-
Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies.
Archives of toxicology 20180713
-
Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Chemico-biological interactions 20180601
-
Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors.
Toxicological sciences : an official journal of the Society of Toxicology 20180401
-
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.
Archives of toxicology 20180401
-
Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells.
Veterinary immunology and immunopathology 20180301
-
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Frontiers in immunology 20180101
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Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis.
Toxicological sciences : an official journal of the Society of Toxicology 20170901
-
B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.
Toxicology 20170701
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Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.
Archives of toxicology 20170601
-
Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics.
Molecular pharmacology 20170401
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Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS.
The Journal of biological chemistry 20161125
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Activation of the Constitutive Androstane Receptor by Monophthalates.
Chemical research in toxicology 20161017
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Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
The Journal of biological chemistry 20160520
-
Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway.
Chemico-biological interactions 20160425
-
Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.
Toxicology and applied pharmacology 20160401
-
Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.
ACS medicinal chemistry letters 20150813
-
Activation of liver X receptors inhibits cadmium-induced apoptosis of human renal proximal tubular cells.
Toxicology letters 20150805
-
Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.
Chemical research in toxicology 20150615
-
Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.
Toxicology 20150302
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Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux.
Chemical research in toxicology 20141020
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Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.
Toxicological sciences : an official journal of the Society of Toxicology 20140801
-
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Archives of pharmacal research 20140101
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Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.
Toxicology in vitro : an international journal published in association with BIBRA 20131001
-
Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.
Toxicology and applied pharmacology 20130815
-
Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.
Biochemical pharmacology 20130801
-
Resveratrol suppresses T0901317-induced hepatic fat accumulation in mice.
The AAPS journal 20130701
-
Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.
Journal of hepatology 20130501
-
Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells.
Toxicology and applied pharmacology 20130415
-
Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein.
The Journal of biological chemistry 20130322
-
A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.
Biochimie 20130301
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Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo.
Translational research : the journal of laboratory and clinical medicine 20130201
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TO901317, a potent LXR agonist, is an inverse agonist of CAR.
The Journal of toxicological sciences 20130101
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Activation of liver X receptor induces macrophage interleukin-5 expression.
The Journal of biological chemistry 20121221
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A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.
The Journal of biological chemistry 20121102
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Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice.
The Journal of steroid biochemistry and molecular biology 20121101
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Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 20121101
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Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages.
The Journal of nutritional biochemistry 20121001
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Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.
Molecular pharmacology 20121001
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Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.
Journal of medicinal chemistry 20120913
-
Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway.
The Journal of nutritional biochemistry 20120901
-
Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner.
Antiviral research 20120901
-
Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
Arteriosclerosis, thrombosis, and vascular biology 20120901
-
Liver X receptor agonist alleviated high glucose-induced endothelial progenitor cell dysfunction via inhibition of reactive oxygen species and activation of AMP-activated protein kinase.
Microcirculation (New York, N.Y. : 1994) 20120801
-
Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ.
Toxicology letters 20120720
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LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.
Anticancer research 20120701
-
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.
Bioorganic & medicinal chemistry letters 20120615
-
Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines.
Diabetologia 20120601
-
Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol.
Atherosclerosis 20120601
-
Lipopolysaccharide represses the expression of ATP-binding cassette transporter G1 and scavenger receptor class B, type I in murine macrophages.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120501
-
Liver X receptor α is involved in the transcriptional regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.
Diabetes 20120501
-
Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.
The Journal of clinical investigation 20120501
-
ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells.
Biochemical and biophysical research communications 20120427
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HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.
Journal of lipid research 20120401
-
Discovery of a new binding mode for a series of liver X receptor agonists.
Bioorganic & medicinal chemistry letters 20120401
-
Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.
Toxicology and applied pharmacology 20120315
-
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Brain pathology (Zurich, Switzerland) 20120301
-
Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.
Biology of reproduction 20120301
-
Effect of simvastatin on the expression and regulation mechanism of apolipoprotein M.
International journal of molecular medicine 20120301
-
Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.
American journal of physiology. Renal physiology 20120301
-
Activation of liver X receptors attenuates endotoxin-induced liver injury in mice with nonalcoholic fatty liver disease.
Digestive diseases and sciences 20120201
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Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line.
Biochemical pharmacology 20120115
-
Liver X receptors regulate cholesterol homeostasis in oligodendrocytes.
Journal of neuroscience research 20120101
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Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux.
Lipids in health and disease 20120101
-
Myelin-derived lipids modulate macrophage activity by liver X receptor activation.
PloS one 20120101
-
Synthetic LXR agonist inhibits the development of atherosclerosis in New Zealand White rabbits.
Biochimica et biophysica acta 20111201
-
Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats.
International immunopharmacology 20111201
-
Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.
Lipids 20111101
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Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Gα i/o inhibition.
Molecular pharmacology 20111101
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T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected].
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20111101
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Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.
Antioxidants & redox signaling 20111015
-
Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels.
Neurochemical research 20111001
-
Modified low density lipoproteins decrease the activity and expression of lysosomal acid lipase in human endothelial and smooth muscle cells.
Cell biochemistry and biophysics 20110901
-
n-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice.
Biochimica et biophysica acta 20110901
-
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
Environmental health perspectives 20110801
-
PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
The Biochemical journal 20110801
-
Liver X receptor activation restores memory in aged AD mice without reducing amyloid.
Neurobiology of aging 20110701
-
The effect of diet on the response of low-density lipoprotein receptor knockout mice to the liver X receptor agonist T1317.
Journal of cardiovascular pharmacology 20110701
-
LXR as a novel antithrombotic target.
Blood 20110526
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Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110511
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Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.
Journal of immunology (Baltimore, Md. : 1950) 20110415
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Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.
Shock (Augusta, Ga.) 20110401
-
Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.
Toxicological sciences : an official journal of the Society of Toxicology 20110401
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Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.
Antioxidants & redox signaling 20110301
-
Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice.
Gastroenterology 20110301
-
Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death.
Endocrinology 20110301
-
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Journal of medicinal chemistry 20110210
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Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110201
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Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.
Atherosclerosis 20110201
-
Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.
Placenta 20110201
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Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs.
Journal of cellular biochemistry 20110201
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Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.
Atherosclerosis 20110101
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The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.
BMC biochemistry 20110101
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Human cytochrome P450 1A1 is a novel target gene of liver X receptor α.
Drug metabolism and pharmacokinetics 20110101
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Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription.
International journal of biological sciences 20110101
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Palmitic acid-induced apoptosis in pancreatic β-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate.
In vivo (Athens, Greece) 20110101
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LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL.
Lipids in health and disease 20110101
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A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.
BMC systems biology 20110101
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Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.
PloS one 20110101
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TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells.
Lipids in health and disease 20110101
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Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity.
Journal of lipid research 20101201
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hCG-induced down-regulation of PPARγ and liver X receptors promotes periovulatory progesterone synthesis by macaque granulosa cells.
Endocrinology 20101201
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Regulation of ABCG1 expression in human keratinocytes and murine epidermis.
Journal of lipid research 20101101
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Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo.
European journal of heart failure 20101001
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The liver X receptor (LXR) and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells: a reason for alterations in preeclampsia?
Placenta 20101001
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Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
Arteriosclerosis, thrombosis, and vascular biology 20101001
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LXRalpha regulates human CETP expression in vitro and in transgenic mice.
Atherosclerosis 20100901
-
Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines.
Anticancer research 20100901
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Activation of LXRα induces lipogenesis in HaCaT cells.
Archives of pharmacal research 20100901
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An agonist of liver X receptor slows valvular disease in a hypercholesterolemia mouse model.
The Journal of heart valve disease 20100901
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Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100801
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Metabolic switching of human myotubes is improved by n-3 fatty acids.
Journal of lipid research 20100801
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Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1.
Molecular pharmacology 20100801
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Recent progress in liver X receptor-selective modulators.
Current opinion in drug discovery & development 20100701
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The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
The Journal of biological chemistry 20100625
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Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.
Cardiovascular research 20100601
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Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
Oncogene 20100506
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Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Bioorganic & medicinal chemistry letters 20100501
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Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Journal of medicinal chemistry 20100422
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Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.
Journal of medicinal chemistry 20100422
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FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
Circulation research 20100305
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Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.
Analytical and bioanalytical chemistry 20100301
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Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
The Journal of biological chemistry 20100219
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Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis.
Free radical biology & medicine 20100215
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Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat.
The Journal of endocrinology 20100201
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Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma.
Journal of neurochemistry 20100201
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Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury.
Journal of leukocyte biology 20100201
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Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.
Bioorganic & medicinal chemistry letters 20100115
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3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.
Bioorganic & medicinal chemistry letters 20100115
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The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands.
Molecular pharmacology 20100101
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Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein.
Gynecologic oncology 20100101
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4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.
Bioorganic & medicinal chemistry letters 20100101
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Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation.
Respiratory research 20100101
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Liver X receptor agonist methyl-3β-hydroxy-5α,6α-epoxycholanate attenuates atherosclerosis in apolipoprotein E knockout mice without increasing plasma triglyceride.
Pharmacology 20100101
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Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.
Biochemistry 20091222
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Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling.
Neuroscience 20091201
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4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.
Bioorganic & medicinal chemistry 20091201
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LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Atherosclerosis 20091101
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Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice.
American journal of physiology. Endocrinology and metabolism 20091101
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Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver.
Biochimica et biophysica acta 20091101
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Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells.
Free radical research 20091001
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An induction in hepatic HDL secretion associated with reduced ATPase expression.
The American journal of pathology 20091001
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Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet.
Atherosclerosis 20090901
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On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Atherosclerosis 20090801
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LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins.
American journal of physiology. Gastrointestinal and liver physiology 20090801
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Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.
American journal of physiology. Endocrinology and metabolism 20090801
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Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.
The Journal of biological chemistry 20090717
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Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice.
Journal of lipid research 20090701
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Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Endocrinology 20090701
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eNOS mediates TO90317 treatment-induced angiogenesis and functional outcome after stroke in mice.
Stroke 20090701
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Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells.
Molecular cancer therapeutics 20090701
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Compound reduces viral cholesterol and inhibits HIV-1.
AIDS patient care and STDs 20090701
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Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.
Endocrinology 20090601
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Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.
Bioorganic & medicinal chemistry 20090515
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25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.
Journal of neurochemistry 20090501
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Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists.
European journal of pharmacology 20090401
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Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.
Bioorganic & medicinal chemistry letters 20090315
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LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms.
Journal of lipid research 20090201
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Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c.
Biochimica et biophysica acta 20090201
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Suppression of beta-catenin signaling by liver X receptor ligands.
Biochemical pharmacology 20090115
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Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.
Molecular pharmaceutics 20090101
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Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays.
Methods in molecular biology (Clifton, N.J.) 20090101
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Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance.
Cardiovascular diabetology 20090101
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Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome.
Human molecular genetics 20081201
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Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages.
Arteriosclerosis, thrombosis, and vascular biology 20081201
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Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism.
American journal of physiology. Endocrinology and metabolism 20081201
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LXR-agonists regulate ApoM expression differentially in liver and intestine.
Current pharmaceutical biotechnology 20081201
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Beneficial effect of 3,4,5,6-tetrahydroxyxanthone on dyslipidemia in apolipoprotein E-deficient mice.
Canadian journal of physiology and pharmacology 20081201
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Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Journal of medicinal chemistry 20081127
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Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.
Neuroreport 20081119
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Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20081105
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Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice.
The Journal of pharmacology and experimental therapeutics 20081101
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Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.
Endocrinology 20081001
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Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Journal of medicinal chemistry 20080925
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Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity.
American journal of physiology. Endocrinology and metabolism 20080801
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PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine.
Biochemical and biophysical research communications 20080711
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Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: paracrine interaction with myocytes.
The Journal of clinical endocrinology and metabolism 20080701
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Liver X receptor agonist downregulates hepatic apoM expression in vivo and in vitro.
Biochemical and biophysical research communications 20080620
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Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.
Gastroenterology 20080601
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Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus.
Circulation 20080527
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LXRalpha enhances lipid synthesis in SZ95 sebocytes.
The Journal of investigative dermatology 20080501
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The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential.
Journal of lipid research 20080501
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Ligand specificity and evolution of liver X receptors.
The Journal of steroid biochemistry and molecular biology 20080501
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The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick type C1 in apoE-/- mice.
Journal of cardiovascular pharmacology 20080501
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Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expression.
Science in China. Series C, Life sciences 20080501
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Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Bioorganic & medicinal chemistry 20080415
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Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.
The Journal of biological chemistry 20080411
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Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators.
Journal of medicinal chemistry 20080410
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Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
American journal of physiology. Gastrointestinal and liver physiology 20080401
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Effects of the synthetic liver X receptor agonist T0901317 on the growth hormone and thyroid hormone axes in male rats.
Endocrine 20080401
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[Activation of liver X receptor regulates fatty acid synthase expression in diabetic liver].
Zhonghua yi xue za zhi 20080325
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Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
Journal of immunology (Baltimore, Md. : 1950) 20080301
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Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive amine oxidase gene expression and activity in apolipoprotein E knockout mice.
Acta biochimica et biophysica Sinica 20080301
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LXR agonist increases the lymph HDL transport in rats by promoting reciprocally intestinal ABCA1 and apo A-I mRNA levels.
Lipids 20080201
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OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.
The Journal of biological chemistry 20080104
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The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation.
Atherosclerosis 20080101
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Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Bioorganic & medicinal chemistry letters 20080101
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Liver X receptors (LXR) as therapeutic targets in dyslipidemia.
Cardiovascular therapeutics 20080101
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Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.
Journal of lipid research 20071201
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Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists.
Biochemical pharmacology 20071115
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Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL.
Journal of lipid research 20071101
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SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
Molecular cell 20071012
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Regulation of 17beta-hydroxysteroid dehydrogenase type 2, type 4 and type 5 by calcitriol, LXR agonist and 5alpha-dihydrotestosterone in human prostate cancer cells.
The Journal of steroid biochemistry and molecular biology 20071001
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Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.
Bioorganic & medicinal chemistry letters 20071001
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N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
Journal of medicinal chemistry 20070823
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2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.
Bioorganic & medicinal chemistry letters 20070815
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Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.
Molecular and cellular biochemistry 20070801
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Effect of T0901317 on hepatic proinflammatory gene expression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Inflammation 20070801
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Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.
The Journal of biological chemistry 20070720
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A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c.
The Journal of biological chemistry 20070622
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Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.
Bioorganic & medicinal chemistry letters 20070615
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Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway.
Biochemical and biophysical research communications 20070608
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The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells.
Biochemical and biophysical research communications 20070601
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Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.
Molecular human reproduction 20070601
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Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.
Blood 20070515
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T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR.
FEBS letters 20070501
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Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.
Endocrinology 20070401
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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.
Molecular and cellular neurosciences 20070401
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Immunomodulatory properties of increased levels of liver X receptor beta in peripheral blood mononuclear cells from multiple sclerosis patients.
Experimental neurology 20070401
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Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
Bioorganic & medicinal chemistry 20070301
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PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Journal of lipid research 20070201
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24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression.
Journal of neurochemistry 20070201
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Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.
Hepatology (Baltimore, Md.) 20070201
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Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.
Oncogene 20070111
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The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.
The Journal of biological chemistry 20070105
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Liver X receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells.
Biochemistry 20061219
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22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes.
Biochimica et biophysica acta 20061201
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Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.
Endocrinology 20061101
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The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.
Biochemical and biophysical research communications 20061020
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Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
Journal of medicinal chemistry 20061019
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Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor.
The Biochemical journal 20061015
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Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.
Bioorganic & medicinal chemistry letters 20061001
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Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Journal of lipid research 20060901
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The chicken ovalbumin upstream promoter-transcription factors modulate genes and pathways involved in skeletal muscle cell metabolism.
The Journal of biological chemistry 20060825
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Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents.
Bioorganic & medicinal chemistry letters 20060815
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Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.
Endocrinology 20060801
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Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha.
Toxicological sciences : an official journal of the Society of Toxicology 20060801
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The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.
Journal of neurochemistry 20060801
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The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.
Hepatology (Baltimore, Md.) 20060801
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Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.
Shock (Augusta, Ga.) 20060801
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Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites.
The EMBO journal 20060712
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Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells.
Cell research 20060701
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Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist.
Cancer research 20060701
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[Liver X receptors mediate cholesterol efflux in mouse glomerular mesangial cells].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060618
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ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid-bile acid conjugates (FABACs).
The Biochemical journal 20060615
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Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study.
Journal of lipid research 20060601
-
Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule.
American journal of physiology. Renal physiology 20060501
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PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.
Journal of lipid research 20060501
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Discovery and optimization of a novel series of liver X receptor-alpha agonists.
Bioorganic & medicinal chemistry letters 20060315
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Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.
The Journal of biological chemistry 20060310
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Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor.
Neuroreport 20060206
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Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells.
The international journal of biochemistry & cell biology 20060101
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Non-steroidal LXR agonists; an emerging therapeutic strategy for the treatment of atherosclerosis.
Recent patents on cardiovascular drug discovery 20060101
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Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line.
Placenta 20051101
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The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver.
Journal of lipid research 20051001
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Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.
International journal of molecular medicine 20051001
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Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Journal of medicinal chemistry 20050825
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Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.
Cell metabolism 20050501
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Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors.
Atherosclerosis 20050401
-
Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway.
Diabetes 20050401
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Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells.
The Journal of biological chemistry 20050204
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Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists.
Arteriosclerosis, thrombosis, and vascular biology 20050101
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Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
Circulation research 20041210
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LXR activation and cholesterol efflux from a lipoprotein depot in vivo.
Biochimica et biophysica acta 20041108
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Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.
The Journal of biological chemistry 20041029
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Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Journal of molecular endocrinology 20041001
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Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver.
The Journal of biological chemistry 20040702
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Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.
The Journal of pharmacology and experimental therapeutics 20040601
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A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.
Journal of neurochemistry 20040201
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Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.
Gastroenterology 20040101
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CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 20040101
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T0901317 is a dual LXR/FXR agonist.
Molecular genetics and metabolism 20040101
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Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.
Journal of molecular biology 20031212
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The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse.
Journal of lipid research 20031101
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Molecular determinants of LXRalpha agonism.
Journal of molecular graphics & modelling 20031101
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Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
The Journal of biological chemistry 20030919
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Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.
The EMBO journal 20030915
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X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
The Journal of biological chemistry 20030718
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Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Molecular endocrinology (Baltimore, Md.) 20030701
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Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Molecular endocrinology (Baltimore, Md.) 20030701
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Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor.
The Journal of biological chemistry 20030613
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Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.
Journal of hepatology 20030601
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Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.
The Journal of biological chemistry 20030502
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Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.
Molecular endocrinology (Baltimore, Md.) 20030301
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Pharmacological evidence for a role of liver X receptors in atheroprotection.
FEBS letters 20030211
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T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.
FEBS letters 20030211
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On the role of liver X receptors in lipid accumulation in adipocytes.
Molecular endocrinology (Baltimore, Md.) 20030201
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A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
The Journal of biological chemistry 20030124
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Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.
The Journal of biological chemistry 20030110
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Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.
The Biochemical journal 20021215
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Phospholipid transfer protein is regulated by liver X receptors in vivo.
The Journal of biological chemistry 20021018
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Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles.
The Journal of biological chemistry 20020913
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Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.
The Journal of biological chemistry 20020913
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LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.
Journal of lipid research 20020701
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Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Journal of medicinal chemistry 20020509
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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
The Journal of biological chemistry 20020315
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Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.
Molecular endocrinology (Baltimore, Md.) 20020301
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Hypolipidemic effects of selective liver X receptor alpha agonists.
Steroids 20010901
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Role of LXRs in control of lipogenesis.
Genes & development 20001115
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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
The Journal of biological chemistry 20000519
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Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary.
Molecular endocrinology (Baltimore, Md.)
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Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
Molecular endocrinology (Baltimore, Md.)