29342-05-0 | Ciclopirox

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$15.00	$10.00
50mg	95%	in stock	$18.00	$12.00
1g	95%	in stock	$26.00	$18.00
5g	95%	in stock	$57.00	$40.00
25g	95%	in stock	$163.00	$114.00
100g	95%	in stock	$387.00	$271.00
500g	95%	in stock	$1,505.00	$1,054.00

Description

• Catalog Number: AB37303
• Chemical Name: Ciclopirox
• CAS Number: 29342-05-0
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.2688800000001
• MDL Number: MFCD00599441
• SMILES: Cc1cc(C2CCCCC2)n(c(=O)c1)O

Computed Properties

• Complexity: 325
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2

Literature

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• A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.

  PloS one 20120101

• Comparative clinical evaluation of efficacy and safety of a formulation containing ciclopirox 8% in the form of a therapeutic nail lacquer in two different posologies for the treatment of onychomycosis of the toes.

  Anais brasileiros de dermatologia 20120101

• Animal model of dermatophytosis.

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  Mycoses 20111101

• Standardization of hyphal growth inhibition rate as a means of evaluating Microsporum spp. in vitro susceptibility to terbinafine, griseofulvin, and ciclopiroxolamine.

  Mycopathologia 20111001

• Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.

  American journal of physiology. Cell physiology 20111001

• Tinea capitis in an adult patient under treatment with trastuzumab.

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  Leukemia research 20110801

• Characterization of the antimicrobial susceptibility of fungi responsible for onychomycosis in Spain.

  Medical mycology 20110701

• Validation of bovine hoof slices as a model for infected human toenails: in vitro ciclopirox transungual permeation.

  The British journal of dermatology 20110701

• Topical antifungal agents for seborrheic dermatitis: systematic review and meta-analysis.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20110601

• The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway.

  Oncogene 20110505

• Multipotent adult germline stem cells and embryonic stem cells functional proteomics revealed an important role of eukaryotic initiation factor 5A (Eif5a) in stem cell differentiation.

  Journal of proteome research 20110401

• The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy.

  Journal of clinical pharmacy and therapeutics 20110401

• Determination of ciclopirox olamine in pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection.

  Electrophoresis 20110401

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• Increased in vivo efficacy of lenalidomide by addition of piroctone olamine.

  In vivo (Athens, Greece) 20110101

• Antifungal testing and high-throughput screening of compound library against Geomyces destructans, the etiologic agent of geomycosis (WNS) in bats.

  PloS one 20110101

• In vitro antifungal susceptibility testing of Scopulariopsis brevicaulis strains using agar diffusion method.

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• Antifungal susceptibility of dermatophytes isolated from patients with chronic renal failure.

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• Onychomycosis: Diagnosis and management.

  Indian journal of dermatology, venereology and leprology 20110101

• Targeting the Wnt/beta-catenin pathway with the antifungal agent ciclopirox olamine in a murine myeloma model.

  In vivo (Athens, Greece) 20110101

• Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes.

  Molecular neurodegeneration 20110101

• FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.

  PloS one 20110101

• Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing.

  PloS one 20110101

• Safety and efficacy of tinea pedis and onychomycosis treatment in people with diabetes: a systematic review.

  Journal of foot and ankle research 20110101

• Farnesol, a fungal quorum-sensing molecule triggers Candida albicans morphological changes by downregulating the expression of different secreted aspartyl proteinase genes.

  The open microbiology journal 20110101

• Comparative evaluation of effectivity and safety of topical amorolfine and clotrimazole in the treatment of tinea corporis.

  Indian journal of dermatology 20110101

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

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• The antitumor activity of the fungicide ciclopirox.

  International journal of cancer 20101115

• Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent.

  Drugs 20101112

• Widespread erosive tinea corporis by Arthroderma benhamiae in a renal transplant recipient: case report.

  Mycoses 20101101

• First case of Trichophyton soudanense isolated in Tunisia.

  Mycopathologia 20101101

• Ciclopirox olamine: an antifungal alternative against cryptococcosis.

  Letters in applied microbiology 20101101

• [Fungal diseases of vulva and vagina caused by Candida species].

  Medizinische Monatsschrift fur Pharmazeuten 20100901

• Etoposide Reduces Peroxynitrite-Induced Cytotoxicity via Direct Scavenging Effect.

  Experimental neurobiology 20100901

• Studies on nonionic surfactant bilayer vesicles of ciclopirox olamine.

  Drug development and industrial pharmacy 20100801

• Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability.

  PLoS neglected tropical diseases 20100701

• Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity.

  Experimental physiology 20100601

• Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents.

  The Journal of pharmacy and pharmacology 20100601

• Antifungal activity, experimental infections and nail permeation of an innovative ciclopirox nail lacquer based on a water-soluble biopolymer.

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• [Melanonychia: The purpose of a case of ungual mycotization mimicking melanoma].

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  The British journal of dermatology 20100201

• Ciclopirox nail lacquer for the treatment of onychomycosis: an open non-comparative study.

  The Journal of dermatology 20100201

• Trace determination of pharmaceuticals and other wastewater-derived micropollutants by solid phase extraction and gas chromatography/mass spectrometry.

  Journal of chromatography. A 20100122

• A direct LC/MS/MS method for the determination of ciclopirox penetration across human nail plate in in vitro penetration studies.

  Journal of pharmaceutical and biomedical analysis 20100105

• Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine).

  BMC genomics 20100101

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  Indian journal of dermatology 20100101

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  Dermatology research and practice 20100101

• A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children.

  Pediatric dermatology 20100101

• Upregulation of a novel eukaryotic translation initiation factor 5A (eIF5A) in dengue 2 virus-infected mosquito cells.

  Virology journal 20100101

• Role of Wnt canonical pathway in hematological malignancies.

  Journal of hematology & oncology 20100101

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  BMC systems biology 20100101

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  Retrovirology 20100101

• Randomized study comparing the efficacy and tolerance of a lipohydroxy acid shampoo to a ciclopiroxolamine shampoo in the treatment of scalp seborrheic dermatitis.

  Journal of cosmetic dermatology 20091201

• Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection.

  Medical mycology 20091101

• The human urocortin 2 gene is regulated by hypoxia: identification of a hypoxia-responsive element in the 3'-flanking region.

  The Biochemical journal 20091023

• Iontophoretically enhanced ciclopirox delivery into and across human nail plate.

  Journal of pharmaceutical sciences 20091001

• Onychomycosis and diabetes.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20091001

• Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

  Blood 20091001

• By the way, doctor. Penlac didn't work to cure my toenail fungus. I took an oral medication, terbinafine, and saw some improvement, but my insurance company won't approve more than a few months of treatment. It's frustrating to finally have a solution and then be cut off.

  Harvard health letter 20091001

• Hypoxia inducible factor-1 improves the actions of positive inotropic agents in stunned cardiac myocytes.

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• Bullous ulcerating tinea.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20090701

• An innovative water-soluble biopolymer improves efficacy of ciclopirox nail lacquer in the management of onychomycosis.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20090701

• The use of oral terbinafine or topical ciclopirox for lichen planus.

  Cutis 20090701

• Clinical practice. Fungal nail disease.

  The New England journal of medicine 20090514

• Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells.

  Neurotoxicity research 20090501

• The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease.

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  Cases journal 20090101

• Nail infection by Aspergillus ochraceopetaliformis.

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• Iron chelation and the ventilatory response to hypoxia.

  Advances in experimental medicine and biology 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.

  Retrovirology 20090101

• Evaluation of a nonsteroidal topical cream in a guinea pig model of Malassezia furfur infection.

  Clinics in dermatology 20090101

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• Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox.

  Planta medica 20081001

• Ototoxic effect of topical ciclopirox as an antimycotic preparation.

  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20081001

• Antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole.

  Cutis 20081001

• Are placebo-controlled trials of creams for athlete's foot still justified?

  The British journal of dermatology 20080901

• Fast and simple method for assay of ciclopirox olamine by micellar electrokinetic capillary chromatography.

  Journal of pharmaceutical and biomedical analysis 20080805

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  The British journal of dermatology 20080201

• Ciclopirox olamine directly scavenges hydroxyl radical.

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  Acta dermato-venereologica 20080101

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• Effects of VEGF on the blood-brain barrier disruption caused by hyperosmolarity.

  Pharmacology 20080101

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  Indian journal of dermatology 20080101

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  Indian journal of pharmaceutical sciences 20080101

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  Medical mycology 20071101

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  Journal of pharmaceutical sciences 20071001

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  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20071001

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• Trichophytic Majocchi granuloma mimicking Kaposi sarcoma.

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20070701

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  FEMS yeast research 20070501

• Inhibitory or scavenging action of ketoconazole and ciclopiroxolamine against reactive oxygen species released by primed inflammatory cells.

  The British journal of dermatology 20070401

• Antifungal acylcyclopentenediones from fruiting bodies of Hygrophorus chrysodon.

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  Drugs & aging 20070101

• Ciclopirox 8% nail lacquer topical solution for the treatment of onychomycosis in patients with diabetes: a multicenter, open-label study.

  Journal of the American Podiatric Medical Association 20070101

• Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis.

  The Journal of dermatological treatment 20070101

• An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis.

  Indian journal of dermatology, venereology and leprology 20070101

• Malassezia furfur onychomycosis in an immunosuppressed liver transplant recipient.

  Indian journal of dermatology, venereology and leprology 20070101

• Increased endogenous nitric oxide release by iron chelation and purinergic activation in the rat carotid body.

  The open biochemistry journal 20070101

• In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains.

  Mycopathologia 20061201

• Majocchi's granuloma after kidney transplantation.

  Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20061201

• [Bilateral proximal cellulitis and onychomycosis in both big toes due to Fusarium solani].

  Revista iberoamericana de micologia 20061201

• Spectrofluorimetric determination of ciclopirox olamine via ternary complex with Tb(III) and EDTA.

  Acta pharmaceutica (Zagreb, Croatia) 20061201

• Perniosis-like tinea corporis caused by Trichophyton verrucosum in cold-exposed individuals.

  Mycoses 20061101

• Athlete's foot.

  BMJ clinical evidence 20061101

• Cost-effectiveness of diagnostic tests for toenail onychomycosis: a repeated-measure, single-blinded, cross-sectional evaluation of 7 diagnostic tests.

  Journal of the American Academy of Dermatology 20061001

• Anti-inflammatory and anti-itch activity of sertaconazole nitrate.

  Archives of dermatological research 20060901

• Piperidones with activity against Plasmodium falciparum.

  Parasitology research 20060801

• Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

  Journal of medicinal chemistry 20060727

• Dystrophic onychomycosis due to Microsporum gypseum.

  Mycoses 20060701

• Contact dermatitis due to ciclopiroxolamine.

  Mycoses 20060701

• Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails.

  Die Pharmazie 20060701

• Therapeutic potential of iron chelators in diseases associated with iron mismanagement.

  The Journal of pharmacy and pharmacology 20060501

• Effects of antifungal drugs on proliferation signals in Candida albicans.

  Biological & pharmaceutical bulletin 20060501

• Antimycotic influence of beta-cyclodextrin complexes--in vitro measurements using laser nephelometry in microtiter plates.

  International journal of pharmaceutics 20060327

• Congenital candidal onychomycoses: effective cure with ciclopirox olamine 8% nail lacquer.

  The British journal of dermatology 20060301

• What defines the quality of patient care in tinea pedis?

  Journal of the European Academy of Dermatology and Venereology : JEADV 20060201

• Evaluating costs for onychomycosis treatments: a practitioner's perspective.

  Journal of the American Podiatric Medical Association 20060101

• Ciclopirox 1% shampoo for the treatment of seborrheic dermatitis.

  International journal of dermatology 20060101

• Treatment of head and neck dermatitis with ciclopiroxolamine cream--results of a double-blind, placebo-controlled study.

  Skin pharmacology and physiology 20060101

• [Modern management of dandruff].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060101

• Rapid treatment of tinea nigra palmaris with ciclopirox olamine gel, 0.77%.

  Skinmed 20060101

• Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

  Molecular neurodegeneration 20060101

• Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp seborrheic dermatitis treatment.

  European journal of dermatology : EJD 20060101

• A-Detail fact sheet (Canada). Ciclopirox 8% nail lacquer (Penlac).

  Skin therapy letter 20051201

• Ciclopirox nail lacquer 8% for the treatment of onychomycosis: a Canadian perspective.

  Skin therapy letter 20050901

• In vitro susceptibility of 15 strains of zygomycetes to nine antifungal agents as determined by the NCCLS M38-A microdilution method.

  Mycoses 20050701

• Evaluation of the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis (dermatophytosis complex) in a randomized, double-blind, placebo-controlled trial.

  International journal of dermatology 20050701

• Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

  Blood 20050615

• Ciclopirox protects mitochondria from hydrogen peroxide toxicity.

  British journal of pharmacology 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Can the use of a topical antifungal nail lacquer reduce risk for diabetic foot ulceration? Results from a randomised controlled pilot study.

  International wound journal 20050601

• Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans.

  The Journal of antimicrobial chemotherapy 20050501

• Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans.

  The Journal of antimicrobial chemotherapy 20050501

• Pharmacotherapy of onychomycosis.

  Expert opinion on pharmacotherapy 20050401

• Trichophyton rubrum isolated from aids and human immunodeficiency virus-infected patients in São Paulo, Brazil: antifungal susceptibility and extracellular enzyme production.

  Chemotherapy 20050301

• The safety and efficacy of ciclopirox olamine for the treatment of seborrheic dermatitis.

  Expert opinion on drug safety 20050301

• Physicochemical studies on Ciclopirox olamine complexes with divalent metal ions.

  International journal of pharmaceutics 20050131

• Topical antifungal drugs for the treatment of onychomycosis: an overview of current strategies for monotherapy and combination therapy.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20050101

• Treatment and prophylaxis of seborrheic dermatitis of the scalp with antipityrosporal 1% ciclopirox shampoo.

  Archives of dermatology 20050101

• Pharmacoeconomic analysis of sequential treatment pathways in the treatment of onychomycosis.

  Managed care interface 20050101

• A multicenter, open-label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans.

  Journal of drugs in dermatology : JDD 20050101

• In vitro transungual permeation of ciclopirox from a hydroxypropyl chitosan-based, water-soluble nail lacquer.

  Drug development and industrial pharmacy 20050101

• Ciclopirox topical solution, 8% combined with oral terbinafine to treat onychomycosis: a randomized, evaluator-blinded study.

  Journal of drugs in dermatology : JDD 20050101

• Treatment costs of three nail lacquers used in onychomycosis.

  The Journal of dermatological treatment 20050101

• Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis.

  The Journal of dermatological treatment 20050101

• Cutaneous adiaspiromycosis: a distinct dermatologic entity associated with Chrysosporium species.

  Journal of the American Academy of Dermatology 20041101

• Ciclopirox delivery into the human nail plate.

  Journal of pharmaceutical sciences 20041001

• Management of onychomycosis with topicals.

  Clinics in podiatric medicine and surgery 20041001

• Cell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage.

  Journal of cell science 20041001

• [Chronic favus caused by infection with Trichophyton schönleinii].

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20041001

• Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva.

  Gynecologic oncology 20040701

• Ciclopirox: a broad-spectrum antifungal with antibacterial and anti-inflammatory properties.

  International journal of dermatology 20040701

• Efficacy of different concentrations of ciclopirox shampoo for the treatment of seborrheic dermatitis of the scalp: results of a randomized, double-blind, vehicle-controlled trial.

  International journal of dermatology 20040701

• Rationale of frequency of use of ciclopirox 1% shampoo in the treatment of seborrheic dermatitis: results of a double-blind, placebo-controlled study comparing the efficacy of once, twice, and three times weekly usage.

  International journal of dermatology 20040701

• Safety and efficacy of ciclopirox 1% shampoo for the treatment of seborrheic dermatitis of the scalp in the US population: results of a double-blind, vehicle-controlled trial.

  International journal of dermatology 20040701

• Management of onychomycosis: examining the role of monotherapy and dual, triple, or quadruple therapies.

  Cutis 20040701

• Onychomycosis: review of recurrence rates, poor prognostic factors, and strategies to prevent disease recurrence.

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• Activation of HIF-1alpha mRNA by hypoxia and iron chelator in isolated rat carotid body.

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