2949-92-0 | S-Methyl methanethiosulfonate

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$9.00	$6.00
5g	98%	in stock	$14.00	$10.00
25g	98%	in stock	$56.00	$39.00
100g	98%	in stock	$183.00	$128.00

Description

• Catalog Number: AB37916
• Chemical Name: S-Methyl methanethiosulfonate
• CAS Number: 2949-92-0
• Molecular Formula: C2H6O2S2
• Molecular Weight: 126.1978
• MDL Number: MFCD00007565
• SMILES: CSS(=O)(=O)C
• NSC Number: 21545

Computed Properties

• Complexity: 106
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1

Literature

• Interaction of S-methyl methanethiosulfonate with DPPC bilayer.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

• Catalytic zinc site and mechanism of the metalloenzyme PR-AMP cyclohydrolase.

  Biochemistry 20120724

• The cyclic nucleotide cGMP is involved in plant hormone signalling and alters phosphorylation of Arabidopsis thaliana root proteins.

  Journal of experimental botany 20120501

• Cloning, overexpression and characterization of Leishmania donovani triosephosphate isomerase.

  Experimental parasitology 20120401

• S-Nitrosylated proteins in pea (Pisum sativum L.) leaf peroxisomes: changes under abiotic stress.

  Journal of experimental botany 20120301

• The TM2 6' position of GABA(A) receptors mediates alcohol inhibition.

  The Journal of pharmacology and experimental therapeutics 20120201

• MS/MS library facilitated MRM quantification of native peptides prepared by denaturing ultrafiltration.

  Proteome science 20120101

• Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO.

  PloS one 20120101

• Using a spike-in experiment to evaluate analysis of LC-MS data.

  Proteome science 20120101

• EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer.

  BMC cancer 20120101

• Interrelationships between yeast ribosomal protein assembly events and transient ribosome biogenesis factors interactions in early pre-ribosomes.

  PloS one 20120101

• HDL proteome in hemodialysis patients: a quantitative nanoflow liquid chromatography-tandem mass spectrometry approach.

  PloS one 20120101

• Differential proteome profiling using iTRAQ in microalbuminuric and normoalbuminuric type 2 diabetic patients.

  Experimental diabetes research 20120101

• Quantitative proteomic (iTRAQ) analysis of 1st trimester maternal plasma samples in pregnancies at risk for preeclampsia.

  Journal of biomedicine & biotechnology 20120101

• Redox proteomics identification of oxidatively modified myocardial proteins in human heart failure: implications for protein function.

  PloS one 20120101

• Resistance of Trichoplusia ni to Bacillus thuringiensis toxin Cry1Ac is independent of alteration of the cadherin-like receptor for Cry toxins.

  PloS one 20120101

• The type III secreted protein BspR regulates the virulence genes in Bordetella bronchiseptica.

  PloS one 20120101

• Identification of cysteines involved in the effects of methanethiosulfonate reagents on human equilibrative nucleoside transporter 1.

  Molecular pharmacology 20111001

• Site-directed methyl group labeling as an NMR probe of structure and dynamics in supramolecular protein systems: applications to the proteasome and to the ClpP protease.

  Journal of the American Chemical Society 20110615

• Structural and biochemical characterization of a recombinant triosephosphate isomerase from Rhipicephalus (Boophilus) microplus.

  Insect biochemistry and molecular biology 20110601

• Network-based pipeline for analyzing MS data: an application toward liver cancer.

  Journal of proteome research 20110506

• The synaptic proteome during development and plasticity of the mouse visual cortex.

  Molecular & cellular proteomics : MCP 20110501

• Identification of multiple folding pathways of monellin using pulsed thiol labeling and mass spectrometry.

  Biochemistry 20110419

• An informatics-assisted label-free approach for personalized tissue membrane proteomics: case study on colorectal cancer.

  Molecular & cellular proteomics : MCP 20110401

• iTRAQ analysis reveals mechanisms of growth defects due to excess zinc in Arabidopsis.

  Plant physiology 20110401

• Index-ion triggered MS2 ion quantification: a novel proteomics approach for reproducible detection and quantification of targeted proteins in complex mixtures.

  Molecular & cellular proteomics : MCP 20110301

• Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation.

  Journal of proteome research 20110107

• Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E.coli.

  Microbial cell factories 20110101

• Isolation of bacterial ribosomes with monolith chromatography.

  PloS one 20110101

• High-throughput peptide quantification using mTRAQ reagent triplex.

  BMC bioinformatics 20110101

• Multi-omics approach to study the growth efficiency and amino acid metabolism in Lactococcus lactis at various specific growth rates.

  Microbial cell factories 20110101

• Proteomic analysis of the marine diatom Thalassiosira pseudonana upon exposure to benzo(a)pyrene.

  BMC genomics 20110101

• Altered protein expression in serum from endometrial hyperplasia and carcinoma patients.

  Journal of hematology & oncology 20110101

• Periostin identified as a potential biomarker of prostate cancer by iTRAQ-proteomics analysis of prostate biopsy.

  Proteome science 20110101

• Absence of ataxin-3 leads to enhanced stress response in C. elegans.

  PloS one 20110101

• NNK-Induced Lung Tumors: A Review of Animal Model.

  Journal of oncology 20110101

• Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis.

  International journal of inflammation 20110101

• Nitric oxide enhances desiccation tolerance of recalcitrant Antiaris toxicaria seeds via protein S-nitrosylation and carbonylation.

  PloS one 20110101

• Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.

  Frontiers in microbiology 20110101

• S-nitrosation of cellular proteins by NO donors in rat embryonic fibroblast 3Y1 cells: factors affecting S-nitrosation.

  Oxidative medicine and cellular longevity 20110101

• Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation: Effect of Ghrelin.

  ISRN gastroenterology 20110101

• Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy.

  Experimental diabetes research 20110101

• Effect of oxidative stress on homer scaffolding proteins.

  PloS one 20110101

• Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2.

  Proteome science 20110101

• Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage.

  Journal of proteome research 20101203

• Redox regulatory mechanism of transnitrosylation by thioredoxin.

  Molecular & cellular proteomics : MCP 20101001

• Temporal profiling of the secretome during adipogenesis in humans.

  Journal of proteome research 20101001

• Palmitoylation of human FasL modulates its cell death-inducing function.

  Cell death & disease 20101001

• Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation.

  Molecular & cellular proteomics : MCP 20100901

• Proteomic signatures in plasma during early acute renal allograft rejection.

  Molecular & cellular proteomics : MCP 20100901

• Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes.

  Molecular & cellular proteomics : MCP 20100601

• The glucocorticoid receptor: a revisited target for toxins.

  Toxins 20100601

• Adsorption behavior of ferritin and buffer components, buffer agents and salts, onto silane-coupled silicon substrate.

  Colloids and surfaces. B, Biointerfaces 20100101

• 'Hot standards' for the thermoacidophilic archaeon Sulfolobus solfataricus.

  Extremophiles : life under extreme conditions 20100101

• A proteomic approach for plasma biomarker discovery with iTRAQ labelling and OFFGEL fractionation.

  Journal of biomedicine & biotechnology 20100101

• Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ).

  Journal of biomedicine & biotechnology 20100101

• ESNOQ, proteomic quantification of endogenous S-nitrosation.

  PloS one 20100101

• Ghrelin protection against lipopolysaccharide-induced gastric mucosal cell apoptosis involves constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation.

  Mediators of inflammation 20100101

• Comparative proteomic analysis of plasma membrane proteins between human osteosarcoma and normal osteoblastic cell lines.

  BMC cancer 20100101

• Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum.

  Proteome science 20100101

• Direct regulation of striated muscle myosins by nitric oxide and endogenous nitrosothiols.

  PloS one 20100101

• GPS-SNO: computational prediction of protein S-nitrosylation sites with a modified GPS algorithm.

  PloS one 20100101

• Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides.

  Parasites & vectors 20100101

• Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels.

  PloS one 20100101

• Rapid dopaminergic modulation of the fish hypothalamic transcriptome and proteome.

  PloS one 20100101

• PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.

  PloS one 20100101

• Mechanism of Cytosolic Phospholipase A(2) Activation in Ghrelin Protection of Salivary Gland Acinar Cells against Ethanol Cytotoxicity.

  Advances in pharmacological sciences 20100101

• Suppression by Ghrelin of Porphyromonas gingivalis-Induced Constitutive Nitric Oxide Synthase S-Nitrosylation and Apoptosis in Salivary Gland Acinar Cells.

  Journal of signal transduction 20100101

• Disulfides as cyanide antidotes: evidence for a new in vivo oxidative pathway for cyanide detoxification.

  Chemical research in toxicology 20091201

• Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.

  Biochemistry 20091027

• Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans.

  PLoS pathogens 20091001

• Reactive oxygen species potentiate the P2X2 receptor activity through intracellular Cys430.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090930

• Global screening of human cord blood proteomes for biomarkers of toxic exposure and effect.

  Environmental health perspectives 20090501

• Chelator-facilitated chemical modification of IMP-1 metallo-beta-lactamase and its consequences on metal binding.

  Biochemical and biophysical research communications 20090327

• Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.

  PLoS pathogens 20090101

• Comparison of two label-free global quantitation methods, APEX and 2D gel electrophoresis, applied to the Shigella dysenteriae proteome.

  Proteome science 20090101

• Altered proteolytic events in experimental autoimmune encephalomyelitis discovered by iTRAQ shotgun proteomics analysis of spinal cord.

  Proteome science 20090101

• Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide.

  Molecular pain 20090101

• iQuantitator: a tool for protein expression inference using iTRAQ.

  BMC bioinformatics 20090101

• Role of the domain encompassing Arg304-Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298.

  The Biochemical journal 20081115

• Structural interactions between transmembrane helices 4 and 5 of subunit a and the subunit c ring of Escherichia coli ATP synthase.

  The Journal of biological chemistry 20081114

• Autoproteolytic cleavage and activation of human acid ceramidase.

  The Journal of biological chemistry 20080425

• Copper dependence of the biotin switch assay: modified assay for measuring cellular and blood nitrosated proteins.

  Free radical biology & medicine 20080401

• Species-specific inhibition of Giardia lamblia triosephosphate isomerase by localized perturbation of the homodimer.

  Molecular and biochemical parasitology 20080201

• iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease.

  PloS one 20080101

• Improved proteome coverage by using iTRAQ labelling and peptide OFFGEL fractionation.

  Proteome science 20080101

• Exploring the cooperativity of the fast folding reaction of a small protein using pulsed thiol labeling and mass spectrometry.

  The Journal of biological chemistry 20071228

• Gas-phase structure, rotational barrier, and vibrational properties of methyl methanethiosulfonate, CH3SO2SCH3: an experimental and computational study.

  The journal of physical chemistry. A 20071004

• Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage.

  Cellular signalling 20070901

• Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.

  American journal of physiology. Renal physiology 20070901

• Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity.

  The Journal of biological chemistry 20070831

• Crosstalk between the subunits of the homodimeric enzyme triosephosphate isomerase.

  Proteins 20070401

• Does s-methyl methanethiosulfonate trap the thiol-disulfide state of proteins?

  Antioxidants & redox signaling 20070401

• Growth control of the eukaryote cell: a systems biology study in yeast.

  Journal of biology 20070101

• Analysis of the Rana catesbeiana tadpole tail fin proteome and phosphoproteome during T3-induced apoptosis: identification of a novel type I keratin.

  BMC developmental biology 20070101

• Comparative proteome analysis of human epithelial ovarian cancer.

  Proteome science 20070101

• Nitric oxide destabilizes Pias3 and regulates sumoylation.

  PloS one 20070101

• Identification of a stable flavin-thiolate adduct in heterotetrameric sarcosine oxidase.

  Journal of molecular biology 20060929

• Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa.

  Biochemical and biophysical research communications 20060310

• Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro.

  The Biochemical journal 20051215

• Intramolecular electron transfer between tyrosyl radical and cysteine residue inhibits tyrosine nitration and induces thiyl radical formation in model peptides treated with myeloperoxidase, H2O2, and NO2-: EPR SPIN trapping studies.

  The Journal of biological chemistry 20051209

• Thiol-disulphide interchange in tubulin: kinetics and the effect on polymerization.

  The Biochemical journal 20050715

• Antigenotoxic effect of allicin against methyl methanesulphonate induced genotoxic damage.

  Journal of environmental biology 20050701

• Characterization of the norovirus 3C-like protease.

  Virus research 20050601

• 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process.

  Journal of immunology (Baltimore, Md. : 1950) 20040615

• Synthesis of radioiodine labeled dibenzyl disulfide for evaluation of tumor cell uptake.

  Bioorganic & medicinal chemistry 20040301

• Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity.

  Biochemistry 20031118

• Osmotic water permeability and regulatory volume decrease of rat thymocytes.

  General physiology and biophysics 20030601

• Interaction between cysteines introduced into each transmembrane domain of the rat P2X2 receptor.

  British journal of pharmacology 20030101

• Antimicrobial activity of the essential oil and some isolated sulfur-rich compounds from Scorodophloeus zenkeri.

  Planta medica 20021201

• Suppression of UVC-induced cell damage and enhancement of DNA repair by the fermented milk, Kefir.

  Cytotechnology 20021101

• Oxygen-containing sulfur-rich compounds from the bark of the tropical garlic tree Scorodophloeus zenkeri Harms.

  Phytochemistry 20020601

• Formation of methanethiol and dimethyl disulfide in crushed tissues of broccoli florets and their inhibition by freeze-thawing.

  Journal of agricultural and food chemistry 20020313

• Modulation of the reactivity of the essential cysteine residue of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa.

  The Biochemical journal 20020201

• On the nature of conformational openings: native and unfolded-state hydrogen and thiol-disulfide exchange studies of ferric aquomyoglobin.

  Journal of molecular biology 20011116

• Human recombinant interferon-inducible protein-10: intact disulfide bridges are not required for inhibition of hematopoietic progenitors and chemotaxis of T lymphocytes and monocytes.

  Journal of hematotherapy & stem cell research 20010201

• Feeding thiol-containing compounds, derived from vegetables, fails to inhibit N-methylnitrosourea-induced mammary tumorigenesis.

  Cancer detection and prevention 20010101

• Different populations of progesterone receptor-steroid complexes in binding to specific DNA sequences: effects of salts on kinetics and specificity.

  The Journal of steroid biochemistry and molecular biology 19981101

• Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

  The Journal of biological chemistry 19920605

• Localization of the vicinal dithiols involved in steroid binding to the rat glucocorticoid receptor.

  Endocrinology 19901101