30220-46-3 | Ingenol

Packsize	Purity	Availability	Price	Discounted Price
1mg	99+%	in stock	$6.00	$4.00
5mg	99+%	in stock	$11.00	$8.00
10mg	99+%	in stock	$15.00	$11.00
25mg	99+%	in stock	$24.00	$17.00
50mg	99+%	in stock	$41.00	$29.00

Description

• Catalog Number: AI46960
• Chemical Name: Ingenol
• CAS Number: 30220-46-3
• Molecular Formula: C20H28O5
• Molecular Weight: 348.4333
• MDL Number: MFCD27980538
• SMILES: OCC1=C[C@H]2[C@H]3[C@H](C3(C)C)C[C@H]([C@]3([C@@]([C@@H]1O)(O)[C@@H](O)C(=C3)C)C2=O)C

Computed Properties

• Complexity: 707
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 1
• XLogP3: 0.2

Literature

• Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR.

  PloS one 20140101

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Bioactivity-guided isolation of antiproliferative diterpenoids from Euphorbia kansui.

  Phytotherapy research : PTR 20120601

• Ingol and ingenol diterpenes from the aerial parts of Euphorbia royleana and their antiangiogenic activities.

  Journal of natural products 20090601

• The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells.

  Neurochemistry international 20081201

• Modern synthetic efforts toward biologically active terpenes.

  Nature chemical biology 20070701

• HIV type 1 inhibition by protein kinase C modulatory compounds.

  AIDS research and human retroviruses 20060901

• A comparison of the roles of protein kinase C in long-term potentiation in rat hippocampal areas CA1 and CA3.

  Cellular and molecular neurobiology 20050601

• Total synthesis of ingenol.

  Journal of the American Chemical Society 20041222

• Selective 1,5-alkylidenecarbene insertion reactions on [3.2.1] oxabicyclic ethers: a new approach toward the AB ring system of ingenol.

  Organic letters 20040819

• Characterization of the interaction of ingenol 3-angelate with protein kinase C.

  Cancer research 20040501

• The effects of protein kinase C activity on synaptic transmission in two areas of rat hippocampus.

  Brain research 20031114

• Total synthesis of ingenol.

  Journal of the American Chemical Society 20030212

• The first total synthesis of (+/-)-ingenol.

  Journal of the American Chemical Society 20020821

• Synthetic studies on the ingenane diterpenes. An improved entry into a trans-intrabridgehead system.

  Organic letters 20020307

• Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells.

  Cellular signalling 20020101

• Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives.

  Archives of virology 19980101