib versus dipyrone (metamizole) for postoperative pain relief after hysterectomy : a prospective, single-centre, randomized, double-blind trial.

  Clinical drug investigation 20080101

• Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis.

  Modern rheumatology 20080101

• Solid-phase synthesis of heterocyclic nucleoside analogues: substituted uracils tethered to isoxazoles, isoxazolines, and triazoles from a selenopolystyrene resin.

  Journal of combinatorial chemistry 20080101

• Severe hypertriglygeridemia in a rheumatoid arthritis patient treated with leflunomide.

  Clinical and experimental rheumatology 20080101

• A new class of isoxazole derivatives: the M 1-9 series of compounds with immunotropic activity.

  Acta poloniae pharmaceutica 20080101

• Long-term therapeutic drug monitoring of risperidone and olanzapine identifies altered steady-state pharmacokinetics: a clinical, two-group, naturalistic study.

  Clinical drug investigation 20080101

• Solution phase synthesis of a diverse library of highly substituted isoxazoles.

  Journal of combinatorial chemistry 20080101

• [Leflunomide-induced toxic epidermal necrolysis].

  Therapie 20080101

• Endothelin receptor antagonism: role in the treatment of pulmonary arterial hypertension related to scleroderma.

  Drugs 20080101

• Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.

  Indian journal of experimental biology 20080101

• Formation of alpha-hydroxy-beta-diketones through hydroxylation of isoxazolium salts: stereoselective approach to angular cis-diols in polycyclic systems.

  Angewandte Chemie (International ed. in English) 20080101

• Multiple-day efficacy of parecoxib sodium treatment in postoperative bunionectomy pain.

  The Clinical journal of pain 20080101

• Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects.

  Texas Heart Institute journal 20080101

• [The efficacy and safety of the combination of leflunomide (Arava) and biological agents in treatment of rheumatoid arthritis].

  Reumatizam 20080101

• Combination treatment with infliximab and leflunomide in patients with active rheumatoid arthritis: safety and efficacy in an open-label clinical trial.

  Clinical and experimental rheumatology 20080101

• Relapsing polychondritis: reversible airway obstruction or asthma.

  Clinical and experimental rheumatology 20080101

• [Cardiovascular risk of cyclooxygenase selective inhibitors].

  Revista medica del Instituto Mexicano del Seguro Social 20080101

• FTIR studies on differential intermolecular association in crystalline and amorphous states of structurally related non-steroidal anti-inflammatory drugs.

  Molecular pharmaceutics 20080101

• [Rezonizat and cycloserine in complex therapy of drug resistant tuberculosis (comparative studies)].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101

• A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity.

  Current chemical genomics 20080101

• catena-Poly[bis-(sulfamethoxazolium) [[trichloridocadmate(II)]-μ-chlorido] monohydrate].

  Acta crystallographica. Section E, Structure reports online 20080101

• 5-Amino-3-(4-pyrid-yl)isoxazole.

  Acta crystallographica. Section E, Structure reports online 20080101

• Efficacy and safety of paliperidone extended-release tablets: results of a 6-week, randomized, placebo-controlled study.

  Biological psychiatry 20071215

• Dosage adjustments in hepatic dysfunction.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071215

• Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase.

  Journal of medicinal chemistry 20071213

• The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib.

  The Journal of organic chemistry 20071207

• The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model.

  Eye (London, England) 20071201

• Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis.

  Fungal genetics and biology : FG & B 20071201

• The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment.

  British journal of clinical pharmacology 20071201

• FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.

  Journal of lipid research 20071201

• The effects of TBC3214, a selective endothelin ETA receptor antagonist, on orthodontic tooth movement in rats.

  European journal of orthodontics 20071201

• Orthodontic tooth movement after different coxib therapies.

  European journal of orthodontics 20071201

• [Anticonvulsant treatment with zonisamide added to topiramate. A preliminary treatment analysis in 19 patients].

  Der Nervenarzt 20071201

• In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.

  Antimicrobial agents and chemotherapy 20071201

• Discovery of novel isoxazolines as anti-tuberculosis agents.

  Bioorganic & medicinal chemistry letters 20071201

• Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20071201

• A simple sample size formula for analysis of covariance in randomized clinical trials.

  Journal of clinical epidemiology 20071201

• LPA1 receptor activation promotes renal interstitial fibrosis.

  Journal of the American Society of Nephrology : JASN 20071201

• Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.

  Arteriosclerosis, thrombosis, and vascular biology 20071201

• The role of HLA-DRB1 shared epitope alleles in predicting short-term response to leflunomide in rheumatoid arthritis.

  Rheumatology (Oxford, England) 20071201

• The new antiepileptic drugs.

  Archives of disease in childhood. Education and practice edition 20071201

• Synthesis and bioassay of amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives.

  Chemical & pharmaceutical bulletin 20071201

• Paliperidone: new drug. Just a metabolite of risperidone, a neuroleptic soon off-patent.

  Prescrire international 20071201

• Emerging treatment of atopic dermatitis.

  Clinical reviews in allergy & immunology 20071201

• In vitro metabolism of leflunomide by mouse and human liver microsomes.

  Drug metabolism letters 20071201

• Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells.

  Biochemical and biophysical research communications 20071123

• The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.

  Biochemical and biophysical research communications 20071123

• Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells.

  Journal of immunology (Baltimore, Md. : 1950) 20071115

• Spectroscopic, and thermal studies of some new binuclear transition metal(II) complexes with hydrazone ligands containing acetoacetanilide and isoxazole.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101

• COX-2 inhibitors and postoperative ileus.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20071101

• Short-term treatment with gaboxadol improves sleep maintenance and enhances slow wave sleep in adult patients with primary insomnia.

  Psychopharmacology 20071101

• Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation.

  Transplant international : official journal of the European Society for Organ Transplantation 20071101

• GABAergic modulation of binge-like ethanol intake in C57BL/6J mice.

  Pharmacology, biochemistry, and behavior 20071101

• Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia.

  Journal of psychopharmacology (Oxford, England) 20071101

• Leflunomide-associated infections in rheumatoid arthritis.

  The Journal of rheumatology 20071101

• Selective and mixed endothelin receptor antagonism in cardiovascular disease.

  Trends in pharmacological sciences 20071101

• Successful treatment of cystoid macular edema with valdecoxib.

  Journal of cataract and refractive surgery 20071101

• The pharmacology and safety of paliperidone extended-release in the treatment of schizophrenia.

  Expert opinion on drug safety 20071101

• Protective effects of parecoxib, a cyclo-oxygenase-2 inhibitor, in postinfarction remodeling in the rat.

  Journal of cardiovascular pharmacology 20071101

• Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro.

  European journal of pharmacology 20071031

• Zonisamide in patients with essential tremor and Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20071031

• [Adverse effects of conventional DMARDs and biologic DMARDs].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• Processes affecting the dissipation of the herbicide isoxaflutole and its diketonitrile metabolite in agricultural soils under field conditions.

  Journal of agricultural and food chemistry 20071017

• Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition.

  Biochemical pharmacology 20071015

• Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

• Development and validation of a selective and sensitive bioanalytical procedure for the quantitative determination of gaboxadol in human plasma employing mixed mode solid phase extraction and hydrophilic interaction liquid chromatography with tandem mass spectroscopic detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

• Comparison of fate and transport of isoxaflutole to atrazine and metolachlor in 10 Iowa rivers.

  Environmental science & technology 20071015

• Aza-Prins-pinacol approach to 7-azabicyclo[2.2.1]heptanes: syntheses of (+/-)-epibatidine and (+/-)-epiboxidine.

  The Journal of organic chemistry 20071012

• Neurochemical regulation of sleep.

  Journal of psychiatric research 20071001

• Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score.

  Annals of the rheumatic diseases 20071001

• Rituximab for treatment-resistant extensive Wegener's granulomatosis--additive effects of a maintenance treatment with leflunomide.

  Clinical rheumatology 20071001

• Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection.

  American journal of respiratory cell and molecular biology 20071001

• Activatory properties of lysophosphatidic acid on human THP-1 cells.

  Inflammation 20071001

• A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy.

  American journal of respiratory cell and molecular biology 20071001

• Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage.

  Acta neurochirurgica 20071001

• Cutaneous infections with Stenotrophomonas maltophilia in patients using immunosuppressive medication.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20071001

• [Zonisamide and neuropathic pain].

  Revista de neurologia 20071001

• Neuroleptic malignant syndrome-like state in an epileptic patient with organic brain comorbidity treated with zonisamide and carbamazepine.

  Epilepsia 20071001

• Paliperidone: a new extended-release oral atypical antipsychotic.

  Expert opinion on pharmacotherapy 20071001

• Treatment, management, and monitoring of established rheumatoid arthritis.

  The Journal of family practice 20071001

• Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus.

  Chemistry & biology 20071001

• Michael acceptors as cysteine protease inhibitors.

  Mini reviews in medicinal chemistry 20071001

• Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam.

  Journal of chromatographic science 20071001

• [New ways in the management of rheumatoid arthritis in Hungary].

  Lege artis medicinae : uj magyar orvosi hirmondo 20071001

• Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.

  Brain research 20070919

• Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915

• Transferable potentials for phase equilibria. 9. Explicit hydrogen description of benzene and five-membered and six-membered heterocyclic aromatic compounds.

  The journal of physical chemistry. B 20070913

• Analytical and semipreparative enantioseparation of 9-hydroxyrisperidone, the main metabolite of risperidone, using high-performance liquid chromatography and capillary electrophoresis. Validation and determination of enantiomeric purity.

  Journal of chromatography. A 20070907

• The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs.

  Journal of molecular medicine (Berlin, Germany) 20070901

• Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons.

  Psychopharmacology 20070901

• Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.

  Molecular pharmacology 20070901

• Postnatal adrenalectomy impairs urinary concentrating ability by increased COX-2 and leads to renal medullary injury.

  American journal of physiology. Renal physiology 20070901

• Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.

  Bioorganic & medicinal chemistry letters 20070901

• Maternal exposure to leflunomide associated with blindness and cerebral palsy.

  Rheumatology (Oxford, England) 20070901

• Second look at leflunomide 'failure' to control cytomegalovirus infection in the setting of renal failure.

  Transplant infectious disease : an official journal of the Transplantation Society 20070901

• Hypersensitivity pneumonitis associated with leflunomide therapy.

  The Journal of rheumatology 20070901

• New antirheumatic drugs: any real added value? A critical overview of regulatory criteria for their marketing approval.

  European journal of clinical pharmacology 20070901

• Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis.

  Hepatology (Baltimore, Md.) 20070901

• The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis.

  International journal of molecular medicine 20070901

• A double-blind, placebo-controlled, randomized study evaluating the effect of paliperidone extended-release tablets on sleep architecture in patients with schizophrenia.

  International clinical psychopharmacology 20070901

• Improving the analgesic efficacy of intrathecal morphine with parecoxib after total abdominal hysterectomy.

  Anesthesia and analgesia 20070901

• In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1.

  American journal of veterinary research 20070901

• [Do DMARDs contibute to impaired healing after surgery? Should they be discontinued before surgery?].

  Deutsche medizinische Wochenschrift (1946) 20070901

• Leflunomide in psoriatic arthritis.

  Autoimmunity reviews 20070901

• Zonisamide for the treatment of Parkinson's disease.

  Expert review of neurotherapeutics 20070901

• Parecoxib sodium administered over several days reduces pain after gynecologic surgery via laparotomy.

  Journal of clinical anesthesia 20070901

• Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

  The Journal of biological chemistry 20070831

• Quantitative structure-activity relationship studies of [(biphenyloxy)propyl]isoxazole derivatives. Inhibitors of human rhinovirus 2 replication.

  Journal of medicinal chemistry 20070823

• Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.

  Journal of medicinal chemistry 20070823

• Synthesis of resorcinol derived spironitronates.

  Organic letters 20070816

• Validation and implementation of drug-dependent antibody assays in clinical trials for safety monitoring of patients dosed with roxifiban, an orally bioavailable glycoprotein IIb/IIIa antagonist.

  Journal of pharmaceutical and biomedical analysis 20070815

• [Neuromuscular disorders caused by adverse effects of antiepileptics].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20070810

• A case of Moebius syndrome presenting with congenital bilateral vocal cord paralysis.

  European journal of pediatrics 20070801

• Safety and efficacy of leflunomide in primary Sjögren's syndrome: a phase II pilot study.

  Annals of the rheumatic diseases 20070801

• Step-up combination versus switching of non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a retrospective observational study.

  Annals of the rheumatic diseases 20070801

• Cost analysis applied to postoperative analgesia regimens: a comparison between parecoxib and propacetamol.

  Pharmacy world & science : PWS 20070801

• Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.

  Journal of thrombosis and thrombolysis 20070801

• The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin.

  Experimental parasitology 20070801

• Eight versus 16-week re-evaluation period in rheumatoid arthritis patients treated with leflunomide or methotrexate accompanied by moderate dose prednisone.

  Rheumatology international 20070801

• Zonisamide and renal calculi in patients with epilepsy: how big an issue?

  Current medical research and opinion 20070801

• Tocolytic effect of parecoxib, a new parenteral cyclo-oxygenase-2-specific inhibitor, on the spontaneous and prostaglandin-induced contractions of rat isolated myometrium.

  Clinical and experimental pharmacology & physiology 20070801

• Enantioselective analysis of the antipsychotic 9-hydroxyrisperidone, main metabolite of risperidone, by chiral capillary EKC using dual CDs.

  Electrophoresis 20070801

• Withdrawal of COX-2 selective inhibitors rofecoxib and valdecoxib: impact on NSAID and gastroprotective drug prescribing and utilization.

  Current medical research and opinion 20070801

• Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons.

  Epilepsy research 20070801

• Early clinical experience with leflunomide in uveitis.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070801

• The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070801

• The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system.

  Journal of pharmacological sciences 20070801

• Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.

  The Journal of clinical psychiatry 20070801

• Effect of compound EXP-2528 on angiotensin II-induced E-selectin and VCAM-1 expression in rat brain microvascular endothelial cells in vitro.

  Yao xue xue bao = Acta pharmaceutica Sinica 20070801

• Na+-pyrophosphatase: a novel primary sodium pump.

  Biochemistry 20070731

• Restless legs syndrome induced by zonisamide.

  Movement disorders : official journal of the Movement Disorder Society 20070730

• Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.

  The Journal of physiology 20070715

• Influence of rainfall distribution on simulations of atrazine, metolachlor, and isoxaflutole/metabolite transport in subsurface drained fields.

  Journal of agricultural and food chemistry 20070711

• gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis.

  FEBS letters 20070710

• An efficient synthesis of nitroalkenes by alkene cross metathesis: facile access to small ring systems.

  Organic letters 20070705

• Asymmetric hydroformylation of vinyl acetate: application in the synthesis of optically active isoxazolines and imidazoles.

  Organic letters 20070705

• Ethanolamine and related amino alcohols increase basal and evoked release of [3H]-D-aspartic acid from synaptosomes by enhancing the filling of synaptic vesicles.

  European journal of pharmacology 20070702

• Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.

  Medicinal research reviews 20070701

• Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors.

  European journal of medicinal chemistry 20070701

• Lack of generalisation between the GABAA receptor agonist, gaboxadol, and allosteric modulators of the benzodiazepine binding site in the rat drug discrimination procedure.

  Psychopharmacology 20070701

• Leflunomide versus methotrexate in Wegener's granulomatosis.

  Rheumatology (Oxford, England) 20070701

• Risk of myocardial infarction associated with selective COX-2 inhibitors: meta-analysis of randomised controlled trials.

  Pharmacoepidemiology and drug safety 20070701

• Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study.

  Schizophrenia research 20070701

• Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.

  Bioorganic & medicinal chemistry letters 20070701

• Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.

  Bioorganic & medicinal chemistry letters 20070701

• Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis.

  Rheumatology (Oxford, England) 20070701

• Utility and sensitivity of the sore throat pain model: results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib.

  Journal of clinical pharmacology 20070701

• Leflunomide and methotrexate combination in refractory adult-onset Still's disease.

  The Annals of pharmacotherapy 20070701

• Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase.

  Nuclear medicine communications 20070701

• Molecularly imprinted polymers as antibody mimics in automated on-line fluorescent competitive assays.

  Analytical chemistry 20070701

• Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures.

  Epilepsy research 20070701

• Limitations in discerning the effects of risperidone and its 9-hydroxy metabolite on prolactin levels in a small study of patients with schizophrenia.

  Human psychopharmacology 20070701

• [Effective combination therapy of TNF antagonists with DMARDs].

  Nihon rinsho. Japanese journal of clinical medicine 20070701

• [Economic evaluation of a new treatment for rheumatoid arthritis].

  Nihon rinsho. Japanese journal of clinical medicine 20070701

• [Clinical study on effect of total panax notoginseng saponins on immune related inner environment imbalance in rheumatoid arthritis patients].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070701

• Polyamines in inflammation and their modulation by conventional anti-inflammatory drugs.

  Indian journal of experimental biology 20070701

• Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders.

  Clinical therapeutics 20070701

• Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients.

  Progress in neuro-psychopharmacology & biological psychiatry 20070630

• Development of potent inhibitors of the coxsackievirus 3C protease.

  Biochemical and biophysical research communications 20070622

• Bis- and trisuracil nucleosides with nucleobases anchored to 11-, 12-, and 16-membered macrocyclic scaffolds: synthesis and aggregation study.

  The Journal of organic chemistry 20070622

• Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.

  Bioorganic & medicinal chemistry 20070615

• The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.

  European journal of pharmacology 20070614

• Intra-articular injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transected knee in rats: role of excitatory amino acids.

  Osteoarthritis and cartilage 20070601

• Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

• Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium.

  American journal of physiology. Gastrointestinal and liver physiology 20070601

• Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.

  Bioorganic & medicinal chemistry 20070601

• Renal tubular acidosis associated with leflunomide.

  Rheumatology (Oxford, England) 20070601

• In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.

  Molecular endocrinology (Baltimore, Md.) 20070601

• HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery.

  ChemMedChem 20070601

• Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts.

  Prostaglandins & other lipid mediators 20070601

• Adjunctive zonisamide for treatment refractory anxiety.

  International journal of clinical practice 20070601

• Topical dosage form of valdecoxib: preparation and pharmacological evaluation.

  Acta pharmaceutica (Zagreb, Croatia) 20070601

• The influence of timing of administration on the analgesic efficacy of parecoxib in orthopedic surgery.

  Anesthesia and analgesia 20070601

• Therapy with immunosuppressive drugs and biological agents and use of contraception in patients with rheumatic disease.

  The Journal of rheumatology 20070601

• Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis.

  Expert opinion on pharmacotherapy 20070601

• Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms.

  Fundamental & clinical pharmacology 20070601

• Protein binding of flucloxacillin in neonates.

  Therapeutic drug monitoring 20070601

• Risk of interstitial lung disease associated with leflunomide treatment in Korean patients with rheumatoid arthritis.

  Arthritis and rheumatism 20070601

• Preliminary development of a responder index for chronic low back pain.

  The Journal of rheumatology 20070601

• Multimodal analgesia for radical prostatectomy provides better analgesia and shortens hospital stay.

  Journal of clinical anesthesia 20070601

• Cutaneous adverse reactions to valdecoxib distinct from Stevens-Johnson syndrome and toxic epidermal necrolysis.

  Archives of dermatology 20070601

• Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure.

  Journal of cardiovascular pharmacology 20070601

• Zonisamide: new drug. No advantage in refractory partial epilepsy.

  Prescrire international 20070601

• [Effects of leflunomide combined with hormone therapy for refractory IgA nephropathy].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601

• Heteroaryl-substituted phenols as potential antioxidants.

  The Journal of pharmacy and pharmacology 20070601

• Efficacy and tolerability of valdecoxib in treating the signs and symptoms of severe rheumatoid arthritis: a 12-week, multicenter, randomized, double-blind, placebo-controlled study.

  Clinical therapeutics 20070601

• [Development and identifiability analysis of parent-metabolite pharmacokinetic model for risperidone and its main active metabolite 9-hydroxyrisperidone].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070601

• [Leflunomide as a second choice treatment in patients with rheumatoid arthritis].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070601

• Molecule of the month. Paliperidone.

  Drug news & perspectives 20070601

• Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.

  Journal of medicinal chemistry 20070517

• Improved HPLC-MS/MS method for determination of isoxaflutole (balance) and its metabolites in soils and forage plants.

  Journal of agricultural and food chemistry 20070516

• The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo.

  European journal of pharmacology 20070507

• Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration.

  European journal of pharmacology 20070507

• Analgesic efficacy of single-dose parecoxib for corneal suturing in children.

  European journal of anaesthesiology 20070501

• COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.

  American journal of physiology. Renal physiology 20070501

• Preliminary evaluation in rheumatoid arthritis activity in patients treated with TNF-alpha blocker plus methotrexate versus methotrexate or leflunomide alone.

  Rheumatology international 20070501

• Effect of clomazone herbicide on biochemical and histological aspects of silver catfish (Rhamdia quelen) and recovery pattern.

  Chemosphere 20070501

• Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys.

  Drug metabolism and disposition: the biological fate of chemicals 20070501

• Sclerodermoid graft-versus-host disease-like lesions occurring after drug-induced hypersensitivity syndrome.

  The British journal of dermatology 20070501

• Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development.

  Neuropharmacology 20070501

• Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans.

  Anesthesiology 20070501

• Zonisamide decreases ethanol intake in rats and mice.

  Pharmacology, biochemistry, and behavior 20070501

• Novel oral agents for multiple sclerosis.

  Current neurology and neuroscience reports 20070501

• LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells.

  American journal of physiology. Cell physiology 20070501

• Paliperidone extended-release tablets: a new atypical antipsychotic.

  Journal of psychosocial nursing and mental health services 20070501

• A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels.

  Pharmacopsychiatry 20070501

• Lack of bioequivalence between generic risperidone oral solution and originator risperidone tablets.

  International journal of clinical pharmacology and therapeutics 20070501

• The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia.

  Sleep 20070501

• Current treatment of West syndrome in Japan.

  Journal of child neurology 20070501

• Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.

  Oncogene 20070419

• 4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.

  Journal of medicinal chemistry 20070419

• Surface chemistry of five-membered aromatic ring molecules containing two different heteroatoms on Si(111)-7 x 7.

  Journal of the American Chemical Society 20070418

• The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats.

  European journal of pharmacology 20070410

• KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

• Risperidone and paliperidone inhibit p-glycoprotein activity in vitro.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

• Platelet GPIIb/IIIa antagonist, XV459, in heparin-induced thrombocytopenia.

  American journal of hematology 20070401

• Durability of treatment with methotrexate in Venezuelan patients with rheumatoid arthritis.

  Rheumatology international 20070401

• Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder.

  Journal of pharmacokinetics and pharmacodynamics 20070401

• Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.

  The Journal of pharmacology and experimental therapeutics 20070401

• Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.

  Bioorganic & medicinal chemistry 20070401

• Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes.

  Bioorganic & medicinal chemistry 20070401

• Paliperidone: quo vadis?

  International journal of clinical practice 20070401

• Modulation of mucosal permeability by vasoactive intestinal peptide or lidocaine affects the adjustment of luminal hypotonicity in rat duodenum.

  Acta physiologica (Oxford, England) 20070401

• Successful treatment of cystoid macular edema with valdecoxib.

  Journal of cataract and refractive surgery 20070401

• Psychosis following initiation of zonisamide.

  The American journal of psychiatry 20070401

• [Inhibition of radiographic progression in rheumatoid arthritis by anti-rheumatic drugs (DMARDs)].

  Clinical calcium 20070401

• Zonisamide as treatment for seizures.

  The Nurse practitioner 20070401

• Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.

  Molecular cancer therapeutics 20070401

• Extended-release paliperidone: efficacy, safety and tolerability profile of a new atypical antipsychotic.

  Drugs of today (Barcelona, Spain : 1998) 20070401

• Potential efficacy of zonisamide in refractory juvenile myoclonic epilepsy: retrospective evidence from an Irish compassionate-use case series.

  Irish medical journal 20070401

• The effect of FK778 on the progression of chronic allograft nephropathy in a rat model.

  Transplantation 20070327

• From five- to six-membered rings: 3,4-diarylquinolinone as lead for novel p38MAP kinase inhibitors.

  Journal of medicinal chemistry 20070322

• The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.

  Bioorganic & medicinal chemistry letters 20070315

• Experiences with an identification and quantification program for inhibitor-positive milk samples.

  Analytica chimica acta 20070314

• Paliperidone (Invega) for schizophrenia.

  The Medical letter on drugs and therapeutics 20070312

• Reaction pathways of the diketonitrile degradate of isoxaflutole with hypochlorite in water.

  Journal of agricultural and food chemistry 20070307

• Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070301

• Autoantibodies, metalloproteinases and bone markers in rheumatoid arthritis patients are unable to predict their responses to infliximab.

  Rheumatology (Oxford, England) 20070301

• Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model.

  Fertility and sterility 20070301

• Cavitating pneumonia, a severe complication of leflunomide therapy in chronic polyarthritis.

  Rheumatology (Oxford, England) 20070301

• A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice.

  The Journal of pharmacology and experimental therapeutics 20070301

• AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists.

  Journal of thrombosis and haemostasis : JTH 20070301

• Gaboxadol, a selective extrasynaptic GABA(A) agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study.

  Neuropharmacology 20070301

• Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex.

  Journal of neurophysiology 20070301

• Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20070301

• Monitoring of the proton electrochemical gradient in reconstituted vesicles: quantitative measurements of both transmembrane potential and intravesicular pH by ratiometric fluorescent probes.

  Journal of fluorescence 20070301

• Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070301

• Parecoxib - getting to the heart of the matter.

  Anaesthesia 20070301

• Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation.

  Transplant infectious disease : an official journal of the Transplantation Society 20070301

• Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension.

  Pediatric research 20070301

• Pharmacokinetics and drug interactions with zonisamide.

  Epilepsia 20070301

• Suppressive effects of leflunomide on leptin-induced collagen I production involved in hepatic stellate cell proliferation.

  Experimental biology and medicine (Maywood, N.J.) 20070301

• Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension.

  Clinics in chest medicine 20070301

• Prospective study of zonisamide therapy for refractory idiopathic epilepsy in dogs.

  The Journal of small animal practice 20070301

• Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?

  Transplantation proceedings 20070301

• [Pulmonary hypertension treatment: future prospects].

  Archivos de bronconeumologia 20070301

• The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors.

  The European journal of neuroscience 20070301

• Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomnia.

  Sleep 20070301

• Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study.

  Clinical therapeutics 20070301

• Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study.

  Canadian family physician Medecin de famille canadien 20070301

• Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.

  Bioorganic & medicinal chemistry letters 20070215

• Sitaxsentan in the management of pulmonary arterial hypertension.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070215

• VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN.

  Journal of molecular biology 20070209

• Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial.

  European journal of anaesthesiology 20070201

• A single point mutation of the GABA(A) receptor alpha5-subunit confers fluoxetine sensitivity.

  Neuropharmacology 20070201

• Synthesis and biological evaluation of 4-methylideneisoxazolidin-5-ones--a new class of highly cytotoxic alpha-methylidene-gamma-lactones.

  European journal of medicinal chemistry 20070201

• Auto-modulation of neuroactive steroids on GABA A receptors: a novel pharmacological effect.

  Neuropharmacology 20070201

• Treatment of schizophrenia with paliperidone extended-release tablets: a 6-week placebo-controlled trial.

  Schizophrenia research 20070201

• Leflunomide-induced peripheral neuropathy.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070201

• Pulmonary adverse events with leflunomide--myth or reality?

  Rheumatology (Oxford, England) 20070201

• Paliperidone extended-release tablets for prevention of symptom recurrence in patients with schizophrenia: a randomized, double-blind, placebo-controlled study.

  Journal of clinical psychopharmacology 20070201

• Prolactin release in children treated with risperidone: impact and role of CYP2D6 metabolism.

  Journal of clinical psychopharmacology 20070201

• The effect of modulation of gamma-glutamyl transpeptidase and nitric oxide synthase activity on GSH homeostasis in HepG2 cells.

  Fundamental & clinical pharmacology 20070201

• Effect of leflunomide on the peripheral nerves in rheumatoid arthritis.

  Internal medicine journal 20070201

• Dual mycobacterial infection in the setting of leflunomide treatment for rheumatoid arthritis.

  Annals of the rheumatic diseases 20070201

• FDA approves new antipsychotic.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070201

• Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers.

  British journal of anaesthesia 20070201

• Function of phytochelatin synthase in catabolism of glutathione-conjugates.

  The Plant journal : for cell and molecular biology 20070201

• [Development of novel nuclear receptor ligands based on receptor-folding inhibition hypothesis].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201

• Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.

  Therapeutic drug monitoring 20070201

• [Newer antiepileptic drugs].

  No to shinkei = Brain and nerve 20070201

• Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury.

  Hepatology (Baltimore, Md.) 20070201

• Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient.

  Rheumatic diseases clinics of North America 20070201

• Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression.

  Surgical infections 20070201

• Rapidly disintegrating risperidone in subjects with schizophrenia or schizoaffective disorder: a summary of ten phase I clinical trials assessing taste, tablet disintegration time, bioequivalence, and tolerability.

  Clinical therapeutics 20070201

• A review of sitaxsentan sodium in patients with pulmonary arterial hypertension.

  Vascular health and risk management 20070201

• Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties.

  Journal of medicinal chemistry 20070125

• Cyclooxygenase inhibition and adverse remodeling during healing after myocardial infarction.

  Circulation 20070123

• The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115

• A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor.

  Movement disorders : official journal of the Movement Disorder Society 20070115

• Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study.

  Neurology 20070102

• The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate.

  Pharmacoepidemiology and drug safety 20070101

• Peripheral neuropathy associated with leflunomide: is there a risk patient profile?

  Pharmacoepidemiology and drug safety 20070101

• The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells.

  Blood 20070101

• Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?

  Cardiology 20070101

• Novel anticonvulsant drugs.

  Pharmacology & therapeutics 20070101

• Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation.

  Journal of leukocyte biology 20070101

• Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway.

  Neurochemistry international 20070101

• Leflunomide as an antiatherogenic drug.

  Medical hypotheses 20070101

• Zonisamide or levetiracetam for adults with cyclic vomiting syndrome: a case series.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070101

• Sitaxsentan: a selective endothelin-A receptor antagonist, for the treatment of pulmonary arterial hypertension.

  Expert opinion on pharmacotherapy 20070101

• Zonisamide for bipolar depression.

  Expert opinion on pharmacotherapy 20070101

• Sitaxsentan for treatment of pulmonary hypertension.

  The Annals of pharmacotherapy 20070101

• Prospective randomized, double-blind, placebo-controlled study of pre- and postoperative administration of a COX-2-specific inhibitor as opioid-sparing analgesia in major colorectal surgery.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20070101

• Cutaneous sarcoidosis therapy updated.

  Journal of the American Academy of Dermatology 20070101

• Clinical practice format for choosing a second-line disease modifying anti-rheumatic drug in early rheumatoid arthritis after failure of 6 months' first-line DMARD therapy.

  Joint, bone, spine : revue du rhumatisme 20070101

• Safety of parecoxib and valdecoxib after noncardiac surgery: lack of demonstration.

  Anesthesiology 20070101

• Reiter syndrome triggered by adalimumab (Humira) and leflunomide (Arava) in a patient with ankylosing spondylarthropathy and Crohn disease.

  The British journal of dermatology 20070101

• Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment.

  The Journal of bone and joint surgery. American volume 20070101

• Solid-phase synthesis of linked heterocycles from a selenopolystyrene resin.

  Journal of combinatorial chemistry 20070101

• Selective nucleophilic chemistry in the synthesis of 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acids.

  Journal of combinatorial chemistry 20070101

• [Valproate sodium and zonisamide associated interstitial pneumonitis in an infant].

  No to hattatsu = Brain and development 20070101

• Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070101

• FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070101

• Erratum to 'Safety of zonisamide therapy: prospective follow-up survey.'.

  Seizure 20070101

• COX-2 inhibitors celecoxib and parecoxib: valuable options for postoperative pain management.

  Current topics in medicinal chemistry 20070101

• Valdecoxib is as efficacious as diclofenac in the treatment of acute low back pain.

  The Clinical journal of pain 20070101

• Valproic acid improves psychotic agitation without influencing plasma risperidone levels in schizophrenic patients.

  Pharmacopsychiatry 20070101

• Study of the effects on DNA of two novel nucleoside derivatives synthesized as potential anti-HIV agents.

  Drug and chemical toxicology 20070101

• Sitaxentan: in pulmonary arterial hypertension.

  Drugs 20070101

• [Study on spectroscopy of 3-substituted phenyl-5-(3'-indolyl)-isoxazoline derivatives].

  Guang pu xue yu guang pu fen xi = Guang pu 20070101

• Effectiveness and safety of leflunomide in the clinical practice. A different experience.

  Clinical and experimental rheumatology 20070101

• [Anakinra, a recombinant human IL-1 receptor antagonist, in clinical practice. Outcome in 60 patients with severe rheumatoid arthritis].

  Reumatismo 20070101

• Paliperidone extended release.

  CNS drugs 20070101

• Rheumatoid arthritis patients with therapy-induced myelodysplastic syndrome present with long-term remission after recovery.

  Scandinavian journal of rheumatology 20070101

• Antiobesity carbonic anhydrase inhibitors.

  Current topics in medicinal chemistry 20070101

• New drugs: paliperidone, dasatinib, and decitabine.

  Journal of the American Pharmacists Association : JAPhA 20070101

• Pharmacology of epidermal growth factor inhibitors.

  The International journal of biological markers 20070101

• [Cost of rheumatoid arthritis in france: comparison leflunomide/etanercept].

  Therapie 20070101

• New drug for schizophrenia.

  FDA consumer 20070101

• Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice.

  Reproductive toxicology (Elmsford, N.Y.) 20070101

• COX-2 inhibitors and cardiovascular risk.

  Sub-cellular biochemistry 20070101

• Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats.

  Pharmacology 20070101

• [Severe vitamin K deficiency during a drug wash-out procedure with cholestyramine].

  Gastroenterologie clinique et biologique 20070101

• Acute hepatitis associated to leflunomide in a patient with rheumatoid arthritis.

  Gastroenterologia y hepatologia 20070101

• Prolonged survival with FK778 (malononitrilamide) monotherapy after small bowel transplantation: a large animal study.

  Transplantation proceedings 20070101

• Preparation and properties of valdecoxib-hydroxypropyl beta-cyclodextrin inclusion complex.

  PDA journal of pharmaceutical science and technology 20070101

• Clinical pharmacology and mechanism of action of zonisamide.

  Clinical neuropharmacology 20070101

• Staphylococcus aureus thymic abscesses associated with anti-tumour necrosis factor therapy.

  Scandinavian journal of rheumatology 20070101

• Conventional therapy of psoriatic arthritis: evidence-based review.

  Reumatismo 20070101

• Molecular and thermodynamic aspects of solubility advantage from solid dispersions.

  Molecular pharmaceutics 20070101

• An effective dose of valdecoxib in experimental mouse models of pain.

  Methods and findings in experimental and clinical pharmacology 20070101

• [Results of leflunomide treatment of psoriatic arthritis].

  Terapevticheskii arkhiv 20070101

• Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient.

  Modern rheumatology 20070101

• The therapy of Sjogren's syndrome: a review.

  La Clinica terapeutica 20070101

• Possible neuroleptic malignant syndrome associated with paliperidone.

  The Journal of neuropsychiatry and clinical neurosciences 20070101

• Forty years of antipsychotic Drug research--from haloperidol to paliperidone--with Dr. Paul Janssen.

  Arzneimittel-Forschung 20070101

• Zonisamide for essential tremor.

  Clinical neuropharmacology 20070101

• Leflunomide in psoriatic arthritis: a retrospective study of discontinuation rate in daily clinical practice compared with methotrexate.

  Clinical and experimental rheumatology 20070101

• Leflunomide and acute hypocalcemia.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20070101

• Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations.

  Pharmacological reports : PR 20070101

• [Pulmonary hypertension and right ventricular failure. Part XI. Endothelin receptor blockers in the treatment of primary pulmonary arterial hypertension].

  Kardiologiia 20070101

• [Leflunomide (Arava) in the treatment of rheumatoid arthritis].

  Reumatizam 20070101

• [Security of the combined treatment of methotrexate and leflunomide in patients with rheumatoid arthritis].

  Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) 20070101

• Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation.

  The Journal of biological chemistry 20061229

• Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells.

  Journal of immunology (Baltimore, Md. : 1950) 20061215

• Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles.

  Journal of medicinal chemistry 20061214

• [Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists].

  Deutsche medizinische Wochenschrift (1946) 20061208

• Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats.

  European journal of pharmacology 20061203

• Leflunomide combined with conventional disease-modifying antirheumatic drugs or biologics in patients with rheumatoid arthritis.

  Joint, bone, spine : revue du rhumatisme 20061201

• Update on the medical treatment of juvenile idiopathic arthritis.

  Current rheumatology reports 20061201

• Prolactin elevation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite.

  Human psychopharmacology 20061201

• Restoration of bile ducts in drug-induced vanishing bile duct syndrome due to zonisamide.

  The American journal of surgical pathology 20061201

• Comorbidity of eating disorders with bipolar disorder and treatment implications.

  Bipolar disorders 20061201

• Endothelin receptor antagonism in pulmonary arterial hypertension--a role for selective ET(A) inhibition?

  Current medical research and opinion 20061201

• The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression.

  Transplantation proceedings 20061201

• Prevalence and clinical course of BK virus nephropathy in pancreas after kidney transplant patients.

  Transplantation proceedings 20061201

• Indications for acceleration-dependent changes of membrane potential in the flagellate Euglena gracilis.

  Protoplasma 20061201

• Oxidation of sulfonamide antimicrobials by ferrate(VI) [Fe(VI)O4(2-)].

  Environmental science & technology 20061201

• Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial.

  The Journal of clinical psychiatry 20061201

• Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.

  Journal of medicinal chemistry 20061130

• Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes.

  Toxicology and applied pharmacology 20061115

• Reversal of regioselectivity and enhancement of rates of nitrile oxide cycloadditions through transient attachment of dipolarophiles to cyclodextrins.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20061115

• The effect of different antioxidants on glutathione turnover in human cell lines and their interaction with hydrogen peroxide.

  Chemico-biological interactions 20061107

• Increased disease activity is associated with a deteriorated lipid profile in patients with ankylosing spondylitis.

  Annals of the rheumatic diseases 20061101

• Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line.

  American journal of physiology. Cell physiology 20061101

• An analgesic model for assessment of acute pain response in osteoarthritis of the knee.

  Osteoarthritis and cartilage 20061101

• Influence of leflunomide on gastrointestinal Candida albicans infection induced in naive and arthritic newborn mice.

  International immunopharmacology 20061101

• Effects of nitric oxide synthase inhibition with or without cyclooxygenase-2 inhibition on resting haemodynamics and responses to exendin-4.

  British journal of pharmacology 20061101

• The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery.

  Anesthesia and analgesia 20061101

• Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.

  Anesthesiology 20061101

• [Spondylarthritides].

  Zeitschrift fur Rheumatologie 20061101

• Leflunomide-induced toxic epidermal necrolysis.

  International journal of dermatology 20061101

• Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide.

  International journal of urology : official journal of the Japanese Urological Association 20061101

• A long-term follow-up of zonisamide monotherapy.

  Epilepsia 20061101

• The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061101

• [New medications; zonisamide].

  Nederlands tijdschrift voor geneeskunde 20061021

• Decomposition and isomerization of 1,2-benzisoxazole: single-pulse shock-tube experiments, quantum chemical and transition-state theory calculations.

  The journal of physical chemistry. A 20061019

• Stabilization and determination of a PPAR agonist in human urine using automated 96-well liquid-liquid extraction and liquid chromatography/tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061002

• Leflunomide increases the risk of early healing complications in patients with rheumatoid arthritis undergoing elective orthopedic surgery.

  Rheumatology international 20061001

• [Analgesia in colon surgery. Can the use of NSAIDs reduce the opioid consumption following conventional and laparoscopic interventions?].

  Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20061001

• Zonisamide eradicated paroxysmal headache with EEG abnormalities triggered by hypertensive encephalopathy due to purpura nephritic syndrome.

  Brain & development 20061001

• Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents.

  Apoptosis : an international journal on programmed cell death 20061001

• Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors.

  The Journal of urology 20061001

• Zonisamide for migraine prophylaxis in refractory patients.

  Cephalalgia : an international journal of headache 20061001

• Angioinvasive aspergillosis presenting as neutropenic colitis.

  Histopathology 20061001

• Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac.

  Cancer science 20061001

• The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery.

  Anesthesia and analgesia 20061001

• Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients.

  Pharmacogenomics 20061001

• The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta.

  Transplantation proceedings 20061001

• Trying times for painkiller choices. Vioxx, Bextra, and Celebrex can increase the risk for heart attack and other cardiovascular problems. So can the old standbys, like ibuprofen and acetaminophen.

  Harvard heart letter : from Harvard Medical School 20061001

• Field dissipation and environmental hazard assessment of clomazone, molinate, and thiobencarb in Australian rice culture.

  Journal of agricultural and food chemistry 20060920

• Medical therapy: where are we now?

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060915

• KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties.

  Cancer research 20060915

• Effects of clomazone herbicide on hematological and some parameters of protein and carbohydrate metabolism of silver catfish Rhamdia quelen.

  Ecotoxicology and environmental safety 20060901

• Chronic pain and sensory changes after augmentation mammoplasty: long term effects of preincisional administration of methylprednisolone.

  Pain 20060901

• Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats.

  Neuropharmacology 20060901

• Substituent effects on 15N and 13C NMR chemical shifts of 3-phenylisoxazoles: a theoretical and spectroscopic study.

  Magnetic resonance in chemistry : MRC 20060901

• Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein.

  Psychopharmacology 20060901

• Parecoxib impairs early metaphyseal bone healing in rats.

  Archives of orthopaedic and trauma surgery 20060901

• Successful treatment with leflunomide of arthritis in systemic sclerosis patients.

  Rheumatology (Oxford, England) 20060901

• Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction.

  Kidney international 20060901

• Hepatic damage in biliary-obstructed rats is ameliorated by leflunomide treatment.

  Pediatric surgery international 20060901

• An evidence-based approach to the management of pulmonary arterial hypertension.

  Current opinion in cardiology 20060901

• Pulmonary alveolar proteinosis associated with a disease-modifying antirheumatoid arthritis drug.

  Respirology (Carlton, Vic.) 20060901

• Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension.

  European journal of clinical investigation 20060901

• Parecoxib--getting to the heart of the matter.

  Anaesthesia 20060901

• Lack of analgesic effect of parecoxib following laparoscopic cholecystectomy.

  Acta anaesthesiologica Scandinavica 20060901

• Valdecoxib for postoperative pain management after cesarean delivery: a randomized, double-blind, placebo-controlled study.

  Anesthesia and analgesia 20060901

• Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells.

  Journal of neurochemistry 20060901

• Formulation and evaluation of Nanostructured Lipid Carrier (NLC)-based gel of Valdecoxib.

  Drug development and industrial pharmacy 20060901

• Leflunomide for relapsing polychondritis: successful longterm treatment.

  The Journal of rheumatology 20060901

• Valdecoxib does not interfere with the CYP2D6 substrate metoprolol.

  International journal of clinical pharmacology and therapeutics 20060901

• Zonisamide for the treatment of epilepsy.

  Expert review of neurotherapeutics 20060901

• Enhancement of dissolution profile by solid dispersion (kneading) technique.

  AAPS PharmSciTech 20060901

• [What do we know about the cardiovascular toxicity of the NSAIDs?].

  Presse medicale (Paris, France : 1983) 20060901

• [Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?].

  Presse medicale (Paris, France : 1983) 20060901

• Biological targets for therapeutic interventions in COPD: clinical potential.

  International journal of chronic obstructive pulmonary disease 20060901

• Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents.

  Journal of medicinal chemistry 20060824

• Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.

  The Biochemical journal 20060815

• Antirheumatic drug use and the risk of acute myocardial infarction.

  Arthritis and rheumatism 20060815

• Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation.

  Journal of the American College of Cardiology 20060815

• COX-2 inhibitors and early failure of free vascular flaps.

  The New England journal of medicine 20060803

• Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity.

  European journal of pain (London, England) 20060801

• THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex.

  Cerebral cortex (New York, N.Y. : 1991) 20060801

• Reversible binding of celecoxib and valdecoxib with human serum albumin using fluorescence spectroscopic technique.

  Pharmacological research 20060801

• QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine.

  Neuropharmacology 20060801

• Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers.

  British journal of anaesthesia 20060801

• An open prospective study of zonisamide in acute bipolar depression.

  Journal of clinical psychopharmacology 20060801

• Zonisamide-induced mania in an essential tremor patient.

  Journal of clinical psychopharmacology 20060801

• Efficacy and safety of leflunomide alone and in combination with methotrexate in the treatment of refractory rheumatoid arthritis.

  Indian journal of medical sciences 20060801

• The COX-2 inhibitors--an update.

  American heart journal 20060801

• Preparation, characterization and in vitro dissolution studies of solid systems of valdecoxib with chitosan.

  Chemical & pharmaceutical bulletin 20060801

• Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis.

  Clinics (Sao Paulo, Brazil) 20060801

• [Paliperidone].

  Medizinische Monatsschrift fur Pharmazeuten 20060801

• Real-time and high throughput monitoring of cAMP in live cells using a fluorescent membrane potential-sensitive dye.

  Assay and drug development technologies 20060801

• How specific are 'target-specific' drugs? Celecoxib as a case in point.

  Molecular interventions 20060801

• Fluorinated acyclo-C-nucleoside analogues from glycals in two steps.

  Carbohydrate research 20060724

• Endothelin receptor antagonists for pulmonary arterial hypertension.

  The Cochrane database of systematic reviews 20060719

• delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol.

  European journal of pharmacology 20060717

• Pregnane X receptor is a target of farnesoid X receptor.

  The Journal of biological chemistry 20060714

• Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.

  Journal of medicinal chemistry 20060713

• Leflunomide/chloroquin combination therapy in rheumatoid arthritis: a pilot study.

  Clinical rheumatology 20060701

• Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells.

  Clinical immunology (Orlando, Fla.) 20060701

• Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells.

  Bone 20060701

• Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes.

  Bioorganic & medicinal chemistry 20060701

• Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined alpha2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities.

  Bioorganic & medicinal chemistry 20060701

• Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity.

  The Journal of investigative dermatology 20060701

• Copper complexes with heterocyclic sulfonamides: synthesis, spectroscopic characterization, microbiological and SOD-like activities: crystal structure of [Cu(sulfisoxazole)2(H2O)4] . 2H2O.

  Journal of inorganic biochemistry 20060701

• Remission of polyomavirus-induced graft nephropathy treated with low-dose leflunomide.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701

• Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity.

  Bioorganic & medicinal chemistry letters 20060701

• How is leflunomide prescribed and used in Australia? Analysis of prescribing and adverse effect reporting.

  Pharmacoepidemiology and drug safety 20060701

• Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis.

  Journal of the Society for Gynecologic Investigation 20060701

• Severe infections following leflunomide therapy for rheumatoid arthritis.

  Rheumatology (Oxford, England) 20060701

• An evidence-based approach to the management of pulmonary arterial hypertension.

  Current opinion in cardiology 20060701

• Serum concentrations of risperidone and 9-OH risperidone following intramuscular injection of long-acting risperidone compared with oral risperidone medication.

  Acta psychiatrica Scandinavica 20060701

• The efficacy of the non-opioid analgesics parecoxib, paracetamol and metamizol for postoperative pain relief after lumbar microdiscectomy.

  Anesthesia and analgesia 20060701

• Lysophosphatidic acid cooperates with 1alpha,25(OH)2D3 in stimulating human MG63 osteoblast maturation.

  Prostaglandins & other lipid mediators 20060701

• Subcellular localization and possible functions of gamma-glutamyltransferase in the radish (Raphanus sativus L.) plant.

  Bioscience, biotechnology, and biochemistry 20060701

• Forced-degradation study of valdecoxib as bulk drug and in tablet formulation by HPTLC.

  Journal of separation science 20060701

• [Cyclooxygenase inhibitors: a never ending story?].

  Giornale italiano di cardiologia (2006) 20060701

• Rofecoxib 50 mg and valdecoxib 20 or 40 mg in adults and adolescents with postoperative pain after third molar extraction: results of two randomized, double-blind, placebo-controlled, single-dose studies.

  Clinical therapeutics 20060701

• Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.

  The Journal of biological chemistry 20060630

• Determination of zonisamide by a coated monolithic column.

  Journal of chromatography. A 20060616

• Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20060616

• Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation.

  Bioorganic & medicinal chemistry 20060615

• Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20060615

• [Drug induced lung injuries in Japanese population].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20060610

• [Diagnosis of and therapy for diffuse lung diseases (discussion)].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20060610

• Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients.

  Annals of the rheumatic diseases 20060601

• The COX-2 specific inhibitor Valdecoxib versus tramadol in acute ankle sprain: a multicenter randomized, controlled trial.

  The American journal of sports medicine 20060601

• Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides.

  Bioorganic & medicinal chemistry 20060601

• Leflunomide and methotrexate combination therapy in daily clinical practice.

  Annals of the rheumatic diseases 20060601

• Leflunomide and warfarin interaction: case report and review of the literature.

  Pharmacotherapy 20060601

• Efficacy of a selective COX-2 inhibitor for controlling irregular uterine bleeding in DMPA users.

  Contraception 20060601

• Polyomavirus-associated nephropathy: update on antiviral strategies.

  Transplant infectious disease : an official journal of the Transplantation Society 20060601

• Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats.

  Pharmacology, biochemistry, and behavior 20060601

• Synthesis of the pyrazole isostere of valdecoxib.

  Die Pharmazie 20060601

• Pharmacokinetics and bioequivalence evaluation of risperidone in healthy male subjects with different CYP2D6 genotypes.

  Archives of pharmacal research 20060601

• Substrates induce conformational changes in human anion exchanger 1 (hAE1) as observed by fluorescence resonance energy transfer.

  Biochemistry 20060523

• Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan.

  Journal of the American College of Cardiology 20060516

• Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy.

  Clinical rheumatology 20060501

• Long-term efficacy and safety of monotherapy and adjunctive therapy with zonisamide.

  Epilepsy & behavior : E&B 20060501

• Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver.

  Pediatric surgery international 20060501

• Polymorphism on leflunomide: stability and crystal structures.

  Journal of pharmaceutical sciences 20060501

• Prostaglandin I2 release following mesenteric traction during abdominal surgery is mediated by cyclooxygenase-1.

  European journal of pharmacology 20060501

• Recent developments in the treatment of adult atopic dermatitis.

  The Australasian journal of dermatology 20060501

• Zonisamide prophylaxis in refractory pediatric headache.

  Headache 20060501

• Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritis.

  Arthritis and rheumatism 20060501

• Efficacy and safety of zonisamide monotherapy in a cohort of children with epilepsy.

  Pediatric neurology 20060501

• Safety of infliximab used in combination with leflunomide or azathioprine in daily clinical practice.

  The Journal of rheumatology 20060501

• Evidence of a new dechlorinated ochratoxin A derivative formed in opossum kidney cell cultures after pretreatment by modulators of glutathione pathways: correlation with DNA-adduct formation.

  Molecular nutrition & food research 20060501

• Parecoxib tolerability in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs.

  The Journal of allergy and clinical immunology 20060501

• Leflunomide: a possible alternative for gangciclovir sensitive and resistant cytomegalovirus infections.

  Postgraduate medical journal 20060501

• Formulation of solid dosage forms to overcome gastric pH interaction of the factor Xa inhibitor, BMS-561389.

  Pharmaceutical research 20060501

• Valdecoxib exposures reported to Texas poison centers during 2002-2004.

  Journal of toxicology and environmental health. Part A 20060501

• Anti-Jo-1 antibody positive polymyositis--successful therapy with leflunomide.

  Autoimmunity 20060501

• Prolonged psychosis after Amanita muscaria ingestion.

  Wiener klinische Wochenschrift 20060501

• [An animal model of antiepileptic-induced osteoporosis in rats].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060501

• The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.

  The Journal of biological chemistry 20060421

• Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.

  FEBS letters 20060417

• Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors.

  Bioorganic & medicinal chemistry letters 20060415

• Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs.

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20060415

• Practical asymmetric synthesis of a gamma-secretase inhibitor exploiting substrate-controlled intramolecular nitrile oxide-olefin cycloaddition.

  The Journal of organic chemistry 20060414

• 4-Alkoxycarbonyl- and aminocarbonyl-substituted isoxazoles as masked acrylates and acrylamides in the asymmetric synthesis of delta2-isoxazolines.

  The Journal of organic chemistry 20060414

• COX-2 inhibitors and pain after oral surgery - pertinent papers 2002-2003.

  The British journal of oral & maxillofacial surgery 20060401

• Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings.

  Bioorganic & medicinal chemistry 20060401

• Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid.

  Synapse (New York, N.Y.) 20060401

• Does preoperatively administered parecoxib prevent succinylcholine-associated myalgia? A randomized, placebo-controlled trial.

  European journal of anaesthesiology 20060401

• Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.

  Transplant international : official journal of the European Society for Organ Transplantation 20060401

• New targets in and potential treatments for cholesterol gallstone disease.

  Current opinion in investigational drugs (London, England : 2000) 20060401

• Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery.

  Acta physiologica (Oxford, England) 20060401

• [Skin ulceration after leflunomide treatment in two patients with rheumatoid arthritis].

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060401

• FK778: new cellular and molecular mechanisms of action.

  Transplantation proceedings 20060401

• Randomised controlled trial of leflunomide in the treatment of immunoglobulin A nephropathy.

  Nephrology (Carlton, Vic.) 20060401

• [Clinical observation on effects of leflunomid and total glucosides of paeony on rheumatoid arthritis].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060401

• [Drug-induced lichenoid eruptions].

  Annales de dermatologie et de venereologie 20060401

• Severe atopic dermatitis and leflunomide: first clinical experience and highlights of pertinent experimental data.

  Dermatology online journal 20060330

• A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses.

  Neurology 20060328

• Synthesis of enantiopure indolizinones by cascade ring enlargements of 4'-chlorospiro[cyclopropane-1,5'-isoxazolidines].

  The Journal of organic chemistry 20060317

• Diazocinones: synthesis and conformational analysis.

  The Journal of organic chemistry 20060317

• Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus.

  American journal of respiratory and critical care medicine 20060315

• Treatment of renal allograft polyoma BK virus infection with leflunomide.

  Transplantation 20060315

• Synthetic heteroprostanoids of A- and E-types as novel non-comprehensive inhibitors of adenylyl cyclase in rat hepatocytes.

  Biochemical and biophysical research communications 20060310

• Intestinal uptake and biodistribution of novel polymeric micelles after oral administration.

  Journal of controlled release : official journal of the Controlled Release Society 20060310

• The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.

  American journal of physiology. Gastrointestinal and liver physiology 20060301

• Pharmacological characterization of agonists at delta-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of gamma2.

  The Journal of pharmacology and experimental therapeutics 20060301

• In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone.

  Steroids 20060301

• The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections.

  British journal of pharmacology 20060301

• Emerging therapies in juvenile rheumatoid/idiopathic arthritis.

  Current problems in pediatric and adolescent health care 20060301

• Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy: an open label trial.

  Annals of the rheumatic diseases 20060301

• Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia.

  Acta pharmacologica Sinica 20060301

• Pneumonitis associated with leflunomide: a profile of New Zealand and Australian reports.

  Internal medicine journal 20060301

• Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery.

  Anesthesiology 20060301

• Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.

  Cancer research 20060301

• Combination of cyclosporine and leflunomide versus single therapy in severe rheumatoid arthritis.

  The Journal of rheumatology 20060301

• A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone.

  The American journal of psychiatry 20060301

• Evaluation of preemptive valdecoxib therapy on initial archwire placement discomfort in adults.

  The Angle orthodontist 20060301

• Determination of valdecoxib in serum using a HPLC-diode array detector and its application in a pharmacokinetic study.

  Die Pharmazie 20060301

• Treatment of multidrug-resistant cytomegalovirus retinitis with systemically administered leflunomide.

  Transplant infectious disease : an official journal of the Transplantation Society 20060301

• A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years.

  Clinical therapeutics 20060301

• Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex.

  Brain research 20060216

• Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases.

  Organic letters 20060216

• Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.

  Bioorganic & medicinal chemistry letters 20060215

• Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.

  Biochemical pharmacology 20060214

• Iterative, aqueous synthesis of beta3-oligopeptides without coupling reagents.

  Journal of the American Chemical Society 20060208

• Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones.

  FEBS letters 20060206

• Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.

  Journal of lipid research 20060201

• A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.

  Journal of lipid research 20060201

• Zonisamide as adjunctive therapy for refractory partial seizures.

  Epilepsy research 20060201

• Leflunomide-associated tuberculosis?

  Rheumatology (Oxford, England) 20060201

• Zonisamide in the management of epilepsy--Japanese experience.

  Epilepsy research 20060201

• Single dose parecoxib significantly improves ventilatory function in early extubation coronary artery bypass surgery: a prospective randomized double blind placebo controlled trial.

  British journal of anaesthesia 20060201

• Gaboxadol--a new awakening in sleep.

  Current opinion in pharmacology 20060201

• Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies.

  European journal of medicinal chemistry 20060201

• BK virus nephritis after renal transplantation.

  Kidney international 20060201

• Practical prescribing and long-term efficacy and safety of zonisamide.

  Epilepsy research 20060201

• Introduction to zonisamide.

  Epilepsy research 20060201

• Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting.

  Brain injury 20060201

• Methylprednisolone reduces pain, emesis, and fatigue after breast augmentation surgery: a single-dose, randomized, parallel-group study with methylprednisolone 125 mg, parecoxib 40 mg, and placebo.

  Anesthesia and analgesia 20060201

• Safety of cox-2 selective nonsteroidal antiinflammatory drugs for postsurgical pain.

  Anesthesia and analgesia 20060201

• Postsurgical safety of opioid-sparing cyclooxygenase-2 inhibitors.

  Anesthesiology 20060201

• Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy.

  Arthritis and rheumatism 20060201

• Ocular adverse effects associated with cyclooxygenase-2 inhibitors.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20060201

• Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat.

  Headache 20060201

• A comparison of valdecoxib and naproxen in the treatment of rheumatoid arthritis symptoms.

  Clinical therapeutics 20060201

• Substituted isoxazoles as potent inhibitors of p38 MAP kinase.

  ChemMedChem 20060201

• Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.

  Brain research bulletin 20060130

• Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.

  Journal of medicinal chemistry 20060126

• Determination of leflunomide in tablets by high performance liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20060123

• The effects of leflunomide on clinical parameters and serum levels of IL-6, IL-10, MMP-1 and MMP-3 in patients with resistant rheumatoid arthritis.

  Cytokine 20060121

• Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib.

  Bioorganic & medicinal chemistry letters 20060115

• Combination therapy using the cyclooxygenase-2 inhibitor Parecoxib and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin.

  Cancer immunology, immunotherapy : CII 20060101

• Simultaneous quantitation of etoricoxib, salicylic acid, valdecoxib, ketoprofen, nimesulide and celecoxib in plasma by high-performance liquid chromatography with UV detection.

  Biomedical chromatography : BMC 20060101

• Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.

  The Journal of surgical research 20060101

• FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.

  Journal of lipid research 20060101

• Advances in the therapy of Wegener's granulomatosis.

  Current opinion in rheumatology 20060101

• Zonisamide-induced suicidal ideation.

  Psychosomatics 20060101

• Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets.

  Chemical & pharmaceutical bulletin 20060101

• Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.

  BMC pharmacology 20060101

• Pharmacologic treatment of obesity.

  Advances in psychosomatic medicine 20060101

• Concurrent antiviral and immunosuppressive activities of leflunomide in vivo.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060101

• [Antimicrobial therapy in dermatology].

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060101

• A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.

  Neurochemistry international 20060101

• Coxibs and cardiovascular side-effects: from light to shadow.

  Current pharmaceutical design 20060101

• The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Leflunomide improves psoriasis in patients with psoriatic arthritis: an in-depth analysis of data from the TOPAS study.

  Dermatology (Basel, Switzerland) 20060101

• Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.

  BMC neuroscience 20060101

• Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV.

  Journal of analytical toxicology 20060101

• Disseminating drug prescribing information: the cox-2 inhibitors withdrawals.

  Journal of the American Medical Informatics Association : JAMIA 20060101

• Leflunomide in solid organ transplantation and polyoma virus infection.

  Advances in experimental medicine and biology 20060101

• Treatment of refractory CMV-infection following hematopoietic stem cell transplantation with the combination of foscarnet and leflunomide.

  Klinische Padiatrie 20060101

• Endogenous endophthalmitis by Propionibacterium acnes associated with leflunomide and adalimumab therapy.

  European journal of ophthalmology 20060101

• Can selective ligands for glutamate binding proteins be rationally designed?

  Current topics in medicinal chemistry 20060101

• Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis.

  Clinical and experimental rheumatology 20060101

• Suppression of circulating interleukin-6 concentrations is associated with decreased endothelial activation in rheumatoid arthritis.

  Clinical and experimental rheumatology 20060101

• Leflunomide in rheumatoid arthritis in daily practice: treatment discontinuation rates in comparison with other DMARDs.

  Clinical and experimental rheumatology 20060101

• Liquid chromatography/tandem mass spectrometry method for simultaneous determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma.

  Rapid communications in mass spectrometry : RCM 20060101

• Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis.

  Internal medicine (Tokyo, Japan) 20060101

• Host resistance to Candida albicans infection of mice with collagen-induced arthritis treated with leflunomide.

  Research in microbiology 20060101

• Pulmonary hypertension in older children: new approaches and therapies.

  Paediatric respiratory reviews 20060101

• Role of FK778 alone or in combination with tacrolimus or mTOR inhibitors as an immunomodulator of immunofunctions: in vitro evaluation of T cell proliferation and the expression of lymphocyte surface antigens.

  International journal of immunopathology and pharmacology 20060101

• Severe cutaneous adverse drug reaction to leflunomide: a report of five cases.

  Indian journal of dermatology, venereology and leprology 20060101

• [An antidestructive effect of leflunomide in early rheumatoid arthritis].

  Terapevticheskii arkhiv 20060101

• FK778 does not impair intestinal allograft absorption in a preclinical model of total small bowel transplantation.

  Transplantation proceedings 20060101

• FK778 and tacrolimus combination therapy to control acute rejection after pig intestinal transplantation.

  Transplantation proceedings 20060101

• Sorption of isoxaflutole diketonitrile degradate (DKN) and dicamba in unsaturated soil.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20060101

• Analgesic efficacy of valdecoxib for acute postoperative pain after bunionectomy.

  Journal of the American Podiatric Medical Association 20060101

• Responding rapidly to FDA drug withdrawals: design and application of a new approach for a consumer health website.

  Journal of medical Internet research 20060101

• Leflunomide-related acute interstitial pneumonia in two patients with rheumatoid arthritis: autopsy findings with a mosaic pattern of acute and organizing diffuse alveolar damage.

  Modern rheumatology 20060101

• Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?

  Clinical pharmacokinetics 20060101

• Leflunomide in clinical practice.

  Acta reumatologica portuguesa 20060101

• Valdecoxib provides effective pain relief following acute ankle sprain.

  The Journal of international medical research 20060101

• Interaction of non-steroidal anti-inflammatory drugs, etoricoxib and parecoxib sodium, with human serum albumin studied by fluorescence spectroscopy.

  Drug metabolism and drug interactions 20060101

• [Usage of the new parenteral selective cox-2 inhibitor dynastat in the gynecologic practice].

  Akusherstvo i ginekologiia 20060101

• Spectrophotometric stability-indicating methods for the determination of leflunomide in the presence of its degradates.

  Journal of AOAC International 20060101

• Influence of an adjuvant on the distribution of herbicides in a sediment/water system.

  Communications in agricultural and applied biological sciences 20060101

• Differential response of chickpea genotypes to isoxaflutole.

  Communications in agricultural and applied biological sciences 20060101

• [Rational therapeutic approach in rheumatoid arthritis].

  Annales Academiae Medicae Stetinensis 20060101

• An integrated approach to developing chemoenzymatic processes at the industrial scale.

  Ernst Schering Foundation symposium proceedings 20060101

• Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

  Journal of medicinal chemistry 20051229

• Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation.

  The Journal of biological chemistry 20051216

• Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).

  Bioorganic & medicinal chemistry letters 20051215

• Thyroid hormone stimulates gamma-glutamyl transpeptidase in the developing rat cerebra and in astroglial cultures.

  Journal of neuroscience research 20051215

• Double blind, randomised, placebo controlled study of leflunomide in the treatment of active ankylosing spondylitis.

  Annals of the rheumatic diseases 20051201

• Lethal pneumonitis under leflunomide therapy.

  Rheumatology (Oxford, England) 20051201

• An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.

  Journal of neurophysiology 20051201

• Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.

  Drug metabolism and disposition: the biological fate of chemicals 20051201

• Antiepileptic drugs and neuroprotection: current status and future roles.

  Epilepsy & behavior : E&B 20051201

• Dose-dependent interaction of paroxetine with risperidone in schizophrenic patients.

  Journal of clinical psychopharmacology 20051201

• Plasma risperidone levels and clinical response in patients with first-episode psychosis.

  Journal of clinical psychopharmacology 20051201

• Peripheral neuropathy in patients with systemic rheumatic diseases treated with leflunomide.

  Annals of the rheumatic diseases 20051201

• Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors.

  Epilepsy research 20051201

• Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures.

  Brain research. Brain research protocols 20051201

• Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: randomized controlled trials overestimate treatment response and effectiveness.

  Rheumatology (Oxford, England) 20051201

• Psoriatic arthritis.

  Joint, bone, spine : revue du rhumatisme 20051201

• Topical analgesia for chest tube removal in cardiac patients.

  Journal of cardiothoracic and vascular anesthesia 20051201

• What is new in the therapy of ANCA-associated vasculitides? Take home messages from the 12th workshop on ANCA and systemic vasculitides.

  Clinical nephrology 20051201

• A prospective evaluation of leflunomide therapy for cytomegalovirus disease in renal transplant recipients.

  Transplantation proceedings 20051201

• Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases.

  Nature clinical practice. Rheumatology 20051201

• Activatory properties of lysophosphatidic acid on human THP-1 cells.

  Inflammation 20051201

• More bad news about anti-inflammatory agents.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20051201

• Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines.

  Angewandte Chemie (International ed. in English) 20051125

• Increased risk of cardiovascular events with parecoxib/valdecoxib: a systematic review and meta-analysis.

  The New Zealand medical journal 20051125

• ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.

  The Journal of biological chemistry 20051104

• Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

  Journal of medicinal chemistry 20051103

• Characterization of fate and transport of isoxaflutole, a soil-applied corn herbicide, in surface water using a watershed model.

  Journal of agricultural and food chemistry 20051102

• Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography.

  Bioorganic & medicinal chemistry letters 20051101

• Safety and efficacy of leflunomide and infliximab versus methotrexate and infliximab combination therapy in rheumatoid arthritis.

  Rheumatology (Oxford, England) 20051101

• Subacute cutaneous lupus erythematosus precipitated by leflunomide.

  Clinical and experimental dermatology 20051101

• Synthesis and evaluation of trimethoxyphenyl isoxazolidines as inhibitors of secretory phospholipase A2 with anti-inflammatory activity.

  International journal of molecular medicine 20051101

• Effects of intrarenal administration of the cox-2 inhibitor parecoxib during porcine suprarenal aortic cross-clamping.

  Shock (Augusta, Ga.) 20051101

• [Leflunomide-related severe axonal neuropathy].

  Revue neurologique 20051101

• Sitaxsentan: a novel endothelin-A receptor antagonist for pulmonary arterial hypertension.

  Expert review of cardiovascular therapy 20051101

• COX-2 inhibitors and the heart: putting risk in perspective.

  Advance for nurse practitioners 20051101

• FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051101

• The design, synthesis and screening of a muscarinic acetylcholine receptor targeted compound library.

  Combinatorial chemistry & high throughput screening 20051101

• Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients.

  Clinical pharmacology and therapeutics 20051101

• Parecoxib versus tramadol for post-appendectomy pain.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20051101

• [Adverse events in rheumatoid arthritis patient with etanercept therapy: the appearance of osteomalacia].

  Recenti progressi in medicina 20051101

• Glutathione turnover in human cell lines in the presence of agents with glutathione influencing potential with and without acivicin inhibition of gamma-glutamyltranspeptidase.

  Biochimica et biophysica acta 20051030

• Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778.

  Transplantation 20051027

• Zonisamide add-on for drug-resistant partial epilepsy.

  The Cochrane database of systematic reviews 20051019

• An efficient synthesis of a dual PPAR alpha/gamma agonist and the formation of a sterically congested alpha-aryloxyisobutyric acid via a Bargellini reaction.

  The Journal of organic chemistry 20051014

• New approach to the practical synthesis of tri- or tetrasubstituted pyrimidine derivatives: a four-component coupling reaction from a functionalized silane, two types of aromatic nitriles, and acetals.

  Organic letters 20051013

• Heterocyclic ring scaffolds as small-molecule cholesterol absorption inhibitors.

  Organic & biomolecular chemistry 20051007

• [Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs)].

  Deutsche medizinische Wochenschrift (1946) 20051007

• Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.

  Journal of medicinal chemistry 20051006

• Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects.

  Neuropharmacology 20051001

• P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments.

  Human psychopharmacology 20051001

• Design of wide-spectrum inhibitors targeting coronavirus main proteases.

  PLoS biology 20051001

• Toxic neuropathy.

  Current opinion in neurology 20051001

• Spectroscopic and thermal properties of short wavelength metal (II) complexes containing alpha-isoxazolylazo-beta-diketones as co-ligands.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001

• Subtherapeutic risperidone serum concentrations in an adolescent during hemodialysis: a pharmacological puzzle.

  Therapeutic drug monitoring 20051001

• Valdecoxib for treatment of a single, acute, moderate to severe migraine headache.

  Headache 20051001

• Differential effects of vigabatrin and zonisamide on the neuropeptide Y system in the hippocampus of seizure prone gerbil.

  Neuropeptides 20051001

• Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies.

  Arthritis and rheumatism 20051001

• KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophrenia.

  Pharmacology, biochemistry, and behavior 20051001

• Clinical trials update from the European Society of Cardiology meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2, STRIDE-2, SOFA, IMAGINE, PREAMI, SIRIUS-II and ACTIVE.

  European journal of heart failure 20051001

• Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction.

  The Journal of organic chemistry 20050930

• One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.

  Organic letters 20050929

• On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis.

  The Journal of biological chemistry 20050916

• Integration of K+ and Cl- currents regulate steady-state and dynamic membrane potentials in cultured rat microglia.

  The Journal of physiology 20050915

• Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.

  Bioorganic & medicinal chemistry 20050915

• Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.

  Cytokine 20050907

• Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.

  Journal of neurophysiology 20050901

• Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.

  Bioorganic & medicinal chemistry 20050901

• VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium.

  Hepatology (Baltimore, Md.) 20050901

• Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells.

  Clinical and experimental immunology 20050901

• How celecoxib could be safer, how valdecoxib might have been.

  The Annals of pharmacotherapy 20050901

• The antinociceptive effect of local or systemic parecoxib combined with lidocaine/clonidine intravenous regional analgesia for complex regional pain syndrome type I in the arm.

  Anesthesia and analgesia 20050901

• Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis.

  British journal of clinical pharmacology 20050901

• Leflunomide in the treatment of rheumatoid arthritis. An analysis of predictors for treatment continuation.

  British journal of clinical pharmacology 20050901

• Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition.

  Biological & pharmaceutical bulletin 20050901

• Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation.

  Arthritis and rheumatism 20050901

• Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide.

  Acta crystallographica. Section C, Crystal structure communications 20050901

• [Disease modifying antirheumatic drugs with inhibitory effect on osteoclastogenesis].

  Nihon rinsho. Japanese journal of clinical medicine 20050901

• Nonsteroidal anti-inflammatory drugs: confusion, controversy and dental implications.

  Journal (Canadian Dental Association) 20050901

• [Treatment of proliferative lupus nephritis with leflunomide and steroid: a prospective multi-center controlled clinical trial].

  Zhonghua nei ke za zhi 20050901

• Subacute cutaneous lupus erythematosus associated with leflunomide.

  Cutis 20050901

• In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats.

  Neurochemical research 20050901

• Zonisamide: review of its use in epilepsy therapy.

  Drugs of today (Barcelona, Spain : 1998) 20050901

• Development of a novel and automated fluorescent immunoassay for the analysis of beta-lactam antibiotics.

  Journal of agricultural and food chemistry 20050824

• Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking.

  Journal of medicinal chemistry 20050811

• Risperidone plasma levels, clinical response and side-effects.

  European archives of psychiatry and clinical neuroscience 20050801

• Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes.

  American journal of physiology. Gastrointestinal and liver physiology 20050801

• Ischemic tolerance induction in organotypic hippocampal slices: role for the GABA(A) receptor?

  Neuroscience letters 20050801

• Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient.

  Clinics in geriatric medicine 20050801

• Discovery of substituted isoxazolecarbaldehydes as potent spermicides, acrosin inhibitors and mild anti-fungal agents.

  Human reproduction (Oxford, England) 20050801

• Inflammatory bone destruction and osteoimmunology.

  Journal of periodontal research 20050801

• Distinct patterns of expression and regulation of GABA receptors containing the delta subunit in cerebellar granule and hippocampal neurons.

  Journal of neurochemistry 20050801

• Use of combination of leflunomide with biological agents in treatment of rheumatoid arthritis.

  The Journal of rheumatology 20050801

• Leflunomide: new indication. In psoriatic rheumatism: too many risks, too little efficacy.

  Prescrire international 20050801

• Endothelin antagonism in pulmonary arterial hypertension.

  Seminars in respiratory and critical care medicine 20050801

• Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.

  Naunyn-Schmiedeberg's archives of pharmacology 20050801

• Population pharmacokinetics of the active metabolite of leflunomide in pediatric subjects with polyarticular course juvenile rheumatoid arthritis.

  Journal of pharmacokinetics and pharmacodynamics 20050801

• Lithium differs from anticonvulsant mood stabilizers in prefrontal cortical and accumbal dopamine release: role of 5-HT(1A) receptor agonism.

  Brain research 20050712

• Further action taken on COX 2 inhibitors in Europe.

  BMJ (Clinical research ed.) 20050702

• Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.

  Journal of neural transmission (Vienna, Austria : 1996) 20050701

• FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets.

  American journal of physiology. Cell physiology 20050701

• Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes.

  Endocrinology 20050701

• Use of zonisamide in pediatric patients.

  Pediatric neurology 20050701

• Synthesis of some new steroidal [16alpha,17alpha-d]-isoxazolines.

  Steroids 20050701

• Effects of the herbicides clomazone, quinclorac, and metsulfuron methyl on acetylcholinesterase activity in the silver catfish (Rhamdia quelen) (Heptapteridae).

  Ecotoxicology and environmental safety 20050701

• Paternal and maternal exposure to leflunomide: pregnancy and neonatal outcome.

  Annals of the rheumatic diseases 20050701

• Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses.

  Nature genetics 20050701

• Influence of age and gender on risperidone plasma concentrations.

  Journal of psychopharmacology (Oxford, England) 20050701

• 2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis.

  Journal of vascular and interventional radiology : JVIR 20050701

• Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition.

  Clinical pharmacology and therapeutics 20050701

• Leflunomide and peripheral neuropathy: a potential interaction between uracil/tegafur and leflunomide.

  Clinical pharmacology and therapeutics 20050701

• Pulmonary embolism in a woman taking oral contraceptives and valdecoxib.

  PLoS medicine 20050701

• Cyclooxygenase-2 inhibitors: a new therapeutic option in the treatment of macular edema after cataract surgery.

  Journal of cataract and refractive surgery 20050701

• An evaluation of preemptive valdecoxib therapy on discomfort caused by initial archwire placement in adult orthodontic patients.

  Texas dental journal 20050701

• Efficacy of levetiracetam at 12 months in children classified by seizure type, cognitive status, and previous anticonvulsant drug use.

  Journal of child neurology 20050701

• Broad-spectrum efficacy of zonisamide at 12 months in children with intractable epilepsy.

  Journal of child neurology 20050701

• Effect of selective cyclooxygenase-2 inhibitors on heart rate in healthy young men.

  The American journal of cardiology 20050615

• [Effective and 15 years experience. New add-on option in epilepsy therapy]].

  MMW Fortschritte der Medizin 20050609

• [Control of side effects. Add on therapy demonstrates good tolerance].

  MMW Fortschritte der Medizin 20050609

• Biaryl isoxazolinone antibacterial agents.

  Bioorganic & medicinal chemistry letters 20050602

• Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids.

  Biomedical chromatography : BMC 20050601

• Comparative actions of clomazone on beta-carotene levels and growth in rice (Oryza sativa) and watergrasses (Echinochloa spp).

  Pest management science 20050601

• Leflunomide-induced subacute cutaneous lupus erythematosus.

  Rheumatology (Oxford, England) 20050601

• Laryngeal involvement in rheumatoid arthritis.

  Rheumatology international 20050601

• Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis.

  International immunopharmacology 20050601

• Zonisamide for West syndrome: a comparison of clinical responses among different titration rate.

  Brain & development 20050601

• The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor.

  European journal of clinical pharmacology 20050601

• Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide.

  Journal of immunology (Baltimore, Md. : 1950) 20050601

• Novel therapies for ankylosing spondylitis.

  Current rheumatology reports 20050601

• Rescuing COX-2 inhibitors from the waste bin.

  Journal of the National Cancer Institute 20050601

• Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.

  European journal of pharmacology 20050601

• Valdecoxib withdrawal leaves pain relief treatment gap.

  Gastroenterology 20050601

• Leflunomide induced acute interstitial pneumonia.

  The Journal of rheumatology 20050601

• The meaning of pain relief in a clinical trial.

  The journal of pain : official journal of the American Pain Society 20050601

• Toward the definition of immunosuppressive regimens with antitumor activity.

  Transplantation proceedings 20050601

• Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey's analysis.

  Journal of natural products 20050601

• Cox-2 inhibitors: still no decisive action.

  Prescrire international 20050601

• Anticonvulsant drug therapies.

  Journal of psychosocial nursing and mental health services 20050601

• [Development of dermatomyositis in a woman with rheumatoid arthritis treated with leflunomide].

  Anales de medicina interna (Madrid, Spain : 1984) 20050601

• Fully automated liquid-liquid extraction for the determination of a novel insulin sensitizer in human plasma by heated nebulizer and turbo ionspray liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525

• Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity.

  Bioorganic & medicinal chemistry 20050516

• FDA ponders future of NSAIDs: Pfizer reluctantly withdraws Bextra.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050515

• New restrictions on celecoxib (Celebrex) use and the withdrawal of valdecoxib (Bextra).

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050510

• Theoretical study on the excited states of HCN.

  The Journal of chemical physics 20050508

• Effects of gabaergic drugs on reserpine-induced oral dyskinesia.

  Behavioural brain research 20050507

• Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050504

• Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.

  Bioorganic & medicinal chemistry letters 20050502

• Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.

  Bioorganic & medicinal chemistry letters 20050502

• The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.

  Bioorganic & medicinal chemistry letters 20050502

• Valdecoxib-associated acute generalized exanthematous pustulosis.

  Burns : journal of the International Society for Burn Injuries 20050501

• Vioxx, Celebrex, Bextra....do we have a new target for anti-inflammatory and antipyretic therapy?

  American journal of physiology. Regulatory, integrative and comparative physiology 20050501

• Valdecoxib is associated with improved dyspepsia-related health compared with nonspecific NSAIDs in patients with osteoarthritis or rheumatoid arthritis.

  The American journal of gastroenterology 20050501

• Changing role of COX-2 inhibitors in the perioperative period: is parecoxib really the answer?

  Anesthesia and analgesia 20050501

• A randomized, double-blind comparison between parecoxib sodium and propacetamol for parenteral postoperative analgesia after inguinal hernia repair in adult patients.

  Anesthesia and analgesia 20050501

• Cyclodextrin complexes of valdecoxib: properties and anti-inflammatory activity in rat.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050501

• Predominant role of the 9-hydroxy metabolite of risperidone in elevating blood prolactin levels.

  The American journal of psychiatry 20050501

• COX-2-selective inhibitor valdecoxib induces severe allergic skin reactions.

  The Journal of allergy and clinical immunology 20050501

• Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial.

  The Journal of clinical psychiatry 20050501

• Effect of glutamine analogue-acivicin on tumor induced angiogenesis in Ehrlich ascites carcinoma.

  Indian journal of experimental biology 20050501

• [Cardiovascular risks of Cox-2-antagonists. Opinion on the marketed name rofecoxib, and its market-withdrawn valdecoxib and the actual therapeutic restrictions].

  Zeitschrift fur Rheumatologie 20050501

• FK-778 Astellas.

  Current opinion in investigational drugs (London, England : 2000) 20050501

• The novel immunosuppressant FK778 inhibits formation of the immunologic Synapse.

  Transplantation proceedings 20050501

• Pfizer withdraws Bextra in South Africa.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20050501

• Leflunomide: long-term clinical experience and new uses.

  Expert opinion on pharmacotherapy 20050501

• [An exploratory study on in vitro effects and mechanism of leflunomide on dendritic cells of systemic lupus erythematosus].

  Zhonghua nei ke za zhi 20050501

• A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427

• Leflunomide or methotrexate for juvenile rheumatoid arthritis.

  The New England journal of medicine 20050421

• Succinct synthesis of beta-amino acids via chiral isoxazolines.

  Journal of the American Chemical Society 20050420

• Researchers plan to continue to study COX-2 inhibitors in cancer treatment and prevention.

  Journal of the National Cancer Institute 20050420

• Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420

• Another popular painkiller gets the government's hook.

  U.S. news & world report 20050418

• Pfizer is asked to suspend sales of painkiller.

  BMJ (Clinical research ed.) 20050416

• Tandem mass spectrometric assay of succinylacetone in urine for the diagnosis of hepatorenal tyrosinemia.

  Analytical biochemistry 20050415

• Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase.

  Biochemistry 20050412

• Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.

  Journal of medicinal chemistry 20050407

• Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis.

  Annals of the rheumatic diseases 20050401

• The influence of previous and concomitant leflunomide on the efficacy and safety of infliximab therapy in patients with rheumatoid arthritis; a longitudinal observational study.

  Rheumatology (Oxford, England) 20050401

• Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050401

• Evidence for a second binding/transport site for chloride in erythrocyte anion transporter AE1 modified at glutamate 681.

  Biophysical journal 20050401

• Leflunomide and azathioprine combination in refractory adult-onset Still's disease.

  The Annals of pharmacotherapy 20050401

• Novel [(biphenyloxy)propyl]isoxazole derivatives for inhibition of human rhinovirus 2 and coxsackievirus B3 replication.

  The Journal of antimicrobial chemotherapy 20050401

• Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys.

  Psychopharmacology 20050401

• Neuropathy associated with leflunomide: a case series.

  Annals of the rheumatic diseases 20050401

• Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.

  Bioorganic & medicinal chemistry letters 20050401

• Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine.

  Bioorganic & medicinal chemistry letters 20050401

• Exacerbation of carpal tunnel syndrome under treatment with valdecoxib.

  Anesthesia and analgesia 20050401

• Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP.

  The FEBS journal 20050401

• Using thrombelastography to determine the efficacy of the platelet glycoprotein IIb/IIIa antagonist, roxifiban, on platelet/fibrin-mediated clot dynamics in humans.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20050401

• Lack of clinically significant pharmacokinetic interactions between zonisamide and lamotrigine at steady state in patients with epilepsy.

  Therapeutic drug monitoring 20050401

• Physical function and health related quality of life: analysis of 2-year data from randomized, controlled studies of leflunomide, sulfasalazine, or methotrexate in patients with active rheumatoid arthritis.

  The Journal of rheumatology 20050401

• Continuous indices of core data set measures in rheumatoid arthritis clinical trials: lower responses to placebo than seen with categorical responses with the American College of Rheumatology 20% criteria.

  Arthritis and rheumatism 20050401

• Locomotor activity detects subunit-selective effects of agonists and decahydroisoquinoline antagonists at AMPA/kainic acid ionotropic glutamate receptors in adult rats.

  Psychopharmacology 20050401

• Staphylococcus aureus bacteremia, Australia.

  Emerging infectious diseases 20050401

• Synthesis and characterization of novel 6-fluoro-4-piperidinyl-1,2-benzisoxazole amides and 6-fluoro-chroman-2-carboxamides: antimicrobial studies.

  Bioorganic & medicinal chemistry 20050401

• Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2.

  Chemistry & biology 20050401

• Parecoxib: renal failure.

  Prescrire international 20050401

• Valdecoxib: cutaneous and vascular risks.

  Prescrire international 20050401

• [New therapeutic perspectives in Sjögren syndrome: leflunomide].

  Recenti progressi in medicina 20050401

• Raising the safety bar--the FDA's coxib meeting.

  The New England journal of medicine 20050331

• Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.

  Journal of medicinal chemistry 20050324

• Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.

  Journal of medicinal chemistry 20050324

• Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.

  The New England journal of medicine 20050317

• COX-2 inhibitors--lessons in drug safety.

  The New England journal of medicine 20050317

• COX-2 inhibitors--a lesson in unexpected problems.

  The New England journal of medicine 20050317

• Leflunomide for polyomavirus type BK nephropathy.

  The New England journal of medicine 20050317

• Pulmonary abscess due to leflunomide use in rheumatoid arthritis: a case report.

  Rheumatology international 20050301

• A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma.

  Biomedical chromatography : BMC 20050301

• Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.

  The Journal of pharmacology and experimental therapeutics 20050301

• Regulation of carbohydrate metabolism by the farnesoid X receptor.

  Endocrinology 20050301

• Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling.

  Journal of lipid research 20050301

• Leflunomide in rheumatoid arthritis: recommendations through a process of consensus.

  Rheumatology (Oxford, England) 20050301

• Guideline for anti-TNF-alpha therapy in psoriatic arthritis.

  Rheumatology (Oxford, England) 20050301

• Pharmacokinetics and D2 receptor occupancy of long-acting injectable risperidone (Risperdal Consta) in patients with schizophrenia.

  The international journal of neuropsychopharmacology 20050301

• Risperidone and breast-feeding.

  Journal of psychopharmacology (Oxford, England) 20050301

• Prediction of response to risperidone treatment with respect to plasma concencentrations of risperidone, catecholamine metabolites, and polymorphism of cytochrome P450 2D6.

  International clinical psychopharmacology 20050301

• Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol.

  Parkinsonism & related disorders 20050301

• [New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050301

• Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis.

  Alimentary pharmacology & therapeutics 20050301

• Successful treatment of a leg ulcer occurring in a rheumatoid arthritis patient under leflunomide therapy.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20050301

• COX-2 inhibitor induced anuric renal failure in a previously healthy young woman.

  Clinical nephrology 20050301

• [Treatment with leflunomide in rheumatoid arthritis].

  Zeitschrift fur Rheumatologie 20050301

• Parecoxib versus ibuprofen.

  Journal of the American Dental Association (1939) 20050301

• Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center.

  Journal of child neurology 20050301

• Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal.

  Molecular and cellular biochemistry 20050301

• Lessons to learn from the COX-2 saga. Yes, FDA reforms are needed. And marketing distorts how medications are used. But one moral to the story is that all drugs have risks.

  Harvard health letter 20050301

• Coxibs: can this class of drugs survive?

  Vascular health and risk management 20050301

• Drug safety. FDA panel urges caution on many anti-inflammatory drugs.

  Science (New York, N.Y.) 20050225

• Vioxx may go back on sale after scraping past FDA panel.

  Nature 20050224

• Continued use of zonisamide following development of renal calculi.

  Neurology 20050222

• Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro.

  Bioorganic & medicinal chemistry letters 20050215

• Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.

  Bioorganic & medicinal chemistry letters 20050215

• Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.

  Journal of medicinal chemistry 20050210

• Positional ordering of reacting groups contributes significantly to the efficiency of proton transfer at an antibody active site.

  Journal of the American Chemical Society 20050202

• Debilitating diarrhoea and weight loss due to colitis in two RA patients treated with leflunomide.

  Clinical rheumatology 20050201

• Role of glutathione in reduction of arsenate and of gamma-glutamyltranspeptidase in disposition of arsenite in rats.

  Toxicology 20050201

• Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury.

  Cardiovascular research 20050201

• Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.

  Bioorganic & medicinal chemistry 20050201

• Zonisamide monotherapy for epilepsy in children and young adults.

  Pediatric neurology 20050201

• Serum concentrations of risperidone and 9-hydroxyrisperidone after administration of the long-acting injectable form of risperidone: evidence from a routine therapeutic drug monitoring service.

  Therapeutic drug monitoring 20050201

• Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

  Antimicrobial agents and chemotherapy 20050201

• The cyclooxygenase-2-specific inhibitor parecoxib sodium is as effective as 12 mg of morphine administered intramuscularly for treating pain after gynecologic laparotomy surgery.

  Anesthesia and analgesia 20050201

• Post-coronary artery bypass graft liver failure: a possible association with leflunomide.

  The Annals of thoracic surgery 20050201

• Severe bronchospasm after parenteral parecoxib: cyclooxygenase-2 inhibitors: not the answer yet.

  Anesthesiology 20050201

• Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources.

  Journal of neurochemistry 20050201

• Long-term open-label preliminary study of the safety and efficacy of leflunomide in patients with polyarticular-course juvenile rheumatoid arthritis.

  Arthritis and rheumatism 20050201

• A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients.

  The Journal of clinical psychiatry 20050201

• Mycotoxins revisited: Part II.

  The Journal of emergency medicine 20050201

• Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography.

  Electrophoresis 20050201

• Synthesis and evaluation of 2-[18F]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase.

  Nuclear medicine and biology 20050201

• Current concepts in nonoperative management of knee osteoarthritis.

  Orthopedics 20050201

• [Design, synthesis and insulin-sensitizing activity of some peroxisome proliferator-activated gamma agonists].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050201

• Rheumatoid arthritis: an update.

  Delaware medical journal 20050201

• [Leflunomide in the treatment of rheumatoid arthritis].

  La Tunisie medicale 20050201

• Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.

  The Journal of biological chemistry 20050128

• Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.

  Journal of medicinal chemistry 20050127

• Tolerance or accommodation: the lesson from leflunomide.

  Transplantation 20050127

• Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection.

  Transplantation 20050127

• Parecoxib, valdecoxib, and cardiovascular risk.

  Circulation 20050125

• Endothelin receptor antagonists for pulmonary arterial hypertension.

  The Cochrane database of systematic reviews 20050125

• Arthritis medicines and cardiovascular events--'house of coxibs'.

  JAMA 20050119

• Application of QSAR analysis to organic anion transporting polypeptide 1a5 (Oatp1a5) substrates.

  Bioorganic & medicinal chemistry 20050117

• Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle.

  Toxicology and applied pharmacology 20050115

• Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats.

  Transplantation 20050115

• Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system.

  Transplantation 20050115

• Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.

  Journal of medicinal chemistry 20050113

• When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide?

  Annals of the rheumatic diseases 20050101

• Endothelin-mediated remodeling in aortas of diabetic rats.

  Diabetes/metabolism research and reviews 20050101

• Six months open label trial of leflunomide in active ankylosing spondylitis.

  Annals of the rheumatic diseases 20050101

• Lupus erythematosus with leflunomide: induction or reactivation?

  Annals of the rheumatic diseases 20050101

• Selective cyclooxygenase-2 inhibition reverses microcirculatory and inflammatory sequelae of closed soft-tissue trauma in an animal model.

  The Journal of bone and joint surgery. American volume 20050101

• [The practice guideline 'Photo(chemo)therapy and systemic therapy in severe chronic plaque-psoriasis'].

  Nederlands tijdschrift voor geneeskunde 20050101

• Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778.

  Antiviral research 20050101

• Dose-dependent safety and efficacy of zonisamide: a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures.

  Epilepsia 20050101

• Molecular modeling study of leflunomide and its active metabolite analogues.

  Journal of chemical information and modeling 20050101

• Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050101

• Internalized GABA-receptor subunits are transferred to an intracellular pool associated with the postsynaptic density.

  The European journal of neuroscience 20050101

• Inhibition of human neuroblastoma cell growth by CAY10404, a highly selective Cox-2 inhibitor.

  Journal of neuro-oncology 20050101

• Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.

  Indian journal of experimental biology 20050101

• Valdecoxib for treatment of primary dysmenorrhea. A randomized, double-blind comparison with placebo and naproxen.

  Journal of general internal medicine 20050101

• Valdecoxib-induced systemic contact dermatitis confirmed by positive patch test.

  Contact dermatitis 20050101

• Tolerance of nonsteroidal anti-inflammatory drug-sensitive patients to the highly specific cyclooxygenase 2 inhibitors rofecoxib and valdecoxib.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050101

• Enhancement of dissolution rate of valdecoxib using solid dispersions with polyethylene glycol 4000.

  Drug development and industrial pharmacy 20050101

• Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons.

  Neuroscience 20050101

• Isoxazole ionotropic glutamate neurotransmitters.

  Current medicinal chemistry 20050101

• [New immunodepressant drugs for the prevention and control of kidney transplant rejection].

  Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20050101

• Effectiveness and safety profile of leflunomide in rheumatoid arthritis: actual practice compared with clinical trials.

  Clinical and experimental rheumatology 20050101

• [Guidelines for RA therapies].

  Nihon rinsho. Japanese journal of clinical medicine 20050101

• [Disease modifying anti-rheumatic drugs (DMARDs): an overview].

  Nihon rinsho. Japanese journal of clinical medicine 20050101

• [Leflunomide for therapy of rheumatoid arthritis].

  Nihon rinsho. Japanese journal of clinical medicine 20050101

• [Adverse effects of DMARDs in treatment of rheumatoid arthritis].

  Nihon rinsho. Japanese journal of clinical medicine 20050101

• Sentence ordered in drug counterfeiting case.

  FDA consumer 20050101

• FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506.

  Transplantation proceedings 20050101

• Zonisamide: a review of its use in the management of partial seizures in epilepsy.

  CNS drugs 20050101

• Zonisamide for absence seizures.

  Epilepsy research 20050101

• Modelling cost effectiveness and cost utility of sequential DMARD therapy including leflunomide in rheumatoid arthritis in Germany: I. Selected DMARDs and patient-related costs.

  PharmacoEconomics 20050101

• Modelling cost effectiveness and cost utility of sequential DMARD therapy including leflunomide for rheumatoid arthritis in Germany: II. The contribution of leflunomide to efficiency.

  PharmacoEconomics 20050101

• Valdecoxib for the management of chronic and acute pain.

  Expert review of neurotherapeutics 20050101

• Zonisamide: physician and patient experiences.

  Epilepsy research 20050101

• Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy.

  Clinical pharmacokinetics 20050101

• The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function.

  Arthritis research & therapy 20050101

• [Involvement of L-arginine-nitric oxide-cyclic GMP pathway in the peripheral antinociceptive effect induced by parecoxib].

  Cirugia y cirujanos 20050101

• Is there a rationale to using leflunomide in early rheumatoid arthritis?

  Clinical and experimental rheumatology 20050101

• Zonisamide in the treatment of painful diabetic neuropathy: a randomized, double-blind, placebo-controlled pilot study.

  Pain medicine (Malden, Mass.) 20050101

• COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective.

  Current topics in medicinal chemistry 20050101

• [Evaluation of rheumatoid arthritis activity in clinical practice].

  Terapevticheskii arkhiv 20050101

• [Experience in long-term therapy of active rheumatoid arthritis with leflunomide].

  Terapevticheskii arkhiv 20050101

• [Effective treatment of systemic sclerosis with leflunomide].

  Terapevticheskii arkhiv 20050101

• Regulatory paternalism in the market for drugs: lessons from Vioxx and Celebrex.

  Yale journal of health policy, law, and ethics 20050101

• Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation.

  Journal of andrology 20050101

• Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: therapeutic effects of nourishing 'Yin'-Removing 'Fire' Chinese herb mixture.

  Reproductive biology and endocrinology : RB&E 20050101

• In vivo metabolism for the hydroxylation of FK778 to the metabolite M3 in humans studied by enantioselective liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• FDA announces changes affecting the marketing of non-steroidal anti-inflammatory drugs.

  FDA consumer 20050101

• Successful treatment of SAPHO syndrome with leflunomide. Report of two cases.

  Clinical and experimental rheumatology 20050101

• Increased extracellular glutamate evoked by 1-methyl-4-phenylpyridinium [MPP(+)] in the rat striatum is not essential for dopaminergic neurotoxicity and is not derived from released glutathione.

  Neurotoxicity research 20050101

• Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors.

  Drug safety 20050101

• Efficacy of malononitrilamide FK778 in a preclinical model of small bowel transplantation.

  Transplantation proceedings 20050101

• Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV.

  Transplantation proceedings 20050101

• Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex.

  Epilepsy research 20050101

• Administration of leflunomide to a patient with rheumatoid arthritis on haemodialysis.

  Scandinavian journal of rheumatology 20050101

• Chemical and biochemical transformations of 5-ethoxycarbonyl-5-phenyl-2-isoxazolines.

  Farmaco (Societa chimica italiana : 1989) 20050101

• [Leflunomide: assessing teratogenic risk during the first trimester of pregnancy].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101

• [Cyclooxygenase-2 inhibitors and the ethics of research].

  Medicina 20050101

• [Use of low molecular weight heparin (Clexane) together with selective COX-2 inhibitor (Dynastat--once or twice per day)].

  Akusherstvo i ginekologiia 20050101

• Severe hepatotoxicity in a rheumatoid arthritis patient switched from leflunomide to methotrexate.

  MedGenMed : Medscape general medicine 20050101

• Laryngospasm and bronchospasm following parecoxib injections.

  Journal of pain & palliative care pharmacotherapy 20050101

• COX-2 inhibitors and heart.

  Indian heart journal 20050101

• Disease modifying treatment for feline rheumatoid arthritis.

  Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20050101

• Concern about one drug or entire class of drugs.

  Reumatizam 20050101

• COX-2 selective inhibitors and heart health.

  Postgraduate medicine 20050101

• FK778, a synthetic malononitrilamide.

  Yonsei medical journal 20041231

• Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation.

  Journal of the American Chemical Society 20041229

• Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.

  The Journal of biological chemistry 20041224

• Cardiovascular toxicity of valdecoxib.

  The New England journal of medicine 20041223

• Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents.

  Bioorganic & medicinal chemistry letters 20041220

• Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats.

  International immunopharmacology 20041215

• Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines.

  Bioorganic & medicinal chemistry 20041215

• FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation.

  Transplantation 20041215

• Modeling the 5-year cost effectiveness of treatment strategies including tumor necrosis factor-blocking agents and leflunomide for treating rheumatoid arthritis in the Netherlands.

  Arthritis and rheumatism 20041215

• Effect of soil properties on the degradation of isoxaflutole and the sorption-desorption of isoxaflutole and its diketonitrile degradate.

  Journal of agricultural and food chemistry 20041215

• Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection.

  Bone marrow transplantation 20041201

• Overview of Japanese experience-controlled and uncontrolled trials.

  Seizure 20041201

• Zonisamide monotherapy with once-daily dosing in children with cryptogenic localization-related epilepsies: clinical effects and pharmacokinetic studies.

  Seizure 20041201

• Review of zonisamide development in Japan.

  Seizure 20041201

• Effects of zonisamide monotherapy in children with epilepsy.

  Seizure 20041201

• Clinical efficacy of zonisamide in childhood epilepsy after long-term treatment: a postmarketing, multi-institutional survey.

  Seizure 20041201

• Efficacy of zonisamide: our experience.

  Seizure 20041201

• Zonisamide: chemistry, mechanism of action, and pharmacokinetics.

  Seizure 20041201

• Safety of zonisamide therapy: prospective follow-up survey.

  Seizure 20041201

• Zonisamide overview of the United States experience.

  Seizure 20041201

• Review of United States and European clinical trials of zonisamide in the treatment of refractory partial-onset seizures.

  Seizure 20041201

• Zonisamide clinical trials: European experience.

  Seizure 20041201

• Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs.

  Atherosclerosis 20041201

• Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells.

  Annals of the rheumatic diseases 20041201

• Reaction between parecoxib and vecuronium.

  Anaesthesia 20041201

• Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

  Nature medicine 20041201

• Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial.

  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20041201

• Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.

  Biological & pharmaceutical bulletin 20041201

• Effects of zonisamide on the electroencephalogram of a patient with juvenile myoclonic epilepsy.

  Epilepsy & behavior : E&B 20041201

• Serious dermatologic reaction associated with valdecoxib: report of two cases.

  Journal of the American Academy of Dermatology 20041201

• Induction of antinuclear antibodies in patients with rheumatoid arthritis treated with infliximab and leflunomide.

  Arthritis and rheumatism 20041201

• Novel immunosuppressants.

  Pediatric transplantation 20041201

• The broadening use of leflunomide in clinical practice.

  Hospital medicine (London, England : 1998) 20041201

• Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy.

  Epileptic disorders : international epilepsy journal with videotape 20041201

• [The specific cox-2 inhibitor valdecoxib provides effective analgesia after inguinal hernia surgery].

  Revista espanola de anestesiologia y reanimacion 20041201

• A cautionary note when using zonisamide in youths: a case report of association with toxic epidermal necrolysis.

  The Journal of clinical psychiatry 20041201

• Could Bextra increase heart risks too?

  Health news (Waltham, Mass.) 20041201

• Interstitial lung disease associated with leflunomide.

  Internal medicine (Tokyo, Japan) 20041201

• Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction.

  Internal medicine (Tokyo, Japan) 20041201

• Functional identification and monitoring of individual alpha and beta cells in cultured mouse islets of Langerhans.

  Acta diabetologica 20041201

• [Review of analgesics].

  Revue de l'infirmiere 20041201

• Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats.

  Methods and findings in experimental and clinical pharmacology 20041201

• The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein.

  The international journal of neuropsychopharmacology 20041201

• The 'alphabet' of rheumatoid arthritis treatment.

  Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20041201

• [Respiratory complications of new treatments for rheumatoid arthritis].

  Revue des maladies respiratoires 20041201

• A painkiller is pulled from the market. So what do you do now?

  Heart advisor 20041201

• Effect of zonisamide on the pharmacokinetics and pharmacodynamics of a combination ethinyl estradiol-norethindrone oral contraceptive in healthy women.

  Clinical therapeutics 20041201

• Search for new lead structures for low-molecular-weight immune response modifiers.

  Acta poloniae pharmaceutica 20041201

• Structure and immunological activity of disubstituted thiosemicarbazide isoxazole derivative.

  Acta poloniae pharmaceutica 20041201

• New synthetic equivalent of nitromalonaldehyde treatable in organic media.

  The Journal of organic chemistry 20041126

• An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

  Journal of medicinal chemistry 20041118

• Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology.

  Bioorganic & medicinal chemistry letters 20041115

• Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

  Bioorganic & medicinal chemistry letters 20041115

• Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

• Patient preferences for treatment of rheumatoid arthritis.

  Annals of the rheumatic diseases 20041101

• Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion.

  Journal of leukocyte biology 20041101

• NK95806, a newly synthesized microtubule-disrupting agent that suppresses collagen-induced arthritis in mice.

  International immunopharmacology 20041101

• CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase.

  Leukemia 20041101

• Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB.

  Hepatology (Baltimore, Md.) 20041101

• High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition.

  Clinica chimica acta; international journal of clinical chemistry 20041101

• Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy.

  Journal of clinical pharmacology 20041101

• Sitaxsentan, a selective endothelin-A receptor antagonist for the treatment of pulmonary arterial hypertension.

  Expert opinion on investigational drugs 20041101

• Do guidelines for the prescribing and monitoring of leflunomide need to be modified?

  Rheumatology (Oxford, England) 20041101

• Pulmonary hypertension in a patient with rheumatoid arthritis treated with leflunomide.

  Rheumatology (Oxford, England) 20041101

• Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients.

  Epilepsy research 20041101

• Zonisamide and associated oligohidrosis and hyperthermia.

  Epilepsy research 20041101

• Postmarketing surveillance for drug safety.

  Clinical pharmacology and therapeutics 20041101

• Damage control in rheumatoid arthritis. Hard-hitting, early treatment is crucial to curbing joint destruction.

  Postgraduate medicine 20041101

• [The active metabolite of leflunomide A771726 inhibits proliferation and collagen synthesis of hepatic stellate cell].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20041101

• The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain.

  Journal of the American Dental Association (1939) 20041101

• Zonisamide: newer antiepileptic agent with multiple mechanisms of action.

  Expert review of neurotherapeutics 20041101

• Pfizer criticised over delay in admitting drug's problems.

  BMJ (Clinical research ed.) 20041023

• Coxibs and cardiovascular disease.

  The New England journal of medicine 20041021

• Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists.

  Bioorganic & medicinal chemistry letters 20041018

• GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.

  Biochemical pharmacology 20041015

• Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.

  Journal of medicinal chemistry 20041007

• Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects.

  Acta anaesthesiologica Scandinavica 20041001

• Efficacy and safety of valdecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials.

  Pain 20041001

• Acute treatment of bipolar depression with adjunctive zonisamide: a retrospective chart review.

  Bipolar disorders 20041001

• Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.

  Pharmacogenetics 20041001

• Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy.

  European journal of pharmacology 20041001

• Adverse events with disease modifying antirheumatic drugs (DMARD): a cohort study of leflunomide compared with other DMARD.

  The Journal of rheumatology 20041001

• Vasculitis associated with the use of leflunomide.

  The Journal of rheumatology 20041001

• Life-threatening hypertriglyceridemia during leflunomide therapy in a patient with rheumatoid arthritis.

  Arthritis and rheumatism 20041001

• Sustained symptomatic, functional, and hemodynamic benefit with the selective endothelin-A receptor antagonist, sitaxsentan, in patients with pulmonary arterial hypertension: a 1-year follow-up study.

  Chest 20041001

• Leflunomide in psoriasis and psoriatic arthritis: a preliminary study.

  Archives of dermatology 20041001

• A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy.

  American journal of obstetrics and gynecology 20041001

• Anticonvulsant drugs in primary headaches prophylaxis.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001

• Antimetabolites in the treatment of arthritis: current status of the use of antimetabolites.

  Nucleosides, nucleotides & nucleic acids 20041001

• Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells.

  Nucleosides, nucleotides & nucleic acids 20041001

• Comparison of anti-arthritic properties of leflunomide with methotrexate and FK506: effect on T cell activation-induced inflammatory cytokine production in vitro and rat adjuvant-induced arthritis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20041001

• The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic anhydrase II.

  Inflammation 20041001

• Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal.

  Journal of medicinal chemistry 20040923

• A rapid and simple determination of A77 1726 in human serum by high-performance liquid chromatography and its application for optimization of leflunomide therapy.

  Journal of pharmaceutical and biomedical analysis 20040921

• Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.

  Bioorganic & medicinal chemistry letters 20040920

• Catalysis by hydrophobically modified poly(propylenimine) dendrimers having quaternary ammonium and tertiary amine functionality.

  Langmuir : the ACS journal of surfaces and colloids 20040914

• Stability study of amorphous valdecoxib.

  International journal of pharmaceutics 20040910

• [When to begin rheumatism treatment? Initial combination therapy helps fastest].

  MMW Fortschritte der Medizin 20040909

• [Three joints swollen, blood sedimentation increased. Methotrexate to be given immediately?].

  MMW Fortschritte der Medizin 20040909

• Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis.

  Annals of the rheumatic diseases 20040901

• Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.

  The Journal of pharmacology and experimental therapeutics 20040901

• Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices.

  Neuropharmacology 20040901

• In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.

  British journal of pharmacology 20040901

• Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1beta stimulated rheumatoid synovial fibroblasts.

  Clinical and experimental immunology 20040901

• Patients' global evaluation of analgesia and safety of injected parecoxib for postoperative pain: a quantitative systematic review.

  Anesthesia and analgesia 20040901

• Reduced incidence of upper gastrointestinal ulcer complications with the COX-2 selective inhibitor, valdecoxib.

  Alimentary pharmacology & therapeutics 20040901

• 'Fast-track' drug approvals hit speed bumps in Japan.

  Nature medicine 20040901

• A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasma.

  Journal of analytical toxicology 20040901

• [Psoriasis arthritis--long-term treatment of two patients with leflunomide].

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20040901

• Physiological ligands ADP and Pi modulate the degree of intrinsic coupling in the ATP synthase of the photosynthetic bacterium Rhodobacter capsulatus.

  Biochemistry 20040831

• Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040801

• Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.

  Journal of clinical gastroenterology 20040801

• Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.

  Chirality 20040801

• Synthesis and biological evaluation of novel T-type Ca2+ channel blockers.

  Bioorganic & medicinal chemistry 20040801

• Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4(+) T lymphocytes.

  Virology 20040801

• Leflunomide in active rheumatoid arthritis: a prospective study in daily practice.

  British journal of clinical pharmacology 20040801

• Plasma risperidone concentrations during combined treatment with sertraline.

  Therapeutic drug monitoring 20040801

• Dialyzability of the antiepileptic drug zonisamide in patients undergoing hemodialysis.

  Epilepsia 20040801

• First and second generations of COX-2 selective inhibitors.

  Mini reviews in medicinal chemistry 20040801

• Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial.

  The Journal of rheumatology 20040801

• Effects of valdecoxib in the treatment of chronic low back pain: results of a randomized, placebo-controlled trial.

  Clinical therapeutics 20040801

• In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis.

  Clinical therapeutics 20040801

• Novel delta2-isoxazolines as group II phospholipase A2 inhibitors.

  Bioorganic & medicinal chemistry letters 20040716

• Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis.

  The American journal of medicine 20040715

• FK778: a powerful immunosuppressive, but will it really be good for you?

  Transplantation 20040715

• The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients.

  Transplantation 20040715

• FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.

  Transplantation 20040715

• Accuracy of splitting unscored valdecoxib tablets.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040715

• Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis.

  Dermatology online journal 20040715

• Stereochemically rich pentaketides from bis(isoxazolines): a general strategy for efficient polyketide synthesis.

  Organic letters 20040708

• Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles.

  Journal of the American Chemical Society 20040707

• Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma.

  Cancer chemotherapy and pharmacology 20040701

• Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats.

  Acta pharmacologica Sinica 20040701

• Peripheral neuropathy in patients on leflunomide.

  Rheumatology (Oxford, England) 20040701

• Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

  Journal of medicinal chemistry 20040701

• Extraarticular rheumatoid arthritis and drug-induced syndromes: understanding the role of tumor necrosis factor inhibitors.

  The Journal of rheumatology 20040701

• Reversal of the inhibition of photosynthesis by herbicides affecting hydroxyphenylpyruvate dioxygenase by plastoquinone and tocopheryl derivatives in Chlamydomonas reinhardtii.

  Pest management science 20040701

• The analgesic effects that underlie patient satisfaction with treatment.

  Pain 20040701

• Therapeutic interchange involving replacement of rofecoxib or celecoxib with valdecoxib.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040701

• Gaboxadol. Lundbeck/Merck.

  Current opinion in investigational drugs (London, England : 2000) 20040701

• One step regioselective synthesis of 5-aminoisoxazoles from nitrile oxides and alpha-cyanoenamines.

  Molecules (Basel, Switzerland) 20040630

• The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones.

  Bioorganic & medicinal chemistry letters 20040621

• In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.

  Bioorganic & medicinal chemistry letters 20040621

• The Kemp elimination in membrane mimetic reaction media. Probing catalytic properties of cationic vesicles formed from a double-tailed amphiphile and linear long-tailed alcohols or alkyl pyranosides.

  Organic & biomolecular chemistry 20040621

• [Methotrexate combined with leflunomide or hydroxychloroquine in the treatment of rheumatoid arteritis].

  Zhonghua yi xue za zhi 20040617

• Decarboxylation of 6-nitrobenzisoxazole-3-carboxylate as kinetic probe for piperazinium-based cationic micelles.

  Journal of colloid and interface science 20040615

• Unprecedented in situ oxidative ring cleavage of isoxazolidines: diastereoselective transformation of nitronic acids and derivatives into 3-hydroxymethyl 4-nitro tetrahydrofurans and pyrrolidines.

  Organic letters 20040610

• Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.

  Bioorganic & medicinal chemistry letters 20040607

• [Diagnosis and therapy of rheumatoid arthritis].

  Deutsche medizinische Wochenschrift (1946) 20040604

• Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunits.

  The Journal of pharmacology and experimental therapeutics 20040601

• Pediatric phase I trial and pharmacokinetic study of the platelet-derived growth factor (PDGF) receptor pathway inhibitor SU101.

  Cancer chemotherapy and pharmacology 20040601

• Efficacy and safety of leflunomide 10 mg versus 20 mg once daily in patients with active rheumatoid arthritis: multinational double-blind, randomized trial.

  Rheumatology (Oxford, England) 20040601

• Zonisamide monotherapy in a multi-group clinic.

  Seizure 20040601

• Early analgesic effects of parecoxib versus ketorolac following laparoscopic sterilization: a randomized controlled trial.

  British journal of anaesthesia 20040601

• Long term evaluation of radiographic disease progression in a subset of patients with rheumatoid arthritis treated with leflunomide beyond 2 years.

  Annals of the rheumatic diseases 20040601

• Dose escalation of leflunomide (LEF) to 40 mg once daily in patients with rheumatoid arthritis and insufficient response to standard dose LEF.

  Annals of the rheumatic diseases 20040601

• Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures.

  Epilepsia 20040601

• Leflunomide in active rheumatoid arthritis: a prospective study in daily practice.

  British journal of clinical pharmacology 20040601

• Systematic review of the analgesic efficacy and tolerability of COX-2 inhibitors in post-operative pain control.

  Journal of clinical pharmacy and therapeutics 20040601

• Preoperative parenteral parecoxib and follow-up oral valdecoxib reduce length of stay and improve quality of patient recovery after laparoscopic cholecystectomy surgery.

  Anesthesia and analgesia 20040601

• Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells.

  World journal of gastroenterology 20040601

• Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase.

  Nuclear medicine communications 20040601

• Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040601

• Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.

  Journal of neural transmission (Vienna, Austria : 1996) 20040601

• The efficacy of leflunomide monotherapy in rheumatoid arthritis: towards the goals of disease modifying antirheumatic drug therapy.

  The Journal of rheumatology. Supplement 20040601

• Leflunomide: a manageable safety profile.

  The Journal of rheumatology. Supplement 20040601

• Lefunomide in combination therapy.

  The Journal of rheumatology. Supplement 20040601

• What I would like to know about leflunomide.

  The Journal of rheumatology 20040601

• Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives.

  Farmaco (Societa chimica italiana : 1989) 20040601

• Peripheral neuropathy in patients treated with leflunomide.

  Clinical pharmacology and therapeutics 20040601

• Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo-controlled clinical trial.

  Arthritis and rheumatism 20040601

• Safety of 25- and 50-mg capsules in the initiation of zonisamide therapy in patients with epilepsy: an uncontrolled, open-label study.

  Current medical research and opinion 20040601

• Leflunomide as a novel treatment option in severe atopic dermatitis.

  The British journal of dermatology 20040601

• Parecoxib: new preparation. A NSAID for postoperative pain: no proven advantage.

  Prescrire international 20040601

• QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations.

  Journal of psychopharmacology (Oxford, England) 20040601

• New pharmacotherapies for pediatric seizures.

  Pediatric annals 20040601

• The farnesoid X receptor induces very low density lipoprotein receptor gene expression.

  FEBS letters 20040521

• New drugs for rheumatoid arthritis.

  The New England journal of medicine 20040520

• Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.

  The Biochemical journal 20040515

• Leflunomide therapy for cytomegalovirus disease in renal allograft recepients.

  Transplantation 20040515

• New drugs to improve transplant outcomes.

  Transplantation 20040515

• Safety of newer antiepileptic drugs.

  JAMA 20040505

• Parecoxib for parenteral analgesia in postsurgical patients.

  The Annals of pharmacotherapy 20040501

• Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes.

  British journal of clinical pharmacology 20040501

• Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20040501

• Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.

  Epilepsia 20040501

• Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.

  Epilepsia 20040501

• A systematic review of COX-2 inhibitors compared with traditional NSAIDs, or different COX-2 inhibitors for post-operative pain.

  Acta anaesthesiologica Scandinavica 20040501

• Parecoxib sodium, an injectable COX-2-specific inhibitor, does not affect unfractionated heparin-regulated blood coagulation parameters.

  Journal of clinical pharmacology 20040501

• Chronic overdose of leflunomide inducing interstitial nephritis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040501

• Subacute cutaneous lupus erythematosus associated with leflunomide.

  Clinical and experimental dermatology 20040501

• Valdecoxib versus rofecoxib in acute postsurgical pain: results of a randomized controlled trial.

  Journal of pain and symptom management 20040501

• Glycoprotein IIb/IIIa inhibitors increase COAT-platelet production in vitro.

  The Journal of laboratory and clinical medicine 20040501

• The plasma membrane of microaerophilic protists: oxidative and nitrosative stress.

  Microbiology (Reading, England) 20040501

• Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital.

  Current medical research and opinion 20040501

• Leflunomide in the treatment of psoriasis: results of a phase II open trial.

  The British journal of dermatology 20040501

• Safety overview of new disease-modifying antirheumatic drugs.

  Rheumatic diseases clinics of North America 20040501

• Overview of radiologic efficacy of new treatments.

  Rheumatic diseases clinics of North America 20040501

• Leflunomide.

  Rheumatic diseases clinics of North America 20040501

• Leflunomide-induced aseptic meningitis.

  Joint, bone, spine : revue du rhumatisme 20040501

• Role of parecoxib in pre-emptive analgesia: comparison of the efficacy and safety of pre- and postoperative parecoxib in patients undergoing general surgery.

  Journal of the Indian Medical Association 20040501

• Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society.

  Neurology 20040427

• Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.

  European journal of pharmacology 20040426

• Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.

  The Journal of biological chemistry 20040423

• Investigation of conjugate addition/intramolecular nitrone dipolar cycloadditions and their use in the synthesis of dendrobatid alkaloid precursors.

  Organic & biomolecular chemistry 20040421

• Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.

  International journal of cancer 20040420

• Catalytic asymmetric synthesis of glutamate analogues.

  Organic letters 20040415

• The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis.

  Arthritis and rheumatism 20040415

• Interstitial lung disease and disease modifying anti-rheumatic drugs.

  Lancet (London, England) 20040410

• Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.

  Journal of medicinal chemistry 20040408

• Quantitation of Valdecoxib in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection using liquid-liquid extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405

• Correlation between scores on Continuous Performance Test and plasma concentration for schizophrenic patients on risperidone.

  Psychiatry and clinical neurosciences 20040401

• Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activities.

  Biochemical pharmacology 20040401

• Synergistic drug combinations against the in vitro replication of Coxsackie B1 virus.

  Antiviral research 20040401

• 3D QSAR studies on T-type calcium channel blockers using CoMFA and CoMSIA.

  Bioorganic & medicinal chemistry 20040401

• Successful use of zonisamide for central poststroke pain.

  The journal of pain : official journal of the American Pain Society 20040401

• [Valdecoxib (Bextra)].

  Revue medicale de Liege 20040401

• Leflunomide in the treatment of rheumatoid arthritis.

  Clinical therapeutics 20040401

• Inactivation of human liver arginase by Woodward's reagent K: evidence for reaction with His141.

  The protein journal 20040401

• A 771726, the active metabolite of leflunomide, inhibits TNF-alpha and IL-1 from Kupffer cells.

  Inflammation 20040401

• The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum.

  The Journal of biological chemistry 20040319

• Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.

  Biochemical pharmacology 20040315

• Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.

  Journal of medicinal chemistry 20040311

• The complete characterization of a rhodium Lewis acid-dipolarophile complex as an intermediate for the enantioselective catalytic 1,3-dipolar cycloaddition of C,N-diphenylnitrone to methacrolein.

  Journal of the American Chemical Society 20040310

• [Collagen diseases and rheumatic diseases].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040310

• Solid-phase synthesis of 5-isoxazol-4-yl-[1,2,4]oxadiazoles.

  The Journal of organic chemistry 20040305

• Effects of brassinazole, an inhibitor of brassinosteroid biosynthesis, on light- and dark-grown Chlorella vulgaris.

  Planta 20040301

• Estradiol and testosterone modulate the anesthetic action of the GABA-A agonist THIP, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat.

  Psychopharmacology 20040301

• Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis.

  Arteriosclerosis, thrombosis, and vascular biology 20040301

• Histological and immunological characteristics of, and the effect of immunosuppressive treatment on, xenograft vasculopathy.

  Xenotransplantation 20040301

• Maintenance of remission with leflunomide in Wegener's granulomatosis.

  Rheumatology (Oxford, England) 20040301

• Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.

  British journal of pharmacology 20040301

• The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1.

  Arthritis and rheumatism 20040301

• Additive effects of leflunomide and tacrolimus in prevention of islet xenograft rejection.

  Scandinavian journal of immunology 20040301

• [Clinical guidelines for treatment of epilepsy in children].

  No to hattatsu = Brain and development 20040301

• Collision-induced dissociation of valdecoxib metabolites: a novel rearrangement involving an isoxazole ring.

  Journal of mass spectrometry : JMS 20040301

• The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans.

  Pain 20040301

• Leflunomide for chronic sarcoidosis.

  Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 20040301

• Parecoxib: a shift in pain management?

  Expert review of neurotherapeutics 20040301

• The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.

  Transplantation 20040227

• Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.

  Bioorganic & medicinal chemistry letters 20040223

• Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.

  The Journal of biological chemistry 20040220

• Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells.

  Experimental cell research 20040215

• Selective or nonselective endothelin receptor blockade in pulmonary arterial hypertension.

  American journal of respiratory and critical care medicine 20040215

• Weekly leflunomide as monotherapy for recent-onset rheumatoid arthritis.

  Arthritis and rheumatism 20040215

• Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.

  The Journal of biological chemistry 20040213

• Quantification of risperidone and 9-hydroxyrisperidone in plasma and saliva from adult and pediatric patients by liquid chromatography-mass spectrometry.

  Journal of chromatography. A 20040213

• Japan deaths spark concerns over arthritis drug.

  Lancet (London, England) 20040207

• The new antiepileptic drugs: scientific review.

  JAMA 20040204

• Zonisamide-induced depression and mania in patients with epilepsy.

  Journal of clinical psychopharmacology 20040201

• The endothelin system in pulmonary arterial hypertension.

  Cardiovascular research 20040201

• Leflunomide (Arava)-induced cystoid macular oedema.

  Rheumatology (Oxford, England) 20040201

• Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor.

  Anesthesia and analgesia 20040201

• Transfer of risperidone and 9-hydroxyrisperidone into human milk.

  The Annals of pharmacotherapy 20040201

• Glutamate regulates Oct-2 DNA-binding activity through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors in cultured chick Bergmann glia cells.

  Journal of neurochemistry 20040201

• Rheumatological creativity and leflunomide.

  The Journal of rheumatology 20040201

• Rheumatoid arthritis treatment with weekly leflunomide: an open-label study.

  The Journal of rheumatology 20040201

• Gamma-glutamyl transpeptidase inhibition suppresses milk protein synthesis in isolated ovine mammary cells.

  Journal of dairy science 20040201

• Reporting of clinical trials of analgesia.

  The Journal of thoracic and cardiovascular surgery 20040201

• Structure/activity investigations of 5-substituted 3-methylisoxazole[5, 4-d]1, 2, 3-triazin-4-one derivatives.

  Archiv der Pharmazie 20040201

• [Contribution of leflunomide to the cost effectiveness of sequential DMARD therapy of rheumatoid arthritis in Germany].

  Zeitschrift fur Rheumatologie 20040201

• [Development and/or increase of rheumatoid nodules in RA patients following leflunomide therapy].

  Zeitschrift fur Rheumatologie 20040201

• [High throughput screening method of potassium channel regulators].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040201

• Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.

  Journal of medicinal chemistry 20040129

• Zonisamide treatment for symptomatic infantile spasms.

  Neurology 20040127

• A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

  Organic & biomolecular chemistry 20040121

• Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.

  Journal of medicinal chemistry 20040115

• Homoepiboxidines: further potent agonists for nicotinic receptors.

  Bioorganic & medicinal chemistry 20040102

• One-pot synthesis of functionalized 4,5-dihydroisoxazole derivatives via nitrile oxides and biological evaluation with plant cells.

  Bioorganic & medicinal chemistry 20040102

• Synthesis and pharmacological assessment of derivatives of isoxazolo[4,5-d]pyrimidine.

  Bioorganic & medicinal chemistry 20040102

• Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.

  British journal of pharmacology 20040101

• Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells.

  Antiviral research 20040101

• Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20040101

• Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.

  Pain 20040101

• Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines.

  Cancer biology & therapy 20040101

• Leflunomide and anti-glomerular basement membrane glomerulonephritis: comment on the letter by Bruyn et al.

  Arthritis and rheumatism 20040101

• Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial.

  The Journal of clinical psychiatry 20040101

• Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.

  Farmaco (Societa chimica italiana : 1989) 20040101

• Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease.

  Current pharmaceutical design 20040101

• Leflunomide-induced acute hepatitis.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20040101

• [Drug safety. Notes about surveillance].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101

• Effect of selective inhibition of cyclooxygenase-2 on lipopolysaccharide-induced hyperalgesia.

  Inflammopharmacology 20040101

• Prevalence of antimicrobial resistance in bacteria isolated from central nervous system specimens as reported by U.S. hospital laboratories from 2000 to 2002.

  Annals of clinical microbiology and antimicrobials 20040101

• Leflunomide for the treatment of rheumatoid arthritis in clinical practice: incidence and severity of hepatotoxicity.

  Drug safety 20040101

• Photodistributed lichenoid drug eruption with rhabdomyolysis occurring during leflunomide therapy.

  Dermatology (Basel, Switzerland) 20040101

• An unusual overdose of leflunomide in a patient with rheumatoid arthritis.

  The Annals of pharmacotherapy 20040101

• A mechanistic perspective on the specificity and extent of COX-2 inhibition in pregnancy.

  Drug safety 20040101

• The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes.

  Arthritis research & therapy 20040101

• Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implications.

  Journal of child and adolescent psychopharmacology 20040101

• Safety of leflunomide plus infliximab combination therapy in rheumatoid arthritis.

  Clinical and experimental rheumatology 20040101

• New immunosuppressive strategies in renal transplant recipients.

  Journal of nephrology 20040101

• Analgesic efficacy of preoperative parecoxib sodium in an orthopedic pain model.

  Journal of the American Podiatric Medical Association 20040101

• Valdecoxib: a review of its use in the management of osteoarthritis, rheumatoid arthritis, dysmenorrhoea and acute pain.

  Drugs 20040101

• Leflunomide-associated pancytopenia with or without methotrexate.

  The Annals of pharmacotherapy 20040101

• The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage.

  Journal of bone and mineral metabolism 20040101

• [Changes in indices of inflammatory activity in patients with rheumatoid arthritis during early stages of basic therapy with leflunomide].

  Terapevticheskii arkhiv 20040101

• Leflunomide: a novel disease modifying anti-rheumatic drug.

  Journal of postgraduate medicine 20040101

• Zonisamide therapy for refractory idiopathic epilepsy in dogs.

  Journal of the American Animal Hospital Association 20040101

• Newer anticonvulsants in the treatment of bipolar disorder.

  The Journal of clinical psychiatry 20040101

• Antiepileptic drugs in migraine prophylaxis: state of the art.

  La Clinica terapeutica 20040101

• Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis.

  American journal of therapeutics 20040101

• Pharmacologic treatment of the catastrophic epilepsies.

  Epilepsia 20040101

• [Treatment of Wegener's granulomatosis].

  Reumatismo 20040101

• [Updated treatment of primary pulmonary hypertension -- the role of endothelin receptor antagonists].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101

• Psoriatic arthritis.

  Dermatologic therapy 20040101

• Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus.

  Lupus 20040101

• Cooperation in signal transduction of extracellular guanosine 5' triphosphate and nerve growth factor in neuronal differentiation of PC12 cells.

  Neuroscience 20040101

• Surveillance of antimicrobial resistance at a tertiary hospital in Tanzania.

  BMC public health 20040101

• Parecoxib impairs early tendon repair but improves later remodeling.

  The American journal of sports medicine 20040101

• Clomazone dissipation, adsorption and translocation in four paddy topsoils.

  Journal of environmental sciences (China) 20040101

• [Current EULAR data on valdecoxib. New study results of gastrointestinal safety and 'cost effectiveness'].

  Krankenpflege Journal 20040101

• Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice.

  Stem cells (Dayton, Ohio) 20040101

• Interrelationship of macropores and subsurface drainage for conservative tracer and pesticide transport.

  Journal of environmental quality 20040101

• New hope for patients with pulmonary hypertension: endothelin receptor antagonists: update for the clinical nurse specialist.

  Clinical nurse specialist CNS 20040101

• Evidence-based evaluation of immunomodulatory therapy for the cutaneous manifestations of lupus.

  Advances in dermatology 20040101

• Benefit/risk of leflunomide in rheumatoid arthritis.

  Clinical and experimental rheumatology 20040101

• [Some new drugs: valdecoxib (Betra), voriconazole (Vfend), ezetimide (Ezetrol), teriparatide (Forsteo)].

  Journal de pharmacie de Belgique 20040101

• [Basic therapy of rheumatoid arthritis with leflunomide (review)].

  Terapevticheskii arkhiv 20040101

• Open-label zonisamide for refractory migraine.

  Clinical neuropharmacology 20040101

• Degradation of RPA 202248 [U-14C-phenyl]alpha(-(cyclopropylcarbonyl)-2-(methylsulfonyl)-beta-oxo-4-(trifluromethyl)benzenepropanenitrile), the primary degradation product of isoxaflutole, in an outdoor aquatic microcosm system.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20040101

• Induction of autoantibodies in refractory rheumatoid arthritis treated by infliximab.

  Clinical and experimental rheumatology 20040101

• Effectiveness and safety of infliximab combined with leflunomide in chronic polyarthritis.

  Clinical and experimental rheumatology 20040101

• Degradation of isoxaflutole (balance) herbicide by hypochlorite in tap water.

  Journal of agricultural and food chemistry 20031231

• 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.

  Journal of medicinal chemistry 20031218

• Rotarod studies in the rat of the GABAA receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance.

  European journal of pharmacology 20031215

• Leflunomide use during the first 33 months after food and drug administration approval: experience with a national cohort of 3,325 patients.

  Arthritis and rheumatism 20031215

• Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.

  Transplantation 20031215

• Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.

  Journal of medicinal chemistry 20031204

• 1,2-benzisoxazole phosphorodiamidates as novel anticancer prodrugs requiring bioreductive activation.

  Journal of medicinal chemistry 20031204

• Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.

  American journal of physiology. Heart and circulatory physiology 20031201

• T cell aggregation induced through CD43: intracellular signals and inhibition by the immunomodulatory drug leflunomide.

  Journal of leukocyte biology 20031201

• Pharmacological actions of a novel and selective dopamine D3 receptor antagonist, KCH-1110.

  Pharmacological research 20031201

• The role of cyclooxygenase selective inhibitors in the gastrointestinal tract.

  Current gastroenterology reports 20031201

• Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.

  The Journal of clinical investigation 20031201

• Novel therapies in pediatric rheumatic diseases.

  Current opinion in pediatrics 20031201

• Intra- and interindividual variations in steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients treated chronically with various doses of risperidone.

  Therapeutic drug monitoring 20031201

• Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor.

  Biological & pharmaceutical bulletin 20031201

• [Clinical pharmacology of the selective COX-2 inhibitors].

  Der Orthopade 20031201

• Efficacy and safety of leflunomide and predisposing factors for treatment response in patients with active rheumatoid arthritis: RELIEF 6-month data.

  The Journal of rheumatology 20031201

• Evaluation of the efficacy, safety and tolerability of valdecoxib gel (1%) in adult patients with painful inflammatory joint disease.

  Journal of the Indian Medical Association 20031201

• Use of selenium-bound resin for the solid-phase synthesis of substituted isoxazolyl-substituted (E)-olefins.

  Organic letters 20031127

• Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents.

  Bioorganic & medicinal chemistry letters 20031117

• Aza-THIP and related analogues of THIP as GABA C antagonists.

  Bioorganic & medicinal chemistry 20031117

• Endothelin receptor blockers in cardiovascular disease.

  Circulation 20031104

• The burden of acute postoperative pain and the potential role of the COX-2-specific inhibitors.

  Rheumatology (Oxford, England) 20031101

• Economic evaluation of oral valdecoxib versus diclofenac in the treatment of patients with rheumatoid arthritis in a randomized clinical trial.

  Rheumatology (Oxford, England) 20031101

• Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20031101

• Transport of Cl- across the plasma membrane during pollen grain germination in tobacco.

  Biochemistry. Biokhimiia 20031101

• Light and clomazone effects on tobacco (Nicotiana tabacum) callus and leaf discs.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20031101

• Exfoliative dermatitis induced by leflunomide therapy.

  The Journal of dermatology 20031101

• Synthesis of cyclic and acyclic beta-amino acids via chelation-controlled 1,3-dipolar cycloaddition.

  The Journal of organic chemistry 20031031

• [Pain therapy in rheumatism. After 65 years of age coxibs are the best choice].

  MMW Fortschritte der Medizin 20031016

• Solution-phase synthesis of novel delta2-isoxazoline libraries via 1,3-dipolar cycloaddition and their antifungal properties.

  Bioorganic & medicinal chemistry 20031015

• [Emergence of new therapeutic agents for collagen diseases and some of the problems].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20031010

• Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of gastroduodenal ulcers: results of a 26-week trial.

  Rheumatology (Oxford, England) 20031001

• Survival and effectiveness of leflunomide compared with methotrexate and sulfasalazine in rheumatoid arthritis: a matched observational study.

  Annals of the rheumatic diseases 20031001

• In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes.

  Drug metabolism and disposition: the biological fate of chemicals 20031001

• Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.

  Molecular pharmacology 20031001

• Enantioselective synthesis of alpha,beta-disubstituted-beta-amino acids.

  Journal of the American Chemical Society 20031001

• Effects of rofecoxib, celecoxib, and parecoxib on anti-IgE-induced histamine release from human skin mast cells and basophils.

  Allergy 20031001

• Correlation between clinical response to treatment and radiographic progression: comment on the article by Strand and Sharp.

  Arthritis and rheumatism 20031001

• COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.

  Laboratory investigation; a journal of technical methods and pathology 20031001

• Acivicin induce filamentous growth of Saccharomyces cerevisiae.

  Bioscience, biotechnology, and biochemistry 20031001

• Effect of antiepileptic drug monotherapy on crystalluria in children and young adults.

  Journal of neurology 20031001

• Stability of reconstituted parecoxib for injection with commonly used diluents.

  Journal of clinical pharmacy and therapeutics 20031001

• 4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target.

  Drug news & perspectives 20031001

• Evidence for inhibitory effect of the agonist gaboxadol at human alpha 1 beta 2 gamma 2S GABAA receptors.

  European journal of pharmacology 20030930

• Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity.

  Organic & biomolecular chemistry 20030921

• Development and validation of an automated SPE-LC-MS/MS assay for valdecoxib and its hydroxylated metabolite in human plasma.

  Journal of pharmaceutical and biomedical analysis 20030915

• Human rhinovirus capsid dynamics is controlled by canyon flexibility.

  Virology 20030915

• One- and two-step spin-crossover behavior of [Fe(II)(isoxazole)(6)](2+) and the structure and magnetic properties of triangular [Fe(III)(3)O(OAc)(6)(isoxazole)(3)][ClO(4)].

  Inorganic chemistry 20030908

• Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm.

  Psychopharmacology 20030901

• Is the recommended dose of leflunomide the best regimen to treat rheumatoid arthritis patients?

  Rheumatology (Oxford, England) 20030901

• Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension.

  Journal of hypertension 20030901

• [New drugs and treatment strategies for rheumatoid arthritis].

  Recenti progressi in medicina 20030901

• Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20030901

• Valdecoxib, a COX-2-specific inhibitor, does not affect cardiac repolarization.

  Journal of clinical pharmacology 20030901

• Is leflunomide as safe and effective in the treatment of rheumatoid arthritis as other DMARDs?

  American family physician 20030901

• Effects of leflunomide on human cartilage.

  Farmaco (Societa chimica italiana : 1989) 20030901

• Development of resistance to disoxaril in Coxsackie B1 virus-infected newborn mice.

  Antiviral research 20030901

• Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.

  Molecular and cellular neurosciences 20030901

• Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity.

  Bioorganic & medicinal chemistry letters 20030901

• Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain.

  The American journal of geriatric pharmacotherapy 20030901

• Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures.

  Brain research. Molecular brain research 20030819

• Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor.

  Bioorganic & medicinal chemistry letters 20030818

• Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.

  Bioorganic & medicinal chemistry letters 20030818

• Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection.

  Transplantation 20030815

• Enantioselective syntheses and cytotoxicity of N,O-nucleosides.

  Journal of medicinal chemistry 20030814

• Human kininogen gene is transactivated by the farnesoid X receptor.

  The Journal of biological chemistry 20030801

• Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20030801

• Leflunomide in Crohn's disease--the open-label case series and the Texas sharpshooter.

  Journal of clinical gastroenterology 20030801

• Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy.

  Journal of clinical gastroenterology 20030801

• Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

  Gastroenterology 20030801

• Toward a definition and method of assessment of treatment failure and treatment effectiveness: the case of leflunomide versus methotrexate.

  The Journal of rheumatology 20030801

• Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trial.

  Chinese medical journal 20030801

• [Effect of zonisamide on resting tremor resistant to antiparkinsonian medication].

  No to shinkei = Brain and nerve 20030801

• S-nitrosylation signaling in cell biology.

  Molecular interventions 20030801

• Anti-HIV-1 activity of leflunomide: a comparison with mycophenolic acid and hydroxyurea.

  AIDS (London, England) 20030725

• [Tolerable pain therapy in rheumatism saves long-term costs. Despite this most COX-2 candidates receive conventional NSAID therapy].

  MMW Fortschritte der Medizin 20030724

• Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors.

  Life sciences 20030718

• An investigation of the Lewis acid mediated 1,3-dipolar cycloaddition between N-benzyl-C-(2-pyridyl)nitrone and allylic alcohol. Direct entry to isoxazolidinyl C-nucleosides.

  Organic & biomolecular chemistry 20030707

• Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.

  Journal of medicinal chemistry 20030703

• Differential effects of pulsatile versus steady flow on coronary endothelial membrane potential.

  American journal of physiology. Heart and circulatory physiology 20030701