292605-14-2 | Sb-3ct

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$11.00	$8.00
5mg	95%	in stock	$20.00	$14.00
10mg	95%	in stock	$31.00	$22.00
100mg	95%	in stock	$285.00	$199.00
250mg	95%	in stock	$443.00	$310.00
1g	95%	in stock	$1,224.00	$857.00

Description

• Catalog Number: AB36982
• Chemical Name: Sb-3ct
• CAS Number: 292605-14-2
• Molecular Formula: C15H14O3S2
• Molecular Weight: 306.39986000000005
• MDL Number: MFCD09836266
• SMILES: O=S(=O)(c1ccc(cc1)Oc1ccccc1)CC1SC1

Computed Properties

• Complexity: 401
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Undefined Atom Stereocenter Count: 1
• XLogP3: 3.2

Literature

• Arsenic Attenuates Heparin-Binding EGF-Like Growth Factor/EGFR Signaling That Promotes Matrix Metalloprotease 9-Dependent Astrocyte Damage in the Developing Rat Brain.

  Toxicological sciences : an official journal of the Society of Toxicology 20180401

• Mercury exposure induces cytoskeleton disruption and loss of renal function through epigenetic modulation of MMP9 expression.

  Toxicology 20170701

• Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study.

  Stroke 20120901

• Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.

  American journal of physiology. Endocrinology and metabolism 20120701

• Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells.

  Biology of reproduction 20120501

• Selective water-soluble gelatinase inhibitor prodrugs.

  Journal of medicinal chemistry 20111013

• Matrix metalloproteinase-9 controls proliferation of NG2+ progenitor cells immediately after spinal cord injury.

  Experimental neurology 20111001

• Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives.

  European journal of oral sciences 20101001

• Urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9.

  Neurochemical research 20100701

• ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9.

  Archives of pharmacal research 20100201

• Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT.

  The journal of physical chemistry. B 20100121

• Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.

  Chemical biology & drug design 20091201

• Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.

  Chemical biology & drug design 20091201

• Inhibition of enzymatic degradation of adhesive-dentin interfaces.

  Journal of dental research 20091201

• Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue.

  Biochemistry 20091020

• DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2.

  Organic letters 20090618

• TNF alpha-mediated disruption of spermatogenesis in response to Sertoli cell injury in rodents is partially regulated by MMP2.

  Biology of reproduction 20090301

• Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.

  Bioorganic & medicinal chemistry 20081001

• Conformational analyses of thiirane-based gelatinase inhibitors.

  Bioorganic & medicinal chemistry letters 20080515

• Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor.

  Chemical biology & drug design 20080301

• Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080102

• Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.

  Journal of molecular biology 20070824

• Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents.

  Brain research 20070216

• Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.

  Organic letters 20050929

• Matrix metalloproteinases are required for retinal ganglion cell axon guidance at select decision points.

  Development (Cambridge, England) 20050801

• A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent.

  The Journal of organic chemistry 20040514