301836-43-1 | D4476

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$12.00	$9.00
10mg	98%	in stock	$42.00	$30.00
50mg	98%	in stock	$113.00	$79.00

Description

• Catalog Number: AF31529
• Chemical Name: D4476
• CAS Number: 301836-43-1
• Molecular Formula: C23H18N4O3
• Molecular Weight: 398.4140
• MDL Number: MFCD09037526
• SMILES: NC(=O)c1ccc(cc1)c1nc(c([nH]1)c1ccccn1)c1ccc2c(c1)OCCO2

Computed Properties

• Complexity: 597
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 2.6

Literature

• Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.

  Molecular pain 20140101

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

  European journal of medicinal chemistry 20121001

• Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.

  Neurobiology of disease 20120301

• Protein kinase CK1α regulates erythrocyte survival.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• The interplay of the aryl hydrocarbon receptor and β-catenin alters both AhR-dependent transcription and Wnt/β-catenin signaling in liver progenitors.

  Toxicological sciences : an official journal of the Society of Toxicology 20110801

• Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

  The Journal of biological chemistry 20110128

• 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.

  Journal of medicinal chemistry 20091210

• CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability.

  The Journal of biological chemistry 20091120

• Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening.

  Bioorganic & medicinal chemistry letters 20081015

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.

  EMBO reports 20040101